UCHL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.98034278
2chaperone-mediated protein transport (GO:0072321)4.86948288
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.76150721
4proteasome assembly (GO:0043248)4.72224726
5ribosomal small subunit assembly (GO:0000028)4.66168919
6DNA deamination (GO:0045006)4.59648507
7DNA strand elongation involved in DNA replication (GO:0006271)4.49060227
8respiratory electron transport chain (GO:0022904)4.43050094
9telomere maintenance via semi-conservative replication (GO:0032201)4.41299073
10regulation of mitochondrial translation (GO:0070129)4.37398733
11electron transport chain (GO:0022900)4.32573762
12DNA strand elongation (GO:0022616)4.25565778
13ribosomal small subunit biogenesis (GO:0042274)4.09660341
14cullin deneddylation (GO:0010388)4.09165102
15telomere maintenance via recombination (GO:0000722)4.05206916
16establishment of integrated proviral latency (GO:0075713)4.03487974
17DNA replication initiation (GO:0006270)4.01454180
18protein complex biogenesis (GO:0070271)4.01235111
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.00660533
20formation of translation preinitiation complex (GO:0001731)4.00371954
21protein deneddylation (GO:0000338)3.95556662
22mitochondrial respiratory chain complex assembly (GO:0033108)3.94148618
23mitotic metaphase plate congression (GO:0007080)3.93959214
24CENP-A containing nucleosome assembly (GO:0034080)3.93779390
25nucleobase biosynthetic process (GO:0046112)3.93501747
26viral transcription (GO:0019083)3.92897627
27protein neddylation (GO:0045116)3.91538672
28purine nucleobase biosynthetic process (GO:0009113)3.90006580
29chromatin remodeling at centromere (GO:0031055)3.90002826
30DNA double-strand break processing (GO:0000729)3.89690249
31protein targeting to mitochondrion (GO:0006626)3.89508081
32translational termination (GO:0006415)3.88692178
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.86723676
34ribosomal large subunit biogenesis (GO:0042273)3.86700870
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.83838500
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82978147
37spliceosomal snRNP assembly (GO:0000387)3.82863511
38ribonucleoprotein complex biogenesis (GO:0022613)3.81484631
39respiratory chain complex IV assembly (GO:0008535)3.76390057
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.75714036
41NADH dehydrogenase complex assembly (GO:0010257)3.75714036
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.75714036
43mitotic recombination (GO:0006312)3.75078065
44ribosome biogenesis (GO:0042254)3.72461244
45DNA replication checkpoint (GO:0000076)3.71886887
46termination of RNA polymerase III transcription (GO:0006386)3.71259041
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.71259041
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.69234456
49negative regulation of ligase activity (GO:0051352)3.69142630
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.69142630
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.68007232
52transcription-coupled nucleotide-excision repair (GO:0006283)3.64543588
53protein localization to mitochondrion (GO:0070585)3.58393817
54translational initiation (GO:0006413)3.57357941
55DNA replication-independent nucleosome organization (GO:0034724)3.56939136
56DNA replication-independent nucleosome assembly (GO:0006336)3.56939136
57translational elongation (GO:0006414)3.56929054
58pseudouridine synthesis (GO:0001522)3.56855199
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.56260584
60telomere maintenance via telomere lengthening (GO:0010833)3.55019988
61rRNA modification (GO:0000154)3.54605410
62spliceosomal complex assembly (GO:0000245)3.53383194
63establishment of protein localization to mitochondrion (GO:0072655)3.52911306
64rRNA processing (GO:0006364)3.52800238
657-methylguanosine mRNA capping (GO:0006370)3.52205343
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50834869
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.49617620
687-methylguanosine RNA capping (GO:0009452)3.48752302
69RNA capping (GO:0036260)3.48752302
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45029956
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45029956
72regulation of ligase activity (GO:0051340)3.45019018
73regulation of cellular amino acid metabolic process (GO:0006521)3.43890832
74ribosome assembly (GO:0042255)3.43014372
75maturation of 5.8S rRNA (GO:0000460)3.42590843
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.42040483
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.42040483
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.42040483
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.41908483
80DNA replication-dependent nucleosome assembly (GO:0006335)3.41055890
81DNA replication-dependent nucleosome organization (GO:0034723)3.41055890
82rRNA metabolic process (GO:0016072)3.40411374
83establishment of protein localization to mitochondrial membrane (GO:0090151)3.39596762
84ATP synthesis coupled proton transport (GO:0015986)3.39312063
85energy coupled proton transport, down electrochemical gradient (GO:0015985)3.39312063
86metaphase plate congression (GO:0051310)3.39283677
87peptidyl-histidine modification (GO:0018202)3.38681148
88cytochrome complex assembly (GO:0017004)3.38131220
89cotranslational protein targeting to membrane (GO:0006613)3.38053628
90histone exchange (GO:0043486)3.37336692
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.37153680
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.37060022
93viral mRNA export from host cell nucleus (GO:0046784)3.36869110
94signal transduction involved in DNA damage checkpoint (GO:0072422)3.36819090
95signal transduction involved in DNA integrity checkpoint (GO:0072401)3.36819090
96signal transduction involved in cell cycle checkpoint (GO:0072395)3.33217263
97protein targeting to ER (GO:0045047)3.32979879
98translation (GO:0006412)3.32762662
99cellular component biogenesis (GO:0044085)3.28978473
100attachment of spindle microtubules to kinetochore (GO:0008608)3.28768180
101rRNA methylation (GO:0031167)3.28540735
102somatic hypermutation of immunoglobulin genes (GO:0016446)3.27677638
103somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27677638
104nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.25492567
105regulation of cellular amine metabolic process (GO:0033238)3.24933112
106kinetochore organization (GO:0051383)3.24043047
107histone mRNA metabolic process (GO:0008334)3.21947783
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.21900933
109positive regulation of ligase activity (GO:0051351)3.21276173
110G1/S transition of mitotic cell cycle (GO:0000082)3.20472642
111cell cycle G1/S phase transition (GO:0044843)3.20472642
112protein localization to endoplasmic reticulum (GO:0070972)3.19486369
113establishment of viral latency (GO:0019043)3.19084140
114L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.19067972
115DNA catabolic process, exonucleolytic (GO:0000738)3.18657167
116cellular protein complex disassembly (GO:0043624)3.17396043
117oxidative phosphorylation (GO:0006119)3.16871615
118GTP biosynthetic process (GO:0006183)3.14386743
119establishment of protein localization to endoplasmic reticulum (GO:0072599)3.14317274
120deoxyribonucleotide biosynthetic process (GO:0009263)3.13627920
121DNA unwinding involved in DNA replication (GO:0006268)3.13286750
122viral life cycle (GO:0019058)3.12606940
123transcription elongation from RNA polymerase I promoter (GO:0006362)3.11149019
124kinetochore assembly (GO:0051382)3.11019525
125establishment of chromosome localization (GO:0051303)3.10322334
126positive regulation of cell cycle arrest (GO:0071158)3.09578077
127regulation of ubiquitin-protein transferase activity (GO:0051438)3.09154407
128DNA damage response, detection of DNA damage (GO:0042769)3.08853154
129negative regulation of protein ubiquitination (GO:0031397)3.07385869
130nucleobase-containing small molecule interconversion (GO:0015949)3.04454880
131DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.03852041
132AMP metabolic process (GO:0046033)3.02621156
133pteridine-containing compound biosynthetic process (GO:0042559)3.01766461
134mitochondrial transport (GO:0006839)2.98854862
135purine nucleoside triphosphate biosynthetic process (GO:0009145)2.96839912
136water-soluble vitamin biosynthetic process (GO:0042364)2.96533020
137antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.96319035
138negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.90911196
139purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.87785840
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87485862
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87485862
142IMP biosynthetic process (GO:0006188)2.84535154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.05536708
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.67564952
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.39321312
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.87104957
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.83602739
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65146477
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.64237334
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49864316
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.42225724
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.28943429
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.15923560
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.15771266
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09213926
14MYC_19030024_ChIP-ChIP_MESCs_Mouse3.05803436
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.01629510
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98723805
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88278707
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.87984010
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.85099939
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.82140009
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65257985
22VDR_23849224_ChIP-Seq_CD4+_Human2.63664119
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58771895
24XRN2_22483619_ChIP-Seq_HELA_Human2.45808907
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43074887
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40458646
27DCP1A_22483619_ChIP-Seq_HELA_Human2.36309826
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27507266
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25820448
30* FOXP3_21729870_ChIP-Seq_TREG_Human2.16627258
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16558453
32GABP_19822575_ChIP-Seq_HepG2_Human2.09609265
33* TTF2_22483619_ChIP-Seq_HELA_Human2.07153563
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02107523
35ELK1_19687146_ChIP-ChIP_HELA_Human2.00071134
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98138589
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.95764642
38* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95527714
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95049622
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94051970
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.92255949
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87124690
43* AR_21909140_ChIP-Seq_LNCAP_Human1.86813437
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85309625
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81883155
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80017314
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76070334
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.69924211
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63848476
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59689127
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58307570
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53886241
53* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46624767
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46368077
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45891257
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43978803
57* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42176977
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40233116
59MYC_18940864_ChIP-ChIP_HL60_Human1.38558686
60CIITA_25753668_ChIP-Seq_RAJI_Human1.37520608
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29952812
62EWS_26573619_Chip-Seq_HEK293_Human1.29088927
63KDM5A_27292631_Chip-Seq_BREAST_Human1.28295533
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25594597
65FUS_26573619_Chip-Seq_HEK293_Human1.23852198
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.21849669
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20932831
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18238751
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17016311
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13085848
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10517210
72VDR_22108803_ChIP-Seq_LS180_Human1.10098588
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09165825
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08935870
75* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07689785
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07669612
77IRF1_19129219_ChIP-ChIP_H3396_Human1.07498817
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07162696
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05113180
80ZNF274_21170338_ChIP-Seq_K562_Hela1.04583626
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02333049
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01793727
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00905389
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99162964
85ELF5_23300383_ChIP-Seq_T47D_Human0.98946550
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.98824820
87KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98747116
88IGF1R_20145208_ChIP-Seq_DFB_Human0.98027312
89FLI1_27457419_Chip-Seq_LIVER_Mouse0.96596767
90STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94989513
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92866242
92NANOG_16153702_ChIP-ChIP_HESCs_Human0.89231633
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88235748
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85325002
95TFEB_21752829_ChIP-Seq_HELA_Human0.83308577
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83295686
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.82393632
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82347333
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81832396
100BP1_19119308_ChIP-ChIP_Hs578T_Human0.81351211
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81279378
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80634386
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79527353
104PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78892650
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76903085
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75475500
107POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75347378
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74765598
109TP53_22573176_ChIP-Seq_HFKS_Human0.73491182
110* SOX17_20123909_ChIP-Seq_XEN_Mouse0.73310306
111POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72738343
112SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.72368713
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72042129
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71500765
115AR_20517297_ChIP-Seq_VCAP_Human0.69875780
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.67981346
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.66528971
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.66392197
119* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.66122771
120* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.65856037
121SOX2_18692474_ChIP-Seq_MEFs_Mouse0.65640573
122ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.65598162
123NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.65309709
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.65191853
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.64780405
126SPI1_23547873_ChIP-Seq_NB4_Human0.64609308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.51507853
2MP0010094_abnormal_chromosome_stability4.95690835
3MP0004957_abnormal_blastocyst_morpholog4.88401906
4MP0003111_abnormal_nucleus_morphology4.31022803
5MP0003077_abnormal_cell_cycle4.10200236
6MP0008058_abnormal_DNA_repair3.97453355
7MP0008057_abnormal_DNA_replication3.85202872
8MP0003718_maternal_effect2.99676394
9MP0008007_abnormal_cellular_replicative2.95254508
10MP0008932_abnormal_embryonic_tissue2.94912093
11MP0008877_abnormal_DNA_methylation2.85235077
12MP0003123_paternal_imprinting2.57549851
13MP0009379_abnormal_foot_pigmentation2.50088074
14MP0003786_premature_aging2.49722045
15MP0002837_dystrophic_cardiac_calcinosis2.28821282
16MP0000372_irregular_coat_pigmentation2.22358851
17MP0003806_abnormal_nucleotide_metabolis2.19412062
18MP0001730_embryonic_growth_arrest2.08019438
19MP0001529_abnormal_vocalization2.07489723
20MP0000350_abnormal_cell_proliferation1.90742762
21MP0006292_abnormal_olfactory_placode1.81099544
22MP0002210_abnormal_sex_determination1.78682858
23MP0006036_abnormal_mitochondrial_physio1.78280409
24MP0005084_abnormal_gallbladder_morpholo1.70585608
25MP0006035_abnormal_mitochondrial_morpho1.66634354
26MP0001929_abnormal_gametogenesis1.64100750
27MP0002102_abnormal_ear_morphology1.57425301
28MP0002396_abnormal_hematopoietic_system1.56695782
29MP0001145_abnormal_male_reproductive1.52929128
30MP0003121_genomic_imprinting1.51882161
31MP0008875_abnormal_xenobiotic_pharmacok1.51248901
32MP0003315_abnormal_perineum_morphology1.50428053
33MP0001697_abnormal_embryo_size1.48747484
34MP0003186_abnormal_redox_activity1.44486243
35MP0000749_muscle_degeneration1.44192826
36MP0000653_abnormal_sex_gland1.43515314
37MP0002160_abnormal_reproductive_system1.35810856
38MP0002090_abnormal_vision1.35252326
39MP0000313_abnormal_cell_death1.33654084
40MP0002080_prenatal_lethality1.33563914
41MP0003195_calcinosis1.33256311
42MP0001672_abnormal_embryogenesis/_devel1.30367473
43MP0005380_embryogenesis_phenotype1.30367473
44* MP0006072_abnormal_retinal_apoptosis1.26537570
45MP0000490_abnormal_crypts_of1.25757701
46MP0001188_hyperpigmentation1.22513022
47MP0002019_abnormal_tumor_incidence1.22328122
48MP0004215_abnormal_myocardial_fiber1.19907424
49MP0002085_abnormal_embryonic_tissue1.19298665
50MP0005389_reproductive_system_phenotype1.18827635
51MP0005332_abnormal_amino_acid1.17357239
52MP0003890_abnormal_embryonic-extraembry1.16438948
53MP0005379_endocrine/exocrine_gland_phen1.16001795
54MP0003646_muscle_fatigue1.15820604
55MP0004133_heterotaxia1.14496512
56MP0002653_abnormal_ependyma_morphology1.10861430
57MP0003698_abnormal_male_reproductive1.10112325
58MP0003984_embryonic_growth_retardation1.09464185
59MP0005330_cardiomyopathy1.08842294
60MP0001984_abnormal_olfaction1.08617439
61MP0010386_abnormal_urinary_bladder1.05491526
62MP0002088_abnormal_embryonic_growth/wei1.05122789
63MP0000358_abnormal_cell_content/1.05026932
64MP0001119_abnormal_female_reproductive1.03066604
65MP0002084_abnormal_developmental_patter1.02515719
66MP0008789_abnormal_olfactory_epithelium1.01765639
67MP0005636_abnormal_mineral_homeostasis1.00864419
68MP0003136_yellow_coat_color1.00698127
69MP0003567_abnormal_fetal_cardiomyocyte1.00057962
70MP0001905_abnormal_dopamine_level0.99741068
71MP0001853_heart_inflammation0.99144238
72MP0003950_abnormal_plasma_membrane0.97753322
73MP0009333_abnormal_splenocyte_physiolog0.97668146
74MP0008872_abnormal_physiological_respon0.95794514
75MP0009697_abnormal_copulation0.94913068
76MP0005410_abnormal_fertilization0.94565870
77MP0002796_impaired_skin_barrier0.93234447
78MP0001293_anophthalmia0.91372423
79MP0003221_abnormal_cardiomyocyte_apopto0.90770120
80MP0001919_abnormal_reproductive_system0.89927630
81MP0005266_abnormal_metabolism0.89790102
82MP0000516_abnormal_urinary_system0.87697852
83MP0005367_renal/urinary_system_phenotyp0.87697852
84MP0002132_abnormal_respiratory_system0.87565430
85MP0001881_abnormal_mammary_gland0.87240458
86MP0002277_abnormal_respiratory_mucosa0.86793530
87MP0005646_abnormal_pituitary_gland0.84280431
88MP0002161_abnormal_fertility/fecundity0.83079490
89MP0004197_abnormal_fetal_growth/weight/0.83019123
90MP0002095_abnormal_skin_pigmentation0.82810045
91MP0003763_abnormal_thymus_physiology0.79180075
92MP0000647_abnormal_sebaceous_gland0.78191844
93MP0002086_abnormal_extraembryonic_tissu0.77525235
94MP0003941_abnormal_skin_development0.76894862
95MP0002163_abnormal_gland_morphology0.75682247
96MP0005319_abnormal_enzyme/_coenzyme0.74699875
97MP0002233_abnormal_nose_morphology0.73362985
98MP0005408_hypopigmentation0.73187426
99MP0003119_abnormal_digestive_system0.72147448
100MP0002938_white_spotting0.71385512
101MP0005501_abnormal_skin_physiology0.70273486
102MP0004808_abnormal_hematopoietic_stem0.70051431
103MP0008873_increased_physiological_sensi0.69914807
104MP0001756_abnormal_urination0.69026846
105MP0001764_abnormal_homeostasis0.68882985
106MP0001727_abnormal_embryo_implantation0.68850818
107MP0000015_abnormal_ear_pigmentation0.68833884
108MP0002398_abnormal_bone_marrow0.67892129
109MP0000689_abnormal_spleen_morphology0.67885543
110MP0000703_abnormal_thymus_morphology0.67854951
111MP0001986_abnormal_taste_sensitivity0.67533295
112MP0005395_other_phenotype0.67416831
113MP0005075_abnormal_melanosome_morpholog0.66748182
114MP0005174_abnormal_tail_pigmentation0.65932910
115MP0002751_abnormal_autonomic_nervous0.64717255
116MP0005384_cellular_phenotype0.64148061
117MP0004142_abnormal_muscle_tone0.64113730
118MP0001286_abnormal_eye_development0.63532318
119MP0008995_early_reproductive_senescence0.63423746
120MP0002722_abnormal_immune_system0.61301260
121MP0005499_abnormal_olfactory_system0.60989500
122MP0005394_taste/olfaction_phenotype0.60989500
123MP0001661_extended_life_span0.60622708
124MP0004147_increased_porphyrin_level0.60155275
125MP0002736_abnormal_nociception_after0.58766811
126MP0010030_abnormal_orbit_morphology0.58175450
127MP0003699_abnormal_female_reproductive0.56780842
128MP0002177_abnormal_outer_ear0.56735872
129MP0000049_abnormal_middle_ear0.56601000
130MP0003937_abnormal_limbs/digits/tail_de0.55904771
131MP0008004_abnormal_stomach_pH0.55627762
132MP0001485_abnormal_pinna_reflex0.55271578
133MP0002638_abnormal_pupillary_reflex0.54512501
134MP0004084_abnormal_cardiac_muscle0.54179504

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.77596776
2Abnormality of cells of the erythroid lineage (HP:0012130)4.70203423
3Abnormal number of erythroid precursors (HP:0012131)4.46539306
4Reticulocytopenia (HP:0001896)4.24349828
5Acute necrotizing encephalopathy (HP:0006965)4.16537098
6Oral leukoplakia (HP:0002745)3.97689055
7Breast hypoplasia (HP:0003187)3.86910881
8Abnormal mitochondria in muscle tissue (HP:0008316)3.76795427
9Mitochondrial inheritance (HP:0001427)3.74880425
10Aplastic anemia (HP:0001915)3.58157226
11Cerebral hypomyelination (HP:0006808)3.55692641
12Increased CSF lactate (HP:0002490)3.52886523
13Reduced antithrombin III activity (HP:0001976)3.38278001
14Increased hepatocellular lipid droplets (HP:0006565)3.34988963
15Abnormality of glycolysis (HP:0004366)3.32790614
16Increased serum pyruvate (HP:0003542)3.32790614
17Hepatocellular necrosis (HP:0001404)3.29397244
18Acute encephalopathy (HP:0006846)3.28842421
19Progressive macrocephaly (HP:0004481)3.28590900
20Carpal bone hypoplasia (HP:0001498)3.21819679
21Macrocytic anemia (HP:0001972)3.19241534
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.16059526
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.15170304
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.15170304
25Methylmalonic acidemia (HP:0002912)3.09336902
26Abnormal protein glycosylation (HP:0012346)3.08863175
27Abnormal glycosylation (HP:0012345)3.08863175
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.08863175
29Abnormal protein N-linked glycosylation (HP:0012347)3.08863175
30Increased serum lactate (HP:0002151)3.01877242
31Abnormality of methionine metabolism (HP:0010901)3.01797745
32Rough bone trabeculation (HP:0100670)2.99399116
33Patellar aplasia (HP:0006443)2.98145534
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.97192438
35Colon cancer (HP:0003003)2.92340921
36Pallor (HP:0000980)2.91773391
37Lipid accumulation in hepatocytes (HP:0006561)2.87644709
38Abnormality of the preputium (HP:0100587)2.86351078
39Chromsome breakage (HP:0040012)2.82198896
40Aplasia/Hypoplasia of the patella (HP:0006498)2.80404381
41Hepatic necrosis (HP:0002605)2.77620462
42Amniotic constriction ring (HP:0009775)2.76701378
43Abnormality of placental membranes (HP:0011409)2.76701378
44Abnormality of the anterior horn cell (HP:0006802)2.73274569
45Degeneration of anterior horn cells (HP:0002398)2.73274569
46Irregular epiphyses (HP:0010582)2.71298715
47Methylmalonic aciduria (HP:0012120)2.70393838
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69976086
49Lethargy (HP:0001254)2.66419853
50Supernumerary spleens (HP:0009799)2.57007004
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56968445
52Exercise intolerance (HP:0003546)2.56182668
533-Methylglutaconic aciduria (HP:0003535)2.50053373
54Congenital, generalized hypertrichosis (HP:0004540)2.48458981
55Premature graying of hair (HP:0002216)2.48458317
5611 pairs of ribs (HP:0000878)2.48116220
57Increased intramyocellular lipid droplets (HP:0012240)2.47722294
58Respiratory difficulties (HP:0002880)2.45106309
59Absent thumb (HP:0009777)2.44847329
60Abnormality of serum amino acid levels (HP:0003112)2.41369073
61Meckel diverticulum (HP:0002245)2.41203638
62Renal Fanconi syndrome (HP:0001994)2.40960236
63Exertional dyspnea (HP:0002875)2.40893295
64Abnormality of the labia minora (HP:0012880)2.40456579
65Optic disc pallor (HP:0000543)2.39987285
66Lactic acidosis (HP:0003128)2.39094466
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.38813628
68Abnormality of the ileum (HP:0001549)2.36288399
69Abnormality of chromosome stability (HP:0003220)2.35996016
70CNS hypomyelination (HP:0003429)2.34570578
71Pancytopenia (HP:0001876)2.31203610
72Generalized aminoaciduria (HP:0002909)2.30210665
73Microretrognathia (HP:0000308)2.28227976
74Abnormal lung lobation (HP:0002101)2.26195043
75CNS demyelination (HP:0007305)2.25825293
76Medulloblastoma (HP:0002885)2.25753813
77Horseshoe kidney (HP:0000085)2.25210113
78Type I transferrin isoform profile (HP:0003642)2.25091384
79Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24740650
80Secondary amenorrhea (HP:0000869)2.21283436
81Microvesicular hepatic steatosis (HP:0001414)2.19970543
82Absent radius (HP:0003974)2.19202000
83Bone marrow hypocellularity (HP:0005528)2.18847689
84Megaloblastic anemia (HP:0001889)2.18449732
85Agnosia (HP:0010524)2.18217472
86Aplasia/Hypoplasia of the uvula (HP:0010293)2.18089561
87Abnormality of renal resorption (HP:0011038)2.18032178
88Abnormal trabecular bone morphology (HP:0100671)2.17998335
89Respiratory failure (HP:0002878)2.16443011
90Glycosuria (HP:0003076)2.15881218
91Abnormality of urine glucose concentration (HP:0011016)2.15881218
92Type 2 muscle fiber atrophy (HP:0003554)2.15183028
93Cerebral edema (HP:0002181)2.14505472
94Premature ovarian failure (HP:0008209)2.11712861
95Selective tooth agenesis (HP:0001592)2.09824930
96Cellular immunodeficiency (HP:0005374)2.09286655
97Leukodystrophy (HP:0002415)2.09244571
98Muscle fiber atrophy (HP:0100295)2.08293825
99Palpitations (HP:0001962)2.07146523
100Myelodysplasia (HP:0002863)2.03002850
101Trismus (HP:0000211)2.02436725
102Sloping forehead (HP:0000340)2.02266694
103Absent forearm bone (HP:0003953)2.02230186
104Aplasia involving forearm bones (HP:0009822)2.02230186
105Multiple enchondromatosis (HP:0005701)2.02058292
106Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00902974
107Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00503657
108Hyperglycinemia (HP:0002154)2.00016089
109Hypoglycemic coma (HP:0001325)1.99682531
110Cleft eyelid (HP:0000625)1.99143438
111Small intestinal stenosis (HP:0012848)1.98827547
112Duodenal stenosis (HP:0100867)1.98827547
113Abnormality of vitamin B metabolism (HP:0004340)1.97632752
114X-linked dominant inheritance (HP:0001423)1.97433528
115Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96403367
116Dicarboxylic aciduria (HP:0003215)1.96403367
117Aplasia/hypoplasia of the uterus (HP:0008684)1.96230166
118Triphalangeal thumb (HP:0001199)1.95965347
119Abnormality of the vitamin B12 metabolism (HP:0004341)1.93716441
120Atrophy/Degeneration involving motor neurons (HP:0007373)1.92460906
121Neoplasm of the pancreas (HP:0002894)1.91830056
122Increased muscle lipid content (HP:0009058)1.90742234
123Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90738014
124Hypothermia (HP:0002045)1.89336483
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88393463
126Absent epiphyses (HP:0010577)1.88393463
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87552931
128Abnormality of alanine metabolism (HP:0010916)1.87552931
129Hyperalaninemia (HP:0003348)1.87552931
130Abnormal spermatogenesis (HP:0008669)1.86552276
131Glossoptosis (HP:0000162)1.86327211
132Impulsivity (HP:0100710)1.86258975
133Hyperphosphaturia (HP:0003109)1.84951616
134Sparse eyelashes (HP:0000653)1.84512154
135Poor head control (HP:0002421)1.82475758
136Congenital ichthyosiform erythroderma (HP:0007431)1.78342049
137Conjunctival hamartoma (HP:0100780)1.76455339
138Hypoplasia of the uterus (HP:0000013)1.72658107
139Median cleft lip (HP:0000161)1.71126063
140Neoplasm of the adrenal gland (HP:0100631)1.69677517
141Pancreatic cysts (HP:0001737)1.69269655
142Hyperinsulinemic hypoglycemia (HP:0000825)1.68371385
143Abnormality of sulfur amino acid metabolism (HP:0004339)1.63634204
144Pancreatic islet-cell hyperplasia (HP:0004510)1.62626077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.09027800
2WEE13.89189358
3EIF2AK13.77677529
4VRK23.68265473
5CDC73.63535833
6STK163.39490322
7SRPK13.01208393
8EIF2AK32.77199410
9VRK12.54339880
10PLK42.35956512
11NME22.26912632
12TRIM282.14731716
13TESK22.07092032
14BRSK22.02963696
15NUAK12.01946769
16MKNK12.01098439
17ACVR1B1.99189549
18NME11.96313772
19TTK1.95684789
20TSSK61.85909343
21PLK11.82885669
22PLK31.67957649
23PINK11.67587191
24NEK21.60628459
25DYRK31.57523255
26MKNK21.54735614
27CCNB11.53103305
28NEK11.47249864
29DYRK21.46838188
30AURKB1.46249259
31TLK11.45170524
32AURKA1.42721375
33MAP4K21.41043826
34MYLK1.38725891
35BRSK11.31834325
36PBK1.26562255
37ATR1.25918268
38CHEK21.23651445
39BRAF1.19472925
40PNCK1.17659249
41CDK71.13679333
42RPS6KA41.07330289
43MST41.04131081
44CSNK1A1L1.03836537
45RPS6KB21.01339579
46MUSK1.00043341
47PASK0.99851994
48MAP3K120.98935022
49BCR0.97109207
50EIF2AK20.94962041
51LIMK10.94860878
52FRK0.93962634
53TAF10.93341027
54CSNK1G20.93013686
55TESK10.92353212
56PDK30.91860891
57PDK40.91860891
58CHEK10.88860728
59EPHA20.88307250
60CDK80.86336663
61OBSCN0.84432866
62PIM20.82173296
63CSNK2A10.81132226
64OXSR10.79813373
65GRK10.79630262
66KDR0.78633115
67STK38L0.74155935
68PRKCI0.73302340
69CSNK2A20.72999250
70MAP3K80.68016054
71ADRBK20.67372095
72INSRR0.65308929
73MST1R0.65124077
74ZAK0.63954870
75MAPKAPK50.63275984
76MARK30.63154443
77PAK10.62507500
78ATM0.62230197
79STK390.59437748
80MAP3K60.58961682
81MAP3K110.58641871
82TNIK0.57211731
83CDK20.56548422
84PAK40.55197110
85RPS6KA50.54979781
86STK30.54846994
87TGFBR10.54340612
88BMPR1B0.52232997
89SCYL20.51613444
90ARAF0.51356218
91CSNK1G30.50354645
92CDK10.48441411
93STK40.48096390
94FLT30.46634508
95MAPKAPK30.45858983
96DAPK30.45455745
97DAPK10.45182943
98SIK30.45085585
99CDK40.44982641
100TIE10.44933499
101PHKG20.43078016
102PHKG10.43078016
103ILK0.43076914
104PIM10.42394718
105ERBB40.40416441
106PDK20.40300624
107PLK20.39666203
108ABL20.39338638
109CLK10.39274982
110STK240.39273147
111CASK0.39169506
112CDK190.38509172
113IRAK40.37613260
114CSNK1G10.37234635
115LATS10.35676712
116STK100.35600061
117MAP2K70.35518173
118GRK60.34799164
119CSNK1A10.31429119
120CDK30.31183204
121CSNK1E0.31157293
122LATS20.30939481
123ERBB30.30775218
124MELK0.30721158
125CDK180.30281379
126MARK10.29742825
127BCKDK0.29440502
128MAPK130.29340191
129WNK30.28575758
130YES10.27206075
131CDK11A0.27135934

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.53061678
2Proteasome_Homo sapiens_hsa030504.47163103
3Ribosome_Homo sapiens_hsa030104.17294645
4Mismatch repair_Homo sapiens_hsa034304.12333890
5RNA polymerase_Homo sapiens_hsa030203.96127826
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54344260
7Spliceosome_Homo sapiens_hsa030403.23506795
8Nucleotide excision repair_Homo sapiens_hsa034202.95005794
9RNA transport_Homo sapiens_hsa030132.87296990
10Homologous recombination_Homo sapiens_hsa034402.86015467
11Base excision repair_Homo sapiens_hsa034102.78289621
12Pyrimidine metabolism_Homo sapiens_hsa002402.76571440
13Basal transcription factors_Homo sapiens_hsa030222.37855132
14Oxidative phosphorylation_Homo sapiens_hsa001902.35549621
15Parkinsons disease_Homo sapiens_hsa050122.23250267
16Cell cycle_Homo sapiens_hsa041102.19554369
17RNA degradation_Homo sapiens_hsa030182.09798158
18Fanconi anemia pathway_Homo sapiens_hsa034602.09198185
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03981825
20One carbon pool by folate_Homo sapiens_hsa006702.01200568
21Huntingtons disease_Homo sapiens_hsa050161.95975431
22Non-homologous end-joining_Homo sapiens_hsa034501.92028521
23Purine metabolism_Homo sapiens_hsa002301.59971189
24Protein export_Homo sapiens_hsa030601.55748632
25mRNA surveillance pathway_Homo sapiens_hsa030151.40399392
26Alzheimers disease_Homo sapiens_hsa050101.35777238
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26116598
28Sulfur metabolism_Homo sapiens_hsa009201.17939861
29p53 signaling pathway_Homo sapiens_hsa041151.13611985
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08415965
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08134114
32Epstein-Barr virus infection_Homo sapiens_hsa051691.04421037
33Cysteine and methionine metabolism_Homo sapiens_hsa002700.99077812
34Oocyte meiosis_Homo sapiens_hsa041140.98685825
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92355216
36Folate biosynthesis_Homo sapiens_hsa007900.92282364
37Butanoate metabolism_Homo sapiens_hsa006500.87376357
38Steroid biosynthesis_Homo sapiens_hsa001000.82167616
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78025652
40Peroxisome_Homo sapiens_hsa041460.76127837
41Glutathione metabolism_Homo sapiens_hsa004800.75527960
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74480596
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73528215
44Systemic lupus erythematosus_Homo sapiens_hsa053220.72981920
45Caffeine metabolism_Homo sapiens_hsa002320.69235155
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68283580
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.66947200
48Biosynthesis of amino acids_Homo sapiens_hsa012300.66941275
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66513788
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66202201
51Vitamin B6 metabolism_Homo sapiens_hsa007500.65371639
52Pentose phosphate pathway_Homo sapiens_hsa000300.63959601
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63345013
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62903475
55Cardiac muscle contraction_Homo sapiens_hsa042600.62436453
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59317521
57Chemical carcinogenesis_Homo sapiens_hsa052040.59290911
58Tryptophan metabolism_Homo sapiens_hsa003800.55729555
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55104996
60Metabolic pathways_Homo sapiens_hsa011000.53780136
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53233937
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.52422007
63Sulfur relay system_Homo sapiens_hsa041220.52399616
64Nitrogen metabolism_Homo sapiens_hsa009100.50582165
65Fatty acid degradation_Homo sapiens_hsa000710.49021302
66Carbon metabolism_Homo sapiens_hsa012000.48755283
67Pyruvate metabolism_Homo sapiens_hsa006200.46796072
68beta-Alanine metabolism_Homo sapiens_hsa004100.45909231
69Primary immunodeficiency_Homo sapiens_hsa053400.43983904
70Selenocompound metabolism_Homo sapiens_hsa004500.42503193
71Antigen processing and presentation_Homo sapiens_hsa046120.42294346
72Herpes simplex infection_Homo sapiens_hsa051680.41398361
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.41134604
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40556977
75Fatty acid metabolism_Homo sapiens_hsa012120.39979797
76Viral carcinogenesis_Homo sapiens_hsa052030.39269431
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38855916
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34950970
79Phototransduction_Homo sapiens_hsa047440.34594165
80Vitamin digestion and absorption_Homo sapiens_hsa049770.33182220
81Arachidonic acid metabolism_Homo sapiens_hsa005900.32531407
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32337538
83Linoleic acid metabolism_Homo sapiens_hsa005910.30876121
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.30743315
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30365659
86Alcoholism_Homo sapiens_hsa050340.29393587
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28507245
88N-Glycan biosynthesis_Homo sapiens_hsa005100.27729022
89Fructose and mannose metabolism_Homo sapiens_hsa000510.26591410
90HTLV-I infection_Homo sapiens_hsa051660.26235089
91Retinol metabolism_Homo sapiens_hsa008300.25446095
92Tyrosine metabolism_Homo sapiens_hsa003500.25355044
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25233857
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.23573716
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22674159
96Rheumatoid arthritis_Homo sapiens_hsa053230.22453843
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21076760
98Arginine and proline metabolism_Homo sapiens_hsa003300.19598891
99Mineral absorption_Homo sapiens_hsa049780.18772216
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18707949
101Asthma_Homo sapiens_hsa053100.17915212
102Legionellosis_Homo sapiens_hsa051340.17560300
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17256636
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16131189
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15506065
106Regulation of autophagy_Homo sapiens_hsa041400.13279022
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11798215
108Shigellosis_Homo sapiens_hsa051310.11007510
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.10563348
110Thyroid cancer_Homo sapiens_hsa052160.09703940
111Allograft rejection_Homo sapiens_hsa053300.06784690
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.06022169
113Autoimmune thyroid disease_Homo sapiens_hsa053200.05898072
114Vibrio cholerae infection_Homo sapiens_hsa051100.05644930
115TGF-beta signaling pathway_Homo sapiens_hsa043500.04883461
116Fatty acid elongation_Homo sapiens_hsa000620.04726123
117Ether lipid metabolism_Homo sapiens_hsa005650.03520339
118Collecting duct acid secretion_Homo sapiens_hsa049660.02086746
119Transcriptional misregulation in cancer_Homo sapiens_hsa05202-0.0671386
120MicroRNAs in cancer_Homo sapiens_hsa05206-0.0667392
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0606679
122Type I diabetes mellitus_Homo sapiens_hsa04940-0.0572153
123Apoptosis_Homo sapiens_hsa04210-0.0385772
124Propanoate metabolism_Homo sapiens_hsa00640-0.0346123
125Hippo signaling pathway_Homo sapiens_hsa04390-0.0165673
126Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0096100
127Galactose metabolism_Homo sapiens_hsa00052-0.0091231
128Colorectal cancer_Homo sapiens_hsa05210-0.0061824

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