UBXN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.60921183
2COPI coating of Golgi vesicle (GO:0048205)5.60921183
3COPII vesicle coating (GO:0048208)5.22986482
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.08315302
5exocrine pancreas development (GO:0031017)5.00678455
6high-density lipoprotein particle remodeling (GO:0034375)4.85118212
7signal peptide processing (GO:0006465)4.82154006
8regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.70901061
9endocrine pancreas development (GO:0031018)4.58738950
10ER overload response (GO:0006983)4.48781154
11reverse cholesterol transport (GO:0043691)4.43321175
12L-phenylalanine catabolic process (GO:0006559)4.42965927
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.42965927
14plasma lipoprotein particle assembly (GO:0034377)4.36576156
15positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.32979535
16ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.29481550
17regulation of cholesterol esterification (GO:0010872)4.29309166
18sequestering of metal ion (GO:0051238)4.22664394
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.21832206
20retrograde transport, vesicle recycling within Golgi (GO:0000301)4.21740890
21negative regulation of protein activation cascade (GO:2000258)4.15161407
22regulation of type B pancreatic cell apoptotic process (GO:2000674)4.03701396
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.95389066
24L-phenylalanine metabolic process (GO:0006558)3.95389066
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.88580677
26very-low-density lipoprotein particle assembly (GO:0034379)3.87426628
27activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.84043588
28Sertoli cell development (GO:0060009)3.83060124
29phospholipid efflux (GO:0033700)3.79370817
30transcytosis (GO:0045056)3.77220868
31cholesterol efflux (GO:0033344)3.69991621
32intestinal cholesterol absorption (GO:0030299)3.69332719
33plasma lipoprotein particle remodeling (GO:0034369)3.68690498
34protein-lipid complex remodeling (GO:0034368)3.68690498
35macromolecular complex remodeling (GO:0034367)3.68690498
36aromatic amino acid family catabolic process (GO:0009074)3.67838863
37endoplasmic reticulum unfolded protein response (GO:0030968)3.67108570
38inner ear receptor cell differentiation (GO:0060113)3.66708578
39genitalia morphogenesis (GO:0035112)3.66068660
40peptide hormone processing (GO:0016486)3.65419130
41glandular epithelial cell differentiation (GO:0002067)3.61686387
42cellular response to unfolded protein (GO:0034620)3.61342866
43positive regulation of nuclease activity (GO:0032075)3.59467268
44peptidyl-glutamic acid carboxylation (GO:0017187)3.54094604
45protein carboxylation (GO:0018214)3.54094604
46auditory receptor cell differentiation (GO:0042491)3.48925083
47cysteine metabolic process (GO:0006534)3.48385789
48ER-nucleus signaling pathway (GO:0006984)3.42806670
49pyrimidine-containing compound transmembrane transport (GO:0072531)3.41818639
50centriole replication (GO:0007099)3.40212264
51negative regulation of complement activation (GO:0045916)3.38087524
52cellular response to topologically incorrect protein (GO:0035967)3.37835918
53epithelial cilium movement (GO:0003351)3.37450864
54intra-Golgi vesicle-mediated transport (GO:0006891)3.32747208
55protein retention in ER lumen (GO:0006621)3.30854501
56protein maturation by protein folding (GO:0022417)3.28269070
57phospholipid homeostasis (GO:0055091)3.26900734
58intraciliary transport (GO:0042073)3.26787238
59negative regulation of lipase activity (GO:0060192)3.24847099
60response to endoplasmic reticulum stress (GO:0034976)3.23127355
61regulation of nuclease activity (GO:0032069)3.21824421
624-hydroxyproline metabolic process (GO:0019471)3.19896600
63cilium movement (GO:0003341)3.15892809
64plasma lipoprotein particle organization (GO:0071827)3.12620327
65cholesterol biosynthetic process (GO:0006695)3.10914941
66tryptophan metabolic process (GO:0006568)3.09324029
67axoneme assembly (GO:0035082)3.08646265
68retinal metabolic process (GO:0042574)3.07252325
69embryonic retina morphogenesis in camera-type eye (GO:0060059)3.07164839
70triglyceride homeostasis (GO:0070328)3.04810971
71acylglycerol homeostasis (GO:0055090)3.04810971
72uronic acid metabolic process (GO:0006063)3.04695803
73glucuronate metabolic process (GO:0019585)3.04695803
74indole-containing compound catabolic process (GO:0042436)3.03167158
75indolalkylamine catabolic process (GO:0046218)3.03167158
76tryptophan catabolic process (GO:0006569)3.03167158
77cellular ketone body metabolic process (GO:0046950)3.02287655
78coenzyme catabolic process (GO:0009109)3.00618726
79isoprenoid biosynthetic process (GO:0008299)2.99130254
80regulation of fibrinolysis (GO:0051917)2.98695923
81phenylpropanoid metabolic process (GO:0009698)2.96251165
82sterol biosynthetic process (GO:0016126)2.96249470
83histone H3-K4 trimethylation (GO:0080182)2.94320951
84positive regulation of histone H3-K4 methylation (GO:0051571)2.93196651
85regulation of meiosis I (GO:0060631)2.93122533
86type B pancreatic cell development (GO:0003323)2.90311177
87bile acid metabolic process (GO:0008206)2.90276708
88neural tube formation (GO:0001841)2.89451323
89nucleotide transmembrane transport (GO:1901679)2.89120892
90valine metabolic process (GO:0006573)2.88279613
91rRNA catabolic process (GO:0016075)2.87230599
92fibrinolysis (GO:0042730)2.86685274
93protein localization to Golgi apparatus (GO:0034067)2.84839689
94negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.84672357
95low-density lipoprotein particle remodeling (GO:0034374)2.83647008
96* response to unfolded protein (GO:0006986)2.83461939
97negative regulation of digestive system process (GO:0060457)2.83371732
98retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.82785250
99protein-lipid complex subunit organization (GO:0071825)2.82641556
100aromatic amino acid family metabolic process (GO:0009072)2.82173599
101muscle organ morphogenesis (GO:0048644)2.81620803
102tyrosine metabolic process (GO:0006570)2.77466614
103indolalkylamine metabolic process (GO:0006586)2.74899470
104regulation of heterotypic cell-cell adhesion (GO:0034114)2.74688698
105triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.74316191
106protein targeting to Golgi (GO:0000042)2.74309614
107ER to Golgi vesicle-mediated transport (GO:0006888)2.73947271
108regulation of lipoprotein metabolic process (GO:0050746)2.73678975
109vesicle coating (GO:0006901)2.72483620
110* response to topologically incorrect protein (GO:0035966)2.71983589
111cholesterol transport (GO:0030301)2.71946951
112sterol transport (GO:0015918)2.71946951
113negative regulation of humoral immune response (GO:0002921)2.71604834
114diterpenoid biosynthetic process (GO:0016102)2.71378129
115photoreceptor cell differentiation (GO:0046530)2.71255315
116eye photoreceptor cell differentiation (GO:0001754)2.71255315
117opsonization (GO:0008228)2.70617549
118cellular response to ATP (GO:0071318)2.69816378
119regulation of cilium movement (GO:0003352)2.67951775
120detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.64457093
121negative regulation of cholesterol transport (GO:0032375)2.64357265
122negative regulation of sterol transport (GO:0032372)2.64357265
123amine catabolic process (GO:0009310)2.63557435
124cellular biogenic amine catabolic process (GO:0042402)2.63557435
125regulation of protein activation cascade (GO:2000257)2.63150092
126ketone body metabolic process (GO:1902224)2.62810392
127artery smooth muscle contraction (GO:0014824)2.62514849
128Leydig cell differentiation (GO:0033327)2.62181119
129regulation of cytokine secretion involved in immune response (GO:0002739)2.62020713
130positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.61234213
131retinol metabolic process (GO:0042572)2.60203525
132complement activation, alternative pathway (GO:0006957)2.60150116
133mitotic sister chromatid cohesion (GO:0007064)2.60026264
134regulation of plasminogen activation (GO:0010755)2.59845993
135cholesterol homeostasis (GO:0042632)2.59752110
136sulfur amino acid catabolic process (GO:0000098)2.58790442
137protein N-linked glycosylation via asparagine (GO:0018279)2.58614519
138regulation of male gonad development (GO:2000018)2.58024920
139drug transmembrane transport (GO:0006855)2.57860871
140sterol homeostasis (GO:0055092)2.57653693
141bile acid and bile salt transport (GO:0015721)2.57240459
142positive regulation of hormone biosynthetic process (GO:0046886)2.56901616
143UDP-N-acetylglucosamine metabolic process (GO:0006047)2.56552822
144cellular response to vitamin D (GO:0071305)2.56393128
145axonemal dynein complex assembly (GO:0070286)2.56383608
146positive regulation of glycoprotein biosynthetic process (GO:0010560)2.56359218
147macroautophagy (GO:0016236)2.55852309
148Golgi to endosome transport (GO:0006895)2.54873124
149peptidyl-asparagine modification (GO:0018196)2.54330034
150regulation of energy homeostasis (GO:2000505)2.54269662
151bile acid biosynthetic process (GO:0006699)2.53626467
152regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53360193
153intestinal absorption (GO:0050892)2.51129452
154phosphatidylcholine biosynthetic process (GO:0006656)2.50876186
155branched-chain amino acid catabolic process (GO:0009083)2.50354086
156regulation of acrosome reaction (GO:0060046)2.49930540
157regulation of hexokinase activity (GO:1903299)2.49901826
158regulation of glucokinase activity (GO:0033131)2.49901826
159negative regulation of fibrinolysis (GO:0051918)2.49620376
160positive regulation of glycolytic process (GO:0045821)2.49558901
161bundle of His cell to Purkinje myocyte communication (GO:0086069)2.48003698
162intestinal epithelial cell development (GO:0060576)2.47917081
163positive regulation of peptide hormone secretion (GO:0090277)2.47696029
164imidazole-containing compound metabolic process (GO:0052803)2.47396561
165positive regulation of insulin secretion (GO:0032024)2.47211926
166regulation of complement activation (GO:0030449)2.46949770
167toxin metabolic process (GO:0009404)2.45381659
168kynurenine metabolic process (GO:0070189)2.43446401
169positive regulation of hormone metabolic process (GO:0032352)2.43184782
170cellular glucuronidation (GO:0052695)2.41186237
171positive regulation of cellular amine metabolic process (GO:0033240)2.40034404
172establishment of protein localization to Golgi (GO:0072600)2.39978710
173blood coagulation, intrinsic pathway (GO:0007597)2.39952924
174cellular modified amino acid catabolic process (GO:0042219)2.39241748
175protein-lipid complex assembly (GO:0065005)2.39117093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.45509468
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.22893874
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.61786820
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.24932903
5EGR1_23403033_ChIP-Seq_LIVER_Mouse2.90364993
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.86154932
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.79449446
8IGF1R_20145208_ChIP-Seq_DFB_Human2.71846150
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.71494685
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.35181133
11ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.33711206
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21988237
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19466053
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.12198068
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11283464
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97851882
17TAF15_26573619_Chip-Seq_HEK293_Human1.90337960
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89407849
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88305152
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.87400306
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.85759533
22GBX2_23144817_ChIP-Seq_PC3_Human1.83007441
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81130072
24CLOCK_20551151_ChIP-Seq_293T_Human1.79747207
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77662044
26FUS_26573619_Chip-Seq_HEK293_Human1.70385371
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70359947
28VDR_22108803_ChIP-Seq_LS180_Human1.69788707
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67894713
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67132171
31SMAD4_21799915_ChIP-Seq_A2780_Human1.66265035
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64765998
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64765998
34EWS_26573619_Chip-Seq_HEK293_Human1.62657495
35FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.59687369
36* E2F1_18555785_Chip-Seq_ESCs_Mouse1.54704569
37AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.53132749
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.51581653
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51151228
40* CMYC_18555785_Chip-Seq_ESCs_Mouse1.49796436
41* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47763624
42CBP_20019798_ChIP-Seq_JUKART_Human1.45744399
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45744399
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44270045
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43353606
46* P300_18555785_Chip-Seq_ESCs_Mouse1.41328512
47* OCT4_18555785_Chip-Seq_ESCs_Mouse1.40312308
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40284419
49CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40217846
50SOX2_20726797_ChIP-Seq_SW620_Human1.39796220
51* STAT3_18555785_Chip-Seq_ESCs_Mouse1.37915295
52* SOX2_18555785_Chip-Seq_ESCs_Mouse1.37815485
53* TCF4_23295773_ChIP-Seq_U87_Human1.37813393
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.37371758
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36743572
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.36554224
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36321631
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36102976
59* NMYC_18555785_Chip-Seq_ESCs_Mouse1.35004204
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34972320
61GATA1_22025678_ChIP-Seq_K562_Human1.34361624
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.34345993
63AR_25329375_ChIP-Seq_VCAP_Human1.33177237
64BCAT_22108803_ChIP-Seq_LS180_Human1.31339562
65TCF4_22108803_ChIP-Seq_LS180_Human1.31198824
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29801070
67* ZFX_18555785_Chip-Seq_ESCs_Mouse1.29448151
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27919870
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27902354
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24087551
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23846798
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22681083
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22521886
74* CTCF_18555785_Chip-Seq_ESCs_Mouse1.22085513
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21669980
76ELK1_19687146_ChIP-ChIP_HELA_Human1.21349132
77* EZH2_27294783_Chip-Seq_NPCs_Mouse1.21164004
78RUNX2_22187159_ChIP-Seq_PCA_Human1.20971643
79* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20156870
80* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16536261
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16121882
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15019440
83FOXA1_25552417_ChIP-Seq_VCAP_Human1.14765300
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.14627504
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14442182
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14060642
87* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13713160
88* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13437117
89GATA4_25053715_ChIP-Seq_YYC3_Human1.13384564
90* NANOG_19829295_ChIP-Seq_ESCs_Human1.13232034
91* SOX2_19829295_ChIP-Seq_ESCs_Human1.13232034
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12334059
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11769792
94* KLF4_18555785_Chip-Seq_ESCs_Mouse1.11721512
95CJUN_26792858_Chip-Seq_BT549_Human1.11147559
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.11002867
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10763192
98TP53_16413492_ChIP-PET_HCT116_Human1.10359891
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08667947
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07367327
101* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06478258
102HTT_18923047_ChIP-ChIP_STHdh_Human1.06448678
103ER_23166858_ChIP-Seq_MCF-7_Human1.03021470
104ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02226070
105ERG_20517297_ChIP-Seq_VCAP_Human1.01867492
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.01426667
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00580753
108* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99575417
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98254977
110* NFE2_27457419_Chip-Seq_LIVER_Mouse0.97955360
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97030158
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96704916
113* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96165271
114ZNF274_21170338_ChIP-Seq_K562_Hela0.94026968
115* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93386799
116* NANOG_18555785_Chip-Seq_ESCs_Mouse0.92657070
117FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92634175
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91787155
119* CRX_20693478_ChIP-Seq_RETINA_Mouse0.91597419
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91023116
121CDX2_22108803_ChIP-Seq_LS180_Human0.90952732
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.90510758
123AR_20517297_ChIP-Seq_VCAP_Human0.89729541
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89250267
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88832340
126GATA3_24758297_ChIP-Seq_MCF-7_Human0.88583820
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87050625
128TP63_23658742_ChIP-Seq_EP156T_Human0.85819802
129* P53_22387025_ChIP-Seq_ESCs_Mouse0.85797641
130* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85592167
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85392980
132NOTCH1_21737748_ChIP-Seq_TLL_Human0.85256711
133TP53_18474530_ChIP-ChIP_U2OS_Human0.85252779
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85182697
135* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.84484407
136* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84138358
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83831798
138STAT3_23295773_ChIP-Seq_U87_Human0.83148241
139NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82957946
140IRF8_22096565_ChIP-ChIP_GC-B_Human0.82934483
141RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82817547
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.81270781
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81204806
144SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80846708
145PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79632021
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.78667646
147P300_19829295_ChIP-Seq_ESCs_Human0.77986869

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.73930945
2MP0005365_abnormal_bile_salt4.09832925
3MP0003122_maternal_imprinting3.79504164
4MP0003195_calcinosis3.61357292
5MP0003252_abnormal_bile_duct3.31448181
6MP0005085_abnormal_gallbladder_physiolo3.19394418
7MP0008877_abnormal_DNA_methylation3.13715933
8MP0005220_abnormal_exocrine_pancreas3.04944007
9MP0003787_abnormal_imprinting2.77147150
10MP0002877_abnormal_melanocyte_morpholog2.66462111
11MP0001944_abnormal_pancreas_morphology2.60493657
12MP0005360_urolithiasis2.59846726
13MP0002693_abnormal_pancreas_physiology2.59567455
14MP0002138_abnormal_hepatobiliary_system2.56630573
15MP0010386_abnormal_urinary_bladder2.55593274
16MP0003868_abnormal_feces_composition2.47275878
17MP0003890_abnormal_embryonic-extraembry2.45447967
18MP0001666_abnormal_nutrient_absorption2.44676600
19MP0005083_abnormal_biliary_tract2.42573497
20MP0003121_genomic_imprinting2.40455749
21MP0002928_abnormal_bile_duct2.21638811
22MP0005379_endocrine/exocrine_gland_phen2.11509206
23MP0008875_abnormal_xenobiotic_pharmacok2.03572655
24MP0000013_abnormal_adipose_tissue1.99947683
25MP0005408_hypopigmentation1.88896752
26MP0000566_synostosis1.81226704
27MP0003300_gastrointestinal_ulcer1.77554025
28MP0000613_abnormal_salivary_gland1.72738718
29MP0000383_abnormal_hair_follicle1.63212381
30MP0009780_abnormal_chondrocyte_physiolo1.61174629
31MP0009384_cardiac_valve_regurgitation1.56269176
32MP0000427_abnormal_hair_cycle1.51847740
33MP0001661_extended_life_span1.49887817
34MP0004264_abnormal_extraembryonic_tissu1.46213399
35MP0008438_abnormal_cutaneous_collagen1.45407171
36MP0002638_abnormal_pupillary_reflex1.45115053
37MP0000516_abnormal_urinary_system1.45077017
38MP0005367_renal/urinary_system_phenotyp1.45077017
39MP0009643_abnormal_urine_homeostasis1.43442526
40MP0010678_abnormal_skin_adnexa1.41576540
41MP0002078_abnormal_glucose_homeostasis1.38742348
42MP0005248_abnormal_Harderian_gland1.38178748
43MP0008057_abnormal_DNA_replication1.36904407
44MP0000609_abnormal_liver_physiology1.35457369
45MP0000639_abnormal_adrenal_gland1.31885228
46MP0010352_gastrointestinal_tract_polyps1.31400413
47MP0004043_abnormal_pH_regulation1.31168130
48MP0000647_abnormal_sebaceous_gland1.29746441
49MP0005636_abnormal_mineral_homeostasis1.27608871
50MP0009840_abnormal_foam_cell1.27522123
51MP0000569_abnormal_digit_pigmentation1.27519088
52MP0005645_abnormal_hypothalamus_physiol1.25965455
53MP0006072_abnormal_retinal_apoptosis1.25582224
54MP0002163_abnormal_gland_morphology1.24268256
55MP0002896_abnormal_bone_mineralization1.24147775
56MP0000003_abnormal_adipose_tissue1.21298991
57MP0010329_abnormal_lipoprotein_level1.20413047
58MP0002282_abnormal_trachea_morphology1.20375132
59MP0005332_abnormal_amino_acid1.20365171
60MP0002118_abnormal_lipid_homeostasis1.18059236
61MP0003943_abnormal_hepatobiliary_system1.17883300
62MP0004134_abnormal_chest_morphology1.15941038
63MP0002168_other_aberrant_phenotype1.15766762
64MP0001765_abnormal_ion_homeostasis1.15451438
65MP0005084_abnormal_gallbladder_morpholo1.14986034
66MP0003283_abnormal_digestive_organ1.13957282
67MP0005058_abnormal_lysosome_morphology1.11211622
68MP0002295_abnormal_pulmonary_circulatio1.10835740
69MP0005253_abnormal_eye_physiology1.10594302
70MP0005409_darkened_coat_color1.10359487
71MP0005647_abnormal_sex_gland1.09638763
72MP0004381_abnormal_hair_follicle1.07951435
73MP0003724_increased_susceptibility_to1.07645521
74MP0000462_abnormal_digestive_system1.05034984
75MP0002166_altered_tumor_susceptibility1.04262198
76MP0003959_abnormal_lean_body1.02794735
77MP0005310_abnormal_salivary_gland1.02513823
78MP0010368_abnormal_lymphatic_system1.01458934
79MP0001986_abnormal_taste_sensitivity0.99288965
80MP0003183_abnormal_peptide_metabolism0.99083072
81MP0002909_abnormal_adrenal_gland0.98809131
82MP0004883_abnormal_blood_vessel0.98090466
83MP0002233_abnormal_nose_morphology0.97232024
84MP0001485_abnormal_pinna_reflex0.96817521
85MP0002060_abnormal_skin_morphology0.94294453
86MP0003045_fibrosis0.94035364
87MP0009697_abnormal_copulation0.93476267
88MP0004142_abnormal_muscle_tone0.93183567
89MP0001188_hyperpigmentation0.92005480
90MP0003795_abnormal_bone_structure0.90992191
91MP0003191_abnormal_cellular_cholesterol0.90868094
92MP0001879_abnormal_lymphatic_vessel0.89098276
93MP0002837_dystrophic_cardiac_calcinosis0.88597579
94MP0001756_abnormal_urination0.87557336
95MP0005395_other_phenotype0.87351709
96MP0001984_abnormal_olfaction0.87193846
97MP0005319_abnormal_enzyme/_coenzyme0.87061491
98MP0005334_abnormal_fat_pad0.84585836
99MP0005670_abnormal_white_adipose0.84466681
100MP0005257_abnormal_intraocular_pressure0.83743750
101MP0002396_abnormal_hematopoietic_system0.83582253
102MP0009379_abnormal_foot_pigmentation0.83157280
103MP0000163_abnormal_cartilage_morphology0.82161325
104MP0000538_abnormal_urinary_bladder0.82141672
105MP0005375_adipose_tissue_phenotype0.81978822
106MP0001299_abnormal_eye_distance/0.81516880
107MP0006054_spinal_hemorrhage0.80984790
108MP0001270_distended_abdomen0.80140868
109MP0005275_abnormal_skin_tensile0.80059916
110MP0003950_abnormal_plasma_membrane0.80019364
111MP0001881_abnormal_mammary_gland0.78601967
112MP0002938_white_spotting0.78351909
113MP0001243_abnormal_dermal_layer0.78225740
114MP0002102_abnormal_ear_morphology0.78159996
115MP0004272_abnormal_basement_membrane0.77841544
116MP0001533_abnormal_skeleton_physiology0.77337869
117MP0004133_heterotaxia0.77026746
118MP0003953_abnormal_hormone_level0.76901075
119MP0005503_abnormal_tendon_morphology0.76871374
120MP0000631_abnormal_neuroendocrine_gland0.76724790
121MP0005164_abnormal_response_to0.76075963
122MP0001286_abnormal_eye_development0.76029634
123MP0001764_abnormal_homeostasis0.75841620
124MP0001324_abnormal_eye_pigmentation0.74545482
125MP0008995_early_reproductive_senescence0.73903603
126MP0002933_joint_inflammation0.72514207
127MP0001529_abnormal_vocalization0.72083171
128MP0002876_abnormal_thyroid_physiology0.71144536
129MP0004019_abnormal_vitamin_homeostasis0.70913410
130MP0008469_abnormal_protein_level0.69731286
131MP0000598_abnormal_liver_morphology0.69562341
132MP0000377_abnormal_hair_follicle0.69237772
133MP0003186_abnormal_redox_activity0.69094809
134MP0003806_abnormal_nucleotide_metabolis0.67543237
135MP0003656_abnormal_erythrocyte_physiolo0.66974661
136MP0009642_abnormal_blood_homeostasis0.66943536
137MP0002115_abnormal_skeleton_extremities0.66284806
138MP0002127_abnormal_cardiovascular_syste0.66151641
139MP0002971_abnormal_brown_adipose0.65530731
140MP0002098_abnormal_vibrissa_morphology0.64703962
141MP0005391_vision/eye_phenotype0.64527538
142MP0005551_abnormal_eye_electrophysiolog0.63873560
143MP0001293_anophthalmia0.63617613
144MP0003937_abnormal_limbs/digits/tail_de0.61163746
145MP0002006_tumorigenesis0.61147144
146MP0002177_abnormal_outer_ear0.60401552
147MP0003936_abnormal_reproductive_system0.60399975
148MP0009764_decreased_sensitivity_to0.60385865
149MP0003011_delayed_dark_adaptation0.57968154
150MP0005666_abnormal_adipose_tissue0.55999525

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)6.11425661
2Hyperinsulinemic hypoglycemia (HP:0000825)5.62653043
3Hypoglycemic seizures (HP:0002173)5.17013368
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.78530242
5Intrahepatic cholestasis (HP:0001406)4.49649785
6Prolonged partial thromboplastin time (HP:0003645)4.40525686
7Abnormality of the intrinsic pathway (HP:0010989)4.38381492
8Papillary thyroid carcinoma (HP:0002895)4.36679728
9Symptomatic seizures (HP:0011145)4.32453260
10Abnormality of the common coagulation pathway (HP:0010990)4.08514883
11Hyperglycemia (HP:0003074)3.66817451
12Conjugated hyperbilirubinemia (HP:0002908)3.56312623
13Xanthomatosis (HP:0000991)3.49457774
14Ketoacidosis (HP:0001993)3.33261960
15Volvulus (HP:0002580)3.27429792
16Insulin-resistant diabetes mellitus (HP:0000831)3.19732191
17Chronic hepatic failure (HP:0100626)3.15297644
18Fat malabsorption (HP:0002630)3.03515685
19Bifid tongue (HP:0010297)2.98994925
20Thyroid carcinoma (HP:0002890)2.96931457
21Deep venous thrombosis (HP:0002625)2.96363579
22Abnormality of monocarboxylic acid metabolism (HP:0010996)2.94906156
23Ketosis (HP:0001946)2.87536240
24Generalized aminoaciduria (HP:0002909)2.86810232
25Abnormality of endocrine pancreas physiology (HP:0012093)2.84864868
26Abnormality of the pancreatic islet cells (HP:0006476)2.84864868
27Abnormal respiratory motile cilium physiology (HP:0012261)2.81607689
28Abnormal ciliary motility (HP:0012262)2.77537041
29Hypoproteinemia (HP:0003075)2.76368445
30Late onset (HP:0003584)2.72806533
31Metaphyseal dysplasia (HP:0100255)2.71768507
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.71198673
33Bile duct proliferation (HP:0001408)2.69498466
34Abnormal biliary tract physiology (HP:0012439)2.69498466
35Myocardial infarction (HP:0001658)2.65404269
36Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.62309527
37Back pain (HP:0003418)2.60654702
38Joint hemorrhage (HP:0005261)2.59713992
39Renal cortical cysts (HP:0000803)2.59658482
40Protuberant abdomen (HP:0001538)2.57247086
41Hydroxyprolinuria (HP:0003080)2.54976736
42Abnormality of proline metabolism (HP:0010907)2.54976736
43Broad alveolar ridges (HP:0000187)2.54917940
44Decreased circulating renin level (HP:0003351)2.54561531
45Tubulointerstitial nephritis (HP:0001970)2.46780553
46Genital tract atresia (HP:0001827)2.41197071
47Pancreatic cysts (HP:0001737)2.37803471
48Hypothermia (HP:0002045)2.37659545
49Hyperkalemia (HP:0002153)2.35528453
50Chronic bronchitis (HP:0004469)2.35173834
51Broad palm (HP:0001169)2.34996301
52Pancreatic islet-cell hyperplasia (HP:0004510)2.34933722
53Agitation (HP:0000713)2.33552252
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.31248229
55Hypobetalipoproteinemia (HP:0003563)2.28591328
56Epidermoid cyst (HP:0200040)2.25009795
57Medial flaring of the eyebrow (HP:0010747)2.24233181
58Vaginal atresia (HP:0000148)2.23776634
59Premature rupture of membranes (HP:0001788)2.22347660
60Molar tooth sign on MRI (HP:0002419)2.20978419
61Abnormality of midbrain morphology (HP:0002418)2.20978419
62Urinary glycosaminoglycan excretion (HP:0003541)2.20566105
63Mucopolysacchariduria (HP:0008155)2.20566105
64Thoracolumbar scoliosis (HP:0002944)2.20467304
65Abdominal distention (HP:0003270)2.20390889
66Rhinitis (HP:0012384)2.19261000
67Dysostosis multiplex (HP:0000943)2.18837814
68Beaking of vertebral bodies (HP:0004568)2.18780288
69Type I diabetes mellitus (HP:0100651)2.18027856
70Right ventricular cardiomyopathy (HP:0011663)2.16290169
71Steatorrhea (HP:0002570)2.14724850
72Hyperlipoproteinemia (HP:0010980)2.14208102
73Abnormality of the pubic bones (HP:0003172)2.13046099
74Papilledema (HP:0001085)2.12829741
75Skin nodule (HP:0200036)2.12026518
76True hermaphroditism (HP:0010459)2.10921539
77Abnormality of vitamin B metabolism (HP:0004340)2.09772339
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07906765
79Abnormality of polysaccharide metabolism (HP:0011012)2.07534914
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07534914
81Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07534914
82Vacuolated lymphocytes (HP:0001922)2.06946880
83Hypoplastic labia majora (HP:0000059)2.06257578
84Gingival bleeding (HP:0000225)2.05846594
85Joint swelling (HP:0001386)2.05801692
86Short nail (HP:0001799)2.02991360
87Gastrointestinal atresia (HP:0002589)2.02957512
88Congenital sensorineural hearing impairment (HP:0008527)2.01748915
89Insulin resistance (HP:0000855)1.99871626
90Abnormality of the renal medulla (HP:0100957)1.95874719
91Wide nose (HP:0000445)1.95872439
92Absent eyebrow (HP:0002223)1.95838531
93Pancreatitis (HP:0001733)1.95673981
94Abnormality of calcium-phosphate metabolism (HP:0100530)1.95430717
95Pheochromocytoma (HP:0002666)1.95147136
96Menorrhagia (HP:0000132)1.95144211
97Spontaneous abortion (HP:0005268)1.94817184
98Abnormal respiratory motile cilium morphology (HP:0005938)1.94230341
99Abnormal respiratory epithelium morphology (HP:0012253)1.94230341
100Testicular neoplasm (HP:0010788)1.93768776
101Abnormal biliary tract morphology (HP:0012440)1.93752338
102Congenital primary aphakia (HP:0007707)1.93120659
103Hyperglycinuria (HP:0003108)1.93045543
104Intestinal atresia (HP:0011100)1.92985236
105Abnormality of urine glucose concentration (HP:0011016)1.92644836
106Glycosuria (HP:0003076)1.92644836
107Arthropathy (HP:0003040)1.92556028
108Hypolipoproteinemia (HP:0010981)1.92506186
109Abnormality of purine metabolism (HP:0004352)1.91908586
110Abnormality of vitamin metabolism (HP:0100508)1.90263083
111Elevated alkaline phosphatase (HP:0003155)1.89782848
112Abnormality of the renal cortex (HP:0011035)1.89668350
113Exocrine pancreatic insufficiency (HP:0001738)1.89093237
114Macroorchidism (HP:0000053)1.88326091
115Neurofibrillary tangles (HP:0002185)1.88140301
116Large for gestational age (HP:0001520)1.87258181
117Restlessness (HP:0000711)1.86823022
118Bell-shaped thorax (HP:0001591)1.86525664
119Nephrogenic diabetes insipidus (HP:0009806)1.86025768
120Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85774072
121Hyperphosphatemia (HP:0002905)1.85385981
122Pancreatic fibrosis (HP:0100732)1.85163909
123Hyperglycinemia (HP:0002154)1.84883989
124Hypoalphalipoproteinemia (HP:0003233)1.84529564
125Dicarboxylic aciduria (HP:0003215)1.83208329
126Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83208329
127Submucous cleft hard palate (HP:0000176)1.82702883
128Tubular atrophy (HP:0000092)1.82150581
129Abnormality of the nasal septum (HP:0000419)1.80837055
130Nephronophthisis (HP:0000090)1.80481194
131Abnormality of serine family amino acid metabolism (HP:0010894)1.80075801
132Abnormality of glycine metabolism (HP:0010895)1.80075801
133Hypoplastic ischia (HP:0003175)1.79861487
134Male infertility (HP:0003251)1.79750161
135Gait imbalance (HP:0002141)1.78872959
136Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78869064
137Gonadal dysgenesis (HP:0000133)1.78287295
138Proximal tubulopathy (HP:0000114)1.77980867
139Abnormality of incisor morphology (HP:0011063)1.77681236
140Sex reversal (HP:0012245)1.77335113
141Abnormal sex determination (HP:0012244)1.77335113
142Facial hemangioma (HP:0000329)1.76869187
143Retinal atrophy (HP:0001105)1.76542978
144Alacrima (HP:0000522)1.76151750
145Male pseudohermaphroditism (HP:0000037)1.75882360
146Cystic liver disease (HP:0006706)1.75842797
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.74790143
148Abnormal enzyme/coenzyme activity (HP:0012379)1.74702108
149Posterior subcapsular cataract (HP:0007787)1.73062584
150Menstrual irregularities (HP:0000858)1.71919985
151Enlarged kidneys (HP:0000105)1.71179398
152Abnormality of alkaline phosphatase activity (HP:0004379)1.70523052
153Bronchiectasis (HP:0002110)1.69491352
154Tubulointerstitial abnormality (HP:0001969)1.69126730
155Hypoplasia of dental enamel (HP:0006297)1.67194818
156Abnormality of potassium homeostasis (HP:0011042)1.66706184
157Complement deficiency (HP:0004431)1.66366415
158Abnormality of the vitamin B12 metabolism (HP:0004341)1.66306554
159Neuroendocrine neoplasm (HP:0100634)1.64792711
160Abnormality of the labia majora (HP:0012881)1.62311770
161Osteomalacia (HP:0002749)1.61582153
162Wide intermamillary distance (HP:0006610)1.61082327
163Abnormal delivery (HP:0001787)1.61024001
164Blepharitis (HP:0000498)1.60922672
165Anophthalmia (HP:0000528)1.60820103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.85176868
2INSRR4.47262716
3MAPK153.77166858
4FRK3.16415762
5BCR3.10979392
6NUAK13.01706039
7ERN12.93352293
8IRAK32.53704925
9PASK2.44822830
10PIK3CG2.42118049
11TRIM282.28708325
12EPHA32.28133226
13LATS12.24188594
14TNIK2.16715062
15SIK22.13888034
16SIK12.09575869
17IRAK12.05021369
18ACVR1B1.91129247
19BCKDK1.89480010
20AKT31.87472605
21ERBB31.84828847
22PDK21.73682721
23PNCK1.68875407
24IRAK41.66333907
25PIK3CA1.65114561
26HIPK21.64805218
27WNK41.59698901
28MAP2K61.56061879
29STK241.33892067
30FGFR41.32437711
31FGFR11.32092155
32FLT31.31181690
33EPHB11.28291708
34CASK1.26106305
35MAP3K121.25184843
36MAP3K21.23426635
37CAMK1G1.20018442
38NLK1.17829296
39PBK1.13951337
40GRK11.11817464
41STK391.07575863
42PTK61.06451810
43TXK1.03616004
44MAP3K41.02860130
45IRAK21.01460639
46PDGFRA1.00083008
47TRPM71.00009521
48JAK30.97897653
49BRSK20.97696333
50MET0.96542460
51ERBB40.95838216
52YES10.92105949
53MKNK10.91273578
54TEC0.88280311
55PTK20.87543221
56BMPR1B0.85996569
57DYRK1B0.85985863
58MAP2K20.85742829
59PAK30.84649102
60FER0.84149562
61DMPK0.81701390
62WNK10.81652519
63OXSR10.81638947
64EIF2AK10.80975735
65TBK10.80447279
66GRK70.80199009
67NME20.78672244
68MST1R0.78267512
69MUSK0.77919987
70JAK10.76965468
71CHUK0.72597382
72CAMK1D0.72479229
73MST40.72010521
74GSK3A0.71594291
75WNK30.68026024
76ABL20.67901779
77PRKAA20.67759852
78STK38L0.67725976
79CSF1R0.67684569
80EIF2AK30.66853450
81PIM20.66133687
82BLK0.65347689
83CDK30.63184022
84SCYL20.62027631
85ATM0.61521365
86NEK90.60895068
87MAP3K10.59768711
88TYK20.59576565
89NTRK10.59434439
90MAPKAPK50.59404360
91CSNK1G10.58616487
92ERBB20.58458005
93PDGFRB0.57947723
94EPHA20.57605822
95CDC42BPA0.55304312
96PAK20.55196111
97STK30.55044741
98PINK10.54408163
99JAK20.52829370
100BMPR20.52545556
101EIF2AK20.52195313
102MKNK20.51390460
103PLK20.50702991
104CSNK1E0.50599116
105STK160.50385710
106MAP3K140.49538202
107IKBKE0.49079572
108ROCK10.48951469
109PRKCE0.48810047
110TGFBR10.48528358
111LMTK20.48181541
112KDR0.47962359
113CSNK1A1L0.47065928
114CSNK1D0.44836242
115MAP4K20.44807564
116SIK30.44297536
117NEK60.44201461
118MAP2K70.43308964
119FGFR20.42699648
120CSK0.42662703
121IGF1R0.39850117
122MAP3K30.39618245
123PRKCQ0.38587655
124CSNK1A10.37534401
125MTOR0.37303348
126PRKACB0.37246739
127ITK0.36023417
128ABL10.35836013
129RPS6KA40.35555798
130BRD40.35304890
131MYLK0.35088960
132NEK20.34321906
133DYRK1A0.34216183
134DDR20.33892971
135CDK90.33086187
136FGFR30.32757991
137TIE10.32736119
138BTK0.32559083
139MAPK100.32315922
140PRKG10.32135347
141PRKACA0.32020478
142RPS6KA50.31947453
143KIT0.31893679
144WEE10.30972645
145EGFR0.30823489
146PRKDC0.28994356
147SGK10.28404130
148PRKACG0.28397758

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.18965455
2Protein export_Homo sapiens_hsa030605.42895916
3Sulfur metabolism_Homo sapiens_hsa009203.21429696
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.09815054
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.45858091
6Tryptophan metabolism_Homo sapiens_hsa003802.33810282
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11884210
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96669498
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93871608
10Selenocompound metabolism_Homo sapiens_hsa004501.92270329
11Complement and coagulation cascades_Homo sapiens_hsa046101.92058393
12Histidine metabolism_Homo sapiens_hsa003401.90737697
13Folate biosynthesis_Homo sapiens_hsa007901.88113151
14Butanoate metabolism_Homo sapiens_hsa006501.75208161
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68805926
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60948663
17Steroid biosynthesis_Homo sapiens_hsa001001.51671481
18Fatty acid degradation_Homo sapiens_hsa000711.47563227
19Peroxisome_Homo sapiens_hsa041461.44022926
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36614957
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36046876
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34222444
23Tyrosine metabolism_Homo sapiens_hsa003501.31099460
24Circadian rhythm_Homo sapiens_hsa047101.28298233
25ABC transporters_Homo sapiens_hsa020101.27662404
26Fat digestion and absorption_Homo sapiens_hsa049751.20837255
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20389177
28Phenylalanine metabolism_Homo sapiens_hsa003601.19509753
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19415657
30Starch and sucrose metabolism_Homo sapiens_hsa005001.18300373
31Caffeine metabolism_Homo sapiens_hsa002321.14934361
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.13908639
33beta-Alanine metabolism_Homo sapiens_hsa004101.10668293
34Retinol metabolism_Homo sapiens_hsa008301.07923461
35Fatty acid elongation_Homo sapiens_hsa000621.05884691
36Propanoate metabolism_Homo sapiens_hsa006401.04102637
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02083542
38Nitrogen metabolism_Homo sapiens_hsa009101.01789347
39Vitamin digestion and absorption_Homo sapiens_hsa049771.01558009
40Glycosaminoglycan degradation_Homo sapiens_hsa005310.99108393
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97434905
42Staphylococcus aureus infection_Homo sapiens_hsa051500.96644784
43Chemical carcinogenesis_Homo sapiens_hsa052040.93194535
44Lysosome_Homo sapiens_hsa041420.93110201
45N-Glycan biosynthesis_Homo sapiens_hsa005100.90615229
46Pancreatic secretion_Homo sapiens_hsa049720.88932116
47PPAR signaling pathway_Homo sapiens_hsa033200.87321218
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84316581
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82778219
50Protein digestion and absorption_Homo sapiens_hsa049740.80819944
51Insulin secretion_Homo sapiens_hsa049110.80557847
52Arginine and proline metabolism_Homo sapiens_hsa003300.79651143
53Sphingolipid metabolism_Homo sapiens_hsa006000.78841979
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76418310
55Linoleic acid metabolism_Homo sapiens_hsa005910.76011321
56Fatty acid metabolism_Homo sapiens_hsa012120.75946239
57TGF-beta signaling pathway_Homo sapiens_hsa043500.74403415
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74203642
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71459442
60Other glycan degradation_Homo sapiens_hsa005110.68641174
61Basal transcription factors_Homo sapiens_hsa030220.67311282
62Type I diabetes mellitus_Homo sapiens_hsa049400.66880474
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.65991901
64Ovarian steroidogenesis_Homo sapiens_hsa049130.65805095
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.64829471
66Lysine degradation_Homo sapiens_hsa003100.64425013
67Glutathione metabolism_Homo sapiens_hsa004800.63931252
68Insulin resistance_Homo sapiens_hsa049310.63708481
69Prion diseases_Homo sapiens_hsa050200.62117256
70Vibrio cholerae infection_Homo sapiens_hsa051100.61302032
71Bile secretion_Homo sapiens_hsa049760.58711686
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57615753
73RNA degradation_Homo sapiens_hsa030180.54655001
74Mineral absorption_Homo sapiens_hsa049780.53200190
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52009239
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51366106
77Glycerolipid metabolism_Homo sapiens_hsa005610.50004392
78Prolactin signaling pathway_Homo sapiens_hsa049170.49548284
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49125240
80Prostate cancer_Homo sapiens_hsa052150.48630997
81ECM-receptor interaction_Homo sapiens_hsa045120.48407542
82Arginine biosynthesis_Homo sapiens_hsa002200.47567584
83Cocaine addiction_Homo sapiens_hsa050300.46137634
84Thyroid hormone synthesis_Homo sapiens_hsa049180.44581723
85Glucagon signaling pathway_Homo sapiens_hsa049220.44166406
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42051938
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41384000
88Dorso-ventral axis formation_Homo sapiens_hsa043200.39472753
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39173556
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36491148
91African trypanosomiasis_Homo sapiens_hsa051430.35338218
92Metabolic pathways_Homo sapiens_hsa011000.34575861
93Type II diabetes mellitus_Homo sapiens_hsa049300.33283903
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32966351
95Regulation of autophagy_Homo sapiens_hsa041400.32360739
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30248477
97Ether lipid metabolism_Homo sapiens_hsa005650.29913868
98Arachidonic acid metabolism_Homo sapiens_hsa005900.29685098
99Phototransduction_Homo sapiens_hsa047440.29127471
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.27990253
101Renin-angiotensin system_Homo sapiens_hsa046140.25378997
102Vitamin B6 metabolism_Homo sapiens_hsa007500.25157398
103mRNA surveillance pathway_Homo sapiens_hsa030150.25000792
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23782381
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22958591
106Dopaminergic synapse_Homo sapiens_hsa047280.21219452
107Sulfur relay system_Homo sapiens_hsa041220.20462926
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.20208720
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20146367
110Serotonergic synapse_Homo sapiens_hsa047260.20032197
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19724019
112Pyruvate metabolism_Homo sapiens_hsa006200.19451901
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19420647
114Hedgehog signaling pathway_Homo sapiens_hsa043400.19351526
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18942670
116Phagosome_Homo sapiens_hsa041450.18409533
117Non-homologous end-joining_Homo sapiens_hsa034500.18255260
118Nucleotide excision repair_Homo sapiens_hsa034200.16576784
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16480906
120Hippo signaling pathway_Homo sapiens_hsa043900.16477186
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16054604
122Adherens junction_Homo sapiens_hsa045200.14837183
123Fanconi anemia pathway_Homo sapiens_hsa034600.13804441
124Long-term depression_Homo sapiens_hsa047300.11314590
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10190100

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