UFC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.15935445
2cilium movement (GO:0003341)6.75427203
3cilium or flagellum-dependent cell motility (GO:0001539)6.54281990
4epithelial cilium movement (GO:0003351)6.52539852
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.37942408
6motile cilium assembly (GO:0044458)5.64190300
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.26243201
8viral transcription (GO:0019083)5.19469867
9axoneme assembly (GO:0035082)5.04239431
10translational termination (GO:0006415)4.98395598
11signal peptide processing (GO:0006465)4.97216943
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.90707547
13ATP synthesis coupled proton transport (GO:0015986)4.90707547
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.71049885
15L-phenylalanine catabolic process (GO:0006559)4.71049885
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.70022654
17L-phenylalanine metabolic process (GO:0006558)4.70022654
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.62385976
19Golgi transport vesicle coating (GO:0048200)4.60245630
20COPI coating of Golgi vesicle (GO:0048205)4.60245630
21ribosomal small subunit biogenesis (GO:0042274)4.31005485
22translational elongation (GO:0006414)4.30124295
23regulation of cilium movement (GO:0003352)4.29868112
24respiratory electron transport chain (GO:0022904)4.22874095
25electron transport chain (GO:0022900)4.16083787
26GDP-mannose metabolic process (GO:0019673)4.07467782
27protein maturation by protein folding (GO:0022417)4.01490200
28viral life cycle (GO:0019058)3.95657364
29aldehyde catabolic process (GO:0046185)3.88933760
30cellular protein complex disassembly (GO:0043624)3.83554763
31maturation of SSU-rRNA (GO:0030490)3.80959685
32translational initiation (GO:0006413)3.75316617
33protein complex biogenesis (GO:0070271)3.66113483
34aromatic amino acid family catabolic process (GO:0009074)3.61059872
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.57216530
36rRNA modification (GO:0000154)3.56422907
37left/right pattern formation (GO:0060972)3.54479993
38intraciliary transport (GO:0042073)3.53389631
39termination of RNA polymerase III transcription (GO:0006386)3.50667553
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.50667553
41proton transport (GO:0015992)3.49675863
42primary alcohol catabolic process (GO:0034310)3.48600577
43regulation of cellular amino acid metabolic process (GO:0006521)3.48552780
44chaperone-mediated protein transport (GO:0072321)3.47528807
45glutathione derivative biosynthetic process (GO:1901687)3.44460118
46glutathione derivative metabolic process (GO:1901685)3.44460118
47nucleoside diphosphate phosphorylation (GO:0006165)3.43387514
48hydrogen transport (GO:0006818)3.41897716
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.41105322
50ribosomal large subunit biogenesis (GO:0042273)3.40743522
51mitochondrial respiratory chain complex assembly (GO:0033108)3.40110557
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38457965
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.38457965
54NADH dehydrogenase complex assembly (GO:0010257)3.38457965
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.32984052
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.30214002
57cotranslational protein targeting to membrane (GO:0006613)3.28963807
58ribonucleoside triphosphate biosynthetic process (GO:0009201)3.26472866
59protein targeting to ER (GO:0045047)3.25558559
60proteasome assembly (GO:0043248)3.23912648
61negative regulation of T cell differentiation in thymus (GO:0033085)3.23834593
62protein localization to endoplasmic reticulum (GO:0070972)3.21071692
63regulation of mitochondrial translation (GO:0070129)3.20967073
64amino acid salvage (GO:0043102)3.20768096
65L-methionine salvage (GO:0071267)3.20768096
66L-methionine biosynthetic process (GO:0071265)3.20768096
67nucleoside triphosphate biosynthetic process (GO:0009142)3.19572620
68oxidative phosphorylation (GO:0006119)3.18471407
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17380770
70regulation of oxidative phosphorylation (GO:0002082)3.15177847
71protein retention in ER lumen (GO:0006621)3.14329251
72protein neddylation (GO:0045116)3.13826062
73protein targeting to membrane (GO:0006612)3.12148610
74branched-chain amino acid catabolic process (GO:0009083)3.11954804
75sulfur amino acid catabolic process (GO:0000098)3.11056125
76antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.10542747
77NADH metabolic process (GO:0006734)3.08345365
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07496062
79establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06919956
80left/right axis specification (GO:0070986)3.06060737
81protein complex disassembly (GO:0043241)3.05775108
82aerobic respiration (GO:0009060)3.04213785
83cilium organization (GO:0044782)3.02300496
84coenzyme catabolic process (GO:0009109)3.01248234
85bile acid biosynthetic process (GO:0006699)3.01069323
86cullin deneddylation (GO:0010388)2.99780669
87protein deneddylation (GO:0000338)2.99534304
88aromatic amino acid family metabolic process (GO:0009072)2.99079780
89UTP biosynthetic process (GO:0006228)2.98968151
90cysteine metabolic process (GO:0006534)2.96578317
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96206606
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96206606
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94213300
94macromolecular complex disassembly (GO:0032984)2.92327048
95cofactor catabolic process (GO:0051187)2.92273643
96guanosine-containing compound biosynthetic process (GO:1901070)2.92159141
97nucleotide-sugar biosynthetic process (GO:0009226)2.91086530
98rRNA methylation (GO:0031167)2.91006064
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90208258
100glyoxylate metabolic process (GO:0046487)2.90022852
101positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89861880
102antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.88501282
103cilium assembly (GO:0042384)2.88363043
104establishment of protein localization to mitochondrial membrane (GO:0090151)2.88226844
105COPII vesicle coating (GO:0048208)2.88030340
106platelet dense granule organization (GO:0060155)2.87513104
107water-soluble vitamin biosynthetic process (GO:0042364)2.87104677
108intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86911547
109signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86911547
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85414268
111nucleotide transmembrane transport (GO:1901679)2.85241732
112fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.85102493
113signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84126089
114signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84126089
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84126089
116response to xenobiotic stimulus (GO:0009410)2.83850510
117oxaloacetate metabolic process (GO:0006107)2.82452679
118translation (GO:0006412)2.82017634
119positive regulation of ligase activity (GO:0051351)2.81604116
120negative regulation of ligase activity (GO:0051352)2.81326823
121negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81326823
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79709222
123peroxisome fission (GO:0016559)2.79549133
124cellular component biogenesis (GO:0044085)2.78793929
125regulation of cellular amine metabolic process (GO:0033238)2.78446544
126pteridine-containing compound biosynthetic process (GO:0042559)2.77427611
127intestinal cholesterol absorption (GO:0030299)2.77254045
128valine metabolic process (GO:0006573)2.76760500
129signal transduction involved in DNA damage checkpoint (GO:0072422)2.75842573
130signal transduction involved in DNA integrity checkpoint (GO:0072401)2.75842573
131purine nucleoside triphosphate biosynthetic process (GO:0009145)2.75396623
132branched-chain amino acid metabolic process (GO:0009081)2.75124780
133ribosomal small subunit assembly (GO:0000028)2.74872326
134signal transduction involved in cell cycle checkpoint (GO:0072395)2.72181554
135nucleoside diphosphate biosynthetic process (GO:0009133)2.71419101
136peptidyl-histidine modification (GO:0018202)2.70752413
137ATP biosynthetic process (GO:0006754)2.66881101
138respiratory chain complex IV assembly (GO:0008535)2.66688202
139purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.66513209
140cellular ketone body metabolic process (GO:0046950)2.65348678
141GTP biosynthetic process (GO:0006183)2.65225586
142bile acid metabolic process (GO:0008206)2.63331999
143indole-containing compound catabolic process (GO:0042436)2.63114869
144indolalkylamine catabolic process (GO:0046218)2.63114869
145tryptophan catabolic process (GO:0006569)2.63114869
146formation of translation preinitiation complex (GO:0001731)2.62281670
147tyrosine metabolic process (GO:0006570)2.62045861
148regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61755703
149alpha-linolenic acid metabolic process (GO:0036109)2.61713134
150hydrogen ion transmembrane transport (GO:1902600)2.61385978
151cytochrome complex assembly (GO:0017004)2.59980260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.68244579
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.60670104
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.45728802
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.12109852
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.01728715
6PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.56634960
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.56383993
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.47241022
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.43187824
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.30101405
11* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07600474
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.00457303
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.88989605
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77491458
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.66955129
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.65951629
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.60520946
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60068293
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58440988
20PPARA_22158963_ChIP-Seq_LIVER_Mouse2.55817024
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.55233416
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.47337008
23* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39943046
24DCP1A_22483619_ChIP-Seq_HELA_Human2.39236623
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37885026
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31848504
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25789749
28VDR_23849224_ChIP-Seq_CD4+_Human2.22366544
29VDR_22108803_ChIP-Seq_LS180_Human2.17137826
30* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16926266
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98532900
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.98296283
33* GABP_19822575_ChIP-Seq_HepG2_Human1.92013993
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89668554
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.81781988
36* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79178424
37XRN2_22483619_ChIP-Seq_HELA_Human1.77506129
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.77356857
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76728061
40FOXP3_21729870_ChIP-Seq_TREG_Human1.74029574
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73565228
42* YY1_21170310_ChIP-Seq_MESCs_Mouse1.70643069
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69731075
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66590837
45* ELK1_19687146_ChIP-ChIP_HELA_Human1.66463535
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59646104
47MYC_18940864_ChIP-ChIP_HL60_Human1.55241013
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52675692
49* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51728963
50* ELK1_22589737_ChIP-Seq_MCF10A_Human1.50554707
51* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50241427
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49071917
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45935408
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44014130
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.44011675
56ZNF274_21170338_ChIP-Seq_K562_Hela1.41761435
57STAT1_20625510_ChIP-Seq_HELA_Human1.40845781
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40726465
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37491677
60SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.37441378
61TTF2_22483619_ChIP-Seq_HELA_Human1.37181670
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35987680
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33450323
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.32817596
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32817596
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32361779
67CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.32017406
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31900222
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29073644
70GATA6_21074721_ChIP-Seq_CACO-2_Human1.28491071
71ELF5_23300383_ChIP-Seq_T47D_Human1.27578515
72GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.25187151
73RBPJ_21746931_ChIP-Seq_IB4_Human1.18920795
74* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16734814
75PHF8_20622853_ChIP-Seq_HELA_Human1.16582210
76CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10988831
77* SOX17_20123909_ChIP-Seq_XEN_Mouse1.10369411
78TP53_22573176_ChIP-Seq_HFKS_Human1.09244996
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08990037
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08834235
81EWS_26573619_Chip-Seq_HEK293_Human1.07992265
82TFEB_21752829_ChIP-Seq_HELA_Human1.05103718
83* NCOR_22424771_ChIP-Seq_293T_Human1.04176020
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.03893077
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02356598
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01935527
87NANOG_20526341_ChIP-Seq_ESCs_Human1.01510638
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00394410
89CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99867294
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99065873
91FUS_26573619_Chip-Seq_HEK293_Human0.98636052
92* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97787179
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97725057
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96972576
95HNFA_21074721_ChIP-Seq_CACO-2_Human0.96350448
96ERG_20517297_ChIP-Seq_VCAP_Human0.94272645
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93119401
98ETV1_20927104_ChIP-Seq_GIST48_Human0.93099502
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92198268
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91619113
101MYC_19829295_ChIP-Seq_ESCs_Human0.91173886
102GATA3_26560356_Chip-Seq_TH2_Human0.91081626
103TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90886684
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90813891
105PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89678085
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89155903
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89021570
108GATA3_21878914_ChIP-Seq_MCF-7_Human0.89017278
109SOX2_19829295_ChIP-Seq_ESCs_Human0.88179313
110NANOG_19829295_ChIP-Seq_ESCs_Human0.88179313
111MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88048615
112FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87408400
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87110717
114ELF1_20517297_ChIP-Seq_JURKAT_Human0.86986845
115PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86884137
116P300_27268052_Chip-Seq_Bcells_Human0.86530624
117NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86376172
118* KDM5A_27292631_Chip-Seq_BREAST_Human0.86209412
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85529185
120CLOCK_20551151_ChIP-Seq_293T_Human0.83692017
121* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82031066
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81429364
123IRF1_19129219_ChIP-ChIP_H3396_Human0.79965554
124* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79518426
125* SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77348822
126OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75370385
127HTT_18923047_ChIP-ChIP_STHdh_Human0.74531405
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72998484
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.71658666
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70820283
131* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.70059028
132AR_20517297_ChIP-Seq_VCAP_Human0.69871935
133YY1_22570637_ChIP-Seq_MALME-3M_Human0.69479765
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69196137
135ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.66589989
136GATA1_22025678_ChIP-Seq_K562_Human0.66478525
137REST_19997604_ChIP-ChIP_NEURONS_Mouse0.65749898
138* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.65735315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.54925487
2MP0003806_abnormal_nucleotide_metabolis4.81428273
3MP0005365_abnormal_bile_salt4.38741251
4MP0005085_abnormal_gallbladder_physiolo4.23122049
5MP0005360_urolithiasis3.61351438
6MP0003195_calcinosis3.49627681
7MP0008875_abnormal_xenobiotic_pharmacok3.35843023
8MP0002653_abnormal_ependyma_morphology3.26447194
9MP0005083_abnormal_biliary_tract3.14281600
10MP0001666_abnormal_nutrient_absorption2.82560274
11MP0003186_abnormal_redox_activity2.68476764
12MP0006036_abnormal_mitochondrial_physio2.57723698
13MP0002837_dystrophic_cardiac_calcinosis2.57140363
14MP0004043_abnormal_pH_regulation2.56797510
15MP0005332_abnormal_amino_acid2.47058259
16MP0010386_abnormal_urinary_bladder2.46203079
17MP0002876_abnormal_thyroid_physiology2.41463995
18MP0002132_abnormal_respiratory_system2.40833987
19MP0001764_abnormal_homeostasis2.31735156
20MP0009840_abnormal_foam_cell2.15218052
21MP0003868_abnormal_feces_composition2.12906574
22MP0005220_abnormal_exocrine_pancreas2.11026882
23MP0010329_abnormal_lipoprotein_level2.05089357
24MP0005379_endocrine/exocrine_gland_phen2.05003957
25MP0005084_abnormal_gallbladder_morpholo2.02077501
26MP0002693_abnormal_pancreas_physiology1.97471372
27MP0003136_yellow_coat_color1.97208597
28MP0008995_early_reproductive_senescence1.94560941
29MP0005075_abnormal_melanosome_morpholog1.88099912
30MP0005646_abnormal_pituitary_gland1.85623484
31MP0003786_premature_aging1.85496136
32MP0005636_abnormal_mineral_homeostasis1.84212442
33MP0009643_abnormal_urine_homeostasis1.78664125
34MP0001944_abnormal_pancreas_morphology1.75154706
35MP0005408_hypopigmentation1.74573715
36MP0009697_abnormal_copulation1.73333241
37MP0003183_abnormal_peptide_metabolism1.67712750
38MP0002118_abnormal_lipid_homeostasis1.67294055
39MP0005319_abnormal_enzyme/_coenzyme1.65659308
40MP0002938_white_spotting1.64929560
41MP0002138_abnormal_hepatobiliary_system1.64884469
42MP0003252_abnormal_bile_duct1.63332916
43MP0004019_abnormal_vitamin_homeostasis1.63093782
44MP0008789_abnormal_olfactory_epithelium1.58425022
45MP0003011_delayed_dark_adaptation1.56249429
46MP0001835_abnormal_antigen_presentation1.55014633
47MP0000013_abnormal_adipose_tissue1.54453338
48MP0006035_abnormal_mitochondrial_morpho1.54367765
49MP0002160_abnormal_reproductive_system1.53135505
50MP0002078_abnormal_glucose_homeostasis1.51733343
51MP0005551_abnormal_eye_electrophysiolog1.51001085
52MP0008058_abnormal_DNA_repair1.49995686
53MP0004133_heterotaxia1.47440619
54MP0002163_abnormal_gland_morphology1.47387239
55MP0005253_abnormal_eye_physiology1.47253362
56MP0005174_abnormal_tail_pigmentation1.45961715
57MP0001984_abnormal_olfaction1.43844253
58MP0002102_abnormal_ear_morphology1.43430560
59MP0002877_abnormal_melanocyte_morpholog1.41714270
60MP0000609_abnormal_liver_physiology1.41095113
61MP0004782_abnormal_surfactant_physiolog1.40836515
62MP0001986_abnormal_taste_sensitivity1.39435176
63MP0002148_abnormal_hypersensitivity_rea1.37834327
64MP0001756_abnormal_urination1.37164354
65MP0003191_abnormal_cellular_cholesterol1.36220326
66MP0005671_abnormal_response_to1.35923621
67MP0005584_abnormal_enzyme/coenzyme_acti1.33901630
68MP0001542_abnormal_bone_strength1.32231829
69MP0002638_abnormal_pupillary_reflex1.31589001
70MP0001529_abnormal_vocalization1.31334245
71MP0001346_abnormal_lacrimal_gland1.28427713
72MP0005535_abnormal_body_temperature1.28101227
73MP0003959_abnormal_lean_body1.25758670
74MP0001485_abnormal_pinna_reflex1.24651220
75MP0008872_abnormal_physiological_respon1.23909090
76MP0005058_abnormal_lysosome_morphology1.23565142
77MP0003718_maternal_effect1.20172283
78MP0009333_abnormal_splenocyte_physiolog1.19438925
79MP0002095_abnormal_skin_pigmentation1.18206630
80MP0009379_abnormal_foot_pigmentation1.13945994
81MP0001905_abnormal_dopamine_level1.13887886
82MP0002736_abnormal_nociception_after1.13520259
83MP0006276_abnormal_autonomic_nervous1.10989763
84MP0004147_increased_porphyrin_level1.10111172
85MP0003878_abnormal_ear_physiology1.09161700
86MP0005377_hearing/vestibular/ear_phenot1.09161700
87MP0006082_CNS_inflammation1.05726641
88MP0002282_abnormal_trachea_morphology1.03248518
89MP0005451_abnormal_body_composition1.00855574
90MP0001853_heart_inflammation0.99492105
91MP0001929_abnormal_gametogenesis0.96887386
92MP0000538_abnormal_urinary_bladder0.96506514
93MP0001765_abnormal_ion_homeostasis0.95796085
94MP0005376_homeostasis/metabolism_phenot0.95700518
95MP0009642_abnormal_blood_homeostasis0.94982392
96MP0003953_abnormal_hormone_level0.94959748
97MP0003656_abnormal_erythrocyte_physiolo0.92428224
98MP0001968_abnormal_touch/_nociception0.92239243
99MP0008007_abnormal_cellular_replicative0.91827128
100MP0008469_abnormal_protein_level0.90476813
101MP0000678_abnormal_parathyroid_gland0.89104705
102MP0005310_abnormal_salivary_gland0.89058397
103MP0002909_abnormal_adrenal_gland0.88507929
104MP0005645_abnormal_hypothalamus_physiol0.88244803
105MP0003693_abnormal_embryo_hatching0.86294996
106MP0005266_abnormal_metabolism0.84310420
107MP0000685_abnormal_immune_system0.83694300
108MP0000358_abnormal_cell_content/0.83246975
109MP0000631_abnormal_neuroendocrine_gland0.81051871
110MP0001348_abnormal_lacrimal_gland0.80758390
111MP0009046_muscle_twitch0.80617060
112MP0003866_abnormal_defecation0.80294638
113MP0005395_other_phenotype0.80263137
114MP0000230_abnormal_systemic_arterial0.79192796
115MP0001293_anophthalmia0.78022034
116MP0000598_abnormal_liver_morphology0.77993876
117MP0000681_abnormal_thyroid_gland0.77562438
118MP0000613_abnormal_salivary_gland0.77262756
119MP0005448_abnormal_energy_balance0.77249544
120MP0010155_abnormal_intestine_physiology0.75784222
121MP0009765_abnormal_xenobiotic_induced0.73458019
122MP0006292_abnormal_olfactory_placode0.72887643
123MP0005387_immune_system_phenotype0.71650722
124MP0001790_abnormal_immune_system0.71650722
125MP0004142_abnormal_muscle_tone0.71095196
126MP0005410_abnormal_fertilization0.70077553
127MP0001664_abnormal_digestion0.69028042
128MP0001501_abnormal_sleep_pattern0.68220526
129MP0001919_abnormal_reproductive_system0.67360322
130MP0001873_stomach_inflammation0.65903955
131MP0002210_abnormal_sex_determination0.65774600
132MP0002405_respiratory_system_inflammati0.65697991
133MP0002090_abnormal_vision0.65328230
134MP0001145_abnormal_male_reproductive0.65059080
135MP0001661_extended_life_span0.62620677
136MP0003638_abnormal_response/metabolism_0.59638556
137MP0006072_abnormal_retinal_apoptosis0.58311296
138MP0002295_abnormal_pulmonary_circulatio0.54622433
139MP0009780_abnormal_chondrocyte_physiolo0.54538192
140MP0005334_abnormal_fat_pad0.54211722
141MP0001845_abnormal_inflammatory_respons0.53841193
142MP0002277_abnormal_respiratory_mucosa0.53643417
143MP0005389_reproductive_system_phenotype0.53237380
144MP0009764_decreased_sensitivity_to0.52908341
145MP0008260_abnormal_autophagy0.52159354
146MP0001881_abnormal_mammary_gland0.51495166
147MP0004957_abnormal_blastocyst_morpholog0.51096565
148MP0002136_abnormal_kidney_physiology0.48582027
149MP0000639_abnormal_adrenal_gland0.48419828
150MP0003879_abnormal_hair_cell0.47711312
151MP0002734_abnormal_mechanical_nocicepti0.47127279
152MP0008873_increased_physiological_sensi0.46481352
153MP0000372_irregular_coat_pigmentation0.45812976
154MP0009785_altered_susceptibility_to0.45616225
155MP0002733_abnormal_thermal_nociception0.45560889

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.09935886
2Abnormal respiratory motile cilium physiology (HP:0012261)7.21104803
3Abnormal respiratory epithelium morphology (HP:0012253)7.18191622
4Abnormal respiratory motile cilium morphology (HP:0005938)7.18191622
5Dynein arm defect of respiratory motile cilia (HP:0012255)6.98140146
6Absent/shortened dynein arms (HP:0200106)6.98140146
7Abnormal ciliary motility (HP:0012262)6.91081746
8Rhinitis (HP:0012384)6.58596872
9Chronic bronchitis (HP:0004469)5.27065680
10Abnormality of aromatic amino acid family metabolism (HP:0004338)5.13888324
11Acute necrotizing encephalopathy (HP:0006965)5.01004804
12Bronchiectasis (HP:0002110)4.88686386
13Abnormal mitochondria in muscle tissue (HP:0008316)4.75943958
14Acute encephalopathy (HP:0006846)4.70575336
15Mitochondrial inheritance (HP:0001427)4.35666629
16Hepatic necrosis (HP:0002605)4.34136050
17Hypoglycemic coma (HP:0001325)4.13436589
18Progressive macrocephaly (HP:0004481)4.12888630
19Hepatocellular necrosis (HP:0001404)4.05896079
20Cerebral edema (HP:0002181)3.98252986
21Increased CSF lactate (HP:0002490)3.88424237
22Nasal polyposis (HP:0100582)3.74225722
23Pancreatic fibrosis (HP:0100732)3.63445708
24True hermaphroditism (HP:0010459)3.60119571
25Pancreatic cysts (HP:0001737)3.40979822
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.40155103
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.40155103
28Abnormality of midbrain morphology (HP:0002418)3.35247183
29Molar tooth sign on MRI (HP:0002419)3.35247183
30Chronic sinusitis (HP:0011109)3.33937608
31Generalized aminoaciduria (HP:0002909)3.31851392
32Intrahepatic cholestasis (HP:0001406)3.21409493
33Hypoglycemic seizures (HP:0002173)3.20217160
34Hypobetalipoproteinemia (HP:0003563)3.18922027
35Abnormality of the intrinsic pathway (HP:0010989)3.18019670
36Ketoacidosis (HP:0001993)3.15610404
37Lactic acidosis (HP:0003128)3.09733465
38Prolonged partial thromboplastin time (HP:0003645)3.07777831
39Bronchitis (HP:0012387)3.06074576
40Lethargy (HP:0001254)3.05739265
41Lipid accumulation in hepatocytes (HP:0006561)3.04784829
42Hyperinsulinemic hypoglycemia (HP:0000825)3.04551550
43Ketosis (HP:0001946)3.02739048
44Abnormality of the nasal mucosa (HP:0000433)3.01154655
45Abnormality of fatty-acid metabolism (HP:0004359)2.99266081
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.98111098
47Increased hepatocellular lipid droplets (HP:0006565)2.96442597
48Renal Fanconi syndrome (HP:0001994)2.93575269
49Hyperglycinemia (HP:0002154)2.89140384
50Gout (HP:0001997)2.84920428
513-Methylglutaconic aciduria (HP:0003535)2.84805207
52Respiratory failure (HP:0002878)2.84796693
53Symptomatic seizures (HP:0011145)2.82467378
54Increased intramyocellular lipid droplets (HP:0012240)2.81780367
55Abnormality of glycolysis (HP:0004366)2.81709548
56Increased serum pyruvate (HP:0003542)2.81709548
57Recurrent sinusitis (HP:0011108)2.81345603
58Nephronophthisis (HP:0000090)2.80700248
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.78678099
60Glycosuria (HP:0003076)2.77159229
61Abnormality of urine glucose concentration (HP:0011016)2.77159229
62Increased serum lactate (HP:0002151)2.71842298
63Increased muscle lipid content (HP:0009058)2.71224273
64Conjugated hyperbilirubinemia (HP:0002908)2.69150098
65Fat malabsorption (HP:0002630)2.68615471
66Dicarboxylic aciduria (HP:0003215)2.64045911
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64045911
68Occipital encephalocele (HP:0002085)2.63722220
69Infertility (HP:0000789)2.62451926
70CNS demyelination (HP:0007305)2.61717151
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.59125095
72Exercise intolerance (HP:0003546)2.57029013
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54277535
74Neuroendocrine neoplasm (HP:0100634)2.52529517
75Cystic liver disease (HP:0006706)2.51790304
76Hyperglycinuria (HP:0003108)2.49297864
77Hypothermia (HP:0002045)2.47176769
78Xanthomatosis (HP:0000991)2.43371048
79Pheochromocytoma (HP:0002666)2.43216273
80Abnormality of serine family amino acid metabolism (HP:0010894)2.41579798
81Abnormality of glycine metabolism (HP:0010895)2.41579798
82Hyperammonemia (HP:0001987)2.41167520
83Abnormality of the common coagulation pathway (HP:0010990)2.39861075
84Congenital, generalized hypertrichosis (HP:0004540)2.38111189
85Leukodystrophy (HP:0002415)2.37513521
86Abnormal rod and cone electroretinograms (HP:0008323)2.33012920
87Steatorrhea (HP:0002570)2.32494492
88Macrocytic anemia (HP:0001972)2.31899364
89Vacuolated lymphocytes (HP:0001922)2.30880834
90Hyperphosphaturia (HP:0003109)2.30769439
91Abnormal number of erythroid precursors (HP:0012131)2.27909844
92Vomiting (HP:0002013)2.27316374
93Methylmalonic aciduria (HP:0012120)2.25142890
94Late onset (HP:0003584)2.25068256
95Spastic paraparesis (HP:0002313)2.22655615
96Recurrent otitis media (HP:0000403)2.22018246
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21552468
98Medial flaring of the eyebrow (HP:0010747)2.21246349
99Male pseudohermaphroditism (HP:0000037)2.21158196
100Optic disc pallor (HP:0000543)2.19545705
101Abnormality of serum amino acid levels (HP:0003112)2.19041282
102Abnormality of the renal medulla (HP:0100957)2.17485935
103Reticulocytopenia (HP:0001896)2.16684317
104Type I transferrin isoform profile (HP:0003642)2.15573610
105Hyperactive renin-angiotensin system (HP:0000841)2.15540479
106Sclerocornea (HP:0000647)2.15041803
107Abnormality of methionine metabolism (HP:0010901)2.13707378
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12356528
109Abnormal protein N-linked glycosylation (HP:0012347)2.12356528
110Abnormal protein glycosylation (HP:0012346)2.12356528
111Abnormal glycosylation (HP:0012345)2.12356528
112Oligomenorrhea (HP:0000876)2.11295295
113Metabolic acidosis (HP:0001942)2.10471657
114Furrowed tongue (HP:0000221)2.09400957
115Chronic otitis media (HP:0000389)2.06778549
116Opisthotonus (HP:0002179)2.04598388
117Deep venous thrombosis (HP:0002625)2.02487196
118Exertional dyspnea (HP:0002875)2.02432479
119Hyperglycemia (HP:0003074)2.01686908
120Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01650308
121Beaking of vertebral bodies (HP:0004568)2.00924426
122Abnormality of purine metabolism (HP:0004352)2.00719797
123Abnormality of renal resorption (HP:0011038)2.00358454
124Hyperbilirubinemia (HP:0002904)1.99691595
125Irritability (HP:0000737)1.98571124
126Brushfield spots (HP:0001088)1.98028329
127Abnormality of sulfur amino acid metabolism (HP:0004339)1.97474205
128Anencephaly (HP:0002323)1.97059157
129Palpitations (HP:0001962)1.96005459
130Decreased central vision (HP:0007663)1.93809548
131Male infertility (HP:0003251)1.92032960
132Abnormality of the pancreatic islet cells (HP:0006476)1.90850053
133Abnormality of endocrine pancreas physiology (HP:0012093)1.90850053
134Abnormality of cells of the erythroid lineage (HP:0012130)1.90817945
135Aplastic anemia (HP:0001915)1.90061929
136Emotional lability (HP:0000712)1.89021212
137Pancreatitis (HP:0001733)1.87701514
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.87555006
139Postaxial foot polydactyly (HP:0001830)1.84924595
140Chronic hepatic failure (HP:0100626)1.83690423
141Hyperlipoproteinemia (HP:0010980)1.83009833
142Dysautonomia (HP:0002459)1.82610958
143Abnormal pancreas size (HP:0012094)1.81759988
144Abnormal pupillary function (HP:0007686)1.81734255
145Asplenia (HP:0001746)1.81427917
146Hypolipoproteinemia (HP:0010981)1.81357304
147Congenital hepatic fibrosis (HP:0002612)1.81018991
148Oculomotor apraxia (HP:0000657)1.76149202
149Aplasia/Hypoplasia of the spleen (HP:0010451)1.75249220
150Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71093460
151Congenital stationary night blindness (HP:0007642)1.67460342
152Renal salt wasting (HP:0000127)1.67219685
153Aplasia/hypoplasia of the uterus (HP:0008684)1.65910893
154Congenital primary aphakia (HP:0007707)1.62487382
155Constricted visual fields (HP:0001133)1.61365811
156Respiratory difficulties (HP:0002880)1.60043302
157Tubulointerstitial nephritis (HP:0001970)1.59477477
158Abnormal biliary tract physiology (HP:0012439)1.56181694
159Bile duct proliferation (HP:0001408)1.56181694
160Recurrent bronchitis (HP:0002837)1.54143192
161Abolished electroretinogram (ERG) (HP:0000550)1.53799640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.82135675
2VRK24.57626446
3NME24.47285364
4INSRR3.16368120
5STK163.15359480
6ARAF2.96922854
7EIF2AK32.89567905
8NME12.86638740
9PIM22.46972344
10LIMK12.42814709
11TESK12.38359087
12ERN12.07245612
13BUB11.99644197
14EIF2AK11.99180155
15BRAF1.93234009
16IRAK31.85902022
17PASK1.80093022
18GRK11.75587054
19MAP3K31.70294434
20MAP3K121.65824987
21CAMKK21.63477637
22LRRK21.55369001
23TESK21.52955328
24ZAK1.49717016
25TSSK61.47332850
26MAP3K21.44554607
27TAOK31.37792064
28MYLK1.37630474
29PIK3CG1.32036533
30BCR1.28516592
31WNK41.25486654
32IRAK11.21741992
33AKT31.20965425
34MAPK151.19071494
35NUAK11.17540608
36FRK1.15754398
37ERBB31.15391408
38ABL21.15123647
39BMPR1B1.12031634
40MAP2K21.11180408
41GRK51.09703051
42BRSK21.07762998
43BMPR21.06473175
44KDR1.01745629
45TXK0.98393594
46CCNB10.96507868
47MST40.96256291
48CDK190.93504629
49PBK0.93147036
50VRK10.92884765
51TIE10.91197566
52TAF10.86927449
53MARK30.83251159
54TTK0.83245269
55ILK0.83113254
56PDK40.82937617
57PDK30.82937617
58FLT30.81911081
59PRKCI0.80429672
60PLK30.80423200
61TEC0.79560291
62MAP2K60.78885935
63TBK10.77390231
64PINK10.76597192
65OXSR10.75608964
66CSNK1G30.72285201
67WEE10.70977893
68DYRK20.68328236
69IRAK20.68141506
70PLK10.68120745
71CASK0.67788262
72FGFR40.65345326
73TGFBR10.65132887
74PRKCQ0.63060155
75MST1R0.62185561
76ADRBK20.60769371
77TRIM280.58420402
78ACVR1B0.57335872
79IRAK40.56984682
80MAP2K10.56379328
81CAMK2G0.55353621
82BRSK10.54988279
83PAK40.54906247
84PAK10.54355204
85SRPK10.53158254
86MUSK0.52997059
87PRKCE0.52925390
88MKNK10.52343826
89AURKA0.52240566
90PAK30.52235981
91KIT0.52083471
92SCYL20.51891054
93MAPKAPK30.51757606
94CDC70.51152556
95MAP3K110.50896157
96AURKB0.50083985
97MKNK20.47113117
98WNK30.46488828
99CSNK1G10.45875785
100PDK20.45861102
101CSNK2A10.45353511
102STK390.45158571
103CSNK2A20.44382966
104PRKCG0.43976621
105MAP4K20.42955569
106PTK2B0.42916669
107STK240.42764867
108CSNK1G20.42083177
109PLK40.41657938
110STK100.41453045
111ADRBK10.41019949
112IKBKB0.40978836
113MAP2K30.40956027
114ZAP700.40896432
115GRK60.40713376
116CDK80.39545539
117TLK10.38728047
118ITK0.38598123
119RPS6KA50.38434296
120MAP2K70.38224952
121LYN0.37919434
122NLK0.37133246
123DAPK30.36419458
124PRKCA0.36236482
125NEK10.36226997
126RPS6KB20.35241009
127CSK0.35135475
128CHEK20.34664352
129MAPKAPK50.34358597
130DAPK10.34283035
131EPHA20.34202430
132IKBKE0.33502064
133GRK70.32661881
134NTRK10.32143576
135OBSCN0.31592986
136RPS6KB10.31441446
137PRKCD0.30342346
138ERBB40.29035020
139PRKACA0.28841889
140MET0.27965811

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.31346106
2Oxidative phosphorylation_Homo sapiens_hsa001903.50217166
3Proteasome_Homo sapiens_hsa030503.36189905
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.89590819
5Parkinsons disease_Homo sapiens_hsa050122.88272892
6Sulfur metabolism_Homo sapiens_hsa009202.74430336
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.31447396
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.30668916
9Ribosome_Homo sapiens_hsa030102.27464260
10Folate biosynthesis_Homo sapiens_hsa007902.15565199
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12419781
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08735497
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06850815
14Alzheimers disease_Homo sapiens_hsa050102.04079243
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.02505430
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.99006433
17Huntingtons disease_Homo sapiens_hsa050161.80551524
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75382942
19Tryptophan metabolism_Homo sapiens_hsa003801.67158435
20Peroxisome_Homo sapiens_hsa041461.64915713
21Propanoate metabolism_Homo sapiens_hsa006401.61687915
22RNA polymerase_Homo sapiens_hsa030201.59214538
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55847377
24Pyruvate metabolism_Homo sapiens_hsa006201.54590099
25Fatty acid elongation_Homo sapiens_hsa000621.51054216
26Butanoate metabolism_Homo sapiens_hsa006501.50408190
27Asthma_Homo sapiens_hsa053101.50026507
28Vibrio cholerae infection_Homo sapiens_hsa051101.44805083
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43447300
30Phenylalanine metabolism_Homo sapiens_hsa003601.39962341
31Homologous recombination_Homo sapiens_hsa034401.39285313
32Fatty acid degradation_Homo sapiens_hsa000711.36851390
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.36650259
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36108728
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35556841
36Collecting duct acid secretion_Homo sapiens_hsa049661.32820567
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32142048
38Selenocompound metabolism_Homo sapiens_hsa004501.32123699
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.30029393
40Mismatch repair_Homo sapiens_hsa034301.26924572
41Steroid biosynthesis_Homo sapiens_hsa001001.23584220
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23254137
43Tyrosine metabolism_Homo sapiens_hsa003501.22456415
44Carbon metabolism_Homo sapiens_hsa012001.21660326
45Histidine metabolism_Homo sapiens_hsa003401.19948426
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19611487
47Allograft rejection_Homo sapiens_hsa053301.16842938
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.11978316
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.08632328
50Autoimmune thyroid disease_Homo sapiens_hsa053201.08555346
51Arginine biosynthesis_Homo sapiens_hsa002201.07470705
52Graft-versus-host disease_Homo sapiens_hsa053321.06155144
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05564550
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05017969
55Pyrimidine metabolism_Homo sapiens_hsa002401.04745320
56Sulfur relay system_Homo sapiens_hsa041221.03130207
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02752809
58Fructose and mannose metabolism_Homo sapiens_hsa000511.01426372
59Phototransduction_Homo sapiens_hsa047441.00850945
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00730916
61DNA replication_Homo sapiens_hsa030301.00676455
62Biosynthesis of amino acids_Homo sapiens_hsa012300.99393500
63Primary immunodeficiency_Homo sapiens_hsa053400.99011526
64Arginine and proline metabolism_Homo sapiens_hsa003300.99002423
65Fat digestion and absorption_Homo sapiens_hsa049750.98418447
66Vitamin B6 metabolism_Homo sapiens_hsa007500.97497808
67Glutathione metabolism_Homo sapiens_hsa004800.97431307
68Chemical carcinogenesis_Homo sapiens_hsa052040.95870257
69beta-Alanine metabolism_Homo sapiens_hsa004100.93254606
70Base excision repair_Homo sapiens_hsa034100.93157628
71Spliceosome_Homo sapiens_hsa030400.93001983
72Metabolic pathways_Homo sapiens_hsa011000.92589582
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92587339
74Caffeine metabolism_Homo sapiens_hsa002320.90881407
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90739320
76RNA degradation_Homo sapiens_hsa030180.90231562
77Basal transcription factors_Homo sapiens_hsa030220.89430515
78Fatty acid metabolism_Homo sapiens_hsa012120.88059571
79Galactose metabolism_Homo sapiens_hsa000520.81818647
80Regulation of autophagy_Homo sapiens_hsa041400.80231101
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78233345
82Antigen processing and presentation_Homo sapiens_hsa046120.72291521
83Pentose phosphate pathway_Homo sapiens_hsa000300.70472992
84Starch and sucrose metabolism_Homo sapiens_hsa005000.68761234
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68687460
86N-Glycan biosynthesis_Homo sapiens_hsa005100.68345855
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67298471
88Complement and coagulation cascades_Homo sapiens_hsa046100.67165733
89RNA transport_Homo sapiens_hsa030130.63215821
90Fanconi anemia pathway_Homo sapiens_hsa034600.62900906
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60825309
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58385164
93PPAR signaling pathway_Homo sapiens_hsa033200.57677355
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.56113904
95Retinol metabolism_Homo sapiens_hsa008300.56085654
96Cardiac muscle contraction_Homo sapiens_hsa042600.54863979
97Lysosome_Homo sapiens_hsa041420.53894226
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53844597
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52653722
100Purine metabolism_Homo sapiens_hsa002300.50875280
101Linoleic acid metabolism_Homo sapiens_hsa005910.48147404
102Rheumatoid arthritis_Homo sapiens_hsa053230.45653254
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45268424
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.42900711
105Phagosome_Homo sapiens_hsa041450.42184545
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41944703
107Other glycan degradation_Homo sapiens_hsa005110.39997008
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38958775
109Mineral absorption_Homo sapiens_hsa049780.38907240
110Nitrogen metabolism_Homo sapiens_hsa009100.38448705
111Hematopoietic cell lineage_Homo sapiens_hsa046400.38442229
112Arachidonic acid metabolism_Homo sapiens_hsa005900.36007358
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35637345
114Vitamin digestion and absorption_Homo sapiens_hsa049770.33649065
115Type I diabetes mellitus_Homo sapiens_hsa049400.33052130
116One carbon pool by folate_Homo sapiens_hsa006700.31193292
117Sphingolipid metabolism_Homo sapiens_hsa006000.31096169
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29682646
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29331860
120Synaptic vesicle cycle_Homo sapiens_hsa047210.28192509
121Non-homologous end-joining_Homo sapiens_hsa034500.28064888
122Legionellosis_Homo sapiens_hsa051340.25767822
123Prion diseases_Homo sapiens_hsa050200.25310026
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23748658
125Glycerolipid metabolism_Homo sapiens_hsa005610.22123293
126Ether lipid metabolism_Homo sapiens_hsa005650.22080219
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19965730
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19822059
129Nucleotide excision repair_Homo sapiens_hsa034200.19376781

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