UFSP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)7.85814138
2neurotransmitter catabolic process (GO:0042135)6.79031277
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.73291087
4positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.34978447
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.33243297
6ATP synthesis coupled proton transport (GO:0015986)5.33243297
7negative regulation of B cell apoptotic process (GO:0002903)4.98358766
8proline biosynthetic process (GO:0006561)4.95256958
9DNA strand renaturation (GO:0000733)4.90987968
10rRNA methylation (GO:0031167)4.89731150
11phenol-containing compound catabolic process (GO:0019336)4.70603825
12rRNA modification (GO:0000154)4.70564831
13peptidyl-arginine omega-N-methylation (GO:0035247)4.43544296
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.39811330
15negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.30022188
16behavioral response to nicotine (GO:0035095)4.25618994
17negative regulation of microtubule polymerization (GO:0031115)4.15377672
18respiratory electron transport chain (GO:0022904)4.14541196
19electron transport chain (GO:0022900)4.12867749
20synaptic transmission, cholinergic (GO:0007271)4.10203357
21oxygen transport (GO:0015671)3.95500985
22regulation of translational fidelity (GO:0006450)3.94132085
23folic acid metabolic process (GO:0046655)3.93711641
24protein insertion into membrane (GO:0051205)3.92257348
25adenosine receptor signaling pathway (GO:0001973)3.89578786
26cellular response to ATP (GO:0071318)3.83117221
27ribosomal small subunit biogenesis (GO:0042274)3.79850104
28regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.69364306
29regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.69364306
30pseudouridine synthesis (GO:0001522)3.69112509
31regulation of mammary gland epithelial cell proliferation (GO:0033599)3.65601139
32neuron cell-cell adhesion (GO:0007158)3.62428199
33regulation of synaptic transmission, dopaminergic (GO:0032225)3.62332578
34neurotransmitter biosynthetic process (GO:0042136)3.61487716
35proline transport (GO:0015824)3.58767685
36ribosome biogenesis (GO:0042254)3.57901725
37pentose metabolic process (GO:0019321)3.57519579
38behavioral response to ethanol (GO:0048149)3.56806566
39histone arginine methylation (GO:0034969)3.56551792
40UV protection (GO:0009650)3.55846572
41peptidyl-arginine N-methylation (GO:0035246)3.50114956
42peptidyl-arginine methylation (GO:0018216)3.50114956
43mitotic nuclear envelope reassembly (GO:0007084)3.48531108
44nuclear envelope reassembly (GO:0031468)3.48531108
45rRNA transcription (GO:0009303)3.48128413
46catecholamine transport (GO:0051937)3.47880330
47synaptic vesicle exocytosis (GO:0016079)3.47808567
48nucleotide-sugar biosynthetic process (GO:0009226)3.47528681
49neurotransmitter metabolic process (GO:0042133)3.47202242
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.46258355
51neurotransmitter secretion (GO:0007269)3.45480181
52vocalization behavior (GO:0071625)3.45452505
53positive regulation of guanylate cyclase activity (GO:0031284)3.42285412
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42051077
55tRNA modification (GO:0006400)3.41896419
56porphyrin-containing compound biosynthetic process (GO:0006779)3.41863945
57inner mitochondrial membrane organization (GO:0007007)3.39006455
58peptidyl-histidine modification (GO:0018202)3.38883454
59UTP biosynthetic process (GO:0006228)3.37505097
60mannose metabolic process (GO:0006013)3.34857245
61negative regulation of cell aging (GO:0090344)3.34809907
62base-excision repair, AP site formation (GO:0006285)3.33286690
63proline metabolic process (GO:0006560)3.33257423
64synaptic transmission, dopaminergic (GO:0001963)3.33042596
65oxidative phosphorylation (GO:0006119)3.30119417
66metallo-sulfur cluster assembly (GO:0031163)3.29397224
67iron-sulfur cluster assembly (GO:0016226)3.29397224
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24464311
69positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.24441140
70establishment of protein localization to mitochondrial membrane (GO:0090151)3.24136146
71cell migration in hindbrain (GO:0021535)3.23369950
72chaperone-mediated protein transport (GO:0072321)3.22734207
73DNA replication checkpoint (GO:0000076)3.21742097
74negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.21684639
75regulation of guanylate cyclase activity (GO:0031282)3.21677093
76pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.21544037
77guanosine-containing compound biosynthetic process (GO:1901070)3.21119430
78ATP biosynthetic process (GO:0006754)3.20717720
79mitochondrial DNA metabolic process (GO:0032042)3.20567764
80nucleotide salvage (GO:0043173)3.17902460
81regulation of short-term neuronal synaptic plasticity (GO:0048172)3.17885113
82heme biosynthetic process (GO:0006783)3.17866795
83regulation of rhodopsin mediated signaling pathway (GO:0022400)3.16698422
84protoporphyrinogen IX metabolic process (GO:0046501)3.16607291
85neurotransmitter transport (GO:0006836)3.15748573
86positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.15022392
87ribonucleoprotein complex biogenesis (GO:0022613)3.14783359
88neuronal action potential propagation (GO:0019227)3.14610912
89neuron recognition (GO:0008038)3.14601256
90protein complex biogenesis (GO:0070271)3.12798725
91regulation of catecholamine metabolic process (GO:0042069)3.12604717
92regulation of dopamine metabolic process (GO:0042053)3.12604717
93regulation of neurotransmitter levels (GO:0001505)3.12017474
94GTP biosynthetic process (GO:0006183)3.09497324
95pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.08107952
96succinate metabolic process (GO:0006105)3.05877111
97response to histamine (GO:0034776)3.05402858
98rhodopsin mediated signaling pathway (GO:0016056)3.04488519
99L-serine metabolic process (GO:0006563)3.04049005
100catechol-containing compound biosynthetic process (GO:0009713)3.03984449
101catecholamine biosynthetic process (GO:0042423)3.03984449
102muscle cell fate commitment (GO:0042693)3.03908763
103amyloid precursor protein catabolic process (GO:0042987)3.01899436
104regulation of B cell apoptotic process (GO:0002902)3.01648333
105tetrapyrrole biosynthetic process (GO:0033014)3.01619203
106CTP biosynthetic process (GO:0006241)3.00834959
107CTP metabolic process (GO:0046036)3.00834959
108calcium-mediated signaling using intracellular calcium source (GO:0035584)3.00701795
109behavioral response to cocaine (GO:0048148)2.99195700
110protoporphyrinogen IX biosynthetic process (GO:0006782)2.99066210
111alkaloid metabolic process (GO:0009820)2.98623892
112ATP hydrolysis coupled proton transport (GO:0015991)2.97224643
113energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.97224643
114mitochondrial respiratory chain complex assembly (GO:0033108)2.96926723
115peptidyl-cysteine modification (GO:0018198)2.96178194
116pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.95664235
117gas transport (GO:0015669)2.95604436
118UMP biosynthetic process (GO:0006222)2.94295430
119pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.94295430
120UMP metabolic process (GO:0046049)2.94295430
121pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.94295430
122tRNA methylation (GO:0030488)2.93877063
123sulfur amino acid catabolic process (GO:0000098)2.93327300
124neuromuscular synaptic transmission (GO:0007274)2.93313755
125neuromuscular process controlling posture (GO:0050884)2.92006060
126protein maturation by protein folding (GO:0022417)2.90968335
127purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.90702554
128hydrogen ion transmembrane transport (GO:1902600)2.90633166
129UTP metabolic process (GO:0046051)2.90602225
130response to insecticide (GO:0017085)2.88859266
131regulation of skeletal muscle contraction (GO:0014819)2.88533100
132snRNA metabolic process (GO:0016073)2.88437676
133dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.88319257
134pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.87824083
135axonal fasciculation (GO:0007413)2.86919788
136retinal cone cell development (GO:0046549)2.86674037
137response to methylmercury (GO:0051597)2.86353430
138mRNA cleavage (GO:0006379)2.85702933
139regulation of neurotransmitter uptake (GO:0051580)2.85650196
140dopamine metabolic process (GO:0042417)2.85300676
141pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.83805932
142purine nucleoside triphosphate biosynthetic process (GO:0009145)2.82928361
143pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.81334743
144NADH dehydrogenase complex assembly (GO:0010257)2.80773093
145mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80773093
146mitochondrial respiratory chain complex I assembly (GO:0032981)2.80773093
147sympathetic nervous system development (GO:0048485)2.79340257
148G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.78992540
149positive regulation of neurotransmitter transport (GO:0051590)2.78875919
150short-term memory (GO:0007614)2.78716767
151mating behavior (GO:0007617)2.78306861
152mitotic cell cycle arrest (GO:0071850)2.78238671
153deoxyribonucleotide catabolic process (GO:0009264)2.76802363
154respiratory system process (GO:0003016)2.76014793
155positive regulation of interleukin-17 production (GO:0032740)2.75423916
156rRNA processing (GO:0006364)2.75020657
157deoxyribose phosphate catabolic process (GO:0046386)2.74719006
158dopamine biosynthetic process (GO:0042416)2.73348565
159striatum development (GO:0021756)2.73332737
160protein retention in ER lumen (GO:0006621)2.73314134
161pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.72332772
162response to parathyroid hormone (GO:0071107)2.71398598
163kinetochore assembly (GO:0051382)2.71153499
164RNA methylation (GO:0001510)2.70936803
165misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.69908298
166cellular component biogenesis (GO:0044085)2.69356896
167pyrimidine nucleotide catabolic process (GO:0006244)2.68060364
168nucleoside salvage (GO:0043174)2.67535380
169nucleobase-containing small molecule interconversion (GO:0015949)2.67476584
170purine deoxyribonucleotide catabolic process (GO:0009155)2.66470707
171nucleoside transmembrane transport (GO:1901642)2.64223787
172pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.63970312
173base-excision repair (GO:0006284)2.63391475
174synaptic vesicle maturation (GO:0016188)2.62514286
175protein carboxylation (GO:0018214)2.59847434
176peptidyl-glutamic acid carboxylation (GO:0017187)2.59847434
177regulation of oxidative phosphorylation (GO:0002082)2.59008019
178growth hormone secretion (GO:0030252)2.58369636
179mitochondrial fusion (GO:0008053)2.58368175
180purine ribonucleotide transport (GO:0015868)2.57600974
181adenine nucleotide transport (GO:0051503)2.57299091
182regulation of protein kinase A signaling (GO:0010738)2.56962674
183ribonucleoside triphosphate biosynthetic process (GO:0009201)2.56086674
184social behavior (GO:0035176)2.55613054
185intraspecies interaction between organisms (GO:0051703)2.55613054
186rRNA metabolic process (GO:0016072)2.55600501
187protein targeting to mitochondrion (GO:0006626)2.55146087
188establishment of protein localization to mitochondrion (GO:0072655)2.54962395
189mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.54468997
190RNA modification (GO:0009451)2.54374871
191respiratory chain complex IV assembly (GO:0008535)2.54113439
192positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.52971124
193regulation of voltage-gated calcium channel activity (GO:1901385)2.52231583
194regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51520780
195protein localization to synapse (GO:0035418)2.50391046
196chemosensory behavior (GO:0007635)2.49657468
197regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.48744273
198dopamine transport (GO:0015872)2.48012005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.36342673
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.09344361
3* VDR_21846776_ChIP-Seq_THP-1_Human3.06345113
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.90324176
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80219823
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78633057
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75371986
8ERG_21242973_ChIP-ChIP_JURKAT_Human2.72347386
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68403126
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62963805
11* XRN2_22483619_ChIP-Seq_HELA_Human2.54950355
12ZNF263_19887448_ChIP-Seq_K562_Human2.54151316
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.50324034
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50202561
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.46729111
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38386894
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38298669
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.37288943
19REST_21632747_ChIP-Seq_MESCs_Mouse2.30971560
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30159926
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29653960
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29653960
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.26977244
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26108919
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25125400
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24654501
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24533308
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16763941
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15774167
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09292648
31REST_18959480_ChIP-ChIP_MESCs_Mouse2.05963383
32GBX2_23144817_ChIP-Seq_PC3_Human2.05058707
33* MYC_22102868_ChIP-Seq_BL_Human2.02041332
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.00538888
35ZNF274_21170338_ChIP-Seq_K562_Hela1.93201867
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.92645390
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90955708
38RACK7_27058665_Chip-Seq_MCF-7_Human1.90270022
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.88312362
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.86879176
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.83248163
42E2F7_22180533_ChIP-Seq_HELA_Human1.82434965
43DCP1A_22483619_ChIP-Seq_HELA_Human1.80508841
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80421490
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80165702
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74009228
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73953352
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72382440
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.69168030
50GABP_19822575_ChIP-Seq_HepG2_Human1.67917917
51MAF_26560356_Chip-Seq_TH2_Human1.61981332
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.61293548
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60682409
54VDR_22108803_ChIP-Seq_LS180_Human1.59347269
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58895732
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58491843
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56691043
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55500340
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54446794
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54148609
61AR_21572438_ChIP-Seq_LNCaP_Human1.53570478
62DROSHA_22980978_ChIP-Seq_HELA_Human1.53227565
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52057308
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52050371
65CTCF_27219007_Chip-Seq_Bcells_Human1.51846045
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51541192
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.50306270
68* FOXP1_21924763_ChIP-Seq_HESCs_Human1.48289634
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48216399
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.47398464
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.45614779
72BCOR_27268052_Chip-Seq_Bcells_Human1.45471303
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44790835
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44674737
75MAF_26560356_Chip-Seq_TH1_Human1.44633100
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.44358422
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44137308
78* BCL6_27268052_Chip-Seq_Bcells_Human1.42996483
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.42633450
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41146601
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39995739
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39639561
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.39081993
84CTCF_21964334_Chip-Seq_Bcells_Human1.38646784
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36370692
86* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36091513
87CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35403154
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34150790
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34111704
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.32969518
91* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32487601
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32479117
93E2F1_20622854_ChIP-Seq_HELA_Human1.31524188
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30865012
95TTF2_22483619_ChIP-Seq_HELA_Human1.30839567
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29237895
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29104013
98PHF8_20622854_ChIP-Seq_HELA_Human1.28728651
99* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27669625
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27481115
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27176495
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27084935
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.26814757
104ATF3_27146783_Chip-Seq_COLON_Human1.26274622
105VDR_24763502_ChIP-Seq_THP-1_Human1.26147484
106CIITA_25753668_ChIP-Seq_RAJI_Human1.25672406
107GABP_17652178_ChIP-ChIP_JURKAT_Human1.25325372
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24507405
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24000208
110RARB_24833708_ChIP-Seq_LIVER_Mouse1.23198666
111KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23198615
112KDM5A_27292631_Chip-Seq_BREAST_Human1.22946814
113* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22709849
114RARA_24833708_ChIP-Seq_LIVER_Mouse1.22120231
115CTCF_26484167_Chip-Seq_Bcells_Mouse1.21730440
116SRF_21415370_ChIP-Seq_HL-1_Mouse1.20934351
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20801574
118KDM2B_26808549_Chip-Seq_DND41_Human1.19347902
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17945748
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15969769
121* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15904545
122* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15837202
123KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13905846
124IGF1R_20145208_ChIP-Seq_DFB_Human1.13412497
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13123771
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13054317
127UTX_26944678_Chip-Seq_JUKART_Human1.12388814
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12336264
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11677872
130SA1_27219007_Chip-Seq_ERYTHROID_Human1.09327967
131LXR_22292898_ChIP-Seq_THP-1_Human1.07418733
132TAF15_26573619_Chip-Seq_HEK293_Human1.06696533
133ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03769224
134THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03046086
135* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02806844
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01735694
137SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01197120
138MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00918685
139ETS1_20019798_ChIP-Seq_JURKAT_Human0.97465357
140ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96847817
141RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96583346
142OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95821233
143RING1B_27294783_Chip-Seq_NPCs_Mouse0.95549141
144EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94801211
145GATA1_22025678_ChIP-Seq_K562_Human0.94382219
146ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93398058
147TET1_21490601_ChIP-Seq_MESCs_Mouse0.90761106
148PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90338495
149SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89473589
150TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89443111
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.89401190
152SMC4_20622854_ChIP-Seq_HELA_Human0.89294294
153CREB1_26743006_Chip-Seq_LNCaP_Human0.89258448
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89133014
155CTCF_20526341_ChIP-Seq_ESCs_Human0.88355711
156SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87791915
157CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87043910
158RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86992354
159TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86108459
160CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85816740
161HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.85702208
162SA1_27219007_Chip-Seq_Bcells_Human0.83738757
163THAP11_20581084_ChIP-Seq_MESCs_Mouse0.83219358
164BCAT_22108803_ChIP-Seq_LS180_Human0.81416755
165TP63_17297297_ChIP-ChIP_HaCaT_Human0.81161376
166GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80249752
167TP63_22573176_ChIP-Seq_HFKS_Human0.79942958
168TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78064959
169CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77707843
170JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.77457624
171KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76044632
172KDM2B_26808549_Chip-Seq_K562_Human0.75059671
173CBX2_27304074_Chip-Seq_ESCs_Mouse0.74344460
174TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.74343377
175EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72898296
176P68_20966046_ChIP-Seq_HELA_Human0.72680208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.30730281
2MP0002822_catalepsy3.82559647
3MP0005171_absent_coat_pigmentation3.44936339
4MP0005423_abnormal_somatic_nervous3.14203490
5MP0003693_abnormal_embryo_hatching3.13153818
6MP0001348_abnormal_lacrimal_gland2.97870944
7MP0001529_abnormal_vocalization2.91736420
8MP0005645_abnormal_hypothalamus_physiol2.85936629
9MP0003111_abnormal_nucleus_morphology2.78220492
10MP0002638_abnormal_pupillary_reflex2.73118011
11MP0001661_extended_life_span2.72324277
12MP0004859_abnormal_synaptic_plasticity2.65719504
13MP0001501_abnormal_sleep_pattern2.62849319
14MP0010030_abnormal_orbit_morphology2.56204217
15MP0005058_abnormal_lysosome_morphology2.51397086
16MP0000678_abnormal_parathyroid_gland2.46742089
17MP0006276_abnormal_autonomic_nervous2.45910912
18MP0004270_analgesia2.45498849
19MP0002876_abnormal_thyroid_physiology2.39066594
20MP0003880_abnormal_central_pattern2.35476217
21MP0004957_abnormal_blastocyst_morpholog2.34035023
22MP0003635_abnormal_synaptic_transmissio2.32640641
23MP0010094_abnormal_chromosome_stability2.31675158
24MP0003705_abnormal_hypodermis_morpholog2.27980571
25MP0002837_dystrophic_cardiac_calcinosis2.27897618
26MP0002734_abnormal_mechanical_nocicepti2.22355156
27MP0005451_abnormal_body_composition2.18673231
28MP0000751_myopathy2.17639685
29MP0005174_abnormal_tail_pigmentation2.16359653
30MP0003656_abnormal_erythrocyte_physiolo2.11856676
31MP0009745_abnormal_behavioral_response2.11207367
32MP0009333_abnormal_splenocyte_physiolog2.08645945
33MP0002735_abnormal_chemical_nociception2.07543800
34MP0002733_abnormal_thermal_nociception2.06962688
35MP0001905_abnormal_dopamine_level2.05493116
36MP0003077_abnormal_cell_cycle2.01041899
37MP0002249_abnormal_larynx_morphology1.99500571
38MP0002272_abnormal_nervous_system1.98093519
39MP0001440_abnormal_grooming_behavior1.98064396
40MP0003879_abnormal_hair_cell1.97149728
41MP0001188_hyperpigmentation1.96418892
42MP0009046_muscle_twitch1.95608159
43MP0003329_amyloid_beta_deposits1.94797551
44MP0005076_abnormal_cell_differentiation1.94403094
45MP0002064_seizures1.91335700
46MP0004858_abnormal_nervous_system1.89798232
47MP0010386_abnormal_urinary_bladder1.89739199
48MP0003806_abnormal_nucleotide_metabolis1.87355455
49MP0002063_abnormal_learning/memory/cond1.84609888
50MP0001853_heart_inflammation1.83247193
51MP0009840_abnormal_foam_cell1.82500929
52MP0003453_abnormal_keratinocyte_physiol1.81035248
53MP0008932_abnormal_embryonic_tissue1.80142169
54MP0004185_abnormal_adipocyte_glucose1.79165369
55MP0005551_abnormal_eye_electrophysiolog1.76447154
56MP0004147_increased_porphyrin_level1.73925310
57MP0005501_abnormal_skin_physiology1.73512555
58MP0001346_abnormal_lacrimal_gland1.70306960
59MP0001970_abnormal_pain_threshold1.70187026
60MP0003786_premature_aging1.67220919
61MP0000003_abnormal_adipose_tissue1.67067793
62MP0002572_abnormal_emotion/affect_behav1.66894030
63MP0005083_abnormal_biliary_tract1.64524475
64MP0001968_abnormal_touch/_nociception1.60258871
65MP0004142_abnormal_muscle_tone1.59657373
66MP0003136_yellow_coat_color1.57890683
67MP0000015_abnormal_ear_pigmentation1.57478410
68MP0004145_abnormal_muscle_electrophysio1.55109205
69MP0002160_abnormal_reproductive_system1.53971173
70MP0008872_abnormal_physiological_respon1.53184226
71MP0000538_abnormal_urinary_bladder1.52376690
72MP0003122_maternal_imprinting1.51536628
73MP0002909_abnormal_adrenal_gland1.49332693
74MP0002184_abnormal_innervation1.48034509
75MP0002332_abnormal_exercise_endurance1.47465232
76MP0000013_abnormal_adipose_tissue1.46069188
77MP0009278_abnormal_bone_marrow1.44598096
78MP0003646_muscle_fatigue1.42042333
79MP0001873_stomach_inflammation1.41093424
80MP0000358_abnormal_cell_content/1.40473484
81MP0000747_muscle_weakness1.39397550
82MP0002736_abnormal_nociception_after1.37985913
83MP0008260_abnormal_autophagy1.37223688
84MP0004215_abnormal_myocardial_fiber1.33545559
85MP0000749_muscle_degeneration1.32065943
86MP0004924_abnormal_behavior1.29450718
87MP0005386_behavior/neurological_phenoty1.29450718
88MP0008058_abnormal_DNA_repair1.26333145
89MP0009379_abnormal_foot_pigmentation1.26240017
90MP0005310_abnormal_salivary_gland1.22601731
91MP0006072_abnormal_retinal_apoptosis1.22055927
92MP0008569_lethality_at_weaning1.21902253
93MP0001986_abnormal_taste_sensitivity1.20141568
94MP0003300_gastrointestinal_ulcer1.19746100
95MP0000313_abnormal_cell_death1.19262543
96MP0008875_abnormal_xenobiotic_pharmacok1.18587070
97MP0002067_abnormal_sensory_capabilities1.18102619
98MP0005332_abnormal_amino_acid1.17589112
99MP0005620_abnormal_muscle_contractility1.17570766
100MP0002751_abnormal_autonomic_nervous1.17471299
101MP0003123_paternal_imprinting1.15586562
102MP0000604_amyloidosis1.12168993
103MP0008775_abnormal_heart_ventricle1.11104280
104MP0002019_abnormal_tumor_incidence1.09930979
105MP0004233_abnormal_muscle_weight1.09922259
106MP0004381_abnormal_hair_follicle1.09400256
107MP0000350_abnormal_cell_proliferation1.09050141
108MP0003011_delayed_dark_adaptation1.07775343
109MP0002106_abnormal_muscle_physiology1.06934789
110MP0002796_impaired_skin_barrier1.05601539
111MP0002557_abnormal_social/conspecific_i1.05211034
112MP0000465_gastrointestinal_hemorrhage1.05180572
113MP0002882_abnormal_neuron_morphology1.04357665
114MP0008789_abnormal_olfactory_epithelium1.02583143
115MP0004043_abnormal_pH_regulation1.01697925
116MP0004036_abnormal_muscle_relaxation1.01547469
117MP0009931_abnormal_skin_appearance1.01517778
118MP0002066_abnormal_motor_capabilities/c1.00962516
119MP0005623_abnormal_meninges_morphology1.00439288
120MP0001756_abnormal_urination1.00055917
121MP0001919_abnormal_reproductive_system0.99600257
122MP0003959_abnormal_lean_body0.99011629
123MP0004811_abnormal_neuron_physiology0.97896612
124MP0005409_darkened_coat_color0.95714598
125MP0005375_adipose_tissue_phenotype0.94793679
126MP0005253_abnormal_eye_physiology0.92794140
127MP0006035_abnormal_mitochondrial_morpho0.92649322
128MP0002234_abnormal_pharynx_morphology0.91963002
129MP0000750_abnormal_muscle_regeneration0.91762169
130MP0003638_abnormal_response/metabolism_0.91704818
131MP0005330_cardiomyopathy0.91569698
132MP0002269_muscular_atrophy0.90450944
133MP0002080_prenatal_lethality0.89387902
134MP0000049_abnormal_middle_ear0.88914687
135MP0000681_abnormal_thyroid_gland0.88705155
136MP0001502_abnormal_circadian_rhythm0.87849436
137MP0002877_abnormal_melanocyte_morpholog0.87273009
138MP0006036_abnormal_mitochondrial_physio0.87247862
139MP0002229_neurodegeneration0.86842248
140MP0002752_abnormal_somatic_nervous0.86553684
141MP0003315_abnormal_perineum_morphology0.86510871
142MP0000858_altered_metastatic_potential0.86501929
143MP0005535_abnormal_body_temperature0.86461180
144MP0000759_abnormal_skeletal_muscle0.86382665
145MP0004484_altered_response_of0.86047659
146MP0001984_abnormal_olfaction0.85989779
147MP0005584_abnormal_enzyme/coenzyme_acti0.83838295
148MP0000955_abnormal_spinal_cord0.83585273
149MP0000733_abnormal_muscle_development0.83280915
150MP0005369_muscle_phenotype0.83112176
151MP0008007_abnormal_cellular_replicative0.80786230
152MP0005499_abnormal_olfactory_system0.80681411
153MP0005394_taste/olfaction_phenotype0.80681411
154MP0000778_abnormal_nervous_system0.80557660
155MP0001835_abnormal_antigen_presentation0.80362726
156MP0004084_abnormal_cardiac_muscle0.80255268
157MP0000490_abnormal_crypts_of0.79926410
158MP0002127_abnormal_cardiovascular_syste0.78596688
159MP0004085_abnormal_heartbeat0.78481570
160MP0005266_abnormal_metabolism0.77275071
161MP0001697_abnormal_embryo_size0.77057909
162MP0002069_abnormal_eating/drinking_beha0.76938791
163MP0002060_abnormal_skin_morphology0.73751414
164MP0002277_abnormal_respiratory_mucosa0.73675765
165MP0005197_abnormal_uvea_morphology0.72892168
166MP0003763_abnormal_thymus_physiology0.72125383
167MP0005666_abnormal_adipose_tissue0.72110097
168MP0001730_embryonic_growth_arrest0.72035913
169MP0004782_abnormal_surfactant_physiolog0.70990206
170MP0010771_integument_phenotype0.70446052
171MP0003448_altered_tumor_morphology0.69161371
172MP0000367_abnormal_coat/_hair0.68344805
173MP0003186_abnormal_redox_activity0.68304925
174MP0009053_abnormal_anal_canal0.66222306
175MP0005389_reproductive_system_phenotype0.64277774
176MP0001216_abnormal_epidermal_layer0.63751127
177MP0005257_abnormal_intraocular_pressure0.63717005
178MP0002089_abnormal_postnatal_growth/wei0.62390060
179MP0001849_ear_inflammation0.61785098
180MP0001672_abnormal_embryogenesis/_devel0.61728343

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.13956185
2Testicular atrophy (HP:0000029)5.01685057
3Myokymia (HP:0002411)4.48256968
4Abnormal mitochondria in muscle tissue (HP:0008316)4.18482933
5Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.10506487
6Acute necrotizing encephalopathy (HP:0006965)4.07082139
7Hypercortisolism (HP:0001578)3.99805338
8Squamous cell carcinoma (HP:0002860)3.74608446
9Poikiloderma (HP:0001029)3.74469457
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.71287935
11Progressive muscle weakness (HP:0003323)3.61113478
12Hypothermia (HP:0002045)3.60627738
13Cholelithiasis (HP:0001081)3.59608855
14Focal motor seizures (HP:0011153)3.59317683
15Ulnar bowing (HP:0003031)3.49647998
16Mitochondrial inheritance (HP:0001427)3.43077757
17Acute encephalopathy (HP:0006846)3.41461676
18Abnormal gallbladder physiology (HP:0012438)3.39052017
19Cholecystitis (HP:0001082)3.39052017
20Progressive macrocephaly (HP:0004481)3.33536758
21Rib fusion (HP:0000902)3.30148066
22Vaginal fistula (HP:0004320)3.28337939
23Renal Fanconi syndrome (HP:0001994)3.27295738
24Abnormal pupillary function (HP:0007686)3.16519663
25Abnormal gallbladder morphology (HP:0012437)3.14938716
26Pheochromocytoma (HP:0002666)3.14685619
27Limb dystonia (HP:0002451)3.12868743
28Delusions (HP:0000746)3.07752737
29Rectal fistula (HP:0100590)3.06494601
30Rectovaginal fistula (HP:0000143)3.06494601
31Hepatocellular necrosis (HP:0001404)3.05723016
32Abnormality of the intrinsic pathway (HP:0010989)3.03314051
33Focal seizures (HP:0007359)3.02845164
34Thin bony cortex (HP:0002753)3.01622355
35Exercise-induced myalgia (HP:0003738)3.01610284
36Visual hallucinations (HP:0002367)2.97635597
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.97148397
38Absence seizures (HP:0002121)2.95854697
39Intestinal fistula (HP:0100819)2.92396371
40Generalized tonic-clonic seizures (HP:0002069)2.92027273
41Increased hepatocellular lipid droplets (HP:0006565)2.91703551
42Lipid accumulation in hepatocytes (HP:0006561)2.91015950
43Reticulocytosis (HP:0001923)2.88418355
44Abnormality of calcium-phosphate metabolism (HP:0100530)2.88268362
45Poikilocytosis (HP:0004447)2.84463404
46Atonic seizures (HP:0010819)2.80158829
47Increased CSF lactate (HP:0002490)2.79533083
48Neuroendocrine neoplasm (HP:0100634)2.77063513
49Poor suck (HP:0002033)2.74711686
50Anxiety (HP:0000739)2.70398099
51Hemorrhage of the eye (HP:0011885)2.64898018
52Myotonia (HP:0002486)2.63460069
53Optic disc pallor (HP:0000543)2.62803226
54Increased intramyocellular lipid droplets (HP:0012240)2.61920679
55Myopathic facies (HP:0002058)2.61462590
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.60077838
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.60077838
58Reduced antithrombin III activity (HP:0001976)2.59956370
59Microvesicular hepatic steatosis (HP:0001414)2.57188283
60Premature graying of hair (HP:0002216)2.55632529
61Muscle stiffness (HP:0003552)2.53880298
62Abnormal trabecular bone morphology (HP:0100671)2.53853610
63Dialeptic seizures (HP:0011146)2.49460860
64Hepatic necrosis (HP:0002605)2.47337113
65Muscle hypertrophy of the lower extremities (HP:0008968)2.45245015
66Aplasia of the musculature (HP:0100854)2.44425502
67Breast hypoplasia (HP:0003187)2.44178793
68Adrenal overactivity (HP:0002717)2.42880524
69Cerebral edema (HP:0002181)2.41512930
70Amblyopia (HP:0000646)2.41241385
71Annular pancreas (HP:0001734)2.41152510
72Microretrognathia (HP:0000308)2.40327979
73Palpitations (HP:0001962)2.38334834
74Rectal prolapse (HP:0002035)2.37242744
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.34504894
76Double outlet right ventricle (HP:0001719)2.34131240
77Congenital malformation of the right heart (HP:0011723)2.34131240
78Hyperacusis (HP:0010780)2.33642410
79Dyschromatopsia (HP:0007641)2.33585046
80Exercise-induced muscle cramps (HP:0003710)2.31709792
81Absent thumb (HP:0009777)2.31551418
82Popliteal pterygium (HP:0009756)2.29908712
83Febrile seizures (HP:0002373)2.29732332
84Abnormality of the gallbladder (HP:0005264)2.29648064
85Respiratory failure (HP:0002878)2.28632801
86Rough bone trabeculation (HP:0100670)2.28383428
87Type I transferrin isoform profile (HP:0003642)2.28065103
88Emotional lability (HP:0000712)2.27920041
89Progressive external ophthalmoplegia (HP:0000590)2.26865020
90Increased muscle lipid content (HP:0009058)2.26007792
91Respiratory difficulties (HP:0002880)2.23828176
92Exercise intolerance (HP:0003546)2.23669914
93Hypoventilation (HP:0002791)2.22978048
94Hypoplastic heart (HP:0001961)2.22413739
95Aplasia/Hypoplasia of the spleen (HP:0010451)2.20563343
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.18710690
97Epileptic encephalopathy (HP:0200134)2.17030753
98Truncus arteriosus (HP:0001660)2.16895466
99Acanthocytosis (HP:0001927)2.15729173
100Hyperthyroidism (HP:0000836)2.15611076
101Calf muscle hypertrophy (HP:0008981)2.13155172
102Birth length less than 3rd percentile (HP:0003561)2.13027359
103Amniotic constriction ring (HP:0009775)2.12333656
104Abnormality of placental membranes (HP:0011409)2.12333656
105Mesangial abnormality (HP:0001966)2.12233024
106Neoplasm of the peripheral nervous system (HP:0100007)2.11632429
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10318002
108Abnormal protein N-linked glycosylation (HP:0012347)2.10318002
109Abnormal protein glycosylation (HP:0012346)2.10318002
110Abnormal glycosylation (HP:0012345)2.10318002
111Diaphragmatic weakness (HP:0009113)2.08432548
112Delayed epiphyseal ossification (HP:0002663)2.08011462
113Facial hemangioma (HP:0000329)2.07736804
114Turricephaly (HP:0000262)2.06920575
115Vertebral compression fractures (HP:0002953)2.06883418
116Failure to thrive in infancy (HP:0001531)2.06665642
117Psychosis (HP:0000709)2.06590158
118Hypertensive crisis (HP:0100735)2.06494068
119Lactic acidosis (HP:0003128)2.05790466
120Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05318485
121Myoglobinuria (HP:0002913)2.04253876
122Increased neuronal autofluorescent lipopigment (HP:0002074)2.03888742
123Asplenia (HP:0001746)2.02720235
124Brushfield spots (HP:0001088)2.01910566
125Stridor (HP:0010307)2.00925809
126Hypoparathyroidism (HP:0000829)2.00569218
127Depression (HP:0000716)1.99108146
128Abnormality of cells of the erythroid lineage (HP:0012130)1.98996087
129Akinesia (HP:0002304)1.98976879
130Preauricular pit (HP:0004467)1.98674049
131Periauricular skin pits (HP:0100277)1.98674049
132Right ventricular cardiomyopathy (HP:0011663)1.98189898
133Prolonged neonatal jaundice (HP:0006579)1.97981019
134Abnormality of glycolysis (HP:0004366)1.96155016
135Increased serum pyruvate (HP:0003542)1.96155016
136Abnormalities of placenta or umbilical cord (HP:0001194)1.92872529
137Ragged-red muscle fibers (HP:0003200)1.91133987
138Autoamputation (HP:0001218)1.90234625
139Progressive cerebellar ataxia (HP:0002073)1.90058373
140Short thumb (HP:0009778)1.89839479
141Abnormal number of erythroid precursors (HP:0012131)1.87932398
142Progressive inability to walk (HP:0002505)1.85418889
143Abnormality of the umbilical cord (HP:0010881)1.85067160
144Increased serum lactate (HP:0002151)1.84777708
145Hypergonadotropic hypogonadism (HP:0000815)1.84522183
146Exertional dyspnea (HP:0002875)1.84264763
147Abnormality of reticulocytes (HP:0004312)1.82709783
148Abnormality of pyrimidine metabolism (HP:0004353)1.82673708
149Sudden death (HP:0001699)1.82541019
150Supranuclear gaze palsy (HP:0000605)1.82298840
151Muscle fiber inclusion bodies (HP:0100299)1.81196504
152Joint stiffness (HP:0001387)1.81151535
153Abnormality of the calf musculature (HP:0001430)1.80916233
154Muscle fiber atrophy (HP:0100295)1.80358855
155Ankle clonus (HP:0011448)1.80180394
156Bulbar palsy (HP:0001283)1.79980333
157Leukodystrophy (HP:0002415)1.79967772
158Abnormality of the costochondral junction (HP:0000919)1.79515090
159Aplasia/Hypoplasia of the patella (HP:0006498)1.79180189
160Insomnia (HP:0100785)1.79161355
161Unilateral renal agenesis (HP:0000122)1.77776612
162Status epilepticus (HP:0002133)1.77749025
163Increased cerebral lipofuscin (HP:0011813)1.77302849
164Fetal akinesia sequence (HP:0001989)1.76861069
165Neonatal onset (HP:0003623)1.76851737
166Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76578519
167Increased circulating renin level (HP:0000848)1.76434981
168Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76365132
169Diminished movement (HP:0002374)1.76142089
170Abnormal social behavior (HP:0012433)1.75386097
171Impaired social interactions (HP:0000735)1.75386097
172Type I diabetes mellitus (HP:0100651)1.75371776
173Prolonged partial thromboplastin time (HP:0003645)1.75061740
174Conjunctival hamartoma (HP:0100780)1.74863835
175Bowed forearm bones (HP:0003956)1.74858508
176Bowing of the arm (HP:0006488)1.74858508
177Poor eye contact (HP:0000817)1.72577121
178EEG with generalized epileptiform discharges (HP:0011198)1.72447269
179Bony spicule pigmentary retinopathy (HP:0007737)1.72383080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME15.15042187
2SMG14.99763314
3VRK23.96450886
4TRIB33.63705657
5TESK23.52799809
6NTRK33.16646893
7STK162.84020082
8IRAK32.74895473
9TAF12.69601122
10PHKG12.62577664
11PHKG22.62577664
12GRK52.57414340
13ZAK2.50198699
14NTRK12.42794770
15GRK72.42525483
16MINK12.32897672
17MAP3K122.15855601
18MAP3K42.14315017
19SCYL22.11932003
20ERN12.09703477
21MARK12.07054890
22MAPK152.04064864
23SIK11.93342553
24MAP2K41.86530105
25PNCK1.81761434
26MAP3K91.78759875
27MAP2K31.77755965
28TESK11.73476631
29ARAF1.73050558
30PDK21.68879122
31LIMK11.65529835
32NME21.61943010
33MAP2K71.46423259
34MAPKAPK51.45450874
35PRKD31.44562430
36VRK11.43954024
37LATS21.42849482
38EEF2K1.42219472
39BCKDK1.41192338
40ADRBK11.40722644
41DAPK21.36648583
42TAOK21.35734978
43TSSK61.35072007
44NEK11.31719741
45NTRK21.30865260
46IRAK21.29805438
47MST1R1.29612082
48MAPK111.27834209
49KSR21.27342896
50UHMK11.25173460
51CAMK2G1.21586377
52CAMK2A1.21100220
53PRKCI1.20674740
54OBSCN1.18833500
55MAP2K11.15010170
56CASK1.14989360
57CHEK21.14804981
58PAK41.14424103
59DYRK31.13142746
60CDK141.12970602
61PLK21.08959354
62CDK191.08951663
63WNK41.05501574
64EPHA21.02888158
65MUSK1.02219428
66CAMK2B1.01887766
67RPS6KA51.01844749
68EPHA40.98092045
69PRKCG0.94802094
70CDK50.94162211
71CDK150.93606051
72PRKCZ0.93595881
73PINK10.92182989
74CDK180.91943228
75RPS6KB20.90482870
76PAK60.89839489
77CDK11A0.89442594
78BLK0.87089254
79DYRK1A0.87047386
80DYRK20.86648118
81DYRK1B0.86477594
82MAP3K30.84686076
83ABL20.83377925
84GRK60.82601215
85CAMK2D0.82483483
86ROCK20.81512832
87PRPF4B0.80603211
88TLK10.76758530
89PAK30.76745565
90CSNK1A1L0.76663369
91CDK40.76222035
92PDPK10.75651134
93TBK10.75005077
94MAP3K60.74675517
95LRRK20.73619285
96MATK0.72943708
97MELK0.72174219
98ATR0.71675565
99PTK20.70875732
100CDK70.70614044
101STK110.68759839
102LMTK20.67165480
103MAPKAPK30.66532125
104MAPK130.66148332
105BRSK10.64655013
106STK40.63688623
107CDK120.62382542
108IKBKB0.61568016
109CAMKK20.61401237
110ILK0.61162563
111CSNK1G30.58848034
112MAPK120.57768675
113AKT20.56824089
114MAP3K20.55694255
115TTN0.55616674
116KSR10.55614117
117CSNK1G20.54957999
118PRKACA0.54594570
119MTOR0.54426765
120MAP3K80.54049740
121AURKA0.52945429
122PRKCE0.52262386
123KDR0.51967499
124CSNK1E0.51926223
125PIM20.51701236
126CCNB10.51678370
127CDC42BPA0.51590584
128MAP2K60.50926252
129MST40.50832273
130RET0.50718805
131HIPK20.50341837
132BUB10.50254157
133PAK10.49191026
134RAF10.48693622
135EIF2AK10.48488619
136TTK0.48305247
137BMPR1B0.47999654
138MAP3K110.47901863
139BMX0.47888367
140PKN20.47502418
141TAOK10.47185565
142MYLK0.46168046
143MAP3K70.44935521
144PRKACG0.44441451
145CDK90.44244058
146BRAF0.43732418
147RPS6KL10.43702186
148RPS6KC10.43702186
149ZAP700.42493928
150DAPK30.41961433
151INSRR0.41828297
152SIK20.41444990
153SGK2230.41240572
154SGK4940.41240572
155SGK10.40955555
156ICK0.40746029
157MAP3K10.40739959
158PLK10.40701667
159DAPK10.40654235
160CAMK1D0.40414933
161CHEK10.39407308
162AURKB0.38640866
163CDK80.37360704
164IRAK40.37097463
165MAP3K100.36652440
166RPS6KA60.34324000
167RPS6KA20.31208258
168PRKD20.30976636
169MAPKAPK20.30042118
170CSNK1G10.29905497

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.23369629
2Phototransduction_Homo sapiens_hsa047443.91221079
3Parkinsons disease_Homo sapiens_hsa050123.70470154
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.01895183
5Synaptic vesicle cycle_Homo sapiens_hsa047212.99523053
6Alzheimers disease_Homo sapiens_hsa050102.85223553
7Base excision repair_Homo sapiens_hsa034102.74946653
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73856550
9DNA replication_Homo sapiens_hsa030302.68382101
10Nicotine addiction_Homo sapiens_hsa050332.55468902
11Cardiac muscle contraction_Homo sapiens_hsa042602.51097969
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48628747
13Phenylalanine metabolism_Homo sapiens_hsa003602.38969334
14Huntingtons disease_Homo sapiens_hsa050162.38393039
15Collecting duct acid secretion_Homo sapiens_hsa049662.19589587
16Tyrosine metabolism_Homo sapiens_hsa003502.14785101
17Systemic lupus erythematosus_Homo sapiens_hsa053222.10237282
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03228653
19Pyrimidine metabolism_Homo sapiens_hsa002402.00500443
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97071342
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94494543
22Other glycan degradation_Homo sapiens_hsa005111.84898527
23RNA polymerase_Homo sapiens_hsa030201.84032298
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79656252
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77725140
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.75733069
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74547537
28Dopaminergic synapse_Homo sapiens_hsa047281.73237797
29GABAergic synapse_Homo sapiens_hsa047271.72072537
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.70875520
31Serotonergic synapse_Homo sapiens_hsa047261.70584754
32Amphetamine addiction_Homo sapiens_hsa050311.70418672
33Fanconi anemia pathway_Homo sapiens_hsa034601.69921725
34Ribosome_Homo sapiens_hsa030101.62917302
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60527336
36Mismatch repair_Homo sapiens_hsa034301.53201239
37Vitamin B6 metabolism_Homo sapiens_hsa007501.48946992
38Vibrio cholerae infection_Homo sapiens_hsa051101.45845620
39Proteasome_Homo sapiens_hsa030501.45073566
40Cocaine addiction_Homo sapiens_hsa050301.44322879
41Circadian entrainment_Homo sapiens_hsa047131.40020739
42Olfactory transduction_Homo sapiens_hsa047401.35934434
43Sulfur metabolism_Homo sapiens_hsa009201.35323083
44Homologous recombination_Homo sapiens_hsa034401.26874778
45Pyruvate metabolism_Homo sapiens_hsa006201.26044563
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23480289
47Salivary secretion_Homo sapiens_hsa049701.23186023
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21132947
49Cholinergic synapse_Homo sapiens_hsa047251.20283928
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19845736
51Taste transduction_Homo sapiens_hsa047421.18639551
52Histidine metabolism_Homo sapiens_hsa003401.16551828
53Nucleotide excision repair_Homo sapiens_hsa034201.14085454
54Long-term potentiation_Homo sapiens_hsa047201.12597985
55Morphine addiction_Homo sapiens_hsa050321.11892003
56Glutamatergic synapse_Homo sapiens_hsa047241.10749243
57Calcium signaling pathway_Homo sapiens_hsa040201.06290955
58Sulfur relay system_Homo sapiens_hsa041221.05979767
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04455603
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03715346
61Long-term depression_Homo sapiens_hsa047301.03651533
62Gastric acid secretion_Homo sapiens_hsa049711.03454024
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03015230
64N-Glycan biosynthesis_Homo sapiens_hsa005101.02782090
65Gap junction_Homo sapiens_hsa045401.02664929
66One carbon pool by folate_Homo sapiens_hsa006701.01475843
67Arginine biosynthesis_Homo sapiens_hsa002201.01399071
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01334083
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00021394
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99645782
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.99349068
72Galactose metabolism_Homo sapiens_hsa000520.93376114
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90374347
74Sphingolipid metabolism_Homo sapiens_hsa006000.88557773
75Glutathione metabolism_Homo sapiens_hsa004800.88338930
76Alcoholism_Homo sapiens_hsa050340.88176221
77RNA transport_Homo sapiens_hsa030130.86131021
78Cell cycle_Homo sapiens_hsa041100.83021223
79Insulin secretion_Homo sapiens_hsa049110.81039939
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80565024
81Butanoate metabolism_Homo sapiens_hsa006500.78688459
82Basal transcription factors_Homo sapiens_hsa030220.76924705
83Spliceosome_Homo sapiens_hsa030400.76212528
84Purine metabolism_Homo sapiens_hsa002300.75539551
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.75170305
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74865024
87Renin secretion_Homo sapiens_hsa049240.74514838
88Arginine and proline metabolism_Homo sapiens_hsa003300.74106464
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73593640
90Carbon metabolism_Homo sapiens_hsa012000.73381910
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72889177
92GnRH signaling pathway_Homo sapiens_hsa049120.71818157
93Oxytocin signaling pathway_Homo sapiens_hsa049210.71581674
94Pancreatic secretion_Homo sapiens_hsa049720.69671081
95Viral carcinogenesis_Homo sapiens_hsa052030.69454359
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.69444856
97Biosynthesis of amino acids_Homo sapiens_hsa012300.69024708
98Apoptosis_Homo sapiens_hsa042100.68627543
99Lysosome_Homo sapiens_hsa041420.68295904
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65067652
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63339461
102Dilated cardiomyopathy_Homo sapiens_hsa054140.63112893
103p53 signaling pathway_Homo sapiens_hsa041150.62198454
104Epstein-Barr virus infection_Homo sapiens_hsa051690.61250339
105HTLV-I infection_Homo sapiens_hsa051660.60344084
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59072890
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58754789
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55619681
109Non-small cell lung cancer_Homo sapiens_hsa052230.54954938
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54129385
111Hedgehog signaling pathway_Homo sapiens_hsa043400.52756083
112Folate biosynthesis_Homo sapiens_hsa007900.51322577
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51240628
114Basal cell carcinoma_Homo sapiens_hsa052170.48645269
115Primary immunodeficiency_Homo sapiens_hsa053400.48228274
116Acute myeloid leukemia_Homo sapiens_hsa052210.47612456
117Metabolic pathways_Homo sapiens_hsa011000.46831377
118Glucagon signaling pathway_Homo sapiens_hsa049220.46151179
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45812705
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45360041
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44596452
122Insulin signaling pathway_Homo sapiens_hsa049100.44312555
123mTOR signaling pathway_Homo sapiens_hsa041500.44037170
124Hepatitis C_Homo sapiens_hsa051600.42878608
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42810989
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40931040
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38641863
128VEGF signaling pathway_Homo sapiens_hsa043700.38550133
129Propanoate metabolism_Homo sapiens_hsa006400.37926244
130Vitamin digestion and absorption_Homo sapiens_hsa049770.36988867
131Herpes simplex infection_Homo sapiens_hsa051680.36424436
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36356429
133Oocyte meiosis_Homo sapiens_hsa041140.34884191
134Protein export_Homo sapiens_hsa030600.34415737
135Non-homologous end-joining_Homo sapiens_hsa034500.33879117
136Fatty acid elongation_Homo sapiens_hsa000620.33721141
137Melanogenesis_Homo sapiens_hsa049160.33052862
138Fructose and mannose metabolism_Homo sapiens_hsa000510.32526057
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.32315340
140Pancreatic cancer_Homo sapiens_hsa052120.32199263
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.31761008
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31583839
143Bladder cancer_Homo sapiens_hsa052190.30839583
144Estrogen signaling pathway_Homo sapiens_hsa049150.30804580
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30658141
146Chronic myeloid leukemia_Homo sapiens_hsa052200.30476375
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27308848
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26891758
149Bile secretion_Homo sapiens_hsa049760.26321680
150SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25234600
151Notch signaling pathway_Homo sapiens_hsa043300.25206695
152Tryptophan metabolism_Homo sapiens_hsa003800.25205949
153Intestinal immune network for IgA production_Homo sapiens_hsa046720.24490491
154TNF signaling pathway_Homo sapiens_hsa046680.24047017
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23730368
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23303753
157Vascular smooth muscle contraction_Homo sapiens_hsa042700.22896537
158Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20561101
159Adipocytokine signaling pathway_Homo sapiens_hsa049200.19922375
160Pentose phosphate pathway_Homo sapiens_hsa000300.19641974
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.19609573
162ErbB signaling pathway_Homo sapiens_hsa040120.17597065
163Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17529354
164cAMP signaling pathway_Homo sapiens_hsa040240.16793825
165AMPK signaling pathway_Homo sapiens_hsa041520.16495930

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