UBXN8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA methylation (GO:0031167)5.19202189
2sperm motility (GO:0030317)5.08473227
3binding of sperm to zona pellucida (GO:0007339)4.86340262
4acrosome reaction (GO:0007340)4.85258641
5DNA deamination (GO:0045006)4.77496191
6proteasome assembly (GO:0043248)4.58654778
7spermatid development (GO:0007286)4.56515784
8histone exchange (GO:0043486)4.49075053
9regulation of gonadotropin secretion (GO:0032276)4.35640241
10sperm-egg recognition (GO:0035036)4.32565057
11termination of RNA polymerase III transcription (GO:0006386)4.26679574
12transcription elongation from RNA polymerase III promoter (GO:0006385)4.26679574
13fusion of sperm to egg plasma membrane (GO:0007342)4.19872976
14DNA double-strand break processing (GO:0000729)4.17196190
15regulation of centriole replication (GO:0046599)3.94949746
16centriole replication (GO:0007099)3.94032236
17chromatin remodeling at centromere (GO:0031055)3.91410827
18GTP biosynthetic process (GO:0006183)3.88986707
19ribosomal small subunit assembly (GO:0000028)3.86595556
20amino acid salvage (GO:0043102)3.79259685
21L-methionine salvage (GO:0071267)3.79259685
22L-methionine biosynthetic process (GO:0071265)3.79259685
23guanosine-containing compound biosynthetic process (GO:1901070)3.77354575
24centriole assembly (GO:0098534)3.74180728
25male meiosis (GO:0007140)3.68692053
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.67291959
27multicellular organism reproduction (GO:0032504)3.66602613
28chromosome condensation (GO:0030261)3.66544498
29DNA packaging (GO:0006323)3.62608133
30piRNA metabolic process (GO:0034587)3.56227957
31mitotic metaphase plate congression (GO:0007080)3.53335323
32regulation of meiosis I (GO:0060631)3.52563749
33cell-cell recognition (GO:0009988)3.47856871
34synapsis (GO:0007129)3.46113031
35microtubule depolymerization (GO:0007019)3.46013218
36ribosomal small subunit biogenesis (GO:0042274)3.44388608
37ribosomal large subunit biogenesis (GO:0042273)3.43422364
38coenzyme catabolic process (GO:0009109)3.42894622
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33112055
40purine nucleobase biosynthetic process (GO:0009113)3.30571906
41UTP biosynthetic process (GO:0006228)3.29674321
42motile cilium assembly (GO:0044458)3.28089976
43transcription from mitochondrial promoter (GO:0006390)3.27612538
44peptidyl-histidine modification (GO:0018202)3.20509880
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18932334
46organic cation transport (GO:0015695)3.18229228
47telomere maintenance via semi-conservative replication (GO:0032201)3.18048119
487-methylguanosine mRNA capping (GO:0006370)3.17017302
49regulation of cellular amino acid metabolic process (GO:0006521)3.15765243
50plasma membrane fusion (GO:0045026)3.13861229
51DNA catabolic process, exonucleolytic (GO:0000738)3.12136817
52nucleobase biosynthetic process (GO:0046112)3.11500714
53pseudouridine synthesis (GO:0001522)3.11253271
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10994613
55RNA capping (GO:0036260)3.10555081
567-methylguanosine RNA capping (GO:0009452)3.10555081
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06392405
58protein neddylation (GO:0045116)3.04019722
59microtubule polymerization or depolymerization (GO:0031109)3.03682008
60DNA replication-dependent nucleosome organization (GO:0034723)3.00809230
61DNA replication-dependent nucleosome assembly (GO:0006335)3.00809230
62rRNA modification (GO:0000154)3.00437597
63IMP biosynthetic process (GO:0006188)3.00139148
64spermatid nucleus differentiation (GO:0007289)2.99968887
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99378983
66negative regulation of ligase activity (GO:0051352)2.99378983
67chaperone-mediated protein transport (GO:0072321)2.99231281
68ribonucleoprotein complex biogenesis (GO:0022613)2.97323367
69nuclear pore complex assembly (GO:0051292)2.96843418
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96762364
71respiratory chain complex IV assembly (GO:0008535)2.95000144
72UTP metabolic process (GO:0046051)2.91933340
73DNA methylation involved in gamete generation (GO:0043046)2.91590629
74metaphase plate congression (GO:0051310)2.91106415
75methionine metabolic process (GO:0006555)2.90854297
76DNA replication-independent nucleosome organization (GO:0034724)2.90610970
77DNA replication-independent nucleosome assembly (GO:0006336)2.90610970
78GMP metabolic process (GO:0046037)2.90490563
79mitochondrial RNA metabolic process (GO:0000959)2.90313123
80nuclear pore organization (GO:0006999)2.90137188
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88911034
82DNA strand elongation involved in DNA replication (GO:0006271)2.88268646
83protein targeting to mitochondrion (GO:0006626)2.87892489
84replication fork processing (GO:0031297)2.85818913
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.85342084
86telomere maintenance via recombination (GO:0000722)2.85170742
87* single fertilization (GO:0007338)2.84527034
88germ cell development (GO:0007281)2.84384144
89rRNA processing (GO:0006364)2.84303749
90mRNA cleavage (GO:0006379)2.82502030
91response to pheromone (GO:0019236)2.82288803
92S-adenosylmethionine metabolic process (GO:0046500)2.82253816
93DNA damage response, detection of DNA damage (GO:0042769)2.81924958
94transcription elongation from RNA polymerase I promoter (GO:0006362)2.80251885
95viral mRNA export from host cell nucleus (GO:0046784)2.79983987
96CTP biosynthetic process (GO:0006241)2.78439117
97CTP metabolic process (GO:0046036)2.78439117
98establishment of protein localization to mitochondrial membrane (GO:0090151)2.78018832
99cellular component biogenesis (GO:0044085)2.77757171
100termination of RNA polymerase I transcription (GO:0006363)2.77614200
101DNA strand elongation (GO:0022616)2.77218780
102viral transcription (GO:0019083)2.77101385
103cotranslational protein targeting to membrane (GO:0006613)2.76183045
104neutrophil activation involved in immune response (GO:0002283)2.75789881
105mitotic recombination (GO:0006312)2.74158519
106reproduction (GO:0000003)2.73312112
107single strand break repair (GO:0000012)2.73161094
108methionine biosynthetic process (GO:0009086)2.73008786
109SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.72855502
110rRNA metabolic process (GO:0016072)2.72658157
111protein localization to kinetochore (GO:0034501)2.72487490
112translational termination (GO:0006415)2.71337267
113sex determination (GO:0007530)2.71052934
114microtubule severing (GO:0051013)2.70793530
115maturation of SSU-rRNA (GO:0030490)2.70291333
116protein targeting to ER (GO:0045047)2.70113995
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.69673867
118NADH dehydrogenase complex assembly (GO:0010257)2.69673867
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69673867
120nucleoside diphosphate phosphorylation (GO:0006165)2.69658541
121male gamete generation (GO:0048232)2.69418413
122spermatogenesis (GO:0007283)2.69269199
123regulation of mitochondrial translation (GO:0070129)2.69088392
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69034280
125double-strand break repair via homologous recombination (GO:0000724)2.68950153
126DNA replication initiation (GO:0006270)2.68207305
127positive regulation of ligase activity (GO:0051351)2.67784957
128protein localization to endoplasmic reticulum (GO:0070972)2.67472244
129aldehyde catabolic process (GO:0046185)2.67422318
130GDP-mannose metabolic process (GO:0019673)2.67295760
131ribosome biogenesis (GO:0042254)2.66096089
132DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.66071200
133recombinational repair (GO:0000725)2.65614069
134protein K11-linked ubiquitination (GO:0070979)2.65211447
135cytochrome complex assembly (GO:0017004)2.64964930
136establishment of protein localization to mitochondrion (GO:0072655)2.64283659
137transcription from RNA polymerase I promoter (GO:0006360)2.63438848
138resolution of meiotic recombination intermediates (GO:0000712)2.63313843
139protein polyglutamylation (GO:0018095)2.62788998
140androgen biosynthetic process (GO:0006702)2.62770433
141IMP metabolic process (GO:0046040)2.60625932
142signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.60208664
143signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.60208664
144signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.60208664
145regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.60033162
146disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.59186083
147killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.59186083
148translation (GO:0006412)2.59153726
149exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59101830
150intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.58636902
151signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.58636902
152regulation of centrosome cycle (GO:0046605)2.58563151
153respiratory burst (GO:0045730)2.58154381
154spindle checkpoint (GO:0031577)2.57993196
155mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.57088601
156glycerol ether metabolic process (GO:0006662)2.56975510
157estrogen biosynthetic process (GO:0006703)2.56797664
158pyrimidine nucleoside biosynthetic process (GO:0046134)2.56196739
159non-recombinational repair (GO:0000726)2.56041881
160double-strand break repair via nonhomologous end joining (GO:0006303)2.56041881
161seminiferous tubule development (GO:0072520)2.55915730
162gamete generation (GO:0007276)2.55043177
163mitotic sister chromatid segregation (GO:0000070)2.54812137
164regulation of cellular amine metabolic process (GO:0033238)2.54750623
165regulation of phosphoprotein phosphatase activity (GO:0043666)2.52260449
166negative regulation of T cell differentiation in thymus (GO:0033085)2.52225240
167negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.52037771
168establishment of protein localization to endoplasmic reticulum (GO:0072599)2.51888075
169intracellular protein transmembrane import (GO:0044743)2.51554076
170ribosome assembly (GO:0042255)2.51441105
171cullin deneddylation (GO:0010388)2.51378877
172signal transduction involved in DNA damage checkpoint (GO:0072422)2.50522649
173signal transduction involved in DNA integrity checkpoint (GO:0072401)2.50522649
174signal transduction involved in cell cycle checkpoint (GO:0072395)2.49795236
175DNA replication checkpoint (GO:0000076)2.49749121
176CENP-A containing nucleosome assembly (GO:0034080)2.49250461
177pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.48849821
178maturation of 5.8S rRNA (GO:0000460)2.48263713
179nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47351756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.64311878
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.62908273
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.31417316
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.27999335
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.93310333
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.64923098
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.61133168
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.57057277
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.42684382
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.13100605
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.03225789
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.02631815
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91327238
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80009077
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52992633
16* VDR_23849224_ChIP-Seq_CD4+_Human2.46811541
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40366242
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.30468165
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26168627
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.25441568
21FUS_26573619_Chip-Seq_HEK293_Human2.14822372
22DCP1A_22483619_ChIP-Seq_HELA_Human2.14329129
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.13579453
24IRF8_22096565_ChIP-ChIP_GC-B_Human2.11405366
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08910254
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03758508
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02717965
28E2F7_22180533_ChIP-Seq_HELA_Human2.01193704
29FOXP3_21729870_ChIP-Seq_TREG_Human1.99251154
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98523055
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94265602
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92188628
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92093234
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91577452
35ZNF274_21170338_ChIP-Seq_K562_Hela1.88946099
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87472041
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.86594799
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84111221
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.83611874
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80728233
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.77044918
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76744884
43ELK1_19687146_ChIP-ChIP_HELA_Human1.76565176
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.73102952
45ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.63884979
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.63060110
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62840825
48ER_23166858_ChIP-Seq_MCF-7_Human1.60286409
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58062757
50* GABP_19822575_ChIP-Seq_HepG2_Human1.55106145
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51138303
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49127859
53TTF2_22483619_ChIP-Seq_HELA_Human1.48684395
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48508409
55EWS_26573619_Chip-Seq_HEK293_Human1.48324186
56XRN2_22483619_ChIP-Seq_HELA_Human1.47329651
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47252131
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46658068
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46484948
60P300_19829295_ChIP-Seq_ESCs_Human1.40551335
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39352398
62GBX2_23144817_ChIP-Seq_PC3_Human1.39222090
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.39213389
64* SPI1_23547873_ChIP-Seq_NB4_Human1.38095704
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38054796
66CBP_20019798_ChIP-Seq_JUKART_Human1.38054796
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37602567
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36893610
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36136402
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.35208135
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31985122
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31267569
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31206031
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30445482
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28715397
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28554905
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26598580
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26242645
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25779736
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.24336142
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20307320
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19037597
83* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18263313
84AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16577845
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16443469
86NANOG_19829295_ChIP-Seq_ESCs_Human1.16372016
87SOX2_19829295_ChIP-Seq_ESCs_Human1.16372016
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13881307
89PHF8_20622853_ChIP-Seq_HELA_Human1.12000965
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11674909
91IRF1_19129219_ChIP-ChIP_H3396_Human1.10726623
92* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10133193
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10095086
94* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09218451
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.08896574
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08863814
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08840090
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07939352
99RBPJ_21746931_ChIP-Seq_IB4_Human1.07833682
100HNFA_21074721_ChIP-Seq_CACO-2_Human1.06166836
101* ELK1_22589737_ChIP-Seq_MCF10A_Human1.05339943
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04625168
103NFYB_21822215_ChIP-Seq_K562_Human1.04195612
104CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03185522
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00897151
106MYC_18940864_ChIP-ChIP_HL60_Human1.00243863
107NANOG_20526341_ChIP-Seq_ESCs_Human0.98398547
108* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95669551
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95193129
110ETV1_20927104_ChIP-Seq_GIST48_Human0.95179875
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94593944
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94050769
113RXR_22158963_ChIP-Seq_LIVER_Mouse0.93309776
114AR_21909140_ChIP-Seq_LNCAP_Human0.92967728
115NFE2_27457419_Chip-Seq_LIVER_Mouse0.92298738
116MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92233378
117TBL1_22424771_ChIP-Seq_293T_Human0.90240895
118HTT_18923047_ChIP-ChIP_STHdh_Human0.90018828
119KDM5A_27292631_Chip-Seq_BREAST_Human0.89683309
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.89308177
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89104166
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88763776
123CDX2_22108803_ChIP-Seq_LS180_Human0.88645481
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87163033
125TAF15_26573619_Chip-Seq_HEK293_Human0.85660114
126SOX17_20123909_ChIP-Seq_XEN_Mouse0.82614722
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81534984
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80987545
129VDR_22108803_ChIP-Seq_LS180_Human0.80670385
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80107661
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79203357
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79076854
133PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78109870
134IRF8_27001747_Chip-Seq_BMDM_Mouse0.77425660
135SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74250688
136PPARA_22158963_ChIP-Seq_LIVER_Mouse0.73032043
137ZFX_18555785_ChIP-Seq_MESCs_Mouse0.72914045
138EZH2_27294783_Chip-Seq_NPCs_Mouse0.72847845
139IGF1R_20145208_ChIP-Seq_DFB_Human0.72621463
140PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72494121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ3.79882173
2MP0009840_abnormal_foam_cell3.63059187
3MP0003724_increased_susceptibility_to3.53863019
4MP0009785_altered_susceptibility_to2.85183834
5MP0002139_abnormal_hepatobiliary_system2.72121845
6MP0009379_abnormal_foot_pigmentation2.61597362
7MP0003186_abnormal_redox_activity2.51196601
8MP0001929_abnormal_gametogenesis2.46162010
9MP0001529_abnormal_vocalization2.37488504
10MP0003698_abnormal_male_reproductive2.30746615
11MP0005360_urolithiasis2.24456764
12MP0005085_abnormal_gallbladder_physiolo2.21242367
13MP0003806_abnormal_nucleotide_metabolis2.19947311
14MP0003693_abnormal_embryo_hatching2.19910767
15MP0003718_maternal_effect2.13823756
16MP0008260_abnormal_autophagy2.08224074
17MP0005671_abnormal_response_to2.03401542
18MP0008875_abnormal_xenobiotic_pharmacok2.03278204
19MP0001835_abnormal_antigen_presentation2.02088137
20MP0008995_early_reproductive_senescence1.99579513
21MP0001661_extended_life_span1.96352920
22MP0009697_abnormal_copulation1.92093009
23MP0008058_abnormal_DNA_repair1.87673918
24MP0005451_abnormal_body_composition1.86960429
25MP0002009_preneoplasia1.86639918
26MP0001764_abnormal_homeostasis1.85123652
27MP0002210_abnormal_sex_determination1.83937803
28MP0003656_abnormal_erythrocyte_physiolo1.82417073
29MP0003786_premature_aging1.79639270
30MP0010094_abnormal_chromosome_stability1.79214991
31MP0005025_abnormal_response_to1.77229121
32MP0001905_abnormal_dopamine_level1.76694273
33MP0008004_abnormal_stomach_pH1.75862302
34MP0002148_abnormal_hypersensitivity_rea1.75239011
35MP0010368_abnormal_lymphatic_system1.73929164
36MP0005365_abnormal_bile_salt1.71546167
37MP0003941_abnormal_skin_development1.71469544
38MP0003436_decreased_susceptibility_to1.67694263
39MP0005670_abnormal_white_adipose1.67393829
40MP0003221_abnormal_cardiomyocyte_apopto1.64351808
41MP0005332_abnormal_amino_acid1.63302854
42MP0002419_abnormal_innate_immunity1.60560952
43MP0004019_abnormal_vitamin_homeostasis1.59543835
44MP0001145_abnormal_male_reproductive1.58968002
45MP0005000_abnormal_immune_tolerance1.54352459
46MP0000653_abnormal_sex_gland1.53524498
47MP0002138_abnormal_hepatobiliary_system1.53160787
48MP0005395_other_phenotype1.52754238
49MP0009764_decreased_sensitivity_to1.52554070
50MP0003195_calcinosis1.52539190
51MP0001188_hyperpigmentation1.52359080
52MP0002837_dystrophic_cardiac_calcinosis1.52168630
53MP0001986_abnormal_taste_sensitivity1.49135730
54MP0006036_abnormal_mitochondrial_physio1.48290059
55MP0003890_abnormal_embryonic-extraembry1.46633867
56MP0006035_abnormal_mitochondrial_morpho1.45997524
57MP0009333_abnormal_splenocyte_physiolog1.44626965
58MP0003011_delayed_dark_adaptation1.43561361
59MP0008057_abnormal_DNA_replication1.43313625
60MP0006072_abnormal_retinal_apoptosis1.39359247
61MP0008469_abnormal_protein_level1.38943202
62MP0002161_abnormal_fertility/fecundity1.38794874
63MP0005171_absent_coat_pigmentation1.37417250
64MP0004233_abnormal_muscle_weight1.37328447
65MP0002723_abnormal_immune_serum1.36573395
66MP0003136_yellow_coat_color1.34554894
67MP0006082_CNS_inflammation1.32695672
68MP0004957_abnormal_blastocyst_morpholog1.31477364
69MP0006292_abnormal_olfactory_placode1.31184253
70MP0005084_abnormal_gallbladder_morpholo1.31161192
71MP0003937_abnormal_limbs/digits/tail_de1.28865973
72MP0002102_abnormal_ear_morphology1.26794972
73MP0002638_abnormal_pupillary_reflex1.26683955
74MP0005389_reproductive_system_phenotype1.25105787
75MP0008877_abnormal_DNA_methylation1.21518845
76MP0004782_abnormal_surfactant_physiolog1.18508146
77MP0002452_abnormal_antigen_presenting1.16902535
78MP0002277_abnormal_respiratory_mucosa1.16880385
79MP0001730_embryonic_growth_arrest1.16654350
80MP0002127_abnormal_cardiovascular_syste1.16567597
81MP0004142_abnormal_muscle_tone1.15613702
82MP0001984_abnormal_olfaction1.14702218
83MP0005253_abnormal_eye_physiology1.14552455
84MP0002420_abnormal_adaptive_immunity1.14442767
85MP0001819_abnormal_immune_cell1.14387920
86MP0000372_irregular_coat_pigmentation1.14309578
87MP0005647_abnormal_sex_gland1.14186338
88MP0002876_abnormal_thyroid_physiology1.13366842
89MP0008007_abnormal_cellular_replicative1.13080013
90MP0001845_abnormal_inflammatory_respons1.11497079
91MP0001800_abnormal_humoral_immune1.09681140
92MP0001542_abnormal_bone_strength1.09406575
93MP0003077_abnormal_cell_cycle1.08277319
94MP0003191_abnormal_cellular_cholesterol1.08205896
95MP0008789_abnormal_olfactory_epithelium1.08154311
96MP0005636_abnormal_mineral_homeostasis1.06775039
97MP0008932_abnormal_embryonic_tissue1.06739328
98MP0000716_abnormal_immune_system1.06611493
99MP0002166_altered_tumor_susceptibility1.05570573
100MP0002396_abnormal_hematopoietic_system1.04216548
101MP0005464_abnormal_platelet_physiology1.04156396
102MP0005187_abnormal_penis_morphology1.03813935
103MP0005075_abnormal_melanosome_morpholog1.03406547
104MP0005408_hypopigmentation1.03387087
105MP0001485_abnormal_pinna_reflex1.03368571
106MP0009250_abnormal_appendicular_skeleto1.02873715
107MP0000749_muscle_degeneration1.02734948
108MP0002938_white_spotting1.01933011
109MP0002090_abnormal_vision1.01506651
110MP0005394_taste/olfaction_phenotype1.00292141
111MP0005499_abnormal_olfactory_system1.00292141
112MP0002132_abnormal_respiratory_system0.99358726
113MP0006276_abnormal_autonomic_nervous0.99357816
114MP0004084_abnormal_cardiac_muscle0.97185935
115MP0003646_muscle_fatigue0.96868266
116MP0002006_tumorigenesis0.96807296
117MP0005319_abnormal_enzyme/_coenzyme0.95967825
118MP0005551_abnormal_eye_electrophysiolog0.95928167
119MP0005410_abnormal_fertilization0.95724968
120MP0004381_abnormal_hair_follicle0.95447379
121MP0002398_abnormal_bone_marrow0.95149784
122MP0003111_abnormal_nucleus_morphology0.94802455
123MP0000465_gastrointestinal_hemorrhage0.94473696
124MP0010329_abnormal_lipoprotein_level0.93457383
125MP0003567_abnormal_fetal_cardiomyocyte0.93234089
126MP0000685_abnormal_immune_system0.92324322
127MP0001853_heart_inflammation0.91817863
128MP0002160_abnormal_reproductive_system0.91656153
129MP0002429_abnormal_blood_cell0.91116723
130MP0000689_abnormal_spleen_morphology0.90746316
131MP0005391_vision/eye_phenotype0.90054110
132MP0005584_abnormal_enzyme/coenzyme_acti0.86816766
133MP0001119_abnormal_female_reproductive0.85749559
134MP0003315_abnormal_perineum_morphology0.84774095
135MP0004808_abnormal_hematopoietic_stem0.84543166
136MP0003936_abnormal_reproductive_system0.84499156
137MP0005397_hematopoietic_system_phenotyp0.83464097
138MP0001545_abnormal_hematopoietic_system0.83464097
139MP0009763_increased_sensitivity_to0.81760049
140MP0005387_immune_system_phenotype0.81700697
141MP0001790_abnormal_immune_system0.81700697
142MP0002233_abnormal_nose_morphology0.81443391
143MP0000462_abnormal_digestive_system0.81295088
144MP0005083_abnormal_biliary_tract0.81120954
145MP0003045_fibrosis0.80985842
146MP0001697_abnormal_embryo_size0.80750002
147MP0000049_abnormal_middle_ear0.78933326
148MP0005380_embryogenesis_phenotype0.78243365
149MP0001672_abnormal_embryogenesis/_devel0.78243365
150MP0003868_abnormal_feces_composition0.78050690
151MP0009643_abnormal_urine_homeostasis0.77349066
152MP0001293_anophthalmia0.76335400
153MP0004215_abnormal_myocardial_fiber0.75171859
154MP0003878_abnormal_ear_physiology0.74390759
155MP0005377_hearing/vestibular/ear_phenot0.74390759
156MP0003699_abnormal_female_reproductive0.72635166
157MP0002751_abnormal_autonomic_nervous0.72031076
158MP0002084_abnormal_developmental_patter0.68085842
159MP0000350_abnormal_cell_proliferation0.66648380
160MP0004272_abnormal_basement_membrane0.65650968
161MP0001881_abnormal_mammary_gland0.65523389
162MP0004085_abnormal_heartbeat0.63501961
163MP0002168_other_aberrant_phenotype0.61841057
164MP0003385_abnormal_body_wall0.61835604
165MP0002085_abnormal_embryonic_tissue0.61420310

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)4.80818027
2Gonadotropin excess (HP:0000837)4.31588338
3Chromsome breakage (HP:0040012)3.46632303
4Hypoplasia of the uterus (HP:0000013)3.44609891
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.42384810
6Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.42110251
7Aplasia/Hypoplasia of the tibia (HP:0005772)3.37822088
8Short tibia (HP:0005736)3.33671697
9Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.29529813
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.26328681
11Premature ovarian failure (HP:0008209)3.22432368
12Reduced antithrombin III activity (HP:0001976)3.20392651
13Abnormality of the ileum (HP:0001549)3.19774167
14Male pseudohermaphroditism (HP:0000037)3.08839016
15Abnormality of alanine metabolism (HP:0010916)2.98597097
16Hyperalaninemia (HP:0003348)2.98597097
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.98597097
18Abnormal number of erythroid precursors (HP:0012131)2.95592003
19Meckel diverticulum (HP:0002245)2.95512951
203-Methylglutaconic aciduria (HP:0003535)2.93872151
21Abnormal sex determination (HP:0012244)2.90792492
22Sex reversal (HP:0012245)2.90792492
23Reticulocytopenia (HP:0001896)2.81786086
24Prolonged partial thromboplastin time (HP:0003645)2.81431667
25Abnormality of chromosome stability (HP:0003220)2.80935169
26Type I transferrin isoform profile (HP:0003642)2.76687185
27Mitochondrial inheritance (HP:0001427)2.75292540
28Increased hepatocellular lipid droplets (HP:0006565)2.74381878
29Hepatosplenomegaly (HP:0001433)2.71985687
30Acute necrotizing encephalopathy (HP:0006965)2.71695066
31Sensory axonal neuropathy (HP:0003390)2.71178402
32Birth length less than 3rd percentile (HP:0003561)2.70949618
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69796305
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69796305
35Hepatocellular necrosis (HP:0001404)2.69497602
36Hepatic necrosis (HP:0002605)2.68485954
37Abnormality of cells of the erythroid lineage (HP:0012130)2.68338027
38Abnormality of the preputium (HP:0100587)2.66185499
39Cerebral hypomyelination (HP:0006808)2.62406988
40Hyperglycinemia (HP:0002154)2.61321707
41Renal Fanconi syndrome (HP:0001994)2.60821456
42Aplastic anemia (HP:0001915)2.58232940
43Abnormality of serum amino acid levels (HP:0003112)2.55009462
44Obstructive lung disease (HP:0006536)2.53676612
45Chronic obstructive pulmonary disease (HP:0006510)2.53676612
46Acute encephalopathy (HP:0006846)2.51161974
47Cleft eyelid (HP:0000625)2.51143751
48Pancreatic islet-cell hyperplasia (HP:0004510)2.50665979
49Male infertility (HP:0003251)2.49942074
50Macrocytic anemia (HP:0001972)2.48434432
51Increased CSF lactate (HP:0002490)2.45622778
52Absent/shortened dynein arms (HP:0200106)2.45615516
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.45615516
54Lipid accumulation in hepatocytes (HP:0006561)2.44371570
55Hypothermia (HP:0002045)2.43507007
56Increased serum lactate (HP:0002151)2.42446787
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39684947
58Infertility (HP:0000789)2.38172898
59Hyperglycinuria (HP:0003108)2.37202177
60Abnormality of the 1st metacarpal (HP:0010009)2.35944431
61Abnormality of methionine metabolism (HP:0010901)2.35633228
62Abnormality of pyrimidine metabolism (HP:0004353)2.33953863
63Joint hemorrhage (HP:0005261)2.33829013
64Resting tremor (HP:0002322)2.31966341
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.31486528
66Thrombocytosis (HP:0001894)2.30636825
67Abnormality of the phalanges of the hallux (HP:0010057)2.29394559
68Tubulointerstitial nephritis (HP:0001970)2.28988043
69Lethargy (HP:0001254)2.27890664
70Recurrent gram-negative bacterial infections (HP:0005420)2.27168370
71Small intestinal stenosis (HP:0012848)2.26250795
72Duodenal stenosis (HP:0100867)2.26250795
73Abnormal mitochondria in muscle tissue (HP:0008316)2.25052090
74Abnormality of the proximal phalanges of the hand (HP:0009834)2.24438048
75Exertional dyspnea (HP:0002875)2.24327321
76Abnormal ciliary motility (HP:0012262)2.23145959
77Hypobetalipoproteinemia (HP:0003563)2.22942787
78Spastic paraparesis (HP:0002313)2.22281919
79Azoospermia (HP:0000027)2.19392292
80Abnormal spermatogenesis (HP:0008669)2.18724296
81Pancreatic cysts (HP:0001737)2.17366643
82Abnormal respiratory motile cilium physiology (HP:0012261)2.17295621
83Progressive macrocephaly (HP:0004481)2.16130984
84Encephalitis (HP:0002383)2.16043946
85Poor head control (HP:0002421)2.15077631
86Lactic acidosis (HP:0003128)2.14878367
87Sloping forehead (HP:0000340)2.13992156
88Abnormality of serine family amino acid metabolism (HP:0010894)2.12575026
89Abnormality of glycine metabolism (HP:0010895)2.12575026
90Aplasia/hypoplasia of the humerus (HP:0006507)2.12405830
91Microcytic anemia (HP:0001935)2.12056838
92Cerebral edema (HP:0002181)2.11349556
93Abnormality of the intrinsic pathway (HP:0010989)2.10834874
94Abnormality of urine glucose concentration (HP:0011016)2.10820776
95Glycosuria (HP:0003076)2.10820776
96Abnormality of macular pigmentation (HP:0008002)2.10526065
97Generalized aminoaciduria (HP:0002909)2.08625563
98Prolonged neonatal jaundice (HP:0006579)2.08061365
99Pancytopenia (HP:0001876)2.07795474
100Recurrent bacterial skin infections (HP:0005406)2.07265142
101Increased IgM level (HP:0003496)2.05999811
102Cerebellar dysplasia (HP:0007033)2.05912201
103CNS hypomyelination (HP:0003429)2.05704291
104Recurrent abscess formation (HP:0002722)2.04383695
105Pallor (HP:0000980)2.04101498
106Abnormal lung lobation (HP:0002101)2.03620892
107Chronic hepatic failure (HP:0100626)2.03586479
108Abnormality of macrophages (HP:0004311)2.00727730
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00510962
110Eczematoid dermatitis (HP:0000976)2.00295359
111Abnormal protein glycosylation (HP:0012346)1.99239185
112Abnormal glycosylation (HP:0012345)1.99239185
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99239185
114Abnormal protein N-linked glycosylation (HP:0012347)1.99239185
115Megaloblastic anemia (HP:0001889)1.99169806
116Rough bone trabeculation (HP:0100670)1.98537471
117Absent radius (HP:0003974)1.96732793
118Parakeratosis (HP:0001036)1.96261688
119Horseshoe kidney (HP:0000085)1.95689593
120Severe visual impairment (HP:0001141)1.94823479
121Purpura (HP:0000979)1.93829671
122Clubbing of toes (HP:0100760)1.93504381
123Abnormality of the duodenum (HP:0002246)1.92808918
124Absent thumb (HP:0009777)1.92468005
125Abnormality of the 2nd finger (HP:0004100)1.91329339
126Abnormality of renal resorption (HP:0011038)1.91034039
127Hypophosphatemic rickets (HP:0004912)1.90462931
128Volvulus (HP:0002580)1.89881134
129Abnormality of the middle phalanges of the toes (HP:0010183)1.89644259
130Abnormality of fatty-acid metabolism (HP:0004359)1.88441676
131IgG deficiency (HP:0004315)1.88049568
132Recurrent skin infections (HP:0001581)1.87363563
133Menstrual irregularities (HP:0000858)1.87346862
134Breast hypoplasia (HP:0003187)1.87021086
135Vacuolated lymphocytes (HP:0001922)1.86726541
136Muscle fiber atrophy (HP:0100295)1.85845022
137Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85546125
138Abnormal hemoglobin (HP:0011902)1.85080201
139Proximal tubulopathy (HP:0000114)1.81797065
140Abnormality of the renal collecting system (HP:0004742)1.81388006
141Neutropenia (HP:0001875)1.81281789
142Microvesicular hepatic steatosis (HP:0001414)1.81243776
143Short humerus (HP:0005792)1.80939846
144Short thumb (HP:0009778)1.80890937
145Abnormality of monocarboxylic acid metabolism (HP:0010996)1.80851687
146Short phalanx of the thumb (HP:0009660)1.80260146
147Absent forearm bone (HP:0003953)1.80018895
148Aplasia involving forearm bones (HP:0009822)1.80018895
149Secondary amenorrhea (HP:0000869)1.79842811
150Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78149720
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.77882367
152Elevated erythrocyte sedimentation rate (HP:0003565)1.77701779
153Increased intramyocellular lipid droplets (HP:0012240)1.76752570
154Type 2 muscle fiber atrophy (HP:0003554)1.76659875
155Duplicated collecting system (HP:0000081)1.75940320
156Abnormality of DNA repair (HP:0003254)1.75703052
157Hypoplastic left heart (HP:0004383)1.75536203
158Septate vagina (HP:0001153)1.74033524
159Leukodystrophy (HP:0002415)1.73792552
160Methylmalonic acidemia (HP:0002912)1.73367189
161Exercise intolerance (HP:0003546)1.71703270
162Abnormal respiratory epithelium morphology (HP:0012253)1.71364268
163Abnormal respiratory motile cilium morphology (HP:0005938)1.71364268
164Aplasia/hypoplasia of the uterus (HP:0008684)1.71268026
165Progressive microcephaly (HP:0000253)1.71130727
166Bony spicule pigmentary retinopathy (HP:0007737)1.70839198
167Retinal dysplasia (HP:0007973)1.70784199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.79955219
2STK163.53878627
3NME23.45048325
4STK38L2.94020026
5EIF2AK12.88879757
6BUB12.83407031
7PBK2.64807887
8IRAK42.53419969
9MKNK22.28325638
10PIM22.25348274
11WEE12.23581008
12NEK22.23105308
13MARK32.22399180
14FRK2.20278115
15CDC72.05742936
16MAP3K122.03660289
17LATS22.03645951
18PLK42.00144817
19IRAK31.97653739
20BCKDK1.92424089
21MAP2K71.86298870
22VRK11.81080679
23STK391.76636481
24TTK1.72957616
25ACVR1B1.69422327
26TLK11.66569170
27PDK21.62283261
28INSRR1.57328738
29MKNK11.54465878
30TEC1.54265329
31SRPK11.51352611
32ARAF1.50418017
33EIF2AK31.49615613
34IRAK11.48435819
35NEK91.47730869
36CDK81.43432895
37STK31.38387434
38CASK1.38116862
39TESK21.35690484
40NME11.35531116
41ABL21.35464844
42WNK31.35103990
43BLK1.31281133
44NEK11.30492731
45TXK1.30179373
46DYRK31.26063226
47TSSK61.22047549
48PLK21.21888026
49EIF2AK21.21189959
50BMPR1B1.14029448
51OXSR11.12606161
52BRAF1.10282404
53MST41.09662738
54BMPR21.09376939
55BRSK21.07998479
56CSNK1G31.06681607
57CDK191.03787233
58CCNB11.02305155
59PINK11.02212326
60TRIM281.01295329
61STK381.00616283
62KIT0.99293726
63MAP4K20.97116425
64VRK20.94658295
65IRAK20.94567907
66TAF10.92065367
67PNCK0.91744021
68PIK3CG0.91079263
69TIE10.88668486
70MAP3K140.87747549
71MAP3K60.87407273
72CSNK1G10.86279407
73PRKG20.85718653
74ATR0.85589232
75YES10.84068345
76IKBKE0.83794927
77PLK30.81639401
78BTK0.80986025
79ZAK0.80166473
80IKBKB0.78043620
81ATM0.77517083
82MELK0.76157955
83PLK10.74750570
84CHEK10.73364649
85MAPK40.72691352
86NLK0.72627198
87BCR0.72548073
88TNIK0.71717094
89TGFBR10.71522445
90RPS6KA50.69853377
91ADRBK20.69428222
92RIPK40.66710128
93WNK40.65859598
94KDR0.64776244
95DYRK20.64087372
96FES0.64023224
97MAP4K10.63238675
98LIMK10.63160393
99BRD40.62727297
100OBSCN0.61463130
101BRSK10.57065190
102CSNK2A10.56415230
103GRK10.55852117
104CSNK1G20.55850147
105PAK10.54542519
106LYN0.51560341
107SYK0.51109283
108PIM10.50095057
109CDK40.49919189
110CDK60.49660698
111MUSK0.49628390
112CHEK20.49520137
113CDK30.49128170
114GRK70.47814683
115MAPKAPK50.47233226
116CLK10.45776468
117CDK10.45669333
118NEK60.45262069
119AURKA0.44984380
120PRKD30.44772388
121CSNK1A1L0.44431156
122AURKB0.43684099
123MYLK0.43210175
124TBK10.43092127
125PAK20.42672562
126CDK70.42469941
127MST1R0.42057087
128NUAK10.39965182
129ZAP700.39748194
130CSNK2A20.39154846
131DMPK0.38172004
132MAP3K110.38154284
133MAP3K80.37548972
134PKN10.37547906
135AKT30.36819730
136LCK0.36559420
137CDK20.35640037
138TESK10.35373732
139AKT20.35064865
140PRKCD0.33727019
141TYK20.33510122
142MAP3K40.30472821
143DDR20.30292736
144CSNK1A10.28707182
145STK40.26755255
146RAF10.26667260
147CSNK1E0.23735420

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.49896367
2RNA polymerase_Homo sapiens_hsa030203.40976553
3Ribosome_Homo sapiens_hsa030103.22617423
4DNA replication_Homo sapiens_hsa030302.84793691
5Protein export_Homo sapiens_hsa030602.57268003
6Folate biosynthesis_Homo sapiens_hsa007902.56289499
7Vitamin B6 metabolism_Homo sapiens_hsa007502.49455624
8Pyrimidine metabolism_Homo sapiens_hsa002402.24858046
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14936904
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13548985
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98733321
12Oxidative phosphorylation_Homo sapiens_hsa001901.94555925
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84007037
14Homologous recombination_Homo sapiens_hsa034401.83000073
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76864318
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.68989830
17Parkinsons disease_Homo sapiens_hsa050121.67151702
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61794212
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54088894
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51370850
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50976110
22Basal transcription factors_Homo sapiens_hsa030221.49970150
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46374997
24Mismatch repair_Homo sapiens_hsa034301.45230082
25Nucleotide excision repair_Homo sapiens_hsa034201.45164109
26Spliceosome_Homo sapiens_hsa030401.40605881
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.38230097
28Fatty acid elongation_Homo sapiens_hsa000621.35136553
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33311595
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33182487
31Peroxisome_Homo sapiens_hsa041461.32152852
32Purine metabolism_Homo sapiens_hsa002301.32054856
33Base excision repair_Homo sapiens_hsa034101.29940004
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29449928
35Olfactory transduction_Homo sapiens_hsa047401.28044290
36Pentose phosphate pathway_Homo sapiens_hsa000301.26095073
37Histidine metabolism_Homo sapiens_hsa003401.24927876
38Regulation of autophagy_Homo sapiens_hsa041401.24464486
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.23977269
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23960695
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22218113
42Sulfur relay system_Homo sapiens_hsa041221.20580810
43Fatty acid degradation_Homo sapiens_hsa000711.20068138
44Hedgehog signaling pathway_Homo sapiens_hsa043401.19229558
45Arginine biosynthesis_Homo sapiens_hsa002201.16376495
46Huntingtons disease_Homo sapiens_hsa050161.16002497
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14945141
48Glutathione metabolism_Homo sapiens_hsa004801.10865984
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10515822
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08158210
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.07085486
52Steroid biosynthesis_Homo sapiens_hsa001001.05615108
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05093976
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04725151
55Nitrogen metabolism_Homo sapiens_hsa009101.04208418
56mRNA surveillance pathway_Homo sapiens_hsa030151.04152832
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04110064
58Fanconi anemia pathway_Homo sapiens_hsa034601.00931740
59Sulfur metabolism_Homo sapiens_hsa009201.00650088
60Fatty acid biosynthesis_Homo sapiens_hsa000611.00565175
61Retinol metabolism_Homo sapiens_hsa008300.97304015
62Fatty acid metabolism_Homo sapiens_hsa012120.95167244
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94511460
64Vitamin digestion and absorption_Homo sapiens_hsa049770.93086349
65Allograft rejection_Homo sapiens_hsa053300.92348973
66Arachidonic acid metabolism_Homo sapiens_hsa005900.92338884
67Oocyte meiosis_Homo sapiens_hsa041140.90572555
68Alzheimers disease_Homo sapiens_hsa050100.90225925
69Chemical carcinogenesis_Homo sapiens_hsa052040.88139115
70One carbon pool by folate_Homo sapiens_hsa006700.87424082
71TGF-beta signaling pathway_Homo sapiens_hsa043500.87190458
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87076045
73Metabolic pathways_Homo sapiens_hsa011000.85867175
74RNA transport_Homo sapiens_hsa030130.85682179
75Carbon metabolism_Homo sapiens_hsa012000.84469339
76Non-homologous end-joining_Homo sapiens_hsa034500.84275043
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83605373
78Biosynthesis of amino acids_Homo sapiens_hsa012300.83205814
79Cell cycle_Homo sapiens_hsa041100.80277699
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.79122645
81Staphylococcus aureus infection_Homo sapiens_hsa051500.77979034
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77023015
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76553251
84beta-Alanine metabolism_Homo sapiens_hsa004100.76288521
85Complement and coagulation cascades_Homo sapiens_hsa046100.74954726
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74684977
87N-Glycan biosynthesis_Homo sapiens_hsa005100.72084716
88Rheumatoid arthritis_Homo sapiens_hsa053230.71074480
89Arginine and proline metabolism_Homo sapiens_hsa003300.70297976
90Graft-versus-host disease_Homo sapiens_hsa053320.69850389
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66517086
92Tyrosine metabolism_Homo sapiens_hsa003500.65471552
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65166950
94Epstein-Barr virus infection_Homo sapiens_hsa051690.64119682
95Sphingolipid metabolism_Homo sapiens_hsa006000.63445002
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63029207
97Phototransduction_Homo sapiens_hsa047440.61744713
98Linoleic acid metabolism_Homo sapiens_hsa005910.60628088
99Tryptophan metabolism_Homo sapiens_hsa003800.60079449
100Butanoate metabolism_Homo sapiens_hsa006500.59844224
101Ether lipid metabolism_Homo sapiens_hsa005650.58980610
102Propanoate metabolism_Homo sapiens_hsa006400.58187329
103Phenylalanine metabolism_Homo sapiens_hsa003600.57257010
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57121375
105Asthma_Homo sapiens_hsa053100.56997816
106RNA degradation_Homo sapiens_hsa030180.56901824
107Malaria_Homo sapiens_hsa051440.56240918
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55597927
109Autoimmune thyroid disease_Homo sapiens_hsa053200.54445645
110Antigen processing and presentation_Homo sapiens_hsa046120.53637294
111Primary immunodeficiency_Homo sapiens_hsa053400.52987496
112Fructose and mannose metabolism_Homo sapiens_hsa000510.50475425
113Caffeine metabolism_Homo sapiens_hsa002320.49701435
114p53 signaling pathway_Homo sapiens_hsa041150.49641424
115Other glycan degradation_Homo sapiens_hsa005110.48875293
116Herpes simplex infection_Homo sapiens_hsa051680.48486087
117Selenocompound metabolism_Homo sapiens_hsa004500.46760152
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44716025
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44343563
120Ovarian steroidogenesis_Homo sapiens_hsa049130.41822920
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41563087
122Starch and sucrose metabolism_Homo sapiens_hsa005000.40935561
123Collecting duct acid secretion_Homo sapiens_hsa049660.40671318
124Pyruvate metabolism_Homo sapiens_hsa006200.39341414
125Legionellosis_Homo sapiens_hsa051340.37695858
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.37680736
127ABC transporters_Homo sapiens_hsa020100.36931850
128Phagosome_Homo sapiens_hsa041450.36630753
129Fat digestion and absorption_Homo sapiens_hsa049750.31629402
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31555649
131PPAR signaling pathway_Homo sapiens_hsa033200.29423887
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29365189
133Glycerolipid metabolism_Homo sapiens_hsa005610.29168903
134Systemic lupus erythematosus_Homo sapiens_hsa053220.28749604
135Taste transduction_Homo sapiens_hsa047420.28432903

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