UCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid transmembrane transport (GO:1902001)9.60447943
2regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)8.97505040
3tricarboxylic acid cycle (GO:0006099)8.91428606
4biotin metabolic process (GO:0006768)8.82270447
5NADH metabolic process (GO:0006734)8.58849918
6regulation of acyl-CoA biosynthetic process (GO:0050812)8.24490205
7carnitine transmembrane transport (GO:1902603)8.14187438
8regulation of fatty acid oxidation (GO:0046320)7.99179663
9fatty acid beta-oxidation (GO:0006635)7.77439385
10regulation of cofactor metabolic process (GO:0051193)7.76741588
11regulation of coenzyme metabolic process (GO:0051196)7.76741588
12diacylglycerol metabolic process (GO:0046339)7.56774929
13amino-acid betaine transport (GO:0015838)7.48935659
14carnitine transport (GO:0015879)7.48935659
15positive regulation of fatty acid oxidation (GO:0046321)6.96787238
16positive regulation of fatty acid beta-oxidation (GO:0032000)6.90019354
17fatty acid catabolic process (GO:0009062)6.50882770
18fatty acid oxidation (GO:0019395)6.48945815
19lipid oxidation (GO:0034440)6.38310817
20acetyl-CoA metabolic process (GO:0006084)6.34898955
21linoleic acid metabolic process (GO:0043651)6.28464238
22regulation of sulfur metabolic process (GO:0042762)6.21962152
23plasma lipoprotein particle clearance (GO:0034381)5.99757501
24intracellular lipid transport (GO:0032365)5.87287927
25phospholipid homeostasis (GO:0055091)5.84166656
26L-serine transport (GO:0015825)5.81052233
27thioester biosynthetic process (GO:0035384)5.79585788
28acyl-CoA biosynthetic process (GO:0071616)5.79585788
29succinate metabolic process (GO:0006105)5.73999451
30CDP-diacylglycerol biosynthetic process (GO:0016024)5.67893527
31coenzyme A biosynthetic process (GO:0015937)5.61451894
32triglyceride catabolic process (GO:0019433)5.60450041
33quaternary ammonium group transport (GO:0015697)5.52782297
34regulation of fatty acid beta-oxidation (GO:0031998)5.47285556
35branched-chain amino acid catabolic process (GO:0009083)5.45191245
36triglyceride biosynthetic process (GO:0019432)5.32164301
37white fat cell differentiation (GO:0050872)5.25429052
38lipid particle organization (GO:0034389)5.23627825
39lipid storage (GO:0019915)5.23341179
40CDP-diacylglycerol metabolic process (GO:0046341)5.19790121
41neutral lipid catabolic process (GO:0046461)5.10260349
42acylglycerol catabolic process (GO:0046464)5.10260349
43acylglycerol biosynthetic process (GO:0046463)5.07864025
44neutral lipid biosynthetic process (GO:0046460)5.07864025
45regulation of glycogen (starch) synthase activity (GO:2000465)5.06258447
46lysine catabolic process (GO:0006554)5.05675594
47lysine metabolic process (GO:0006553)5.05675594
48fatty-acyl-CoA biosynthetic process (GO:0046949)5.05562295
49proline transport (GO:0015824)5.04516671
50tricarboxylic acid metabolic process (GO:0072350)5.02305253
51serine transport (GO:0032329)5.01838908
52glycine transport (GO:0015816)4.97673174
53monocarboxylic acid catabolic process (GO:0072329)4.96768240
54valine metabolic process (GO:0006573)4.93348090
55* brown fat cell differentiation (GO:0050873)4.89905929
56positive regulation of cholesterol efflux (GO:0010875)4.88671409
57short-chain fatty acid metabolic process (GO:0046459)4.88503864
58positive regulation of lipid storage (GO:0010884)4.85728371
59branched-chain amino acid metabolic process (GO:0009081)4.85406275
60regulation of triglyceride catabolic process (GO:0010896)4.80671892
61negative regulation of fatty acid biosynthetic process (GO:0045717)4.75171790
62cardiolipin metabolic process (GO:0032048)4.64291779
63alanine transport (GO:0032328)4.62798084
64fatty-acyl-CoA metabolic process (GO:0035337)4.62558213
65carnitine metabolic process (GO:0009437)4.61141854
66low-density lipoprotein particle clearance (GO:0034383)4.59749806
67ethanol oxidation (GO:0006069)4.54464536
68coenzyme A metabolic process (GO:0015936)4.49249920
69glycerol metabolic process (GO:0006071)4.45302451
70regulation of cholesterol storage (GO:0010885)4.39725928
71regulation of cAMP-dependent protein kinase activity (GO:2000479)4.37199946
72oxaloacetate metabolic process (GO:0006107)4.35763867
73regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.34884082
74retinol metabolic process (GO:0042572)4.34487645
75positive regulation of lipid catabolic process (GO:0050996)4.33711759
76negative regulation of fatty acid metabolic process (GO:0045922)4.31572230
77positive regulation of cholesterol transport (GO:0032376)4.29026072
78positive regulation of sterol transport (GO:0032373)4.29026072
79acyl-CoA metabolic process (GO:0006637)4.24103694
80thioester metabolic process (GO:0035383)4.24103694
81long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.21530120
82response to gravity (GO:0009629)4.15285343
83primary alcohol metabolic process (GO:0034308)4.12055236
84regulation of fatty acid metabolic process (GO:0019217)4.10503636
85long-chain fatty acid transport (GO:0015909)4.05374623
86phosphatidic acid metabolic process (GO:0046473)4.01518506
87phosphatidic acid biosynthetic process (GO:0006654)4.01518506
88positive regulation of glycolytic process (GO:0045821)4.00866002
89negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.95358415
90alditol metabolic process (GO:0019400)3.89617799
91coenzyme catabolic process (GO:0009109)3.87201482
92long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.86197459
93regulation of lipid storage (GO:0010883)3.85358582
94glycerolipid catabolic process (GO:0046503)3.81651808
95negative regulation of lipid storage (GO:0010888)3.80190826
96cellular lipid catabolic process (GO:0044242)3.80032509
97triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.72627374
98cellular response to lithium ion (GO:0071285)3.72480047
99ethanol metabolic process (GO:0006067)3.71143857
100triglyceride metabolic process (GO:0006641)3.70491078
101positive regulation of fatty acid metabolic process (GO:0045923)3.70033884
102* respiratory electron transport chain (GO:0022904)3.68980285
103regulation of triglyceride metabolic process (GO:0090207)3.67485426
104negative regulation of lipid catabolic process (GO:0050995)3.64636345
105temperature homeostasis (GO:0001659)3.63812784
106* electron transport chain (GO:0022900)3.59185505
107fatty acid elongation (GO:0030497)3.56478591
108regulation of triglyceride biosynthetic process (GO:0010866)3.54803379
109mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.54744757
110acylglycerol metabolic process (GO:0006639)3.51016754
111peroxisome fission (GO:0016559)3.50986756
112regulation of lipid catabolic process (GO:0050994)3.50325581
113pentose-phosphate shunt (GO:0006098)3.49114428
114cholesterol biosynthetic process (GO:0006695)3.48422102
115amino-acid betaine metabolic process (GO:0006577)3.47405495
116response to phenylpropanoid (GO:0080184)3.46832617
117neutral lipid metabolic process (GO:0006638)3.46542259
118fatty acid transport (GO:0015908)3.45180009
119regulation of cholesterol efflux (GO:0010874)3.42814415
120purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.42583497
121ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.42583497
122nucleoside bisphosphate biosynthetic process (GO:0033866)3.42583497
123triglyceride homeostasis (GO:0070328)3.42009649
124acylglycerol homeostasis (GO:0055090)3.42009649
125protein heterotrimerization (GO:0070208)3.41263408
126regulation of macrophage derived foam cell differentiation (GO:0010743)3.39250680
127regulation of cholesterol biosynthetic process (GO:0045540)3.38876292
128positive regulation of glomerulus development (GO:0090193)3.38540904
129cellular response to epinephrine stimulus (GO:0071872)3.37227356
130positive regulation of triglyceride metabolic process (GO:0090208)3.36120070
131regulation of cholesterol metabolic process (GO:0090181)3.35472071
132NADPH regeneration (GO:0006740)3.34197627
133aspartate family amino acid catabolic process (GO:0009068)3.31613643
134pantothenate metabolic process (GO:0015939)3.31161402
135alpha-linolenic acid metabolic process (GO:0036109)3.28564231
136negative regulation of lipase activity (GO:0060192)3.26818158
137very long-chain fatty acid metabolic process (GO:0000038)3.22546916
138negative regulation of metanephros development (GO:0072217)3.21795984
139sterol biosynthetic process (GO:0016126)3.10071616
140negative regulation of macrophage differentiation (GO:0045650)3.09710845
141negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.03132621
142regulation of sequestering of triglyceride (GO:0010889)11.3696751
143fatty acid homeostasis (GO:0055089)11.0454360
144carnitine shuttle (GO:0006853)10.5924820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse8.24017407
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.09064651
3EZH2_22144423_ChIP-Seq_EOC_Human4.04371707
4CLOCK_20551151_ChIP-Seq_293T_Human3.78480688
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.35764584
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.25736212
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.04183353
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.61345408
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.55995542
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.45909526
11ZNF263_19887448_ChIP-Seq_K562_Human2.32977812
12PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.16705604
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14454347
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.03227491
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02135495
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01015021
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse16.0985590
18PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.96766512
19PPAR_26484153_Chip-Seq_NCI-H1993_Human1.89113434
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69463113
21PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.68145147
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63773618
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54742710
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47107577
25HTT_18923047_ChIP-ChIP_STHdh_Human1.41041325
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36258023
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.32204288
28EOMES_21245162_ChIP-Seq_HESCs_Human1.30508429
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29424052
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.28165771
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27793101
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.26592346
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24946045
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23885688
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.22060308
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21882718
37RXR_22108803_ChIP-Seq_LS180_Human1.17796805
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17694653
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.17411603
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14086863
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13545153
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12263558
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.06386144
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.06327801
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.06327801
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04563761
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04563761
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02742818
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.01560304
50BCAT_22108803_ChIP-Seq_LS180_Human0.97178579
51TP53_20018659_ChIP-ChIP_R1E_Mouse0.96109159
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95755684
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94848187
54HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93813717
55CBP_20019798_ChIP-Seq_JUKART_Human0.92931095
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92931095
57WT1_19549856_ChIP-ChIP_CCG9911_Human0.92796471
58FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92576397
59CBX2_27304074_Chip-Seq_ESCs_Mouse0.92506035
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91642409
61TRIM28_21343339_ChIP-Seq_HEK293_Human0.91610512
62GBX2_23144817_ChIP-Seq_PC3_Human0.91441014
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90969622
64* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88956559
65GATA1_22025678_ChIP-Seq_K562_Human0.88708064
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87982723
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87230516
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87075185
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86468836
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86403990
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86140135
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84919539
73IGF1R_20145208_ChIP-Seq_DFB_Human0.84175729
74RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83207786
75CBP_21632823_ChIP-Seq_H3396_Human0.83089987
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81937552
77FOXA2_19822575_ChIP-Seq_HepG2_Human0.81681430
78NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81553839
79EGR1_19032775_ChIP-ChIP_M12_Human0.81484258
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81428844
81CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77879441
82DNAJC2_21179169_ChIP-ChIP_NT2_Human0.75837584
83NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75667625
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75419312
85MTF2_20144788_ChIP-Seq_MESCs_Mouse0.74108791
86EZH2_27304074_Chip-Seq_ESCs_Mouse0.73908460
87FOXO3_23340844_ChIP-Seq_DLD1_Human0.73832858
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.71371571
89RUNX_20019798_ChIP-Seq_JUKART_Human0.71264630
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.71001965
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69982215
92SOX9_24532713_ChIP-Seq_HFSC_Mouse0.69965706
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.69007333
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.68919013
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68212613
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.65961721
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.65932320
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.65448418
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.64747781
100* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.64550764
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.63701280
102RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63401779
103P300_27058665_Chip-Seq_ZR-75-30cells_Human0.63095249
104KDM2B_26808549_Chip-Seq_SUP-B15_Human0.62903535
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62720993
106KLF4_19829295_ChIP-Seq_ESCs_Human0.62644181
107GATA1_19941826_ChIP-Seq_K562_Human0.60704786
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60185103
109IKZF1_21737484_ChIP-ChIP_HCT116_Human0.60140918
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.59874211
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.59636174
112HOXB7_26014856_ChIP-Seq_BT474_Human0.58939007
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.58701566
114HNF4A_19822575_ChIP-Seq_HepG2_Human0.57499914
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.57424728
116VDR_24787735_ChIP-Seq_THP-1_Human0.56912554
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.55700743
118GATA2_19941826_ChIP-Seq_K562_Human0.55274574
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.55195777
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.54900454
121SOX2_18555785_ChIP-Seq_MESCs_Mouse0.54424726
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.54220167
123ISL1_27105846_Chip-Seq_CPCs_Mouse0.53777863
124ATF3_27146783_Chip-Seq_COLON_Human0.53639361
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.53479564
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.53479564
127TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.53261383
128* TET1_21490601_ChIP-Seq_MESCs_Mouse0.52865383
129SOX2_21211035_ChIP-Seq_LN229_Human0.51814471
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.50899489
131GATA4_21415370_ChIP-Seq_HL-1_Mouse0.50613992
132RACK7_27058665_Chip-Seq_MCF-7_Human0.50206520
133CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.50103411
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.49904346
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.49159756
136GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.48410588
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.47755767
138RUNX1_27514584_Chip-Seq_MCF-7_Human0.47092357
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.46481909
140ER_23166858_ChIP-Seq_MCF-7_Human0.46345298
141GATA3_24758297_ChIP-Seq_MCF-7_Human0.46316221
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.46193386
143AUTS2_25519132_ChIP-Seq_293T-REX_Human0.45785887
144SMC1_22415368_ChIP-Seq_MEFs_Mouse0.45009279
145* ERG_20517297_ChIP-Seq_VCAP_Human0.44701330
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.43884915
147IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.43330795
148SOX2_27498859_Chip-Seq_STOMACH_Mouse0.42606975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose8.85600525
2MP0005666_abnormal_adipose_tissue6.31588498
3MP0004130_abnormal_muscle_cell5.32983256
4MP0004185_abnormal_adipocyte_glucose4.97434218
5* MP0002971_abnormal_brown_adipose4.62259501
6MP0005375_adipose_tissue_phenotype4.12879882
7MP0003646_muscle_fatigue3.81578564
8* MP0005535_abnormal_body_temperature3.10020603
9MP0009840_abnormal_foam_cell2.96838149
10MP0003011_delayed_dark_adaptation2.91165350
11MP0000003_abnormal_adipose_tissue2.75514213
12MP0000013_abnormal_adipose_tissue2.74649578
13MP0002837_dystrophic_cardiac_calcinosis2.70286527
14MP0009115_abnormal_fat_cell2.59882330
15* MP0006036_abnormal_mitochondrial_physio2.59550613
16MP0005334_abnormal_fat_pad2.45669584
17* MP0002970_abnormal_white_adipose2.38475684
18MP0010329_abnormal_lipoprotein_level2.35983875
19* MP0002118_abnormal_lipid_homeostasis2.34590238
20MP0008438_abnormal_cutaneous_collagen2.11636552
21MP0005330_cardiomyopathy2.02066494
22MP0005332_abnormal_amino_acid1.98634018
23MP0002078_abnormal_glucose_homeostasis1.93208169
24MP0003868_abnormal_feces_composition1.84699286
25MP0005584_abnormal_enzyme/coenzyme_acti1.83435803
26MP0009672_abnormal_birth_weight1.71728480
27MP0008961_abnormal_basal_metabolism1.71523668
28MP0000609_abnormal_liver_physiology1.62518654
29MP0002332_abnormal_exercise_endurance1.60992514
30MP0003828_pulmonary_edema1.55739045
31MP0003724_increased_susceptibility_to1.54425567
32MP0001661_extended_life_span1.53493615
33MP0005365_abnormal_bile_salt1.53486705
34* MP0005452_abnormal_adipose_tissue1.48623734
35MP0008775_abnormal_heart_ventricle1.42370953
36MP0003283_abnormal_digestive_organ1.37675800
37MP0003221_abnormal_cardiomyocyte_apopto1.36422447
38* MP0005448_abnormal_energy_balance1.33959282
39MP0003959_abnormal_lean_body1.33604846
40MP0006138_congestive_heart_failure1.31942048
41MP0006035_abnormal_mitochondrial_morpho1.30203023
42MP0005275_abnormal_skin_tensile1.27912231
43MP0004087_abnormal_muscle_fiber1.27801013
44MP0003191_abnormal_cellular_cholesterol1.22953158
45MP0004145_abnormal_muscle_electrophysio1.22088047
46MP0004782_abnormal_surfactant_physiolog1.16379867
47MP0005385_cardiovascular_system_phenoty1.14481752
48MP0001544_abnormal_cardiovascular_syste1.14481752
49MP0003690_abnormal_glial_cell1.11961262
50MP0001177_atelectasis1.10701602
51MP0005645_abnormal_hypothalamus_physiol1.09840742
52MP0005647_abnormal_sex_gland1.06398061
53MP0005319_abnormal_enzyme/_coenzyme1.00116958
54MP0010630_abnormal_cardiac_muscle0.99977801
55MP0004043_abnormal_pH_regulation0.98057633
56MP0001879_abnormal_lymphatic_vessel0.97901222
57MP0004272_abnormal_basement_membrane0.95854527
58MP0009703_decreased_birth_body0.93469188
59MP0000759_abnormal_skeletal_muscle0.92517174
60MP0001853_heart_inflammation0.89627760
61MP0005620_abnormal_muscle_contractility0.86293945
62MP0000343_altered_response_to0.85730503
63* MP0003953_abnormal_hormone_level0.85016452
64MP0003705_abnormal_hypodermis_morpholog0.84840489
65MP0001529_abnormal_vocalization0.83908840
66MP0002972_abnormal_cardiac_muscle0.83438028
67MP0004233_abnormal_muscle_weight0.82131277
68MP0003137_abnormal_impulse_conducting0.81571333
69MP0003329_amyloid_beta_deposits0.76725267
70MP0002796_impaired_skin_barrier0.76573250
71MP0003195_calcinosis0.75964895
72* MP0003948_abnormal_gas_homeostasis0.75264154
73MP0003186_abnormal_redox_activity0.73156051
74MP0004215_abnormal_myocardial_fiber0.72043319
75MP0009643_abnormal_urine_homeostasis0.71932263
76MP0002139_abnormal_hepatobiliary_system0.69612841
77MP0003566_abnormal_cell_adhesion0.69350544
78MP0004742_abnormal_vestibular_system0.69333951
79MP0003950_abnormal_plasma_membrane0.68118032
80MP0005085_abnormal_gallbladder_physiolo0.67796738
81MP0001727_abnormal_embryo_implantation0.66855092
82MP0000604_amyloidosis0.66770042
83MP0005164_abnormal_response_to0.66543429
84MP0000749_muscle_degeneration0.66317104
85MP0001881_abnormal_mammary_gland0.66244364
86MP0003045_fibrosis0.65984441
87MP0005646_abnormal_pituitary_gland0.65815851
88MP0000230_abnormal_systemic_arterial0.64311166
89MP0004484_altered_response_of0.64094611
90MP0003300_gastrointestinal_ulcer0.63365831
91MP0001440_abnormal_grooming_behavior0.63313149
92MP0005083_abnormal_biliary_tract0.62626417
93MP0002133_abnormal_respiratory_system0.62372888
94MP0005388_respiratory_system_phenotype0.62372888
95MP0000751_myopathy0.61908691
96MP0002106_abnormal_muscle_physiology0.58396898
97MP0005386_behavior/neurological_phenoty0.58251097
98MP0004924_abnormal_behavior0.58251097
99MP0009780_abnormal_chondrocyte_physiolo0.57781067
100MP0001764_abnormal_homeostasis0.56873244
101MP0005266_abnormal_metabolism0.56248131
102MP0001756_abnormal_urination0.55875930
103MP0004036_abnormal_muscle_relaxation0.55108320
104MP0000750_abnormal_muscle_regeneration0.50502858
105MP0002638_abnormal_pupillary_reflex0.50427311
106MP0002102_abnormal_ear_morphology0.50267294
107MP0005376_homeostasis/metabolism_phenot0.48648638
108MP0002909_abnormal_adrenal_gland0.48479935
109MP0005076_abnormal_cell_differentiation0.48345013
110MP0000767_abnormal_smooth_muscle0.48146572
111MP0002069_abnormal_eating/drinking_beha0.48129722
112MP0002060_abnormal_skin_morphology0.46718919
113* MP0009642_abnormal_blood_homeostasis0.46484286
114MP0002269_muscular_atrophy0.46364633
115MP0000372_irregular_coat_pigmentation0.45796044
116MP0005595_abnormal_vascular_smooth0.45111944
117MP0000598_abnormal_liver_morphology0.45033344
118MP0001984_abnormal_olfaction0.44490396
119MP0002166_altered_tumor_susceptibility0.43788966
120MP0003942_abnormal_urinary_system0.42213075
121MP0004085_abnormal_heartbeat0.41645397
122MP0000747_muscle_weakness0.41307152
123MP0010030_abnormal_orbit_morphology0.41126458
124MP0001944_abnormal_pancreas_morphology0.40529323
125MP0002876_abnormal_thyroid_physiology0.40501952
126MP0003879_abnormal_hair_cell0.40384458
127MP0002168_other_aberrant_phenotype0.40359355
128MP0000534_abnormal_ureter_morphology0.40064848
129MP0009763_increased_sensitivity_to0.39693314
130MP0005369_muscle_phenotype0.39421710
131MP0004084_abnormal_cardiac_muscle0.39131566
132MP0003279_aneurysm0.38399587
133MP0002877_abnormal_melanocyte_morpholog0.37986365
134MP0006276_abnormal_autonomic_nervous0.37958636

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)7.45699947
2Myoglobinuria (HP:0002913)6.90245486
3Hypoglycemic coma (HP:0001325)6.75440801
4Abnormality of fatty-acid metabolism (HP:0004359)6.57264476
5Abnormality of dicarboxylic acid metabolism (HP:0010995)6.32583942
6Dicarboxylic aciduria (HP:0003215)6.32583942
7Rhabdomyolysis (HP:0003201)6.27773971
8Abnormality of glycine metabolism (HP:0010895)5.84971616
9Abnormality of serine family amino acid metabolism (HP:0010894)5.84971616
10Hepatic necrosis (HP:0002605)5.50254483
11Increased muscle lipid content (HP:0009058)5.31869783
12Hydroxyprolinuria (HP:0003080)4.82135211
13Abnormality of proline metabolism (HP:0010907)4.82135211
14Generalized aminoaciduria (HP:0002909)4.81909337
15Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.66421335
16Hyperammonemia (HP:0001987)4.48808590
17Oligomenorrhea (HP:0000876)4.44489135
18Hyperlipoproteinemia (HP:0010980)4.25866091
19Renal cortical cysts (HP:0000803)4.22449202
20Ketoacidosis (HP:0001993)4.20424401
21Xanthomatosis (HP:0000991)4.17739351
22Epidermoid cyst (HP:0200040)3.97034095
23Potter facies (HP:0002009)3.90012607
24Facial shape deformation (HP:0011334)3.90012607
25Ketosis (HP:0001946)3.86455677
26Hepatocellular necrosis (HP:0001404)3.78011787
27Hyperglycinemia (HP:0002154)3.77667165
28Methylmalonic aciduria (HP:0012120)3.73839089
29Nausea (HP:0002018)3.71334830
30Abnormality of alanine metabolism (HP:0010916)3.71013488
31Hyperalaninemia (HP:0003348)3.71013488
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.71013488
33Skin nodule (HP:0200036)3.68521997
34Infantile muscular hypotonia (HP:0008947)3.65774160
35Tubulointerstitial fibrosis (HP:0005576)3.64199365
36Abnormality of glycolysis (HP:0004366)3.63519061
37Increased serum pyruvate (HP:0003542)3.63519061
38Hypercholesterolemia (HP:0003124)3.60329840
39Acute encephalopathy (HP:0006846)3.59409839
40Limb hypertonia (HP:0002509)3.53781988
41Impulsivity (HP:0100710)3.48518334
42Acanthosis nigricans (HP:0000956)3.46932812
43Hypertriglyceridemia (HP:0002155)3.45940573
44Increased variability in muscle fiber diameter (HP:0003557)3.43758757
45Abnormal mitochondria in muscle tissue (HP:0008316)3.41298345
46Cerebral edema (HP:0002181)3.38994836
47Lactic acidosis (HP:0003128)3.38977815
48Myocardial infarction (HP:0001658)3.36171215
49Proximal tubulopathy (HP:0000114)3.30754599
50Exercise-induced myalgia (HP:0003738)3.16623599
51Lethargy (HP:0001254)3.16348826
52Insulin-resistant diabetes mellitus (HP:0000831)3.12558492
53Cerebral inclusion bodies (HP:0100314)3.11278552
54Increased intramyocellular lipid droplets (HP:0012240)3.10778186
55Acute necrotizing encephalopathy (HP:0006965)3.08810397
56Conjunctival hamartoma (HP:0100780)3.08639822
57Pheochromocytoma (HP:0002666)3.04941946
58Difficulty running (HP:0009046)3.04928868
59Bone cyst (HP:0012062)3.04199002
60Methylmalonic acidemia (HP:0002912)2.94656835
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.93285840
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.93285840
63Long foot (HP:0001833)2.92432367
64Muscle stiffness (HP:0003552)2.90899451
65Increased CSF lactate (HP:0002490)2.89191379
66Back pain (HP:0003418)2.88959875
67Lipid accumulation in hepatocytes (HP:0006561)2.83436692
68Premature rupture of membranes (HP:0001788)2.79866508
69Respiratory failure (HP:0002878)2.76386738
70Athetosis (HP:0002305)2.75688214
71Abnormality of serum amino acid levels (HP:0003112)2.72896402
72Abnormal hemoglobin (HP:0011902)2.71497205
73Progressive macrocephaly (HP:0004481)2.70780393
74Neonatal death (HP:0003811)2.65709534
75Hemorrhage of the eye (HP:0011885)2.64277797
76Neuroendocrine neoplasm (HP:0100634)2.64184127
77Neoplasm of head and neck (HP:0012288)2.61062826
78Esophageal neoplasm (HP:0100751)2.61062826
79Vomiting (HP:0002013)2.59594209
80Abnormality of skeletal muscle fiber size (HP:0012084)2.59096528
81Buphthalmos (HP:0000557)2.58265253
82Mitochondrial inheritance (HP:0001427)2.56389386
83Tachypnea (HP:0002789)2.56140811
84Facial diplegia (HP:0001349)2.55161818
85Abnormality of glutamine family amino acid metabolism (HP:0010902)2.53237225
86Metabolic acidosis (HP:0001942)2.52205610
87Mesangial abnormality (HP:0001966)2.49505032
88Cerebral hemorrhage (HP:0001342)2.46366843
89Polyphagia (HP:0002591)2.45462276
90Tubulointerstitial abnormality (HP:0001969)2.44867553
91Neurofibrillary tangles (HP:0002185)2.44039516
92Subcapsular cataract (HP:0000523)2.39629175
93Hamartoma of the eye (HP:0010568)2.36657121
94Protrusio acetabuli (HP:0003179)2.28693442
95Reduced antithrombin III activity (HP:0001976)2.22853197
96Large hands (HP:0001176)2.21368565
97Megalocornea (HP:0000485)2.20776457
98Upper motor neuron abnormality (HP:0002127)2.18857168
99Ectopia lentis (HP:0001083)2.16536162
100Coronal craniosynostosis (HP:0004440)2.16347031
101Growth hormone excess (HP:0000845)2.15292179
102Renal Fanconi syndrome (HP:0001994)2.14536742
103Exertional dyspnea (HP:0002875)2.13867025
104Type II lissencephaly (HP:0007260)2.13568052
105Opisthotonus (HP:0002179)2.13534440
106Neonatal onset (HP:0003623)2.13510573
107Abnormality of abdominal situs (HP:0011620)2.09139132
108Abdominal situs inversus (HP:0003363)2.09139132
109Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.08894835
110Pachygyria (HP:0001302)2.07917909
111Hypoglycemic seizures (HP:0002173)2.07539902
112Vertebral compression fractures (HP:0002953)2.05999959
113Pigmentary retinal degeneration (HP:0001146)2.05186108
114Vertebral hypoplasia (HP:0008417)2.04084473
115Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.04084473
116Abnormal social behavior (HP:0012433)2.03547919
117Impaired social interactions (HP:0000735)2.03547919
118Prominent supraorbital ridges (HP:0000336)2.03376466
119Exercise intolerance (HP:0003546)2.03110525
120Prenatal maternal abnormality (HP:0002686)2.02853152
121Axonal loss (HP:0003447)2.01239468
122Stridor (HP:0010307)2.00308991
123Insulin resistance (HP:0000855)2.00128323
124Increased connective tissue (HP:0009025)1.99656986
125Pancreatitis (HP:0001733)1.98616620
126Hepatosplenomegaly (HP:0001433)1.98491084
127Increased serum lactate (HP:0002151)1.98166999
128Multiple enchondromatosis (HP:0005701)1.97588410
129Abnormality of the renal cortex (HP:0011035)1.96976008
130Hypoalphalipoproteinemia (HP:0003233)1.96162493
131Respiratory distress (HP:0002098)1.95113595
132Abnormality of purine metabolism (HP:0004352)1.94874754
133Neonatal hypoglycemia (HP:0001998)1.94723747
134Neoplasm of the adrenal gland (HP:0100631)1.94637780
135Tetraparesis (HP:0002273)1.94456620
136Abnormal glucose tolerance (HP:0001952)1.91432091
137Dilated cardiomyopathy (HP:0001644)1.90802673
138Delayed CNS myelination (HP:0002188)1.90446495
139Elevated hepatic transaminases (HP:0002910)1.87967205
140Frequent falls (HP:0002359)1.86439269
141Sudden death (HP:0001699)1.84311044
142Dysmetric saccades (HP:0000641)1.84057285
143Reduced subcutaneous adipose tissue (HP:0003758)1.83098470
144Gliosis (HP:0002171)1.82757967
145Renal tubular dysfunction (HP:0000124)1.81939902
146Ankle contracture (HP:0006466)1.79392449
147Ileus (HP:0002595)1.79205012
148Abnormal cartilage morphology (HP:0002763)1.79064706
149Lipoatrophy (HP:0100578)1.78983739
150Abnormality of the periventricular white matter (HP:0002518)1.78522132
151Acute hepatic failure (HP:0006554)1.77894032
152Renal tubular acidosis (HP:0001947)1.76054919
153Palpitations (HP:0001962)1.76050485
154Wide anterior fontanel (HP:0000260)1.75276885
155Glycosuria (HP:0003076)1.75133009
156Abnormality of urine glucose concentration (HP:0011016)1.75133009
157Hyperinsulinemic hypoglycemia (HP:0000825)1.71932184
158Abnormality of the basal ganglia (HP:0002134)1.67636956
159Ragged-red muscle fibers (HP:0003200)1.67289398
160CNS demyelination (HP:0007305)1.66740770
161Hyperglycemia (HP:0003074)1.64481977
162Delayed gross motor development (HP:0002194)1.63966157
163Abnormality of vision evoked potentials (HP:0000649)1.63518863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D6.22438798
2BCKDK6.22023275
3PDK46.11709116
4PDK36.11709116
5TRIB34.89801972
6CAMK1G4.48778853
7PDK23.91307977
8SIK12.75345126
9PRKAA22.10920256
10MAP2K72.09222866
11MAP3K41.92726827
12EPHA31.70396150
13DAPK31.52163108
14PIM21.47578770
15INSRR1.45501043
16CDK91.42957489
17PDPK11.40590781
18MAP2K41.38088466
19MYLK1.31685862
20PRKD31.30853772
21LATS11.21527363
22PDK11.19715916
23TIE11.19634781
24TYRO31.14539390
25PRKAA11.08945970
26RIPK11.07595582
27PKN21.04726343
28PDGFRA1.04145132
29NLK0.98435414
30PINK10.97466519
31CDK30.96167961
32PRKCH0.95984217
33ERN10.94206936
34MAP3K50.93756155
35TGFBR20.91616911
36TESK10.91180287
37CDK60.89323753
38LATS20.87294411
39SGK20.86893685
40MARK10.83830639
41MAP2K10.81639825
42PAK20.81463208
43DYRK30.78522969
44DYRK1B0.77904930
45PRKACG0.72354246
46MAP3K60.71607789
47JAK10.70420924
48FGFR30.68377479
49TTN0.68204054
50MAPK30.68051795
51LMTK20.66620539
52FGFR20.64551676
53EPHB10.63865050
54PTK20.63573149
55MST1R0.60548685
56CDK40.59329920
57NTRK30.58910394
58PRPF4B0.58637542
59DYRK20.56900233
60MTOR0.56453130
61CAMK10.56352179
62TAOK10.54417688
63STK160.52175370
64CLK10.51785170
65STK38L0.51764703
66MAP2K30.51659030
67FRK0.49900803
68FGFR40.48719828
69ICK0.47306569
70ABL20.46485550
71ILK0.46381090
72GSK3A0.45835326
73PRKG10.45697074
74PRKD10.45059376
75ROCK10.43477433
76MAPK110.43456908
77STK30.43396511
78SGK30.42848276
79PIK3CA0.42690834
80NEK90.42154167
81WNK10.41683303
82STK110.41145031
83CAMKK10.38753498
84CDC42BPA0.38555244
85JAK20.38457557
86FLT30.37450364
87PRKD20.37402593
88CASK0.37157632
89TYK20.37100067
90EPHB20.36074717
91PDGFRB0.35761147
92RET0.35527808
93IGF1R0.34301250
94EIF2AK20.34087914
95INSR0.33257564
96PAK60.32966949
97AKT20.32058657
98PRKCE0.31902894
99IRAK30.31888764
100MAPK130.31609428
101MAPK10.31468651
102CAMK40.31416253
103RPS6KA20.30628497
104JAK30.28934730
105MAPK40.28783733
106PAK10.28694866
107PHKG20.28424942
108PHKG10.28424942
109NTRK10.27518666
110RPS6KB10.27001476
111PKN10.26576332
112SGK2230.25669968
113SGK4940.25669968
114KSR20.25528487
115GRK50.24165325
116PTK2B0.22581216
117CDK50.22451802
118MARK20.20399062
119BMX0.20035977
120PRKG20.19180657
121AKT10.18906299
122PRKACA0.18489691
123IRAK20.18097418
124CAMKK20.17622301
125PTK60.17349541
126RPS6KA30.16700612
127IRAK10.16219518
128DDR20.16183395
129MAPK120.15993881
130SGK10.15802523
131MET0.15101342
132STK380.13368445
133SRC0.12695300
134FGFR10.11156730
135NEK10.11022043
136KDR0.10432345
137PRKCZ0.10342287
138MAPK80.10093360
139MAP3K20.09495907
140CSNK1G10.08368147

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.72648553
2Propanoate metabolism_Homo sapiens_hsa006405.74692442
3Fatty acid metabolism_Homo sapiens_hsa012124.66155317
4Fatty acid degradation_Homo sapiens_hsa000714.60589621
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002804.08646716
6Fatty acid biosynthesis_Homo sapiens_hsa000613.90040583
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.48360406
8Fatty acid elongation_Homo sapiens_hsa000622.97700758
9* PPAR signaling pathway_Homo sapiens_hsa033202.95816320
10Pyruvate metabolism_Homo sapiens_hsa006202.81097262
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70458405
12Carbon metabolism_Homo sapiens_hsa012002.66399936
13Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.08257368
14Butanoate metabolism_Homo sapiens_hsa006501.97848009
15Steroid biosynthesis_Homo sapiens_hsa001001.87460296
16Glycerolipid metabolism_Homo sapiens_hsa005611.57601547
17beta-Alanine metabolism_Homo sapiens_hsa004101.55697652
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.45394732
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41147259
20Sulfur relay system_Homo sapiens_hsa041221.39784954
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36302818
22Oxidative phosphorylation_Homo sapiens_hsa001901.31873548
23AMPK signaling pathway_Homo sapiens_hsa041521.28446323
24Peroxisome_Homo sapiens_hsa041461.25957664
25Parkinsons disease_Homo sapiens_hsa050121.25496911
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23300665
27Glucagon signaling pathway_Homo sapiens_hsa049221.20591962
28Tryptophan metabolism_Homo sapiens_hsa003801.13718230
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09425773
30Insulin resistance_Homo sapiens_hsa049311.02484431
31Alzheimers disease_Homo sapiens_hsa050100.98163963
32Insulin signaling pathway_Homo sapiens_hsa049100.94986597
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91822659
34Lysine degradation_Homo sapiens_hsa003100.91349794
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84165903
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79925165
37Biosynthesis of amino acids_Homo sapiens_hsa012300.77631216
38Glycerophospholipid metabolism_Homo sapiens_hsa005640.76208451
39Huntingtons disease_Homo sapiens_hsa050160.74248677
40Fat digestion and absorption_Homo sapiens_hsa049750.72388615
41Nitrogen metabolism_Homo sapiens_hsa009100.71445450
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64186028
43One carbon pool by folate_Homo sapiens_hsa006700.63803669
44Histidine metabolism_Homo sapiens_hsa003400.62713934
45Pentose phosphate pathway_Homo sapiens_hsa000300.60827159
46Renin-angiotensin system_Homo sapiens_hsa046140.60804644
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57728377
48Cardiac muscle contraction_Homo sapiens_hsa042600.49736093
49Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49241654
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.47591543
51Starch and sucrose metabolism_Homo sapiens_hsa005000.46620369
52Sulfur metabolism_Homo sapiens_hsa009200.44946569
53Renin secretion_Homo sapiens_hsa049240.42844459
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37963608
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36231607
56Metabolic pathways_Homo sapiens_hsa011000.35837711
57Caffeine metabolism_Homo sapiens_hsa002320.34350449
58Vitamin B6 metabolism_Homo sapiens_hsa007500.32639054
59Retinol metabolism_Homo sapiens_hsa008300.30576602
60HIF-1 signaling pathway_Homo sapiens_hsa040660.25448692
61Folate biosynthesis_Homo sapiens_hsa007900.25085090
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.24438013
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23730035
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23659921
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.22474742
66Arginine and proline metabolism_Homo sapiens_hsa003300.22360786
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21981604
68Salivary secretion_Homo sapiens_hsa049700.19885948
69Fructose and mannose metabolism_Homo sapiens_hsa000510.18598770
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18089061
71ABC transporters_Homo sapiens_hsa020100.17557767
72Type II diabetes mellitus_Homo sapiens_hsa049300.17084032
73Galactose metabolism_Homo sapiens_hsa000520.13780794
74ECM-receptor interaction_Homo sapiens_hsa045120.12307686
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.11753144
76mTOR signaling pathway_Homo sapiens_hsa041500.09445069
77Cocaine addiction_Homo sapiens_hsa050300.09168854
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.08390498
79Tyrosine metabolism_Homo sapiens_hsa003500.07903694
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06920399
81Phenylalanine metabolism_Homo sapiens_hsa003600.06790136
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.06368810
83Ovarian steroidogenesis_Homo sapiens_hsa049130.06000409
84Basal cell carcinoma_Homo sapiens_hsa052170.05855422
85Thyroid cancer_Homo sapiens_hsa052160.05084944
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.04362635
87Bile secretion_Homo sapiens_hsa049760.03201052
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.03148653
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.03060481
90Acute myeloid leukemia_Homo sapiens_hsa052210.01982525
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.01541691
92Sphingolipid metabolism_Homo sapiens_hsa00600-0.1387170
93Melanogenesis_Homo sapiens_hsa04916-0.1333575
94Hepatitis C_Homo sapiens_hsa05160-0.1311861
95Proteoglycans in cancer_Homo sapiens_hsa05205-0.1252744
96Dopaminergic synapse_Homo sapiens_hsa04728-0.1075301
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532-0.1015467
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0955975
99Calcium signaling pathway_Homo sapiens_hsa04020-0.0954251
100Estrogen signaling pathway_Homo sapiens_hsa04915-0.0952675
101PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0901724
102Gap junction_Homo sapiens_hsa04540-0.0899483
103Arginine biosynthesis_Homo sapiens_hsa00220-0.0893995
104Cyanoamino acid metabolism_Homo sapiens_hsa00460-0.0834711
105Choline metabolism in cancer_Homo sapiens_hsa05231-0.0824446
106Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0822364
107Thyroid hormone signaling pathway_Homo sapiens_hsa04919-0.0770156
108Viral myocarditis_Homo sapiens_hsa05416-0.0761800
109Renal cell carcinoma_Homo sapiens_hsa05211-0.0749160
110Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0734740
111Morphine addiction_Homo sapiens_hsa05032-0.0715928
112Small cell lung cancer_Homo sapiens_hsa05222-0.0711758
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.0708388
114Glutathione metabolism_Homo sapiens_hsa00480-0.0703375
115Gastric acid secretion_Homo sapiens_hsa04971-0.0656964
116Linoleic acid metabolism_Homo sapiens_hsa00591-0.0590399
117FoxO signaling pathway_Homo sapiens_hsa04068-0.0587468
118Amoebiasis_Homo sapiens_hsa05146-0.0555149
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0434175
120Chemical carcinogenesis_Homo sapiens_hsa05204-0.0407804
121Platelet activation_Homo sapiens_hsa04611-0.0367768
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0362442
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0252765
124Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0221618
125Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0182454
126Protein digestion and absorption_Homo sapiens_hsa04974-0.0181115
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0148217
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0144759
129Focal adhesion_Homo sapiens_hsa04510-0.0092927
130cAMP signaling pathway_Homo sapiens_hsa04024-0.0074609
131Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0012611
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0002109

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