

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 5.56394935 |
| 2 | mitotic sister chromatid cohesion (GO:0007064) | 5.49724940 |
| 3 | nuclear pore organization (GO:0006999) | 5.15166737 |
| 4 | pre-miRNA processing (GO:0031054) | 4.92615871 |
| 5 | regulation of RNA export from nucleus (GO:0046831) | 4.57992200 |
| 6 | negative regulation of histone methylation (GO:0031061) | 4.28127766 |
| 7 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.09848348 |
| 8 | pore complex assembly (GO:0046931) | 3.99648938 |
| 9 | regulation of histone H3-K9 methylation (GO:0051570) | 3.99381259 |
| 10 | regulation of sister chromatid cohesion (GO:0007063) | 3.90057722 |
| 11 | cytoplasmic mRNA processing body assembly (GO:0033962) | 3.89724926 |
| 12 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.70410477 |
| 13 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.70410477 |
| 14 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.70410477 |
| 15 | regulation of nucleobase-containing compound transport (GO:0032239) | 3.69312928 |
| 16 | sister chromatid segregation (GO:0000819) | 3.64850763 |
| 17 | negative regulation of DNA repair (GO:0045738) | 3.64699749 |
| 18 | paraxial mesoderm development (GO:0048339) | 3.63257755 |
| 19 | dosage compensation (GO:0007549) | 3.61251798 |
| 20 | establishment of nucleus localization (GO:0040023) | 3.59041408 |
| 21 | glucocorticoid receptor signaling pathway (GO:0042921) | 3.59027421 |
| 22 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.57811502 |
| 23 | regulation of DNA endoreduplication (GO:0032875) | 3.57639136 |
| 24 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 3.55264182 |
| 25 | NLS-bearing protein import into nucleus (GO:0006607) | 3.53818476 |
| 26 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 3.44850469 |
| 27 | regulation of translation, ncRNA-mediated (GO:0045974) | 3.44850469 |
| 28 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 3.44850469 |
| 29 | histone H3-K4 trimethylation (GO:0080182) | 3.39553750 |
| 30 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.37157733 |
| 31 | histone H3-K9 demethylation (GO:0033169) | 3.34604625 |
| 32 | hippo signaling (GO:0035329) | 3.30617221 |
| 33 | protein localization to kinetochore (GO:0034501) | 3.25812639 |
| 34 | peptidyl-lysine trimethylation (GO:0018023) | 3.24214529 |
| 35 | histone H2A monoubiquitination (GO:0035518) | 3.23920276 |
| 36 | histone lysine demethylation (GO:0070076) | 3.23756216 |
| 37 | neural tube formation (GO:0001841) | 3.19942240 |
| 38 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.19699270 |
| 39 | V(D)J recombination (GO:0033151) | 3.17851205 |
| 40 | regulation of protein polyubiquitination (GO:1902914) | 3.13507948 |
| 41 | mitotic chromosome condensation (GO:0007076) | 3.11318595 |
| 42 | histone demethylation (GO:0016577) | 3.10857078 |
| 43 | positive regulation of chromosome segregation (GO:0051984) | 3.08524519 |
| 44 | DNA unwinding involved in DNA replication (GO:0006268) | 3.07227292 |
| 45 | presynaptic membrane assembly (GO:0097105) | 3.06111379 |
| 46 | histone H3-K36 demethylation (GO:0070544) | 3.05879541 |
| 47 | regulation of centriole replication (GO:0046599) | 3.04339967 |
| 48 | DNA duplex unwinding (GO:0032508) | 3.02804353 |
| 49 | mitotic nuclear envelope disassembly (GO:0007077) | 3.01690037 |
| 50 | DNA geometric change (GO:0032392) | 3.01455898 |
| 51 | peptidyl-lysine dimethylation (GO:0018027) | 3.01445604 |
| 52 | chromatin assembly (GO:0031497) | 3.01177388 |
| 53 | corticosteroid receptor signaling pathway (GO:0031958) | 2.98553863 |
| 54 | nuclear envelope disassembly (GO:0051081) | 2.97808403 |
| 55 | membrane disassembly (GO:0030397) | 2.97808403 |
| 56 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.96251532 |
| 57 | stress granule assembly (GO:0034063) | 2.95964321 |
| 58 | histone H3-K9 modification (GO:0061647) | 2.95766187 |
| 59 | protein dealkylation (GO:0008214) | 2.95487356 |
| 60 | protein demethylation (GO:0006482) | 2.95487356 |
| 61 | histone mRNA catabolic process (GO:0071044) | 2.95087231 |
| 62 | sister chromatid cohesion (GO:0007062) | 2.92616754 |
| 63 | protein-DNA complex disassembly (GO:0032986) | 2.90536686 |
| 64 | nucleosome disassembly (GO:0006337) | 2.90536686 |
| 65 | gene silencing by RNA (GO:0031047) | 2.88855774 |
| 66 | regulation of spindle organization (GO:0090224) | 2.87089814 |
| 67 | regulation of growth hormone secretion (GO:0060123) | 2.85387510 |
| 68 | negative regulation of histone modification (GO:0031057) | 2.81701465 |
| 69 | nucleus localization (GO:0051647) | 2.81295118 |
| 70 | histone lysine methylation (GO:0034968) | 2.79851514 |
| 71 | mRNA stabilization (GO:0048255) | 2.79355942 |
| 72 | RNA stabilization (GO:0043489) | 2.79355942 |
| 73 | protein localization to chromosome, centromeric region (GO:0071459) | 2.79228024 |
| 74 | interkinetic nuclear migration (GO:0022027) | 2.77743264 |
| 75 | positive regulation of developmental pigmentation (GO:0048087) | 2.77716076 |
| 76 | peptidyl-lysine methylation (GO:0018022) | 2.77397473 |
| 77 | positive regulation of cell cycle checkpoint (GO:1901978) | 2.77235782 |
| 78 | mitotic sister chromatid segregation (GO:0000070) | 2.75177949 |
| 79 | regulation of mitotic spindle organization (GO:0060236) | 2.75039166 |
| 80 | embryonic process involved in female pregnancy (GO:0060136) | 2.74880182 |
| 81 | positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145) | 2.72863401 |
| 82 | mRNA splice site selection (GO:0006376) | 2.71764799 |
| 83 | regulation of helicase activity (GO:0051095) | 2.71121328 |
| 84 | negative regulation of chromatin modification (GO:1903309) | 2.70906728 |
| 85 | presynaptic membrane organization (GO:0097090) | 2.70209392 |
| 86 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.69849737 |
| 87 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.69849737 |
| 88 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 2.68112629 |
| 89 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.67879899 |
| 90 | olfactory bulb development (GO:0021772) | 2.67789243 |
| 91 | regulation of intracellular estrogen receptor signaling pathway (GO:0033146) | 2.66416616 |
| 92 | protein localization to chromosome (GO:0034502) | 2.63861286 |
| 93 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.63453400 |
| 94 | translesion synthesis (GO:0019985) | 2.63280892 |
| 95 | gastrulation with mouth forming second (GO:0001702) | 2.62586206 |
| 96 | microtubule anchoring (GO:0034453) | 2.62242568 |
| 97 | regulation of histone methylation (GO:0031060) | 2.62177595 |
| 98 | dorsal/ventral axis specification (GO:0009950) | 2.61796022 |
| 99 | negative regulation of neurotransmitter secretion (GO:0046929) | 2.61507266 |
| 100 | intra-S DNA damage checkpoint (GO:0031573) | 2.61363311 |
| 101 | DNA topological change (GO:0006265) | 2.58407568 |
| 102 | negative regulation of DNA recombination (GO:0045910) | 2.58122800 |
| 103 | microtubule depolymerization (GO:0007019) | 2.57613126 |
| 104 | regulation of chromosome segregation (GO:0051983) | 2.57346652 |
| 105 | microtubule cytoskeleton organization involved in mitosis (GO:1902850) | 2.57299889 |
| 106 | neuronal stem cell maintenance (GO:0097150) | 2.56102901 |
| 107 | kinetochore organization (GO:0051383) | 2.54993343 |
| 108 | regulation of DNA damage checkpoint (GO:2000001) | 2.54716276 |
| 109 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.54484172 |
| 110 | gene silencing (GO:0016458) | 2.53784237 |
| 111 | chromatin assembly or disassembly (GO:0006333) | 2.53067226 |
| 112 | positive regulation of gene expression, epigenetic (GO:0045815) | 2.52235448 |
| 113 | regulation of gene silencing by RNA (GO:0060966) | 2.51539612 |
| 114 | regulation of posttranscriptional gene silencing (GO:0060147) | 2.51539612 |
| 115 | regulation of gene silencing by miRNA (GO:0060964) | 2.51539612 |
| 116 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.50912397 |
| 117 | negative regulation of fibroblast apoptotic process (GO:2000270) | 2.50604835 |
| 118 | genitalia morphogenesis (GO:0035112) | 2.49494685 |
| 119 | embryonic camera-type eye morphogenesis (GO:0048596) | 2.49359063 |
| 120 | regulation of centrosome duplication (GO:0010824) | 2.47883278 |
| 121 | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | 2.47277283 |
| 122 | spindle assembly involved in mitosis (GO:0090307) | 2.47219396 |
| 123 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.46575436 |
| 124 | morphogenesis of an epithelial sheet (GO:0002011) | 2.46009057 |
| 125 | histone H3-K4 methylation (GO:0051568) | 2.45547280 |
| 126 | histone H3-K9 methylation (GO:0051567) | 2.44797449 |
| 127 | ATP-dependent chromatin remodeling (GO:0043044) | 2.44039436 |
| 128 | heterochromatin organization (GO:0070828) | 2.43833490 |
| 129 | regulation of centrosome cycle (GO:0046605) | 2.42222879 |
| 130 | regulation of mRNA stability (GO:0043488) | 2.41894675 |
| 131 | histone methylation (GO:0016571) | 2.40443419 |
| 132 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.40344912 |
| 133 | histone H4-K16 acetylation (GO:0043984) | 2.39629053 |
| 134 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.38545511 |
| 135 | regulation of sister chromatid segregation (GO:0033045) | 2.38545511 |
| 136 | appendage development (GO:0048736) | 2.38526764 |
| 137 | limb development (GO:0060173) | 2.38526764 |
| 138 | regulation of chromatin silencing (GO:0031935) | 2.38095621 |
| 139 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.37191722 |
| 140 | regulation of histone H3-K27 methylation (GO:0061085) | 2.34654598 |
| 141 | peptidyl-threonine phosphorylation (GO:0018107) | 2.33167434 |
| 142 | regulation of pigment cell differentiation (GO:0050932) | 2.32892937 |
| 143 | establishment of spindle orientation (GO:0051294) | 2.32592425 |
| 144 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.31897112 |
| 145 | regulation of transforming growth factor beta2 production (GO:0032909) | 2.30896217 |
| 146 | nucleobase catabolic process (GO:0046113) | 2.30232689 |
| 147 | protein K48-linked deubiquitination (GO:0071108) | 2.26183459 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.78229472 |
| 2 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 6.02522279 |
| 3 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.44557900 |
| 4 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 4.92021499 |
| 5 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 4.53644442 |
| 6 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.58842071 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.44305769 |
| 8 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 3.42928377 |
| 9 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 3.23810388 |
| 10 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.21649779 |
| 11 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.98979060 |
| 12 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.37749818 |
| 13 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.37505881 |
| 14 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 2.35895935 |
| 15 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 2.32270236 |
| 16 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 2.17604891 |
| 17 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.17335137 |
| 18 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.16591880 |
| 19 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.15972202 |
| 20 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.12651324 |
| 21 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.11448629 |
| 22 | MYC_22102868_ChIP-Seq_BL_Human | 2.03136594 |
| 23 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.01647984 |
| 24 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.98535451 |
| 25 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.91797207 |
| 26 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.91602967 |
| 27 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.91451299 |
| 28 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.81733619 |
| 29 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.74974660 |
| 30 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.74969444 |
| 31 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.73369844 |
| 32 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.71832660 |
| 33 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.69837786 |
| 34 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.69024096 |
| 35 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.66860009 |
| 36 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.64221303 |
| 37 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.61471793 |
| 38 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.60530726 |
| 39 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.60530726 |
| 40 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.53998919 |
| 41 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.51722068 |
| 42 | STAT3_23295773_ChIP-Seq_U87_Human | 1.49601385 |
| 43 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.49382217 |
| 44 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.46833540 |
| 45 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.44776741 |
| 46 | P300_19829295_ChIP-Seq_ESCs_Human | 1.44373799 |
| 47 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.42889291 |
| 48 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.40774350 |
| 49 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.40661280 |
| 50 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.37879902 |
| 51 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.35450648 |
| 52 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.33552331 |
| 53 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.32748871 |
| 54 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.32237505 |
| 55 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.32176824 |
| 56 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.29243514 |
| 57 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.29240585 |
| 58 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.26247432 |
| 59 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.26090581 |
| 60 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.26053710 |
| 61 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.25739896 |
| 62 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.25688335 |
| 63 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.25062933 |
| 64 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.24549696 |
| 65 | TCF4_23295773_ChIP-Seq_U87_Human | 1.24495336 |
| 66 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.22599049 |
| 67 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.22429383 |
| 68 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.20617931 |
| 69 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.19388782 |
| 70 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.19178516 |
| 71 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.18960373 |
| 72 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.16386052 |
| 73 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 1.15853953 |
| 74 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 1.15473286 |
| 75 | CHD1_26751641_Chip-Seq_LNCaP_Human | 1.15467409 |
| 76 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 1.15397020 |
| 77 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.15072587 |
| 78 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.14084756 |
| 79 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.13926979 |
| 80 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 1.13373719 |
| 81 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.12001861 |
| 82 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.11703303 |
| 83 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.09601048 |
| 84 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.09407718 |
| 85 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.08571429 |
| 86 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.08178150 |
| 87 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.07857944 |
| 88 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.06644385 |
| 89 | GF1B_26923725_Chip-Seq_HPCs_Mouse | 1.05800664 |
| 90 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.05758449 |
| 91 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.05633995 |
| 92 | * ER_23166858_ChIP-Seq_MCF-7_Human | 1.05390879 |
| 93 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.05174374 |
| 94 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.04566514 |
| 95 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.02952521 |
| 96 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.01372412 |
| 97 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.01292730 |
| 98 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.00906688 |
| 99 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.00010513 |
| 100 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.99839352 |
| 101 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99825740 |
| 102 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.99803687 |
| 103 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.99085134 |
| 104 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.98938164 |
| 105 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.98699222 |
| 106 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.98224623 |
| 107 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.97672600 |
| 108 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.97536249 |
| 109 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.97223926 |
| 110 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.96480732 |
| 111 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.96277324 |
| 112 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.95965988 |
| 113 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.95802564 |
| 114 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.95775715 |
| 115 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.95535385 |
| 116 | TP53_16413492_ChIP-PET_HCT116_Human | 0.95490448 |
| 117 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.95490228 |
| 118 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.95239104 |
| 119 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.94985713 |
| 120 | TCF3_18347094_ChIP-ChIP_MESCs_Mouse | 0.94121755 |
| 121 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.93702618 |
| 122 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.93222098 |
| 123 | * RUNX2_22187159_ChIP-Seq_PCA_Human | 0.92487393 |
| 124 | EWS_26573619_Chip-Seq_HEK293_Human | 0.91914337 |
| 125 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 0.91469339 |
| 126 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.91037372 |
| 127 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.91037372 |
| 128 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.90900082 |
| 129 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.90669718 |
| 130 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.88802009 |
| 131 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 0.86771640 |
| 132 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.85832207 |
| 133 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.85064637 |
| 134 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.84721496 |
| 135 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.83833303 |
| 136 | FUS_26573619_Chip-Seq_HEK293_Human | 0.83785306 |
| 137 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.83574285 |
| 138 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.82970218 |
| 139 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.81930445 |
| 140 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.81930445 |
| 141 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.81930445 |
| 142 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.79954470 |
| 143 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.78441659 |
| 144 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.78157840 |
| 145 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.77108879 |
| 146 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.75970132 |
| 147 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.75517860 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000569_abnormal_digit_pigmentation | 3.45825061 |
| 2 | MP0005076_abnormal_cell_differentiation | 2.95205701 |
| 3 | MP0003121_genomic_imprinting | 2.91953129 |
| 4 | MP0003705_abnormal_hypodermis_morpholog | 2.82520102 |
| 5 | MP0010352_gastrointestinal_tract_polyps | 2.59783712 |
| 6 | MP0010307_abnormal_tumor_latency | 2.58315470 |
| 7 | MP0010094_abnormal_chromosome_stability | 2.55624589 |
| 8 | MP0003890_abnormal_embryonic-extraembry | 2.46299097 |
| 9 | MP0000778_abnormal_nervous_system | 2.36994655 |
| 10 | MP0003787_abnormal_imprinting | 2.28956797 |
| 11 | MP0003111_abnormal_nucleus_morphology | 2.25633993 |
| 12 | MP0003123_paternal_imprinting | 2.24467720 |
| 13 | MP0008057_abnormal_DNA_replication | 2.17085380 |
| 14 | MP0003077_abnormal_cell_cycle | 2.13533763 |
| 15 | MP0010030_abnormal_orbit_morphology | 2.12296110 |
| 16 | MP0010234_abnormal_vibrissa_follicle | 2.11765236 |
| 17 | MP0006292_abnormal_olfactory_placode | 2.09364089 |
| 18 | MP0000537_abnormal_urethra_morphology | 2.09195702 |
| 19 | MP0004197_abnormal_fetal_growth/weight/ | 2.04062836 |
| 20 | MP0002084_abnormal_developmental_patter | 1.91327683 |
| 21 | MP0005248_abnormal_Harderian_gland | 1.88835384 |
| 22 | MP0001293_anophthalmia | 1.87862097 |
| 23 | MP0009053_abnormal_anal_canal | 1.87277067 |
| 24 | MP0003122_maternal_imprinting | 1.85075490 |
| 25 | MP0005187_abnormal_penis_morphology | 1.82277817 |
| 26 | MP0008007_abnormal_cellular_replicative | 1.75060535 |
| 27 | MP0000350_abnormal_cell_proliferation | 1.73966770 |
| 28 | MP0001672_abnormal_embryogenesis/_devel | 1.71836449 |
| 29 | MP0005380_embryogenesis_phenotype | 1.71836449 |
| 30 | MP0002086_abnormal_extraembryonic_tissu | 1.70487892 |
| 31 | MP0002088_abnormal_embryonic_growth/wei | 1.66728425 |
| 32 | MP0003984_embryonic_growth_retardation | 1.66480757 |
| 33 | MP0002085_abnormal_embryonic_tissue | 1.65996348 |
| 34 | MP0009703_decreased_birth_body | 1.65918198 |
| 35 | MP0003937_abnormal_limbs/digits/tail_de | 1.65083633 |
| 36 | MP0001730_embryonic_growth_arrest | 1.62775861 |
| 37 | MP0002009_preneoplasia | 1.61625831 |
| 38 | MP0008877_abnormal_DNA_methylation | 1.58171684 |
| 39 | MP0000428_abnormal_craniofacial_morphol | 1.56562302 |
| 40 | MP0003935_abnormal_craniofacial_develop | 1.55905737 |
| 41 | MP0000733_abnormal_muscle_development | 1.52932679 |
| 42 | MP0001697_abnormal_embryo_size | 1.52525546 |
| 43 | MP0004808_abnormal_hematopoietic_stem | 1.51186676 |
| 44 | MP0002877_abnormal_melanocyte_morpholog | 1.47618967 |
| 45 | MP0002092_abnormal_eye_morphology | 1.46217963 |
| 46 | MP0004957_abnormal_blastocyst_morpholog | 1.44691917 |
| 47 | MP0001849_ear_inflammation | 1.43316931 |
| 48 | MP0004264_abnormal_extraembryonic_tissu | 1.43226852 |
| 49 | MP0003567_abnormal_fetal_cardiomyocyte | 1.43035380 |
| 50 | MP0003221_abnormal_cardiomyocyte_apopto | 1.38535821 |
| 51 | MP0005499_abnormal_olfactory_system | 1.33197479 |
| 52 | MP0005394_taste/olfaction_phenotype | 1.33197479 |
| 53 | MP0003115_abnormal_respiratory_system | 1.31527462 |
| 54 | MP0000631_abnormal_neuroendocrine_gland | 1.30112440 |
| 55 | MP0006054_spinal_hemorrhage | 1.29827815 |
| 56 | MP0002697_abnormal_eye_size | 1.29519703 |
| 57 | MP0001299_abnormal_eye_distance/ | 1.28611185 |
| 58 | MP0009672_abnormal_birth_weight | 1.28203245 |
| 59 | MP0005409_darkened_coat_color | 1.27536191 |
| 60 | MP0001177_atelectasis | 1.25302897 |
| 61 | MP0001286_abnormal_eye_development | 1.25015121 |
| 62 | MP0000955_abnormal_spinal_cord | 1.24097271 |
| 63 | MP0003300_gastrointestinal_ulcer | 1.23570432 |
| 64 | MP0008058_abnormal_DNA_repair | 1.23146675 |
| 65 | MP0000432_abnormal_head_morphology | 1.21267329 |
| 66 | MP0002925_abnormal_cardiovascular_devel | 1.21210293 |
| 67 | MP0004233_abnormal_muscle_weight | 1.20086291 |
| 68 | MP0002653_abnormal_ependyma_morphology | 1.17671456 |
| 69 | MP0003119_abnormal_digestive_system | 1.16606696 |
| 70 | MP0002152_abnormal_brain_morphology | 1.16175400 |
| 71 | MP0005423_abnormal_somatic_nervous | 1.15853782 |
| 72 | MP0002080_prenatal_lethality | 1.15701011 |
| 73 | MP0001188_hyperpigmentation | 1.14358618 |
| 74 | MP0009697_abnormal_copulation | 1.12713884 |
| 75 | MP0003385_abnormal_body_wall | 1.12278476 |
| 76 | MP0008995_early_reproductive_senescence | 1.12263978 |
| 77 | MP0001915_intracranial_hemorrhage | 1.11622522 |
| 78 | MP0010678_abnormal_skin_adnexa | 1.10994067 |
| 79 | MP0002396_abnormal_hematopoietic_system | 1.10342736 |
| 80 | MP0005623_abnormal_meninges_morphology | 1.08789294 |
| 81 | MP0003861_abnormal_nervous_system | 1.07851754 |
| 82 | MP0000516_abnormal_urinary_system | 1.07753080 |
| 83 | MP0005367_renal/urinary_system_phenotyp | 1.07753080 |
| 84 | MP0003566_abnormal_cell_adhesion | 1.05089538 |
| 85 | MP0003942_abnormal_urinary_system | 1.03940256 |
| 86 | MP0003755_abnormal_palate_morphology | 1.03686529 |
| 87 | MP0003693_abnormal_embryo_hatching | 1.02489506 |
| 88 | MP0002938_white_spotting | 1.01645862 |
| 89 | MP0002932_abnormal_joint_morphology | 1.00987188 |
| 90 | MP0005645_abnormal_hypothalamus_physiol | 1.00595573 |
| 91 | MP0003091_abnormal_cell_migration | 1.00200455 |
| 92 | MP0005503_abnormal_tendon_morphology | 0.99291551 |
| 93 | MP0004811_abnormal_neuron_physiology | 0.98997380 |
| 94 | MP0002233_abnormal_nose_morphology | 0.97795027 |
| 95 | MP0002751_abnormal_autonomic_nervous | 0.94439970 |
| 96 | MP0003941_abnormal_skin_development | 0.93911549 |
| 97 | MP0002111_abnormal_tail_morphology | 0.93644188 |
| 98 | MP0002166_altered_tumor_susceptibility | 0.91813068 |
| 99 | MP0002116_abnormal_craniofacial_bone | 0.91455267 |
| 100 | MP0000566_synostosis | 0.89888644 |
| 101 | MP0000534_abnormal_ureter_morphology | 0.89061373 |
| 102 | MP0002928_abnormal_bile_duct | 0.88568341 |
| 103 | MP0000647_abnormal_sebaceous_gland | 0.87839328 |
| 104 | MP0002249_abnormal_larynx_morphology | 0.87657804 |
| 105 | MP0005391_vision/eye_phenotype | 0.87427862 |
| 106 | MP0003943_abnormal_hepatobiliary_system | 0.87246650 |
| 107 | MP0002184_abnormal_innervation | 0.86894869 |
| 108 | MP0002109_abnormal_limb_morphology | 0.85318514 |
| 109 | MP0000703_abnormal_thymus_morphology | 0.84383416 |
| 110 | MP0000383_abnormal_hair_follicle | 0.84056531 |
| 111 | MP0009780_abnormal_chondrocyte_physiolo | 0.83686204 |
| 112 | MP0009384_cardiac_valve_regurgitation | 0.82118626 |
| 113 | MP0002282_abnormal_trachea_morphology | 0.81850226 |
| 114 | MP0000049_abnormal_middle_ear | 0.81684391 |
| 115 | MP0000427_abnormal_hair_cycle | 0.81246908 |
| 116 | MP0003283_abnormal_digestive_organ | 0.79832236 |
| 117 | MP0004185_abnormal_adipocyte_glucose | 0.77658086 |
| 118 | MP0000266_abnormal_heart_morphology | 0.77488284 |
| 119 | MP0003938_abnormal_ear_development | 0.77317625 |
| 120 | MP0002114_abnormal_axial_skeleton | 0.77009517 |
| 121 | MP0008932_abnormal_embryonic_tissue | 0.76522618 |
| 122 | MP0004272_abnormal_basement_membrane | 0.75374820 |
| 123 | MP0002177_abnormal_outer_ear | 0.74632697 |
| 124 | MP0002102_abnormal_ear_morphology | 0.74562484 |
| 125 | MP0002081_perinatal_lethality | 0.74367143 |
| 126 | MP0001943_abnormal_respiration | 0.73699816 |
| 127 | MP0002882_abnormal_neuron_morphology | 0.72044947 |
| 128 | MP0002006_tumorigenesis | 0.70746024 |
| 129 | MP0003880_abnormal_central_pattern | 0.69408082 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Short 4th metacarpal (HP:0010044) | 4.01328359 |
| 2 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 4.01328359 |
| 3 | Volvulus (HP:0002580) | 3.96229716 |
| 4 | Abnormality of the fingertips (HP:0001211) | 3.01565689 |
| 5 | Abnormality of the 4th metacarpal (HP:0010012) | 2.94200608 |
| 6 | Abnormality of the astrocytes (HP:0100707) | 2.89382747 |
| 7 | Astrocytoma (HP:0009592) | 2.89382747 |
| 8 | Macroorchidism (HP:0000053) | 2.87952741 |
| 9 | Heterotopia (HP:0002282) | 2.83976884 |
| 10 | Ependymoma (HP:0002888) | 2.77192939 |
| 11 | Increased nuchal translucency (HP:0010880) | 2.70279361 |
| 12 | Papillary thyroid carcinoma (HP:0002895) | 2.48656951 |
| 13 | Glioma (HP:0009733) | 2.48638458 |
| 14 | Curly hair (HP:0002212) | 2.45658576 |
| 15 | Drooling (HP:0002307) | 2.44763850 |
| 16 | Narrow palate (HP:0000189) | 2.43611227 |
| 17 | Abnormality of the labia minora (HP:0012880) | 2.42522314 |
| 18 | Long eyelashes (HP:0000527) | 2.42355135 |
| 19 | Embryonal renal neoplasm (HP:0011794) | 2.41419644 |
| 20 | Medulloblastoma (HP:0002885) | 2.41325228 |
| 21 | Chronic hepatic failure (HP:0100626) | 2.38201052 |
| 22 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.37475884 |
| 23 | Truncal obesity (HP:0001956) | 2.34695051 |
| 24 | Subacute progressive viral hepatitis (HP:0006572) | 2.32842646 |
| 25 | Absent frontal sinuses (HP:0002688) | 2.31639386 |
| 26 | Obsessive-compulsive behavior (HP:0000722) | 2.29891364 |
| 27 | Genetic anticipation (HP:0003743) | 2.29621480 |
| 28 | Shallow orbits (HP:0000586) | 2.28889644 |
| 29 | Excessive salivation (HP:0003781) | 2.28478689 |
| 30 | Neoplasm of the oral cavity (HP:0100649) | 2.27997052 |
| 31 | Trigonocephaly (HP:0000243) | 2.27886884 |
| 32 | Renal duplication (HP:0000075) | 2.24983118 |
| 33 | Deviation of the thumb (HP:0009603) | 2.22506097 |
| 34 | High anterior hairline (HP:0009890) | 2.19942338 |
| 35 | Renovascular hypertension (HP:0100817) | 2.18550539 |
| 36 | Hyperacusis (HP:0010780) | 2.17165507 |
| 37 | Biliary tract neoplasm (HP:0100574) | 2.16036735 |
| 38 | Midline defect of the nose (HP:0004122) | 2.14950206 |
| 39 | Cutis marmorata (HP:0000965) | 2.14462363 |
| 40 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.13725543 |
| 41 | Deep philtrum (HP:0002002) | 2.12446652 |
| 42 | Proximal placement of thumb (HP:0009623) | 2.12219891 |
| 43 | Hypoplastic labia majora (HP:0000059) | 2.11851737 |
| 44 | Chromsome breakage (HP:0040012) | 2.10721766 |
| 45 | Gastrointestinal carcinoma (HP:0002672) | 2.07893433 |
| 46 | Malignant gastrointestinal tract tumors (HP:0006749) | 2.07893433 |
| 47 | Broad thumb (HP:0011304) | 2.06976509 |
| 48 | Supernumerary ribs (HP:0005815) | 2.06881132 |
| 49 | Rhabdomyosarcoma (HP:0002859) | 2.02017584 |
| 50 | Elfin facies (HP:0004428) | 1.99809851 |
| 51 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.99748721 |
| 52 | Enlarged penis (HP:0000040) | 1.99609825 |
| 53 | Intestinal atresia (HP:0011100) | 1.98038003 |
| 54 | Acute myeloid leukemia (HP:0004808) | 1.97106914 |
| 55 | Cystic hygroma (HP:0000476) | 1.96569319 |
| 56 | Broad palm (HP:0001169) | 1.96507581 |
| 57 | Abnormal hair whorl (HP:0010721) | 1.96299845 |
| 58 | Cutaneous finger syndactyly (HP:0010554) | 1.95904837 |
| 59 | Vertebral arch anomaly (HP:0008438) | 1.95560526 |
| 60 | Colon cancer (HP:0003003) | 1.93545413 |
| 61 | Aortic aneurysm (HP:0004942) | 1.93372382 |
| 62 | Neoplasm of the adrenal cortex (HP:0100641) | 1.91393837 |
| 63 | Partial agenesis of the corpus callosum (HP:0001338) | 1.91385674 |
| 64 | Skull defect (HP:0001362) | 1.91163686 |
| 65 | Hepatoblastoma (HP:0002884) | 1.91116013 |
| 66 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.90261830 |
| 67 | Neoplasm of striated muscle (HP:0009728) | 1.89030743 |
| 68 | Sandal gap (HP:0001852) | 1.88752922 |
| 69 | Overlapping toe (HP:0001845) | 1.88677887 |
| 70 | Syringomyelia (HP:0003396) | 1.87482010 |
| 71 | Spinal cord lesions (HP:0100561) | 1.87482010 |
| 72 | Abnormality of the nasal septum (HP:0000419) | 1.87366835 |
| 73 | Bowel diverticulosis (HP:0005222) | 1.87042175 |
| 74 | Thyroid carcinoma (HP:0002890) | 1.86963170 |
| 75 | Abnormality of the labia majora (HP:0012881) | 1.86314023 |
| 76 | Protruding tongue (HP:0010808) | 1.86162621 |
| 77 | Large earlobe (HP:0009748) | 1.85198196 |
| 78 | Aqueductal stenosis (HP:0002410) | 1.84516912 |
| 79 | Cortical dysplasia (HP:0002539) | 1.84093859 |
| 80 | Hypoplasia of the maxilla (HP:0000327) | 1.83739282 |
| 81 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.83306852 |
| 82 | Prominent nose (HP:0000448) | 1.82363841 |
| 83 | Abnormality of chromosome stability (HP:0003220) | 1.81694316 |
| 84 | Broad phalanges of the hand (HP:0009768) | 1.79775836 |
| 85 | Facial hemangioma (HP:0000329) | 1.79539753 |
| 86 | Missing ribs (HP:0000921) | 1.78750048 |
| 87 | Abnormality of chromosome segregation (HP:0002916) | 1.76431003 |
| 88 | Abnormality of the antihelix (HP:0009738) | 1.76121112 |
| 89 | Low anterior hairline (HP:0000294) | 1.75129929 |
| 90 | Abnormality of the diencephalon (HP:0010662) | 1.74994113 |
| 91 | Cutaneous syndactyly (HP:0012725) | 1.74618692 |
| 92 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.74375970 |
| 93 | Smooth philtrum (HP:0000319) | 1.73145905 |
| 94 | Bladder carcinoma (HP:0002862) | 1.73027461 |
| 95 | Bladder neoplasm (HP:0009725) | 1.73027461 |
| 96 | Cerebral aneurysm (HP:0004944) | 1.72914248 |
| 97 | Gastroesophageal reflux (HP:0002020) | 1.71864087 |
| 98 | Broad finger (HP:0001500) | 1.70554555 |
| 99 | Fibrous tissue neoplasm (HP:0012316) | 1.70393271 |
| 100 | Hypochromic microcytic anemia (HP:0004840) | 1.70273082 |
| 101 | Mesomelia (HP:0003027) | 1.70056049 |
| 102 | Limited elbow extension (HP:0001377) | 1.68031982 |
| 103 | Thickened helices (HP:0000391) | 1.67592866 |
| 104 | Broad phalanx (HP:0006009) | 1.65881560 |
| 105 | Omphalocele (HP:0001539) | 1.64911365 |
| 106 | Mitral valve prolapse (HP:0001634) | 1.64182153 |
| 107 | Poor coordination (HP:0002370) | 1.64076880 |
| 108 | Sacral dimple (HP:0000960) | 1.63431825 |
| 109 | Progressive cerebellar ataxia (HP:0002073) | 1.63320923 |
| 110 | Myelomeningocele (HP:0002475) | 1.62209964 |
| 111 | Increased number of teeth (HP:0011069) | 1.61050959 |
| 112 | Abnormality of the ischium (HP:0003174) | 1.60499869 |
| 113 | Leiomyosarcoma (HP:0100243) | 1.60396227 |
| 114 | Uterine leiomyosarcoma (HP:0002891) | 1.60396227 |
| 115 | Abnormal number of incisors (HP:0011064) | 1.60343131 |
| 116 | Benign neoplasm of the central nervous system (HP:0100835) | 1.60090414 |
| 117 | Termporal pattern (HP:0011008) | 1.59800847 |
| 118 | Insidious onset (HP:0003587) | 1.59800847 |
| 119 | Cafe-au-lait spot (HP:0000957) | 1.59700929 |
| 120 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 1.59584821 |
| 121 | Broad long bones (HP:0005622) | 1.59164709 |
| 122 | Anal stenosis (HP:0002025) | 1.59151389 |
| 123 | Abnormality of the carotid arteries (HP:0005344) | 1.58945013 |
| 124 | Skin tags (HP:0010609) | 1.58635033 |
| 125 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.57489817 |
| 126 | Shawl scrotum (HP:0000049) | 1.56791515 |
| 127 | Fibroma (HP:0010614) | 1.56777268 |
| 128 | Urethral obstruction (HP:0000796) | 1.56594435 |
| 129 | Oligodactyly (HP:0012165) | 1.56379899 |
| 130 | Tented upper lip vermilion (HP:0010804) | 1.56287809 |
| 131 | Oligodactyly (hands) (HP:0001180) | 1.55560829 |
| 132 | Basal cell carcinoma (HP:0002671) | 1.55326788 |
| 133 | Spina bifida occulta (HP:0003298) | 1.54957218 |
| 134 | Thick eyebrow (HP:0000574) | 1.54609141 |
| 135 | Neoplasm of the small intestine (HP:0100833) | 1.54586862 |
| 136 | Uterine neoplasm (HP:0010784) | 1.53719382 |
| 137 | Pointed chin (HP:0000307) | 1.53193458 |
| 138 | Birth length less than 3rd percentile (HP:0003561) | 1.53063384 |
| 139 | Acute lymphatic leukemia (HP:0006721) | 1.53050332 |
| 140 | Ectopic kidney (HP:0000086) | 1.53050266 |
| 141 | Diastasis recti (HP:0001540) | 1.52922509 |
| 142 | Tracheomalacia (HP:0002779) | 1.52745869 |
| 143 | Abnormality of the epiphyses of the hand (HP:0005924) | 1.52459420 |
| 144 | Selective tooth agenesis (HP:0001592) | 1.52347828 |
| 145 | Overriding aorta (HP:0002623) | 1.52115937 |
| 146 | Asymmetry of the thorax (HP:0001555) | 1.51780333 |
| 147 | Abnormality of the lower motor neuron (HP:0002366) | 1.49963849 |
| 148 | Cupped ear (HP:0000378) | 1.49886308 |
| 149 | Arnold-Chiari malformation (HP:0002308) | 1.49669903 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 4.23780870 |
| 2 | LATS1 | 3.31620272 |
| 3 | FGFR2 | 2.88488241 |
| 4 | CDC7 | 2.88375150 |
| 5 | BCR | 2.53117265 |
| 6 | PNCK | 2.44770828 |
| 7 | EEF2K | 2.43443426 |
| 8 | MAP3K10 | 2.29474798 |
| 9 | STK38L | 2.18514852 |
| 10 | CASK | 2.15273741 |
| 11 | FGFR3 | 2.03406936 |
| 12 | PDGFRA | 2.01268532 |
| 13 | TNIK | 1.97606827 |
| 14 | NEK2 | 1.97085802 |
| 15 | BRD4 | 1.95595434 |
| 16 | SRPK1 | 1.94026791 |
| 17 | CAMK1D | 1.93584636 |
| 18 | PKN2 | 1.88958762 |
| 19 | CDK6 | 1.71741117 |
| 20 | STK3 | 1.63713424 |
| 21 | CAMK1G | 1.59270828 |
| 22 | TRIM28 | 1.50406950 |
| 23 | FGFR1 | 1.48071398 |
| 24 | ERBB3 | 1.46648994 |
| 25 | RIPK1 | 1.46423221 |
| 26 | KSR1 | 1.43638582 |
| 27 | FRK | 1.42832377 |
| 28 | PASK | 1.40265315 |
| 29 | MARK1 | 1.39309985 |
| 30 | PLK3 | 1.34491641 |
| 31 | FLT3 | 1.31837356 |
| 32 | ATR | 1.31425155 |
| 33 | SIK1 | 1.29099495 |
| 34 | MTOR | 1.28523073 |
| 35 | SGK223 | 1.25381325 |
| 36 | SGK494 | 1.25381325 |
| 37 | MKNK1 | 1.21076064 |
| 38 | SCYL2 | 1.21001700 |
| 39 | PTK6 | 1.16621797 |
| 40 | CHEK2 | 1.15789573 |
| 41 | CDK4 | 1.13226362 |
| 42 | PDGFRB | 1.13006015 |
| 43 | MKNK2 | 1.12768641 |
| 44 | MELK | 1.11668849 |
| 45 | CHEK1 | 1.11054013 |
| 46 | NUAK1 | 1.10672383 |
| 47 | SGK3 | 1.10255423 |
| 48 | ATM | 1.10240648 |
| 49 | BRSK2 | 1.03828788 |
| 50 | RPS6KB2 | 1.01195219 |
| 51 | PLK4 | 1.00227952 |
| 52 | CDK9 | 0.99890892 |
| 53 | ALK | 0.99792597 |
| 54 | TRIB3 | 0.98075883 |
| 55 | ZAK | 0.94676287 |
| 56 | FGFR4 | 0.94094769 |
| 57 | STK10 | 0.92940079 |
| 58 | NLK | 0.92116896 |
| 59 | TYRO3 | 0.91700331 |
| 60 | TTK | 0.91190891 |
| 61 | SIK2 | 0.90766120 |
| 62 | DYRK3 | 0.88056951 |
| 63 | STK4 | 0.85052672 |
| 64 | LATS2 | 0.84901579 |
| 65 | SGK2 | 0.84231482 |
| 66 | RET | 0.83747818 |
| 67 | CAMK4 | 0.83484282 |
| 68 | BMPR1B | 0.82892215 |
| 69 | CSNK1D | 0.81366770 |
| 70 | WNK3 | 0.79248927 |
| 71 | CDK2 | 0.79170529 |
| 72 | DMPK | 0.78243028 |
| 73 | TTN | 0.77908198 |
| 74 | MAPK13 | 0.77629553 |
| 75 | NEK1 | 0.76267116 |
| 76 | DYRK1B | 0.75143142 |
| 77 | TGFBR1 | 0.74545889 |
| 78 | DYRK1A | 0.74349764 |
| 79 | AKT3 | 0.72907617 |
| 80 | AURKB | 0.72875241 |
| 81 | TAF1 | 0.71804670 |
| 82 | CDK1 | 0.71505281 |
| 83 | PLK1 | 0.70665740 |
| 84 | DDR2 | 0.69532350 |
| 85 | ITK | 0.67575541 |
| 86 | MAP2K7 | 0.67151295 |
| 87 | TLK1 | 0.66808879 |
| 88 | CLK1 | 0.66326724 |
| 89 | TSSK6 | 0.65572228 |
| 90 | EPHA3 | 0.64868018 |
| 91 | PAK3 | 0.64839618 |
| 92 | EIF2AK3 | 0.62945372 |
| 93 | ACVR1B | 0.62568579 |
| 94 | PIM1 | 0.62032244 |
| 95 | ICK | 0.61781436 |
| 96 | MAP3K4 | 0.61339063 |
| 97 | CDK7 | 0.60768841 |
| 98 | MAP3K8 | 0.60604813 |
| 99 | CSNK1A1L | 0.59216052 |
| 100 | SIK3 | 0.58906646 |
| 101 | YES1 | 0.57417503 |
| 102 | PLK2 | 0.57094187 |
| 103 | NTRK2 | 0.56703153 |
| 104 | CDK3 | 0.56312152 |
| 105 | MAPK14 | 0.54851652 |
| 106 | ERBB2 | 0.54630542 |
| 107 | MARK2 | 0.52871303 |
| 108 | CHUK | 0.52624451 |
| 109 | RPS6KA4 | 0.51317445 |
| 110 | MAPK10 | 0.51055315 |
| 111 | DYRK2 | 0.50277322 |
| 112 | RPS6KB1 | 0.50054831 |
| 113 | PRKDC | 0.49571677 |
| 114 | NEK9 | 0.49279262 |
| 115 | EPHB2 | 0.49213095 |
| 116 | MARK3 | 0.49013804 |
| 117 | UHMK1 | 0.48064898 |
| 118 | MAPK8 | 0.47855813 |
| 119 | SGK1 | 0.47291429 |
| 120 | GSK3B | 0.47242817 |
| 121 | MAP2K4 | 0.47077362 |
| 122 | PAK2 | 0.45700666 |
| 123 | MAP3K7 | 0.45692337 |
| 124 | WNK1 | 0.45315657 |
| 125 | CSNK1G1 | 0.44426916 |
| 126 | WEE1 | 0.44368511 |
| 127 | EPHA2 | 0.43497250 |
| 128 | PAK4 | 0.41621974 |
| 129 | BRSK1 | 0.41058034 |
| 130 | STK24 | 0.40298446 |
| 131 | MAPK15 | 0.39848240 |
| 132 | STK11 | 0.38701005 |
| 133 | KSR2 | 0.38345842 |
| 134 | CSNK1E | 0.37520485 |
| 135 | AKT1 | 0.37348431 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 2.29364992 |
| 2 | Cell cycle_Homo sapiens_hsa04110 | 2.09692574 |
| 3 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.96700647 |
| 4 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.82773831 |
| 5 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.79840249 |
| 6 | Lysine degradation_Homo sapiens_hsa00310 | 1.78706601 |
| 7 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.74790401 |
| 8 | Colorectal cancer_Homo sapiens_hsa05210 | 1.74338067 |
| 9 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.71379106 |
| 10 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.70973628 |
| 11 | Endometrial cancer_Homo sapiens_hsa05213 | 1.66149863 |
| 12 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.64602500 |
| 13 | Adherens junction_Homo sapiens_hsa04520 | 1.61270748 |
| 14 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.61247892 |
| 15 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.54622621 |
| 16 | Alcoholism_Homo sapiens_hsa05034 | 1.48733230 |
| 17 | RNA transport_Homo sapiens_hsa03013 | 1.45726842 |
| 18 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.44085966 |
| 19 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.43262705 |
| 20 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.38969553 |
| 21 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.38411026 |
| 22 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.34294702 |
| 23 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.33200315 |
| 24 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.27569312 |
| 25 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.27329869 |
| 26 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.27309294 |
| 27 | Prostate cancer_Homo sapiens_hsa05215 | 1.25733599 |
| 28 | Glioma_Homo sapiens_hsa05214 | 1.22896454 |
| 29 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.20891242 |
| 30 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.20605918 |
| 31 | HTLV-I infection_Homo sapiens_hsa05166 | 1.18554307 |
| 32 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.16602868 |
| 33 | FoxO signaling pathway_Homo sapiens_hsa04068 | 1.15303347 |
| 34 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.14678405 |
| 35 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.14422672 |
| 36 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.10615406 |
| 37 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.08347780 |
| 38 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.07437399 |
| 39 | Basal transcription factors_Homo sapiens_hsa03022 | 1.05839991 |
| 40 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.05130408 |
| 41 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.04871030 |
| 42 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.04144067 |
| 43 | Focal adhesion_Homo sapiens_hsa04510 | 1.03759765 |
| 44 | Long-term depression_Homo sapiens_hsa04730 | 1.03648579 |
| 45 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.03528943 |
| 46 | Spliceosome_Homo sapiens_hsa03040 | 1.02867829 |
| 47 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.01429236 |
| 48 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.00556028 |
| 49 | Thyroid cancer_Homo sapiens_hsa05216 | 1.00233668 |
| 50 | Mismatch repair_Homo sapiens_hsa03430 | 0.98118660 |
| 51 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.96730883 |
| 52 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.95828625 |
| 53 | Pathways in cancer_Homo sapiens_hsa05200 | 0.95457787 |
| 54 | Viral myocarditis_Homo sapiens_hsa05416 | 0.93714752 |
| 55 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.93404977 |
| 56 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.92917830 |
| 57 | Hepatitis B_Homo sapiens_hsa05161 | 0.90086937 |
| 58 | Insulin resistance_Homo sapiens_hsa04931 | 0.88182169 |
| 59 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.87628953 |
| 60 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.85104902 |
| 61 | Long-term potentiation_Homo sapiens_hsa04720 | 0.84526283 |
| 62 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.83384608 |
| 63 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.82010809 |
| 64 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.81339051 |
| 65 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.80614123 |
| 66 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.79826376 |
| 67 | RNA degradation_Homo sapiens_hsa03018 | 0.79085304 |
| 68 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.78515051 |
| 69 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.77414000 |
| 70 | Gap junction_Homo sapiens_hsa04540 | 0.76962263 |
| 71 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.76686596 |
| 72 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.76638087 |
| 73 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.76070298 |
| 74 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.75206563 |
| 75 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.75190235 |
| 76 | Melanoma_Homo sapiens_hsa05218 | 0.73938154 |
| 77 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.73194768 |
| 78 | Bladder cancer_Homo sapiens_hsa05219 | 0.73079212 |
| 79 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.72566731 |
| 80 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.72433163 |
| 81 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.71784803 |
| 82 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.70601582 |
| 83 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.70173173 |
| 84 | Circadian rhythm_Homo sapiens_hsa04710 | 0.69990220 |
| 85 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.69813972 |
| 86 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.68167675 |
| 87 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.67267663 |
| 88 | Melanogenesis_Homo sapiens_hsa04916 | 0.67118185 |
| 89 | Nicotine addiction_Homo sapiens_hsa05033 | 0.66202241 |
| 90 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.65789569 |
| 91 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.64582928 |
| 92 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.63972410 |
| 93 | Tight junction_Homo sapiens_hsa04530 | 0.61746118 |
| 94 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.61728771 |
| 95 | Axon guidance_Homo sapiens_hsa04360 | 0.61519230 |
| 96 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.61096233 |
| 97 | Homologous recombination_Homo sapiens_hsa03440 | 0.60928302 |
| 98 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.59897921 |
| 99 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.59291339 |
| 100 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.58989785 |
| 101 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.57754101 |
| 102 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.57496290 |
| 103 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.57201101 |
| 104 | Platelet activation_Homo sapiens_hsa04611 | 0.57041252 |
| 105 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.56529530 |
| 106 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.56445070 |
| 107 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.56012693 |
| 108 | Taste transduction_Homo sapiens_hsa04742 | 0.55421613 |
| 109 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.54297028 |
| 110 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.54153504 |
| 111 | Circadian entrainment_Homo sapiens_hsa04713 | 0.53808627 |
| 112 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.53443827 |
| 113 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.53283406 |
| 114 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.53268529 |
| 115 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.52941126 |
| 116 | DNA replication_Homo sapiens_hsa03030 | 0.52588782 |
| 117 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.51520223 |
| 118 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.50978181 |
| 119 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.50055834 |
| 120 | Apoptosis_Homo sapiens_hsa04210 | 0.49623384 |
| 121 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.49013583 |
| 122 | Phototransduction_Homo sapiens_hsa04744 | 0.47882639 |
| 123 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.47247203 |

