UCP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.05005790
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.05005790
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03622642
4positive regulation of gamma-delta T cell activation (GO:0046645)5.02439104
5antigen processing and presentation of endogenous antigen (GO:0019883)4.82854957
6positive regulation of B cell differentiation (GO:0045579)4.42434740
7B cell receptor signaling pathway (GO:0050853)4.20878563
8immunoglobulin mediated immune response (GO:0016064)4.13993758
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.08603148
10positive T cell selection (GO:0043368)4.01190951
11regulation of B cell receptor signaling pathway (GO:0050855)3.98613470
12Arp2/3 complex-mediated actin nucleation (GO:0034314)3.92445815
13negative regulation of phagocytosis (GO:0050765)3.91542647
14regulation of gamma-delta T cell differentiation (GO:0045586)3.89518869
15regulation of B cell differentiation (GO:0045577)3.86788885
16leukocyte aggregation (GO:0070486)3.76188972
17positive regulation by symbiont of host defense response (GO:0052509)3.75387463
18modulation by symbiont of host defense response (GO:0052031)3.75387463
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.75387463
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.75387463
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.75387463
22modulation by symbiont of host immune response (GO:0052553)3.75387463
23T cell selection (GO:0045058)3.75349799
24cellular extravasation (GO:0045123)3.68470704
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.63529436
26regulation of gamma-delta T cell activation (GO:0046643)3.62350011
27natural killer cell differentiation (GO:0001779)3.59414106
28neutrophil activation involved in immune response (GO:0002283)3.55720984
29regulation of natural killer cell mediated immunity (GO:0002715)3.54113868
30regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.54113868
31NIK/NF-kappaB signaling (GO:0038061)3.44762967
32tolerance induction (GO:0002507)3.43708702
33respiratory burst (GO:0045730)3.38830186
34detection of bacterium (GO:0016045)3.36196273
35regulation of interferon-beta biosynthetic process (GO:0045357)3.34934962
36antigen processing and presentation via MHC class Ib (GO:0002475)3.33696756
37B cell mediated immunity (GO:0019724)3.33192342
38cytidine metabolic process (GO:0046087)3.31967407
39cytidine catabolic process (GO:0006216)3.31967407
40cytidine deamination (GO:0009972)3.31967407
41regulation of alpha-beta T cell proliferation (GO:0046640)3.28217019
42cellular response to interleukin-15 (GO:0071350)3.27253285
43positive thymic T cell selection (GO:0045059)3.27087504
44regulation of tolerance induction (GO:0002643)3.25818004
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.24842786
46negative regulation of cell killing (GO:0031342)3.24842786
47regulation of T cell tolerance induction (GO:0002664)3.24725587
48regulation of regulatory T cell differentiation (GO:0045589)3.22355372
49regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.21263966
50detection of other organism (GO:0098543)3.19953262
51positive regulation of tolerance induction (GO:0002645)3.17871923
52DNA deamination (GO:0045006)3.15487035
53hepatocyte apoptotic process (GO:0097284)3.13565205
54positive regulation of natural killer cell mediated immunity (GO:0002717)3.12276622
55mast cell activation (GO:0045576)3.12208012
56T cell migration (GO:0072678)3.10250468
57leukocyte degranulation (GO:0043299)3.07328311
58positive regulation of lamellipodium assembly (GO:0010592)3.07081277
59negative regulation of lymphocyte mediated immunity (GO:0002707)3.06438926
60activated T cell proliferation (GO:0050798)3.05987061
61negative regulation of granulocyte differentiation (GO:0030853)3.04563256
62cellular response to zinc ion (GO:0071294)3.03615047
63negative regulation of leukocyte mediated immunity (GO:0002704)3.03425294
64positive regulation of interferon-alpha production (GO:0032727)3.02665755
65regulation of mast cell degranulation (GO:0043304)3.00887979
66positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.99822437
67positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99622349
68regulation of leukocyte mediated cytotoxicity (GO:0001910)2.98839013
69pyrimidine ribonucleoside catabolic process (GO:0046133)2.97528790
70regulation of T cell mediated cytotoxicity (GO:0001914)2.96899884
71negative regulation of T cell apoptotic process (GO:0070233)2.96229157
72T cell receptor signaling pathway (GO:0050852)2.95757896
73regulation of antigen processing and presentation (GO:0002577)2.95750304
74myeloid dendritic cell activation (GO:0001773)2.95699325
75regulation of interferon-alpha production (GO:0032647)2.94177825
76ribosomal small subunit assembly (GO:0000028)2.94112804
77neutrophil activation (GO:0042119)2.94028077
78positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93637540
79actin nucleation (GO:0045010)2.90948146
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90665033
81regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89261025
82T cell homeostasis (GO:0043029)2.88133362
83Peyers patch development (GO:0048541)2.87705440
84mucosal-associated lymphoid tissue development (GO:0048537)2.87705440
85regulation of interleukin-2 biosynthetic process (GO:0045076)2.87618043
86T cell costimulation (GO:0031295)2.87567368
87regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.85626970
88lymphocyte costimulation (GO:0031294)2.84436849
89regulation of interleukin-12 biosynthetic process (GO:0045075)2.83168490
90lymphocyte homeostasis (GO:0002260)2.81596989
91positive regulation of histone deacetylation (GO:0031065)2.79931600
92response to type I interferon (GO:0034340)2.79091827
93positive regulation of cell killing (GO:0031343)2.78463667
94regulation of germinal center formation (GO:0002634)2.78292724
95autophagic vacuole fusion (GO:0000046)2.78146168
96positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77953970
97regulation of cell killing (GO:0031341)2.77824836
98positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.77398919
99defense response to protozoan (GO:0042832)2.76891273
100granulocyte activation (GO:0036230)2.75761387
101antigen receptor-mediated signaling pathway (GO:0050851)2.74592697
102response to interferon-beta (GO:0035456)2.73680765
103myeloid dendritic cell differentiation (GO:0043011)2.73384610
104cellular response to type I interferon (GO:0071357)2.72068824
105type I interferon signaling pathway (GO:0060337)2.72068824
106myeloid cell activation involved in immune response (GO:0002275)2.71022321
107positive regulation of granulocyte differentiation (GO:0030854)2.70428993
108JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.70298153
109response to protozoan (GO:0001562)2.70223811
110macrophage activation involved in immune response (GO:0002281)2.69677977
111positive regulation of macrophage differentiation (GO:0045651)2.68090803
112interferon-gamma-mediated signaling pathway (GO:0060333)2.67349913
113regulation of granulocyte differentiation (GO:0030852)2.67020432
114negative thymic T cell selection (GO:0045060)2.66743935
115positive regulation of lamellipodium organization (GO:1902745)2.65349509
116natural killer cell activation (GO:0030101)2.65112879
117negative regulation of bone resorption (GO:0045779)2.64409208
118leukocyte cell-cell adhesion (GO:0007159)2.62158988
119response to peptidoglycan (GO:0032494)2.58840501
120regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57400752
121negative T cell selection (GO:0043383)2.57335584
122mast cell activation involved in immune response (GO:0002279)2.57084034
123mast cell degranulation (GO:0043303)2.57084034
124viral transcription (GO:0019083)2.56761692
125negative regulation of B cell proliferation (GO:0030889)2.55048839
126positive regulation of protein deacetylation (GO:0090312)2.54832657
127thymic T cell selection (GO:0045061)2.54620825
128positive regulation of isotype switching (GO:0045830)2.52883829
129regulation of T cell receptor signaling pathway (GO:0050856)2.49301153
130leukocyte homeostasis (GO:0001776)2.49047702
131positive regulation of antigen processing and presentation (GO:0002579)2.48301601
132regulation of erythrocyte differentiation (GO:0045646)2.47598167
133response to interleukin-15 (GO:0070672)2.46448482
134pinocytosis (GO:0006907)2.44901777
135positive regulation of B cell activation (GO:0050871)2.44386987
136regulation of superoxide anion generation (GO:0032928)2.41090540
137telomere maintenance via semi-conservative replication (GO:0032201)2.40608111
138negative regulation of interleukin-12 production (GO:0032695)2.39933516
139translational termination (GO:0006415)2.39419836
140V(D)J recombination (GO:0033151)2.39378699
141pentose-phosphate shunt (GO:0006098)2.38367112
142negative regulation of erythrocyte differentiation (GO:0045647)2.37662456
143DNA unwinding involved in DNA replication (GO:0006268)2.37183649
144positive regulation of mast cell activation (GO:0033005)2.37145108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.58633292
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.08810123
3* MYC_22102868_ChIP-Seq_BL_Human3.33077413
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.09312466
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.08624755
6* IRF8_21731497_ChIP-ChIP_J774_Mouse3.08298370
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.03647105
8VDR_21846776_ChIP-Seq_THP-1_Human2.95252553
9* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91403125
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.75493377
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.74458998
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71363213
13SCL_19346495_ChIP-Seq_HPC-7_Human2.66339273
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54240601
15* FOXM1_23109430_ChIP-Seq_U2OS_Human2.49156050
16* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39527302
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36791425
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33553235
19* IRF8_27001747_Chip-Seq_BMDM_Mouse2.31372616
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27343247
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25281983
22* MYB_26560356_Chip-Seq_TH2_Human2.24138686
23* MAF_26560356_Chip-Seq_TH1_Human2.19837383
24VDR_24763502_ChIP-Seq_THP-1_Human2.18353615
25* SPI1_23547873_ChIP-Seq_NB4_Human2.08596333
26* UTX_26944678_Chip-Seq_JUKART_Human2.06392193
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06090212
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05962946
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.93767560
30* MYB_26560356_Chip-Seq_TH1_Human1.92791533
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90732151
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.90235090
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88581111
34* TCF7_22412390_ChIP-Seq_EML_Mouse1.88376075
35RUNX_20019798_ChIP-Seq_JUKART_Human1.85969690
36* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85816087
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85296858
38* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84847030
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83286570
40* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83258031
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82120679
42GATA1_22025678_ChIP-Seq_K562_Human1.72792903
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71839636
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67834348
45SPI1_23127762_ChIP-Seq_K562_Human1.63583055
46* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58197192
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56836863
48GATA1_22383799_ChIP-Seq_G1ME_Mouse1.51979113
49* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50608103
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48998532
51CIITA_25753668_ChIP-Seq_RAJI_Human1.47328638
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45736155
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44849844
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.42816985
55* MAF_26560356_Chip-Seq_TH2_Human1.42096576
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.40703189
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38950848
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37718305
59BCOR_27268052_Chip-Seq_Bcells_Human1.37100641
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35384218
61* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34349706
62* KDM2B_26808549_Chip-Seq_DND41_Human1.34266431
63* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34255284
64* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31446372
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28500649
66GATA3_27048872_Chip-Seq_THYMUS_Human1.27549956
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.23779897
68* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23589535
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22212042
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21346555
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19550454
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16943300
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15803312
74PU_27001747_Chip-Seq_BMDM_Mouse1.15779730
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15738443
76P300_27268052_Chip-Seq_Bcells_Human1.15117635
77SPI1_20517297_ChIP-Seq_HL60_Human1.14922120
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13148966
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12485997
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11589491
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.06180495
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05980427
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05836007
84JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05518203
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05098339
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05085097
87P68_20966046_ChIP-Seq_HELA_Human1.03837975
88VDR_23849224_ChIP-Seq_CD4+_Human1.02884416
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.02639493
90TFEB_21752829_ChIP-Seq_HELA_Human1.01956819
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01548356
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01299606
93CTCF_26484167_Chip-Seq_Bcells_Mouse1.01056599
94GATA1_19941826_ChIP-Seq_K562_Human0.99876723
95FOXP3_21729870_ChIP-Seq_TREG_Human0.99363259
96NCOR1_26117541_ChIP-Seq_K562_Human0.99290151
97GATA2_19941826_ChIP-Seq_K562_Human0.99156986
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98118869
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97503974
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97442194
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95330035
102MYC_18555785_ChIP-Seq_MESCs_Mouse0.95198232
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95143352
104* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94931714
105LXR_22292898_ChIP-Seq_THP-1_Human0.94739497
106E2F1_20622854_ChIP-Seq_HELA_Human0.94551232
107VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94449894
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93184915
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91222268
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.89824135
111XRN2_22483619_ChIP-Seq_HELA_Human0.87609508
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85791155
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85525220
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84196014
115GATA3_26560356_Chip-Seq_TH2_Human0.82372877
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82365097
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80903748
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79281666
119KDM5A_27292631_Chip-Seq_BREAST_Human0.79145665
120MYC_18358816_ChIP-ChIP_MESCs_Mouse0.76794658
121NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.76331802
122BCL6_27268052_Chip-Seq_Bcells_Human0.76010610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.78649394
2MP0000685_abnormal_immune_system3.29549409
3MP0003436_decreased_susceptibility_to3.01126188
4MP0001800_abnormal_humoral_immune2.93044427
5MP0005671_abnormal_response_to2.92023230
6MP0003303_peritoneal_inflammation2.86867173
7MP0001790_abnormal_immune_system2.80443087
8MP0005387_immune_system_phenotype2.80443087
9MP0005000_abnormal_immune_tolerance2.64820514
10* MP0002452_abnormal_antigen_presenting2.62678906
11MP0003300_gastrointestinal_ulcer2.60281571
12MP0002396_abnormal_hematopoietic_system2.54401628
13MP0002723_abnormal_immune_serum2.45812588
14* MP0002420_abnormal_adaptive_immunity2.43608930
15* MP0001819_abnormal_immune_cell2.42219167
16MP0002398_abnormal_bone_marrow2.42148687
17* MP0009785_altered_susceptibility_to2.40940060
18* MP0005025_abnormal_response_to2.40105886
19MP0003763_abnormal_thymus_physiology2.36713864
20* MP0002419_abnormal_innate_immunity2.22001733
21MP0002148_abnormal_hypersensitivity_rea2.21042886
22MP0002166_altered_tumor_susceptibility2.16852337
23MP0000716_abnormal_immune_system2.14212035
24MP0009333_abnormal_splenocyte_physiolog2.11453294
25MP0005464_abnormal_platelet_physiology2.09636247
26MP0000689_abnormal_spleen_morphology2.06631728
27MP0002405_respiratory_system_inflammati2.06031767
28MP0002722_abnormal_immune_system2.02721143
29MP0010155_abnormal_intestine_physiology2.00392984
30MP0001545_abnormal_hematopoietic_system2.00300038
31MP0005397_hematopoietic_system_phenotyp2.00300038
32MP0009278_abnormal_bone_marrow1.97722362
33MP0003724_increased_susceptibility_to1.92806643
34MP0004808_abnormal_hematopoietic_stem1.92058504
35MP0002429_abnormal_blood_cell1.87068482
36MP0004947_skin_inflammation1.86599307
37MP0000490_abnormal_crypts_of1.85586965
38MP0001873_stomach_inflammation1.84830714
39MP0006082_CNS_inflammation1.78535459
40MP0003866_abnormal_defecation1.71650148
41MP0000703_abnormal_thymus_morphology1.71015511
42MP0002006_tumorigenesis1.68688653
43MP0001845_abnormal_inflammatory_respons1.67872279
44MP0003806_abnormal_nucleotide_metabolis1.56156677
45MP0003656_abnormal_erythrocyte_physiolo1.52875088
46MP0001853_heart_inflammation1.52649768
47MP0005310_abnormal_salivary_gland1.51111525
48MP0000465_gastrointestinal_hemorrhage1.46327679
49MP0003191_abnormal_cellular_cholesterol1.44944239
50MP0001533_abnormal_skeleton_physiology1.44856375
51MP0006054_spinal_hemorrhage1.44149572
52MP0005058_abnormal_lysosome_morphology1.43864774
53MP0005451_abnormal_body_composition1.43708043
54MP0003693_abnormal_embryo_hatching1.29851519
55MP0010352_gastrointestinal_tract_polyps1.26946697
56MP0010307_abnormal_tumor_latency1.26426133
57MP0008469_abnormal_protein_level1.25849747
58MP0004510_myositis1.25168191
59MP0000858_altered_metastatic_potential1.24665805
60MP0002933_joint_inflammation1.23387927
61MP0005076_abnormal_cell_differentiation1.22652022
62MP0002019_abnormal_tumor_incidence1.22279959
63MP0010094_abnormal_chromosome_stability1.21339215
64MP0005083_abnormal_biliary_tract1.15241622
65MP0004381_abnormal_hair_follicle1.09570981
66MP0003172_abnormal_lysosome_physiology1.08495745
67MP0003448_altered_tumor_morphology1.08392177
68MP0008004_abnormal_stomach_pH1.06780029
69MP0004147_increased_porphyrin_level1.04731182
70MP0005174_abnormal_tail_pigmentation1.04606485
71MP0003077_abnormal_cell_cycle1.02926553
72MP0002138_abnormal_hepatobiliary_system0.99859340
73MP0002277_abnormal_respiratory_mucosa0.99610159
74MP0003111_abnormal_nucleus_morphology0.99107560
75MP0008260_abnormal_autophagy0.98300691
76MP0003183_abnormal_peptide_metabolism0.95078637
77MP0001663_abnormal_digestive_system0.91505880
78MP0009840_abnormal_foam_cell0.91076449
79MP0008057_abnormal_DNA_replication0.89188172
80MP0009764_decreased_sensitivity_to0.88993157
81MP0003566_abnormal_cell_adhesion0.88891892
82MP0000343_altered_response_to0.88615952
83MP0008007_abnormal_cellular_replicative0.87985986
84MP0001851_eye_inflammation0.87704611
85MP0002877_abnormal_melanocyte_morpholog0.85891657
86MP0004957_abnormal_blastocyst_morpholog0.82354480
87* MP0006036_abnormal_mitochondrial_physio0.79144068
88MP0002998_abnormal_bone_remodeling0.78760573
89MP0000372_irregular_coat_pigmentation0.77100857
90MP0003828_pulmonary_edema0.76978159
91MP0003878_abnormal_ear_physiology0.76730435
92MP0005377_hearing/vestibular/ear_phenot0.76730435
93MP0000477_abnormal_intestine_morphology0.76569631
94MP0002132_abnormal_respiratory_system0.75021390
95MP0009765_abnormal_xenobiotic_induced0.74800260
96* MP0000313_abnormal_cell_death0.74506818
97MP0003453_abnormal_keratinocyte_physiol0.69710398
98MP0003045_fibrosis0.69179532
99* MP0005166_decreased_susceptibility_to0.69094071
100MP0009763_increased_sensitivity_to0.68180823
101MP0009931_abnormal_skin_appearance0.67935688
102MP0000015_abnormal_ear_pigmentation0.67034721
103MP0002136_abnormal_kidney_physiology0.66969079
104MP0008872_abnormal_physiological_respon0.66885028
105MP0001986_abnormal_taste_sensitivity0.66216439
106MP0002095_abnormal_skin_pigmentation0.65217286
107MP0005023_abnormal_wound_healing0.64724240
108* MP0003075_altered_response_to0.63950531
109MP0005075_abnormal_melanosome_morpholog0.63811830
110MP0008961_abnormal_basal_metabolism0.63681538
111MP0004883_abnormal_blood_vessel0.62811172
112MP0002653_abnormal_ependyma_morphology0.62251301
113MP0008873_increased_physiological_sensi0.61554110
114MP0000350_abnormal_cell_proliferation0.60839953
115MP0002693_abnormal_pancreas_physiology0.60579708
116MP0000249_abnormal_blood_vessel0.59677090
117MP0008875_abnormal_xenobiotic_pharmacok0.58720697
118MP0005319_abnormal_enzyme/_coenzyme0.58603016
119MP0003795_abnormal_bone_structure0.58579598
120MP0005584_abnormal_enzyme/coenzyme_acti0.57242104
121MP0005390_skeleton_phenotype0.57170837
122MP0009643_abnormal_urine_homeostasis0.56856830
123MP0000598_abnormal_liver_morphology0.55769310
124MP0010234_abnormal_vibrissa_follicle0.55687938
125MP0001216_abnormal_epidermal_layer0.55239138
126MP0000609_abnormal_liver_physiology0.54080831
127MP0003638_abnormal_response/metabolism_0.53630503

Predicted human phenotypes

RankGene SetZ-score
1Cellulitis (HP:0100658)5.26818029
2Agammaglobulinemia (HP:0004432)4.98662657
3Recurrent abscess formation (HP:0002722)4.92564365
4Eczematoid dermatitis (HP:0000976)4.65471990
5Recurrent bacterial skin infections (HP:0005406)4.38509683
6IgM deficiency (HP:0002850)4.22932922
7Recurrent viral infections (HP:0004429)4.19324174
8Recurrent fungal infections (HP:0002841)4.06122361
9Meningitis (HP:0001287)3.97910046
10Papilloma (HP:0012740)3.97308233
11Verrucae (HP:0200043)3.97308233
12Recurrent bronchitis (HP:0002837)3.94204573
13Thyroiditis (HP:0100646)3.74532014
14Chronic otitis media (HP:0000389)3.64431493
15Increased IgM level (HP:0003496)3.63358112
16Panhypogammaglobulinemia (HP:0003139)3.61619653
17Autoimmune thrombocytopenia (HP:0001973)3.60952721
18Abnormality of B cell number (HP:0010975)3.56491197
19B lymphocytopenia (HP:0010976)3.56491197
20Abnormality of the heme biosynthetic pathway (HP:0010472)3.52225812
21Elevated erythrocyte sedimentation rate (HP:0003565)3.47052036
22Osteomyelitis (HP:0002754)3.44088734
23Recurrent gram-negative bacterial infections (HP:0005420)3.33473582
24Gastrointestinal inflammation (HP:0004386)3.30997894
25T lymphocytopenia (HP:0005403)3.28734648
26Inflammation of the large intestine (HP:0002037)3.27965576
27Abnormality of T cells (HP:0002843)3.21375084
28Abnormality of T cell number (HP:0011839)3.20170062
29Myositis (HP:0100614)3.20144930
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.17287226
31Severe combined immunodeficiency (HP:0004430)3.16394936
32Petechiae (HP:0000967)3.15041352
33Combined immunodeficiency (HP:0005387)3.14588717
34Colitis (HP:0002583)3.10374798
35Recurrent skin infections (HP:0001581)3.09875215
36Interstitial pulmonary disease (HP:0006530)3.06626243
37Obstructive lung disease (HP:0006536)3.05112938
38Chronic obstructive pulmonary disease (HP:0006510)3.05112938
39Purpura (HP:0000979)3.03248016
40Abnormality of T cell physiology (HP:0011840)3.02712473
41Sepsis (HP:0100806)3.00829002
42Mediastinal lymphadenopathy (HP:0100721)2.97268081
43Chronic mucocutaneous candidiasis (HP:0002728)2.96578426
44Recurrent cutaneous fungal infections (HP:0011370)2.96578426
45Pustule (HP:0200039)2.96327604
46Thrombocytosis (HP:0001894)2.92340030
47Gastrointestinal infarctions (HP:0005244)2.92337444
48Vacuolated lymphocytes (HP:0001922)2.91274564
49Abnormality of macrophages (HP:0004311)2.91252955
50Spontaneous hematomas (HP:0007420)2.88681610
51Recurrent pneumonia (HP:0006532)2.85992032
52Lymphopenia (HP:0001888)2.76552990
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.75275798
54Vasculitis (HP:0002633)2.74207346
55Prolonged bleeding time (HP:0003010)2.70171332
56Abnormality of the prostate (HP:0008775)2.68745914
57Nasal polyposis (HP:0100582)2.65152705
58Recurrent lower respiratory tract infections (HP:0002783)2.61991908
59Abnormality of the fingertips (HP:0001211)2.61586923
60Chronic sinusitis (HP:0011109)2.59200340
61Abnormality of the nasal mucosa (HP:0000433)2.57049346
62Increased serum ferritin (HP:0003281)2.54755459
63IgG deficiency (HP:0004315)2.50398354
64Eosinophilia (HP:0001880)2.48439549
65Leukocytosis (HP:0001974)2.43987952
66Gingival bleeding (HP:0000225)2.43868811
67Increased IgE level (HP:0003212)2.42922653
68Abnormality of iron homeostasis (HP:0011031)2.40843196
69Gastrointestinal stroma tumor (HP:0100723)2.38581009
70Gingivitis (HP:0000230)2.37154945
71Recurrent otitis media (HP:0000403)2.37106467
72Increased cerebral lipofuscin (HP:0011813)2.36457933
73Skin ulcer (HP:0200042)2.31354534
74Aplastic anemia (HP:0001915)2.31331095
75Chronic diarrhea (HP:0002028)2.30984284
76Bronchitis (HP:0012387)2.30354672
77Keratoconjunctivitis sicca (HP:0001097)2.29828209
78Hematochezia (HP:0002573)2.29428532
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.28652855
80Granulocytopenia (HP:0001913)2.28396032
81Periodontitis (HP:0000704)2.26698018
82Hypochromic microcytic anemia (HP:0004840)2.26341817
83Hepatosplenomegaly (HP:0001433)2.25971684
84Hypertensive crisis (HP:0100735)2.25809205
85Hypochromic anemia (HP:0001931)2.25526247
86Orchitis (HP:0100796)2.25467581
87Recurrent sinusitis (HP:0011108)2.25428786
88Hypoplasia of the thymus (HP:0000778)2.24232395
89Skin rash (HP:0000988)2.24202514
90Abnormality of eosinophils (HP:0001879)2.23385388
91Microcytic anemia (HP:0001935)2.21991537
92Keratoconjunctivitis (HP:0001096)2.21439241
93Abnormal number of erythroid precursors (HP:0012131)2.21122386
94Urticaria (HP:0001025)2.21076503
95Bronchiectasis (HP:0002110)2.20098543
96Lymphoma (HP:0002665)2.19322482
97Anorexia (HP:0002039)2.18209437
98Increased neuronal autofluorescent lipopigment (HP:0002074)2.16602967
99Dysostosis multiplex (HP:0000943)2.15122275
100Epistaxis (HP:0000421)2.14387553
101Dynein arm defect of respiratory motile cilia (HP:0012255)2.11848284
102Absent/shortened dynein arms (HP:0200106)2.11848284
103Abnormality of cells of the erythroid lineage (HP:0012130)2.10419865
104Abnormal respiratory epithelium morphology (HP:0012253)2.09567382
105Abnormal respiratory motile cilium morphology (HP:0005938)2.09567382
106Systemic lupus erythematosus (HP:0002725)2.07035945
107IgA deficiency (HP:0002720)2.06436662
108Autoimmune hemolytic anemia (HP:0001890)2.04863279
109Hemoptysis (HP:0002105)2.03337424
110Impaired platelet aggregation (HP:0003540)1.99394157
111Abnormal platelet function (HP:0011869)1.99394157
112Optic neuritis (HP:0100653)1.96785756
113Retrobulbar optic neuritis (HP:0100654)1.96785756
114Emphysema (HP:0002097)1.94686732
115Reticulocytopenia (HP:0001896)1.89736369
116Chest pain (HP:0100749)1.89107192
117Arterial thrombosis (HP:0004420)1.87723492
118Mucopolysacchariduria (HP:0008155)1.87454815
119Urinary glycosaminoglycan excretion (HP:0003541)1.87454815
120Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87079592
121Stomatitis (HP:0010280)1.86295065
122Pulmonary infiltrates (HP:0002113)1.85932976
123Encephalitis (HP:0002383)1.82867790
124Restrictive lung disease (HP:0002091)1.82071774
125Hypergammaglobulinemia (HP:0010702)1.79844680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.77625814
2MAP4K14.33527418
3EEF2K3.22526928
4ERN13.20670302
5BLK2.55169864
6STK102.23715156
7TYK22.15488799
8ZAP702.09689071
9VRK22.07810330
10BTK2.02036314
11TBK12.01527342
12TRIB31.97182400
13GRK61.94370484
14PKN21.82057970
15SYK1.81148047
16JAK31.73281316
17IKBKE1.64778829
18CSF1R1.63876046
19TXK1.60542413
20LRRK21.57234159
21RIPK41.55664072
22IRAK41.54023680
23KIT1.52559222
24TEC1.42320524
25PRPF4B1.39314949
26NME21.33895207
27CLK11.32605868
28PIM21.32049157
29TGFBR21.31976540
30FLT31.31356765
31TAOK21.30775512
32PIM11.29631667
33STK41.29150280
34ITK1.29148046
35SCYL21.27252964
36CDK121.26386582
37NEK21.23160816
38BMPR21.22724379
39TESK21.22475535
40MAP3K141.19144121
41NLK1.19091229
42JAK11.18581488
43MST41.18395975
44CSK1.17309504
45TAOK31.16785213
46HCK1.16541203
47LCK1.14349943
48KDR1.13969821
49LYN1.11830111
50RPS6KA41.11195970
51IKBKB1.11127406
52SIK21.10904478
53PRKCQ1.10725082
54CDK41.06965410
55MAP3K130.99375925
56MAP2K30.98640113
57FES0.96830912
58SMG10.96675670
59RPS6KB20.95894785
60MAP3K120.95663485
61EIF2AK10.93350217
62BCKDK0.91914367
63MAPK110.87546776
64FGFR30.85140735
65HIPK20.85135424
66FGFR40.84189119
67EPHB10.82563382
68MAPKAPK30.82344935
69CDK60.81405447
70IRAK30.79613861
71JAK20.77693150
72CHUK0.77630391
73MARK30.77423056
74FGR0.72153271
75CDC70.71857854
76PASK0.71406287
77MAP3K110.70839322
78PTK60.69891412
79PIK3CG0.68642186
80DYRK1B0.65795367
81MAPK40.64282320
82GRK70.64217809
83MAPKAPK20.64186228
84MAP3K80.64175937
85DAPK10.63034750
86TESK10.62212049
87MAPK150.62195446
88CAMKK20.59698936
89PAK40.57874537
90FYN0.57064645
91TRPM70.56564325
92MAP3K10.56395557
93PDK10.56244406
94BMX0.54835111
95MAP3K50.54714835
96MAP2K60.54588959
97TGFBR10.54120671
98TLK10.53757042
99NUAK10.53127953
100ADRBK20.51223339
101CDK90.49706681
102NEK90.49512859
103EIF2AK30.48686645
104RPS6KA60.48320148
105MATK0.44941329
106CAMKK10.44681443
107STK160.44523291
108MAP3K30.44369949
109VRK10.43947857
110TNK20.43603591
111PTK2B0.42909753
112RIPK10.42054818
113RPS6KC10.40907438
114RPS6KL10.40907438
115DYRK30.39147548
116MAPK120.38910767
117MAP3K70.37153199
118STK240.36875796
119ATR0.36302972
120SIK30.35093246
121CDK70.34336732
122ILK0.32990135
123ABL10.32409165
124SIK10.32012760
125PRKCH0.31682101
126GRK50.31635613
127PRKCD0.31582445
128BRD40.30209906
129TAOK10.29267913
130AURKB0.28881032
131MAP2K20.28751973
132PAK10.28624850
133MAPK70.25081492
134ZAK0.24269227
135ARAF0.23890032
136PRKD20.23756620
137PDPK10.23687459
138MAP4K20.22928994

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.19634248
2B cell receptor signaling pathway_Homo sapiens_hsa046622.78798846
3Leishmaniasis_Homo sapiens_hsa051402.60499392
4DNA replication_Homo sapiens_hsa030302.49678174
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.22106773
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.16321941
7Osteoclast differentiation_Homo sapiens_hsa043802.15812830
8Measles_Homo sapiens_hsa051622.07073497
9Hematopoietic cell lineage_Homo sapiens_hsa046402.00176927
10Antigen processing and presentation_Homo sapiens_hsa046121.99140528
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80008138
12Base excision repair_Homo sapiens_hsa034101.76001561
13Proteasome_Homo sapiens_hsa030501.74723070
14Other glycan degradation_Homo sapiens_hsa005111.71550573
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71369593
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68828988
17Mismatch repair_Homo sapiens_hsa034301.68637022
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66375346
19Herpes simplex infection_Homo sapiens_hsa051681.62348029
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54885850
21Legionellosis_Homo sapiens_hsa051341.53328304
22Ribosome_Homo sapiens_hsa030101.51273540
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50743945
24Non-homologous end-joining_Homo sapiens_hsa034501.49829101
25T cell receptor signaling pathway_Homo sapiens_hsa046601.49440288
26Tuberculosis_Homo sapiens_hsa051521.49074515
27Toxoplasmosis_Homo sapiens_hsa051451.45129259
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43395488
29Shigellosis_Homo sapiens_hsa051311.43361084
30Apoptosis_Homo sapiens_hsa042101.41494948
31Chronic myeloid leukemia_Homo sapiens_hsa052201.41233082
32Pertussis_Homo sapiens_hsa051331.40591965
33Acute myeloid leukemia_Homo sapiens_hsa052211.40065420
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.37817097
35Staphylococcus aureus infection_Homo sapiens_hsa051501.35542893
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.35524419
37Influenza A_Homo sapiens_hsa051641.30401072
38Hepatitis B_Homo sapiens_hsa051611.29163796
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24593828
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24254824
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.20299818
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19573046
43Lysosome_Homo sapiens_hsa041421.19553736
44Malaria_Homo sapiens_hsa051441.19517611
45Chemokine signaling pathway_Homo sapiens_hsa040621.16637814
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13603828
47Homologous recombination_Homo sapiens_hsa034401.10174921
48Allograft rejection_Homo sapiens_hsa053301.07372060
49Pancreatic cancer_Homo sapiens_hsa052121.07019332
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05745509
51Viral myocarditis_Homo sapiens_hsa054161.02478251
52Salmonella infection_Homo sapiens_hsa051321.02325374
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01486848
54Viral carcinogenesis_Homo sapiens_hsa052030.99625356
55Platelet activation_Homo sapiens_hsa046110.98584824
56Asthma_Homo sapiens_hsa053100.97796718
57Epstein-Barr virus infection_Homo sapiens_hsa051690.95308685
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94839716
59TNF signaling pathway_Homo sapiens_hsa046680.94398180
60p53 signaling pathway_Homo sapiens_hsa041150.93241437
61HTLV-I infection_Homo sapiens_hsa051660.91198379
62Cell cycle_Homo sapiens_hsa041100.91126363
63Non-small cell lung cancer_Homo sapiens_hsa052230.87590325
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85263416
65Graft-versus-host disease_Homo sapiens_hsa053320.84397855
66Spliceosome_Homo sapiens_hsa030400.83468254
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83221739
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77529204
69Small cell lung cancer_Homo sapiens_hsa052220.75580943
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74032118
71Nucleotide excision repair_Homo sapiens_hsa034200.73300876
72Hepatitis C_Homo sapiens_hsa051600.73264716
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71202938
74Pentose phosphate pathway_Homo sapiens_hsa000300.70181717
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.70068136
76Collecting duct acid secretion_Homo sapiens_hsa049660.64712962
77African trypanosomiasis_Homo sapiens_hsa051430.63699468
78VEGF signaling pathway_Homo sapiens_hsa043700.61927509
79Prolactin signaling pathway_Homo sapiens_hsa049170.61790207
80Caffeine metabolism_Homo sapiens_hsa002320.59675007
81Colorectal cancer_Homo sapiens_hsa052100.59593355
82Systemic lupus erythematosus_Homo sapiens_hsa053220.59458212
83Oxidative phosphorylation_Homo sapiens_hsa001900.57902583
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57197086
85Renin-angiotensin system_Homo sapiens_hsa046140.56019575
86Autoimmune thyroid disease_Homo sapiens_hsa053200.54335176
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54188880
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53185267
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52814527
90Phagosome_Homo sapiens_hsa041450.52034268
91Regulation of autophagy_Homo sapiens_hsa041400.51774734
92Pyrimidine metabolism_Homo sapiens_hsa002400.51003658
93Parkinsons disease_Homo sapiens_hsa050120.49447782
94Insulin resistance_Homo sapiens_hsa049310.49185680
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46484937
96Thyroid cancer_Homo sapiens_hsa052160.46268871
97Rheumatoid arthritis_Homo sapiens_hsa053230.45018102
98Notch signaling pathway_Homo sapiens_hsa043300.44643491
99N-Glycan biosynthesis_Homo sapiens_hsa005100.43688696
100FoxO signaling pathway_Homo sapiens_hsa040680.42122915
101Sulfur relay system_Homo sapiens_hsa041220.41500612
102Arachidonic acid metabolism_Homo sapiens_hsa005900.39363810
103Endocytosis_Homo sapiens_hsa041440.39315400
104HIF-1 signaling pathway_Homo sapiens_hsa040660.39302652
105MicroRNAs in cancer_Homo sapiens_hsa052060.37613177
106Type I diabetes mellitus_Homo sapiens_hsa049400.34898210
107Fanconi anemia pathway_Homo sapiens_hsa034600.33771788
108Protein export_Homo sapiens_hsa030600.33576901
109Amoebiasis_Homo sapiens_hsa051460.32995479
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32878067
111Prostate cancer_Homo sapiens_hsa052150.32304866
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.31417502
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.31197291
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29408122
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29398148
116Huntingtons disease_Homo sapiens_hsa050160.28548899
117Glutathione metabolism_Homo sapiens_hsa004800.26253732
118RNA polymerase_Homo sapiens_hsa030200.26244057
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26075817
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25720879
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24465275
122Sulfur metabolism_Homo sapiens_hsa009200.17127961
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.17073273
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.15778776
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14747792
126Purine metabolism_Homo sapiens_hsa002300.12159766
127Alzheimers disease_Homo sapiens_hsa050100.08627352

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