UFD1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.35722866
2central nervous system myelination (GO:0022010)6.35722866
3fatty acid elongation (GO:0030497)5.57431068
4DNA replication checkpoint (GO:0000076)5.22495523
5protein neddylation (GO:0045116)5.10327312
6long-chain fatty acid biosynthetic process (GO:0042759)4.99897368
7chaperone-mediated protein transport (GO:0072321)4.34293986
8presynaptic membrane assembly (GO:0097105)4.24941635
9DNA strand elongation involved in DNA replication (GO:0006271)4.24191155
10neuron cell-cell adhesion (GO:0007158)4.18421897
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.14166954
12telomere maintenance via semi-conservative replication (GO:0032201)4.11386038
13response to redox state (GO:0051775)4.09427898
14DNA strand elongation (GO:0022616)4.09316046
15presynaptic membrane organization (GO:0097090)4.07240581
16positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.88367442
17positive regulation of ligase activity (GO:0051351)3.73978092
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.67385306
19cullin deneddylation (GO:0010388)3.65209683
20ribosomal small subunit biogenesis (GO:0042274)3.65168298
21pseudouridine synthesis (GO:0001522)3.64905365
22negative regulation of neurotransmitter transport (GO:0051589)3.63855667
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.62805177
24negative regulation of neurotransmitter secretion (GO:0046929)3.60763706
25nuclear pore complex assembly (GO:0051292)3.60578319
26ribosomal large subunit biogenesis (GO:0042273)3.56823077
27purine nucleobase biosynthetic process (GO:0009113)3.56799272
28telomere maintenance via recombination (GO:0000722)3.56654179
29rRNA modification (GO:0000154)3.55068986
30regulation of ubiquitin-protein transferase activity (GO:0051438)3.53819067
31DNA replication initiation (GO:0006270)3.53299951
32myelination (GO:0042552)3.53076923
33ATP synthesis coupled proton transport (GO:0015986)3.52624905
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52624905
35mitotic sister chromatid segregation (GO:0000070)3.51599036
36formation of translation preinitiation complex (GO:0001731)3.50613552
37limb bud formation (GO:0060174)3.50295916
38nucleobase biosynthetic process (GO:0046112)3.46880969
39maturation of SSU-rRNA (GO:0030490)3.46172732
40ensheathment of neurons (GO:0007272)3.44796495
41axon ensheathment (GO:0008366)3.44796495
42regulation of ligase activity (GO:0051340)3.43195806
43ribonucleoprotein complex biogenesis (GO:0022613)3.38436936
44oxidative phosphorylation (GO:0006119)3.37966162
45mitotic recombination (GO:0006312)3.37850309
46proteasome assembly (GO:0043248)3.33232646
47ribosome biogenesis (GO:0042254)3.32203185
48protein deneddylation (GO:0000338)3.31234341
49cholesterol biosynthetic process (GO:0006695)3.31230664
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28570377
51ribosome assembly (GO:0042255)3.26946621
52negative regulation of protein localization to cell surface (GO:2000009)3.25060692
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21941392
54regulation of cellular amino acid metabolic process (GO:0006521)3.21612336
55regulation of collateral sprouting (GO:0048670)3.21352420
56substantia nigra development (GO:0021762)3.20442385
57rRNA methylation (GO:0031167)3.20403165
58ribosomal small subunit assembly (GO:0000028)3.19312637
59regulation of mitochondrial translation (GO:0070129)3.19111641
60mannosylation (GO:0097502)3.19075411
61rRNA processing (GO:0006364)3.18260227
62mitotic nuclear envelope disassembly (GO:0007077)3.17436553
63nucleobase-containing small molecule interconversion (GO:0015949)3.16875434
64amino acid salvage (GO:0043102)3.16797237
65L-methionine salvage (GO:0071267)3.16797237
66L-methionine biosynthetic process (GO:0071265)3.16797237
67sister chromatid segregation (GO:0000819)3.16663930
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15509905
69kinetochore organization (GO:0051383)3.15323707
70transcription-coupled nucleotide-excision repair (GO:0006283)3.14667910
71CENP-A containing nucleosome assembly (GO:0034080)3.14377458
72transcription elongation from RNA polymerase III promoter (GO:0006385)3.13335387
73termination of RNA polymerase III transcription (GO:0006386)3.13335387
74nuclear pore organization (GO:0006999)3.12746764
75synapsis (GO:0007129)3.09797945
76DNA unwinding involved in DNA replication (GO:0006268)3.08988293
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08546600
78cell cycle G1/S phase transition (GO:0044843)3.07410136
79G1/S transition of mitotic cell cycle (GO:0000082)3.07410136
80rRNA metabolic process (GO:0016072)3.06513001
81tRNA aminoacylation for protein translation (GO:0006418)3.06018760
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.05977874
83chromatin remodeling at centromere (GO:0031055)3.05918251
84respiratory electron transport chain (GO:0022904)3.05827737
85tRNA aminoacylation (GO:0043039)3.05481748
86amino acid activation (GO:0043038)3.05481748
87folic acid-containing compound biosynthetic process (GO:0009396)3.03386203
88cellular component biogenesis (GO:0044085)3.00991798
89GPI anchor biosynthetic process (GO:0006506)3.00390155
90transferrin transport (GO:0033572)2.99434731
91electron transport chain (GO:0022900)2.99356263
92nucleotide transmembrane transport (GO:1901679)2.99255929
93glycerophospholipid catabolic process (GO:0046475)2.98585872
94neurotransmitter uptake (GO:0001504)2.98016932
95meiotic chromosome segregation (GO:0045132)2.97946601
96telomere maintenance via telomere lengthening (GO:0010833)2.97738449
97mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.96161810
98positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.96161810
99translation (GO:0006412)2.96156184
1007-methylguanosine mRNA capping (GO:0006370)2.95582496
101mitotic metaphase plate congression (GO:0007080)2.94677301
102pore complex assembly (GO:0046931)2.94607541
103kinetochore assembly (GO:0051382)2.93330923
104translational termination (GO:0006415)2.92200951
105ATP hydrolysis coupled proton transport (GO:0015991)2.91518120
106energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91518120
107DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.91375438
108microtubule polymerization or depolymerization (GO:0031109)2.91343493
109positive regulation of cell cycle arrest (GO:0071158)2.90848130
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90793976
111negative regulation of ligase activity (GO:0051352)2.90793976
112spliceosomal snRNP assembly (GO:0000387)2.90493225
113protein complex biogenesis (GO:0070271)2.88849916
114RNA capping (GO:0036260)2.88019490
1157-methylguanosine RNA capping (GO:0009452)2.88019490
116pteridine-containing compound biosynthetic process (GO:0042559)2.87820287
117sterol biosynthetic process (GO:0016126)2.87020991
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86874942
119IMP biosynthetic process (GO:0006188)2.86842200
120establishment of protein localization to mitochondrion (GO:0072655)2.86406959
121mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86334619
122mitochondrial respiratory chain complex I assembly (GO:0032981)2.86334619
123NADH dehydrogenase complex assembly (GO:0010257)2.86334619
124oligodendrocyte differentiation (GO:0048709)2.85812068
125viral transcription (GO:0019083)2.84974842
126DNA catabolic process, exonucleolytic (GO:0000738)2.84963723
127positive regulation of action potential (GO:0045760)2.84877147
128resolution of meiotic recombination intermediates (GO:0000712)2.84521940
129membrane disassembly (GO:0030397)2.83892908
130nuclear envelope disassembly (GO:0051081)2.83892908
131SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82645048
132GPI anchor metabolic process (GO:0006505)2.81659107
133keratinocyte development (GO:0003334)2.81638443
134preassembly of GPI anchor in ER membrane (GO:0016254)2.81563999
135isoprenoid biosynthetic process (GO:0008299)2.79472088
136transmission of nerve impulse (GO:0019226)2.79371189
137positive regulation of protein homodimerization activity (GO:0090073)2.78157914
138establishment of protein localization to mitochondrial membrane (GO:0090151)2.75893672
139establishment of mitochondrion localization (GO:0051654)2.75794683
140DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75422555
141ferric iron transport (GO:0015682)2.74886955
142trivalent inorganic cation transport (GO:0072512)2.74886955
143positive regulation of synapse assembly (GO:0051965)2.74172973
144neuronal action potential propagation (GO:0019227)2.71827622
145regulation of cellular amine metabolic process (GO:0033238)2.70659829
146signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69711744
147signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69711744
148signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69711744
149intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68015518
150signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68015518
151regulation of feeding behavior (GO:0060259)2.65322009
152startle response (GO:0001964)2.63954331
153signal transduction involved in cell cycle checkpoint (GO:0072395)2.63777981
154regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.63169554
155mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.61879160
156signal transduction involved in DNA integrity checkpoint (GO:0072401)2.58641872
157signal transduction involved in DNA damage checkpoint (GO:0072422)2.58641872
158protein targeting to mitochondrion (GO:0006626)2.58143667
159positive regulation of mitochondrial fission (GO:0090141)2.56278561
160peptidyl-histidine modification (GO:0018202)2.55358109
161regulation of glutamate secretion (GO:0014048)2.53752656
162anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.51944968
163viral protein processing (GO:0019082)2.51300674
164regulation of rhodopsin mediated signaling pathway (GO:0022400)2.51245495
165antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.51059739
166regulation of dopamine metabolic process (GO:0042053)2.49640945
167regulation of catecholamine metabolic process (GO:0042069)2.49640945
168cerebral cortex radially oriented cell migration (GO:0021799)2.48255546
169synaptic vesicle exocytosis (GO:0016079)2.47991260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.90478037
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.00350360
3GBX2_23144817_ChIP-Seq_PC3_Human3.67994003
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.60606474
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36604542
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.28141012
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97349533
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97027099
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.95307817
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87435491
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80731468
12TAF15_26573619_Chip-Seq_HEK293_Human2.70120040
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62476414
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59299183
15* DCP1A_22483619_ChIP-Seq_HELA_Human2.57256745
16EZH2_22144423_ChIP-Seq_EOC_Human2.54375449
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.53439578
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48703596
19VDR_23849224_ChIP-Seq_CD4+_Human2.42254740
20XRN2_22483619_ChIP-Seq_HELA_Human2.37874541
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.37231546
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36425037
23ELK1_19687146_ChIP-ChIP_HELA_Human2.34354169
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29878863
25* FOXP3_21729870_ChIP-Seq_TREG_Human2.25370378
26VDR_22108803_ChIP-Seq_LS180_Human2.21898436
27* GABP_19822575_ChIP-Seq_HepG2_Human2.15899467
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15485092
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11885475
30* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07543904
31BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04217618
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02742666
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00802497
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00453105
35* EST1_17652178_ChIP-ChIP_JURKAT_Human1.99440857
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98399022
37* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95369956
38* TTF2_22483619_ChIP-Seq_HELA_Human1.95301038
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.94412297
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92869100
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.92259073
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91770103
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89214999
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85557138
45ER_23166858_ChIP-Seq_MCF-7_Human1.84133772
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.82943771
47KDM5A_27292631_Chip-Seq_BREAST_Human1.82583293
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80226743
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78394518
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78390237
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77476401
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76137577
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75767881
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.75148172
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73173867
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.70101393
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68656816
58FUS_26573619_Chip-Seq_HEK293_Human1.67353891
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65546886
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64331963
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62015188
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.61784722
63P300_19829295_ChIP-Seq_ESCs_Human1.61046741
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53775038
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52788536
66* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52702996
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52261301
68CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52057329
69* ETS1_20019798_ChIP-Seq_JURKAT_Human1.51201694
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49638374
71REST_21632747_ChIP-Seq_MESCs_Mouse1.48980784
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47628420
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46101090
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44673437
75* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44572872
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43893955
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42841578
78* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41128986
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37529819
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37187841
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36422999
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36219901
83AR_21909140_ChIP-Seq_LNCAP_Human1.36068868
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35737238
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.34892827
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34637786
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34390069
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32682389
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.32569573
90TFEB_21752829_ChIP-Seq_HELA_Human1.31418778
91RNF2_27304074_Chip-Seq_NSC_Mouse1.30486532
92CIITA_25753668_ChIP-Seq_RAJI_Human1.29247244
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.28835443
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28770330
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27681726
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27455164
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26848998
98* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26602879
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25464499
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.24114188
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23945716
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22479729
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22114817
104EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22055856
105RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22055856
106SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21760311
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.21165969
108* NCOR1_26117541_ChIP-Seq_K562_Human1.20958172
109* YY1_21170310_ChIP-Seq_MESCs_Mouse1.20048723
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19516227
111REST_18959480_ChIP-ChIP_MESCs_Mouse1.19317950
112SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18564418
113EWS_26573619_Chip-Seq_HEK293_Human1.18543497
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18119233
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18107720
116TAL1_26923725_Chip-Seq_HPCs_Mouse1.17678656
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17383555
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16479572
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15844891
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15773209
121SMAD4_21799915_ChIP-Seq_A2780_Human1.15767188
122EGR1_19374776_ChIP-ChIP_THP-1_Human1.15520449
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14652576
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.13905585
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13862807
126MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12667334
127MYC_18940864_ChIP-ChIP_HL60_Human1.12116399
128HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11335050
129* SOX9_26525672_Chip-Seq_HEART_Mouse1.10981583
130STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10939876
131HTT_18923047_ChIP-ChIP_STHdh_Human1.09594550
132AR_21572438_ChIP-Seq_LNCaP_Human1.09063460
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.08568850
134* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08293724
135P300_18555785_Chip-Seq_ESCs_Mouse1.08139640
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07861246
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07647207
138PIAS1_25552417_ChIP-Seq_VCAP_Human1.06790804
139P53_22387025_ChIP-Seq_ESCs_Mouse1.06032976
140STAT3_18555785_Chip-Seq_ESCs_Mouse1.05758826
141* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05475617
142RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03833063
143IRF1_19129219_ChIP-ChIP_H3396_Human1.03438678
144* JUN_21703547_ChIP-Seq_K562_Human1.02709676
145GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01294916
146* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01111503
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01099123
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00960991
149MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00832740
150RNF2_27304074_Chip-Seq_ESCs_Mouse1.00436936
151SOX2_18555785_Chip-Seq_ESCs_Mouse0.99701559
152ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98352873
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98255287
154PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98237462
155PRDM14_20953172_ChIP-Seq_ESCs_Human0.97949253
156GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97724681
157KLF4_18555785_Chip-Seq_ESCs_Mouse0.97106009
158SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96972182
159SMAD_19615063_ChIP-ChIP_OVARY_Human0.96871436
160NFE2_27457419_Chip-Seq_LIVER_Mouse0.96581542
161CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96132273
162KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96038915
163ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94907695
164ELK1_22589737_ChIP-Seq_MCF10A_Human0.93320256
165* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92834072
166HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92531354
167TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88658480
168* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85513503
169POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83528347
170CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79445175
171* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79339511
172SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78935792
173TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77972148
174PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.74972595
175ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.73558912
176TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.73458546
177CHD1_26751641_Chip-Seq_LNCaP_Human0.71357992
178TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70111951
179FOXP1_21924763_ChIP-Seq_HESCs_Human0.68556485
180SPI1_23547873_ChIP-Seq_NB4_Human0.68199624
181NOTCH1_21737748_ChIP-Seq_TLL_Human0.66965330
182ZNF263_19887448_ChIP-Seq_K562_Human0.65251917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.39948239
2MP0008058_abnormal_DNA_repair4.35250013
3MP0010094_abnormal_chromosome_stability4.34451431
4MP0003111_abnormal_nucleus_morphology4.25453637
5MP0004957_abnormal_blastocyst_morpholog4.23630478
6MP0003880_abnormal_central_pattern4.20840782
7MP0003806_abnormal_nucleotide_metabolis3.53505267
8MP0003077_abnormal_cell_cycle3.25511913
9MP0003786_premature_aging3.25174790
10MP0001529_abnormal_vocalization3.19294776
11MP0009697_abnormal_copulation3.06523838
12MP0008007_abnormal_cellular_replicative3.02822013
13MP0008932_abnormal_embryonic_tissue2.90030309
14MP0008057_abnormal_DNA_replication2.80710662
15MP0001905_abnormal_dopamine_level2.79316058
16MP0006036_abnormal_mitochondrial_physio2.61829167
17MP0003186_abnormal_redox_activity2.59335970
18MP0004270_analgesia2.55168756
19MP0002064_seizures2.48222462
20MP0009046_muscle_twitch2.46339036
21MP0002272_abnormal_nervous_system2.44366893
22MP0000920_abnormal_myelination2.43420333
23MP0002734_abnormal_mechanical_nocicepti2.22358360
24MP0009745_abnormal_behavioral_response2.20685559
25MP0004142_abnormal_muscle_tone2.19866370
26MP0008995_early_reproductive_senescence2.18767303
27MP0003635_abnormal_synaptic_transmissio2.09859402
28MP0002822_catalepsy2.09763489
29MP0001968_abnormal_touch/_nociception2.09020049
30MP0001188_hyperpigmentation2.04447536
31MP0001986_abnormal_taste_sensitivity2.00873355
32MP0002736_abnormal_nociception_after1.99435716
33MP0004859_abnormal_synaptic_plasticity1.97995275
34MP0006276_abnormal_autonomic_nervous1.95647773
35MP0002572_abnormal_emotion/affect_behav1.95366861
36MP0001486_abnormal_startle_reflex1.92794597
37MP0002735_abnormal_chemical_nociception1.92550519
38MP0003950_abnormal_plasma_membrane1.91261356
39MP0005423_abnormal_somatic_nervous1.90701621
40MP0005171_absent_coat_pigmentation1.89755818
41MP0008260_abnormal_autophagy1.85903874
42MP0001440_abnormal_grooming_behavior1.85771146
43MP0005646_abnormal_pituitary_gland1.84893902
44MP0002063_abnormal_learning/memory/cond1.83074481
45MP0000358_abnormal_cell_content/1.77744357
46MP0000778_abnormal_nervous_system1.73702753
47MP0005645_abnormal_hypothalamus_physiol1.73699892
48MP0001501_abnormal_sleep_pattern1.72471335
49MP0002067_abnormal_sensory_capabilities1.71958929
50MP0004742_abnormal_vestibular_system1.71717946
51MP0003136_yellow_coat_color1.70182000
52MP0005409_darkened_coat_color1.68396839
53MP0000350_abnormal_cell_proliferation1.68237966
54MP0001730_embryonic_growth_arrest1.67603864
55MP0003329_amyloid_beta_deposits1.66052397
56MP0000678_abnormal_parathyroid_gland1.64585332
57MP0003656_abnormal_erythrocyte_physiolo1.62755554
58MP0005551_abnormal_eye_electrophysiolog1.61603646
59MP0001970_abnormal_pain_threshold1.58313895
60MP0001984_abnormal_olfaction1.57721381
61MP0005083_abnormal_biliary_tract1.57006718
62MP0000313_abnormal_cell_death1.55047524
63MP0002132_abnormal_respiratory_system1.53104965
64MP0001697_abnormal_embryo_size1.52154076
65MP0005386_behavior/neurological_phenoty1.51856973
66MP0004924_abnormal_behavior1.51856973
67MP0005408_hypopigmentation1.49042184
68MP0005410_abnormal_fertilization1.48110899
69MP0010386_abnormal_urinary_bladder1.46791755
70MP0002184_abnormal_innervation1.45903585
71MP0010307_abnormal_tumor_latency1.45640877
72MP0002876_abnormal_thyroid_physiology1.44935538
73MP0002210_abnormal_sex_determination1.39198515
74MP0002229_neurodegeneration1.35307257
75MP0002733_abnormal_thermal_nociception1.32260419
76MP0002080_prenatal_lethality1.31586647
77MP0003634_abnormal_glial_cell1.31160201
78MP0001929_abnormal_gametogenesis1.30846434
79MP0008569_lethality_at_weaning1.30621369
80MP0001764_abnormal_homeostasis1.30415006
81MP0004233_abnormal_muscle_weight1.28618440
82MP0004147_increased_porphyrin_level1.26308659
83MP0001542_abnormal_bone_strength1.26275385
84MP0001672_abnormal_embryogenesis/_devel1.25826508
85MP0005380_embryogenesis_phenotype1.25826508
86MP0002163_abnormal_gland_morphology1.25258883
87MP0002019_abnormal_tumor_incidence1.24915454
88MP0002882_abnormal_neuron_morphology1.23071362
89MP0004134_abnormal_chest_morphology1.22394808
90MP0005379_endocrine/exocrine_gland_phen1.21833671
91MP0002102_abnormal_ear_morphology1.21331943
92MP0009333_abnormal_splenocyte_physiolog1.21015219
93MP0003690_abnormal_glial_cell1.20873384
94MP0004381_abnormal_hair_follicle1.19533578
95MP0001485_abnormal_pinna_reflex1.17602344
96MP0002066_abnormal_motor_capabilities/c1.16145037
97MP0000955_abnormal_spinal_cord1.16071501
98MP0002751_abnormal_autonomic_nervous1.15833491
99MP0006292_abnormal_olfactory_placode1.15772909
100MP0003718_maternal_effect1.11998305
101MP0003984_embryonic_growth_retardation1.09619787
102MP0002752_abnormal_somatic_nervous1.09327528
103MP0003938_abnormal_ear_development1.09198598
104MP0006072_abnormal_retinal_apoptosis1.08466273
105MP0004145_abnormal_muscle_electrophysio1.07392620
106MP0008877_abnormal_DNA_methylation1.06635982
107MP0002557_abnormal_social/conspecific_i1.06064417
108MP0003632_abnormal_nervous_system1.05738121
109MP0001963_abnormal_hearing_physiology1.05510667
110MP0002088_abnormal_embryonic_growth/wei1.05079959
111MP0001661_extended_life_span1.04820891
112MP0001145_abnormal_male_reproductive1.03713574
113MP0005636_abnormal_mineral_homeostasis1.00864118
114MP0000653_abnormal_sex_gland0.99684921
115MP0000372_irregular_coat_pigmentation0.99620200
116MP0000703_abnormal_thymus_morphology0.99603912
117MP0001853_heart_inflammation0.99568605
118MP0002160_abnormal_reproductive_system0.96431404
119MP0001177_atelectasis0.95012364
120MP0002086_abnormal_extraembryonic_tissu0.94372087
121MP0000647_abnormal_sebaceous_gland0.93785089
122MP0002638_abnormal_pupillary_reflex0.92421051
123MP0003787_abnormal_imprinting0.91712321
124MP0002095_abnormal_skin_pigmentation0.91676572
125MP0001873_stomach_inflammation0.90003576
126MP0000631_abnormal_neuroendocrine_gland0.89868972
127MP0004043_abnormal_pH_regulation0.89132769
128MP0000013_abnormal_adipose_tissue0.87723629
129MP0005332_abnormal_amino_acid0.87262190
130MP0005451_abnormal_body_composition0.86789002
131MP0002938_white_spotting0.86710218
132MP0000026_abnormal_inner_ear0.86466804
133MP0000566_synostosis0.86434724
134MP0002085_abnormal_embryonic_tissue0.86430359
135MP0001881_abnormal_mammary_gland0.86413082
136MP0003631_nervous_system_phenotype0.86302568
137MP0005397_hematopoietic_system_phenotyp0.86107767
138MP0001545_abnormal_hematopoietic_system0.86107767
139MP0005253_abnormal_eye_physiology0.85759741
140MP0000015_abnormal_ear_pigmentation0.85361446
141MP0008875_abnormal_xenobiotic_pharmacok0.84916629
142MP0003698_abnormal_male_reproductive0.84314434
143MP0002396_abnormal_hematopoietic_system0.83722663
144MP0004885_abnormal_endolymph0.82536549
145MP0003122_maternal_imprinting0.81701272
146MP0009780_abnormal_chondrocyte_physiolo0.80469726
147MP0004811_abnormal_neuron_physiology0.78374741
148MP0002152_abnormal_brain_morphology0.77161236
149MP0002722_abnormal_immune_system0.76940971
150MP0001502_abnormal_circadian_rhythm0.76596910
151MP0002084_abnormal_developmental_patter0.76518280
152MP0006035_abnormal_mitochondrial_morpho0.75648815
153MP0005395_other_phenotype0.75493159
154MP0001119_abnormal_female_reproductive0.75020080
155MP0005266_abnormal_metabolism0.73316436
156MP0002837_dystrophic_cardiac_calcinosis0.71826955
157MP0005464_abnormal_platelet_physiology0.71257135
158MP0005384_cellular_phenotype0.71017067
159MP0000762_abnormal_tongue_morphology0.70703249
160MP0000609_abnormal_liver_physiology0.70439494
161MP0001727_abnormal_embryo_implantation0.70379503
162MP0001346_abnormal_lacrimal_gland0.69627309
163MP0002398_abnormal_bone_marrow0.68113999
164MP0005501_abnormal_skin_physiology0.68047122
165MP0000462_abnormal_digestive_system0.67584756
166MP0005174_abnormal_tail_pigmentation0.67412999
167MP0000689_abnormal_spleen_morphology0.66758888
168MP0003646_muscle_fatigue0.65810041
169MP0004808_abnormal_hematopoietic_stem0.65383770
170MP0009250_abnormal_appendicular_skeleto0.64342722
171MP0003699_abnormal_female_reproductive0.63905317
172MP0005389_reproductive_system_phenotype0.63095029
173MP0003941_abnormal_skin_development0.62792064
174MP0000371_diluted_coat_color0.62310858
175MP0002161_abnormal_fertility/fecundity0.61695545
176MP0002877_abnormal_melanocyte_morpholog0.61636397
177MP0002429_abnormal_blood_cell0.60515425
178MP0000598_abnormal_liver_morphology0.59179054
179MP0002970_abnormal_white_adipose0.58092033
180MP0005058_abnormal_lysosome_morphology0.56617847
181MP0009840_abnormal_foam_cell0.55151509
182MP0003763_abnormal_thymus_physiology0.54141358
183MP0001919_abnormal_reproductive_system0.52854436
184MP0003959_abnormal_lean_body0.52277085
185MP0005319_abnormal_enzyme/_coenzyme0.50828114

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.19782508
2Abnormality of glycolysis (HP:0004366)4.14221234
3Increased serum pyruvate (HP:0003542)4.14221234
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99534068
5Cholecystitis (HP:0001082)3.96073888
6Abnormal gallbladder physiology (HP:0012438)3.96073888
7Acute necrotizing encephalopathy (HP:0006965)3.93435399
8Chromsome breakage (HP:0040012)3.93270730
9Cerebral hypomyelination (HP:0006808)3.83969716
10Parakeratosis (HP:0001036)3.59933792
11Reticulocytopenia (HP:0001896)3.54222408
12Abnormal mitochondria in muscle tissue (HP:0008316)3.44269408
13Mitochondrial inheritance (HP:0001427)3.38936044
14Cerebral edema (HP:0002181)3.25435476
15Abnormal number of erythroid precursors (HP:0012131)3.22170672
16Progressive macrocephaly (HP:0004481)3.18497031
17Abnormality of cells of the erythroid lineage (HP:0012130)3.16382175
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.12421205
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.12421205
203-Methylglutaconic aciduria (HP:0003535)3.05260619
21Pheochromocytoma (HP:0002666)3.02345149
22Focal motor seizures (HP:0011153)3.01032040
23Degeneration of the lateral corticospinal tracts (HP:0002314)2.96839746
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.96839746
25Type I transferrin isoform profile (HP:0003642)2.96096722
26* Truncus arteriosus (HP:0001660)2.95930352
27Ileus (HP:0002595)2.95680947
28Congenital ichthyosiform erythroderma (HP:0007431)2.93602100
29Abnormality of the preputium (HP:0100587)2.93476675
30Neuroendocrine neoplasm (HP:0100634)2.92451267
31Epileptic encephalopathy (HP:0200134)2.89856602
32Sensory axonal neuropathy (HP:0003390)2.89154938
33Increased CSF lactate (HP:0002490)2.87937080
34Atonic seizures (HP:0010819)2.87851536
35Hepatocellular necrosis (HP:0001404)2.86150422
36Acute encephalopathy (HP:0006846)2.83296554
37Hyperventilation (HP:0002883)2.78657600
38Pallor (HP:0000980)2.77806129
39Increased intramyocellular lipid droplets (HP:0012240)2.76507021
40Medial flaring of the eyebrow (HP:0010747)2.75806309
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.71774871
42Abnormality of homocysteine metabolism (HP:0010919)2.68367233
43Homocystinuria (HP:0002156)2.68367233
44Abnormality of reticulocytes (HP:0004312)2.66501974
45Leukodystrophy (HP:0002415)2.64016539
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.59017723
47Macrocytic anemia (HP:0001972)2.58746409
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51373657
49Abnormal protein N-linked glycosylation (HP:0012347)2.51373657
50Abnormal protein glycosylation (HP:0012346)2.51373657
51Abnormal glycosylation (HP:0012345)2.51373657
52Meckel diverticulum (HP:0002245)2.51074996
53Myelodysplasia (HP:0002863)2.47431144
54Retinal dysplasia (HP:0007973)2.46198592
55Degeneration of anterior horn cells (HP:0002398)2.45813497
56Abnormality of the anterior horn cell (HP:0006802)2.45813497
57Hypoplasia of the capital femoral epiphysis (HP:0003090)2.44238090
58Pancytopenia (HP:0001876)2.44215777
59Abnormal hemoglobin (HP:0011902)2.43851987
60Aplastic anemia (HP:0001915)2.43669181
61Upper limb muscle weakness (HP:0003484)2.43369615
62Respiratory difficulties (HP:0002880)2.43337351
63Microvesicular hepatic steatosis (HP:0001414)2.42972054
64Gait imbalance (HP:0002141)2.41527443
65CNS hypomyelination (HP:0003429)2.39856700
66Abnormality of chromosome stability (HP:0003220)2.39283351
67Abnormality of the ileum (HP:0001549)2.37434093
68Renal Fanconi syndrome (HP:0001994)2.36008915
69Tinnitus (HP:0000360)2.35486194
70Absent epiphyses (HP:0010577)2.34938689
71Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.34938689
72Abnormal hair whorl (HP:0010721)2.33207702
73Increased muscle lipid content (HP:0009058)2.33029204
74Small intestinal stenosis (HP:0012848)2.31009346
75Duodenal stenosis (HP:0100867)2.31009346
76Optic disc pallor (HP:0000543)2.28375463
77Vaginal atresia (HP:0000148)2.28112191
78Hepatic necrosis (HP:0002605)2.27885039
79Congenital primary aphakia (HP:0007707)2.27785193
80Genital tract atresia (HP:0001827)2.27399181
81Nephrogenic diabetes insipidus (HP:0009806)2.26735936
82Abnormality of methionine metabolism (HP:0010901)2.26269290
83Reticulocytosis (HP:0001923)2.24950189
84Absent/shortened dynein arms (HP:0200106)2.23205662
85Dynein arm defect of respiratory motile cilia (HP:0012255)2.23205662
86Abnormality of DNA repair (HP:0003254)2.22084784
87Autoamputation (HP:0001218)2.20103800
88Hypothermia (HP:0002045)2.19992539
89Neurofibrillary tangles (HP:0002185)2.19642174
90Increased hepatocellular lipid droplets (HP:0006565)2.18871789
91Absent thumb (HP:0009777)2.18776493
92Duplicated collecting system (HP:0000081)2.15108170
93Adrenal hypoplasia (HP:0000835)2.12813634
94Broad-based gait (HP:0002136)2.10089670
95Split foot (HP:0001839)2.10035801
96Redundant skin (HP:0001582)2.09497134
97Conical tooth (HP:0000698)2.09209087
98Abnormality of sulfur amino acid metabolism (HP:0004339)2.08428559
99Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07954741
100Poor head control (HP:0002421)2.07668995
101Squamous cell carcinoma (HP:0002860)2.07387418
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06639378
103Abnormality of alanine metabolism (HP:0010916)2.06639378
104Hyperalaninemia (HP:0003348)2.06639378
105Oral leukoplakia (HP:0002745)2.06183195
106Thickened helices (HP:0000391)2.05995342
107Lethargy (HP:0001254)2.04748545
108Hypoplastic pelvis (HP:0008839)2.02640202
109Ankyloglossia (HP:0010296)2.02334830
110Septo-optic dysplasia (HP:0100842)2.01711723
111Delusions (HP:0000746)2.01398069
112Irregular epiphyses (HP:0010582)2.00426022
113* Hyperthyroidism (HP:0000836)2.00078561
114Exertional dyspnea (HP:0002875)1.99895837
115Respiratory failure (HP:0002878)1.99307354
116Abnormality of the corticospinal tract (HP:0002492)1.97983880
117Akinesia (HP:0002304)1.97928823
118Postnatal microcephaly (HP:0005484)1.96814454
119Abnormality of the pons (HP:0007361)1.96363127
120Poor speech (HP:0002465)1.95530964
121Febrile seizures (HP:0002373)1.95270475
122Cholelithiasis (HP:0001081)1.95147333
123Breast hypoplasia (HP:0003187)1.94102721
124CNS demyelination (HP:0007305)1.93801421
125Birth length less than 3rd percentile (HP:0003561)1.93404980
126Rough bone trabeculation (HP:0100670)1.93049594
127Progressive muscle weakness (HP:0003323)1.92892231
128Horseshoe kidney (HP:0000085)1.92417326
129Alacrima (HP:0000522)1.91978805
130Limb dystonia (HP:0002451)1.91270229
131Petechiae (HP:0000967)1.90601370
132Abnormality of the renal collecting system (HP:0004742)1.89721478
133Entropion (HP:0000621)1.88335967
134Generalized aminoaciduria (HP:0002909)1.88289880
135Hypoplasia of the pons (HP:0012110)1.87389037
136Myokymia (HP:0002411)1.86411599
137Poor suck (HP:0002033)1.85983347
138Abnormality of the septum pellucidum (HP:0007375)1.85826865
139Abnormality of cochlea (HP:0000375)1.85734603
140Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85493636
141Submucous cleft hard palate (HP:0000176)1.85316573
142Nausea (HP:0002018)1.84894674
143Absent septum pellucidum (HP:0001331)1.84626759
144Hypokinesia (HP:0002375)1.84612908
145Increased serum lactate (HP:0002151)1.83308593
146Poikiloderma (HP:0001029)1.83228091
147X-linked dominant inheritance (HP:0001423)1.81248515
148Abnormal respiratory epithelium morphology (HP:0012253)1.80318371
149Abnormal respiratory motile cilium morphology (HP:0005938)1.80318371
150Aplasia/Hypoplasia of the tibia (HP:0005772)1.78930032
151Short tibia (HP:0005736)1.78758568
152Lipid accumulation in hepatocytes (HP:0006561)1.78413649
153Dialeptic seizures (HP:0011146)1.78408663
154Spastic paraparesis (HP:0002313)1.76985956
155Abnormal ciliary motility (HP:0012262)1.76976622
156Spastic gait (HP:0002064)1.76901409
157Fetal akinesia sequence (HP:0001989)1.76795922
158Aplasia/hypoplasia of the uterus (HP:0008684)1.74217433
159Lactic acidosis (HP:0003128)1.73536785
160Brittle hair (HP:0002299)1.71788122
161Pancreatic fibrosis (HP:0100732)1.70684516
162Decreased lacrimation (HP:0000633)1.70322830
163Esotropia (HP:0000565)1.68813442
164Fibular aplasia (HP:0002990)1.68543761
165Exercise intolerance (HP:0003546)1.68096903
166Lissencephaly (HP:0001339)1.66953226
167Peripheral hypomyelination (HP:0007182)1.65380581
168Concave nail (HP:0001598)1.65320053
169Poor coordination (HP:0002370)1.64169594
170Abnormality of the umbilical cord (HP:0010881)1.63033398
171Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.62523573
172Type II lissencephaly (HP:0007260)1.62230771
173Abnormality of renal resorption (HP:0011038)1.61910544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.91516215
2STK163.39692518
3CDC73.31944290
4PRPF4B3.09969415
5NME23.01229638
6STK392.99310506
7OXSR12.93295370
8TTK2.91218417
9BCR2.43295215
10NEK12.35706875
11AKT32.35475763
12BUB12.25431749
13CLK12.16974739
14VRK22.01102539
15CDK191.96742244
16MST41.94053649
17BRSK21.93578084
18NME11.79862785
19TNIK1.78092961
20MARK11.77469033
21PNCK1.76643901
22NEK61.71180603
23EPHA41.68844684
24MAP3K121.63195029
25TSSK61.62965207
26BMPR1B1.62956810
27PBK1.61373886
28PLK21.45030312
29MAP2K71.44401340
30DYRK21.42716802
31PLK11.42417229
32IRAK31.42232197
33BRSK11.40272635
34ARAF1.40230083
35CHEK21.37017930
36CAMK2B1.36573342
37MAP3K21.31578817
38ATR1.30187334
39NTRK31.28774726
40EIF2AK11.27524994
41RAF11.22812081
42RIPK41.21917368
43LIMK11.21836651
44PKN11.21592526
45KSR21.17622930
46RPS6KB21.16265961
47CCNB11.13517572
48MAPK131.12939730
49UHMK11.11804464
50TLK11.10881828
51SGK2231.08374856
52SGK4941.08374856
53BRAF1.07826395
54MAPKAPK51.07023098
55AURKB1.06205390
56SRPK11.03295954
57MAP4K21.01690158
58CHEK11.01124358
59WNK41.00730468
60STK41.00266673
61PDK30.99169596
62PDK40.99169596
63CAMK2D0.97048511
64FRK0.96444501
65MAP3K80.95742211
66CSNK1G30.93909232
67MAP3K40.91583985
68EIF2AK30.91511356
69ADRBK20.90934936
70SCYL20.90759134
71MET0.90406220
72MKNK10.89702617
73PRKCE0.89535082
74VRK10.84342433
75PAK10.84260265
76WNK30.82331784
77CAMK2A0.81249017
78PDK20.80807397
79PLK30.80677660
80CAMK2G0.80654450
81CDK80.79963620
82CDK140.79887767
83PAK40.79827749
84AURKA0.79630317
85PRKCG0.79575064
86ROCK20.79456267
87CSNK1A1L0.73862740
88DYRK1A0.72298387
89YES10.71923603
90NEK20.71589830
91MKNK20.70874098
92PLK40.70849306
93MYLK0.70846073
94GRK70.70784292
95CDK70.70505539
96CDK180.70041208
97ATM0.69839375
98BMPR20.69758941
99GRK50.69006506
100ZAK0.68731220
101ILK0.68580516
102CDK30.68213657
103STK30.67154800
104CDK150.65981429
105KSR10.65917597
106STK100.63894545
107IRAK20.62907663
108CSNK2A10.62707487
109BMX0.62673122
110CDK50.61843508
111CSNK2A20.61056402
112BCKDK0.60326249
113CSNK1G20.60169697
114ALK0.60163913
115WNK10.59986689
116FGR0.59350804
117PINK10.56870859
118CDK11A0.56529440
119MAPKAPK30.56410081
120TEC0.55281711
121CDK10.54356716
122CSNK1G10.54353379
123NTRK20.53356629
124MINK10.53125007
125TXK0.52572241
126NUAK10.50605165
127MUSK0.49926642
128EIF2AK20.49184780
129ADRBK10.47871368
130MARK30.47573826
131CDK20.45910319
132CSNK1A10.44807397
133PIK3CG0.44388814
134LRRK20.43009326
135GRK10.41621208
136PRKACA0.41595489
137MAP2K10.41434212
138FGFR20.41307497
139TNK20.41175726
140SIK30.40664872
141TESK20.40456293
142PRKCI0.39296451
143NTRK10.39213321
144RPS6KA50.39022196
145IRAK10.38945605
146WEE10.38669613
147PAK30.38316422
148TRIM280.36225234
149PIM20.35521480
150PRKCQ0.35404695
151PRKG10.35269464
152PIM10.34318617
153CSNK1E0.34206738
154DAPK10.33918312
155MAP3K30.31233389
156CDK90.30966226
157ABL20.30120279
158IKBKB0.28547062
159CDK40.25321620
160CDK120.25194896
161INSRR0.24175774
162MAPK110.21417401
163FLT30.18870593

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.19106895
2DNA replication_Homo sapiens_hsa030303.87585230
3Oxidative phosphorylation_Homo sapiens_hsa001903.86721201
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.81029176
5Mismatch repair_Homo sapiens_hsa034303.61641118
6Protein export_Homo sapiens_hsa030603.00995660
7Collecting duct acid secretion_Homo sapiens_hsa049662.90737052
8Parkinsons disease_Homo sapiens_hsa050122.86378629
9Fatty acid elongation_Homo sapiens_hsa000622.83846762
10One carbon pool by folate_Homo sapiens_hsa006702.58513046
11RNA polymerase_Homo sapiens_hsa030202.44610372
12Vitamin B6 metabolism_Homo sapiens_hsa007502.31759111
13Steroid biosynthesis_Homo sapiens_hsa001002.30312703
14Nicotine addiction_Homo sapiens_hsa050332.26027894
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25857705
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24543993
17Alzheimers disease_Homo sapiens_hsa050102.22854627
18Base excision repair_Homo sapiens_hsa034102.21913306
19Synaptic vesicle cycle_Homo sapiens_hsa047212.03238559
20Huntingtons disease_Homo sapiens_hsa050162.02976276
21Vibrio cholerae infection_Homo sapiens_hsa051101.98023132
22Ether lipid metabolism_Homo sapiens_hsa005651.79680583
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.77167920
24Cell cycle_Homo sapiens_hsa041101.74089145
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73868137
26Sulfur relay system_Homo sapiens_hsa041221.58264497
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50016364
28GABAergic synapse_Homo sapiens_hsa047271.49459451
29Rheumatoid arthritis_Homo sapiens_hsa053231.46669762
30Phototransduction_Homo sapiens_hsa047441.46422973
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44360642
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43284852
33Sphingolipid metabolism_Homo sapiens_hsa006001.41286074
34RNA degradation_Homo sapiens_hsa030181.41032401
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39751346
36Serotonergic synapse_Homo sapiens_hsa047261.39490965
37Regulation of autophagy_Homo sapiens_hsa041401.35968323
38Basal transcription factors_Homo sapiens_hsa030221.35493985
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.33065734
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32997840
41Morphine addiction_Homo sapiens_hsa050321.27909918
42Glutamatergic synapse_Homo sapiens_hsa047241.11625711
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09342345
44Cardiac muscle contraction_Homo sapiens_hsa042601.07766694
45Taste transduction_Homo sapiens_hsa047421.03035720
46Selenocompound metabolism_Homo sapiens_hsa004501.00188136
47Autoimmune thyroid disease_Homo sapiens_hsa053200.98172534
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95014729
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93366708
50Circadian entrainment_Homo sapiens_hsa047130.93034312
51Purine metabolism_Homo sapiens_hsa002300.92454242
52Biosynthesis of amino acids_Homo sapiens_hsa012300.89907107
53Ribosome_Homo sapiens_hsa030100.88000489
54mRNA surveillance pathway_Homo sapiens_hsa030150.87537416
55Phagosome_Homo sapiens_hsa041450.86954976
56Linoleic acid metabolism_Homo sapiens_hsa005910.84334575
57Amphetamine addiction_Homo sapiens_hsa050310.84045031
58Carbon metabolism_Homo sapiens_hsa012000.83989938
59Arachidonic acid metabolism_Homo sapiens_hsa005900.83911362
60Axon guidance_Homo sapiens_hsa043600.83814166
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82862934
62Dopaminergic synapse_Homo sapiens_hsa047280.80608843
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80135912
64N-Glycan biosynthesis_Homo sapiens_hsa005100.80125273
65p53 signaling pathway_Homo sapiens_hsa041150.79901781
66Sulfur metabolism_Homo sapiens_hsa009200.78063638
67Olfactory transduction_Homo sapiens_hsa047400.75991671
68Pyrimidine metabolism_Homo sapiens_hsa002400.73745535
69Nucleotide excision repair_Homo sapiens_hsa034200.72338061
70Propanoate metabolism_Homo sapiens_hsa006400.71746291
71Cocaine addiction_Homo sapiens_hsa050300.71076303
72Long-term depression_Homo sapiens_hsa047300.69676501
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68605599
74Metabolic pathways_Homo sapiens_hsa011000.67199933
75Glutathione metabolism_Homo sapiens_hsa004800.66965495
76* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65450826
77Butanoate metabolism_Homo sapiens_hsa006500.62823146
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.62185541
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59276682
80Spliceosome_Homo sapiens_hsa030400.58232356
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.57978991
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56352730
83Fructose and mannose metabolism_Homo sapiens_hsa000510.55469676
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54093960
85Type I diabetes mellitus_Homo sapiens_hsa049400.52994332
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52573213
87Cholinergic synapse_Homo sapiens_hsa047250.50854296
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50568610
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48639734
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48516419
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48195215
92Calcium signaling pathway_Homo sapiens_hsa040200.47290645
93Pyruvate metabolism_Homo sapiens_hsa006200.44245911
94Tyrosine metabolism_Homo sapiens_hsa003500.43969323
95Histidine metabolism_Homo sapiens_hsa003400.43570430
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43502036
97Arginine and proline metabolism_Homo sapiens_hsa003300.43382004
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42815043
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.40967483
100Insulin secretion_Homo sapiens_hsa049110.39936653
101Pentose phosphate pathway_Homo sapiens_hsa000300.39911037
102Thyroid cancer_Homo sapiens_hsa052160.39408710
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38233369
104Epstein-Barr virus infection_Homo sapiens_hsa051690.37996721
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37782692
106Renin secretion_Homo sapiens_hsa049240.37679904
107Non-homologous end-joining_Homo sapiens_hsa034500.36684429
108Long-term potentiation_Homo sapiens_hsa047200.36453187
109Allograft rejection_Homo sapiens_hsa053300.35902238
110Hedgehog signaling pathway_Homo sapiens_hsa043400.35640154
111Fanconi anemia pathway_Homo sapiens_hsa034600.34506512
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33859532
113Ras signaling pathway_Homo sapiens_hsa040140.33028407
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32077688
115Shigellosis_Homo sapiens_hsa051310.30028995
116Viral carcinogenesis_Homo sapiens_hsa052030.29680973
117RNA transport_Homo sapiens_hsa030130.29587954
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29100265
119Oocyte meiosis_Homo sapiens_hsa041140.28474766
120Salivary secretion_Homo sapiens_hsa049700.27038735
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.25943338
122Peroxisome_Homo sapiens_hsa041460.25744654
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24891459
124Folate biosynthesis_Homo sapiens_hsa007900.23881265
125Homologous recombination_Homo sapiens_hsa034400.23689997
126Graft-versus-host disease_Homo sapiens_hsa053320.22844168
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22763335
128Lysosome_Homo sapiens_hsa041420.22294830
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.21132320
130Other glycan degradation_Homo sapiens_hsa005110.20927728
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20810932
132Asthma_Homo sapiens_hsa053100.20650236
133Phenylalanine metabolism_Homo sapiens_hsa003600.20133299
134Lysine degradation_Homo sapiens_hsa003100.20106342
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19757119
136Renal cell carcinoma_Homo sapiens_hsa052110.19050315
137Fatty acid metabolism_Homo sapiens_hsa012120.18330281
138Alcoholism_Homo sapiens_hsa050340.18277973
139Endocytosis_Homo sapiens_hsa041440.18053212
140Galactose metabolism_Homo sapiens_hsa000520.16558315
141Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.13510574
142Legionellosis_Homo sapiens_hsa051340.12838385
143Chemical carcinogenesis_Homo sapiens_hsa052040.10674750
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09547271
145Herpes simplex infection_Homo sapiens_hsa051680.08656868
146Retinol metabolism_Homo sapiens_hsa008300.07774498
147HIF-1 signaling pathway_Homo sapiens_hsa040660.05942189
148Apoptosis_Homo sapiens_hsa042100.05524963
149Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05139861
150Bladder cancer_Homo sapiens_hsa052190.04743196

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