UBXN6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.27195390
2cell wall macromolecule catabolic process (GO:0016998)9.25390711
3cell wall macromolecule metabolic process (GO:0044036)9.25390711
4acrosome assembly (GO:0001675)9.01338403
5binding of sperm to zona pellucida (GO:0007339)8.71789472
6spermatid development (GO:0007286)8.20203976
7cell-cell recognition (GO:0009988)8.16002486
8axonemal dynein complex assembly (GO:0070286)7.94321578
9epithelial cilium movement (GO:0003351)7.90743387
10plasma membrane fusion (GO:0045026)7.69467015
11cilium or flagellum-dependent cell motility (GO:0001539)7.58404166
12multicellular organism reproduction (GO:0032504)7.46097350
13motile cilium assembly (GO:0044458)7.35285400
14regulation of cilium movement (GO:0003352)7.20564995
15reproduction (GO:0000003)6.76293272
16piRNA metabolic process (GO:0034587)6.74644853
17synaptonemal complex organization (GO:0070193)6.72159347
18synaptonemal complex assembly (GO:0007130)6.60763833
19cilium movement (GO:0003341)6.34539596
20male meiosis (GO:0007140)6.02836286
21negative regulation of inclusion body assembly (GO:0090084)5.69819030
22organic cation transport (GO:0015695)5.67635119
23spermatogenesis (GO:0007283)5.57883748
24male gamete generation (GO:0048232)5.56342858
25sperm capacitation (GO:0048240)5.53983868
26single fertilization (GO:0007338)5.45247167
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.40366692
28regulation of inclusion body assembly (GO:0090083)5.30948064
29gamete generation (GO:0007276)5.06876002
30calcium ion-dependent exocytosis (GO:0017156)4.86114919
31microtubule severing (GO:0051013)4.85760377
32fertilization (GO:0009566)4.79045419
33negative regulation of cell killing (GO:0031342)4.76338191
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.76338191
35DNA methylation involved in gamete generation (GO:0043046)4.76311369
36regulation of microtubule-based movement (GO:0060632)4.69512490
37male meiosis I (GO:0007141)4.66643275
38germ cell development (GO:0007281)4.64888387
39cellular process involved in reproduction in multicellular organism (GO:0022412)4.50477689
40seminiferous tubule development (GO:0072520)4.48012216
41chromosome condensation (GO:0030261)4.43714317
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.41445274
43microtubule depolymerization (GO:0007019)4.40774437
44spermatid nucleus differentiation (GO:0007289)4.36280984
45negative regulation of erythrocyte differentiation (GO:0045647)4.35214862
46sexual reproduction (GO:0019953)4.31978999
47chromosome organization involved in meiosis (GO:0070192)4.29512000
48left/right pattern formation (GO:0060972)4.19304951
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.10319148
50sequestering of actin monomers (GO:0042989)4.07326738
51DNA packaging (GO:0006323)4.06453966
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.04140240
53positive regulation by organism of defense response of other organism involved in symbiotic interact4.04140240
54modulation by symbiont of host immune response (GO:0052553)4.04140240
55positive regulation by symbiont of host defense response (GO:0052509)4.04140240
56modulation by symbiont of host defense response (GO:0052031)4.04140240
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.04140240
58chaperone-mediated protein complex assembly (GO:0051131)4.00927532
59cell recognition (GO:0008037)4.00657938
60oxygen transport (GO:0015671)3.94994704
61meiosis I (GO:0007127)3.94623721
62ventricular system development (GO:0021591)3.92855402
63multicellular organismal reproductive process (GO:0048609)3.92026314
64meiotic nuclear division (GO:0007126)3.84179677
65antigen processing and presentation of endogenous antigen (GO:0019883)3.81292017
66glycerol ether metabolic process (GO:0006662)3.73862408
67protein polyglutamylation (GO:0018095)3.72277277
68antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70530353
69positive regulation of gamma-delta T cell activation (GO:0046645)3.62758841
70macrophage activation involved in immune response (GO:0002281)3.59257430
71single strand break repair (GO:0000012)3.58984252
72gas transport (GO:0015669)3.49850423
73neutrophil activation involved in immune response (GO:0002283)3.45653351
74polyamine biosynthetic process (GO:0006596)3.44842461
75multicellular organismal development (GO:0007275)3.43838129
76ether metabolic process (GO:0018904)3.41401085
77detection of other organism (GO:0098543)3.41326351
78detection of bacterium (GO:0016045)3.37161786
79GTP biosynthetic process (GO:0006183)3.27484967
80carnitine transport (GO:0015879)3.25885803
81amino-acid betaine transport (GO:0015838)3.25885803
82DNA deamination (GO:0045006)3.24216019
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.23282779
84negative regulation of organelle assembly (GO:1902116)3.22104578
85positive thymic T cell selection (GO:0045059)3.17068757
86guanosine-containing compound biosynthetic process (GO:1901070)3.14392965
87carnitine transmembrane transport (GO:1902603)3.14356378
88response to peptidoglycan (GO:0032494)3.14016967
89nucleoside diphosphate phosphorylation (GO:0006165)3.11673765
90hemoglobin metabolic process (GO:0020027)3.02395649
91detection of external biotic stimulus (GO:0098581)3.00066263
92mannose metabolic process (GO:0006013)2.99211899
93modulation by virus of host process (GO:0019054)2.97706247
94modulation by symbiont of host cellular process (GO:0044068)2.95762553
95regulation of mast cell degranulation (GO:0043304)2.94789375
96UTP biosynthetic process (GO:0006228)2.94782054
97regulation of cilium assembly (GO:1902017)2.90966112
98nucleosome disassembly (GO:0006337)2.90908946
99protein-DNA complex disassembly (GO:0032986)2.90908946
100regulation of leukocyte degranulation (GO:0043300)2.87795536
101regulation of T-helper 2 cell differentiation (GO:0045628)2.86902911
102glycolytic process (GO:0006096)2.86693595
103regulation of myeloid leukocyte mediated immunity (GO:0002886)2.86670214
104regulation of protein kinase C signaling (GO:0090036)2.85883558
105meiotic cell cycle (GO:0051321)2.84494446
106regulation of B cell receptor signaling pathway (GO:0050855)2.83894073
107negative regulation of interleukin-12 production (GO:0032695)2.83797326
108alditol metabolic process (GO:0019400)2.83154074
109regulation of interferon-beta biosynthetic process (GO:0045357)2.82199011
110leukocyte aggregation (GO:0070486)2.80856492
111negative regulation of lymphocyte mediated immunity (GO:0002707)2.80412198
112chromatin silencing (GO:0006342)2.79682889
113negative regulation of leukocyte mediated immunity (GO:0002704)2.79649345
114detection of molecule of bacterial origin (GO:0032490)2.78455345
115protein localization to cilium (GO:0061512)2.77990003
116positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75641273
117mitochondrion degradation (GO:0000422)2.73130619
118positive regulation of fibroblast migration (GO:0010763)2.71258179
119protein insertion into membrane (GO:0051205)2.70255999
120UTP metabolic process (GO:0046051)2.66806762
121pyrimidine dimer repair (GO:0006290)2.66767034
122regulation of gamma-delta T cell activation (GO:0046643)2.66496499
123CDP-diacylglycerol metabolic process (GO:0046341)2.65482850
124regulation of oxidative phosphorylation (GO:0002082)2.64734035
125RNA localization (GO:0006403)2.64607086
126viral transcription (GO:0019083)2.64514152
127positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.63689564
128CTP metabolic process (GO:0046036)2.62947365
129CTP biosynthetic process (GO:0006241)2.62947365
130axoneme assembly (GO:0035082)2.61685533
131protein localization to endosome (GO:0036010)2.61338235
132response to host immune response (GO:0052572)2.60535883
133response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60535883
134regulation of regulated secretory pathway (GO:1903305)2.60377981
135regulation of necrotic cell death (GO:0010939)2.60330423
136response to muramyl dipeptide (GO:0032495)2.59999644
137cellular response to virus (GO:0098586)2.59941083
138myeloid cell activation involved in immune response (GO:0002275)2.57603299
139regulation of mast cell activation involved in immune response (GO:0033006)2.57295737
140regulation of platelet aggregation (GO:0090330)2.55905255
141macrophage activation (GO:0042116)2.55521432
142genitalia morphogenesis (GO:0035112)2.54635109
143regulation of spindle checkpoint (GO:0090231)2.53926137
144detection of biotic stimulus (GO:0009595)2.53807748
145CDP-diacylglycerol biosynthetic process (GO:0016024)2.53278680
146regulation of necroptotic process (GO:0060544)2.52543099
147regulation of ARF protein signal transduction (GO:0032012)2.51591936
148negative regulation of type 2 immune response (GO:0002829)2.49440104
149pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.49281381
150response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.49246997
151response to host (GO:0075136)2.49246997
152response to host defenses (GO:0052200)2.49246997
153protein complex localization (GO:0031503)2.48669440
154meiotic cell cycle process (GO:1903046)2.46379067
155translational elongation (GO:0006414)2.46135821
156synapsis (GO:0007129)2.45728230
157response to acidic pH (GO:0010447)2.44453045
158protein refolding (GO:0042026)2.44359801
159adenosine receptor signaling pathway (GO:0001973)2.44330493
160microglial cell activation (GO:0001774)2.44281170
161positive regulation of receptor recycling (GO:0001921)2.44171427
162germinal center formation (GO:0002467)2.43736990
163lipopolysaccharide-mediated signaling pathway (GO:0031663)2.41688606
164positive regulation of Rap GTPase activity (GO:0032854)2.41316099
165immunoglobulin mediated immune response (GO:0016064)2.39783097
166positive T cell selection (GO:0043368)2.39135449
167regulation of ARF GTPase activity (GO:0032312)2.37265302
168negative regulation of phagocytosis (GO:0050765)2.37254524
169regulation of gamma-delta T cell differentiation (GO:0045586)2.36117627
170granulocyte activation (GO:0036230)2.35918100
171thymic T cell selection (GO:0045061)2.35247436
172positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.34668752
173cellular extravasation (GO:0045123)2.34182447
174regulation of response to osmotic stress (GO:0047484)2.33747296
175barbed-end actin filament capping (GO:0051016)2.32396433
176regulation of early endosome to late endosome transport (GO:2000641)2.32347500
177negative regulation of T cell mediated immunity (GO:0002710)2.31751533
178negative regulation of granulocyte differentiation (GO:0030853)2.31622172
179neutrophil activation (GO:0042119)2.29964943
180response to type I interferon (GO:0034340)2.29773247
181negative regulation of innate immune response (GO:0045824)2.29463468
182negative regulation of toll-like receptor signaling pathway (GO:0034122)2.29352927
183erythrocyte development (GO:0048821)2.29121860
184positive regulation of Cdc42 GTPase activity (GO:0043089)2.29074451
185negative regulation of interleukin-6 production (GO:0032715)2.28920546
186B cell receptor signaling pathway (GO:0050853)2.28647928
187protoporphyrinogen IX metabolic process (GO:0046501)2.27690640
188cellular response to type I interferon (GO:0071357)2.27569734
189type I interferon signaling pathway (GO:0060337)2.27569734
190protein targeting to plasma membrane (GO:0072661)2.27045415
191positive regulation of mast cell activation (GO:0033005)2.25856346
192negative regulation of necrotic cell death (GO:0060547)2.25111141
193negative regulation of cAMP-mediated signaling (GO:0043951)2.23897197
194negative regulation of necroptotic process (GO:0060546)2.23322885
195positive regulation of protein dephosphorylation (GO:0035307)2.23112148
196cellular response to epinephrine stimulus (GO:0071872)2.19718010
197positive regulation of cellular amide metabolic process (GO:0034250)2.19323588
198sperm motility (GO:0030317)11.3933251
199acrosome reaction (GO:0007340)10.2522700
200fusion of sperm to egg plasma membrane (GO:0007342)10.0312132

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.18342727
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.58424005
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.19758377
4EZH2_22144423_ChIP-Seq_EOC_Human3.17849404
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.96827654
6* VDR_21846776_ChIP-Seq_THP-1_Human2.95379635
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.70972853
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.48817962
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37736765
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35534218
11KDM2B_26808549_Chip-Seq_DND41_Human2.28480831
12TET1_21451524_ChIP-Seq_MESCs_Mouse2.27674595
13SRY_22984422_ChIP-ChIP_TESTIS_Rat2.27181961
14* ELK3_25401928_ChIP-Seq_HUVEC_Human2.25550151
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.19070305
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.17011055
17YY1_22570637_ChIP-Seq_MALME-3M_Human2.12465581
18TCF7_22412390_ChIP-Seq_EML_Mouse2.12049139
19* VDR_24763502_ChIP-Seq_THP-1_Human2.10610032
20* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.05793889
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.02369284
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01403567
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.99096054
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95209771
25MYC_22102868_ChIP-Seq_BL_Human1.95065814
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90749456
27KDM2B_26808549_Chip-Seq_K562_Human1.89867787
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.87881529
29GATA1_19941826_ChIP-Seq_K562_Human1.85288910
30CTCF_18555785_ChIP-Seq_MESCs_Mouse1.84939952
31SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.83418638
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82432504
33* RACK7_27058665_Chip-Seq_MCF-7_Human1.79536752
34MAF_26560356_Chip-Seq_TH1_Human1.75227555
35GATA1_19941827_ChIP-Seq_MEL_Mouse1.75209245
36SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.72221367
37* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.67480646
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.65477069
39BCL6_27268052_Chip-Seq_Bcells_Human1.64262271
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62256157
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59255914
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.59200609
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.57975804
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57870112
45ZNF263_19887448_ChIP-Seq_K562_Human1.57374893
46PHF8_20622854_ChIP-Seq_HELA_Human1.56207251
47* MAF_26560356_Chip-Seq_TH2_Human1.55583966
48* UTX_26944678_Chip-Seq_JUKART_Human1.54821875
49SCL_19346495_ChIP-Seq_HPC-7_Human1.54682694
50P68_20966046_ChIP-Seq_HELA_Human1.53747986
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53648698
52BCOR_27268052_Chip-Seq_Bcells_Human1.52928588
53GATA3_21867929_ChIP-Seq_CD8_Mouse1.52840004
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52187047
55SPI1_23127762_ChIP-Seq_K562_Human1.51800103
56SOX2_22085726_ChIP-Seq_NPCs_Mouse1.51274226
57CTCF_20526341_ChIP-Seq_ESCs_Human1.50268145
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50131716
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.49659441
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49587183
61LXR_22292898_ChIP-Seq_THP-1_Human1.48803736
62CTCF_27219007_Chip-Seq_Bcells_Human1.47965373
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.47535578
64FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47018976
65E2F1_20622854_ChIP-Seq_HELA_Human1.46981880
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46029975
67RAD21_21589869_ChIP-Seq_MESCs_Mouse1.45385643
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45326677
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45247076
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44853624
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43898644
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43845815
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42726213
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42568567
75FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40335063
76ZNF274_21170338_ChIP-Seq_K562_Hela1.40210907
77P53_21459846_ChIP-Seq_SAOS-2_Human1.39731425
78SMC4_20622854_ChIP-Seq_HELA_Human1.38984891
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38501440
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38313829
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36270145
82TP63_17297297_ChIP-ChIP_HaCaT_Human1.35394139
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34814603
84CTCF_26484167_Chip-Seq_Bcells_Mouse1.33999913
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.32629193
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.32442229
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32161617
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30311944
89REST_21632747_ChIP-Seq_MESCs_Mouse1.30056579
90* FOXP1_21924763_ChIP-Seq_HESCs_Human1.30054602
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29557455
92ELK4_26923725_Chip-Seq_MESODERM_Mouse1.29427710
93MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29372469
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.29162058
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29155845
96SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27902647
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27011869
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26535169
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24898927
100SOX2_21211035_ChIP-Seq_LN229_Human1.24339617
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23987997
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23191303
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22956388
104* CREB1_26743006_Chip-Seq_LNCaP_Human1.22897478
105SPI1_20517297_ChIP-Seq_HL60_Human1.22833926
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22645540
107DROSHA_22980978_ChIP-Seq_HELA_Human1.21722123
108RARA_24833708_ChIP-Seq_LIVER_Mouse1.21654823
109MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21124312
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20980216
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20046191
112ERA_21632823_ChIP-Seq_H3396_Human1.19980517
113NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18740712
114JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.18528929
115YY1_21170310_ChIP-Seq_MESCs_Mouse1.17776370
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17087662
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.15820829
118RUNX_20019798_ChIP-Seq_JUKART_Human1.15137207
119SA1_27219007_Chip-Seq_Bcells_Human1.14941928
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14855687
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14346377
122SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14181566
123NCOR1_26117541_ChIP-Seq_K562_Human1.13346697
124* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12912779
125GATA2_19941826_ChIP-Seq_K562_Human1.12725335
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11703530
127MYC_27129775_Chip-Seq_CORNEA_Mouse1.11186417
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11137401
129* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10264115
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09576461
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09380774
132SPI1_26923725_Chip-Seq_HPCs_Mouse1.08929437
133DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08724351
134RAC3_21632823_ChIP-Seq_H3396_Human1.08624050
135PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08031847
136RARB_24833708_ChIP-Seq_LIVER_Mouse1.07638741
137PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07581388
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07264262
139TP63_22573176_ChIP-Seq_HFKS_Human1.07170882
140FLI1_21867929_ChIP-Seq_CD8_Mouse1.06928066
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06895015
142STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06283914
143PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05873813
144* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05631849
145CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05429705
146CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05325618
147STAT1_20625510_ChIP-Seq_HELA_Human1.05196073
148NANOG_20526341_ChIP-Seq_ESCs_Human1.04585455
149EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04501400
150LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03761785
151SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.03746695
152CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03605453
153WDR5_24793694_ChIP-Seq_LNCAP_Human1.03559330
154* OCT4_19829295_ChIP-Seq_ESCs_Human1.02750032
155HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02634381
156STAT1_17558387_ChIP-Seq_HELA_Human1.01177588
157* ETS1_20019798_ChIP-Seq_JURKAT_Human1.00894215
158EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00231414
159EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99840900
160TP53_22127205_ChIP-Seq_IMR90_Human0.99577331
161GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99317981
162E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98262461
163SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98215380
164SOX11_22085726_ChIP-Seq_ESNs_Mouse0.98083361
165SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96973988
166KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96550119
167RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95743966
168BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95257872
169GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95213638
170SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94873670
171LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94181332
172EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93747006
173SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93491380

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.82779526
2MP0001929_abnormal_gametogenesis4.39252904
3MP0003303_peritoneal_inflammation3.65862924
4MP0002653_abnormal_ependyma_morphology3.59934715
5MP0003436_decreased_susceptibility_to3.48145056
6MP0003724_increased_susceptibility_to2.90512205
7MP0003646_muscle_fatigue2.88900276
8MP0005670_abnormal_white_adipose2.87687878
9MP0002210_abnormal_sex_determination2.77490035
10MP0002161_abnormal_fertility/fecundity2.62270447
11MP0008877_abnormal_DNA_methylation2.44426378
12MP0003705_abnormal_hypodermis_morpholog2.39745113
13MP0001145_abnormal_male_reproductive2.38817035
14MP0005058_abnormal_lysosome_morphology2.35375703
15MP0003172_abnormal_lysosome_physiology2.33566452
16MP0005451_abnormal_body_composition2.29360019
17MP0008260_abnormal_autophagy2.24541665
18MP0003191_abnormal_cellular_cholesterol2.20519774
19MP0002419_abnormal_innate_immunity2.20205379
20MP0000685_abnormal_immune_system2.17708471
21MP0003011_delayed_dark_adaptation2.17240687
22MP0004510_myositis2.11212371
23MP0003300_gastrointestinal_ulcer2.09744060
24MP0005025_abnormal_response_to2.09405001
25MP0009278_abnormal_bone_marrow2.04900786
26MP0000653_abnormal_sex_gland2.00713374
27MP0005410_abnormal_fertilization12.3563130
28MP0004130_abnormal_muscle_cell1.99659490
29MP0006082_CNS_inflammation1.99541720
30MP0005083_abnormal_biliary_tract1.94766080
31MP0003656_abnormal_erythrocyte_physiolo1.88476774
32MP0005000_abnormal_immune_tolerance1.87210940
33MP0001790_abnormal_immune_system1.87065164
34MP0005387_immune_system_phenotype1.87065164
35MP0001835_abnormal_antigen_presentation1.85932642
36MP0005464_abnormal_platelet_physiology1.82865241
37MP0001533_abnormal_skeleton_physiology1.80076961
38MP0002160_abnormal_reproductive_system1.73683332
39MP0000751_myopathy1.71759028
40MP0004947_skin_inflammation1.68552668
41MP0009785_altered_susceptibility_to1.68315751
42MP0000604_amyloidosis1.68232775
43MP0002822_catalepsy1.67303495
44MP0003183_abnormal_peptide_metabolism1.60487151
45MP0002638_abnormal_pupillary_reflex1.57889453
46MP0001800_abnormal_humoral_immune1.57743430
47MP0002148_abnormal_hypersensitivity_rea1.57583255
48MP0002723_abnormal_immune_serum1.56642539
49MP0002420_abnormal_adaptive_immunity1.56068851
50MP0001958_emphysema1.55420504
51MP0001819_abnormal_immune_cell1.53959006
52MP0002234_abnormal_pharynx_morphology1.50802141
53MP0003075_altered_response_to1.49123213
54MP0006036_abnormal_mitochondrial_physio1.48026860
55MP0002452_abnormal_antigen_presenting1.45203821
56MP0005671_abnormal_response_to1.42318230
57MP0001984_abnormal_olfaction1.38971010
58MP0001545_abnormal_hematopoietic_system1.38217059
59MP0005397_hematopoietic_system_phenotyp1.38217059
60MP0004043_abnormal_pH_regulation1.37911015
61MP0004145_abnormal_muscle_electrophysio1.37789553
62MP0008961_abnormal_basal_metabolism1.36974424
63MP0003279_aneurysm1.36755129
64MP0002837_dystrophic_cardiac_calcinosis1.36471977
65MP0003828_pulmonary_edema1.35831856
66MP0010155_abnormal_intestine_physiology1.29810890
67MP0002998_abnormal_bone_remodeling1.29454648
68MP0002405_respiratory_system_inflammati1.29279252
69MP0004859_abnormal_synaptic_plasticity1.28023929
70MP0000678_abnormal_parathyroid_gland1.26578629
71MP0009333_abnormal_splenocyte_physiolog1.26171003
72MP0000343_altered_response_to1.22738477
73MP0001348_abnormal_lacrimal_gland1.19227316
74MP0000358_abnormal_cell_content/1.18710618
75MP0003763_abnormal_thymus_physiology1.16940434
76MP0004381_abnormal_hair_follicle1.16892349
77MP0006035_abnormal_mitochondrial_morpho1.15904080
78MP0002909_abnormal_adrenal_gland1.15164737
79MP0003453_abnormal_keratinocyte_physiol1.14632376
80MP0001845_abnormal_inflammatory_respons1.13233958
81MP0002398_abnormal_bone_marrow1.13163837
82MP0000858_altered_metastatic_potential1.12836409
83MP0001968_abnormal_touch/_nociception1.12427061
84MP0008058_abnormal_DNA_repair1.11829328
85MP0002132_abnormal_respiratory_system1.11607075
86MP0004233_abnormal_muscle_weight1.11482024
87MP0003866_abnormal_defecation1.11086136
88MP0005409_darkened_coat_color1.10395834
89MP0000716_abnormal_immune_system1.09938713
90MP0005310_abnormal_salivary_gland1.09814471
91MP0003690_abnormal_glial_cell1.09231314
92MP0002736_abnormal_nociception_after1.08637539
93MP0000013_abnormal_adipose_tissue1.06716924
94MP0005166_decreased_susceptibility_to1.06696301
95MP0001765_abnormal_ion_homeostasis1.04926178
96MP0008874_decreased_physiological_sensi1.03869325
97MP0008995_early_reproductive_senescence1.03538961
98MP0004185_abnormal_adipocyte_glucose1.03506185
99MP0008469_abnormal_protein_level1.02147612
100MP0002102_abnormal_ear_morphology1.01045107
101MP0003283_abnormal_digestive_organ1.00843150
102MP0000681_abnormal_thyroid_gland1.00711660
103MP0009764_decreased_sensitivity_to0.97612708
104MP0003045_fibrosis0.96791170
105MP0001663_abnormal_digestive_system0.96494812
106MP0004858_abnormal_nervous_system0.96215030
107MP0005390_skeleton_phenotype0.96062085
108MP0004133_heterotaxia0.95446913
109MP0002751_abnormal_autonomic_nervous0.94737831
110MP0002269_muscular_atrophy0.94058391
111MP0001851_eye_inflammation0.93753150
112MP0005636_abnormal_mineral_homeostasis0.93751725
113MP0002933_joint_inflammation0.93489886
114MP0008438_abnormal_cutaneous_collagen0.93311823
115MP0001270_distended_abdomen0.92408041
116MP0002429_abnormal_blood_cell0.91013393
117MP0000749_muscle_degeneration0.90664947
118MP0010030_abnormal_orbit_morphology0.90133236
119MP0006276_abnormal_autonomic_nervous0.89902372
120MP0003091_abnormal_cell_migration0.88457968
121MP0002722_abnormal_immune_system0.87899159
122MP0000015_abnormal_ear_pigmentation0.85861408
123MP0005666_abnormal_adipose_tissue0.85238992
124MP0001873_stomach_inflammation0.85165691
125MP0001849_ear_inflammation0.85162720
126MP0002971_abnormal_brown_adipose0.84130949
127MP0005377_hearing/vestibular/ear_phenot0.83748611
128MP0003878_abnormal_ear_physiology0.83748611
129MP0004036_abnormal_muscle_relaxation0.83397699
130MP0001986_abnormal_taste_sensitivity0.82912051
131MP0001542_abnormal_bone_strength0.82758100
132MP0005499_abnormal_olfactory_system0.82278276
133MP0005394_taste/olfaction_phenotype0.82278276
134MP0003119_abnormal_digestive_system0.82107812
135MP0000689_abnormal_spleen_morphology0.81379854
136MP0003315_abnormal_perineum_morphology0.81331325
137MP0003786_premature_aging0.79461772
138MP0005551_abnormal_eye_electrophysiolog0.79188814
139MP0004019_abnormal_vitamin_homeostasis0.78408343
140MP0008789_abnormal_olfactory_epithelium0.77223658
141MP0003111_abnormal_nucleus_morphology0.76431720
142MP0005076_abnormal_cell_differentiation0.76404121
143MP0002332_abnormal_exercise_endurance0.76238343
144MP0006292_abnormal_olfactory_placode0.76181152
145MP0003115_abnormal_respiratory_system0.73455611
146MP0005389_reproductive_system_phenotype0.72188573
147MP0000759_abnormal_skeletal_muscle0.71775020
148MP0005253_abnormal_eye_physiology0.70401770
149MP0000703_abnormal_thymus_morphology0.69690784
150MP0006072_abnormal_retinal_apoptosis0.69616357
151MP0003329_amyloid_beta_deposits0.69172563
152MP0008007_abnormal_cellular_replicative0.68848629
153MP0000767_abnormal_smooth_muscle0.67016445
154MP0000920_abnormal_myelination0.66917587
155MP0003795_abnormal_bone_structure0.66510479
156MP0002282_abnormal_trachea_morphology0.65743628
157MP0003137_abnormal_impulse_conducting0.64913364
158MP0008569_lethality_at_weaning0.64624064
159MP0004142_abnormal_muscle_tone0.64084839
160MP0004811_abnormal_neuron_physiology0.62925527
161MP0005375_adipose_tissue_phenotype0.61822834
162MP0009672_abnormal_birth_weight0.61733022
163MP0000750_abnormal_muscle_regeneration0.61236232
164MP0000534_abnormal_ureter_morphology0.60067179
165MP0000049_abnormal_middle_ear0.59279323
166MP0001944_abnormal_pancreas_morphology0.59237196
167MP0001764_abnormal_homeostasis0.57637881
168MP0000955_abnormal_spinal_cord0.57454487
169MP0002106_abnormal_muscle_physiology0.57296820
170MP0003942_abnormal_urinary_system0.56701365
171MP0005330_cardiomyopathy0.55855562
172MP0002127_abnormal_cardiovascular_syste0.55153268
173MP0005365_abnormal_bile_salt0.53715416
174MP0003879_abnormal_hair_cell0.53082640
175MP0002184_abnormal_innervation0.52504333
176MP0002277_abnormal_respiratory_mucosa0.51564670
177MP0003948_abnormal_gas_homeostasis0.50674781
178MP0002752_abnormal_somatic_nervous0.49695543
179MP0002557_abnormal_social/conspecific_i0.49120931
180MP0005319_abnormal_enzyme/_coenzyme0.48724087
181MP0003861_abnormal_nervous_system0.48718495
182MP0001756_abnormal_urination0.47504669
183MP0002152_abnormal_brain_morphology0.47019144
184MP0009840_abnormal_foam_cell0.46888766
185MP0010386_abnormal_urinary_bladder0.46584356
186MP0002249_abnormal_larynx_morphology0.46196668
187MP0001502_abnormal_circadian_rhythm0.45554163
188MP0002067_abnormal_sensory_capabilities0.44834173
189MP0002733_abnormal_thermal_nociception0.44777955
190MP0004087_abnormal_muscle_fiber0.44392294

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.73666176
2Abnormal respiratory epithelium morphology (HP:0012253)7.34741509
3Abnormal respiratory motile cilium morphology (HP:0005938)7.34741509
4Abnormal respiratory motile cilium physiology (HP:0012261)7.09235171
5Chronic bronchitis (HP:0004469)6.37444956
6Infertility (HP:0000789)5.84069588
7Rhinitis (HP:0012384)5.63208312
8Abnormal ciliary motility (HP:0012262)5.38632362
9Nasal polyposis (HP:0100582)5.31789995
10Hypochromic microcytic anemia (HP:0004840)4.94689354
11Abnormality of the nasal mucosa (HP:0000433)4.51613722
12Eczematoid dermatitis (HP:0000976)4.49349701
13Male infertility (HP:0003251)3.99752033
14Hypochromic anemia (HP:0001931)3.94927854
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.88037864
16Recurrent abscess formation (HP:0002722)3.62715159
17Abnormality of macrophages (HP:0004311)3.55954132
18Recurrent bacterial skin infections (HP:0005406)3.49593904
19Bronchiectasis (HP:0002110)3.34519027
20Myositis (HP:0100614)3.33943373
21Bronchitis (HP:0012387)3.28781132
22Gastrointestinal infarctions (HP:0005244)3.26868548
23Nephronophthisis (HP:0000090)3.26616741
24Microcytic anemia (HP:0001935)3.18051921
25Recurrent gram-negative bacterial infections (HP:0005420)3.07037213
26Impulsivity (HP:0100710)3.00890238
27Orchitis (HP:0100796)2.98340301
28Elevated erythrocyte sedimentation rate (HP:0003565)2.84923869
29Chronic obstructive pulmonary disease (HP:0006510)2.83502632
30Obstructive lung disease (HP:0006536)2.83502632
31Abnormality of liposaccharide metabolism (HP:0010968)2.83007886
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.83007886
33Abnormality of glycolipid metabolism (HP:0010969)2.83007886
34Obstructive sleep apnea (HP:0002870)2.82201831
35Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.79881701
36Cholecystitis (HP:0001082)2.76950731
37Abnormal gallbladder physiology (HP:0012438)2.76950731
38Cellulitis (HP:0100658)2.76734570
39Spontaneous hematomas (HP:0007420)2.73109654
40Polycythemia (HP:0001901)2.67684882
41Abnormal hemoglobin (HP:0011902)2.67627215
42Gingivitis (HP:0000230)2.66400580
43Abnormal spermatogenesis (HP:0008669)2.65101024
44Peritonitis (HP:0002586)2.64563734
45Increased IgE level (HP:0003212)2.56282912
46Myoglobinuria (HP:0002913)2.56102639
47Exercise-induced myalgia (HP:0003738)2.54295679
48Mediastinal lymphadenopathy (HP:0100721)2.54192565
49Dysostosis multiplex (HP:0000943)2.50953585
50Asymmetric septal hypertrophy (HP:0001670)2.48604125
51Prolonged bleeding time (HP:0003010)2.48163888
52Urticaria (HP:0001025)2.44869467
53Retrobulbar optic neuritis (HP:0100654)2.40879884
54Optic neuritis (HP:0100653)2.40879884
55Abnormality of the lower motor neuron (HP:0002366)2.40579844
56Abnormality of the renal medulla (HP:0100957)2.34931503
57Increased variability in muscle fiber diameter (HP:0003557)2.32468213
58Stomatitis (HP:0010280)2.32083860
59Purpura (HP:0000979)2.31845045
60Hyperacusis (HP:0010780)2.31481691
61Abnormality of cells of the erythroid lineage (HP:0012130)2.28300358
62Thin bony cortex (HP:0002753)2.27609893
63Difficulty climbing stairs (HP:0003551)2.26993143
64Failure to thrive in infancy (HP:0001531)2.25585379
65Cerebral inclusion bodies (HP:0100314)2.25228675
66Large eyes (HP:0001090)2.23203238
67Abnormal number of erythroid precursors (HP:0012131)2.22843666
68Slow saccadic eye movements (HP:0000514)2.22019593
69Meningitis (HP:0001287)2.20657327
70Increased cerebral lipofuscin (HP:0011813)2.20530944
71Visual hallucinations (HP:0002367)2.20340969
72Recurrent skin infections (HP:0001581)2.19502615
73Protrusio acetabuli (HP:0003179)2.17318757
74Recurrent fungal infections (HP:0002841)2.16664588
75Increased connective tissue (HP:0009025)2.16276125
76Petechiae (HP:0000967)2.09559205
77Hypertriglyceridemia (HP:0002155)2.09529211
78Myopathic facies (HP:0002058)2.09512336
79Recurrent otitis media (HP:0000403)2.08990601
80Abnormality of skeletal muscle fiber size (HP:0012084)2.06694386
81Epistaxis (HP:0000421)2.06685488
82Gastrointestinal inflammation (HP:0004386)2.06546442
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06461750
84Abnormality of polysaccharide metabolism (HP:0011012)2.06461750
85Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06461750
86Amyloidosis (HP:0011034)2.06270300
87Progressive muscle weakness (HP:0003323)2.05277272
88Bundle branch block (HP:0011710)2.04598489
89Increased serum ferritin (HP:0003281)2.04115567
90Rhabdomyolysis (HP:0003201)2.03898696
91Vertebral compression fractures (HP:0002953)2.03885815
92Diplopia (HP:0000651)2.01394755
93Abnormality of binocular vision (HP:0011514)2.01394755
94Absent/shortened dynein arms (HP:0200106)10.3560480
95Dynein arm defect of respiratory motile cilia (HP:0012255)10.3560480
96Global brain atrophy (HP:0002283)1.99025593
97Inflammation of the large intestine (HP:0002037)1.98633710
98Emphysema (HP:0002097)1.98380344
99Episodic fever (HP:0001954)1.97679947
100Distal lower limb muscle weakness (HP:0009053)1.97297411
101Pustule (HP:0200039)1.95507618
102Cholelithiasis (HP:0001081)1.94052837
103Vasculitis (HP:0002633)1.93549606
104Systemic lupus erythematosus (HP:0002725)1.93428997
105EMG: neuropathic changes (HP:0003445)1.93033278
106Recurrent sinusitis (HP:0011108)1.92316040
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91889905
108Segmental peripheral demyelination/remyelination (HP:0003481)1.91520524
109Annular pancreas (HP:0001734)1.91302169
110Cerebral aneurysm (HP:0004944)1.91086836
111Ventricular fibrillation (HP:0001663)1.89672975
112Double outlet right ventricle (HP:0001719)1.88976390
113Congenital malformation of the right heart (HP:0011723)1.88976390
114Abnormal delayed hypersensitivity skin test (HP:0002963)1.88506220
115Gonadotropin excess (HP:0000837)1.88176888
116Medial flaring of the eyebrow (HP:0010747)1.87445650
117Easy fatigability (HP:0003388)1.87234055
118Axonal loss (HP:0003447)1.86599418
119Urinary glycosaminoglycan excretion (HP:0003541)1.86061188
120Mucopolysacchariduria (HP:0008155)1.86061188
121Muscle fiber splitting (HP:0003555)1.85633451
122Renal dysplasia (HP:0000110)1.85023566
123Gingival bleeding (HP:0000225)1.84721239
124Increased neuronal autofluorescent lipopigment (HP:0002074)1.84628234
125Abnormality of the aortic arch (HP:0012303)1.83241963
126Type 1 muscle fiber predominance (HP:0003803)1.82657382
127Hemorrhage of the eye (HP:0011885)1.82609098
128Chest pain (HP:0100749)1.81948139
129Impaired proprioception (HP:0010831)1.80346106
130Abnormality of iron homeostasis (HP:0011031)1.79980384
131Achilles tendon contracture (HP:0001771)1.78945300
132Ketosis (HP:0001946)1.77612138
133Hypertensive crisis (HP:0100735)1.77243040
134Hypercortisolism (HP:0001578)1.77057160
135Colitis (HP:0002583)1.77023122
136Reticulocytosis (HP:0001923)1.74307920
137Molar tooth sign on MRI (HP:0002419)1.73336106
138Abnormality of midbrain morphology (HP:0002418)1.73336106
139Encephalitis (HP:0002383)1.73305117
140Retinal dysplasia (HP:0007973)1.73207264
141Bulbar palsy (HP:0001283)1.73183296
142Acne (HP:0001061)1.73178000
143Postural instability (HP:0002172)1.73054407
144Truncus arteriosus (HP:0001660)1.71643724
145Mesangial abnormality (HP:0001966)1.71626986
146Polygenic inheritance (HP:0010982)1.71000550
147Renovascular hypertension (HP:0100817)1.70248148
148Hand muscle atrophy (HP:0009130)1.70145722
149Degeneration of anterior horn cells (HP:0002398)1.69367592
150Abnormality of the anterior horn cell (HP:0006802)1.69367592
151Tubulointerstitial nephritis (HP:0001970)1.69209709
152Dyschromatopsia (HP:0007641)1.66796952
153Stage 5 chronic kidney disease (HP:0003774)1.66314665
154Polymicrogyria (HP:0002126)1.65173147
155Bony spicule pigmentary retinopathy (HP:0007737)1.63513661
156Azoospermia (HP:0000027)1.63025704
157Neurofibrillary tangles (HP:0002185)1.62918174
158Cerebellar dysplasia (HP:0007033)1.62829965
159Late onset (HP:0003584)1.62189620
160Insomnia (HP:0100785)1.61939255
161Unsteady gait (HP:0002317)1.61525487
162Type II lissencephaly (HP:0007260)1.58134766
163Hyperglycinemia (HP:0002154)1.57416429
164Delusions (HP:0000746)1.57376394
165Macrocytic anemia (HP:0001972)1.56776222
166Amyotrophic lateral sclerosis (HP:0007354)1.52955097
167Abnormality of renal excretion (HP:0011036)1.52299942
168Absent rod-and cone-mediated responses on ERG (HP:0007688)1.51988644
169Sudden death (HP:0001699)1.51888119
170Reticulocytopenia (HP:0001896)1.47293406
171Gout (HP:0001997)1.46829571
172Severe global developmental delay (HP:0011344)1.46792693
173Tubulointerstitial abnormality (HP:0001969)1.46706342
174Emotional lability (HP:0000712)1.44884497
175Supranuclear gaze palsy (HP:0000605)1.44719271
176Hyperkalemia (HP:0002153)1.44589820
177Decreased central vision (HP:0007663)1.44468706
178Distal upper limb amyotrophy (HP:0007149)1.43735273
179Upper limb amyotrophy (HP:0009129)1.43735273
180Neoplasm of the heart (HP:0100544)1.42729738
181Abnormal urine output (HP:0012590)1.41900457
182Myokymia (HP:0002411)1.41035966
183Hypercholesterolemia (HP:0003124)1.40161049
184Personality changes (HP:0000751)1.40150837
185Polydipsia (HP:0001959)1.39167744
186Abnormal drinking behavior (HP:0030082)1.39167744
187Elfin facies (HP:0004428)1.38498975
188Tubular atrophy (HP:0000092)1.37577036
189Difficulty running (HP:0009046)1.37272234
190Lissencephaly (HP:0001339)1.36772653
191Decreased electroretinogram (ERG) amplitude (HP:0000654)1.36464355
192Optic disc pallor (HP:0000543)1.34269221
193Polyuria (HP:0000103)1.28592009
194Oculomotor apraxia (HP:0000657)1.27741132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.86628856
2PDK45.86628856
3TESK15.32622903
4PRKD34.92453323
5ICK3.91315308
6TLK13.58996446
7PDK23.46986598
8CDK192.97259092
9MAP2K32.95473478
10PRPF4B2.88569334
11DYRK32.28753251
12MAP4K12.15535079
13BCKDK2.10294840
14PTK2B2.09971034
15WNK42.06889884
16GRK62.06344826
17TRIB31.99632535
18MAP3K31.88902023
19STK381.73668871
20TNK21.71966327
21BLK1.69817405
22LMTK21.68934041
23NEK21.68578961
24IRAK41.65285951
25SIK11.60772203
26PASK1.60119182
27RIPK11.50093577
28FES1.49014577
29DYRK1B1.47408981
30CSK1.45640179
31MARK21.45081109
32MAP3K101.44042107
33TESK21.38940069
34TBK11.36288802
35TYK21.34025825
36SMG11.31668920
37EPHB11.27964398
38IRAK11.27839956
39SIK21.25876260
40MAP3K131.25672786
41PINK11.23633314
42MAPK121.14299147
43RPS6KA41.04885285
44RPS6KA21.04338556
45HCK1.02366908
46IRAK31.02146786
47PHKG21.01928201
48PHKG11.01928201
49NME21.00794889
50ACVR1B0.99709797
51PTK60.99277443
52DAPK20.98662202
53IKBKE0.96999573
54JAK30.96933188
55MAP3K110.96508521
56BRAF0.96465979
57CDC42BPA0.96081213
58SYK0.95811226
59BTK0.94729944
60RPS6KC10.93226247
61RPS6KL10.93226247
62PNCK0.93111174
63EPHB20.93102365
64IRAK20.89741964
65BUB10.88767937
66SGK30.88343181
67DAPK30.87960731
68MAP2K20.83496733
69RPS6KA60.80547555
70STK390.80311389
71FGR0.79123967
72GRK50.77071930
73STK160.76480024
74PDK10.75147037
75MAP2K60.75072381
76TGFBR20.73350523
77STK110.73242860
78JAK20.72277953
79MAPK150.71007253
80MAP3K70.70462049
81ERN10.70099500
82MOS0.69768223
83PRKG20.66535021
84PRKCH0.64150844
85MAP3K60.63768062
86PDPK10.63341667
87PKN20.63063063
88BMX0.62993402
89DDR20.60019557
90KIT0.59753611
91MAP3K10.59274517
92SGK4940.58527512
93SGK2230.58527512
94CAMKK10.58279231
95IKBKB0.58149787
96LYN0.57887106
97AURKA0.56882850
98LRRK20.56492229
99ARAF0.55630417
100NME10.55032960
101JAK10.54776572
102MAPK70.53588227
103MAP2K40.50439963
104LCK0.50340162
105PAK10.50145551
106SGK20.49760725
107ILK0.48130777
108EPHA30.47180131
109MAPK40.46253324
110WNK30.46076967
111MAP3K20.45399586
112PRKD20.44412891
113MUSK0.43956590
114FYN0.43514180
115MARK30.43317239
116CDK11A0.43250989
117MAP3K140.42494495
118RET0.42430378
119PRKD10.41320257
120CSF1R0.41047722
121RPS6KA50.40459161
122RIPK40.39342674
123KSR20.39297673
124PRKCZ0.39107368
125MAPK110.38549663
126MAP3K90.37643905
127ITK0.37008087
128PAK60.36223188
129EEF2K0.35392484
130PRKCG0.34810987
131ABL20.32339560
132CHEK20.31710276
133CDK40.30147035
134CCNB10.28499811
135UHMK10.28351391
136WNK10.27117709
137PLK10.26985140
138TTK0.26001638
139TAOK20.25730242
140MTOR0.24834006
141CDK140.24334412
142BMPR1B0.24063390
143MARK10.24061159
144LATS20.23971689
145CDK150.23559605
146TAOK10.23459907
147NTRK10.20844886
148DYRK20.20738222
149CDK180.20243381
150STK38L0.19257613
151ZAP700.18877905
152NTRK20.17963669
153PRKAA10.15813551
154ATR0.14945293
155MAPKAPK30.14652560
156BRSK10.14644090
157CSNK2A10.14446944
158TGFBR10.14308667
159SRPK10.13938466
160TTN0.13901666
161HIPK20.13728661
162MAP2K70.13651309
163MAP2K10.13304864
164MAPKAPK50.13250788
165CAMK10.12681633
166CAMK2G0.12571803
167WEE10.12363665
168RPS6KA10.11799398

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.15157835
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.06618743
3Sulfur relay system_Homo sapiens_hsa041222.90437156
4Ribosome_Homo sapiens_hsa030102.62147052
5Selenocompound metabolism_Homo sapiens_hsa004502.49307542
6Cardiac muscle contraction_Homo sapiens_hsa042602.34381985
7Pyruvate metabolism_Homo sapiens_hsa006202.29149661
8Fructose and mannose metabolism_Homo sapiens_hsa000512.22829943
9Osteoclast differentiation_Homo sapiens_hsa043802.22090005
10Vitamin B6 metabolism_Homo sapiens_hsa007502.19915858
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.14141257
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.13786623
13Linoleic acid metabolism_Homo sapiens_hsa005912.13235882
14Propanoate metabolism_Homo sapiens_hsa006402.12019356
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.09364502
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04651135
17Malaria_Homo sapiens_hsa051441.88051475
18Leishmaniasis_Homo sapiens_hsa051401.88019649
19B cell receptor signaling pathway_Homo sapiens_hsa046621.85443548
20Other glycan degradation_Homo sapiens_hsa005111.84199258
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83673452
22Glucagon signaling pathway_Homo sapiens_hsa049221.83433727
23Huntingtons disease_Homo sapiens_hsa050161.82997296
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.71814120
25Fatty acid degradation_Homo sapiens_hsa000711.68445516
26Pentose phosphate pathway_Homo sapiens_hsa000301.67284808
27Carbon metabolism_Homo sapiens_hsa012001.64491845
28Acute myeloid leukemia_Homo sapiens_hsa052211.64118817
29Staphylococcus aureus infection_Homo sapiens_hsa051501.60428659
30Fatty acid biosynthesis_Homo sapiens_hsa000611.59380802
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53125282
32Tuberculosis_Homo sapiens_hsa051521.50528193
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50489650
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45370176
35Pyrimidine metabolism_Homo sapiens_hsa002401.43697796
36Parkinsons disease_Homo sapiens_hsa050121.43149295
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42066606
38Fat digestion and absorption_Homo sapiens_hsa049751.39370575
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37958858
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.33311724
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32649036
42Non-small cell lung cancer_Homo sapiens_hsa052231.30295278
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30277700
44DNA replication_Homo sapiens_hsa030301.29992724
45Oxidative phosphorylation_Homo sapiens_hsa001901.29699319
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.27723408
47Purine metabolism_Homo sapiens_hsa002301.26684203
48Glycerolipid metabolism_Homo sapiens_hsa005611.26040666
49Insulin secretion_Homo sapiens_hsa049111.25256223
50Base excision repair_Homo sapiens_hsa034101.23182775
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.22092119
52Basal transcription factors_Homo sapiens_hsa030221.21929858
53Allograft rejection_Homo sapiens_hsa053301.20847350
54Toxoplasmosis_Homo sapiens_hsa051451.18272632
55Chemokine signaling pathway_Homo sapiens_hsa040621.18090193
56Graft-versus-host disease_Homo sapiens_hsa053321.16857283
57Autoimmune thyroid disease_Homo sapiens_hsa053201.15532319
58Chronic myeloid leukemia_Homo sapiens_hsa052201.15054770
59PPAR signaling pathway_Homo sapiens_hsa033201.14884292
60Biosynthesis of amino acids_Homo sapiens_hsa012301.14136202
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14097403
62Notch signaling pathway_Homo sapiens_hsa043301.13847889
63Fanconi anemia pathway_Homo sapiens_hsa034601.12586999
64Neurotrophin signaling pathway_Homo sapiens_hsa047221.12103326
65African trypanosomiasis_Homo sapiens_hsa051431.12034193
66Oocyte meiosis_Homo sapiens_hsa041141.10682748
67Synaptic vesicle cycle_Homo sapiens_hsa047211.10008446
68Homologous recombination_Homo sapiens_hsa034401.08654699
69GnRH signaling pathway_Homo sapiens_hsa049121.07674044
70Lysosome_Homo sapiens_hsa041421.06541535
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05879746
72Amphetamine addiction_Homo sapiens_hsa050311.05611022
73Spliceosome_Homo sapiens_hsa030401.04194078
74T cell receptor signaling pathway_Homo sapiens_hsa046601.03332592
75Phospholipase D signaling pathway_Homo sapiens_hsa040721.03295221
76Endocytosis_Homo sapiens_hsa041441.02575372
77Pancreatic cancer_Homo sapiens_hsa052121.02121305
78Leukocyte transendothelial migration_Homo sapiens_hsa046701.01573544
79Galactose metabolism_Homo sapiens_hsa000521.01526150
80TNF signaling pathway_Homo sapiens_hsa046681.01079139
81Fatty acid metabolism_Homo sapiens_hsa012120.98359192
82Hepatitis C_Homo sapiens_hsa051600.98146445
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97726107
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.97655835
85RNA transport_Homo sapiens_hsa030130.96813277
86RNA polymerase_Homo sapiens_hsa030200.96803426
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95810100
88* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95721023
89mTOR signaling pathway_Homo sapiens_hsa041500.95162732
90Alzheimers disease_Homo sapiens_hsa050100.95152953
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95105289
92Phagosome_Homo sapiens_hsa041450.93693153
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.91905831
94Influenza A_Homo sapiens_hsa051640.90928835
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89568793
96Platelet activation_Homo sapiens_hsa046110.89139629
97Proteasome_Homo sapiens_hsa030500.87005073
98Prion diseases_Homo sapiens_hsa050200.86166234
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.85028242
100Prolactin signaling pathway_Homo sapiens_hsa049170.83064334
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82924312
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82659945
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82456842
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.82317512
105Hematopoietic cell lineage_Homo sapiens_hsa046400.81322204
106Renal cell carcinoma_Homo sapiens_hsa052110.81191635
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81156813
108Amoebiasis_Homo sapiens_hsa051460.80931112
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80535925
110MAPK signaling pathway_Homo sapiens_hsa040100.80217281
111Viral myocarditis_Homo sapiens_hsa054160.80053588
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.79587063
113Systemic lupus erythematosus_Homo sapiens_hsa053220.79466984
114Bladder cancer_Homo sapiens_hsa052190.78773267
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78665693
116Glioma_Homo sapiens_hsa052140.78557044
117Alcoholism_Homo sapiens_hsa050340.78440206
118Pertussis_Homo sapiens_hsa051330.77666365
119Mineral absorption_Homo sapiens_hsa049780.77473549
120VEGF signaling pathway_Homo sapiens_hsa043700.76394001
121Measles_Homo sapiens_hsa051620.75895056
122Salmonella infection_Homo sapiens_hsa051320.75147506
123Arachidonic acid metabolism_Homo sapiens_hsa005900.73927644
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73715468
125Endometrial cancer_Homo sapiens_hsa052130.72720342
126Choline metabolism in cancer_Homo sapiens_hsa052310.71454865
127Insulin resistance_Homo sapiens_hsa049310.70178176
128Inositol phosphate metabolism_Homo sapiens_hsa005620.69950518
129Glutathione metabolism_Homo sapiens_hsa004800.69920164
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68441750
131Type I diabetes mellitus_Homo sapiens_hsa049400.68279964
132Apoptosis_Homo sapiens_hsa042100.67964641
133mRNA surveillance pathway_Homo sapiens_hsa030150.67724819
134Hepatitis B_Homo sapiens_hsa051610.66969875
135Primary immunodeficiency_Homo sapiens_hsa053400.66969704
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65854744
137Cholinergic synapse_Homo sapiens_hsa047250.65770553
138ErbB signaling pathway_Homo sapiens_hsa040120.65026240
139Gastric acid secretion_Homo sapiens_hsa049710.64309084
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64271864
141FoxO signaling pathway_Homo sapiens_hsa040680.62725604
142Hedgehog signaling pathway_Homo sapiens_hsa043400.62482662
143Rap1 signaling pathway_Homo sapiens_hsa040150.60702198
144Intestinal immune network for IgA production_Homo sapiens_hsa046720.60094872
145Antigen processing and presentation_Homo sapiens_hsa046120.59004906
146Metabolic pathways_Homo sapiens_hsa011000.58560769
147Bile secretion_Homo sapiens_hsa049760.58217350
148Oxytocin signaling pathway_Homo sapiens_hsa049210.57636972
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57341879
150AMPK signaling pathway_Homo sapiens_hsa041520.57286197
151Rheumatoid arthritis_Homo sapiens_hsa053230.56105159
152Insulin signaling pathway_Homo sapiens_hsa049100.55658284
153Nucleotide excision repair_Homo sapiens_hsa034200.53608809
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53391991
155Renin secretion_Homo sapiens_hsa049240.53038162
156Mismatch repair_Homo sapiens_hsa034300.51686260
157Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50582363
158Folate biosynthesis_Homo sapiens_hsa007900.49121455
159Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47797481
160Estrogen signaling pathway_Homo sapiens_hsa049150.46378858
161Cocaine addiction_Homo sapiens_hsa050300.45402457
162Adipocytokine signaling pathway_Homo sapiens_hsa049200.44751084
163cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41840957
164Dorso-ventral axis formation_Homo sapiens_hsa043200.38820209
165Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36701728
166Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34231466
167Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33047562
168Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32110172
169Thyroid hormone synthesis_Homo sapiens_hsa049180.31913304
170Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31692727
171Pancreatic secretion_Homo sapiens_hsa049720.31192538
172Calcium signaling pathway_Homo sapiens_hsa040200.31052546
173ABC transporters_Homo sapiens_hsa020100.29963010
174Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29332354
175Starch and sucrose metabolism_Homo sapiens_hsa005000.27713157
176Type II diabetes mellitus_Homo sapiens_hsa049300.27155615
177Vascular smooth muscle contraction_Homo sapiens_hsa042700.26039961
178Long-term potentiation_Homo sapiens_hsa047200.26029103
179Chemical carcinogenesis_Homo sapiens_hsa052040.25958716
180Peroxisome_Homo sapiens_hsa041460.25091004

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