UCK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.19505364
2protein localization to kinetochore (GO:0034501)4.96325252
3cellular protein complex localization (GO:0034629)4.74136135
4nuclear pore organization (GO:0006999)4.63845826
5folic acid-containing compound biosynthetic process (GO:0009396)4.61653156
6nuclear pore complex assembly (GO:0051292)4.57620322
7protein complex localization (GO:0031503)4.53201518
8mitotic nuclear envelope disassembly (GO:0007077)4.31197989
9DNA replication initiation (GO:0006270)4.21347931
10formation of translation preinitiation complex (GO:0001731)4.16439219
11protein localization to chromosome, centromeric region (GO:0071459)4.14432653
12IMP biosynthetic process (GO:0006188)4.12891342
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.09049869
14DNA strand elongation involved in DNA replication (GO:0006271)4.08901664
15membrane disassembly (GO:0030397)4.04793637
16nuclear envelope disassembly (GO:0051081)4.04793637
17regulation of mitochondrial translation (GO:0070129)4.00032397
18establishment of integrated proviral latency (GO:0075713)3.91200228
19DNA strand elongation (GO:0022616)3.87457298
20DNA replication-dependent nucleosome assembly (GO:0006335)3.86605802
21DNA replication-dependent nucleosome organization (GO:0034723)3.86605802
22non-recombinational repair (GO:0000726)3.86033298
23double-strand break repair via nonhomologous end joining (GO:0006303)3.86033298
24nucleobase biosynthetic process (GO:0046112)3.81209474
25regulation of translational fidelity (GO:0006450)3.73507474
26mitotic sister chromatid segregation (GO:0000070)3.73218965
27maturation of SSU-rRNA (GO:0030490)3.69142548
28heterochromatin organization (GO:0070828)3.68401389
29IMP metabolic process (GO:0046040)3.67265097
30viral transcription (GO:0019083)3.66946629
31DNA duplex unwinding (GO:0032508)3.66536037
32mitotic metaphase plate congression (GO:0007080)3.65138624
33ribosomal small subunit assembly (GO:0000028)3.64620834
34DNA geometric change (GO:0032392)3.63821554
35sister chromatid segregation (GO:0000819)3.63734487
36translational termination (GO:0006415)3.62826099
37mitotic chromosome condensation (GO:0007076)3.55785330
38positive regulation of cell size (GO:0045793)3.55748356
39telomere maintenance via semi-conservative replication (GO:0032201)3.52602358
40DNA replication checkpoint (GO:0000076)3.49596865
41regulation of telomere maintenance via telomerase (GO:0032210)3.45597747
42negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.45502882
43translational initiation (GO:0006413)3.45323401
44pore complex assembly (GO:0046931)3.45138127
45positive regulation of chromosome segregation (GO:0051984)3.43674153
46ribosomal large subunit biogenesis (GO:0042273)3.41821793
47positive regulation of DNA-dependent DNA replication (GO:2000105)3.40982594
48L-serine metabolic process (GO:0006563)3.35993233
49translational elongation (GO:0006414)3.35323547
50regulation of spindle organization (GO:0090224)3.34408644
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33304017
52regulation of translational termination (GO:0006449)3.32273785
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.28808240
54purine nucleobase biosynthetic process (GO:0009113)3.27654358
55tRNA aminoacylation for protein translation (GO:0006418)3.27652103
56negative regulation of RNA splicing (GO:0033119)3.26845772
57transcription from mitochondrial promoter (GO:0006390)3.26526170
58dosage compensation (GO:0007549)3.25554083
59ribosome assembly (GO:0042255)3.24958499
60amino acid activation (GO:0043038)3.24579794
61tRNA aminoacylation (GO:0043039)3.24579794
62nuclear envelope organization (GO:0006998)3.24166085
63pre-miRNA processing (GO:0031054)3.23971898
64ribosome biogenesis (GO:0042254)3.23795682
65regulation of histone H3-K9 methylation (GO:0051570)3.22957142
66protein localization to chromosome (GO:0034502)3.22769514
67chromatin assembly (GO:0031497)3.21131304
68ribonucleoprotein complex biogenesis (GO:0022613)3.19692271
69regulation of posttranscriptional gene silencing (GO:0060147)3.19438704
70regulation of gene silencing by miRNA (GO:0060964)3.19438704
71regulation of gene silencing by RNA (GO:0060966)3.19438704
72viral mRNA export from host cell nucleus (GO:0046784)3.17999977
73regulation of translational elongation (GO:0006448)3.17903015
74regulation of nuclear cell cycle DNA replication (GO:0033262)3.15626913
75nucleobase-containing small molecule interconversion (GO:0015949)3.14533141
76telomere maintenance via recombination (GO:0000722)3.13176334
77negative regulation of histone methylation (GO:0031061)3.11822550
78mitotic recombination (GO:0006312)3.11764074
79ribosomal small subunit biogenesis (GO:0042274)3.11517159
80metaphase plate congression (GO:0051310)3.09891967
81positive regulation of cell cycle checkpoint (GO:1901978)3.07189441
82negative regulation of mRNA processing (GO:0050686)3.06547495
83pseudouridine synthesis (GO:0001522)3.06323180
84tetrahydrofolate metabolic process (GO:0046653)3.03363328
85peptidyl-arginine omega-N-methylation (GO:0035247)3.02606684
86maturation of 5.8S rRNA (GO:0000460)3.00115280
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.98969379
88regulation of DNA endoreduplication (GO:0032875)2.94482211
89regulation of RNA export from nucleus (GO:0046831)2.94345677
90regulation of mitotic spindle organization (GO:0060236)2.94343296
91DNA conformation change (GO:0071103)2.94249958
92mitotic sister chromatid cohesion (GO:0007064)2.94079744
93regulation of chromosome segregation (GO:0051983)2.93801562
94chromatin assembly or disassembly (GO:0006333)2.93639803
95negative regulation of mRNA metabolic process (GO:1903312)2.93088292
96pteridine-containing compound biosynthetic process (GO:0042559)2.91571849
97telomere maintenance via telomere lengthening (GO:0010833)2.91435366
98proline biosynthetic process (GO:0006561)2.91183278
99regulation of DNA-dependent DNA replication (GO:0090329)2.90872145
100cellular protein complex disassembly (GO:0043624)2.90752861
101protein targeting to ER (GO:0045047)2.90286734
102translesion synthesis (GO:0019985)2.89411858
103chromatin remodeling at centromere (GO:0031055)2.89152220
104CENP-A containing nucleosome assembly (GO:0034080)2.89048911
105rRNA modification (GO:0000154)2.88656487
106cotranslational protein targeting to membrane (GO:0006613)2.87508855
107tRNA methylation (GO:0030488)2.86792658
108rRNA processing (GO:0006364)2.86390024
109regulation of sister chromatid cohesion (GO:0007063)2.86154149
110establishment of viral latency (GO:0019043)2.84546761
111mRNA stabilization (GO:0048255)2.84158982
112RNA stabilization (GO:0043489)2.84158982
113negative regulation of chromosome segregation (GO:0051985)2.83303059
114folic acid metabolic process (GO:0046655)2.82658403
115protein complex disassembly (GO:0043241)2.82467341
116mitochondrial RNA metabolic process (GO:0000959)2.81821486
117establishment of chromosome localization (GO:0051303)2.81555138
118viral life cycle (GO:0019058)2.81500143
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.79543850
120spliceosomal tri-snRNP complex assembly (GO:0000244)2.78753331
121rRNA metabolic process (GO:0016072)2.78339465
122establishment of protein localization to endoplasmic reticulum (GO:0072599)2.78097564
123positive regulation of mitotic sister chromatid separation (GO:1901970)2.77610382
124positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.77610382
125positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.77610382
126kinetochore organization (GO:0051383)2.76833503
127mRNA splicing, via spliceosome (GO:0000398)2.75666352
128RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.75666352
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.75457781
130somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75457781
131RNA splicing, via transesterification reactions (GO:0000375)2.75272922
132spindle checkpoint (GO:0031577)2.74483966
133histone arginine methylation (GO:0034969)2.73894358
134spindle assembly checkpoint (GO:0071173)2.73824149
135DNA topological change (GO:0006265)2.73419285
136spliceosomal snRNP assembly (GO:0000387)2.71121011
137G1/S transition of mitotic cell cycle (GO:0000082)2.70969523
138cell cycle G1/S phase transition (GO:0044843)2.70969523
139folic acid-containing compound metabolic process (GO:0006760)2.68545748
140ncRNA 3-end processing (GO:0043628)2.68386779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.91722493
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.66281298
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.96395592
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53368083
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51719101
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03588701
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02280010
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.97243588
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57482673
10MYC_22102868_ChIP-Seq_BL_Human2.55825325
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36961494
12XRN2_22483619_ChIP-Seq_HELA_Human2.16917428
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09745096
14AR_21909140_ChIP-Seq_LNCAP_Human2.04002096
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.02489777
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02273894
17E2F1_21310950_ChIP-Seq_MCF-7_Human1.99066233
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98781876
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.95715249
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87519871
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86865794
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79113061
23* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75836697
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71316297
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69419833
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68596463
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67280442
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.65886014
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65220681
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64201873
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63415482
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63177458
33VDR_23849224_ChIP-Seq_CD4+_Human1.63084275
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62442884
35TTF2_22483619_ChIP-Seq_HELA_Human1.58208887
36CIITA_25753668_ChIP-Seq_RAJI_Human1.58110196
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58007112
38VDR_21846776_ChIP-Seq_THP-1_Human1.54739682
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54121880
40FOXP3_21729870_ChIP-Seq_TREG_Human1.53934446
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53872454
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52367397
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51344776
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.51235881
45GABP_19822575_ChIP-Seq_HepG2_Human1.50523561
46DCP1A_22483619_ChIP-Seq_HELA_Human1.49426819
47* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44205990
48* KDM5A_27292631_Chip-Seq_BREAST_Human1.43797436
49KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42266242
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38926897
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38902100
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35772941
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35491067
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35296302
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35155662
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34205516
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32255807
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32006391
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31881289
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31830536
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31573773
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26500826
63* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25968685
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.23292198
65ELK1_19687146_ChIP-ChIP_HELA_Human1.20638299
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18843151
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18389364
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17068980
69* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16855888
70TFEB_21752829_ChIP-Seq_HELA_Human1.16624210
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14359804
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13179276
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13179276
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13179276
75* MYC_18940864_ChIP-ChIP_HL60_Human1.11614736
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11543017
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10930694
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.10468376
79* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10127504
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08738774
81* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08723604
82* SOX17_20123909_ChIP-Seq_XEN_Mouse1.08278483
83* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07962890
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.07225018
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07011679
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06694700
87TCF7_22412390_ChIP-Seq_EML_Mouse1.05546314
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04625479
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02033462
90ZNF263_19887448_ChIP-Seq_K562_Human1.01835135
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01792903
92* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01659108
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.01478115
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98908177
95* UTX_26944678_Chip-Seq_JUKART_Human0.98421880
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96719552
97ATF3_27146783_Chip-Seq_COLON_Human0.96127193
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95113840
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.95049531
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94942445
101FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94289269
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94090685
103CHD1_26751641_Chip-Seq_LNCaP_Human0.93200226
104* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89564690
105MAF_26560356_Chip-Seq_TH1_Human0.89209519
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88087543
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87739430
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87444649
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.87225248
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86945960
111* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86182886
112SALL1_21062744_ChIP-ChIP_HESCs_Human0.86062033
113HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85911700
114* KDM2B_26808549_Chip-Seq_DND41_Human0.85375939
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84350789
116* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84161741
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83865575
118* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83769266
119TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80826406
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80698941
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78436803
122NANOG_16153702_ChIP-ChIP_HESCs_Human0.76481030
123* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76011251
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75316011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.23947802
2MP0003111_abnormal_nucleus_morphology3.97042693
3MP0004957_abnormal_blastocyst_morpholog3.82260137
4MP0010094_abnormal_chromosome_stability3.79288341
5MP0010352_gastrointestinal_tract_polyps3.68197143
6MP0003077_abnormal_cell_cycle3.39030494
7MP0008057_abnormal_DNA_replication3.16990628
8MP0000566_synostosis2.94081954
9MP0001730_embryonic_growth_arrest2.52646213
10MP0002396_abnormal_hematopoietic_system2.38194456
11MP0008007_abnormal_cellular_replicative2.30501825
12MP0000350_abnormal_cell_proliferation2.28535704
13MP0002234_abnormal_pharynx_morphology2.24741781
14MP0008058_abnormal_DNA_repair2.24502575
15MP0010307_abnormal_tumor_latency2.20533869
16MP0005076_abnormal_cell_differentiation2.19281719
17MP0003705_abnormal_hypodermis_morpholog2.18986877
18MP0008932_abnormal_embryonic_tissue2.12407868
19MP0003123_paternal_imprinting2.08193675
20MP0005380_embryogenesis_phenotype1.97152435
21MP0001672_abnormal_embryogenesis/_devel1.97152435
22MP0001697_abnormal_embryo_size1.85577382
23MP0004197_abnormal_fetal_growth/weight/1.84822814
24MP0002084_abnormal_developmental_patter1.84281931
25MP0003984_embryonic_growth_retardation1.81942699
26MP0002085_abnormal_embryonic_tissue1.79876009
27MP0000490_abnormal_crypts_of1.79816963
28MP0002088_abnormal_embryonic_growth/wei1.78693228
29MP0002086_abnormal_extraembryonic_tissu1.72834555
30MP0002080_prenatal_lethality1.71075974
31MP0010030_abnormal_orbit_morphology1.65963018
32MP0002877_abnormal_melanocyte_morpholog1.61595880
33MP0009278_abnormal_bone_marrow1.58581532
34MP0004808_abnormal_hematopoietic_stem1.57110161
35MP0009697_abnormal_copulation1.56120578
36MP0004858_abnormal_nervous_system1.53787933
37MP0003567_abnormal_fetal_cardiomyocyte1.38456727
38MP0003890_abnormal_embryonic-extraembry1.37342475
39MP0000537_abnormal_urethra_morphology1.35483384
40MP0000467_abnormal_esophagus_morphology1.34096518
41MP0000313_abnormal_cell_death1.33348028
42MP0003119_abnormal_digestive_system1.32362020
43MP0003566_abnormal_cell_adhesion1.32269497
44MP0002019_abnormal_tumor_incidence1.32153773
45MP0003786_premature_aging1.31853346
46MP0000703_abnormal_thymus_morphology1.26666696
47MP0003646_muscle_fatigue1.24982171
48MP0001661_extended_life_span1.23843622
49MP0009053_abnormal_anal_canal1.21501367
50MP0005397_hematopoietic_system_phenotyp1.20790569
51MP0001545_abnormal_hematopoietic_system1.20790569
52MP0001293_anophthalmia1.20744417
53MP0003315_abnormal_perineum_morphology1.18888425
54MP0001849_ear_inflammation1.16792888
55MP0003121_genomic_imprinting1.15586472
56MP0002233_abnormal_nose_morphology1.15092838
57MP0010368_abnormal_lymphatic_system1.14295617
58MP0003303_peritoneal_inflammation1.14086463
59MP0009333_abnormal_splenocyte_physiolog1.14026943
60MP0008877_abnormal_DNA_methylation1.12119133
61MP0000733_abnormal_muscle_development1.11402527
62MP0000428_abnormal_craniofacial_morphol1.09734571
63MP0000579_abnormal_nail_morphology1.09733739
64MP0005023_abnormal_wound_healing1.09110438
65MP0003763_abnormal_thymus_physiology1.06929130
66MP0002796_impaired_skin_barrier1.01999728
67MP0005645_abnormal_hypothalamus_physiol1.00741693
68MP0009672_abnormal_birth_weight0.99658639
69MP0000762_abnormal_tongue_morphology0.99652373
70MP0002060_abnormal_skin_morphology0.98290649
71MP0002111_abnormal_tail_morphology0.96756572
72MP0002009_preneoplasia0.96711504
73MP0002938_white_spotting0.95865623
74MP0004264_abnormal_extraembryonic_tissu0.94079542
75MP0001915_intracranial_hemorrhage0.91761278
76MP0002653_abnormal_ependyma_morphology0.91412984
77MP0000858_altered_metastatic_potential0.90194434
78MP0006035_abnormal_mitochondrial_morpho0.90125522
79MP0002398_abnormal_bone_marrow0.89424802
80MP0002722_abnormal_immune_system0.87956434
81MP0003755_abnormal_palate_morphology0.87663521
82MP0003942_abnormal_urinary_system0.87038303
83MP0003283_abnormal_digestive_organ0.85518586
84MP0004233_abnormal_muscle_weight0.84967277
85MP0009703_decreased_birth_body0.83977827
86MP0006054_spinal_hemorrhage0.83736517
87MP0001346_abnormal_lacrimal_gland0.83735098
88MP0003300_gastrointestinal_ulcer0.83596593
89MP0003937_abnormal_limbs/digits/tail_de0.83308604
90MP0002163_abnormal_gland_morphology0.83236647
91MP0002925_abnormal_cardiovascular_devel0.83057347
92MP0005621_abnormal_cell_physiology0.82840560
93MP0002092_abnormal_eye_morphology0.82382811
94MP0008770_decreased_survivor_rate0.81477897
95MP0003221_abnormal_cardiomyocyte_apopto0.80456536
96MP0003935_abnormal_craniofacial_develop0.79612110
97MP0005384_cellular_phenotype0.79045610
98MP0003385_abnormal_body_wall0.78899520
99MP0000358_abnormal_cell_content/0.78150789
100MP0000477_abnormal_intestine_morphology0.77777379
101MP0005257_abnormal_intraocular_pressure0.75066211
102MP0005187_abnormal_penis_morphology0.74400375
103MP0003115_abnormal_respiratory_system0.73942236
104MP0004185_abnormal_adipocyte_glucose0.73894105
105MP0000432_abnormal_head_morphology0.73865164
106MP0002697_abnormal_eye_size0.73789199
107MP0004272_abnormal_basement_membrane0.73683952
108MP0005623_abnormal_meninges_morphology0.73545632
109MP0010678_abnormal_skin_adnexa0.72765699
110MP0009250_abnormal_appendicular_skeleto0.72434897
111MP0002116_abnormal_craniofacial_bone0.71927146
112MP0005197_abnormal_uvea_morphology0.71767365
113MP0002210_abnormal_sex_determination0.71648935
114MP0001145_abnormal_male_reproductive0.69770148
115MP0000750_abnormal_muscle_regeneration0.69712070
116MP0000678_abnormal_parathyroid_gland0.69686005
117MP0010234_abnormal_vibrissa_follicle0.69182236
118MP0000689_abnormal_spleen_morphology0.69164172
119MP0000372_irregular_coat_pigmentation0.68131665
120MP0000627_abnormal_mammary_gland0.67659296
121MP0001919_abnormal_reproductive_system0.67294929
122MP0003806_abnormal_nucleotide_metabolis0.67162426
123MP0003448_altered_tumor_morphology0.64344974
124MP0001286_abnormal_eye_development0.63134365
125MP0002429_abnormal_blood_cell0.62439492
126MP0001348_abnormal_lacrimal_gland0.62032617
127MP0005501_abnormal_skin_physiology0.61358680
128MP0000266_abnormal_heart_morphology0.59998702
129MP0003861_abnormal_nervous_system0.58923710
130MP0004133_heterotaxia0.58874534
131MP0002932_abnormal_joint_morphology0.58730849
132MP0000377_abnormal_hair_follicle0.58568165
133MP0003941_abnormal_skin_development0.58496295
134MP0003718_maternal_effect0.57347981
135MP0002114_abnormal_axial_skeleton0.57235752

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.72125855
2Colon cancer (HP:0003003)3.55488041
3Reticulocytopenia (HP:0001896)3.38130060
4Medulloblastoma (HP:0002885)3.22699109
5Astrocytoma (HP:0009592)3.21051228
6Abnormality of the astrocytes (HP:0100707)3.21051228
7Selective tooth agenesis (HP:0001592)3.19084097
8Abnormality of cells of the erythroid lineage (HP:0012130)3.09735791
9Birth length less than 3rd percentile (HP:0003561)3.07198591
10Lip pit (HP:0100267)2.95363960
11Anal stenosis (HP:0002025)2.93090669
12Abnormal number of erythroid precursors (HP:0012131)2.85032791
13Microvesicular hepatic steatosis (HP:0001414)2.81798191
14Facial cleft (HP:0002006)2.77151984
15Chromsome breakage (HP:0040012)2.70929140
16Deviation of the thumb (HP:0009603)2.62670752
17Glioma (HP:0009733)2.60719007
18Proximal placement of thumb (HP:0009623)2.59264306
19Intestinal fistula (HP:0100819)2.58580071
20Rhabdomyosarcoma (HP:0002859)2.58159697
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56729916
22Patellar aplasia (HP:0006443)2.56110580
23Short 5th finger (HP:0009237)2.54428711
24Increased nuchal translucency (HP:0010880)2.54042877
25Neoplasm of the oral cavity (HP:0100649)2.50496494
26Basal cell carcinoma (HP:0002671)2.47799133
27Abnormality of the anterior horn cell (HP:0006802)2.45555924
28Degeneration of anterior horn cells (HP:0002398)2.45555924
29Breast hypoplasia (HP:0003187)2.42192065
30Septate vagina (HP:0001153)2.41101152
31Aplasia/Hypoplasia of the patella (HP:0006498)2.39937942
32Atresia of the external auditory canal (HP:0000413)2.37205013
33Carpal bone hypoplasia (HP:0001498)2.37089363
34Depressed nasal tip (HP:0000437)2.36369029
35Facial hemangioma (HP:0000329)2.34901878
36Missing ribs (HP:0000921)2.33908384
37Progressive muscle weakness (HP:0003323)2.30564501
38Popliteal pterygium (HP:0009756)2.27080741
39Abnormality of the labia minora (HP:0012880)2.26368286
40Trismus (HP:0000211)2.25896261
41Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.24246499
42Multiple enchondromatosis (HP:0005701)2.21933435
43Natal tooth (HP:0000695)2.21770858
44Myelodysplasia (HP:0002863)2.20517567
45Pterygium (HP:0001059)2.20365385
46Neoplasm of the pancreas (HP:0002894)2.19500284
47Hyperacusis (HP:0010780)2.18358147
48Absent thumb (HP:0009777)2.16630883
49Neoplasm of striated muscle (HP:0009728)2.16143907
50Asymmetry of the thorax (HP:0001555)2.15904579
51Abnormal number of incisors (HP:0011064)2.14654549
52Abnormality of glycolysis (HP:0004366)2.14557558
53Abnormality of chromosome stability (HP:0003220)2.13228633
54Posterior subcapsular cataract (HP:0007787)2.12109436
55Long palpebral fissure (HP:0000637)2.10722453
56High pitched voice (HP:0001620)2.10229682
57Abnormality of the umbilical cord (HP:0010881)2.09816886
58Overlapping toe (HP:0001845)2.08081725
59Absent radius (HP:0003974)2.07016199
60Increased density of long bones (HP:0006392)2.06883303
61Abnormality of the distal phalanges of the toes (HP:0010182)2.06797662
62Prominent nose (HP:0000448)2.06628269
63Difficulty climbing stairs (HP:0003551)2.06426211
64Volvulus (HP:0002580)2.06345286
65Adenoma sebaceum (HP:0009720)2.05865694
66Angiofibromas (HP:0010615)2.05865694
67High anterior hairline (HP:0009890)2.05731465
68Abnormality of the calcaneus (HP:0008364)2.05083080
69Abnormality of cochlea (HP:0000375)2.04766721
70Agnosia (HP:0010524)2.04600391
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03697363
72Short 4th metacarpal (HP:0010044)2.03697363
73Meckel diverticulum (HP:0002245)2.03112528
74Cafe-au-lait spot (HP:0000957)2.01696440
75Renal duplication (HP:0000075)2.01318333
76Oral leukoplakia (HP:0002745)1.99299027
77Biliary tract neoplasm (HP:0100574)1.99097243
78Abnormality of the ileum (HP:0001549)1.98980390
79Ectopic kidney (HP:0000086)1.98551763
80Impulsivity (HP:0100710)1.96484614
81Aplasia/Hypoplasia of the uvula (HP:0010293)1.95982746
82Squamous cell carcinoma (HP:0002860)1.95978381
83Gastrointestinal carcinoma (HP:0002672)1.93926092
84Malignant gastrointestinal tract tumors (HP:0006749)1.93926092
85Abnormalities of placenta or umbilical cord (HP:0001194)1.93140018
86Aplasia/hypoplasia of the humerus (HP:0006507)1.92486901
87Amaurosis fugax (HP:0100576)1.91714997
88Pallor (HP:0000980)1.89911624
89Abnormality of methionine metabolism (HP:0010901)1.89082230
90Absent forearm bone (HP:0003953)1.88946908
91Aplasia involving forearm bones (HP:0009822)1.88946908
92Genu recurvatum (HP:0002816)1.88400977
93Reduced subcutaneous adipose tissue (HP:0003758)1.87619680
9411 pairs of ribs (HP:0000878)1.86207395
95Abnormality of placental membranes (HP:0011409)1.85504240
96Amniotic constriction ring (HP:0009775)1.85504240
97Abnormality of the preputium (HP:0100587)1.85443292
98Skin tags (HP:0010609)1.83723763
99Progressive external ophthalmoplegia (HP:0000590)1.81409476
100Subacute progressive viral hepatitis (HP:0006572)1.81333333
101Protrusio acetabuli (HP:0003179)1.80820855
102Rough bone trabeculation (HP:0100670)1.80754375
103Rib fusion (HP:0000902)1.80512974
104Small intestinal stenosis (HP:0012848)1.79564629
105Duodenal stenosis (HP:0100867)1.79564629
106Macrocytic anemia (HP:0001972)1.79504135
107Tracheoesophageal fistula (HP:0002575)1.79138981
108Preauricular skin tag (HP:0000384)1.78819245
109Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78760941
110Broad palm (HP:0001169)1.77001600
111Short humerus (HP:0005792)1.76461120
112Cortical dysplasia (HP:0002539)1.76166529
113Slender long bone (HP:0003100)1.75880175
114Megalocornea (HP:0000485)1.75132371
115Cutaneous melanoma (HP:0012056)1.74603879
116Thrombocytosis (HP:0001894)1.74553222
117Glossoptosis (HP:0000162)1.74494273
118Ureteral stenosis (HP:0000071)1.74018856
119Aplastic anemia (HP:0001915)1.72698793
120Pelvic girdle muscle weakness (HP:0003749)1.72275342
121Abnormality of the fetal cardiovascular system (HP:0010948)1.71580387
122Abnormal umbilical cord blood vessels (HP:0011403)1.71580387
123Single umbilical artery (HP:0001195)1.71580387
124Horseshoe kidney (HP:0000085)1.71224106
125Spinal muscular atrophy (HP:0007269)1.70405055
126Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69782126
127Fibular aplasia (HP:0002990)1.69352610
128Sensory axonal neuropathy (HP:0003390)1.69330852
129Intestinal polyp (HP:0005266)1.69174583
130Bowel diverticulosis (HP:0005222)1.66972522
131Fibroma (HP:0010614)1.66431631
132Premature graying of hair (HP:0002216)1.66332110
133Choanal atresia (HP:0000453)1.66243326
134Sparse lateral eyebrow (HP:0005338)1.66026623
135Long eyelashes (HP:0000527)1.65732124
136Abnormality of the fingertips (HP:0001211)1.65605510
137Neoplasm of the colon (HP:0100273)1.65589383
138Increased serum pyruvate (HP:0003542)1.65561787
139Abnormality of the carotid arteries (HP:0005344)1.65025095
140Spastic diplegia (HP:0001264)1.64771187
141Secondary amenorrhea (HP:0000869)1.64045037
142Shoulder girdle muscle weakness (HP:0003547)1.63417859
143Abnormality of alanine metabolism (HP:0010916)1.61622726
144Hyperalaninemia (HP:0003348)1.61622726
145Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61622726
146Abnormality of the duodenum (HP:0002246)1.61530347
147Sparse eyelashes (HP:0000653)1.60474655
148Abnormality of subcutaneous fat tissue (HP:0001001)1.59324332
149Self-mutilation (HP:0000742)1.59266350
150Megaloblastic anemia (HP:0001889)1.57125896
151Nephroblastoma (Wilms tumor) (HP:0002667)1.54713050
152Premature ovarian failure (HP:0008209)1.54021508
153Ureteral obstruction (HP:0006000)1.53805596
154Dysmetric saccades (HP:0000641)1.52858691
155Premature rupture of membranes (HP:0001788)1.52818854
156Advanced eruption of teeth (HP:0006288)1.52711167
157Hypokinesia (HP:0002375)1.51542617
158Neuroectodermal neoplasm (HP:0030061)1.50966555
159Neuroepithelial neoplasm (HP:0030063)1.50966555
160Nervous tissue neoplasm (HP:0030060)1.50966555
161Testicular atrophy (HP:0000029)1.50121508

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.15186519
2CDC73.81672285
3CDK123.11797400
4PBK3.00094211
5WEE12.98638863
6BUB12.86283635
7PKN22.85833269
8NEK22.81189840
9STK242.78378989
10RPS6KB22.44481988
11MAP3K102.36342441
12CCNB12.29572933
13TRIB32.27250117
14VRK22.25990853
15PASK2.21927465
16TTK2.19687958
17SMG12.11757997
18TSSK61.91596589
19SCYL21.88940726
20EPHA21.77231579
21NEK11.76885352
22STK101.70857376
23EIF2AK11.67735168
24IRAK31.66954384
25CDK71.65392666
26NME21.64759148
27TESK21.64098002
28STK161.60018792
29MAP3K81.55184147
30SRPK11.54086783
31CDK41.53399662
32PLK11.52944877
33STK391.51650465
34ALK1.49827948
35MST1R1.49275314
36ATR1.41405150
37AURKB1.40591236
38FLT31.40309355
39WNK41.39922160
40CHEK21.29905996
41BRSK21.29642516
42CHEK11.27828409
43RPS6KA41.26028897
44PAK41.25129947
45TAF11.19785373
46DYRK31.17554694
47LRRK21.16480455
48MKNK11.14611718
49TLK11.10025988
50MTOR1.09027128
51TGFBR11.07993054
52CDK81.07082816
53PIM11.05525976
54EIF2AK21.02732301
55STK30.99916897
56ACVR1B0.99370933
57AURKA0.98654427
58BRD40.97785418
59MAPKAPK30.97338550
60PLK30.96184875
61STK40.95816461
62LATS20.93289933
63CDK60.91391639
64EIF2AK30.90936616
65CDK20.90855162
66PDK20.88726551
67MET0.87941789
68MAP4K10.87682249
69PDGFRA0.86175757
70MKNK20.85516532
71ERBB40.84598441
72ATM0.83547577
73PAK20.83252059
74ICK0.82369922
75TTN0.81991986
76GRK60.77991832
77NME10.76898971
78PTK60.76521614
79LATS10.76385720
80BRSK10.75646266
81TRIM280.73506270
82MAPKAPK50.72384429
83TESK10.71327247
84PLK40.66212051
85PAK10.65582437
86CAMK1G0.65356283
87BMX0.65020627
88PIM20.63052668
89CAMK1D0.61164336
90MAP2K30.60760336
91CDK10.60687855
92AKT20.58551557
93ZAP700.57783962
94PTK20.55803762
95FGFR10.55787351
96CSNK1G30.55513492
97MAP3K20.54691375
98MELK0.54536790
99VRK10.51825326
100MAP3K110.51563510
101ILK0.51269392
102PRKCI0.50763015
103CSNK2A20.50203107
104DAPK10.49889685
105CSNK1A1L0.49320740
106BRAF0.47954524
107CSNK1G10.47719735
108CSNK1E0.45805958
109PNCK0.43741504
110TAOK10.40133141
111PRKDC0.37825219
112CSNK1D0.37239161
113DDR20.36422389
114TYRO30.35292370
115MST40.35011811
116PDGFRB0.34854183
117CLK10.34115251
118MAPK140.32975429
119MAPK110.32974766
120HIPK20.32612400
121RPS6KA10.32601905
122MAP3K30.32545726
123ERN10.32299596
124CSNK2A10.31886644
125CDK90.31316131
126JAK30.30917936
127ZAK0.30753990
128AKT10.29905827
129ERBB30.29641847
130MAPKAPK20.29203872
131CDK180.29065874
132MAPK10.27950350
133CDK150.27919967
134CDK11A0.27566396

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35734949
2Mismatch repair_Homo sapiens_hsa034303.59703170
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32462204
4RNA transport_Homo sapiens_hsa030133.19833861
5Spliceosome_Homo sapiens_hsa030403.08205516
6One carbon pool by folate_Homo sapiens_hsa006702.88955727
7Ribosome_Homo sapiens_hsa030102.84125215
8Cell cycle_Homo sapiens_hsa041102.80398494
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.72826685
10Base excision repair_Homo sapiens_hsa034102.63348158
11Nucleotide excision repair_Homo sapiens_hsa034202.27630206
12Homologous recombination_Homo sapiens_hsa034402.19231488
13RNA polymerase_Homo sapiens_hsa030202.10534193
14mRNA surveillance pathway_Homo sapiens_hsa030152.02071384
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93862161
16Non-homologous end-joining_Homo sapiens_hsa034501.82563277
17Vitamin B6 metabolism_Homo sapiens_hsa007501.77098784
18Fanconi anemia pathway_Homo sapiens_hsa034601.73871258
19p53 signaling pathway_Homo sapiens_hsa041151.73462429
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61443459
21RNA degradation_Homo sapiens_hsa030181.60420390
22* Pyrimidine metabolism_Homo sapiens_hsa002401.57841537
23Arginine biosynthesis_Homo sapiens_hsa002201.46901443
24Proteasome_Homo sapiens_hsa030501.46427621
25Pyruvate metabolism_Homo sapiens_hsa006201.44715588
26Viral carcinogenesis_Homo sapiens_hsa052031.38107392
27MicroRNAs in cancer_Homo sapiens_hsa052061.30711889
28Systemic lupus erythematosus_Homo sapiens_hsa053221.29554977
29Basal transcription factors_Homo sapiens_hsa030221.26788446
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15986443
31Chronic myeloid leukemia_Homo sapiens_hsa052201.15114291
32Epstein-Barr virus infection_Homo sapiens_hsa051691.13745679
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13503044
34Thyroid cancer_Homo sapiens_hsa052161.11022984
35HTLV-I infection_Homo sapiens_hsa051661.10903518
36Selenocompound metabolism_Homo sapiens_hsa004501.08406343
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08011604
38Small cell lung cancer_Homo sapiens_hsa052221.07295086
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04145293
40Colorectal cancer_Homo sapiens_hsa052101.01954866
41Antigen processing and presentation_Homo sapiens_hsa046121.00239247
42Protein export_Homo sapiens_hsa030600.99647893
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96890000
44Oocyte meiosis_Homo sapiens_hsa041140.94995084
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.93716947
46Hippo signaling pathway_Homo sapiens_hsa043900.93437085
47mTOR signaling pathway_Homo sapiens_hsa041500.92191772
48Herpes simplex infection_Homo sapiens_hsa051680.91205855
49Basal cell carcinoma_Homo sapiens_hsa052170.91193172
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.90915910
51Biosynthesis of amino acids_Homo sapiens_hsa012300.87447307
52Folate biosynthesis_Homo sapiens_hsa007900.87319807
53Bladder cancer_Homo sapiens_hsa052190.87037848
54Acute myeloid leukemia_Homo sapiens_hsa052210.86788977
55Fatty acid elongation_Homo sapiens_hsa000620.86440586
56Notch signaling pathway_Homo sapiens_hsa043300.85134885
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84357504
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83959374
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81123682
60Pentose phosphate pathway_Homo sapiens_hsa000300.81065711
61Purine metabolism_Homo sapiens_hsa002300.77963047
62Fructose and mannose metabolism_Homo sapiens_hsa000510.76255799
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74819073
64Apoptosis_Homo sapiens_hsa042100.74089580
65Adherens junction_Homo sapiens_hsa045200.73048883
66Endometrial cancer_Homo sapiens_hsa052130.72677724
67Arginine and proline metabolism_Homo sapiens_hsa003300.72499283
68TGF-beta signaling pathway_Homo sapiens_hsa043500.71194339
69Legionellosis_Homo sapiens_hsa051340.70893618
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70055099
71Viral myocarditis_Homo sapiens_hsa054160.69988911
72Non-small cell lung cancer_Homo sapiens_hsa052230.67639303
73Hepatitis B_Homo sapiens_hsa051610.67329716
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67020685
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64542864
76Huntingtons disease_Homo sapiens_hsa050160.62515087
77Proteoglycans in cancer_Homo sapiens_hsa052050.62406220
78HIF-1 signaling pathway_Homo sapiens_hsa040660.61455252
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60721450
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60273872
81Alcoholism_Homo sapiens_hsa050340.59608691
82N-Glycan biosynthesis_Homo sapiens_hsa005100.55722713
83Shigellosis_Homo sapiens_hsa051310.55460341
84Pathways in cancer_Homo sapiens_hsa052000.55409173
85Hedgehog signaling pathway_Homo sapiens_hsa043400.55299604
86Pancreatic cancer_Homo sapiens_hsa052120.55159712
87Prostate cancer_Homo sapiens_hsa052150.54524683
88Steroid biosynthesis_Homo sapiens_hsa001000.52132289
89Primary immunodeficiency_Homo sapiens_hsa053400.51937436
90Measles_Homo sapiens_hsa051620.51023017
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50186392
92Parkinsons disease_Homo sapiens_hsa050120.49621773
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48003897
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47683346
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46955759
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46629089
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45856858
98VEGF signaling pathway_Homo sapiens_hsa043700.45762762
99Propanoate metabolism_Homo sapiens_hsa006400.45468126
100Sulfur relay system_Homo sapiens_hsa041220.45267423
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.44761017
102* Metabolic pathways_Homo sapiens_hsa011000.44398268
103Lysine degradation_Homo sapiens_hsa003100.44214877
104AMPK signaling pathway_Homo sapiens_hsa041520.43165066
105Wnt signaling pathway_Homo sapiens_hsa043100.42662576
106Sulfur metabolism_Homo sapiens_hsa009200.42486920
107T cell receptor signaling pathway_Homo sapiens_hsa046600.41727967
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.41034379
109Tight junction_Homo sapiens_hsa045300.40056226
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39668399
111Focal adhesion_Homo sapiens_hsa045100.39628009
112Glutathione metabolism_Homo sapiens_hsa004800.39561995
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38940129
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.38647615
115* Drug metabolism - other enzymes_Homo sapiens_hsa009830.38640121
116Fatty acid metabolism_Homo sapiens_hsa012120.37427955
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.36954902
118Melanoma_Homo sapiens_hsa052180.35423216
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35333648
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35182933
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33667847
122Toxoplasmosis_Homo sapiens_hsa051450.32678462
123Galactose metabolism_Homo sapiens_hsa000520.32334752
124Renal cell carcinoma_Homo sapiens_hsa052110.32032950
125Carbon metabolism_Homo sapiens_hsa012000.31909250
126FoxO signaling pathway_Homo sapiens_hsa040680.31701139
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31638794
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31170535
129Oxidative phosphorylation_Homo sapiens_hsa001900.30520037
130Glioma_Homo sapiens_hsa052140.28648880
131Influenza A_Homo sapiens_hsa051640.28304063
132Vitamin digestion and absorption_Homo sapiens_hsa049770.26970016
133Prolactin signaling pathway_Homo sapiens_hsa049170.26952825
134Alzheimers disease_Homo sapiens_hsa050100.25142339
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21392604
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20420198
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17075849
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16468532

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