UFM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)9.65741268
2COPI coating of Golgi vesicle (GO:0048205)9.65741268
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.29800939
4signal peptide processing (GO:0006465)7.26866408
5regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022357.13548677
6protein maturation by protein folding (GO:0022417)6.66605619
7protein retention in ER lumen (GO:0006621)6.52164618
8COPII vesicle coating (GO:0048208)6.23317658
9endocrine pancreas development (GO:0031018)5.86988299
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.58100263
11regulation of type B pancreatic cell apoptotic process (GO:2000674)5.41433389
12peptide hormone processing (GO:0016486)5.14797828
13DNA double-strand break processing (GO:0000729)5.13144834
14activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.04567479
15response to xenobiotic stimulus (GO:0009410)4.87645973
16exocrine pancreas development (GO:0031017)4.85864185
17ER overload response (GO:0006983)4.82181211
18sequestering of metal ion (GO:0051238)4.80964530
19positive regulation of nuclease activity (GO:0032075)4.80009239
20ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.56990969
21ribonucleoprotein complex disassembly (GO:0032988)4.44041161
22endoplasmic reticulum unfolded protein response (GO:0030968)4.41535607
23regulation of nuclease activity (GO:0032069)4.39040356
24vesicle coating (GO:0006901)4.39032841
25proteasome assembly (GO:0043248)4.34443563
26cellular response to unfolded protein (GO:0034620)4.29943208
27S-adenosylmethionine metabolic process (GO:0046500)4.16942778
28neural tube formation (GO:0001841)4.15318279
29ER-nucleus signaling pathway (GO:0006984)4.13824272
30cellular response to topologically incorrect protein (GO:0035967)4.13784826
31glandular epithelial cell differentiation (GO:0002067)4.07518502
32inositol phosphate catabolic process (GO:0071545)3.99464655
33intestinal cholesterol absorption (GO:0030299)3.97210644
34inositol phosphate dephosphorylation (GO:0046855)3.93960085
35phosphorylated carbohydrate dephosphorylation (GO:0046838)3.93960085
36platelet dense granule organization (GO:0060155)3.93629064
37respiratory chain complex IV assembly (GO:0008535)3.93286005
38organelle disassembly (GO:1903008)3.91924823
39positive regulation of insulin secretion (GO:0032024)3.85015283
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.77636616
41L-phenylalanine catabolic process (GO:0006559)3.77636616
42protein N-linked glycosylation via asparagine (GO:0018279)3.76516770
43ER to Golgi vesicle-mediated transport (GO:0006888)3.75289095
44response to nitrosative stress (GO:0051409)3.73220812
45peptidyl-asparagine modification (GO:0018196)3.71503203
46* response to endoplasmic reticulum stress (GO:0034976)3.66061169
47insulin secretion (GO:0030073)3.64819666
48nitric oxide mediated signal transduction (GO:0007263)3.58605647
49negative regulation of DNA recombination (GO:0045910)3.54961030
50UDP-N-acetylglucosamine metabolic process (GO:0006047)3.53999336
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.53099093
52L-phenylalanine metabolic process (GO:0006558)3.53099093
53polyol catabolic process (GO:0046174)3.51620195
54protein N-linked glycosylation (GO:0006487)3.47701113
55regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.42688815
56regulation of insulin secretion (GO:0050796)3.40670172
57somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.37510554
58isotype switching (GO:0045190)3.37510554
59somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.37510554
60regulation of oxidative phosphorylation (GO:0002082)3.30763657
61cullin deneddylation (GO:0010388)3.30727524
62response to unfolded protein (GO:0006986)3.30008670
63type B pancreatic cell development (GO:0003323)3.29901674
64eosinophil chemotaxis (GO:0048245)3.26031490
65intestinal absorption (GO:0050892)3.26011402
66positive regulation of peptide hormone secretion (GO:0090277)3.24644436
67cilium morphogenesis (GO:0060271)3.23682603
68response to topologically incorrect protein (GO:0035966)3.19984405
69heparin biosynthetic process (GO:0030210)3.19924872
70heparin metabolic process (GO:0030202)3.19924872
71protein deneddylation (GO:0000338)3.19341678
72GDP-mannose metabolic process (GO:0019673)3.17993447
73protein localization to cilium (GO:0061512)3.17242528
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.14098358
754-hydroxyproline metabolic process (GO:0019471)3.12673561
76regulation of peptide hormone secretion (GO:0090276)3.12104627
77cytochrome complex assembly (GO:0017004)3.12011546
78intra-Golgi vesicle-mediated transport (GO:0006891)3.11801279
79negative regulation of norepinephrine secretion (GO:0010700)3.11679310
80positive regulation of peptide secretion (GO:0002793)3.11647144
81glandular epithelial cell development (GO:0002068)3.11166014
82glycosphingolipid biosynthetic process (GO:0006688)3.09882833
83toxin metabolic process (GO:0009404)3.08807831
84cell redox homeostasis (GO:0045454)3.07648763
85axoneme assembly (GO:0035082)3.07442046
86regulation of peptide secretion (GO:0002791)3.06161555
87preassembly of GPI anchor in ER membrane (GO:0016254)3.05111755
88membrane budding (GO:0006900)3.04666246
89keratinocyte development (GO:0003334)3.02162086
90nucleotide-sugar biosynthetic process (GO:0009226)3.02158286
91positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.01877700
92mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.01877700
93protein localization to Golgi apparatus (GO:0034067)3.00880113
94L-fucose catabolic process (GO:0042355)2.98340017
95fucose catabolic process (GO:0019317)2.98340017
96L-fucose metabolic process (GO:0042354)2.98340017
97protein complex biogenesis (GO:0070271)2.98248581
98histone H2A ubiquitination (GO:0033522)2.98239583
99purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.97503104
1003-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.97503104
101negative regulation of insulin secretion (GO:0046676)2.96587315
102nucleotide transmembrane transport (GO:1901679)2.94959863
103positive regulation of protein autophosphorylation (GO:0031954)2.91955245
104protein-cofactor linkage (GO:0018065)2.91063315
105positive regulation of mitochondrial fission (GO:0090141)2.90499837
106cellular response to vitamin D (GO:0071305)2.90317093
107regulation of cilium movement (GO:0003352)2.90039780
108macroautophagy (GO:0016236)2.88619159
109protein targeting to Golgi (GO:0000042)2.88076043
110establishment of protein localization to Golgi (GO:0072600)2.87755776
111L-ascorbic acid metabolic process (GO:0019852)2.87297884
112cellular zinc ion homeostasis (GO:0006882)2.85113163
113nitric oxide biosynthetic process (GO:0006809)2.85034116
114peptide metabolic process (GO:0006518)2.83608358
115negative regulation of catecholamine secretion (GO:0033604)2.83269458
116gamma-aminobutyric acid transport (GO:0015812)2.81185689
117peptide hormone secretion (GO:0030072)2.80730961
118regulation of glucokinase activity (GO:0033131)2.80055440
119regulation of hexokinase activity (GO:1903299)2.80055440
120water-soluble vitamin biosynthetic process (GO:0042364)2.79556527
121prenylation (GO:0097354)2.79233532
122protein prenylation (GO:0018342)2.79233532
123peptide secretion (GO:0002790)2.78769491
124adenosine metabolic process (GO:0046085)2.78392449
125eosinophil migration (GO:0072677)2.78263694
126aldehyde catabolic process (GO:0046185)2.77013196
127protein neddylation (GO:0045116)2.76458411
128nonmotile primary cilium assembly (GO:0035058)2.75133424
129regulation of hormone secretion (GO:0046883)2.73905207
130columnar/cuboidal epithelial cell development (GO:0002066)2.73105555
131epithelial cilium movement (GO:0003351)2.71683357
132hydrogen peroxide biosynthetic process (GO:0050665)2.70247275
133L-alpha-amino acid transmembrane transport (GO:1902475)2.69245591
134mitochondrial respiratory chain complex assembly (GO:0033108)2.69017774
135mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.68225427
136peptidyl-histidine modification (GO:0018202)2.68093330
137C-terminal protein lipidation (GO:0006501)2.67889758
138intraciliary transport (GO:0042073)2.65721482
139response to hexose (GO:0009746)2.65051677
140mannosylation (GO:0097502)2.64787975
141ribosome assembly (GO:0042255)2.64504085
142Golgi vesicle transport (GO:0048193)2.64480940
143intestinal epithelial cell development (GO:0060576)2.64166592
144positive regulation of hormone secretion (GO:0046887)2.63650603
145protein K11-linked ubiquitination (GO:0070979)2.63199156
146zinc ion transport (GO:0006829)2.62592496
147regulation of peptide transport (GO:0090087)2.62253803
148L-methionine salvage (GO:0071267)2.61860583
149L-methionine biosynthetic process (GO:0071265)2.61860583
150amino acid salvage (GO:0043102)2.61860583
151tricarboxylic acid metabolic process (GO:0072350)2.61829220
152positive regulation of glycolytic process (GO:0045821)2.61684089
153negative regulation of JUN kinase activity (GO:0043508)2.60810323
154GPI anchor metabolic process (GO:0006505)2.60571265
155response to redox state (GO:0051775)2.60219883
156response to glucose (GO:0009749)2.59707173
157transcytosis (GO:0045056)2.59646665
158glycolipid biosynthetic process (GO:0009247)2.59603990
159C-terminal protein amino acid modification (GO:0018410)2.59244080
160negative regulation of peptide hormone secretion (GO:0090278)2.58998701
161mitochondrial respiratory chain complex I assembly (GO:0032981)2.58519405
162NADH dehydrogenase complex assembly (GO:0010257)2.58519405
163mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58519405
164proline biosynthetic process (GO:0006561)2.58310770
165protein K11-linked deubiquitination (GO:0035871)2.57073562
166digestion (GO:0007586)2.56825955
167regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.56634095
168response to monosaccharide (GO:0034284)2.56083335
169anterograde synaptic vesicle transport (GO:0048490)2.55053395
170Golgi organization (GO:0007030)2.54809773
171magnesium ion transport (GO:0015693)2.54463915
172zinc ion transmembrane transport (GO:0071577)2.53294527
173negative regulation of peptide secretion (GO:0002792)2.52354102
174cysteine metabolic process (GO:0006534)2.50635226
175regulation of mitochondrial depolarization (GO:0051900)2.49843748
176nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46591440
177prostate gland growth (GO:0060736)2.46053555
178cellular ketone body metabolic process (GO:0046950)2.45248249
179mitochondrial DNA replication (GO:0006264)2.44821250
180dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.44298242
181double-strand break repair via nonhomologous end joining (GO:0006303)2.44206228
182non-recombinational repair (GO:0000726)2.44206228
183epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.43902083
184cellular response to glucose starvation (GO:0042149)2.43690045
185vascular smooth muscle contraction (GO:0014829)2.42884973
186protein K48-linked ubiquitination (GO:0070936)2.40947998
187inner ear receptor stereocilium organization (GO:0060122)2.40898229
188GPI anchor biosynthetic process (GO:0006506)2.40570285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.49699606
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.25668526
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.58601872
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.52647160
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.95831058
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.94537456
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.86171246
8GATA1_22025678_ChIP-Seq_K562_Human2.80497214
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78890699
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.76419064
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.75586214
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.48862229
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.39158830
14FUS_26573619_Chip-Seq_HEK293_Human2.38875168
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.36078494
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.32151059
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.29726310
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29366346
19EWS_26573619_Chip-Seq_HEK293_Human2.25370580
20DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.19294902
21TAF15_26573619_Chip-Seq_HEK293_Human2.18100033
22IGF1R_20145208_ChIP-Seq_DFB_Human2.15102929
23EGR1_23403033_ChIP-Seq_LIVER_Mouse2.12807917
24GBX2_23144817_ChIP-Seq_PC3_Human2.09880322
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08305904
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.06408776
27* P300_19829295_ChIP-Seq_ESCs_Human2.05630661
28SOX2_27498859_Chip-Seq_STOMACH_Mouse2.03840436
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.03469272
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00092933
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94378428
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.92102033
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90622691
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89793685
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84687929
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80847203
37CLOCK_20551151_ChIP-Seq_293T_Human1.80630974
38PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.80238324
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76512414
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.76100067
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.76100067
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75414885
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71371895
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.70692795
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69520293
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.69321538
47* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63110307
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61367849
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60935191
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60095352
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.57208814
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57038484
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56344557
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55108460
55SOX2_20726797_ChIP-Seq_SW620_Human1.55050155
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.52443390
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52217881
58* NANOG_18555785_Chip-Seq_ESCs_Mouse1.50083893
59* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49663370
60* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48977358
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46263217
62ER_23166858_ChIP-Seq_MCF-7_Human1.46247794
63* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43341947
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43319220
65CBP_20019798_ChIP-Seq_JUKART_Human1.42244825
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42244825
67SMAD4_21799915_ChIP-Seq_A2780_Human1.41929071
68FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.40744113
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.39335618
70P53_22387025_ChIP-Seq_ESCs_Mouse1.37744609
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37423045
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35868139
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35511877
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35439991
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.34519996
76* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.34047282
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32832035
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32810021
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31677124
80TFEB_21752829_ChIP-Seq_HELA_Human1.31122899
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30943505
82ERG_20517297_ChIP-Seq_VCAP_Human1.28387326
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27574476
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26650722
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26429668
86* CMYC_18555785_Chip-Seq_ESCs_Mouse1.26272206
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25814680
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.23840545
89* ELK1_22589737_ChIP-Seq_MCF10A_Human1.23070190
90CDX2_22108803_ChIP-Seq_LS180_Human1.22975153
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.22639762
92* STAT3_23295773_ChIP-Seq_U87_Human1.21771919
93AR_25329375_ChIP-Seq_VCAP_Human1.21425546
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20917276
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20332565
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.19917715
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18770779
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18759745
99BCAT_22108803_ChIP-Seq_LS180_Human1.18728906
100* ELK1_19687146_ChIP-ChIP_HELA_Human1.17576229
101SOX2_19829295_ChIP-Seq_ESCs_Human1.17044466
102NANOG_19829295_ChIP-Seq_ESCs_Human1.17044466
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16372628
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15419571
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15041947
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.13062071
107P300_18555785_Chip-Seq_ESCs_Mouse1.12991953
108* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12747571
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12155203
110FOXA1_25552417_ChIP-Seq_VCAP_Human1.10922287
111MYC_18940864_ChIP-ChIP_HL60_Human1.10711072
112* TCF4_23295773_ChIP-Seq_U87_Human1.10326238
113JUN_21703547_ChIP-Seq_K562_Human1.09533326
114FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09336371
115* NMYC_18555785_Chip-Seq_ESCs_Mouse1.09287192
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08748694
117TCF4_22108803_ChIP-Seq_LS180_Human1.08538755
118VDR_22108803_ChIP-Seq_LS180_Human1.08264812
119EST1_17652178_ChIP-ChIP_JURKAT_Human1.08235251
120TP53_18474530_ChIP-ChIP_U2OS_Human1.07558273
121OCT4_18555785_Chip-Seq_ESCs_Mouse1.06754632
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06449633
123DCP1A_22483619_ChIP-Seq_HELA_Human1.05919850
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.05523656
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05474775
126* CJUN_26792858_Chip-Seq_BT549_Human1.04078849
127GATA4_25053715_ChIP-Seq_YYC3_Human1.03254213
128TP53_22573176_ChIP-Seq_HFKS_Human1.01775955
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00632028
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00201183
131PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97624913
132GATA3_24758297_ChIP-Seq_MCF-7_Human0.95371828
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95265821
134ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94388616
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94381079
136ETS1_20019798_ChIP-Seq_JURKAT_Human0.94320154
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93323320
138FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91855488
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91279309
140ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90610268
141ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90281043
142ESR1_21235772_ChIP-Seq_MCF-7_Human0.89665074
143* AR_20517297_ChIP-Seq_VCAP_Human0.83907415
144EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83658267
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83552917
146ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81939604
147BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81698840
148FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81353512
149FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.80507496
150CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.79866621
151GATA3_26560356_Chip-Seq_TH2_Human0.78795770
152HTT_18923047_ChIP-ChIP_STHdh_Human0.78422445
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77752999
154RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77592666
155SOX17_20123909_ChIP-Seq_XEN_Mouse0.77402395
156SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77197508
157GATA6_25053715_ChIP-Seq_YYC3_Human0.76551421
158* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75235705
159ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75178900
160PIAS1_25552417_ChIP-Seq_VCAP_Human0.73431889
161CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72583704
162* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.71769314
163ZNF274_21170338_ChIP-Seq_K562_Hela0.69950738
164CHD1_26751641_Chip-Seq_LNCaP_Human0.69604472
165EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.68312554
166TBX5_21415370_ChIP-Seq_HL-1_Mouse0.66982073
167TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66374384
168SRF_21415370_ChIP-Seq_HL-1_Mouse0.65421795
169ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.65238081
170ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.64562717
171FOXA2_19822575_ChIP-Seq_HepG2_Human0.64395328
172FOXA1_27270436_Chip-Seq_PROSTATE_Human0.63429180
173FOXA1_25329375_ChIP-Seq_VCAP_Human0.63429180
174* NCOR_22424771_ChIP-Seq_293T_Human0.62338175
175* STAT3_18555785_Chip-Seq_ESCs_Mouse0.61485769
176VDR_23849224_ChIP-Seq_CD4+_Human0.61296124
177* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.60537801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation4.36524099
2MP0003195_calcinosis4.35446065
3MP0002877_abnormal_melanocyte_morpholog4.13753220
4MP0002693_abnormal_pancreas_physiology3.98685270
5MP0002139_abnormal_hepatobiliary_system3.69395635
6MP0010386_abnormal_urinary_bladder3.46934251
7MP0009780_abnormal_chondrocyte_physiolo3.44788623
8MP0001944_abnormal_pancreas_morphology3.41026843
9MP0005220_abnormal_exocrine_pancreas3.28205761
10MP0003283_abnormal_digestive_organ3.28171379
11MP0005365_abnormal_bile_salt3.24839841
12MP0002102_abnormal_ear_morphology3.23569621
13MP0000013_abnormal_adipose_tissue3.12333831
14MP0005379_endocrine/exocrine_gland_phen3.07172630
15MP0002909_abnormal_adrenal_gland3.01401877
16MP0000516_abnormal_urinary_system2.60709436
17MP0005367_renal/urinary_system_phenotyp2.60709436
18MP0002837_dystrophic_cardiac_calcinosis2.54462390
19MP0005085_abnormal_gallbladder_physiolo2.48908476
20MP0005058_abnormal_lysosome_morphology2.34572425
21MP0001984_abnormal_olfaction2.31414350
22MP0002138_abnormal_hepatobiliary_system2.29309747
23MP0005083_abnormal_biliary_tract2.25484511
24MP0005253_abnormal_eye_physiology2.23771412
25MP0002078_abnormal_glucose_homeostasis2.20849699
26MP0001666_abnormal_nutrient_absorption2.16794219
27MP0003183_abnormal_peptide_metabolism2.15747204
28MP0008789_abnormal_olfactory_epithelium2.10048328
29MP0008057_abnormal_DNA_replication2.08187806
30MP0003252_abnormal_bile_duct2.02982870
31MP0005360_urolithiasis1.96606785
32MP0000569_abnormal_digit_pigmentation1.93970961
33MP0008877_abnormal_DNA_methylation1.92617353
34MP0009643_abnormal_urine_homeostasis1.91641227
35MP0003011_delayed_dark_adaptation1.91111156
36MP0003950_abnormal_plasma_membrane1.86743658
37MP0004134_abnormal_chest_morphology1.86080100
38MP0000678_abnormal_parathyroid_gland1.85773557
39MP0003868_abnormal_feces_composition1.84746120
40MP0003806_abnormal_nucleotide_metabolis1.83792006
41MP0009384_cardiac_valve_regurgitation1.81607000
42MP0004484_altered_response_of1.75381880
43MP0005551_abnormal_eye_electrophysiolog1.74293778
44MP0009697_abnormal_copulation1.69021193
45MP0002896_abnormal_bone_mineralization1.68918183
46MP0001529_abnormal_vocalization1.67514256
47MP0004215_abnormal_myocardial_fiber1.65154470
48MP0005084_abnormal_gallbladder_morpholo1.64530327
49MP0005257_abnormal_intraocular_pressure1.61642195
50MP0005636_abnormal_mineral_homeostasis1.60640494
51MP0005332_abnormal_amino_acid1.57963268
52MP0001542_abnormal_bone_strength1.57448868
53MP0001765_abnormal_ion_homeostasis1.55406154
54MP0001986_abnormal_taste_sensitivity1.54258659
55MP0002876_abnormal_thyroid_physiology1.53890024
56MP0005499_abnormal_olfactory_system1.51744372
57MP0005394_taste/olfaction_phenotype1.51744372
58MP0001501_abnormal_sleep_pattern1.50689436
59MP0001756_abnormal_urination1.49302646
60MP0009046_muscle_twitch1.49280787
61MP0008875_abnormal_xenobiotic_pharmacok1.44696535
62MP0003880_abnormal_central_pattern1.43478251
63MP0004142_abnormal_muscle_tone1.37614680
64MP0005535_abnormal_body_temperature1.36404741
65MP0002736_abnormal_nociception_after1.36244752
66MP0002009_preneoplasia1.34848238
67MP0000372_irregular_coat_pigmentation1.34441459
68MP0000427_abnormal_hair_cycle1.34003165
69MP0000613_abnormal_salivary_gland1.31304266
70MP0008058_abnormal_DNA_repair1.27969307
71MP0004147_increased_porphyrin_level1.26290217
72MP0003959_abnormal_lean_body1.25099237
73MP0002118_abnormal_lipid_homeostasis1.24848275
74MP0003953_abnormal_hormone_level1.23752768
75MP0002751_abnormal_autonomic_nervous1.20281537
76MP0003172_abnormal_lysosome_physiology1.19683282
77MP0002638_abnormal_pupillary_reflex1.18119737
78MP0000003_abnormal_adipose_tissue1.17933522
79MP0005646_abnormal_pituitary_gland1.17849779
80MP0004264_abnormal_extraembryonic_tissu1.17229879
81MP0005310_abnormal_salivary_gland1.15990863
82MP0001188_hyperpigmentation1.13667737
83MP0005408_hypopigmentation1.13316208
84MP0006072_abnormal_retinal_apoptosis1.12366119
85MP0006054_spinal_hemorrhage1.12264645
86MP0002163_abnormal_gland_morphology1.11988547
87MP0003186_abnormal_redox_activity1.11956042
88MP0003221_abnormal_cardiomyocyte_apopto1.11878977
89MP0005248_abnormal_Harderian_gland1.09496040
90MP0005386_behavior/neurological_phenoty1.09465687
91MP0004924_abnormal_behavior1.09465687
92MP0001879_abnormal_lymphatic_vessel1.04936752
93MP0003633_abnormal_nervous_system1.04358750
94MP0003718_maternal_effect1.04173989
95MP0000230_abnormal_systemic_arterial1.02900279
96MP0000538_abnormal_urinary_bladder1.02601649
97MP0000681_abnormal_thyroid_gland1.02531741
98MP0010678_abnormal_skin_adnexa1.02327116
99MP0003300_gastrointestinal_ulcer1.02317330
100MP0002254_reproductive_system_inflammat1.01517233
101MP0010329_abnormal_lipoprotein_level1.00577126
102MP0003787_abnormal_imprinting1.00249317
103MP0000631_abnormal_neuroendocrine_gland0.99508549
104MP0000609_abnormal_liver_physiology0.97620632
105MP0000462_abnormal_digestive_system0.97148475
106MP0002166_altered_tumor_susceptibility0.97025401
107MP0002928_abnormal_bile_duct0.94579220
108MP0005391_vision/eye_phenotype0.89592191
109MP0008995_early_reproductive_senescence0.88803971
110MP0002272_abnormal_nervous_system0.88435385
111MP0002938_white_spotting0.88358300
112MP0001764_abnormal_homeostasis0.87256193
113MP0009642_abnormal_blood_homeostasis0.86544938
114MP0008438_abnormal_cutaneous_collagen0.86135658
115MP0005319_abnormal_enzyme/_coenzyme0.84726010
116MP0005075_abnormal_melanosome_morpholog0.84203362
117MP0002233_abnormal_nose_morphology0.83491446
118MP0002006_tumorigenesis0.83360325
119MP0003137_abnormal_impulse_conducting0.82094376
120MP0002229_neurodegeneration0.81813478
121MP0004885_abnormal_endolymph0.81002960
122MP0009785_altered_susceptibility_to0.80977420
123MP0001299_abnormal_eye_distance/0.80918553
124MP0005448_abnormal_energy_balance0.80820320
125MP0010234_abnormal_vibrissa_follicle0.80804350
126MP0009745_abnormal_behavioral_response0.80153233
127MP0005275_abnormal_skin_tensile0.79807451
128MP0006036_abnormal_mitochondrial_physio0.79251083
129MP0000647_abnormal_sebaceous_gland0.78594737
130MP0002160_abnormal_reproductive_system0.78393696
131MP0004019_abnormal_vitamin_homeostasis0.78239349
132MP0001486_abnormal_startle_reflex0.77937588
133MP0003122_maternal_imprinting0.76561825
134MP0001664_abnormal_digestion0.75985675
135MP0000383_abnormal_hair_follicle0.75846045
136MP0002090_abnormal_vision0.75692106
137MP0003786_premature_aging0.75680117
138MP0003795_abnormal_bone_structure0.75607438
139MP0004782_abnormal_surfactant_physiolog0.75546385
140MP0004270_analgesia0.74306255
141MP0001440_abnormal_grooming_behavior0.74170077
142MP0003121_genomic_imprinting0.74014716
143MP0001177_atelectasis0.73518266
144MP0005389_reproductive_system_phenotype0.73375174
145MP0001346_abnormal_lacrimal_gland0.71789800
146MP0001191_abnormal_skin_condition0.71505073
147MP0005334_abnormal_fat_pad0.70495994
148MP0000639_abnormal_adrenal_gland0.69978552
149MP0002234_abnormal_pharynx_morphology0.67569555
150MP0001661_extended_life_span0.67168329
151MP0009840_abnormal_foam_cell0.67162096
152MP0002295_abnormal_pulmonary_circulatio0.66814718
153MP0008469_abnormal_protein_level0.64146610
154MP0001348_abnormal_lacrimal_gland0.59649545
155MP0005187_abnormal_penis_morphology0.56931253
156MP0001881_abnormal_mammary_gland0.56737398
157MP0001919_abnormal_reproductive_system0.56602682
158MP0003436_decreased_susceptibility_to0.54400645
159MP0001533_abnormal_skeleton_physiology0.52692276
160MP0001845_abnormal_inflammatory_respons0.52180521
161MP0005645_abnormal_hypothalamus_physiol0.51799426
162MP0005452_abnormal_adipose_tissue0.49754969
163MP0003724_increased_susceptibility_to0.48900235
164MP0005584_abnormal_enzyme/coenzyme_acti0.48327212
165MP0005375_adipose_tissue_phenotype0.48265354
166MP0002136_abnormal_kidney_physiology0.48142715
167MP0003890_abnormal_embryonic-extraembry0.47994401
168MP0000598_abnormal_liver_morphology0.47917396
169MP0000163_abnormal_cartilage_morphology0.47445566

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)6.29843271
2Hypoglycemic seizures (HP:0002173)6.00950434
3Hypoglycemic coma (HP:0001325)5.99400806
4Symptomatic seizures (HP:0011145)5.42978710
5Conjugated hyperbilirubinemia (HP:0002908)5.18306704
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.32568243
7Hyperglycemia (HP:0003074)4.30865758
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.29341925
9Ketoacidosis (HP:0001993)4.15853829
10Insulin-resistant diabetes mellitus (HP:0000831)4.11226396
11Generalized aminoaciduria (HP:0002909)3.84184289
12Late onset (HP:0003584)3.81215416
13Abnormality of the intrinsic pathway (HP:0010989)3.60422342
14Urinary glycosaminoglycan excretion (HP:0003541)3.58682764
15Mucopolysacchariduria (HP:0008155)3.58682764
16Medial flaring of the eyebrow (HP:0010747)3.58388122
17Thyroiditis (HP:0100646)3.56095336
18Dysostosis multiplex (HP:0000943)3.55994887
19Pancreatic cysts (HP:0001737)3.51804145
20Metaphyseal dysplasia (HP:0100255)3.46928599
21Abnormality of endocrine pancreas physiology (HP:0012093)3.43922195
22Abnormality of the pancreatic islet cells (HP:0006476)3.43922195
23Renal cortical cysts (HP:0000803)3.35279720
24Abnormality of polysaccharide metabolism (HP:0011012)3.28854783
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.28854783
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.28854783
273-Methylglutaconic aciduria (HP:0003535)3.25540356
28Congenital primary aphakia (HP:0007707)3.24833515
29Progressive macrocephaly (HP:0004481)3.19914315
30Vacuolated lymphocytes (HP:0001922)3.17967001
31Gait imbalance (HP:0002141)3.14688250
32Abnormality of calcium-phosphate metabolism (HP:0100530)3.12889331
33Gout (HP:0001997)3.12251757
34Nephrogenic diabetes insipidus (HP:0009806)3.04171872
35Pancreatic islet-cell hyperplasia (HP:0004510)3.02788414
36Ketosis (HP:0001946)2.99961128
37Abnormal pancreas size (HP:0012094)2.98975592
38Large for gestational age (HP:0001520)2.97937179
39Abnormality of the renal cortex (HP:0011035)2.91594450
40Decreased circulating renin level (HP:0003351)2.90762117
41Molar tooth sign on MRI (HP:0002419)2.89253829
42Abnormality of midbrain morphology (HP:0002418)2.89253829
43Neuroendocrine neoplasm (HP:0100634)2.85325158
44Amyotrophic lateral sclerosis (HP:0007354)2.83004009
45Pancreatic fibrosis (HP:0100732)2.81698041
46Congenital, generalized hypertrichosis (HP:0004540)2.77170280
47Abnormality of urine glucose concentration (HP:0011016)2.75073277
48Glycosuria (HP:0003076)2.75073277
49Hyperphosphaturia (HP:0003109)2.74450322
50Abnormality of the common coagulation pathway (HP:0010990)2.73630253
51Methylmalonic acidemia (HP:0002912)2.72132362
52Chronic hepatic failure (HP:0100626)2.70229039
53Intrahepatic cholestasis (HP:0001406)2.68904095
54Pheochromocytoma (HP:0002666)2.67182385
55Hepatocellular necrosis (HP:0001404)2.65297302
56Insulin resistance (HP:0000855)2.61279580
57True hermaphroditism (HP:0010459)2.60965856
58Increased CSF lactate (HP:0002490)2.60649509
59Agitation (HP:0000713)2.59510667
60Nephronophthisis (HP:0000090)2.59224900
61Mitochondrial inheritance (HP:0001427)2.56510869
62Exertional dyspnea (HP:0002875)2.53871406
63Thoracolumbar scoliosis (HP:0002944)2.51486118
64Abnormal protein glycosylation (HP:0012346)2.49280559
65Abnormal glycosylation (HP:0012345)2.49280559
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.49280559
67Abnormal protein N-linked glycosylation (HP:0012347)2.49280559
68Hypokalemia (HP:0002900)2.46337360
69Genital tract atresia (HP:0001827)2.45232290
70Abdominal distention (HP:0003270)2.44625718
71Fat malabsorption (HP:0002630)2.41226690
72Hyperventilation (HP:0002883)2.39114349
73Acute hepatic failure (HP:0006554)2.38593678
74Exocrine pancreatic insufficiency (HP:0001738)2.37710517
75Protuberant abdomen (HP:0001538)2.33717557
76Vaginal atresia (HP:0000148)2.33379090
77Osteomalacia (HP:0002749)2.32886227
78Intestinal atresia (HP:0011100)2.32560017
79Hypophosphatemia (HP:0002148)2.32454878
80Progressive inability to walk (HP:0002505)2.32453054
81Abnormality of monocarboxylic acid metabolism (HP:0010996)2.32079920
82Abnormality of purine metabolism (HP:0004352)2.31026796
83Atrophy/Degeneration involving motor neurons (HP:0007373)2.30886172
84Abnormal urine phosphate concentration (HP:0012599)2.28479192
85Abnormality of the renal medulla (HP:0100957)2.26951310
86Hyperactive renin-angiotensin system (HP:0000841)2.26838049
87Increased hepatocellular lipid droplets (HP:0006565)2.26155865
88Cutaneous melanoma (HP:0012056)2.20856436
89Severe combined immunodeficiency (HP:0004430)2.19703326
90Prolonged partial thromboplastin time (HP:0003645)2.19344293
91Abnormality of renin-angiotensin system (HP:0000847)2.18161029
92Xanthomatosis (HP:0000991)2.18065515
93Peritonitis (HP:0002586)2.17050805
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14371559
95Type I transferrin isoform profile (HP:0003642)2.12595615
96Hyperbilirubinemia (HP:0002904)2.11402855
97Beaking of vertebral bodies (HP:0004568)2.07826203
98Postaxial hand polydactyly (HP:0001162)2.06934047
99Retinal atrophy (HP:0001105)2.06126795
100Irregular vertebral endplates (HP:0003301)2.05639544
101Elevated alkaline phosphatase (HP:0003155)2.04060427
102Progressive neurologic deterioration (HP:0002344)2.03994165
103Aplasia/Hypoplasia of the fovea (HP:0008060)2.03895859
104Hypoplasia of the fovea (HP:0007750)2.03895859
105Dyskinesia (HP:0100660)2.03868213
106Hyperparathyroidism (HP:0000843)2.03085004
107Hypothermia (HP:0002045)2.02181628
108Furrowed tongue (HP:0000221)2.01976773
109Lipid accumulation in hepatocytes (HP:0006561)2.01497291
110Hypsarrhythmia (HP:0002521)2.01385885
111Bile duct proliferation (HP:0001408)2.00550472
112Abnormal biliary tract physiology (HP:0012439)2.00550472
113Abnormality of vitamin B metabolism (HP:0004340)1.99811033
114Acute encephalopathy (HP:0006846)1.98259515
115Abnormal albumin level (HP:0012116)1.98024352
116Hypoalbuminemia (HP:0003073)1.98024352
117Abnormality of alkaline phosphatase activity (HP:0004379)1.97875889
118EEG with generalized epileptiform discharges (HP:0011198)1.97821442
119Abnormality of the fovea (HP:0000493)1.97011561
120Abnormal enzyme/coenzyme activity (HP:0012379)1.94506787
121Irritability (HP:0000737)1.93917214
122Conjunctival hamartoma (HP:0100780)1.93740532
123Biliary tract neoplasm (HP:0100574)1.93153245
124Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93030470
125Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93030470
126Dysautonomia (HP:0002459)1.92180270
127Epileptiform EEG discharges (HP:0011182)1.92058266
128Prominent metopic ridge (HP:0005487)1.91495724
129Stomatitis (HP:0010280)1.90963633
130Increased circulating renin level (HP:0000848)1.90524310
131Acute necrotizing encephalopathy (HP:0006965)1.90384491
132Thyroid carcinoma (HP:0002890)1.90016847
133Absent speech (HP:0001344)1.89171985
134Restlessness (HP:0000711)1.88430759
135Methylmalonic aciduria (HP:0012120)1.88395989
136Fair hair (HP:0002286)1.87625049
137Pancreatitis (HP:0001733)1.87186248
138Hypokalemic alkalosis (HP:0001949)1.86010437
139Dynein arm defect of respiratory motile cilia (HP:0012255)1.84977654
140Absent/shortened dynein arms (HP:0200106)1.84977654
141Curly hair (HP:0002212)1.83898278
142Hyperglycinemia (HP:0002154)1.83487795
143Specific learning disability (HP:0001328)1.83422229
144Cerebral edema (HP:0002181)1.83205396
145Gaze-evoked nystagmus (HP:0000640)1.82867411
146Abnormality of potassium homeostasis (HP:0011042)1.82347706
147Colon cancer (HP:0003003)1.82150359
148Skin nodule (HP:0200036)1.81986114
149Chronic diarrhea (HP:0002028)1.81756595
150Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79834854
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.79776396
152Hepatic necrosis (HP:0002605)1.79649958
153Poor coordination (HP:0002370)1.79168501
154Decreased testicular size (HP:0008734)1.78378565
155Decreased subcutaneous fat (HP:0001002)1.78337806
156Metaphyseal irregularity (HP:0003025)1.78057248
157Thyroid-stimulating hormone excess (HP:0002925)1.77808595
158Abnormal mitochondria in muscle tissue (HP:0008316)1.77783776
159Hypoproteinemia (HP:0003075)1.77610571
160Proximal tubulopathy (HP:0000114)1.77344063
161Type I diabetes mellitus (HP:0100651)1.77163534
162Villous atrophy (HP:0011473)1.76603557
163Abnormality of small intestinal villus morphology (HP:0011472)1.76603557
164Aplasia/Hypoplasia of the lens (HP:0008063)1.75113623
165Glucose intolerance (HP:0000833)1.74365536
166Renal Fanconi syndrome (HP:0001994)1.74019333
167Short tibia (HP:0005736)1.72846696
168Steatorrhea (HP:0002570)1.72764217
169Abnormality of macular pigmentation (HP:0008002)1.71379724
170Palpitations (HP:0001962)1.71228270
171Aplasia/Hypoplasia of the tibia (HP:0005772)1.71006279
172Respiratory failure (HP:0002878)1.70612703
173Abnormality of glycolipid metabolism (HP:0010969)1.70414689
174Abnormality of glycosphingolipid metabolism (HP:0004343)1.70414689
175Delayed gross motor development (HP:0002194)1.70004289
176Breast carcinoma (HP:0003002)1.68399642
177Increased serum lactate (HP:0002151)1.68250623
178Aplasia/hypoplasia of the uterus (HP:0008684)1.68241352
179Chorioretinal atrophy (HP:0000533)1.68095347
180Hematochezia (HP:0002573)1.67908372
181Increased corneal curvature (HP:0100692)1.67353485
182Keratoconus (HP:0000563)1.67353485
183Inability to walk (HP:0002540)1.66156033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.53306462
2PASK3.83883580
3IRAK33.65250598
4FRK3.57115707
5MAP4K23.19750575
6ERN13.16413466
7TAOK33.10062840
8TRIM283.08817744
9MAPK153.00408529
10BCKDK2.88469079
11MAP3K122.84613831
12MAP3K22.59108159
13HIPK22.35047977
14WNK42.24931158
15NME22.17549717
16IRAK22.02252742
17EIF2AK32.01235160
18CASK1.89984515
19FLT31.86918074
20CAMKK21.82183389
21MAP3K41.81557359
22NTRK11.79264765
23GRK11.74253909
24PLK21.72075805
25IRAK11.69888615
26SIK31.66983162
27MET1.53421331
28NME11.48539376
29NUAK11.48167395
30SCYL21.48101470
31MST41.46596439
32CSNK1G11.45749373
33TNIK1.43593888
34MAP2K71.42038440
35SRPK11.41583076
36PBK1.39475453
37CSNK1A1L1.38966780
38PINK11.35780172
39CSNK1G31.33375502
40CSNK1G21.29983752
41TXK1.29765416
42IRAK41.25778012
43MAP3K11.21848406
44MAP2K21.21683872
45DYRK31.18820668
46STK31.16341650
47PIK3CG1.15343330
48MKNK21.15070159
49MAP3K111.14066566
50EIF2AK11.12896276
51MST1R1.11901047
52WNK31.09146530
53MYLK1.08215838
54ABL21.01727438
55DYRK1B1.01546519
56STK241.01525232
57PDGFRA0.98873238
58TESK10.94521547
59NEK90.93530168
60MKNK10.93096126
61NTRK30.93061955
62AKT30.92724821
63PAK30.92624827
64PIM20.91907264
65BMPR20.91265439
66PRKD30.90994467
67ACVR1B0.90877403
68BMPR1B0.89898751
69MAPK130.88760825
70CAMKK10.88736501
71BCR0.87904486
72LIMK10.87381052
73TRPM70.87076052
74ZAK0.85693342
75ARAF0.85297889
76BRAF0.84678378
77NEK10.84057796
78RIPK40.84035745
79CDC42BPA0.82383475
80UHMK10.82169014
81CAMK2D0.80146192
82TRIB30.79944103
83BRSK20.78487839
84EPHA30.77491350
85TIE10.76929901
86RPS6KA40.76706441
87PLK30.76690673
88JAK20.75505409
89TEC0.74770732
90CCNB10.73941177
91MAP3K30.72932749
92PRKCE0.70840334
93PTK20.69668749
94CAMK2B0.68861695
95STK390.68482082
96ERBB40.65004332
97PRKCI0.64885628
98MAPKAPK50.62387619
99PDK20.61034052
100DYRK1A0.59150897
101EIF2AK20.58115462
102KSR20.58030853
103PRKCH0.56863375
104MAP2K10.55702563
105CDK190.53816461
106NEK60.53793643
107ERBB30.53048852
108BRD40.52923042
109GSK3A0.52720711
110VRK10.51935351
111PTK60.50080620
112CDK30.49873546
113MARK10.49646707
114FER0.49645020
115DYRK20.48477473
116BLK0.47657387
117MAP3K140.45987088
118ADRBK20.45371846
119FGFR20.43890003
120CAMK2G0.43785235
121DAPK10.42376512
122CHUK0.41525355
123PRKCG0.41317986
124ABL10.41035606
125EPHA40.40726058
126PRKACG0.40662758
127CSNK1A10.40057092
128EGFR0.39662074
129OXSR10.39280639
130TGFBR20.39184654
131JAK10.38926130
132JAK30.37334369
133IKBKB0.36544808
134TLK10.35894937
135PIK3CA0.35848509
136GRK70.34793541
137TGFBR10.34487840
138TBK10.34211017
139RET0.33184073
140PRKCD0.32913135
141LATS10.32588922
142STK38L0.32196501
143TAF10.31277400
144IGF1R0.31247009
145NLK0.29946626
146RPS6KB10.28737626
147TSSK60.28269429
148PRKACA0.28252216
149CAMK2A0.26957989
150ZAP700.26074655
151PRKD10.25153727
152PHKG10.24798669
153PHKG20.24798669
154PRKACB0.24716392
155PRKCA0.23989476
156MAP3K50.23610558
157ADRBK10.23439616
158STK160.22843964
159WNK10.21914275
160PDGFRB0.21898353

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.77063868
2Protein export_Homo sapiens_hsa030606.95761943
3Sulfur metabolism_Homo sapiens_hsa009204.66172238
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.21936219
5Basal transcription factors_Homo sapiens_hsa030222.33433977
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28070391
7Vibrio cholerae infection_Homo sapiens_hsa051102.16880725
8Phototransduction_Homo sapiens_hsa047442.01918293
9Non-homologous end-joining_Homo sapiens_hsa034501.97326327
10Insulin secretion_Homo sapiens_hsa049111.82188121
11Folate biosynthesis_Homo sapiens_hsa007901.79808377
12Type I diabetes mellitus_Homo sapiens_hsa049401.76458139
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68263496
14N-Glycan biosynthesis_Homo sapiens_hsa005101.65959332
15Selenocompound metabolism_Homo sapiens_hsa004501.64458584
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.62775021
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58198530
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58174777
19RNA polymerase_Homo sapiens_hsa030201.55721439
20RNA degradation_Homo sapiens_hsa030181.55142482
21Lysosome_Homo sapiens_hsa041421.52395617
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52332543
23Tryptophan metabolism_Homo sapiens_hsa003801.45242040
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42547988
25Asthma_Homo sapiens_hsa053101.34595098
26Pancreatic secretion_Homo sapiens_hsa049721.33712830
27Butanoate metabolism_Homo sapiens_hsa006501.30475033
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29566925
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28375110
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22434161
31Fat digestion and absorption_Homo sapiens_hsa049751.22239166
32Type II diabetes mellitus_Homo sapiens_hsa049301.21767667
33Nucleotide excision repair_Homo sapiens_hsa034201.18853859
34Other glycan degradation_Homo sapiens_hsa005111.16219506
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.14489233
36Histidine metabolism_Homo sapiens_hsa003401.13586735
37Oxidative phosphorylation_Homo sapiens_hsa001901.12931284
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11556295
39Collecting duct acid secretion_Homo sapiens_hsa049661.04493667
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.04434375
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.04234470
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03964585
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03283675
44Peroxisome_Homo sapiens_hsa041460.98385483
45Starch and sucrose metabolism_Homo sapiens_hsa005000.97757217
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.97353759
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95780366
48Phenylalanine metabolism_Homo sapiens_hsa003600.93365182
49RNA transport_Homo sapiens_hsa030130.87708089
50Steroid biosynthesis_Homo sapiens_hsa001000.87064535
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85082223
52Regulation of autophagy_Homo sapiens_hsa041400.83534202
53Fanconi anemia pathway_Homo sapiens_hsa034600.82721486
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.82240963
55Cocaine addiction_Homo sapiens_hsa050300.81750195
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81371610
57Retinol metabolism_Homo sapiens_hsa008300.79479275
58Fatty acid degradation_Homo sapiens_hsa000710.78840948
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78407856
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78243839
61Tyrosine metabolism_Homo sapiens_hsa003500.78060432
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77837560
63Linoleic acid metabolism_Homo sapiens_hsa005910.76294060
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76280645
65Prion diseases_Homo sapiens_hsa050200.74980570
66GABAergic synapse_Homo sapiens_hsa047270.73844271
67Legionellosis_Homo sapiens_hsa051340.73693646
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71638312
69Mineral absorption_Homo sapiens_hsa049780.70902489
70Spliceosome_Homo sapiens_hsa030400.70058282
71Thyroid hormone synthesis_Homo sapiens_hsa049180.70018413
72Phagosome_Homo sapiens_hsa041450.69800607
73Alzheimers disease_Homo sapiens_hsa050100.69055603
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67953042
75Protein digestion and absorption_Homo sapiens_hsa049740.66919572
76Nicotine addiction_Homo sapiens_hsa050330.66498667
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66336749
78Purine metabolism_Homo sapiens_hsa002300.65821981
79Allograft rejection_Homo sapiens_hsa053300.65564487
80Homologous recombination_Homo sapiens_hsa034400.63035451
81Fatty acid elongation_Homo sapiens_hsa000620.61533120
82Insulin resistance_Homo sapiens_hsa049310.61323447
83p53 signaling pathway_Homo sapiens_hsa041150.61021540
84Galactose metabolism_Homo sapiens_hsa000520.60970598
85Mismatch repair_Homo sapiens_hsa034300.60912841
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.60232282
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58248982
88Propanoate metabolism_Homo sapiens_hsa006400.57317148
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57232097
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56262538
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53383828
92Parkinsons disease_Homo sapiens_hsa050120.51873871
93Arginine and proline metabolism_Homo sapiens_hsa003300.51052058
94Sphingolipid metabolism_Homo sapiens_hsa006000.50954844
95Autoimmune thyroid disease_Homo sapiens_hsa053200.50328941
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49886450
97Rheumatoid arthritis_Homo sapiens_hsa053230.48640153
98Sulfur relay system_Homo sapiens_hsa041220.47194653
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46718831
100Prolactin signaling pathway_Homo sapiens_hsa049170.45032840
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43565403
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42998026
103Complement and coagulation cascades_Homo sapiens_hsa046100.41789510
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41786481
105Circadian rhythm_Homo sapiens_hsa047100.40923039
106Graft-versus-host disease_Homo sapiens_hsa053320.40851228
107Nitrogen metabolism_Homo sapiens_hsa009100.40437162
108Metabolic pathways_Homo sapiens_hsa011000.39390263
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39241917
110TGF-beta signaling pathway_Homo sapiens_hsa043500.39035957
111Morphine addiction_Homo sapiens_hsa050320.38984790
112Amphetamine addiction_Homo sapiens_hsa050310.36574713
113Fatty acid metabolism_Homo sapiens_hsa012120.35692817
114Serotonergic synapse_Homo sapiens_hsa047260.35468744
115Arginine biosynthesis_Homo sapiens_hsa002200.35227909
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35088214
117beta-Alanine metabolism_Homo sapiens_hsa004100.34524336
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34345925
119Synaptic vesicle cycle_Homo sapiens_hsa047210.33999491
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33921357
121Renin-angiotensin system_Homo sapiens_hsa046140.32741598
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32174160
123Glucagon signaling pathway_Homo sapiens_hsa049220.31980065
124Chemical carcinogenesis_Homo sapiens_hsa052040.31828996
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31055597
126mRNA surveillance pathway_Homo sapiens_hsa030150.30907216
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30736395
128Pyrimidine metabolism_Homo sapiens_hsa002400.30472949
129Antigen processing and presentation_Homo sapiens_hsa046120.25864247
130ABC transporters_Homo sapiens_hsa020100.25798871
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24759966
132Glutathione metabolism_Homo sapiens_hsa004800.24338601
133Proteasome_Homo sapiens_hsa030500.23857724
134Pertussis_Homo sapiens_hsa051330.23807386
135Arachidonic acid metabolism_Homo sapiens_hsa005900.23734821
136Primary immunodeficiency_Homo sapiens_hsa053400.22989588
137Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21946510
138Taste transduction_Homo sapiens_hsa047420.20788279
139Ether lipid metabolism_Homo sapiens_hsa005650.20339570
140Caffeine metabolism_Homo sapiens_hsa002320.20229540
141Vitamin digestion and absorption_Homo sapiens_hsa049770.19835572
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19118995
143Dopaminergic synapse_Homo sapiens_hsa047280.18253781
144Pyruvate metabolism_Homo sapiens_hsa006200.17603899
145Huntingtons disease_Homo sapiens_hsa050160.17227480
146Tuberculosis_Homo sapiens_hsa051520.16503526

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