UBXN11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.67002712
2Arp2/3 complex-mediated actin nucleation (GO:0034314)5.67892950
3regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.57991900
4epithelial cilium movement (GO:0003351)5.28515139
5axonemal dynein complex assembly (GO:0070286)5.26285839
6cilium or flagellum-dependent cell motility (GO:0001539)5.01895475
7sperm motility (GO:0030317)4.98647471
8cilium movement (GO:0003341)4.94386615
9fusion of sperm to egg plasma membrane (GO:0007342)4.70113367
10antigen processing and presentation of endogenous antigen (GO:0019883)4.62589648
11acrosome assembly (GO:0001675)4.61513653
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.58060765
13viral transcription (GO:0019083)4.56145362
14acrosome reaction (GO:0007340)4.41534351
15positive regulation of mast cell activation (GO:0033005)4.37969239
16sperm-egg recognition (GO:0035036)4.35950748
17neutrophil activation (GO:0042119)4.35518938
18translational termination (GO:0006415)4.32935760
19cell wall macromolecule metabolic process (GO:0044036)4.31300532
20cell wall macromolecule catabolic process (GO:0016998)4.31300532
21positive regulation of lamellipodium assembly (GO:0010592)4.28610551
22actin nucleation (GO:0045010)4.25609493
23respiratory burst (GO:0045730)4.21592417
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.19374032
25sequestering of actin monomers (GO:0042989)4.19032149
26antigen processing and presentation via MHC class Ib (GO:0002475)4.18433028
27negative regulation of cell killing (GO:0031342)4.07788790
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.07788790
29granulocyte activation (GO:0036230)4.05742694
30GTP biosynthetic process (GO:0006183)4.03908217
31cell-cell recognition (GO:0009988)4.03091913
32multicellular organism reproduction (GO:0032504)4.00300449
33regulation of cilium movement (GO:0003352)3.99931954
34DNA deamination (GO:0045006)3.99756646
35ribosomal small subunit biogenesis (GO:0042274)3.98232631
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.94591925
37binding of sperm to zona pellucida (GO:0007339)3.89644733
38interferon-gamma production (GO:0032609)3.86045789
39motile cilium assembly (GO:0044458)3.84874449
40cellular extravasation (GO:0045123)3.84108615
41response to peptidoglycan (GO:0032494)3.83832819
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83308085
43cotranslational protein targeting to membrane (GO:0006613)3.79090020
44protein targeting to ER (GO:0045047)3.77073071
45regulation of mast cell degranulation (GO:0043304)3.75280602
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72142663
47positive regulation of mast cell activation involved in immune response (GO:0033008)3.64709398
48positive regulation of mast cell degranulation (GO:0043306)3.64709398
49negative regulation of interleukin-12 production (GO:0032695)3.60906550
50myeloid cell activation involved in immune response (GO:0002275)3.59784969
51macrophage activation involved in immune response (GO:0002281)3.59017455
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.58364877
53ribosomal large subunit biogenesis (GO:0042273)3.57589273
54regulation of mast cell activation (GO:0033003)3.57130466
55protein localization to endoplasmic reticulum (GO:0070972)3.56746224
56positive regulation by symbiont of host defense response (GO:0052509)3.56284654
57modulation by symbiont of host defense response (GO:0052031)3.56284654
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.56284654
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.56284654
60positive regulation by organism of defense response of other organism involved in symbiotic interact3.56284654
61modulation by symbiont of host immune response (GO:0052553)3.56284654
62establishment of protein localization to endoplasmic reticulum (GO:0072599)3.55660356
63leukocyte migration involved in inflammatory response (GO:0002523)3.54364691
64mast cell activation (GO:0045576)3.53549583
65regulation of B cell receptor signaling pathway (GO:0050855)3.52826802
66translational elongation (GO:0006414)3.50960023
67spermatid development (GO:0007286)3.49298937
68cellular protein complex disassembly (GO:0043624)3.48033977
69microglial cell activation (GO:0001774)3.47617195
70detection of bacterium (GO:0016045)3.47172511
71detection of other organism (GO:0098543)3.46692354
72regulation of mast cell activation involved in immune response (GO:0033006)3.46205296
73plasma membrane fusion (GO:0045026)3.44937142
74positive regulation of chemokine secretion (GO:0090197)3.43690661
75UTP biosynthetic process (GO:0006228)3.43185678
76viral life cycle (GO:0019058)3.34129063
77lipoxygenase pathway (GO:0019372)3.33896295
78negative regulation of lymphocyte mediated immunity (GO:0002707)3.32383415
79regulation of tolerance induction (GO:0002643)3.31963280
80leukocyte degranulation (GO:0043299)3.31335812
81regulation of germinal center formation (GO:0002634)3.30657790
82regulation of gamma-delta T cell activation (GO:0046643)3.29304326
83ventricular system development (GO:0021591)3.27968060
84leukocyte aggregation (GO:0070486)3.26744171
85reproduction (GO:0000003)3.21053044
86regulation of myeloid leukocyte mediated immunity (GO:0002886)3.20510925
87positive regulation of tolerance induction (GO:0002645)3.16370282
88positive regulation of lamellipodium organization (GO:1902745)3.11071195
89intra-S DNA damage checkpoint (GO:0031573)3.10220738
90regulation of T cell receptor signaling pathway (GO:0050856)3.09624079
91positive thymic T cell selection (GO:0045059)3.08789235
92CTP metabolic process (GO:0046036)3.07134898
93CTP biosynthetic process (GO:0006241)3.07134898
94regulation of leukocyte degranulation (GO:0043300)3.06796266
95B cell mediated immunity (GO:0019724)3.05673501
96regulation of regulatory T cell differentiation (GO:0045589)3.05627324
97nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05511235
98T cell migration (GO:0072678)3.03701475
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.02533520
100mast cell activation involved in immune response (GO:0002279)3.02391475
101mast cell degranulation (GO:0043303)3.02391475
102negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.01891530
103negative regulation of leukocyte mediated immunity (GO:0002704)3.01670809
104regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.01264517
105negative regulation of T cell receptor signaling pathway (GO:0050860)3.01081696
106response to xenobiotic stimulus (GO:0009410)3.00651030
107positive regulation of antigen processing and presentation (GO:0002579)3.00332507
108single fertilization (GO:0007338)2.99896948
109ribosomal small subunit assembly (GO:0000028)2.99877309
110positive regulation of gamma-delta T cell activation (GO:0046645)2.99178244
111protein complex disassembly (GO:0043241)2.98808754
112translational initiation (GO:0006413)2.98155671
113nucleoside diphosphate phosphorylation (GO:0006165)2.94599363
114regulation of antigen processing and presentation (GO:0002577)2.93857084
115immunoglobulin mediated immune response (GO:0016064)2.91269252
116UTP metabolic process (GO:0046051)2.90155906
117macrophage activation (GO:0042116)2.89468618
118cellular response to interleukin-15 (GO:0071350)2.89126067
119superoxide anion generation (GO:0042554)2.88346711
120positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87449677
121positive regulation of B cell mediated immunity (GO:0002714)2.86218129
122positive regulation of immunoglobulin mediated immune response (GO:0002891)2.86218129
123macromolecular complex disassembly (GO:0032984)2.85538485
124thrombin receptor signaling pathway (GO:0070493)2.85528794
125eosinophil chemotaxis (GO:0048245)2.84955097
126interferon-gamma-mediated signaling pathway (GO:0060333)2.84190137
127regulation of T cell mediated cytotoxicity (GO:0001914)2.84020500
128positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.83887593
129positive regulation of B cell differentiation (GO:0045579)2.83285127
130regulation of mononuclear cell migration (GO:0071675)2.83083891
131regulation of gamma-delta T cell differentiation (GO:0045586)2.82405517
132negative T cell selection (GO:0043383)2.81748865
133regulation of platelet aggregation (GO:0090330)2.81665120
134negative thymic T cell selection (GO:0045060)2.81658396
135positive regulation of macrophage differentiation (GO:0045651)2.81322130
136defense response to protozoan (GO:0042832)2.81026785
137G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.79960981
138positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.78757951
139guanosine-containing compound biosynthetic process (GO:1901070)2.78379671
140regulation of platelet activation (GO:0010543)2.75545176
141tolerance induction (GO:0002507)2.75256718
142regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.72869639
143regulation of natural killer cell mediated immunity (GO:0002715)2.72869639
144positive regulation of interleukin-17 production (GO:0032740)2.72668774
145negative regulation of T cell mediated immunity (GO:0002710)2.72616270
146spermatid nucleus differentiation (GO:0007289)2.72509148
147sperm capacitation (GO:0048240)2.72357679
148positive regulation of isotype switching (GO:0045830)2.72107321
149purine deoxyribonucleotide catabolic process (GO:0009155)2.72063478
150adenosine receptor signaling pathway (GO:0001973)2.71516675
151autophagic vacuole fusion (GO:0000046)2.70777235
152detection of external biotic stimulus (GO:0098581)2.70498858
153negative regulation of cytokine production involved in immune response (GO:0002719)2.69936619
154negative regulation of erythrocyte differentiation (GO:0045647)2.69541173
155pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.69056591
156telomere maintenance via semi-conservative replication (GO:0032201)2.67766866
157negative regulation of interleukin-6 production (GO:0032715)2.67607775
158telomere maintenance via recombination (GO:0000722)2.65415772
159response to type I interferon (GO:0034340)2.63769359
160cellular response to type I interferon (GO:0071357)2.63360165
161type I interferon signaling pathway (GO:0060337)2.63360165
162regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62720506
163pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.62630135
164regulation of interleukin-6 biosynthetic process (GO:0045408)2.62404377
165negative regulation of T-helper cell differentiation (GO:0045623)2.62274660
166negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.62274660
167positive regulation of monocyte chemotaxis (GO:0090026)2.61629611
168response to host immune response (GO:0052572)2.61365736
169response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.61365736
170B cell receptor signaling pathway (GO:0050853)2.61216300
171regulation of B cell mediated immunity (GO:0002712)2.61143279
172positive T cell selection (GO:0043368)2.59498268
173response to protozoan (GO:0001562)2.59237080
174myeloid dendritic cell activation (GO:0001773)2.58671087
175negative regulation of necroptotic process (GO:0060546)2.53661988
176deoxyribonucleotide catabolic process (GO:0009264)2.52988095
177regulation of respiratory burst (GO:0060263)2.52740511
178protein targeting to membrane (GO:0006612)2.50582717

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.99015629
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.71017918
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.48105173
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.40506141
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.28970634
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.05995238
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.93185990
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.90438732
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.87207351
10E2F7_22180533_ChIP-Seq_HELA_Human2.75416649
11FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.66853424
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.64007951
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60253819
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58190293
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.52291816
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47603127
17* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45548563
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41350366
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32392665
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26158765
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25335197
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24035124
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20963323
24SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.19735981
25SPI1_23547873_ChIP-Seq_NB4_Human2.19023862
26MYB_26560356_Chip-Seq_TH2_Human2.04325697
27* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.98879606
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89717138
29* MAF_26560356_Chip-Seq_TH1_Human1.88036040
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86447723
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83661920
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82067600
33GATA1_19941826_ChIP-Seq_K562_Human1.82064696
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.79669083
35GATA1_19941827_ChIP-Seq_MEL_Mouse1.76823704
36* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76510193
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73754498
38* MYB_26560356_Chip-Seq_TH1_Human1.73113576
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.70470561
40* RUNX1_22412390_ChIP-Seq_EML_Mouse1.68514741
41VDR_23849224_ChIP-Seq_CD4+_Human1.68006150
42STAT1_20625510_ChIP-Seq_HELA_Human1.64181594
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64045196
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62790308
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60999942
46BCL6_27268052_Chip-Seq_Bcells_Human1.60118058
47VDR_24763502_ChIP-Seq_THP-1_Human1.58408373
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.55971200
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.53408853
50* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.51408478
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50351007
52MAF_26560356_Chip-Seq_TH2_Human1.50032461
53UTX_26944678_Chip-Seq_JUKART_Human1.49411164
54VDR_21846776_ChIP-Seq_THP-1_Human1.48716679
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48573693
56BCOR_27268052_Chip-Seq_Bcells_Human1.48373875
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.47888185
58FOXP3_21729870_ChIP-Seq_TREG_Human1.47173804
59GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45855898
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45793213
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45788833
62RUNX_20019798_ChIP-Seq_JUKART_Human1.45448105
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43910107
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43801747
65GATA3_26560356_Chip-Seq_TH2_Human1.42458228
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40971617
67LXR_22292898_ChIP-Seq_THP-1_Human1.37720341
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.37485244
69EZH2_22144423_ChIP-Seq_EOC_Human1.36887446
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34989648
71PU_27001747_Chip-Seq_BMDM_Mouse1.34446216
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34275106
73* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33337184
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33329487
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32624585
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.31901171
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31193745
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30683227
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30576011
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30543303
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30283110
82GATA2_19941826_ChIP-Seq_K562_Human1.29048046
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28361470
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28195026
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27701490
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27359601
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27119421
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26269675
89* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25478303
90DCP1A_22483619_ChIP-Seq_HELA_Human1.23569632
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21223211
92PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20469497
93P300_27268052_Chip-Seq_Bcells_Human1.20356926
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19771766
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18297102
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17448709
97* GATA2_21666600_ChIP-Seq_HMVEC_Human1.16812398
98* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16806126
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.16240052
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14811693
101TTF2_22483619_ChIP-Seq_HELA_Human1.13421346
102GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13239653
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13134206
104P68_20966046_ChIP-Seq_HELA_Human1.12496809
105IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11565902
106* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10747326
107YY1_22570637_ChIP-Seq_MALME-3M_Human1.10591756
108PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09565682
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09158534
110* TCF7_22412390_ChIP-Seq_EML_Mouse1.08746576
111MYC_22102868_ChIP-Seq_BL_Human1.08448662
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06134700
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05585206
114XRN2_22483619_ChIP-Seq_HELA_Human1.05100570
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05045926
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04196624
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03821660
118NCOR1_26117541_ChIP-Seq_K562_Human1.02457394
119CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00854165
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00609294
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00263561
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98810297
123* E2F1_20622854_ChIP-Seq_HELA_Human0.97974608
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97860446
125CTCF_20526341_ChIP-Seq_ESCs_Human0.97852058
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97527867
127CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96969559
128CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96889643
129RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96854446
130* SPI1_23127762_ChIP-Seq_K562_Human0.95707724
131SCL_19346495_ChIP-Seq_HPC-7_Human0.94786401
132GATA3_27048872_Chip-Seq_THYMUS_Human0.94700006
133MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93615488
134FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93560459
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93386836
136RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92011822
137CTCF_26484167_Chip-Seq_Bcells_Mouse0.89413795
138VDR_24787735_ChIP-Seq_THP-1_Human0.88744000
139MYC_19030024_ChIP-ChIP_MESCs_Mouse0.87397356
140SPI1_20517297_ChIP-Seq_HL60_Human0.86994099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.94639265
2MP0005410_abnormal_fertilization4.47084768
3MP0009379_abnormal_foot_pigmentation3.79649279
4MP0005671_abnormal_response_to3.18154601
5MP0001835_abnormal_antigen_presentation3.12060977
6MP0002138_abnormal_hepatobiliary_system2.89397397
7MP0000685_abnormal_immune_system2.79380664
8MP0003763_abnormal_thymus_physiology2.72830145
9MP0002148_abnormal_hypersensitivity_rea2.56157503
10MP0001800_abnormal_humoral_immune2.39380965
11MP0009785_altered_susceptibility_to2.39316240
12MP0005000_abnormal_immune_tolerance2.36655078
13MP0003436_decreased_susceptibility_to2.36577209
14MP0005174_abnormal_tail_pigmentation2.29799531
15MP0005025_abnormal_response_to2.28492783
16MP0002452_abnormal_antigen_presenting2.27634223
17MP0005387_immune_system_phenotype2.22090249
18MP0001790_abnormal_immune_system2.22090249
19MP0002420_abnormal_adaptive_immunity2.20259953
20MP0000465_gastrointestinal_hemorrhage2.20121588
21MP0002723_abnormal_immune_serum2.17321228
22MP0001819_abnormal_immune_cell2.16995075
23MP0008004_abnormal_stomach_pH2.11436368
24MP0002419_abnormal_innate_immunity2.04433823
25MP0003806_abnormal_nucleotide_metabolis1.97573605
26MP0003011_delayed_dark_adaptation1.97225027
27MP0002405_respiratory_system_inflammati1.90322817
28MP0006082_CNS_inflammation1.87230399
29MP0000015_abnormal_ear_pigmentation1.86748260
30MP0003300_gastrointestinal_ulcer1.82622549
31MP0002398_abnormal_bone_marrow1.80532697
32MP0003172_abnormal_lysosome_physiology1.79195545
33MP0003866_abnormal_defecation1.75379394
34MP0003724_increased_susceptibility_to1.71468960
35MP0003698_abnormal_male_reproductive1.71185156
36MP0009764_decreased_sensitivity_to1.71073381
37MP0003136_yellow_coat_color1.70814785
38MP0004510_myositis1.69965558
39MP0009333_abnormal_splenocyte_physiolog1.68591921
40MP0000716_abnormal_immune_system1.68519621
41MP0004947_skin_inflammation1.63759461
42MP0003075_altered_response_to1.59807241
43MP0001986_abnormal_taste_sensitivity1.55881102
44MP0003880_abnormal_central_pattern1.53197022
45MP0001851_eye_inflammation1.50548380
46MP0001929_abnormal_gametogenesis1.50061094
47MP0008007_abnormal_cellular_replicative1.49808866
48MP0005075_abnormal_melanosome_morpholog1.48331658
49MP0004381_abnormal_hair_follicle1.47922101
50MP0010155_abnormal_intestine_physiology1.45635987
51MP0003941_abnormal_skin_development1.44972031
52MP0000858_altered_metastatic_potential1.42003714
53MP0002166_altered_tumor_susceptibility1.41237257
54MP0008877_abnormal_DNA_methylation1.41100596
55MP0002429_abnormal_blood_cell1.37767425
56MP0008875_abnormal_xenobiotic_pharmacok1.37605786
57MP0002095_abnormal_skin_pigmentation1.36446541
58MP0002396_abnormal_hematopoietic_system1.35481705
59MP0002653_abnormal_ependyma_morphology1.35406093
60MP0000689_abnormal_spleen_morphology1.34522600
61MP0009278_abnormal_bone_marrow1.34157246
62MP0001663_abnormal_digestive_system1.33748452
63MP0000490_abnormal_crypts_of1.31086919
64MP0002722_abnormal_immune_system1.30812769
65MP0000703_abnormal_thymus_morphology1.29608942
66MP0003191_abnormal_cellular_cholesterol1.19251709
67MP0005083_abnormal_biliary_tract1.18748627
68MP0001188_hyperpigmentation1.18059725
69MP0001873_stomach_inflammation1.18017941
70MP0001845_abnormal_inflammatory_respons1.17697146
71MP0005464_abnormal_platelet_physiology1.17304347
72MP0009763_increased_sensitivity_to1.15334455
73MP0008260_abnormal_autophagy1.13557670
74MP0003448_altered_tumor_morphology1.12073666
75MP0002006_tumorigenesis1.09698301
76MP0005397_hematopoietic_system_phenotyp1.08052749
77MP0001545_abnormal_hematopoietic_system1.08052749
78MP0003828_pulmonary_edema1.05190203
79MP0000343_altered_response_to1.04725340
80MP0002210_abnormal_sex_determination1.04096871
81MP0002638_abnormal_pupillary_reflex0.98884386
82MP0005310_abnormal_salivary_gland0.98442491
83MP0004883_abnormal_blood_vessel0.96671977
84MP0008058_abnormal_DNA_repair0.96429345
85MP0005167_abnormal_blood-brain_barrier0.95850094
86MP0003656_abnormal_erythrocyte_physiolo0.95253478
87MP0005409_darkened_coat_color0.93380535
88MP0008057_abnormal_DNA_replication0.89520117
89MP0000249_abnormal_blood_vessel0.87876824
90MP0005390_skeleton_phenotype0.87419127
91MP0009765_abnormal_xenobiotic_induced0.87176156
92MP0010094_abnormal_chromosome_stability0.86714930
93MP0005381_digestive/alimentary_phenotyp0.84947986
94MP0005165_increased_susceptibility_to0.84703393
95MP0005084_abnormal_gallbladder_morpholo0.84644359
96MP0008469_abnormal_protein_level0.84045122
97MP0005551_abnormal_eye_electrophysiolog0.83646681
98MP0003879_abnormal_hair_cell0.83217606
99MP0001533_abnormal_skeleton_physiology0.82451216
100MP0005164_abnormal_response_to0.82292445
101MP0003638_abnormal_response/metabolism_0.81774229
102MP0001145_abnormal_male_reproductive0.81572454
103MP0002161_abnormal_fertility/fecundity0.81024789
104MP0000372_irregular_coat_pigmentation0.80362486
105MP0004808_abnormal_hematopoietic_stem0.77495161
106MP0006292_abnormal_olfactory_placode0.76328747
107MP0008932_abnormal_embryonic_tissue0.74427812
108MP0001765_abnormal_ion_homeostasis0.73366078
109MP0005058_abnormal_lysosome_morphology0.73265549
110MP0002132_abnormal_respiratory_system0.72756524
111MP0009840_abnormal_foam_cell0.72652325
112MP0001542_abnormal_bone_strength0.72013159
113MP0003183_abnormal_peptide_metabolism0.70891227
114MP0005365_abnormal_bile_salt0.70652216
115MP0002933_joint_inflammation0.69930104
116MP0000604_amyloidosis0.69340389
117MP0003795_abnormal_bone_structure0.67853675
118MP0005166_decreased_susceptibility_to0.67687675
119MP0002009_preneoplasia0.67631581
120MP0003878_abnormal_ear_physiology0.66955415
121MP0005377_hearing/vestibular/ear_phenot0.66955415
122MP0002277_abnormal_respiratory_mucosa0.65484928
123MP0001324_abnormal_eye_pigmentation0.64896648
124MP0001853_heart_inflammation0.64888022
125MP0002019_abnormal_tumor_incidence0.64502305
126MP0000681_abnormal_thyroid_gland0.63586651
127MP0006036_abnormal_mitochondrial_physio0.63575275
128MP0000613_abnormal_salivary_gland0.63127082
129MP0008874_decreased_physiological_sensi0.63063053
130MP0005253_abnormal_eye_physiology0.62603084
131MP0000230_abnormal_systemic_arterial0.62457755
132MP0000653_abnormal_sex_gland0.61406178
133MP0001968_abnormal_touch/_nociception0.60982523
134MP0002998_abnormal_bone_remodeling0.60309237
135MP0009642_abnormal_blood_homeostasis0.59534211
136MP0006054_spinal_hemorrhage0.58982414
137MP0002136_abnormal_kidney_physiology0.56265999

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.60482765
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.72004117
3Absent/shortened dynein arms (HP:0200106)5.72004117
4Eczematoid dermatitis (HP:0000976)5.44429902
5Abnormal respiratory motile cilium physiology (HP:0012261)5.26177482
6Stomatitis (HP:0010280)5.20915685
7Petechiae (HP:0000967)4.75646212
8Abnormal ciliary motility (HP:0012262)4.75350010
9Purpura (HP:0000979)4.74707692
10Abnormal respiratory motile cilium morphology (HP:0005938)4.72321403
11Abnormal respiratory epithelium morphology (HP:0012253)4.72321403
12Recurrent abscess formation (HP:0002722)4.62487736
13Obstructive lung disease (HP:0006536)4.59052044
14Chronic obstructive pulmonary disease (HP:0006510)4.59052044
15Recurrent bacterial skin infections (HP:0005406)4.39511313
16Nasal polyposis (HP:0100582)4.16076573
17Rhinitis (HP:0012384)4.10119835
18Recurrent gram-negative bacterial infections (HP:0005420)4.07254819
19Epistaxis (HP:0000421)3.86000028
20Menorrhagia (HP:0000132)3.62516469
21Recurrent sinusitis (HP:0011108)3.55454900
22Abnormality of the nasal mucosa (HP:0000433)3.55155732
23Recurrent bronchitis (HP:0002837)3.46615478
24Bronchiectasis (HP:0002110)3.40773076
25Abnormal platelet volume (HP:0011876)3.32893337
26Bronchitis (HP:0012387)3.26454397
27Optic neuritis (HP:0100653)3.24287730
28Retrobulbar optic neuritis (HP:0100654)3.24287730
29Orchitis (HP:0100796)3.21699913
30Recurrent fungal infections (HP:0002841)3.19444183
31Vacuolated lymphocytes (HP:0001922)3.17594236
32Recurrent skin infections (HP:0001581)3.14299478
33Mutism (HP:0002300)3.12779196
34Gingival bleeding (HP:0000225)3.10722803
35Increased mean platelet volume (HP:0011877)3.03994320
36Disinhibition (HP:0000734)3.00419085
37Chronic bronchitis (HP:0004469)2.96212774
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.95684107
39Mediastinal lymphadenopathy (HP:0100721)2.95261301
40Recurrent cutaneous fungal infections (HP:0011370)2.93458382
41Chronic mucocutaneous candidiasis (HP:0002728)2.93458382
42Increased cerebral lipofuscin (HP:0011813)2.93017100
43Elevated erythrocyte sedimentation rate (HP:0003565)2.86222101
44Spontaneous hematomas (HP:0007420)2.85797668
45Meningitis (HP:0001287)2.85511253
46Abnormality of macrophages (HP:0004311)2.85380254
47Reticulocytopenia (HP:0001896)2.74970143
48Abnormality of liposaccharide metabolism (HP:0010968)2.74782206
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.74782206
50Abnormality of glycolipid metabolism (HP:0010969)2.74782206
51Dysostosis multiplex (HP:0000943)2.71535115
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.59468264
53Gingivitis (HP:0000230)2.59168946
54Increased serum ferritin (HP:0003281)2.56858904
55Hepatosplenomegaly (HP:0001433)2.56838363
56Panhypogammaglobulinemia (HP:0003139)2.56713109
57Infertility (HP:0000789)2.53253100
58Male infertility (HP:0003251)2.47968861
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43495632
60Exertional dyspnea (HP:0002875)2.43121359
61Vasculitis (HP:0002633)2.42528649
62Hyperlipoproteinemia (HP:0010980)2.42265156
63Myositis (HP:0100614)2.42051225
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.41530267
65Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37407536
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37407536
67T lymphocytopenia (HP:0005403)2.36385475
68Abnormal pupillary function (HP:0007686)2.36331675
69Abnormality of iron homeostasis (HP:0011031)2.35630952
70Medial flaring of the eyebrow (HP:0010747)2.34069619
71Episodic fever (HP:0001954)2.33270960
72Abnormal rod and cone electroretinograms (HP:0008323)2.33123922
73Agammaglobulinemia (HP:0004432)2.32560312
74Congenital stationary night blindness (HP:0007642)2.32173628
75Nephronophthisis (HP:0000090)2.31843547
76Abnormal platelet function (HP:0011869)2.30256264
77Impaired platelet aggregation (HP:0003540)2.30256264
78Pulmonary infiltrates (HP:0002113)2.29755635
79Pustule (HP:0200039)2.28058047
80Severe visual impairment (HP:0001141)2.26935239
81Abnormality of T cells (HP:0002843)2.26065195
82Amyloidosis (HP:0011034)2.26048799
83Prolonged bleeding time (HP:0003010)2.24914719
84Abnormality of T cell number (HP:0011839)2.24883931
85Severe combined immunodeficiency (HP:0004430)2.22419707
86Personality changes (HP:0000751)2.22069834
87Macrocytic anemia (HP:0001972)2.21719952
88Recurrent pneumonia (HP:0006532)2.20940646
89Gastrointestinal infarctions (HP:0005244)2.19653609
90Chronic sinusitis (HP:0011109)2.19317399
91IgM deficiency (HP:0002850)2.19016550
92Chronic otitis media (HP:0000389)2.18727238
93Cleft eyelid (HP:0000625)2.17992640
94Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.17183690
95Recurrent otitis media (HP:0000403)2.16855482
96Joint swelling (HP:0001386)2.15528383
97Recurrent viral infections (HP:0004429)2.14835624
98Abnormal hemoglobin (HP:0011902)2.14516714
99Keratoconjunctivitis sicca (HP:0001097)2.14014849
100Keratoconjunctivitis (HP:0001096)2.11800612
101Hemoptysis (HP:0002105)2.11721287
102Hypergammaglobulinemia (HP:0010702)2.10337486
103Pallor (HP:0000980)2.09538730
104Loss of speech (HP:0002371)2.09378203
105Attenuation of retinal blood vessels (HP:0007843)2.09027426
106Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08980875
107Autoimmune thrombocytopenia (HP:0001973)2.08033533
108Leukocytosis (HP:0001974)2.07069125
109Abnormality of the prostate (HP:0008775)2.06670444
110Increased IgE level (HP:0003212)2.05594570
111Abnormal number of erythroid precursors (HP:0012131)2.04467885
112Abnormal spermatogenesis (HP:0008669)2.03931572
113Abnormality of transition element cation homeostasis (HP:0011030)2.03377088
114Cellulitis (HP:0100658)2.03332103
115Arterial thrombosis (HP:0004420)2.02986230
116Abnormality of T cell physiology (HP:0011840)2.00557656
117Diminished motivation (HP:0000745)1.95724372
118Anorexia (HP:0002039)1.93682170
119Basal ganglia calcification (HP:0002135)1.93030098
120Systemic lupus erythematosus (HP:0002725)1.92462050
121Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90729084
122Urticaria (HP:0001025)1.90401850
123Chest pain (HP:0100749)1.90222840
124Granulocytopenia (HP:0001913)1.90062397
125Hepatocellular necrosis (HP:0001404)1.89778952
126Recurrent lower respiratory tract infections (HP:0002783)1.89241674
127Prostate neoplasm (HP:0100787)1.87667042
128IgG deficiency (HP:0004315)1.87652790
129Pulmonary embolism (HP:0002204)1.86848314
130Abnormality of cells of the erythroid lineage (HP:0012130)1.86113873
131True hermaphroditism (HP:0010459)1.85495235
132Inflammation of the large intestine (HP:0002037)1.85452569
133Gangrene (HP:0100758)1.85404491
134Increased hepatocellular lipid droplets (HP:0006565)1.84570967
135Encephalitis (HP:0002383)1.84167412
136Abnormality of lateral ventricle (HP:0030047)1.83731685
137Combined immunodeficiency (HP:0005387)1.80233887
138Thrombocytosis (HP:0001894)1.79981335
139Inappropriate behavior (HP:0000719)1.77670942
140Abnormality of midbrain morphology (HP:0002418)1.74431766
141Molar tooth sign on MRI (HP:0002419)1.74431766
142Increased IgM level (HP:0003496)1.74396436
143Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73494089
144Abnormality of eosinophils (HP:0001879)1.72353815
145Pulmonary fibrosis (HP:0002206)1.71420469
146Thyroiditis (HP:0100646)1.69703174
147Abnormality of cells of the lymphoid lineage (HP:0012140)1.69453832
148Decreased central vision (HP:0007663)1.69006923
149Pancreatic fibrosis (HP:0100732)1.68498550
150Gastrointestinal inflammation (HP:0004386)1.68484392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.62492594
2PIM24.16689197
3TESK23.93099553
4TESK13.37503582
5NME23.28728131
6EIF2AK13.21073012
7MAP4K13.03464088
8BLK3.01091537
9IRAK42.62781788
10RIPK42.20546538
11MAP2K32.09461672
12DYRK1B2.04988303
13TNK22.00935038
14TXK1.99503637
15NEK91.97521253
16KIT1.80117520
17MAP3K131.76068583
18TEC1.72132964
19MST41.70879145
20MAP3K31.69448858
21BMPR21.68775874
22ZAP701.58437618
23MAP3K121.58276874
24STK161.54943570
25CASK1.51690878
26IRAK11.48142373
27ERN11.32045680
28CSF1R1.31063570
29IRAK31.31002102
30MATK1.28776623
31PBK1.28423183
32CLK11.28191571
33DAPK31.25816450
34GRK71.25706444
35CDK191.24753681
36IRAK21.24561624
37FES1.23417667
38BMX1.20614150
39MAPKAPK31.18050160
40IKBKE1.17997204
41EIF2AK31.17410587
42BTK1.15860022
43TAOK11.12637591
44NLK1.10116765
45STK381.09055574
46PDK41.08078874
47PDK31.08078874
48SYK1.07384342
49EPHB11.06496638
50MKNK21.05830183
51TNIK1.05211729
52VRK11.04053849
53LCK1.03768747
54ARAF1.01243807
55PIM11.00046551
56MYLK0.99418927
57CSK0.97232740
58TAOK20.96826631
59TBK10.96314629
60YES10.94362129
61MAP3K110.93405045
62ITK0.93236251
63DYRK30.92848141
64GRK50.89781263
65JAK10.87224514
66TGFBR20.86163311
67PTK2B0.85753727
68LYN0.84711130
69STK390.84550043
70MAP3K140.82960901
71LIMK10.79097935
72TAOK30.76481635
73ABL20.75803774
74PRKD20.75133385
75WEE10.74678574
76IKBKB0.72710864
77MOS0.71517601
78ILK0.70057382
79MAP3K10.66059478
80ADRBK20.63250971
81TYK20.63047775
82SRPK10.62853715
83MAPK120.61656551
84WNK40.61653631
85KDR0.61483703
86PDPK10.60748099
87PIK3CG0.58513563
88PAK10.57214523
89MAPK150.56808836
90PDK20.56190856
91GRK60.56082571
92CDC42BPA0.55964229
93HCK0.55686344
94EPHA30.54240224
95FYN0.53495663
96PRPF4B0.51066022
97SCYL20.50484262
98MAP3K50.49595164
99FGR0.49509197
100CDK60.49350814
101PRKCQ0.48600802
102MAP2K70.47496547
103BUB10.47371374
104MAP2K20.46954757
105JAK30.46299011
106STK100.40997530
107LRRK20.40942730
108ADRBK10.40280713
109TSSK60.38848365
110JAK20.38827318
111MKNK10.38760870
112MAPK70.38554478
113DAPK10.37408211
114CAMKK10.36652427
115MAPKAPK20.34480620
116SIK20.34130977
117PRKD10.34094863
118ABL10.33987433
119MAPK40.33869468
120CHUK0.33251267
121PRKCD0.30665829
122CAMKK20.30425586
123STK240.30033994
124PNCK0.29919238
125MARK20.29804248
126CCNB10.27913900
127HIPK20.27583190
128MAPKAPK50.26739425
129CSNK2A10.24772146
130ACVR1B0.23999517
131ERBB20.23908727
132MAP3K70.23175336
133PDK10.22134347
134DAPK20.21574286
135STK110.21241752
136SIK30.19555680
137CDK140.19209980
138MAP2K60.18774869
139CSNK2A20.18261744
140MARK30.18159264
141CDK90.17644916

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.84212580
2Primary immunodeficiency_Homo sapiens_hsa053403.61842217
3DNA replication_Homo sapiens_hsa030302.66321850
4Staphylococcus aureus infection_Homo sapiens_hsa051502.63771498
5Phototransduction_Homo sapiens_hsa047442.23846597
6Type I diabetes mellitus_Homo sapiens_hsa049402.23818659
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.11656053
8Antigen processing and presentation_Homo sapiens_hsa046122.11386477
9Protein export_Homo sapiens_hsa030602.10727426
10Homologous recombination_Homo sapiens_hsa034402.09492289
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03507539
12Mismatch repair_Homo sapiens_hsa034301.71623968
13Other glycan degradation_Homo sapiens_hsa005111.70300541
14RNA polymerase_Homo sapiens_hsa030201.68263018
15Leishmaniasis_Homo sapiens_hsa051401.67309028
16Shigellosis_Homo sapiens_hsa051311.64824650
17Hematopoietic cell lineage_Homo sapiens_hsa046401.61296411
18T cell receptor signaling pathway_Homo sapiens_hsa046601.58509145
19Spliceosome_Homo sapiens_hsa030401.56632674
20Proteasome_Homo sapiens_hsa030501.56527090
21Fanconi anemia pathway_Homo sapiens_hsa034601.55457707
22Base excision repair_Homo sapiens_hsa034101.55416428
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.49928203
24B cell receptor signaling pathway_Homo sapiens_hsa046621.48576888
25Measles_Homo sapiens_hsa051621.48480254
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47379514
27Basal transcription factors_Homo sapiens_hsa030221.46862250
28Osteoclast differentiation_Homo sapiens_hsa043801.42003153
29Salmonella infection_Homo sapiens_hsa051321.41209098
30Nucleotide excision repair_Homo sapiens_hsa034201.37610997
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.32337790
32Pyrimidine metabolism_Homo sapiens_hsa002401.29919750
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28679711
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25906494
35Huntingtons disease_Homo sapiens_hsa050161.23570802
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.22244091
37Oxidative phosphorylation_Homo sapiens_hsa001901.18086993
38Arachidonic acid metabolism_Homo sapiens_hsa005901.16881699
39Parkinsons disease_Homo sapiens_hsa050121.14180950
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.13406134
41Phagosome_Homo sapiens_hsa041451.11920851
42Herpes simplex infection_Homo sapiens_hsa051681.11500124
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08615646
44TNF signaling pathway_Homo sapiens_hsa046681.06763062
45Pertussis_Homo sapiens_hsa051331.05088548
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04322559
47Epstein-Barr virus infection_Homo sapiens_hsa051691.03111865
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01916594
49Graft-versus-host disease_Homo sapiens_hsa053321.01742295
50Allograft rejection_Homo sapiens_hsa053300.97584339
51Sulfur relay system_Homo sapiens_hsa041220.95306522
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93613831
53Chemokine signaling pathway_Homo sapiens_hsa040620.92330357
54Viral myocarditis_Homo sapiens_hsa054160.90171215
55Tuberculosis_Homo sapiens_hsa051520.87495497
56Pentose phosphate pathway_Homo sapiens_hsa000300.87335182
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87189912
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86582259
59Purine metabolism_Homo sapiens_hsa002300.86143689
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85427397
61Sphingolipid metabolism_Homo sapiens_hsa006000.85133646
62African trypanosomiasis_Homo sapiens_hsa051430.85106713
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84462113
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83323864
65Malaria_Homo sapiens_hsa051440.82292266
66Acute myeloid leukemia_Homo sapiens_hsa052210.81304674
67Regulation of autophagy_Homo sapiens_hsa041400.81152877
68Endocytosis_Homo sapiens_hsa041440.78977481
69Alzheimers disease_Homo sapiens_hsa050100.78907565
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78037072
71Legionellosis_Homo sapiens_hsa051340.77770427
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.76173116
73Toxoplasmosis_Homo sapiens_hsa051450.74223612
74Chemical carcinogenesis_Homo sapiens_hsa052040.72662947
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72078529
76Hepatitis C_Homo sapiens_hsa051600.68423234
77Influenza A_Homo sapiens_hsa051640.66585621
78Linoleic acid metabolism_Homo sapiens_hsa005910.64238151
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63904358
80Hepatitis B_Homo sapiens_hsa051610.62417258
81Non-homologous end-joining_Homo sapiens_hsa034500.62352835
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62244900
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62083954
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60884131
85Asthma_Homo sapiens_hsa053100.60585201
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60229225
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60120413
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58336299
89Platelet activation_Homo sapiens_hsa046110.56334132
90Glutathione metabolism_Homo sapiens_hsa004800.54269562
91Rheumatoid arthritis_Homo sapiens_hsa053230.54239384
92RNA transport_Homo sapiens_hsa030130.53116443
93p53 signaling pathway_Homo sapiens_hsa041150.52985856
94Ether lipid metabolism_Homo sapiens_hsa005650.52052933
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51510148
96Cell cycle_Homo sapiens_hsa041100.51405703
97RNA degradation_Homo sapiens_hsa030180.50716145
98Renin secretion_Homo sapiens_hsa049240.50265999
99Autoimmune thyroid disease_Homo sapiens_hsa053200.47469956
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47380802
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46901910
102Thyroid cancer_Homo sapiens_hsa052160.46732282
103Apoptosis_Homo sapiens_hsa042100.46597994
104Collecting duct acid secretion_Homo sapiens_hsa049660.46290217
105Lysosome_Homo sapiens_hsa041420.45131728
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.43715138
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.42970624
108mRNA surveillance pathway_Homo sapiens_hsa030150.42644124
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.42164006
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41319500
111Systemic lupus erythematosus_Homo sapiens_hsa053220.41203736
112Synaptic vesicle cycle_Homo sapiens_hsa047210.40816266
113VEGF signaling pathway_Homo sapiens_hsa043700.39956962
114HTLV-I infection_Homo sapiens_hsa051660.39895160
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38599356
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35782704
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35544039
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34950827
119Olfactory transduction_Homo sapiens_hsa047400.33878037
120Oocyte meiosis_Homo sapiens_hsa041140.33836291
121Amoebiasis_Homo sapiens_hsa051460.33122953
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32535884
123Viral carcinogenesis_Homo sapiens_hsa052030.32383367
124Glycerolipid metabolism_Homo sapiens_hsa005610.31956191
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.30142150
126Prolactin signaling pathway_Homo sapiens_hsa049170.30106815
127Cardiac muscle contraction_Homo sapiens_hsa042600.30048154
128Notch signaling pathway_Homo sapiens_hsa043300.29861740
129Histidine metabolism_Homo sapiens_hsa003400.28654151
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28614986
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.26522368
132Sulfur metabolism_Homo sapiens_hsa009200.26038667
133ABC transporters_Homo sapiens_hsa020100.25533023
134Complement and coagulation cascades_Homo sapiens_hsa046100.25441131
135Choline metabolism in cancer_Homo sapiens_hsa052310.25283379
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.24682078
137Serotonergic synapse_Homo sapiens_hsa047260.22929228

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