UCN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)8.55496725
2endocrine pancreas development (GO:0031018)7.67860695
3regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022357.13691832
4regulation of type B pancreatic cell apoptotic process (GO:2000674)6.68203752
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.58653034
6peptide hormone processing (GO:0016486)6.54045957
7COPII vesicle coating (GO:0048208)6.37523582
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.22446734
9glandular epithelial cell differentiation (GO:0002067)5.82528836
10signal peptide processing (GO:0006465)5.75985786
11insulin secretion (GO:0030073)5.69663027
12type B pancreatic cell development (GO:0003323)5.43693472
13protein retention in ER lumen (GO:0006621)5.39102220
14activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.36632432
15exocrine pancreas development (GO:0031017)5.27424314
16sequestering of metal ion (GO:0051238)5.21416341
17positive regulation of nuclease activity (GO:0032075)5.10183669
18vesicle coating (GO:0006901)5.06237398
19glandular epithelial cell development (GO:0002068)4.96854699
20ER overload response (GO:0006983)4.95776080
21* regulation of insulin secretion (GO:0050796)4.75002721
22* positive regulation of insulin secretion (GO:0032024)4.72283261
23negative regulation of glycoprotein biosynthetic process (GO:0010561)4.70545022
24cellular ketone body metabolic process (GO:0046950)4.68055578
25detection of calcium ion (GO:0005513)4.65923275
26regulation of nuclease activity (GO:0032069)4.64829437
27endoplasmic reticulum unfolded protein response (GO:0030968)4.45588599
28cellular response to unfolded protein (GO:0034620)4.38846207
29* regulation of peptide hormone secretion (GO:0090276)4.34460002
30nitric oxide mediated signal transduction (GO:0007263)4.34331716
31eosinophil chemotaxis (GO:0048245)4.32224649
32cellular response to topologically incorrect protein (GO:0035967)4.29150486
33* regulation of peptide secretion (GO:0002791)4.26676055
34ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.21512679
35ER-nucleus signaling pathway (GO:0006984)4.18278639
36peptide hormone secretion (GO:0030072)4.14529061
37ketone body metabolic process (GO:1902224)4.11998379
38peptide secretion (GO:0002790)4.05243245
39positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.02684467
40intra-Golgi vesicle-mediated transport (GO:0006891)4.00000963
41columnar/cuboidal epithelial cell development (GO:0002066)3.92484858
42negative regulation of insulin secretion (GO:0046676)3.91106100
43negative regulation of hormone biosynthetic process (GO:0032353)3.87921693
44* positive regulation of peptide hormone secretion (GO:0090277)3.83769128
45eosinophil migration (GO:0072677)3.78882352
46negative regulation of catecholamine secretion (GO:0033604)3.77686596
47cellular response to vitamin D (GO:0071305)3.77386943
48negative regulation of cytosolic calcium ion concentration (GO:0051481)3.74392321
49* regulation of hormone secretion (GO:0046883)3.74182793
50water-soluble vitamin biosynthetic process (GO:0042364)3.71669050
51negative regulation of norepinephrine secretion (GO:0010700)3.71642649
52* positive regulation of peptide secretion (GO:0002793)3.71018185
53regulation of glucokinase activity (GO:0033131)3.70678478
54regulation of hexokinase activity (GO:1903299)3.70678478
55regulation of Golgi to plasma membrane protein transport (GO:0042996)3.68471691
56cellular zinc ion homeostasis (GO:0006882)3.65010290
57inositol phosphate catabolic process (GO:0071545)3.62594922
58ER to Golgi vesicle-mediated transport (GO:0006888)3.62275558
59induction of positive chemotaxis (GO:0050930)3.58392690
60protein N-linked glycosylation via asparagine (GO:0018279)3.58350077
61peptidyl-asparagine modification (GO:0018196)3.56964867
62response to endoplasmic reticulum stress (GO:0034976)3.55733173
63negative regulation of glycoprotein metabolic process (GO:1903019)3.53699588
64positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.50252270
65* regulation of peptide transport (GO:0090087)3.49857192
66epithelial cell fate commitment (GO:0072148)3.49472485
67inositol phosphate dephosphorylation (GO:0046855)3.48075063
68phosphorylated carbohydrate dephosphorylation (GO:0046838)3.48075063
69negative regulation of execution phase of apoptosis (GO:1900118)3.46237543
70glycerophospholipid catabolic process (GO:0046475)3.46046275
71axoneme assembly (GO:0035082)3.45568415
72regulation of autophagic vacuole assembly (GO:2000785)3.44846624
73response to unfolded protein (GO:0006986)3.42548098
74toxin metabolic process (GO:0009404)3.41601756
75negative regulation of peptide hormone secretion (GO:0090278)3.40488506
76negative regulation of bone resorption (GO:0045779)3.39908585
77protein localization to Golgi apparatus (GO:0034067)3.38985234
78negative regulation of hormone metabolic process (GO:0032351)3.36291750
79cellular response to glucagon stimulus (GO:0071377)3.35303072
80response to topologically incorrect protein (GO:0035966)3.34757272
81nodal signaling pathway (GO:0038092)3.32202833
82L-alpha-amino acid transmembrane transport (GO:1902475)3.30829126
83* response to hexose (GO:0009746)3.29648240
84regulation of oxidative phosphorylation (GO:0002082)3.28719321
85negative regulation of peptide secretion (GO:0002792)3.28242317
86protein N-linked glycosylation (GO:0006487)3.27285600
87regulation of glucocorticoid secretion (GO:2000849)3.26548836
88negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.24157918
89* response to glucose (GO:0009749)3.23217341
90peptide transport (GO:0015833)3.22902872
91hormone secretion (GO:0046879)3.21601026
92positive regulation of gluconeogenesis (GO:0045722)3.20271300
93regulation of acrosome reaction (GO:0060046)3.16078877
94respiratory chain complex IV assembly (GO:0008535)3.14715814
953-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.14530278
96purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.14530278
97calcium ion import (GO:0070509)3.14147443
98* response to monosaccharide (GO:0034284)3.12604168
99membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.12229259
100Golgi organization (GO:0007030)3.11678008
101response to hepatocyte growth factor (GO:0035728)3.11330311
102cellular response to hepatocyte growth factor stimulus (GO:0035729)3.11330311
103positive regulation of calcium ion import (GO:0090280)3.11116561
104astrocyte differentiation (GO:0048708)3.08782306
105macroautophagy (GO:0016236)3.06294440
106auditory receptor cell differentiation (GO:0042491)3.02552403
107hormone transport (GO:0009914)3.02001866
108chemosensory behavior (GO:0007635)3.01526121
109* positive regulation of hormone secretion (GO:0046887)3.00648589
110cytochrome complex assembly (GO:0017004)3.00003206
111glucose homeostasis (GO:0042593)2.99155556
112carbohydrate homeostasis (GO:0033500)2.99155556
113inner ear receptor cell development (GO:0060119)2.98818402
114positive regulation of glycolytic process (GO:0045821)2.98747084
115Golgi vesicle transport (GO:0048193)2.96163621
116lactate metabolic process (GO:0006089)2.95248959
117regulation of extracellular matrix disassembly (GO:0010715)2.92931782
118membrane repolarization during action potential (GO:0086011)2.92551526
119polyol catabolic process (GO:0046174)2.91739411
120cerebellar Purkinje cell layer development (GO:0021680)2.91432220
121cardiac left ventricle morphogenesis (GO:0003214)2.91413867
122somite development (GO:0061053)2.90070892
123regulation of vacuole organization (GO:0044088)2.89732211
124L-phenylalanine catabolic process (GO:0006559)2.88653081
125erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.88653081
126regulation of energy homeostasis (GO:2000505)2.87915695
127xenobiotic catabolic process (GO:0042178)2.87485886
128intestinal epithelial cell development (GO:0060576)2.87392747
129protein targeting to Golgi (GO:0000042)2.87141118
130magnesium ion transport (GO:0015693)2.85231181
131epithelial cilium movement (GO:0003351)2.84713681
132positive regulation of meiosis (GO:0045836)2.84086349
133catecholamine transport (GO:0051937)2.83747754
134phenylpropanoid metabolic process (GO:0009698)2.83467931
135regulation of calcium ion-dependent exocytosis (GO:0017158)2.77851965
136positive regulation of macroautophagy (GO:0016239)2.76775906
137establishment of protein localization to Golgi (GO:0072600)2.76403708
138zinc ion homeostasis (GO:0055069)2.75121184
139potassium ion export (GO:0071435)2.74960589
140nitric oxide biosynthetic process (GO:0006809)2.73536541
141L-phenylalanine metabolic process (GO:0006558)2.72044466
142erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.72044466
143negative regulation of protein oligomerization (GO:0032460)2.70670161
144positive regulation of histone H3-K4 methylation (GO:0051571)2.69800192
145retinol metabolic process (GO:0042572)2.69532374
146positive regulation of neurotransmitter transport (GO:0051590)2.69071975
147dopamine transport (GO:0015872)2.68456815
148cilium movement (GO:0003341)2.68409742
149regulation of heart rate by cardiac conduction (GO:0086091)2.65401159
150negative regulation of neurological system process (GO:0031645)2.65365988
151retrograde transport, vesicle recycling within Golgi (GO:0000301)2.64423475
152succinate metabolic process (GO:0006105)2.63008698
153positive regulation of meiotic cell cycle (GO:0051446)2.61957094
154nephron tubule morphogenesis (GO:0072078)2.61670519
155nephron epithelium morphogenesis (GO:0072088)2.61670519
156kidney morphogenesis (GO:0060993)2.61353500
157regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.61328812
158brain morphogenesis (GO:0048854)2.61139932
159sphingomyelin metabolic process (GO:0006684)2.58819282
160negative regulation of gluconeogenesis (GO:0045721)2.57421905
161negative regulation of glycogen metabolic process (GO:0070874)2.57354549
162COPI coating of Golgi vesicle (GO:0048205)10.8681624
163Golgi transport vesicle coating (GO:0048200)10.8681624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.72242619
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.59466799
3GATA1_22025678_ChIP-Seq_K562_Human3.94106377
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.93140691
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35872289
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.20039445
7REST_21632747_ChIP-Seq_MESCs_Mouse2.16833329
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10216082
9ZNF274_21170338_ChIP-Seq_K562_Hela2.05715613
10EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05135547
11PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.02714898
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92004262
13CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.79508062
14REST_18959480_ChIP-ChIP_MESCs_Mouse1.77811354
15NR3C1_23031785_ChIP-Seq_PC12_Mouse1.76930997
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74114148
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73659744
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73477638
19OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.66434146
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65453565
21SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63041167
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61603483
23HTT_18923047_ChIP-ChIP_STHdh_Human1.60962709
24SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.60789014
25REST_19997604_ChIP-ChIP_NEURONS_Mouse1.58497786
26P300_19829295_ChIP-Seq_ESCs_Human1.56967633
27FUS_26573619_Chip-Seq_HEK293_Human1.55275991
28FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.54184474
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54071163
30IGF1R_20145208_ChIP-Seq_DFB_Human1.53322502
31EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49956687
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48727923
33AR_25329375_ChIP-Seq_VCAP_Human1.47168931
34TFEB_21752829_ChIP-Seq_HELA_Human1.46855685
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45877489
36FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.45629904
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41354144
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41296148
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38597725
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38307415
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38254175
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38027554
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37906153
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.36915600
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36657720
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36555818
47P53_22387025_ChIP-Seq_ESCs_Mouse1.35893182
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34118747
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.32855975
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.32157803
51ER_23166858_ChIP-Seq_MCF-7_Human1.31115938
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.31096664
53CDX2_22108803_ChIP-Seq_LS180_Human1.29861848
54* TAF15_26573619_Chip-Seq_HEK293_Human1.29602217
55SOX2_18555785_Chip-Seq_ESCs_Mouse1.28846215
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28796633
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26583574
58TCF4_23295773_ChIP-Seq_U87_Human1.26024194
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25880301
60GBX2_23144817_ChIP-Seq_PC3_Human1.25878648
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.25653023
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25644870
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25581860
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25045022
65GATA1_19941826_ChIP-Seq_K562_Human1.24751174
66STAT3_18555785_Chip-Seq_ESCs_Mouse1.24155536
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21827717
68RARB_27405468_Chip-Seq_BRAIN_Mouse1.21737718
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.21437507
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20418541
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19114287
72STAT3_23295773_ChIP-Seq_U87_Human1.19076543
73VDR_22108803_ChIP-Seq_LS180_Human1.18562256
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.17820100
75CTCF_18555785_Chip-Seq_ESCs_Mouse1.17691157
76* FOXA1_25552417_ChIP-Seq_VCAP_Human1.16202390
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16104691
78AR_20517297_ChIP-Seq_VCAP_Human1.14965650
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14504737
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14079751
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13932635
82P300_18555785_Chip-Seq_ESCs_Mouse1.13039426
83SOX2_19829295_ChIP-Seq_ESCs_Human1.12821822
84NANOG_19829295_ChIP-Seq_ESCs_Human1.12821822
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12809271
86TP53_22573176_ChIP-Seq_HFKS_Human1.12472506
87TCF4_22108803_ChIP-Seq_LS180_Human1.12164107
88NMYC_18555785_Chip-Seq_ESCs_Mouse1.10535698
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.09916938
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.07527819
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07523476
92BCAT_22108803_ChIP-Seq_LS180_Human1.07150437
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.06790227
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06614863
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05878375
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05726442
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.05659229
98* RUNX2_22187159_ChIP-Seq_PCA_Human1.05536319
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05488644
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04073519
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02705467
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02634671
103LXR_22158963_ChIP-Seq_LIVER_Mouse1.02577967
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02462491
105FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.02030312
106GABP_17652178_ChIP-ChIP_JURKAT_Human1.01548350
107* SMAD3_21741376_ChIP-Seq_HESCs_Human1.01328818
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.00882529
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.00853264
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00837066
111PU1_27457419_Chip-Seq_LIVER_Mouse1.00071960
112ERG_20517297_ChIP-Seq_VCAP_Human0.99999594
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99968877
114FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99518395
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99374466
116TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99306905
117ZFX_18555785_Chip-Seq_ESCs_Mouse0.99196005
118CRX_20693478_ChIP-Seq_RETINA_Mouse0.98611079
119CBP_20019798_ChIP-Seq_JUKART_Human0.98471592
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98471592
121RXR_22158963_ChIP-Seq_LIVER_Mouse0.98075961
122EZH2_22144423_ChIP-Seq_EOC_Human0.97481869
123RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97258391
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.96998778
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96627918
126ESR1_21235772_ChIP-Seq_MCF-7_Human0.96135161
127EWS_26573619_Chip-Seq_HEK293_Human0.95570291
128FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95270049
129TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94974678
130CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94753358
131* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93501698
132PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92818867
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92502636
134GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92280314
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.86333815
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86249288
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84504192
138CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84259438
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83932768
140EZH2_27294783_Chip-Seq_ESCs_Mouse0.83361987
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81502173
142GATA3_27048872_Chip-Seq_THYMUS_Human0.81336884
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80813218
144MTF2_20144788_ChIP-Seq_MESCs_Mouse0.80206868
145DROSHA_22980978_ChIP-Seq_HELA_Human0.78257352
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.77627049
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77499683
148TET1_21490601_ChIP-Seq_MESCs_Mouse0.76170360
149ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76157766
150ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76123200
151RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75360479
152SMAD4_21799915_ChIP-Seq_A2780_Human0.75166443
153TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.74873999
154GATA3_26560356_Chip-Seq_TH2_Human0.74202141
155MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.74079210
156SOX2_20726797_ChIP-Seq_SW620_Human0.73349818
157FOXH1_21741376_ChIP-Seq_ESCs_Human0.73236497
158NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.72907719
159PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.72684022
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72593673
161CLOCK_20551151_ChIP-Seq_293T_Human0.72155710
162FOXA1_25329375_ChIP-Seq_VCAP_Human0.70735476
163FOXA1_27270436_Chip-Seq_PROSTATE_Human0.70735476
164CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70721378
165GF1B_26923725_Chip-Seq_HPCs_Mouse0.69874538
166SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69776991
167LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.69767161
168NANOG_18555785_Chip-Seq_ESCs_Mouse0.68959273

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.66244264
2MP0002877_abnormal_melanocyte_morpholog5.52444282
3MP0004043_abnormal_pH_regulation4.66634321
4* MP0002693_abnormal_pancreas_physiology4.45721401
5MP0009780_abnormal_chondrocyte_physiolo4.42241688
6MP0001944_abnormal_pancreas_morphology3.93341949
7MP0002909_abnormal_adrenal_gland3.83155013
8MP0000013_abnormal_adipose_tissue3.74147611
9MP0010386_abnormal_urinary_bladder3.70266773
10MP0005379_endocrine/exocrine_gland_phen3.34232192
11MP0010234_abnormal_vibrissa_follicle3.31844137
12MP0003195_calcinosis3.20247270
13MP0000678_abnormal_parathyroid_gland3.06323755
14MP0002837_dystrophic_cardiac_calcinosis3.01550132
15MP0003183_abnormal_peptide_metabolism3.01330840
16MP0003122_maternal_imprinting2.85348475
17MP0005220_abnormal_exocrine_pancreas2.73831584
18MP0006072_abnormal_retinal_apoptosis2.55745840
19* MP0002078_abnormal_glucose_homeostasis2.43154951
20MP0008877_abnormal_DNA_methylation2.33465380
21MP0009046_muscle_twitch2.28259419
22MP0001986_abnormal_taste_sensitivity2.04600436
23MP0005646_abnormal_pituitary_gland2.04525885
24MP0005645_abnormal_hypothalamus_physiol2.03294817
25MP0000003_abnormal_adipose_tissue1.99397508
26MP0004264_abnormal_extraembryonic_tissu1.98610629
27MP0010329_abnormal_lipoprotein_level1.76407234
28MP0003172_abnormal_lysosome_physiology1.74140435
29MP0000462_abnormal_digestive_system1.70584940
30MP0002928_abnormal_bile_duct1.68553484
31MP0002638_abnormal_pupillary_reflex1.65876315
32MP0005058_abnormal_lysosome_morphology1.63713299
33MP0004019_abnormal_vitamin_homeostasis1.61457915
34MP0004270_analgesia1.61329566
35MP0005332_abnormal_amino_acid1.57708766
36MP0008961_abnormal_basal_metabolism1.53610293
37MP0002822_catalepsy1.48249258
38* MP0003953_abnormal_hormone_level1.45319078
39MP0002896_abnormal_bone_mineralization1.42267162
40MP0001765_abnormal_ion_homeostasis1.41808209
41MP0002254_reproductive_system_inflammat1.36364885
42MP0003300_gastrointestinal_ulcer1.36046124
43MP0003959_abnormal_lean_body1.30485003
44MP0005310_abnormal_salivary_gland1.30102177
45MP0009643_abnormal_urine_homeostasis1.27388897
46MP0005551_abnormal_eye_electrophysiolog1.26121601
47MP0000631_abnormal_neuroendocrine_gland1.26080565
48MP0000613_abnormal_salivary_gland1.24453840
49MP0005535_abnormal_body_temperature1.20495716
50MP0002234_abnormal_pharynx_morphology1.20137383
51MP0004133_heterotaxia1.19478738
52MP0009745_abnormal_behavioral_response1.18839510
53MP0010678_abnormal_skin_adnexa1.17692863
54MP0001984_abnormal_olfaction1.16974610
55MP0002163_abnormal_gland_morphology1.15795792
56MP0004885_abnormal_endolymph1.15005752
57MP0001502_abnormal_circadian_rhythm1.14171449
58MP0003868_abnormal_feces_composition1.11627052
59MP0002876_abnormal_thyroid_physiology1.11184145
60MP0001501_abnormal_sleep_pattern1.09087408
61MP0002090_abnormal_vision1.06516057
62MP0000427_abnormal_hair_cycle1.04385315
63MP0002138_abnormal_hepatobiliary_system1.04324849
64MP0003252_abnormal_bile_duct1.04243897
65MP0005448_abnormal_energy_balance0.99201105
66MP0003119_abnormal_digestive_system0.98728382
67MP0002572_abnormal_emotion/affect_behav0.98535689
68MP0001905_abnormal_dopamine_level0.98414432
69MP0002064_seizures0.98120984
70MP0004510_myositis0.97903780
71MP0002272_abnormal_nervous_system0.97735132
72MP0002139_abnormal_hepatobiliary_system0.97453598
73MP0005084_abnormal_gallbladder_morpholo0.96047114
74MP0005257_abnormal_intraocular_pressure0.94733071
75MP0003633_abnormal_nervous_system0.94075816
76MP0001270_distended_abdomen0.91071644
77MP0005636_abnormal_mineral_homeostasis0.90057365
78MP0003890_abnormal_embryonic-extraembry0.88652888
79MP0005075_abnormal_melanosome_morpholog0.88570279
80MP0005386_behavior/neurological_phenoty0.86838737
81MP0004924_abnormal_behavior0.86838737
82MP0005253_abnormal_eye_physiology0.86772494
83MP0002733_abnormal_thermal_nociception0.86087257
84MP0009672_abnormal_birth_weight0.86011618
85MP0001764_abnormal_homeostasis0.85400310
86MP0004085_abnormal_heartbeat0.84199924
87MP0003787_abnormal_imprinting0.84017551
88MP0003011_delayed_dark_adaptation0.83138045
89MP0001756_abnormal_urination0.81063970
90MP0000538_abnormal_urinary_bladder0.80526978
91MP0000639_abnormal_adrenal_gland0.79962285
92MP0008875_abnormal_xenobiotic_pharmacok0.79471070
93* MP0002557_abnormal_social/conspecific_i0.79374597
94MP0005375_adipose_tissue_phenotype0.78932862
95MP0005365_abnormal_bile_salt0.77062431
96MP0000230_abnormal_systemic_arterial0.76009905
97MP0000681_abnormal_thyroid_gland0.75372860
98MP0001299_abnormal_eye_distance/0.74945513
99MP0002938_white_spotting0.74780087
100MP0001661_extended_life_span0.74292123
101MP0006054_spinal_hemorrhage0.73705277
102MP0005187_abnormal_penis_morphology0.71693529
103MP0005248_abnormal_Harderian_gland0.71574989
104MP0004142_abnormal_muscle_tone0.69618785
105MP0002118_abnormal_lipid_homeostasis0.69526488
106MP0002168_other_aberrant_phenotype0.68042418
107MP0004145_abnormal_muscle_electrophysio0.67887681
108MP0005389_reproductive_system_phenotype0.66466422
109MP0001968_abnormal_touch/_nociception0.65845242
110MP0003866_abnormal_defecation0.62677536
111MP0009703_decreased_birth_body0.61520598
112MP0004147_increased_porphyrin_level0.61450241
113MP0008872_abnormal_physiological_respon0.61329549
114MP0003123_paternal_imprinting0.60663911
115MP0001666_abnormal_nutrient_absorption0.60120494
116MP0002063_abnormal_learning/memory/cond0.59591445
117* MP0009642_abnormal_blood_homeostasis0.59241518
118MP0005334_abnormal_fat_pad0.59183308
119MP0000516_abnormal_urinary_system0.58548963
120MP0005367_renal/urinary_system_phenotyp0.58548963
121MP0000383_abnormal_hair_follicle0.57667079
122MP0002069_abnormal_eating/drinking_beha0.57513335
123MP0003879_abnormal_hair_cell0.56601390
124MP0003121_genomic_imprinting0.56160949
125MP0005452_abnormal_adipose_tissue0.54390463
126MP0003045_fibrosis0.52808419
127MP0000955_abnormal_spinal_cord0.51819530
128MP0002734_abnormal_mechanical_nocicepti0.50956248
129MP0001970_abnormal_pain_threshold0.50648796
130MP0003329_amyloid_beta_deposits0.50406025
131MP0001731_abnormal_postnatal_growth0.48857585
132MP0003795_abnormal_bone_structure0.48542591
133MP0005408_hypopigmentation0.45593675
134MP0006276_abnormal_autonomic_nervous0.45017078
135MP0002970_abnormal_white_adipose0.43733495
136MP0001186_pigmentation_phenotype0.43259187
137MP0002229_neurodegeneration0.43194233
138MP0004036_abnormal_muscle_relaxation0.42798299
139MP0006036_abnormal_mitochondrial_physio0.39920174
140MP0003634_abnormal_glial_cell0.38673920
141MP0002177_abnormal_outer_ear0.37837193
142MP0001664_abnormal_digestion0.37610877
143MP0000163_abnormal_cartilage_morphology0.37509531
144MP0002269_muscular_atrophy0.35845903

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.55347243
2Hypoglycemic seizures (HP:0002173)8.01265492
3Symptomatic seizures (HP:0011145)7.25317266
4Hypoglycemic coma (HP:0001325)6.95007277
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.85576843
6Insulin-resistant diabetes mellitus (HP:0000831)5.42723184
7Hyperglycemia (HP:0003074)4.85163660
8Abnormality of endocrine pancreas physiology (HP:0012093)4.67008333
9Abnormality of the pancreatic islet cells (HP:0006476)4.67008333
10Pancreatic islet-cell hyperplasia (HP:0004510)4.45991928
11Abnormal pancreas size (HP:0012094)4.42336299
12Abnormality of calcium-phosphate metabolism (HP:0100530)4.39359184
13Ketoacidosis (HP:0001993)4.32830586
14Large for gestational age (HP:0001520)4.17939787
15Decreased circulating renin level (HP:0003351)4.12712998
16Late onset (HP:0003584)4.08362720
17Urinary glycosaminoglycan excretion (HP:0003541)4.00269222
18Mucopolysacchariduria (HP:0008155)4.00269222
19Dysostosis multiplex (HP:0000943)3.82724995
20Generalized aminoaciduria (HP:0002909)3.82145634
21Double outlet right ventricle (HP:0001719)3.80993956
22Congenital malformation of the right heart (HP:0011723)3.80993956
23Abnormality of polysaccharide metabolism (HP:0011012)3.66822321
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.66822321
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.66822321
26Abnormality of the intrinsic pathway (HP:0010989)3.40150918
27Hypokalemia (HP:0002900)3.39785658
28Menstrual irregularities (HP:0000858)3.23693267
29Osteomalacia (HP:0002749)3.22543231
30Insulin resistance (HP:0000855)3.22399701
31Agitation (HP:0000713)3.15070547
32Enlarged penis (HP:0000040)2.96461151
33Abnormality of vitamin B metabolism (HP:0004340)2.89552016
34Hypomagnesemia (HP:0002917)2.85256330
35Abnormality of aromatic amino acid family metabolism (HP:0004338)2.85031438
36Hyperparathyroidism (HP:0000843)2.75426426
37Hemiparesis (HP:0001269)2.73288897
38Hypothermia (HP:0002045)2.73218799
39Increased CSF protein (HP:0002922)2.68319693
40Limb hypertonia (HP:0002509)2.68260631
41Abnormality of renin-angiotensin system (HP:0000847)2.64659989
42Abnormality of vitamin metabolism (HP:0100508)2.62268258
43Prominent metopic ridge (HP:0005487)2.62010747
44Abnormality of potassium homeostasis (HP:0011042)2.56306595
45Growth hormone excess (HP:0000845)2.52515639
46Thoracolumbar scoliosis (HP:0002944)2.50812178
47Unilateral renal agenesis (HP:0000122)2.49294886
48Hyperactive renin-angiotensin system (HP:0000841)2.49101320
49Hyperthyroidism (HP:0000836)2.45726522
50Oligomenorrhea (HP:0000876)2.43614703
51Ketosis (HP:0001946)2.43589438
52Visual hallucinations (HP:0002367)2.41133391
53Pancreatic fibrosis (HP:0100732)2.38926751
54Papilledema (HP:0001085)2.38574917
55Hypercortisolism (HP:0001578)2.35666068
56EEG with generalized epileptiform discharges (HP:0011198)2.35116492
57Hypsarrhythmia (HP:0002521)2.33297439
58Conjugated hyperbilirubinemia (HP:0002908)2.31907406
59Chronic bronchitis (HP:0004469)2.31287774
60Pancreatic cysts (HP:0001737)2.30773955
61Abnormality of magnesium homeostasis (HP:0004921)2.30636958
62Polydipsia (HP:0001959)2.28864390
63Abnormal drinking behavior (HP:0030082)2.28864390
64Exocrine pancreatic insufficiency (HP:0001738)2.28817212
65Progressive neurologic deterioration (HP:0002344)2.27468919
66Hyperkalemia (HP:0002153)2.25145750
67Methylmalonic acidemia (HP:0002912)2.24553130
68Epileptiform EEG discharges (HP:0011182)2.23498004
69Muscular hypotonia of the trunk (HP:0008936)2.21903830
70Hematochezia (HP:0002573)2.20918040
71Pheochromocytoma (HP:0002666)2.20642019
72Abnormality of the metopic suture (HP:0005556)2.19862790
73Abdominal distention (HP:0003270)2.17495541
74Dysautonomia (HP:0002459)2.17191442
75Gout (HP:0001997)2.15445184
76Abnormality of the renal cortex (HP:0011035)2.12529073
77Hypophosphatemia (HP:0002148)2.10634670
78Hypoalbuminemia (HP:0003073)2.10326554
79Abnormal albumin level (HP:0012116)2.10326554
80Failure to thrive in infancy (HP:0001531)2.09866376
81Testicular neoplasm (HP:0010788)2.07894747
82Neoplasm of the adrenal cortex (HP:0100641)2.06903262
83Retinal atrophy (HP:0001105)2.06875880
84Aplasia/hypoplasia of the uterus (HP:0008684)2.05615862
85Nephronophthisis (HP:0000090)2.05511465
86Abnormal respiratory epithelium morphology (HP:0012253)2.05332186
87Abnormal respiratory motile cilium morphology (HP:0005938)2.05332186
88Cortical visual impairment (HP:0100704)2.02431785
89Abnormal protein glycosylation (HP:0012346)2.02108841
90Abnormal glycosylation (HP:0012345)2.02108841
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02108841
92Abnormal protein N-linked glycosylation (HP:0012347)2.02108841
93Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00981452
94Abnormal sex determination (HP:0012244)2.00827509
95Sex reversal (HP:0012245)2.00827509
96Hyperventilation (HP:0002883)2.00511967
97Abnormality of liposaccharide metabolism (HP:0010968)1.99466456
98Abnormality of glycosphingolipid metabolism (HP:0004343)1.99466456
99Abnormality of glycolipid metabolism (HP:0010969)1.99466456
100Abnormal ciliary motility (HP:0012262)1.99223061
101Ventricular fibrillation (HP:0001663)1.98687884
102Abnormality of the fovea (HP:0000493)1.98454472
103Rhinitis (HP:0012384)1.98378478
104Hypokalemic alkalosis (HP:0001949)1.98285317
105Gaze-evoked nystagmus (HP:0000640)1.98001412
106Abnormal rod and cone electroretinograms (HP:0008323)1.96961206
107Acute hepatic failure (HP:0006554)1.96350099
108Molar tooth sign on MRI (HP:0002419)1.96187369
109Abnormality of midbrain morphology (HP:0002418)1.96187369
110Protuberant abdomen (HP:0001538)1.95853484
111Vascular calcification (HP:0004934)1.95453321
112Abnormality of the common coagulation pathway (HP:0010990)1.95401360
113Restlessness (HP:0000711)1.94507520
114Hyperphosphaturia (HP:0003109)1.94345855
115Glucose intolerance (HP:0000833)1.92485491
116Medial flaring of the eyebrow (HP:0010747)1.91754258
117Nuclear cataract (HP:0100018)1.91719196
118Hypokinesia (HP:0002375)1.91306022
119Progressive macrocephaly (HP:0004481)1.90516225
120Macroorchidism (HP:0000053)1.90442727
121Hyperphosphatemia (HP:0002905)1.89683129
122Conjunctival hamartoma (HP:0100780)1.88842388
123Neoplasm of the adrenal gland (HP:0100631)1.87373246
124Proximal tubulopathy (HP:0000114)1.86906546
125Hypoplasia of the fovea (HP:0007750)1.86704889
126Aplasia/Hypoplasia of the fovea (HP:0008060)1.86704889
127Postural tremor (HP:0002174)1.86608557
128Neuroendocrine neoplasm (HP:0100634)1.84834225
129Irregular vertebral endplates (HP:0003301)1.84144331
130Hyperaldosteronism (HP:0000859)1.83204569
131Adrenal overactivity (HP:0002717)1.81820779
132Furrowed tongue (HP:0000221)1.81314805
133Abnormality of purine metabolism (HP:0004352)1.81117768
134Zonular cataract (HP:0010920)1.80735274
135Vacuolated lymphocytes (HP:0001922)1.79109547
136Myoglobinuria (HP:0002913)1.78818576
137True hermaphroditism (HP:0010459)1.77439799
138Glycosuria (HP:0003076)1.76864769
139Abnormality of urine glucose concentration (HP:0011016)1.76864769
140Abnormality of the renal medulla (HP:0100957)1.76400687
141Decreased subcutaneous fat (HP:0001002)1.75791014
142Abnormal respiratory motile cilium physiology (HP:0012261)1.75563947
143Hamartoma of the eye (HP:0010568)1.73872456
144Hypotension (HP:0002615)1.73833331
145Increased circulating renin level (HP:0000848)1.71918524
146Congenital glaucoma (HP:0001087)1.70669596
147Generalized hyperpigmentation (HP:0007440)1.70570366
148Elevated alkaline phosphatase (HP:0003155)1.68981075
149Intestinal atresia (HP:0011100)1.68718720
150Broad face (HP:0000283)1.62043012
151Missing ribs (HP:0000921)1.61721629
152Abnormality of chloride homeostasis (HP:0011422)1.61230343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR8.30530246
2PASK7.10532676
3MAPK153.63148845
4PHKG23.59341683
5PHKG13.59341683
6MST43.31153108
7TAOK33.27772505
8PRKD33.25379712
9FGFR23.24275036
10HIPK23.19426368
11DAPK22.87241646
12MAP2K62.75434285
13MAP3K22.72874826
14FRK2.70440003
15ERN12.50922668
16GRK12.26539890
17FLT32.18115267
18NTRK31.97692813
19MAP4K21.89248241
20NTRK11.85535260
21FGFR31.84526589
22ACVR1B1.84250657
23MAP3K41.79234464
24CASK1.75690796
25CSNK1G11.72189045
26ADRBK21.70732101
27CAMKK21.69927033
28MAP3K11.67150806
29TNIK1.60319729
30CSNK1G31.60102300
31WNK41.53772993
32SCYL21.53380331
33STK31.45631560
34PTK21.45532973
35CSNK1G21.43631271
36TRPM71.42408529
37CDC42BPA1.40525941
38STK38L1.38787272
39IRAK31.38604681
40UHMK11.37953494
41PDGFRA1.35315181
42PINK11.24932737
43MAP3K121.23883257
44AKT31.20755390
45MET1.17462179
46PAK31.13815174
47TAOK11.11205664
48PRKCH1.10718840
49TRIB31.10713542
50PTK61.10604628
51BRSK21.08753645
52EIF2AK31.02563282
53GRK71.00875077
54BCKDK1.00693559
55IRAK10.99661886
56BRAF0.98611128
57MAP3K90.97517937
58MAP2K20.92047029
59PRKD20.91845742
60PRKAA20.90682833
61IRAK20.85764825
62MKNK20.84977394
63STK390.84703757
64OXSR10.81501716
65PLK20.79657672
66TNK20.79133122
67DYRK1B0.75626361
68BRD40.74664390
69STK40.74095551
70STK240.72090298
71STK110.67441619
72PTK2B0.65505233
73EPHA30.61045550
74ITK0.60314547
75PRKCE0.60242340
76JAK20.58914645
77SIK10.58110683
78RET0.58107119
79DAPK10.57989203
80PNCK0.57402885
81CSNK1A1L0.57204833
82BMPR20.57111028
83RPS6KA20.55031077
84MAP2K40.52281817
85BCR0.51763691
86PRKG10.51484957
87MAP2K70.51157848
88PRKAA10.50302843
89CAMKK10.49911735
90PRKCI0.49380103
91WNK10.48517504
92STK380.47185137
93ZAP700.46959978
94CDK50.46254646
95CAMK2D0.46147197
96PRKACG0.45805653
97JAK30.44808479
98KSR20.44569896
99GSK3A0.39667840
100PIK3CG0.39614229
101ADRBK10.39383164
102FER0.38247198
103WNK30.38071658
104CSNK1A10.37015899
105ZAK0.36898444
106RPS6KB10.34953137
107SGK30.34950344
108IRAK40.34938254
109MAP3K30.34355180
110BMPR1B0.34317051
111PRKACA0.34098165
112NUAK10.33953557
113NLK0.33773059
114PRKD10.33701982
115BRSK10.32551267
116CSNK1E0.32171860
117CAMK2A0.31181406
118IGF1R0.30897098
119VRK10.30577484
120CSNK1D0.30286904
121NEK60.29853623
122CAMK1G0.29851117
123MARK20.29256019
124CAMK2B0.28208707
125CAMK2G0.27670616
126JAK10.26877571
127PRKACB0.26752993
128LIMK10.25829505
129PRKDC0.25526381
130STK160.25023843
131TEC0.24112226
132MYLK0.23932459
133PRKCZ0.23695635
134PLK30.23043652
135PRKCG0.22532164
136OBSCN0.22347155
137PRKCB0.21923937
138PRKCA0.21580725
139MTOR0.21373794
140PDGFRB0.21193464
141PRKCQ0.20802711
142MAPK100.20662588
143MAPK140.20413140
144CHUK0.19919627
145SGK4940.19641206
146SGK2230.19641206
147RPS6KA30.19108758
148SGK20.19030162
149SGK10.18840524
150ARAF0.18603198
151ERBB30.18537520
152GRK50.17139686
153AKT10.17024582
154MAP2K10.16875938
155PAK60.16781279
156PDPK10.16136537

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.36755032
2Protein export_Homo sapiens_hsa030605.51613927
3Sulfur metabolism_Homo sapiens_hsa009203.58178781
4Insulin secretion_Homo sapiens_hsa049113.42213557
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.03278241
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51782005
7Type II diabetes mellitus_Homo sapiens_hsa049302.39857614
8Vibrio cholerae infection_Homo sapiens_hsa051102.27099315
9Type I diabetes mellitus_Homo sapiens_hsa049402.12120052
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.06885599
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82901900
12Selenocompound metabolism_Homo sapiens_hsa004501.80910515
13Vitamin B6 metabolism_Homo sapiens_hsa007501.76388785
14Cocaine addiction_Homo sapiens_hsa050301.72424754
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64888509
16Oxidative phosphorylation_Homo sapiens_hsa001901.62197887
17N-Glycan biosynthesis_Homo sapiens_hsa005101.55842896
18Lysosome_Homo sapiens_hsa041421.50767068
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.48352077
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39901946
21Amphetamine addiction_Homo sapiens_hsa050311.30861008
22Other glycan degradation_Homo sapiens_hsa005111.29134429
23beta-Alanine metabolism_Homo sapiens_hsa004101.27252046
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26998697
25Peroxisome_Homo sapiens_hsa041461.23149665
26Taste transduction_Homo sapiens_hsa047421.20256908
27Mineral absorption_Homo sapiens_hsa049781.16727031
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14773523
29Collecting duct acid secretion_Homo sapiens_hsa049661.14477829
30Phototransduction_Homo sapiens_hsa047441.13055415
31Regulation of autophagy_Homo sapiens_hsa041401.09794489
32Glucagon signaling pathway_Homo sapiens_hsa049221.07453249
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02922799
34Galactose metabolism_Homo sapiens_hsa000521.01265146
35Ether lipid metabolism_Homo sapiens_hsa005651.00742923
36Propanoate metabolism_Homo sapiens_hsa006401.00443277
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99950478
38Insulin resistance_Homo sapiens_hsa049310.99826477
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99201654
40Tryptophan metabolism_Homo sapiens_hsa003800.97778498
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96948576
42Folate biosynthesis_Homo sapiens_hsa007900.96567848
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94836588
44Pancreatic secretion_Homo sapiens_hsa049720.93424973
45Circadian rhythm_Homo sapiens_hsa047100.92659855
46Thyroid hormone synthesis_Homo sapiens_hsa049180.91849613
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91835474
48Synaptic vesicle cycle_Homo sapiens_hsa047210.91032535
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88772661
50Long-term potentiation_Homo sapiens_hsa047200.87820530
51Prolactin signaling pathway_Homo sapiens_hsa049170.85430538
52Butanoate metabolism_Homo sapiens_hsa006500.84385613
53Dopaminergic synapse_Homo sapiens_hsa047280.84241481
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83983505
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83456989
56Prion diseases_Homo sapiens_hsa050200.82747080
57ABC transporters_Homo sapiens_hsa020100.80394759
58Cardiac muscle contraction_Homo sapiens_hsa042600.79378232
59Retinol metabolism_Homo sapiens_hsa008300.77429297
60Nitrogen metabolism_Homo sapiens_hsa009100.76804056
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75296638
62Sphingolipid metabolism_Homo sapiens_hsa006000.73146512
63Circadian entrainment_Homo sapiens_hsa047130.72485677
64Phenylalanine metabolism_Homo sapiens_hsa003600.72354277
65Parkinsons disease_Homo sapiens_hsa050120.70776546
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.70694348
67Cholinergic synapse_Homo sapiens_hsa047250.70619894
68Chemical carcinogenesis_Homo sapiens_hsa052040.70097818
69Alzheimers disease_Homo sapiens_hsa050100.69651818
70Starch and sucrose metabolism_Homo sapiens_hsa005000.69414168
71GABAergic synapse_Homo sapiens_hsa047270.68737008
72Glutathione metabolism_Homo sapiens_hsa004800.66699850
73Serotonergic synapse_Homo sapiens_hsa047260.65906929
74Arginine biosynthesis_Homo sapiens_hsa002200.64970256
75Fatty acid metabolism_Homo sapiens_hsa012120.64772722
76Salivary secretion_Homo sapiens_hsa049700.64019354
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62758995
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62703263
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62181779
80Caffeine metabolism_Homo sapiens_hsa002320.60734227
81Estrogen signaling pathway_Homo sapiens_hsa049150.60007641
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59155669
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58258071
84Insulin signaling pathway_Homo sapiens_hsa049100.57452302
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55383650
86Histidine metabolism_Homo sapiens_hsa003400.55159792
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54132946
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53757471
89Metabolic pathways_Homo sapiens_hsa011000.53494271
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.52951462
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.49882164
92Thyroid cancer_Homo sapiens_hsa052160.48200004
93Arachidonic acid metabolism_Homo sapiens_hsa005900.48089009
94Fatty acid elongation_Homo sapiens_hsa000620.46549017
95Morphine addiction_Homo sapiens_hsa050320.45169137
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.44067264
97Alcoholism_Homo sapiens_hsa050340.43983944
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42658704
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40746653
100Huntingtons disease_Homo sapiens_hsa050160.40452841
101Linoleic acid metabolism_Homo sapiens_hsa005910.39898888
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38571213
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37863794
104Renin secretion_Homo sapiens_hsa049240.35482756
105Lysine degradation_Homo sapiens_hsa003100.35423353
106cAMP signaling pathway_Homo sapiens_hsa040240.35229788
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35074005
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32306966
109Tyrosine metabolism_Homo sapiens_hsa003500.32216010
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30670271
111mTOR signaling pathway_Homo sapiens_hsa041500.30372576
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30127335
113AMPK signaling pathway_Homo sapiens_hsa041520.28387177
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27218672
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26212175
116Prostate cancer_Homo sapiens_hsa052150.24358519
117Fat digestion and absorption_Homo sapiens_hsa049750.23247912
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22900558
119Phagosome_Homo sapiens_hsa041450.22641330
120Dorso-ventral axis formation_Homo sapiens_hsa043200.22596271
121Ovarian steroidogenesis_Homo sapiens_hsa049130.21693529
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21399906
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.21118875
124Melanogenesis_Homo sapiens_hsa049160.20659526
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18584193
126Inositol phosphate metabolism_Homo sapiens_hsa005620.18504819
127Antigen processing and presentation_Homo sapiens_hsa046120.18324393
128Glutamatergic synapse_Homo sapiens_hsa047240.17917687
129Bladder cancer_Homo sapiens_hsa052190.17500626
130Gastric acid secretion_Homo sapiens_hsa049710.16595544
131Protein digestion and absorption_Homo sapiens_hsa049740.15932707
132Fatty acid degradation_Homo sapiens_hsa000710.15720934
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.15382046
134FoxO signaling pathway_Homo sapiens_hsa040680.15004469
135Long-term depression_Homo sapiens_hsa047300.14862442
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14840883
137GnRH signaling pathway_Homo sapiens_hsa049120.12192892
138Rheumatoid arthritis_Homo sapiens_hsa053230.10873573

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »