UCN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.39020708
2desmosome organization (GO:0002934)6.42838913
3regulation of plasminogen activation (GO:0010755)5.47056258
4positive regulation of natural killer cell differentiation (GO:0032825)5.02076520
5superoxide anion generation (GO:0042554)4.92767842
6endodermal cell differentiation (GO:0035987)4.82847256
7skin morphogenesis (GO:0043589)4.80709362
8Golgi transport vesicle coating (GO:0048200)4.77075921
9COPI coating of Golgi vesicle (GO:0048205)4.77075921
10melanin biosynthetic process (GO:0042438)4.63625410
11cell-substrate junction assembly (GO:0007044)4.62311565
12cell adhesion mediated by integrin (GO:0033627)4.59783100
13protein localization to endosome (GO:0036010)4.43610129
14negative regulation of chondrocyte differentiation (GO:0032331)4.40831971
15protein maturation by protein folding (GO:0022417)4.38657938
16peptidyl-proline hydroxylation (GO:0019511)4.34840636
17basement membrane organization (GO:0071711)4.34457922
18protein retention in ER lumen (GO:0006621)4.29549354
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.26964689
20mesodermal cell differentiation (GO:0048333)4.14084174
21hypotonic response (GO:0006971)4.11872531
22protein hydroxylation (GO:0018126)4.09102670
23regulation of natural killer cell differentiation (GO:0032823)4.08557804
24definitive hemopoiesis (GO:0060216)4.02349876
25regulation of T-helper 1 cell differentiation (GO:0045625)3.99318937
26melanin metabolic process (GO:0006582)3.96894566
27energy homeostasis (GO:0097009)3.84482734
28negative regulation of keratinocyte proliferation (GO:0010839)3.83294942
29dendritic cell chemotaxis (GO:0002407)3.77067536
30positive regulation of respiratory burst (GO:0060267)3.72718594
31detection of other organism (GO:0098543)3.71255815
32negative regulation of catenin import into nucleus (GO:0035414)3.68887131
33detection of molecule of bacterial origin (GO:0032490)3.63588964
34barbed-end actin filament capping (GO:0051016)3.62212563
35positive regulation of gamma-delta T cell activation (GO:0046645)3.60722785
36regulation of chemokine biosynthetic process (GO:0045073)3.55236583
37positive regulation of astrocyte differentiation (GO:0048711)3.52642310
38substrate-dependent cell migration (GO:0006929)3.52398178
39detection of bacterium (GO:0016045)3.50450652
40regulation of metalloenzyme activity (GO:0048552)3.49290057
41secondary metabolite biosynthetic process (GO:0044550)3.47546762
42daunorubicin metabolic process (GO:0044597)3.45116522
43polyketide metabolic process (GO:0030638)3.45116522
44doxorubicin metabolic process (GO:0044598)3.45116522
45postsynaptic membrane organization (GO:0001941)3.42631286
46muscle cell migration (GO:0014812)3.40915157
47replication fork processing (GO:0031297)3.38778266
48type B pancreatic cell proliferation (GO:0044342)3.35313242
49negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.33098069
50cell migration involved in heart development (GO:0060973)3.31608841
51endothelial cell chemotaxis (GO:0035767)3.30502185
52negative regulation of stem cell proliferation (GO:2000647)3.29265807
53germinal center formation (GO:0002467)3.27146814
54detection of external biotic stimulus (GO:0098581)3.24675073
55response to peptidoglycan (GO:0032494)3.23711886
56wound healing, spreading of epidermal cells (GO:0035313)3.21078225
57dendritic cell migration (GO:0036336)3.19398471
58regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.18709138
59neutrophil activation involved in immune response (GO:0002283)3.17967292
60dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.17440962
61glial cell migration (GO:0008347)3.17217361
62endothelial cell morphogenesis (GO:0001886)3.16540578
63negative regulation of myeloid cell apoptotic process (GO:0033033)3.16203436
64regulation of vitamin D biosynthetic process (GO:0060556)3.15548037
65actin filament depolymerization (GO:0030042)3.14264028
66chondrocyte proliferation (GO:0035988)3.12585323
67nuclear envelope reassembly (GO:0031468)3.12078043
68mitotic nuclear envelope reassembly (GO:0007084)3.12078043
69negative regulation of viral genome replication (GO:0045071)3.11808849
70regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.11171373
71negative regulation of mast cell activation (GO:0033004)3.09955125
72membrane raft organization (GO:0031579)3.08566262
73positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08078826
74negative regulation of erythrocyte differentiation (GO:0045647)3.08019887
75regulation of tight junction assembly (GO:2000810)3.06293471
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.06086719
77negative regulation of anoikis (GO:2000811)3.05873734
78collagen metabolic process (GO:0032963)3.03716684
79galactose catabolic process (GO:0019388)3.03679383
80valine metabolic process (GO:0006573)3.02632445
81collagen catabolic process (GO:0030574)3.02288899
82positive regulation of interleukin-1 beta secretion (GO:0050718)3.01135556
83positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.98660886
84negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.98163611
85negative regulation of nitric oxide biosynthetic process (GO:0045019)2.98072613
86negative regulation of cartilage development (GO:0061037)2.97527646
87cellular response to zinc ion (GO:0071294)2.96537005
88semaphorin-plexin signaling pathway (GO:0071526)2.96484491
89extracellular matrix disassembly (GO:0022617)2.96103419
90phospholipid scrambling (GO:0017121)2.94974373
91antigen processing and presentation of endogenous antigen (GO:0019883)2.94957116
92regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94588106
93decidualization (GO:0046697)2.94417034
94regulation of myeloid cell apoptotic process (GO:0033032)2.93407412
95positive regulation of T-helper cell differentiation (GO:0045624)2.92603703
96protein heterotetramerization (GO:0051290)2.91029225
97maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89527216
98regulation of mammary gland epithelial cell proliferation (GO:0033599)2.89079513
99meiotic chromosome segregation (GO:0045132)2.87956562
100antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.87184722
101antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87184722
102cellular response to vitamin D (GO:0071305)2.87157238
103regulation of activation of Janus kinase activity (GO:0010533)2.86851231
104endosome to melanosome transport (GO:0035646)2.86306079
105endosome to pigment granule transport (GO:0043485)2.86306079
106detection of biotic stimulus (GO:0009595)2.86202387
107pinocytosis (GO:0006907)2.85645778
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.84682078
109regulation of anoikis (GO:2000209)2.84648497
110B cell mediated immunity (GO:0019724)2.83777419
111regulation of interleukin-1 beta secretion (GO:0050706)2.83197012
112respiratory burst (GO:0045730)2.82653532
113retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.81849735
1144-hydroxyproline metabolic process (GO:0019471)2.81315533
115positive regulation of leukocyte apoptotic process (GO:2000108)2.79802659
116negative regulation of homotypic cell-cell adhesion (GO:0034111)2.79347661
117myeloid dendritic cell activation (GO:0001773)2.78698070
118regulation of apoptotic process involved in morphogenesis (GO:1902337)2.77245856
119reactive oxygen species biosynthetic process (GO:1903409)2.75356256
120antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.75296218
121positive regulation of monocyte chemotaxis (GO:0090026)2.75051072
122neutrophil activation (GO:0042119)2.74503012
123multicellular organismal macromolecule metabolic process (GO:0044259)2.74295693
124positive regulation of interleukin-1 secretion (GO:0050716)2.74169036
125positive regulation of osteoblast proliferation (GO:0033690)2.74127816
126regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73443669
127folic acid-containing compound biosynthetic process (GO:0009396)2.73024714
128cellular copper ion homeostasis (GO:0006878)2.72943674
129lipoxygenase pathway (GO:0019372)2.72647007
130myoblast migration (GO:0051451)2.71879359
131activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.71069404
132regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.70524019
133mesenchymal cell differentiation involved in renal system development (GO:2001012)2.70295332
134mesenchymal cell differentiation involved in kidney development (GO:0072161)2.70295332
135adhesion of symbiont to host (GO:0044406)2.69977454
136extracellular fibril organization (GO:0043206)2.69537703
137multicellular organismal catabolic process (GO:0044243)2.69444143
138positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.68617559
139negative regulation of cell size (GO:0045792)2.68070077
140negative regulation of adherens junction organization (GO:1903392)2.68016285
141negative regulation of focal adhesion assembly (GO:0051895)2.68016285
142negative regulation of cell junction assembly (GO:1901889)2.68016285
143membrane protein ectodomain proteolysis (GO:0006509)2.68011663
144lung vasculature development (GO:0060426)2.67222759
145cellular protein complex localization (GO:0034629)2.67074087
146positive regulation of T cell chemotaxis (GO:0010820)2.66007347
147regulation of T cell chemotaxis (GO:0010819)2.66007347
148positive regulation of odontogenesis (GO:0042482)2.65818186
149wound healing, spreading of cells (GO:0044319)2.64891757
150positive regulation of protein homodimerization activity (GO:0090073)2.64226888
151regulation of water loss via skin (GO:0033561)2.63557649
152positive regulation of B cell differentiation (GO:0045579)2.62745075
153galactose metabolic process (GO:0006012)2.61872214
154cellular response to vitamin (GO:0071295)2.61073372
155response to interferon-alpha (GO:0035455)2.60958826
156extracellular regulation of signal transduction (GO:1900115)2.59995997
157extracellular negative regulation of signal transduction (GO:1900116)2.59995997
158COPII vesicle coating (GO:0048208)2.59902079
159positive regulation of pseudopodium assembly (GO:0031274)2.59556263
160regulation of natural killer cell activation (GO:0032814)2.59377159
161UV protection (GO:0009650)2.58996177
162adhesion of symbiont to host cell (GO:0044650)2.58080594
163virion attachment to host cell (GO:0019062)2.58080594
164positive regulation of nuclease activity (GO:0032075)2.57344121
165positive regulation of natural killer cell activation (GO:0032816)2.57191892
166branching involved in mammary gland duct morphogenesis (GO:0060444)2.56440012
167endoplasmic reticulum unfolded protein response (GO:0030968)2.56122616
168lipopolysaccharide biosynthetic process (GO:0009103)2.55985877
169multicellular organismal metabolic process (GO:0044236)2.55096192
170cell-substrate adherens junction assembly (GO:0007045)2.54937081
171focal adhesion assembly (GO:0048041)2.54937081
172face development (GO:0060324)2.54631105
173positive regulation of T-helper 1 type immune response (GO:0002827)2.54389442
174ribosomal small subunit assembly (GO:0000028)2.53738190
175positive regulation of heat generation (GO:0031652)2.53318780
176leukocyte aggregation (GO:0070486)2.52386259
177regulation of hypersensitivity (GO:0002883)2.52251008
178granulocyte activation (GO:0036230)2.51851500
179regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.51815220
180negative regulation of T cell mediated immunity (GO:0002710)2.50778731
181regulation of interleukin-8 secretion (GO:2000482)2.50754608
182regulation of mast cell activation (GO:0033003)2.50144794
183presynaptic membrane assembly (GO:0097105)2.49322488
184angiogenesis involved in wound healing (GO:0060055)2.49293546
185adenine nucleotide transport (GO:0051503)2.46109618
186positive regulation of response to biotic stimulus (GO:0002833)2.44765493
187skeletal muscle tissue regeneration (GO:0043403)2.44757224
188positive regulation of cellular amide metabolic process (GO:0034250)2.44344282
189cellular response to type I interferon (GO:0071357)2.43373234
190type I interferon signaling pathway (GO:0060337)2.43373234
191negative regulation of macrophage differentiation (GO:0045650)2.43032459
192regulation of T-helper 1 type immune response (GO:0002825)2.41874393
193positive regulation of mast cell activation (GO:0033005)2.41427067
194myeloid dendritic cell differentiation (GO:0043011)2.40758241
195regulation of T-helper cell differentiation (GO:0045622)2.40373317
196DNA strand renaturation (GO:0000733)2.40008072
197positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.40002556
198positive regulation of activated T cell proliferation (GO:0042104)2.38775724
199purine ribonucleotide transport (GO:0015868)2.38587385
200positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.38018150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.00147293
2GATA1_22025678_ChIP-Seq_K562_Human4.21324400
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.85606821
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.81178520
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.47096926
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.35734856
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.35668886
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.20662910
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.15477737
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.04625829
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.86337460
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.84049149
13ZNF263_19887448_ChIP-Seq_K562_Human2.80833463
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.71785674
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.68661881
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.63682867
17E2F7_22180533_ChIP-Seq_HELA_Human2.40488680
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31627630
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31011776
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28917331
21GBX2_23144817_ChIP-Seq_PC3_Human2.27465688
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.21935598
23PCGF2_27294783_Chip-Seq_NPCs_Mouse2.21328533
24* LXR_22292898_ChIP-Seq_THP-1_Human2.20193005
25RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.16453334
26* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15107744
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13642053
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.11051513
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.11051513
30HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09607119
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09049712
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.08462515
33SCL_19346495_ChIP-Seq_HPC-7_Human2.04811979
34* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.04354666
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.03763225
36RACK7_27058665_Chip-Seq_MCF-7_Human2.01333752
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.00960114
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96745936
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.96093002
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.93312534
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92016481
42ATF3_27146783_Chip-Seq_COLON_Human1.88562887
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.87482747
44EWS_26573619_Chip-Seq_HEK293_Human1.85638539
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.84222329
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.83037711
47TP53_22127205_ChIP-Seq_IMR90_Human1.82021090
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81298564
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80961369
50* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.77843269
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77009941
52* UBF1/2_26484160_Chip-Seq_HMECs_Human1.76131276
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73963385
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73494473
55P53_22387025_ChIP-Seq_ESCs_Mouse1.73415753
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.72667901
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70668012
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70485161
59IRF1_19129219_ChIP-ChIP_H3396_Human1.70475654
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.70201507
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68924950
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66299984
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.63528969
64RUNX_20019798_ChIP-Seq_JUKART_Human1.63461642
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63153778
66CLOCK_20551151_ChIP-Seq_293T_Human1.60927692
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.60053601
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60009799
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.59901182
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59679601
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58675282
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58374640
73P300_19829295_ChIP-Seq_ESCs_Human1.56882892
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.56336972
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.55988824
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53964688
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53378263
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52585896
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.51136641
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.50485332
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50306727
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49606514
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47731943
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47681719
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45738969
86PU1_27457419_Chip-Seq_LIVER_Mouse1.44637112
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43139134
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42920366
89NMYC_18555785_Chip-Seq_ESCs_Mouse1.40142468
90VDR_21846776_ChIP-Seq_THP-1_Human1.39884848
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39712200
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39139827
93P300_18555785_Chip-Seq_ESCs_Mouse1.38883736
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38052035
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37209228
96RUNX1_27457419_Chip-Seq_LIVER_Mouse1.36718302
97ZFX_18555785_Chip-Seq_ESCs_Mouse1.35217824
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34628414
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34424881
100VDR_22108803_ChIP-Seq_LS180_Human1.33664402
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33500269
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33391117
103MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32777771
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32452598
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.31566455
106* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31355707
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31285063
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.31108150
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.31019940
110AR_21909140_ChIP-Seq_LNCAP_Human1.29034945
111KLF4_18555785_Chip-Seq_ESCs_Mouse1.28780753
112KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27211908
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26820245
114SOX2_18555785_Chip-Seq_ESCs_Mouse1.26789715
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26635764
116TP53_18474530_ChIP-ChIP_U2OS_Human1.26397912
117VDR_24787735_ChIP-Seq_THP-1_Human1.26334927
118OCT4_18555785_Chip-Seq_ESCs_Mouse1.25843961
119ESR2_21235772_ChIP-Seq_MCF-7_Human1.24822584
120FOXM1_23109430_ChIP-Seq_U2OS_Human1.23822921
121TAL1_26923725_Chip-Seq_HPCs_Mouse1.23661971
122SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22131816
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21486131
124MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21044297
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19044927
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18638895
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18156459
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18156459
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17962379
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17372340
131MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16443684
132NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15836374
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14877661
134CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14189833
135SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12878401
136ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12509341
137SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10345901
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08736603
139RXR_22108803_ChIP-Seq_LS180_Human1.08414507
140RNF2_27304074_Chip-Seq_NSC_Mouse1.08064919
141CBX2_27304074_Chip-Seq_ESCs_Mouse1.07659725
142TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04581633
143FUS_26573619_Chip-Seq_HEK293_Human1.03983362
144SPI1_23547873_ChIP-Seq_NB4_Human1.03347000
145* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03255901
146TP53_23651856_ChIP-Seq_MEFs_Mouse1.02296241
147CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02233212
148CRX_20693478_ChIP-Seq_RETINA_Mouse1.02077692
149IGF1R_20145208_ChIP-Seq_DFB_Human1.01455363
150NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00952832
151CTCF_18555785_Chip-Seq_ESCs_Mouse1.00421201
152FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99864981
153NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99178252
154TP63_22573176_ChIP-Seq_HFKS_Human0.99150786
155MYC_18555785_ChIP-Seq_MESCs_Mouse0.98464425
156EED_16625203_ChIP-ChIP_MESCs_Mouse0.98378102
157ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96783876
158STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96783361
159SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96339904
160ERG_21242973_ChIP-ChIP_JURKAT_Human0.96268034
161JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95814251
162CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95092950
163SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94741372
164SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94712260
165CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94626956
166BRD4_25478319_ChIP-Seq_HGPS_Human0.94616375
167ELK1_19687146_ChIP-ChIP_HELA_Human0.94464306
168SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94285005
169SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93488070
170ESR1_21235772_ChIP-Seq_MCF-7_Human0.93169606
171NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92863023
172* P68_20966046_ChIP-Seq_HELA_Human0.92669182
173TET1_21490601_ChIP-Seq_MESCs_Mouse0.92567785
174NCOR1_26117541_ChIP-Seq_K562_Human0.92235442
175SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91742625
176RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91503821
177CJUN_26792858_Chip-Seq_BT549_Human0.91283615
178DCP1A_22483619_ChIP-Seq_HELA_Human0.91135939
179EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90923596
180SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90829621
181SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90487884
182MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90346040
183CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89679466
184EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89661730
185SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89570460
186TCF4_22108803_ChIP-Seq_LS180_Human0.89198960
187CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89110590
188SOX2_20726797_ChIP-Seq_SW620_Human0.88993540
189ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88270813
190SA1_27219007_Chip-Seq_ERYTHROID_Human0.88083969
191STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87949018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.63203622
2MP0004272_abnormal_basement_membrane3.99736436
3MP0005257_abnormal_intraocular_pressure3.95658406
4MP0002877_abnormal_melanocyte_morpholog3.82620531
5MP0001835_abnormal_antigen_presentation3.53761812
6MP0002254_reproductive_system_inflammat3.47763634
7MP0000579_abnormal_nail_morphology3.38172346
8MP0001986_abnormal_taste_sensitivity3.00169949
9MP0003566_abnormal_cell_adhesion2.94085149
10MP0003724_increased_susceptibility_to2.86914784
11MP0002148_abnormal_hypersensitivity_rea2.84958404
12MP0009785_altered_susceptibility_to2.78290463
13MP0002132_abnormal_respiratory_system2.76286811
14MP0002163_abnormal_gland_morphology2.65171761
15MP0005409_darkened_coat_color2.61844994
16MP0002876_abnormal_thyroid_physiology2.48214654
17MP0000569_abnormal_digit_pigmentation2.40391536
18MP0009697_abnormal_copulation2.33913278
19MP0004381_abnormal_hair_follicle2.32002332
20MP0005408_hypopigmentation2.16876600
21MP0002419_abnormal_innate_immunity2.15617024
22MP0005646_abnormal_pituitary_gland2.08757093
23MP0004782_abnormal_surfactant_physiolog2.07965779
24MP0001853_heart_inflammation2.07450429
25MP0009764_decreased_sensitivity_to2.07288352
26MP0005360_urolithiasis2.04729473
27MP0001849_ear_inflammation2.02502162
28MP0005379_endocrine/exocrine_gland_phen2.02299194
29MP0000762_abnormal_tongue_morphology2.00985498
30MP0002396_abnormal_hematopoietic_system2.00332516
31MP0005000_abnormal_immune_tolerance2.00174318
32MP0005025_abnormal_response_to1.97132891
33MP0003136_yellow_coat_color1.96497307
34MP0005023_abnormal_wound_healing1.93737720
35MP0005058_abnormal_lysosome_morphology1.89380705
36MP0001348_abnormal_lacrimal_gland1.88930768
37MP0000383_abnormal_hair_follicle1.87151502
38MP0005645_abnormal_hypothalamus_physiol1.86180956
39MP0006054_spinal_hemorrhage1.86128102
40MP0000013_abnormal_adipose_tissue1.81595096
41MP0005084_abnormal_gallbladder_morpholo1.78094931
42MP0004858_abnormal_nervous_system1.77360279
43MP0010030_abnormal_orbit_morphology1.74268204
44MP0003950_abnormal_plasma_membrane1.74192891
45MP0005671_abnormal_response_to1.71300868
46MP0009053_abnormal_anal_canal1.67948161
47MP0001188_hyperpigmentation1.65550821
48MP0003091_abnormal_cell_migration1.65489682
49MP0003453_abnormal_keratinocyte_physiol1.65474411
50MP0006292_abnormal_olfactory_placode1.65358050
51MP0001501_abnormal_sleep_pattern1.64530330
52MP0001819_abnormal_immune_cell1.63043704
53MP0002452_abnormal_antigen_presenting1.62924536
54MP0001958_emphysema1.62782789
55MP0000566_synostosis1.62612809
56MP0002420_abnormal_adaptive_immunity1.57545071
57MP0003436_decreased_susceptibility_to1.55720040
58MP0003279_aneurysm1.54412053
59MP0002723_abnormal_immune_serum1.54198608
60MP0003763_abnormal_thymus_physiology1.52808646
61MP0002060_abnormal_skin_morphology1.51338548
62MP0005075_abnormal_melanosome_morpholog1.50630672
63MP0002938_white_spotting1.49470119
64MP0000685_abnormal_immune_system1.49455573
65MP0000467_abnormal_esophagus_morphology1.49264938
66MP0001216_abnormal_epidermal_layer1.48896663
67MP0005167_abnormal_blood-brain_barrier1.48346946
68MP0010386_abnormal_urinary_bladder1.47651350
69MP0000371_diluted_coat_color1.44892828
70MP0005397_hematopoietic_system_phenotyp1.44357441
71MP0001545_abnormal_hematopoietic_system1.44357441
72MP0005387_immune_system_phenotype1.44291193
73MP0001790_abnormal_immune_system1.44291193
74MP0005197_abnormal_uvea_morphology1.42974387
75MP0002006_tumorigenesis1.42849818
76MP0002998_abnormal_bone_remodeling1.40600754
77MP0005451_abnormal_body_composition1.40529202
78MP0005503_abnormal_tendon_morphology1.40199448
79MP0002089_abnormal_postnatal_growth/wei1.39875919
80MP0000751_myopathy1.37508396
81MP0009840_abnormal_foam_cell1.36976776
82MP0008260_abnormal_autophagy1.35731329
83MP0001800_abnormal_humoral_immune1.35291764
84MP0000015_abnormal_ear_pigmentation1.35081005
85MP0005623_abnormal_meninges_morphology1.34321168
86MP0002075_abnormal_coat/hair_pigmentati1.32511609
87MP0000003_abnormal_adipose_tissue1.25421780
88MP0003191_abnormal_cellular_cholesterol1.22091669
89MP0001346_abnormal_lacrimal_gland1.21706605
90MP0008057_abnormal_DNA_replication1.20402130
91MP0000750_abnormal_muscle_regeneration1.19903086
92MP0004233_abnormal_muscle_weight1.19616466
93MP0003172_abnormal_lysosome_physiology1.18453856
94MP0003186_abnormal_redox_activity1.17031061
95MP0000534_abnormal_ureter_morphology1.16480163
96MP0005275_abnormal_skin_tensile1.16301073
97MP0008058_abnormal_DNA_repair1.15830556
98MP0010234_abnormal_vibrissa_follicle1.14240755
99MP0001186_pigmentation_phenotype1.12798998
100MP0005174_abnormal_tail_pigmentation1.12125052
101MP0004808_abnormal_hematopoietic_stem1.11857792
102MP0002735_abnormal_chemical_nociception1.10674991
103MP0002796_impaired_skin_barrier1.10511917
104MP0002896_abnormal_bone_mineralization1.10242998
105MP0008007_abnormal_cellular_replicative1.09278246
106MP0000681_abnormal_thyroid_gland1.09212601
107MP0008438_abnormal_cutaneous_collagen1.08656352
108MP0003787_abnormal_imprinting1.08385580
109MP0008877_abnormal_DNA_methylation1.07634316
110MP0005670_abnormal_white_adipose1.06810327
111MP0002398_abnormal_bone_marrow1.05920845
112MP0005501_abnormal_skin_physiology1.03987698
113MP0009333_abnormal_splenocyte_physiolog1.03264911
114MP0000733_abnormal_muscle_development1.01709002
115MP0005464_abnormal_platelet_physiology0.99785277
116MP0001845_abnormal_inflammatory_respons0.97751376
117MP0001542_abnormal_bone_strength0.97682665
118MP0002295_abnormal_pulmonary_circulatio0.97383458
119MP0000372_irregular_coat_pigmentation0.96404271
120MP0005171_absent_coat_pigmentation0.94676548
121MP0009379_abnormal_foot_pigmentation0.94167986
122MP0005390_skeleton_phenotype0.94047789
123MP0002405_respiratory_system_inflammati0.93596278
124MP0000716_abnormal_immune_system0.92512752
125MP0003828_pulmonary_edema0.91601048
126MP0002277_abnormal_respiratory_mucosa0.91183205
127MP0003075_altered_response_to0.90091655
128MP0001119_abnormal_female_reproductive0.89138132
129MP0000858_altered_metastatic_potential0.87914647
130MP0001299_abnormal_eye_distance/0.87912614
131MP0001533_abnormal_skeleton_physiology0.87565900
132MP0010155_abnormal_intestine_physiology0.87136400
133MP0002177_abnormal_outer_ear0.85917869
134MP0001191_abnormal_skin_condition0.85617364
135MP0003448_altered_tumor_morphology0.85082543
136MP0005165_increased_susceptibility_to0.84911888
137MP0010771_integument_phenotype0.84319752
138MP0003941_abnormal_skin_development0.83633994
139MP0001243_abnormal_dermal_layer0.83570599
140MP0010678_abnormal_skin_adnexa0.82269234
141MP0002095_abnormal_skin_pigmentation0.81740722
142MP0001881_abnormal_mammary_gland0.81733382
143MP0000749_muscle_degeneration0.81603905
144MP0003943_abnormal_hepatobiliary_system0.78526211
145MP0001661_extended_life_span0.77200401
146MP0010368_abnormal_lymphatic_system0.76882849
147MP0000343_altered_response_to0.76820881
148MP0002429_abnormal_blood_cell0.76315563
149MP0003183_abnormal_peptide_metabolism0.75629700
150MP0000767_abnormal_smooth_muscle0.75186615
151MP0005164_abnormal_response_to0.74634215
152MP0009384_cardiac_valve_regurgitation0.73451549
153MP0005508_abnormal_skeleton_morphology0.73428438
154MP0000377_abnormal_hair_follicle0.72957800
155MP0000367_abnormal_coat/_hair0.72069508
156MP0004742_abnormal_vestibular_system0.71959015
157MP0002009_preneoplasia0.71191524
158MP0009931_abnormal_skin_appearance0.70776677
159MP0003315_abnormal_perineum_morphology0.70641648
160MP0000627_abnormal_mammary_gland0.69928775
161MP0005193_abnormal_anterior_eye0.69695776
162MP0004510_myositis0.69562084
163MP0002166_altered_tumor_susceptibility0.69180909
164MP0005330_cardiomyopathy0.67773648
165MP0001915_intracranial_hemorrhage0.67635512
166MP0003786_premature_aging0.65827021
167MP0003045_fibrosis0.65295188
168MP0002098_abnormal_vibrissa_morphology0.65283372
169MP0000163_abnormal_cartilage_morphology0.64935501
170MP0000678_abnormal_parathyroid_gland0.64904136
171MP0008932_abnormal_embryonic_tissue0.64555335
172MP0003634_abnormal_glial_cell0.64187971
173MP0005621_abnormal_cell_physiology0.62904116
174MP0004185_abnormal_adipocyte_glucose0.61971009
175MP0003385_abnormal_body_wall0.61608872

Predicted human phenotypes

RankGene SetZ-score
1Spinal cord lesions (HP:0100561)6.12981101
2Syringomyelia (HP:0003396)6.12981101
3Premature rupture of membranes (HP:0001788)5.45129603
4Short middle phalanx of the 5th finger (HP:0004220)4.97035334
5Milia (HP:0001056)4.41803050
6Recurrent abscess formation (HP:0002722)3.88223734
7Protrusio acetabuli (HP:0003179)3.82741768
8Absent frontal sinuses (HP:0002688)3.81295516
9Agnosia (HP:0010524)3.73434765
10Prostate neoplasm (HP:0100787)3.67687010
11Fragile skin (HP:0001030)3.65166937
12Recurrent bacterial skin infections (HP:0005406)3.64934520
13Vertebral compression fractures (HP:0002953)3.61988251
14Metaphyseal dysplasia (HP:0100255)3.59867617
15Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.52296523
16Distal upper limb amyotrophy (HP:0007149)3.44011727
17Upper limb amyotrophy (HP:0009129)3.44011727
18Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.42710645
19Hand muscle atrophy (HP:0009130)3.42061213
20Abnormality of the phalanges of the 5th finger (HP:0004213)3.29755752
21Distal lower limb muscle weakness (HP:0009053)3.20897378
22Increased IgM level (HP:0003496)3.14192816
23Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.04724150
24Ulnar bowing (HP:0003031)3.01934632
25Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.00447867
26Thyroid-stimulating hormone excess (HP:0002925)2.97202424
27Myositis (HP:0100614)2.93860285
28Mediastinal lymphadenopathy (HP:0100721)2.93294505
29Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.92775649
30Heterochromia iridis (HP:0001100)2.92542733
31Eczematoid dermatitis (HP:0000976)2.90453819
32Abnormality of the distal phalanges of the toes (HP:0010182)2.87193738
33Myocardial infarction (HP:0001658)2.86286540
34Alopecia of scalp (HP:0002293)2.84761431
35Elbow flexion contracture (HP:0002987)2.84234454
36Thick nail (HP:0001805)2.81262504
37Ankle contracture (HP:0006466)2.81002985
38Nail dystrophy (HP:0008404)2.80245658
39Retrobulbar optic neuritis (HP:0100654)2.79489683
40Optic neuritis (HP:0100653)2.79489683
41Aplasia involving bones of the upper limbs (HP:0009823)2.77874649
42Aplasia of the phalanges of the hand (HP:0009802)2.77874649
43Aplasia involving bones of the extremities (HP:0009825)2.77874649
44Reduced subcutaneous adipose tissue (HP:0003758)2.76713167
45Spinal rigidity (HP:0003306)2.76143942
46Short nail (HP:0001799)2.75529752
47Achilles tendon contracture (HP:0001771)2.69522456
48Chronic obstructive pulmonary disease (HP:0006510)2.68697074
49Obstructive lung disease (HP:0006536)2.68697074
50Cerebral aneurysm (HP:0004944)2.64856834
51Ridged nail (HP:0001807)2.64319876
52Fibular aplasia (HP:0002990)2.62271193
53Type I transferrin isoform profile (HP:0003642)2.60838679
54Abnormality of the frontal sinuses (HP:0002687)2.60517612
55Follicular hyperkeratosis (HP:0007502)2.60208055
56Abnormality of the umbilical cord (HP:0010881)2.58787014
57Asymmetry of the thorax (HP:0001555)2.56882362
58Plantar hyperkeratosis (HP:0007556)2.55011510
59Type 2 muscle fiber atrophy (HP:0003554)2.54757250
60Short 5th finger (HP:0009237)2.54451955
61Dry hair (HP:0011359)2.53909235
62Abnormality of liposaccharide metabolism (HP:0010968)2.52153990
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.52153990
64Abnormality of glycolipid metabolism (HP:0010969)2.52153990
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.51696243
66Osteolytic defects of the hand bones (HP:0009699)2.51696243
67Abnormality of the fetal cardiovascular system (HP:0010948)2.51412590
68Abnormal umbilical cord blood vessels (HP:0011403)2.51412590
69Single umbilical artery (HP:0001195)2.51412590
70Distal lower limb amyotrophy (HP:0008944)2.51288939
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.49748019
72Abnormal hair whorl (HP:0010721)2.49666093
73Long foot (HP:0001833)2.49162634
74Hypopigmentation of the fundus (HP:0007894)2.46703940
75J-shaped sella turcica (HP:0002680)2.45806684
76Orchitis (HP:0100796)2.44064089
77Increased connective tissue (HP:0009025)2.42080321
78Xerostomia (HP:0000217)2.41721674
79Wormian bones (HP:0002645)2.41450567
80Upper limb muscle weakness (HP:0003484)2.41034533
81Selective tooth agenesis (HP:0001592)2.39776934
82Congenital, generalized hypertrichosis (HP:0004540)2.39528340
83Chronic otitis media (HP:0000389)2.38294542
84Biconcave vertebral bodies (HP:0004586)2.38044100
85Abnormality of the Achilles tendon (HP:0005109)2.37973691
86Thrombocytosis (HP:0001894)2.36646473
87Abnormality of the prostate (HP:0008775)2.36162511
88White forelock (HP:0002211)2.35792541
89Broad face (HP:0000283)2.33855147
90Bladder diverticulum (HP:0000015)2.30028247
91Abnormality of oral frenula (HP:0000190)2.29633151
92Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.29323882
93Ankyloglossia (HP:0010296)2.29230557
94Glomerulopathy (HP:0100820)2.29113824
95Stomatitis (HP:0010280)2.28289055
96Basal ganglia calcification (HP:0002135)2.27733597
97Patchy hypopigmentation of hair (HP:0011365)2.26597646
98Abnormality of macrophages (HP:0004311)2.23736416
99Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23190116
100Onycholysis (HP:0001806)2.22000813
101Abnormality of nail color (HP:0100643)2.21296664
102Trismus (HP:0000211)2.21070533
103Abnormality of DNA repair (HP:0003254)2.19725606
104Pancreatic fibrosis (HP:0100732)2.17209634
105Insomnia (HP:0100785)2.16460963
106Glucose intolerance (HP:0000833)2.15826830
107Absent epiphyses (HP:0010577)2.15028213
108Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.15028213
109Blue sclerae (HP:0000592)2.14454429
110Difficulty climbing stairs (HP:0003551)2.13966033
111Recurrent gram-negative bacterial infections (HP:0005420)2.13562873
112Reduced antithrombin III activity (HP:0001976)2.09801176
113Mildly elevated creatine phosphokinase (HP:0008180)2.09317036
114Hyperacusis (HP:0010780)2.09130656
115Nonprogressive disorder (HP:0003680)2.09102112
116Fatigable weakness (HP:0003473)2.07686935
117Abnormality of the neuromuscular junction (HP:0003398)2.07686935
118Cervical subluxation (HP:0003308)2.07650387
119Keratoconjunctivitis sicca (HP:0001097)2.07478613
120Elevated erythrocyte sedimentation rate (HP:0003565)2.07464861
121Shallow orbits (HP:0000586)2.06999593
122Alveolar cell carcinoma (HP:0006519)2.06815775
123Entropion (HP:0000621)2.06287932
124Generalized amyotrophy (HP:0003700)2.05045985
125Premature graying of hair (HP:0002216)2.04402317
126Chromsome breakage (HP:0040012)2.03612978
127Flat acetabular roof (HP:0003180)2.02410315
128Abnormal ossification of hand bones (HP:0005921)2.02242481
129Ocular albinism (HP:0001107)2.02203403
130Keratoconjunctivitis (HP:0001096)2.02131068
131Gingivitis (HP:0000230)2.01358925
132Median cleft lip (HP:0000161)1.98722665
133Abnormality of carpal bone ossification (HP:0006257)1.98437998
134Abnormality of dentin (HP:0010299)1.97067529
135Coxa vara (HP:0002812)1.95028567
136Abnormalities of placenta or umbilical cord (HP:0001194)1.93577256
137Hypoalphalipoproteinemia (HP:0003233)1.92400808
138Amaurosis fugax (HP:0100576)1.91844253
139Hypergammaglobulinemia (HP:0010702)1.91770133
140Small epiphyses (HP:0010585)1.91726077
141Craniofacial hyperostosis (HP:0004493)1.91293053
142Arterial tortuosity (HP:0005116)1.90978720
143Flattened epiphyses (HP:0003071)1.89365728
144Recurrent pneumonia (HP:0006532)1.88081474
145Muscle fiber atrophy (HP:0100295)1.87839671
146Natal tooth (HP:0000695)1.87167128
147Rough bone trabeculation (HP:0100670)1.86284753
148Cardiovascular calcification (HP:0011915)1.85618682
149Vascular tortuosity (HP:0004948)1.85285629
150Aortic dissection (HP:0002647)1.85221590
151Keratitis (HP:0000491)1.85190694
152Delayed closure of the anterior fontanelle (HP:0001476)1.85073473
153Hypoplasia of the iris (HP:0007676)1.84996782
154Corneal dystrophy (HP:0001131)1.84584976
155Acute myeloid leukemia (HP:0004808)1.83938523
156Fragile nails (HP:0001808)1.83822761
157IgM deficiency (HP:0002850)1.83478279
158Peripheral hypomyelination (HP:0007182)1.83185117
159Abnormal blistering of the skin (HP:0008066)1.82937363
160Petechiae (HP:0000967)1.81596279
161Advanced eruption of teeth (HP:0006288)1.80654389
162Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80596020
163Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80596020
164Aplasia of the musculature (HP:0100854)1.80220550
165Squamous cell carcinoma (HP:0002860)1.79954921
166Blue irides (HP:0000635)1.79894297
167Thickened calvaria (HP:0002684)1.79203495
168Bowed forearm bones (HP:0003956)1.78098298
169Bowing of the arm (HP:0006488)1.78098298
170Long toe (HP:0010511)1.77844206
171Recurrent skin infections (HP:0001581)1.77698600
172Vascular calcification (HP:0004934)1.77634210
173Abnormality of dental color (HP:0011073)1.77263086
174Abnormality of the columella (HP:0009929)1.76958718
175Fatigue (HP:0012378)1.76176915
17611 pairs of ribs (HP:0000878)1.75361254
177Disproportionate tall stature (HP:0001519)1.74719210
178Cheilitis (HP:0100825)1.74355935
179Stridor (HP:0010307)1.74039543
180Colon cancer (HP:0003003)1.73775480
181Pulmonary infiltrates (HP:0002113)1.72941836
182Abnormality of primary teeth (HP:0006481)1.72554948
183Short clavicles (HP:0000894)1.69799413
184Pterygium (HP:0001059)1.69786046
185Ectropion (HP:0000656)1.68716656
186Vasculitis (HP:0002633)1.68218614
187Atrophic scars (HP:0001075)1.67635229
188Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65610122
189Weak cry (HP:0001612)1.62915107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.58179145
2SIK34.21380132
3MAP3K143.82184401
4LMTK23.66588986
5MAP3K33.29518789
6INSRR2.98450293
7JAK32.85386944
8PAK42.85116666
9TTN2.82021319
10TESK12.77000927
11LIMK12.72227592
12IRAK42.67009511
13ERBB32.65689785
14ERN12.44501190
15ARAF2.44131143
16TESK22.39642139
17NEK62.37306274
18MST1R2.36526150
19ERBB42.32224758
20PTK22.29690847
21EPHB22.19546484
22NME22.12279897
23MAP2K32.00567040
24TRPM71.98170622
25MET1.94998937
26TXK1.84566049
27MAP3K121.83789000
28PIM21.77617657
29PDGFRA1.77342184
30MOS1.75425264
31TRIB31.73134592
32ICK1.69795582
33MAPKAPK31.54261466
34NTRK11.48008385
35CASK1.46795106
36CDK191.46494593
37EIF2AK21.45650320
38BMPR21.45581127
39MUSK1.40093081
40ADRBK21.38914734
41MAP2K71.37547263
42MKNK11.36896958
43BTK1.33825028
44MAP3K111.31651390
45YES11.30495705
46EPHB11.29137516
47IKBKE1.28175902
48LATS21.28012438
49MKNK21.22181720
50SYK1.21660220
51TEC1.20538918
52TNIK1.19530026
53CCNB11.19506075
54KIT1.18915862
55PKN21.18366321
56IKBKB1.18156115
57ZAK1.17773833
58TAOK21.16739057
59RIPK11.12485543
60SGK21.11340860
61PLK21.11265585
62VRK21.08248519
63MAPK121.07649254
64STK161.07364822
65TGFBR21.07221374
66PRKD21.07064132
67DDR21.05431402
68MAPK71.05067250
69SMG11.02429444
70PTK61.02389459
71BMPR1B1.02305709
72STK240.97228509
73PINK10.96587097
74TNK20.94463916
75CDK120.92835187
76MAP4K10.88800002
77BRAF0.86469541
78CDC70.85797790
79GRK10.85651141
80MTOR0.84907880
81RPS6KA20.84358288
82PIM10.83333865
83GRK70.82699035
84STK100.82532031
85TIE10.81787275
86PAK20.79849861
87RPS6KB10.79730591
88LYN0.79167557
89CDK90.78623797
90MAP3K60.77383128
91AKT30.74663348
92CSF1R0.73509923
93CHUK0.72449295
94MAP3K20.72081121
95BLK0.71910790
96MAPK40.71015451
97PAK10.70613182
98RIPK40.70236118
99TYK20.68431148
100PBK0.68263029
101RPS6KL10.68223644
102RPS6KC10.68223644
103BUB10.67692713
104PHKG10.67204141
105PHKG20.67204141
106PRKD30.65379109
107SIK20.65254890
108AURKA0.64536009
109SGK30.64468913
110RPS6KB20.63653754
111DYRK1A0.63309303
112RPS6KA60.62608221
113MAP3K80.61747402
114GSK3A0.61290307
115CDC42BPA0.61015949
116BRSK10.61008716
117HCK0.60840443
118PTK2B0.60568184
119PDK20.60162618
120CLK10.59613057
121PRKCD0.58947422
122MARK30.58904385
123SIK10.57957674
124STK380.57560889
125FLT30.57489670
126NEK90.57368624
127ZAP700.57320869
128EIF2AK30.57246690
129ILK0.56458169
130NUAK10.56107747
131ADRBK10.53794938
132TBK10.52331336
133PRKCE0.51903147
134PIK3CG0.51867350
135MYLK0.50004341
136ROCK20.49070327
137MAP3K10.48168276
138FGR0.47243090
139CDK30.47056025
140BMX0.46256378
141PRKG20.46024288
142ABL20.45789124
143MAP3K50.45199013
144NEK10.44252435
145PRPF4B0.43342578
146CAMK2G0.43094890
147MAPK130.42416645
148DAPK30.42140898
149MAPKAPK20.42081685
150CDK80.41748192
151ROCK10.41540786
152LCK0.41483194
153PDGFRB0.41452053
154MAPKAPK50.41061141
155CDK70.40744189
156PLK40.39564383
157TSSK60.39428221
158RPS6KA40.39083721
159JAK10.38743496
160MAPK30.38696299
161VRK10.38022622
162EPHA20.35862036
163SGK2230.35326284
164SGK4940.35326284
165DAPK10.33638686
166PDPK10.32747805
167PRKCI0.30149331
168PRKD10.29200600
169WEE10.25955482
170HIPK20.25063302
171AKT20.23712026
172MAPK110.23585453
173CDK60.23362703
174CDK150.22994106
175CDK11A0.22643929
176RAF10.21530736
177CDK180.21482912

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.56204413
2Other glycan degradation_Homo sapiens_hsa005113.46228264
3Allograft rejection_Homo sapiens_hsa053303.31598575
4Graft-versus-host disease_Homo sapiens_hsa053322.92429423
5Type I diabetes mellitus_Homo sapiens_hsa049402.39308592
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.34651451
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.28554379
8Focal adhesion_Homo sapiens_hsa045102.27705204
9Sulfur relay system_Homo sapiens_hsa041222.24588291
10Small cell lung cancer_Homo sapiens_hsa052222.23733916
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10367225
12Bladder cancer_Homo sapiens_hsa052192.08627530
13Vitamin digestion and absorption_Homo sapiens_hsa049772.07504646
14Autoimmune thyroid disease_Homo sapiens_hsa053202.04335213
15Fructose and mannose metabolism_Homo sapiens_hsa000512.01657932
16Leishmaniasis_Homo sapiens_hsa051401.90000275
17Lysosome_Homo sapiens_hsa041421.86619473
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84243593
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.81931331
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.79998316
21Biosynthesis of amino acids_Homo sapiens_hsa012301.79131583
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.78316535
23Measles_Homo sapiens_hsa051621.77763462
24Rheumatoid arthritis_Homo sapiens_hsa053231.76382719
25Legionellosis_Homo sapiens_hsa051341.74771178
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.74734209
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.71414388
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.70055232
29Protein export_Homo sapiens_hsa030601.67542211
30Hematopoietic cell lineage_Homo sapiens_hsa046401.66988248
31Phagosome_Homo sapiens_hsa041451.63334555
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63299837
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.62685530
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.58606845
35Asthma_Homo sapiens_hsa053101.57301564
36Base excision repair_Homo sapiens_hsa034101.55400736
37N-Glycan biosynthesis_Homo sapiens_hsa005101.51477292
38African trypanosomiasis_Homo sapiens_hsa051431.50273037
39Thyroid cancer_Homo sapiens_hsa052161.49652440
40Mismatch repair_Homo sapiens_hsa034301.48575334
41Pentose phosphate pathway_Homo sapiens_hsa000301.47707273
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.47244151
43Malaria_Homo sapiens_hsa051441.46512194
44Proteoglycans in cancer_Homo sapiens_hsa052051.45757444
45Herpes simplex infection_Homo sapiens_hsa051681.44598425
46Sulfur metabolism_Homo sapiens_hsa009201.39796610
47Proteasome_Homo sapiens_hsa030501.38230685
48Protein digestion and absorption_Homo sapiens_hsa049741.36749923
49Prion diseases_Homo sapiens_hsa050201.34753876
50RNA polymerase_Homo sapiens_hsa030201.34644202
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32559065
52Homologous recombination_Homo sapiens_hsa034401.31097488
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30616245
54Influenza A_Homo sapiens_hsa051641.28828818
55Viral myocarditis_Homo sapiens_hsa054161.28636688
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26266543
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23693619
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22364160
59Ribosome_Homo sapiens_hsa030101.21532341
60Pertussis_Homo sapiens_hsa051331.19679480
61Jak-STAT signaling pathway_Homo sapiens_hsa046301.17938962
62TNF signaling pathway_Homo sapiens_hsa046681.17935846
63Dilated cardiomyopathy_Homo sapiens_hsa054141.14416726
64Histidine metabolism_Homo sapiens_hsa003401.13915433
65Primary immunodeficiency_Homo sapiens_hsa053401.12992242
66Adherens junction_Homo sapiens_hsa045201.12933115
67Sphingolipid metabolism_Homo sapiens_hsa006001.12802037
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12042662
69Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11571402
70Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11467081
71Salmonella infection_Homo sapiens_hsa051321.10917433
72Osteoclast differentiation_Homo sapiens_hsa043801.10787233
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06654690
74PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04096400
75DNA replication_Homo sapiens_hsa030301.01405289
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99697721
77Ovarian steroidogenesis_Homo sapiens_hsa049130.98450616
78Chronic myeloid leukemia_Homo sapiens_hsa052200.98364872
79Tuberculosis_Homo sapiens_hsa051520.93982550
80Fanconi anemia pathway_Homo sapiens_hsa034600.92952092
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92901394
82Nicotine addiction_Homo sapiens_hsa050330.91584043
83Hepatitis B_Homo sapiens_hsa051610.87475565
84MicroRNAs in cancer_Homo sapiens_hsa052060.86512078
85p53 signaling pathway_Homo sapiens_hsa041150.82859980
86Apoptosis_Homo sapiens_hsa042100.82335858
87Toxoplasmosis_Homo sapiens_hsa051450.81178125
88Hippo signaling pathway_Homo sapiens_hsa043900.80530640
89Arachidonic acid metabolism_Homo sapiens_hsa005900.80169614
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80084215
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79778849
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79331627
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77697448
94Staphylococcus aureus infection_Homo sapiens_hsa051500.77360895
95Pathways in cancer_Homo sapiens_hsa052000.77208564
96Arginine biosynthesis_Homo sapiens_hsa002200.77125206
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77102103
98Folate biosynthesis_Homo sapiens_hsa007900.76232960
99Endocytosis_Homo sapiens_hsa041440.74732707
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73276596
101Serotonergic synapse_Homo sapiens_hsa047260.71967196
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.71841248
103Carbon metabolism_Homo sapiens_hsa012000.70726079
104Pancreatic cancer_Homo sapiens_hsa052120.68816283
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67865496
106Glutathione metabolism_Homo sapiens_hsa004800.66617471
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66532755
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65362518
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65287401
110Purine metabolism_Homo sapiens_hsa002300.62606020
111One carbon pool by folate_Homo sapiens_hsa006700.62558365
112Nucleotide excision repair_Homo sapiens_hsa034200.62355088
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60821053
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60607252
115Pyrimidine metabolism_Homo sapiens_hsa002400.60123150
116beta-Alanine metabolism_Homo sapiens_hsa004100.58953577
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58943061
118Notch signaling pathway_Homo sapiens_hsa043300.57578921
119Melanogenesis_Homo sapiens_hsa049160.57146420
120Synaptic vesicle cycle_Homo sapiens_hsa047210.56579677
121Chemokine signaling pathway_Homo sapiens_hsa040620.56390463
122Acute myeloid leukemia_Homo sapiens_hsa052210.56030532
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55864557
124Phenylalanine metabolism_Homo sapiens_hsa003600.55828562
125Spliceosome_Homo sapiens_hsa030400.55593253
126VEGF signaling pathway_Homo sapiens_hsa043700.54933121
127Taste transduction_Homo sapiens_hsa047420.54695668
128Morphine addiction_Homo sapiens_hsa050320.53633467
129Shigellosis_Homo sapiens_hsa051310.52496954
130RNA degradation_Homo sapiens_hsa030180.48440640
131Collecting duct acid secretion_Homo sapiens_hsa049660.47800030
132Melanoma_Homo sapiens_hsa052180.47604260
133Antigen processing and presentation_Homo sapiens_hsa046120.45896048
134Ether lipid metabolism_Homo sapiens_hsa005650.44037440
135Non-small cell lung cancer_Homo sapiens_hsa052230.43112836
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43079124
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42659274
138Complement and coagulation cascades_Homo sapiens_hsa046100.42449187
139Glioma_Homo sapiens_hsa052140.42292632
140Vibrio cholerae infection_Homo sapiens_hsa051100.42248365
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42179412
142Prostate cancer_Homo sapiens_hsa052150.41506473
143GnRH signaling pathway_Homo sapiens_hsa049120.41467304
144Basal cell carcinoma_Homo sapiens_hsa052170.41324766
145Calcium signaling pathway_Homo sapiens_hsa040200.40734964
146Fatty acid elongation_Homo sapiens_hsa000620.39411915
147HTLV-I infection_Homo sapiens_hsa051660.37491633
148Endometrial cancer_Homo sapiens_hsa052130.37195998
149Viral carcinogenesis_Homo sapiens_hsa052030.36719749
150ErbB signaling pathway_Homo sapiens_hsa040120.36340096
151Axon guidance_Homo sapiens_hsa043600.36173121
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35763145
153Neurotrophin signaling pathway_Homo sapiens_hsa047220.35570484
154Hedgehog signaling pathway_Homo sapiens_hsa043400.34903577
155Amoebiasis_Homo sapiens_hsa051460.34544965
156Hepatitis C_Homo sapiens_hsa051600.33899157
157HIF-1 signaling pathway_Homo sapiens_hsa040660.33729341
158Non-homologous end-joining_Homo sapiens_hsa034500.33277725
159Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29417995
160Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28706265
161Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26746515
162ECM-receptor interaction_Homo sapiens_hsa045120.26253088
163Tyrosine metabolism_Homo sapiens_hsa003500.24789231
164Leukocyte transendothelial migration_Homo sapiens_hsa046700.23056492
165Galactose metabolism_Homo sapiens_hsa000520.21474856
166Long-term depression_Homo sapiens_hsa047300.21018501
167Epstein-Barr virus infection_Homo sapiens_hsa051690.20693100

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