UCHL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.81595255
2synaptic vesicle maturation (GO:0016188)5.78406055
3pyrimidine nucleobase catabolic process (GO:0006208)5.71006294
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.59139803
5synaptic vesicle exocytosis (GO:0016079)5.40158039
6cell migration in hindbrain (GO:0021535)5.39246285
7glutamate secretion (GO:0014047)5.08272617
8negative regulation of microtubule polymerization (GO:0031115)5.01102870
9regulation of synaptic vesicle exocytosis (GO:2000300)4.82383585
10proline transport (GO:0015824)4.57808543
11nucleobase catabolic process (GO:0046113)4.50171566
12neuronal action potential propagation (GO:0019227)4.41327036
13protein localization to synapse (GO:0035418)4.35578547
14neuron cell-cell adhesion (GO:0007158)4.33304446
15locomotory exploration behavior (GO:0035641)4.31201763
16regulation of synaptic vesicle transport (GO:1902803)4.29627814
17postsynaptic membrane organization (GO:0001941)4.29582675
18layer formation in cerebral cortex (GO:0021819)4.20758892
19presynaptic membrane organization (GO:0097090)4.16795227
20neurotransmitter secretion (GO:0007269)4.15539227
21detection of temperature stimulus (GO:0016048)4.08418807
22positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.98198385
23positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.95730986
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.95047504
25neuronal ion channel clustering (GO:0045161)3.94589010
26detection of temperature stimulus involved in sensory perception (GO:0050961)3.92718668
27detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.92718668
28vocalization behavior (GO:0071625)3.90747889
29presynaptic membrane assembly (GO:0097105)3.89360090
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.83777881
31neuromuscular process controlling posture (GO:0050884)3.78788606
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.75583928
33neurofilament cytoskeleton organization (GO:0060052)3.71682491
34transmission of nerve impulse (GO:0019226)3.69840875
35regulation of synapse structural plasticity (GO:0051823)3.69423108
36exploration behavior (GO:0035640)3.69113150
37regulation of neuronal synaptic plasticity (GO:0048168)3.64583775
38positive regulation of synaptic transmission, GABAergic (GO:0032230)3.64529314
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62757994
40dendritic spine morphogenesis (GO:0060997)3.59271214
41regulation of glutamate receptor signaling pathway (GO:1900449)3.57870937
42activation of protein kinase A activity (GO:0034199)3.57227315
43synaptic vesicle endocytosis (GO:0048488)3.52531172
44negative regulation of dendrite morphogenesis (GO:0050774)3.51116948
45regulation of neurotransmitter secretion (GO:0046928)3.47269833
46auditory behavior (GO:0031223)3.44204389
47neurotransmitter transport (GO:0006836)3.43137522
48axon extension (GO:0048675)3.42716854
49neurotransmitter-gated ion channel clustering (GO:0072578)3.36295413
50neuromuscular synaptic transmission (GO:0007274)3.36225505
51regulation of cAMP-dependent protein kinase activity (GO:2000479)3.35700178
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.35653574
53cerebellar Purkinje cell differentiation (GO:0021702)3.34851484
54regulation of vesicle fusion (GO:0031338)3.34319405
55synapse assembly (GO:0007416)3.32738227
56positive regulation of synapse assembly (GO:0051965)3.31408722
57regulation of neurotransmitter transport (GO:0051588)3.26460500
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.25401819
59membrane depolarization during action potential (GO:0086010)3.23713182
60establishment of mitochondrion localization (GO:0051654)3.22542291
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22508298
62neuromuscular process controlling balance (GO:0050885)3.20988117
63establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.20067291
64mitochondrion transport along microtubule (GO:0047497)3.20067291
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.19554386
66calcium-mediated signaling using intracellular calcium source (GO:0035584)3.17831744
67dendrite morphogenesis (GO:0048813)3.17332843
68mating behavior (GO:0007617)3.16876083
69regulation of neurotransmitter levels (GO:0001505)3.16399308
70response to pheromone (GO:0019236)3.16263014
71positive regulation of potassium ion transmembrane transport (GO:1901381)3.14326403
72innervation (GO:0060384)3.13591779
73glycine transport (GO:0015816)3.09457920
74organelle transport along microtubule (GO:0072384)3.08653945
75neuron recognition (GO:0008038)3.07953615
76dopamine receptor signaling pathway (GO:0007212)3.07196805
77cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.06795917
78cell communication by electrical coupling (GO:0010644)3.05486537
79positive regulation of dendritic spine morphogenesis (GO:0061003)3.03921462
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.01666222
81gamma-aminobutyric acid transport (GO:0015812)3.01574464
82* axon cargo transport (GO:0008088)3.01217035
83neuron projection extension (GO:1990138)3.00754394
84vesicle transport along microtubule (GO:0047496)2.99467937
85synaptic transmission, glutamatergic (GO:0035249)2.98811829
86ionotropic glutamate receptor signaling pathway (GO:0035235)2.98189861
87neuronal action potential (GO:0019228)2.97974368
88response to auditory stimulus (GO:0010996)2.97490591
89glutamate receptor signaling pathway (GO:0007215)2.97070907
90axonal fasciculation (GO:0007413)2.95783393
91response to pain (GO:0048265)2.95638401
92synaptic vesicle transport (GO:0048489)2.91540175
93establishment of synaptic vesicle localization (GO:0097480)2.91540175
94neuron-neuron synaptic transmission (GO:0007270)2.91536041
95negative regulation of dendrite development (GO:2000171)2.89687734
96regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89005961
97chaperone-mediated protein transport (GO:0072321)2.86685422
98retinal ganglion cell axon guidance (GO:0031290)2.85116782
99short-term memory (GO:0007614)2.84527186
100cellular potassium ion homeostasis (GO:0030007)2.83782902
101mechanosensory behavior (GO:0007638)2.83567373
102behavioral response to ethanol (GO:0048149)2.83172839
103establishment of vesicle localization (GO:0051650)2.82296109
104regulation of respiratory system process (GO:0044065)2.81592767
105positive regulation of neurotransmitter transport (GO:0051590)2.81454057
106neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.80994751
107regulation of calcium ion-dependent exocytosis (GO:0017158)2.80575940
108regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.80195662
109positive regulation of synapse maturation (GO:0090129)2.80058585
110synaptic transmission (GO:0007268)2.79580029
111regulation of dopamine secretion (GO:0014059)2.77861176
112adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.77106259
113sodium ion export (GO:0071436)2.76188268
114regulation of synaptic transmission, dopaminergic (GO:0032225)2.76148376
115central nervous system projection neuron axonogenesis (GO:0021952)2.75802174
116synapse organization (GO:0050808)2.75664500
117regulation of microtubule polymerization (GO:0031113)2.75467229
118prepulse inhibition (GO:0060134)2.75308468
119substrate-independent telencephalic tangential migration (GO:0021826)2.75035424
120substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.75035424
121positive regulation of dendritic spine development (GO:0060999)2.74564634
122regulation of synaptic plasticity (GO:0048167)2.73905393
123regulation of excitatory postsynaptic membrane potential (GO:0060079)2.73585483
124sequestering of actin monomers (GO:0042989)2.73194072
125behavioral response to nicotine (GO:0035095)2.73005243
126negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.71272032
127* adult walking behavior (GO:0007628)2.71101466
128behavioral response to cocaine (GO:0048148)2.70963044
129membrane depolarization (GO:0051899)2.70763735
130regulation of postsynaptic membrane potential (GO:0060078)2.69689435
131behavioral fear response (GO:0001662)2.63686249
132behavioral defense response (GO:0002209)2.63686249
133cerebellar granule cell differentiation (GO:0021707)2.60248987
134positive regulation of membrane potential (GO:0045838)2.58884667
135regulation of synapse assembly (GO:0051963)2.57629029
136dendritic spine organization (GO:0097061)2.57504568
137dendrite development (GO:0016358)2.56494066
138protein polyglutamylation (GO:0018095)2.52983353
139ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.52095141
140hippocampus development (GO:0021766)2.50340759
141cerebellar Purkinje cell layer development (GO:0021680)2.50061398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88285790
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06522608
3REST_21632747_ChIP-Seq_MESCs_Mouse3.00488159
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98687852
5JARID2_20075857_ChIP-Seq_MESCs_Mouse2.91240926
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.86140832
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83663110
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75561298
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75561298
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.65019567
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.61661508
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60177711
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52309533
14GBX2_23144817_ChIP-Seq_PC3_Human2.51151533
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46534659
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.45981138
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41438806
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.39694620
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37183821
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35457396
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.33507702
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33129493
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31566111
24ERG_21242973_ChIP-ChIP_JURKAT_Human2.18961048
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.15122931
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13725034
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.10232071
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07742735
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.03160069
30DROSHA_22980978_ChIP-Seq_HELA_Human1.93594165
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83329898
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80290621
33RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.77898951
34* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75015151
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67875227
36AR_21572438_ChIP-Seq_LNCaP_Human1.67311358
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66864587
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66051538
39TAF15_26573619_Chip-Seq_HEK293_Human1.64131537
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.63111661
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62219475
42ZNF263_19887448_ChIP-Seq_K562_Human1.59630362
43* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.50849778
44KDM2B_26808549_Chip-Seq_K562_Human1.46187130
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41038248
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39138246
47CTCF_27219007_Chip-Seq_Bcells_Human1.38530108
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.38385416
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37641300
50RNF2_27304074_Chip-Seq_NSC_Mouse1.34716715
51TET1_21490601_ChIP-Seq_MESCs_Mouse1.30591669
52FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30450627
53ZNF274_21170338_ChIP-Seq_K562_Hela1.30244359
54* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29802470
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29377794
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28516720
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27906289
58SMAD4_21799915_ChIP-Seq_A2780_Human1.26366296
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24894400
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.24419982
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21932719
62* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13399815
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.09530767
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09332847
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08544243
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08481814
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.06684517
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04624249
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03200797
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02768517
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02749912
72CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99553376
73P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99553250
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99394863
75SMAD3_21741376_ChIP-Seq_ESCs_Human0.98732150
76SOX2_16153702_ChIP-ChIP_HESCs_Human0.96663409
77THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96572204
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96318112
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96107934
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96107934
81CBX2_27304074_Chip-Seq_ESCs_Mouse0.95929170
82* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95576383
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95502095
84REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93778931
85AR_19668381_ChIP-Seq_PC3_Human0.93249377
86* SOX9_26525672_Chip-Seq_HEART_Mouse0.92768569
87FUS_26573619_Chip-Seq_HEK293_Human0.92724493
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91966324
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91851537
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91608619
91IRF1_19129219_ChIP-ChIP_H3396_Human0.91308718
92* P300_19829295_ChIP-Seq_ESCs_Human0.91194656
93* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90216589
94* AR_25329375_ChIP-Seq_VCAP_Human0.89916289
95OCT4_19829295_ChIP-Seq_ESCs_Human0.89840010
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89567036
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88659385
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87869018
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87409565
100STAT3_23295773_ChIP-Seq_U87_Human0.86626249
101LXR_22292898_ChIP-Seq_THP-1_Human0.86480510
102* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86417759
103POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.86027344
104MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85600920
105YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85134700
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85113183
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83888702
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83361373
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82538599
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80778574
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80340710
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79775881
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78561289
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78220298
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77549712
116* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77509426
117* SMAD4_21741376_ChIP-Seq_HESCs_Human0.77277965
118JUN_21703547_ChIP-Seq_K562_Human0.77258985
119AHR_22903824_ChIP-Seq_MCF-7_Human0.76786780
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.76682440
121* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.76255337
122* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76131769
123IGF1R_20145208_ChIP-Seq_DFB_Human0.76030681
124PRDM14_20953172_ChIP-Seq_ESCs_Human0.75039466
125SMAD3_21741376_ChIP-Seq_EPCs_Human0.74049464
126KLF4_19829295_ChIP-Seq_ESCs_Human0.73908887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity4.69741002
2MP0004270_analgesia4.25027752
3MP0001968_abnormal_touch/_nociception4.00110064
4MP0002735_abnormal_chemical_nociception3.76102845
5MP0003880_abnormal_central_pattern3.69531756
6* MP0003635_abnormal_synaptic_transmissio3.39670567
7MP0002822_catalepsy3.36108984
8MP0002734_abnormal_mechanical_nocicepti3.33665005
9MP0006276_abnormal_autonomic_nervous3.25077202
10MP0002736_abnormal_nociception_after3.15745942
11* MP0002733_abnormal_thermal_nociception3.09561227
12MP0004858_abnormal_nervous_system2.93187843
13* MP0001970_abnormal_pain_threshold2.84714644
14MP0009745_abnormal_behavioral_response2.80814268
15MP0002063_abnormal_learning/memory/cond2.78110884
16MP0002064_seizures2.63801888
17MP0005423_abnormal_somatic_nervous2.52643101
18MP0009046_muscle_twitch2.38095474
19* MP0002572_abnormal_emotion/affect_behav2.36297231
20MP0002184_abnormal_innervation2.36069233
21MP0002272_abnormal_nervous_system2.34499608
22MP0003121_genomic_imprinting2.20270149
23MP0001440_abnormal_grooming_behavior2.19358072
24MP0004811_abnormal_neuron_physiology2.06965544
25MP0000778_abnormal_nervous_system1.97976423
26MP0001905_abnormal_dopamine_level1.89597495
27* MP0002067_abnormal_sensory_capabilities1.84812927
28MP0006292_abnormal_olfactory_placode1.83651433
29MP0005386_behavior/neurological_phenoty1.81203455
30MP0004924_abnormal_behavior1.81203455
31* MP0000955_abnormal_spinal_cord1.80547510
32MP0001486_abnormal_startle_reflex1.79608992
33MP0001529_abnormal_vocalization1.77685589
34MP0001984_abnormal_olfaction1.70356774
35MP0010386_abnormal_urinary_bladder1.68446769
36MP0003123_paternal_imprinting1.66102639
37MP0002751_abnormal_autonomic_nervous1.65947914
38MP0003122_maternal_imprinting1.59364381
39MP0002557_abnormal_social/conspecific_i1.58312670
40MP0001501_abnormal_sleep_pattern1.57987547
41MP0003329_amyloid_beta_deposits1.53882470
42* MP0002882_abnormal_neuron_morphology1.51930026
43MP0002638_abnormal_pupillary_reflex1.48349664
44MP0002102_abnormal_ear_morphology1.46862807
45MP0005646_abnormal_pituitary_gland1.42400551
46MP0002909_abnormal_adrenal_gland1.41741124
47MP0005645_abnormal_hypothalamus_physiol1.39848145
48MP0000751_myopathy1.39096280
49MP0008569_lethality_at_weaning1.36450846
50* MP0002066_abnormal_motor_capabilities/c1.33925026
51MP0004142_abnormal_muscle_tone1.32825002
52MP0004133_heterotaxia1.31160159
53MP0001502_abnormal_circadian_rhythm1.24551847
54MP0001986_abnormal_taste_sensitivity1.24411234
55MP0003879_abnormal_hair_cell1.23297871
56MP0000049_abnormal_middle_ear1.16233633
57MP0005551_abnormal_eye_electrophysiolog1.16109616
58MP0003633_abnormal_nervous_system1.13399052
59MP0008872_abnormal_physiological_respon1.09748484
60MP0003890_abnormal_embryonic-extraembry1.07235950
61MP0003787_abnormal_imprinting1.04303183
62* MP0002152_abnormal_brain_morphology1.04132953
63* MP0002752_abnormal_somatic_nervous1.01497892
64MP0002653_abnormal_ependyma_morphology1.00929830
65MP0005499_abnormal_olfactory_system1.00644207
66MP0005394_taste/olfaction_phenotype1.00644207
67MP0003631_nervous_system_phenotype1.00132197
68MP0009780_abnormal_chondrocyte_physiolo0.97512945
69MP0008874_decreased_physiological_sensi0.94455355
70MP0003634_abnormal_glial_cell0.91027121
71* MP0002229_neurodegeneration0.90007822
72MP0001348_abnormal_lacrimal_gland0.87679280
73MP0000026_abnormal_inner_ear0.85702538
74MP0003119_abnormal_digestive_system0.84413390
75MP0000538_abnormal_urinary_bladder0.84071312
76MP0005623_abnormal_meninges_morphology0.83096714
77MP0003938_abnormal_ear_development0.81597336
78MP0003942_abnormal_urinary_system0.81248923
79MP0004145_abnormal_muscle_electrophysio0.81244243
80MP0003283_abnormal_digestive_organ0.81084305
81MP0006072_abnormal_retinal_apoptosis0.78696294
82MP0010030_abnormal_orbit_morphology0.77862928
83MP0005195_abnormal_posterior_eye0.77482729
84MP0001188_hyperpigmentation0.76880449
85MP0004885_abnormal_endolymph0.76192195
86MP0008877_abnormal_DNA_methylation0.75470416
87MP0002081_perinatal_lethality0.74984131
88MP0001177_atelectasis0.74831433
89MP0001293_anophthalmia0.73956367
90* MP0002069_abnormal_eating/drinking_beha0.73229045
91MP0001963_abnormal_hearing_physiology0.70583502
92MP0002233_abnormal_nose_morphology0.70577490
93MP0003861_abnormal_nervous_system0.69588225
94MP0008961_abnormal_basal_metabolism0.69274793
95MP0005535_abnormal_body_temperature0.68361883
96MP0000534_abnormal_ureter_morphology0.68202424
97MP0005253_abnormal_eye_physiology0.67192544
98MP0003937_abnormal_limbs/digits/tail_de0.66493377
99MP0004233_abnormal_muscle_weight0.66417405
100MP0004742_abnormal_vestibular_system0.66145752
101MP0005187_abnormal_penis_morphology0.65389655
102MP0001485_abnormal_pinna_reflex0.65362667
103MP0000631_abnormal_neuroendocrine_gland0.64703638
104MP0002837_dystrophic_cardiac_calcinosis0.63254485
105MP0003755_abnormal_palate_morphology0.62895788
106MP0003632_abnormal_nervous_system0.60957920
107MP0003646_muscle_fatigue0.60950958
108MP0001299_abnormal_eye_distance/0.60833004
109MP0003137_abnormal_impulse_conducting0.60637341
110MP0008789_abnormal_olfactory_epithelium0.59100918
111MP0000747_muscle_weakness0.58587554
112MP0000639_abnormal_adrenal_gland0.58372035
113MP0005171_absent_coat_pigmentation0.57603664
114MP0004085_abnormal_heartbeat0.57491234
115MP0001664_abnormal_digestion0.55737518
116MP0001943_abnormal_respiration0.55624623
117MP0000372_irregular_coat_pigmentation0.53173613
118MP0002163_abnormal_gland_morphology0.52033525
119MP0000604_amyloidosis0.51050681
120MP0010769_abnormal_survival0.50940778
121* MP0003956_abnormal_body_size0.50114320
122MP0010770_preweaning_lethality0.49846460
123MP0002082_postnatal_lethality0.49846460

Predicted human phenotypes

RankGene SetZ-score
1* Myokymia (HP:0002411)7.06841498
2Focal motor seizures (HP:0011153)4.98444426
3Limb dystonia (HP:0002451)4.50391929
4Focal seizures (HP:0007359)4.50321930
5Visual hallucinations (HP:0002367)4.41112144
6Pheochromocytoma (HP:0002666)4.38630965
7Febrile seizures (HP:0002373)4.02553311
8Atonic seizures (HP:0010819)3.96644085
9Action tremor (HP:0002345)3.94823310
10Neuroendocrine neoplasm (HP:0100634)3.93378520
11Progressive cerebellar ataxia (HP:0002073)3.85887582
12Supranuclear gaze palsy (HP:0000605)3.79720154
13Ankle clonus (HP:0011448)3.70158394
14Failure to thrive in infancy (HP:0001531)3.59309559
15Ulnar claw (HP:0001178)3.55760904
16Hypothermia (HP:0002045)3.48553915
17Termporal pattern (HP:0011008)3.37750566
18Insidious onset (HP:0003587)3.37750566
19Epileptic encephalopathy (HP:0200134)3.33828000
20Amblyopia (HP:0000646)3.21981220
21Absence seizures (HP:0002121)3.21885198
22Cortical dysplasia (HP:0002539)3.11412449
23Hypercortisolism (HP:0001578)3.10401972
24Generalized tonic-clonic seizures (HP:0002069)3.07616144
25Drooling (HP:0002307)2.87826825
26Dialeptic seizures (HP:0011146)2.83596920
27Urinary bladder sphincter dysfunction (HP:0002839)2.80730829
28Abnormal eating behavior (HP:0100738)2.79664931
29Mutism (HP:0002300)2.78897434
30Urinary urgency (HP:0000012)2.78817499
31Neoplasm of the peripheral nervous system (HP:0100007)2.77346831
32Hypoventilation (HP:0002791)2.75354252
33Torticollis (HP:0000473)2.75116730
34Abnormality of the lower motor neuron (HP:0002366)2.73642258
35Papilledema (HP:0001085)2.68861917
36Impaired pain sensation (HP:0007328)2.65702839
37Abnormality of pain sensation (HP:0010832)2.65702839
38Depression (HP:0000716)2.65573147
39Impaired vibration sensation in the lower limbs (HP:0002166)2.65291795
40Abnormality of the corticospinal tract (HP:0002492)2.64934368
41Polyphagia (HP:0002591)2.64716030
42Lissencephaly (HP:0001339)2.64553829
43Anxiety (HP:0000739)2.61518230
44Orthostatic hypotension (HP:0001278)2.57762175
45Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.57709225
46Excessive salivation (HP:0003781)2.56645752
47Focal dystonia (HP:0004373)2.51576363
48Annular pancreas (HP:0001734)2.49277087
49Aplasia/Hypoplasia of the brainstem (HP:0007362)2.48253513
50Hypoplasia of the brainstem (HP:0002365)2.48253513
51Craniofacial dystonia (HP:0012179)2.48102822
52Spastic gait (HP:0002064)2.47105978
53Pachygyria (HP:0001302)2.44142330
54Agitation (HP:0000713)2.43445625
55Spastic tetraplegia (HP:0002510)2.39145360
56Congenital primary aphakia (HP:0007707)2.36047879
57Truncal ataxia (HP:0002078)2.35436791
58Abnormal autonomic nervous system physiology (HP:0012332)2.32453041
59Abnormality of the vocal cords (HP:0008777)2.27830582
60Nephrogenic diabetes insipidus (HP:0009806)2.26899295
61Medial flaring of the eyebrow (HP:0010747)2.26886305
62Anosmia (HP:0000458)2.26582314
63Menstrual irregularities (HP:0000858)2.25029367
64Poor suck (HP:0002033)2.20232570
65Progressive inability to walk (HP:0002505)2.19119555
66Hammertoe (HP:0001765)2.18385638
67Esotropia (HP:0000565)2.18261529
68Retinal dysplasia (HP:0007973)2.17380768
69Fetal akinesia sequence (HP:0001989)2.16589252
70Ventricular fibrillation (HP:0001663)2.14271170
71Amyotrophic lateral sclerosis (HP:0007354)2.13826114
72Postural tremor (HP:0002174)2.13235503
73Delusions (HP:0000746)2.12675137
74Specific learning disability (HP:0001328)2.12608066
75Abnormal hair whorl (HP:0010721)2.09889463
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09312769
77Degeneration of the lateral corticospinal tracts (HP:0002314)2.09312769
78Lower limb muscle weakness (HP:0007340)2.09133059
79Poor eye contact (HP:0000817)2.06582512
80Cerebral hypomyelination (HP:0006808)2.04776292
81Vaginal atresia (HP:0000148)2.04215823
82Megalencephaly (HP:0001355)2.02987420
83Hemiparesis (HP:0001269)2.02707771
84Sleep apnea (HP:0010535)2.00926534
85Foot dorsiflexor weakness (HP:0009027)2.00352554
86Genital tract atresia (HP:0001827)1.99303470
87Dysautonomia (HP:0002459)1.98455420
88Rapidly progressive (HP:0003678)1.97360013
89Clonus (HP:0002169)1.95768595
90Hepatoblastoma (HP:0002884)1.95663681
91Septo-optic dysplasia (HP:0100842)1.95397713
92Morphological abnormality of the pyramidal tract (HP:0002062)1.93642917
93Bradykinesia (HP:0002067)1.92968266
94Gaze-evoked nystagmus (HP:0000640)1.92595134
95Hyperthyroidism (HP:0000836)1.92353815
96Peripheral hypomyelination (HP:0007182)1.91913555
97Akinesia (HP:0002304)1.91278108
98Dysdiadochokinesis (HP:0002075)1.90186453
99Postural instability (HP:0002172)1.89764336
100Optic nerve hypoplasia (HP:0000609)1.89681565
101Abnormality of the labia minora (HP:0012880)1.86827584
102Gait imbalance (HP:0002141)1.86487355
103Insomnia (HP:0100785)1.86277416
104Status epilepticus (HP:0002133)1.85337467
105Impaired social interactions (HP:0000735)1.84303200
106Abnormal social behavior (HP:0012433)1.84303200
107Broad-based gait (HP:0002136)1.83735736
108Hypoplasia of the corpus callosum (HP:0002079)1.82803375
109EEG with generalized epileptiform discharges (HP:0011198)1.81958840
110Thyroid carcinoma (HP:0002890)1.80535424
111Epileptiform EEG discharges (HP:0011182)1.79876807
112Type II lissencephaly (HP:0007260)1.79766544
113Psychosis (HP:0000709)1.79569956
114Abnormality of the foot musculature (HP:0001436)1.79569533
115Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.79431226
116Hypsarrhythmia (HP:0002521)1.78479721
117Oligomenorrhea (HP:0000876)1.78206095
118Obstructive sleep apnea (HP:0002870)1.77168955
119Generalized hypotonia (HP:0001290)1.76623687
120Sensory axonal neuropathy (HP:0003390)1.76309830
121* Dysmetria (HP:0001310)1.75804111
122Growth hormone excess (HP:0000845)1.75422197
123Steppage gait (HP:0003376)1.74655847
124Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74322142
125Hand muscle atrophy (HP:0009130)1.73213074
126Labial hypoplasia (HP:0000066)1.71719937
127CNS hypomyelination (HP:0003429)1.69806243
128Pancreatic fibrosis (HP:0100732)1.67516180
129Broad foot (HP:0001769)1.66202765
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65634316
131Molar tooth sign on MRI (HP:0002419)1.65190712
132Abnormality of midbrain morphology (HP:0002418)1.65190712
133Growth hormone deficiency (HP:0000824)1.64893668
134Poor coordination (HP:0002370)1.64869585
135Abnormality of binocular vision (HP:0011514)1.63393737
136Diplopia (HP:0000651)1.63393737
137Hypogonadotrophic hypogonadism (HP:0000044)1.63157033
138Rib fusion (HP:0000902)1.62469591
139Hypoplastic female external genitalia (HP:0012815)1.61995221
140Shawl scrotum (HP:0000049)1.61826589
141Hyperventilation (HP:0002883)1.61183423
142Narrow forehead (HP:0000341)1.59476517
143Restlessness (HP:0000711)1.59172528
144Muscular hypotonia of the trunk (HP:0008936)1.58574678
145Polymicrogyria (HP:0002126)1.58353459
146Intention tremor (HP:0002080)1.56511410
147Atrophy/Degeneration involving motor neurons (HP:0007373)1.55985482
148Absent speech (HP:0001344)1.55863612
149Genetic anticipation (HP:0003743)1.55481885

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.33029133
2NTRK33.47700373
3GRK53.46738404
4MARK13.34069266
5KSR23.14260818
6MINK12.81088456
7NTRK12.71699827
8ARAF2.56949422
9MAP3K42.55445922
10MAP3K122.54924349
11LATS22.40206786
12MAP3K22.10400034
13BCR2.04608305
14PAK61.97895925
15MAP2K71.96510544
16DAPK21.95955282
17LIMK11.95948924
18PHKG21.88691811
19PHKG11.88691811
20MAPK131.81778956
21WNK31.76510977
22TNIK1.74833719
23NTRK21.73615025
24UHMK11.71022674
25MAP2K41.69010353
26EPHA41.65596397
27LMTK21.63300866
28STK161.63138414
29PRKD31.50459489
30DAPK11.43251934
31TRIM281.36075654
32RET1.34573334
33TAOK11.29196986
34CDK51.27904677
35MAP3K61.26062937
36TYRO31.25210177
37KSR11.18910089
38PLK21.15989901
39MATK1.14996901
40CSNK1G21.12615828
41CDK141.10184565
42CAMKK11.08770351
43DYRK1B1.05231741
44DYRK31.04440725
45CDK181.02716488
46CDK151.00198535
47PINK10.97148163
48CSNK1G30.92120268
49DYRK20.91256254
50CDK11A0.90863178
51RAF10.87880245
52STK380.87719059
53CDK190.86279876
54PRKCG0.83996913
55SIK20.83114877
56MAPKAPK50.79245772
57NEK10.78812351
58DDR20.78555028
59ICK0.78297583
60MAP2K10.77978820
61CASK0.77781082
62PNCK0.74213818
63CAMK2A0.74168403
64MAP3K10.73776929
65BRAF0.73697232
66PKN10.73477670
67RPS6KA20.70718836
68TESK10.70030009
69MAPKAPK30.69237757
70SGK2230.68581152
71SGK4940.68581152
72MAP4K20.68249325
73GRK70.67116372
74CAMK10.64961864
75ADRBK10.64334708
76MAP3K110.62741439
77PAK30.62353612
78FGR0.61228615
79CSNK1E0.59837998
80CSNK1G10.59198760
81CAMK2B0.58030309
82WNK40.55897930
83CAMK1G0.55436697
84PTK2B0.55268004
85MARK20.54406295
86CAMKK20.54348663
87CAMK2G0.54155467
88AURKA0.53847393
89RIPK40.53377965
90SIK30.53273446
91OXSR10.51622046
92TSSK60.51216484
93SCYL20.50434578
94PRKCZ0.49105086
95STK110.47742494
96CDC42BPA0.46957792
97FER0.46907257
98TESK20.46610653
99BMPR1B0.44745260
100CSNK1A1L0.44236415
101BCKDK0.43364293
102PRPF4B0.42124764
103CAMK1D0.40721284
104ERBB30.40713654
105CSNK1D0.40681054
106GRK10.40209981
107CSNK1A10.39972186
108PLK30.39683355
109PRKACA0.38904160
110CDC70.38804752
111ALK0.37244723
112TNK20.37115949
113PRKAA10.36726505
114BRSK10.36464057
115RPS6KA30.35673855
116CAMK40.35348556
117PRKG10.35211246
118CAMK2D0.34673895
119MAPK90.34662413
120PRKCE0.34598974
121PRKDC0.34469346
122NME10.33981947
123DAPK30.33729008
124DYRK1A0.33078764
125SGK10.32880502
126PTK20.31609670
127PLK10.31425989
128MAP3K130.30606594
129PRKCH0.30585691
130WNK10.29635394
131PIM20.29527606
132SGK20.28984306
133EPHB20.28728957
134FES0.28451268

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.08708668
2Olfactory transduction_Homo sapiens_hsa047402.83923833
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.71005797
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.65788272
5Nicotine addiction_Homo sapiens_hsa050332.58086700
6Dopaminergic synapse_Homo sapiens_hsa047282.27994698
7Circadian entrainment_Homo sapiens_hsa047132.20402781
8GABAergic synapse_Homo sapiens_hsa047272.14645750
9Amphetamine addiction_Homo sapiens_hsa050312.12766047
10Long-term potentiation_Homo sapiens_hsa047202.10733581
11Collecting duct acid secretion_Homo sapiens_hsa049662.06084047
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.05912684
13Cholinergic synapse_Homo sapiens_hsa047252.04818933
14Glutamatergic synapse_Homo sapiens_hsa047242.04710408
15Morphine addiction_Homo sapiens_hsa050321.85677107
16Insulin secretion_Homo sapiens_hsa049111.80217943
17Oxidative phosphorylation_Homo sapiens_hsa001901.79538243
18Cocaine addiction_Homo sapiens_hsa050301.71170905
19Salivary secretion_Homo sapiens_hsa049701.69356769
20Serotonergic synapse_Homo sapiens_hsa047261.68892847
21Taste transduction_Homo sapiens_hsa047421.65127563
22Parkinsons disease_Homo sapiens_hsa050121.65081791
23GnRH signaling pathway_Homo sapiens_hsa049121.64621514
24Gap junction_Homo sapiens_hsa045401.60012298
25Cardiac muscle contraction_Homo sapiens_hsa042601.59376113
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56211147
27Long-term depression_Homo sapiens_hsa047301.54504098
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.54415236
29Gastric acid secretion_Homo sapiens_hsa049711.45530445
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42592472
31Dorso-ventral axis formation_Homo sapiens_hsa043201.40115497
32Steroid biosynthesis_Homo sapiens_hsa001001.38205573
33Alzheimers disease_Homo sapiens_hsa050101.34705191
34Vibrio cholerae infection_Homo sapiens_hsa051101.34304828
35Oxytocin signaling pathway_Homo sapiens_hsa049211.32182694
36Oocyte meiosis_Homo sapiens_hsa041141.29261063
37Renin secretion_Homo sapiens_hsa049241.27568240
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24433005
39Vitamin B6 metabolism_Homo sapiens_hsa007501.22813066
40Estrogen signaling pathway_Homo sapiens_hsa049151.19524536
41Glioma_Homo sapiens_hsa052141.19032425
42Huntingtons disease_Homo sapiens_hsa050161.18555210
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16034032
44Axon guidance_Homo sapiens_hsa043601.14629594
45Calcium signaling pathway_Homo sapiens_hsa040201.07009781
46ErbB signaling pathway_Homo sapiens_hsa040121.05960339
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04997382
48Melanogenesis_Homo sapiens_hsa049161.03497476
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03367498
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01131433
51VEGF signaling pathway_Homo sapiens_hsa043700.98355869
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94374949
53Protein export_Homo sapiens_hsa030600.91943894
54Hippo signaling pathway_Homo sapiens_hsa043900.90944675
55cAMP signaling pathway_Homo sapiens_hsa040240.90155300
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.90131927
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88091345
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84284747
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83598042
60Type II diabetes mellitus_Homo sapiens_hsa049300.82471575
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81611857
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80873813
63Insulin signaling pathway_Homo sapiens_hsa049100.78751183
64Endometrial cancer_Homo sapiens_hsa052130.78370579
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78035939
66Thyroid cancer_Homo sapiens_hsa052160.76585961
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74000762
68mTOR signaling pathway_Homo sapiens_hsa041500.73784457
69Choline metabolism in cancer_Homo sapiens_hsa052310.73494639
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.73097305
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71925862
72Endocytosis_Homo sapiens_hsa041440.70049976
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.70001427
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69945211
75Alcoholism_Homo sapiens_hsa050340.68775141
76Phototransduction_Homo sapiens_hsa047440.66148828
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65956673
78MAPK signaling pathway_Homo sapiens_hsa040100.65704237
79Colorectal cancer_Homo sapiens_hsa052100.64284542
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64150901
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63058068
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.62593793
83Prion diseases_Homo sapiens_hsa050200.62013970
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60948792
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60894278
86Basal cell carcinoma_Homo sapiens_hsa052170.60894031
87Ras signaling pathway_Homo sapiens_hsa040140.59110424
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59020613
89Arginine and proline metabolism_Homo sapiens_hsa003300.58140749
90Butanoate metabolism_Homo sapiens_hsa006500.56050403
91Thyroid hormone synthesis_Homo sapiens_hsa049180.55928619
92Selenocompound metabolism_Homo sapiens_hsa004500.54892518
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53077655
94Sulfur relay system_Homo sapiens_hsa041220.52734637
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52630697
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.51351542
97Prolactin signaling pathway_Homo sapiens_hsa049170.51280132
98Pancreatic secretion_Homo sapiens_hsa049720.51269409
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51171654
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50685525
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50387156
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49775838
103Glucagon signaling pathway_Homo sapiens_hsa049220.48872985
104Pyruvate metabolism_Homo sapiens_hsa006200.48140163
105Tight junction_Homo sapiens_hsa045300.48066376
106Non-small cell lung cancer_Homo sapiens_hsa052230.47605100
107Ovarian steroidogenesis_Homo sapiens_hsa049130.46926290
108Hedgehog signaling pathway_Homo sapiens_hsa043400.44645894
109Rap1 signaling pathway_Homo sapiens_hsa040150.44327118
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43697799
111Wnt signaling pathway_Homo sapiens_hsa043100.43544406
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43421516
113Renal cell carcinoma_Homo sapiens_hsa052110.43126354
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43037599
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42904361
116Basal transcription factors_Homo sapiens_hsa030220.42782920
117mRNA surveillance pathway_Homo sapiens_hsa030150.42480409
118Melanoma_Homo sapiens_hsa052180.41836650
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41640123
120RNA polymerase_Homo sapiens_hsa030200.40740043
121Phagosome_Homo sapiens_hsa041450.40078443
122Regulation of autophagy_Homo sapiens_hsa041400.40036574
123Bile secretion_Homo sapiens_hsa049760.39837591
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39774621
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39323376
126Biosynthesis of amino acids_Homo sapiens_hsa012300.39202602
127Circadian rhythm_Homo sapiens_hsa047100.38999170
128beta-Alanine metabolism_Homo sapiens_hsa004100.38427599
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37664569
130Dilated cardiomyopathy_Homo sapiens_hsa054140.36766428
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33299945
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33188172
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32145006
134Ether lipid metabolism_Homo sapiens_hsa005650.31229360
135RNA degradation_Homo sapiens_hsa030180.28445497

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