UFSP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly conserved cysteine protease. The protein cleaves two C-terminal residues from ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein. Activation of ubiquitin-fold modifier 1 by the encoded protein exposes a C-terminal glycine residue that allows interaction with other proteins and transfer to its target protein. An allelic variant of this gene has been associated with Beukes hip dysplasia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)6.07864361
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.90568543
3protein complex biogenesis (GO:0070271)4.68182502
4mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.39403030
5mitochondrial respiratory chain complex I assembly (GO:0032981)4.39403030
6NADH dehydrogenase complex assembly (GO:0010257)4.39403030
7DNA double-strand break processing (GO:0000729)4.32996594
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.25942531
9mitochondrial respiratory chain complex assembly (GO:0033108)4.17917652
10respiratory electron transport chain (GO:0022904)4.13854008
11electron transport chain (GO:0022900)4.04943420
12ATP synthesis coupled proton transport (GO:0015986)4.04285858
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.04285858
14ER overload response (GO:0006983)3.84093290
15respiratory chain complex IV assembly (GO:0008535)3.75239478
16protein neddylation (GO:0045116)3.74901426
17cullin deneddylation (GO:0010388)3.73119348
18cytochrome complex assembly (GO:0017004)3.72168554
19cornea development in camera-type eye (GO:0061303)3.65971642
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.60883766
21CENP-A containing nucleosome assembly (GO:0034080)3.55908582
22chromatin remodeling at centromere (GO:0031055)3.52944458
23nucleotide transmembrane transport (GO:1901679)3.52646696
24energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.52520745
25ATP hydrolysis coupled proton transport (GO:0015991)3.52520745
26regulation of timing of cell differentiation (GO:0048505)3.46343762
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.45238428
28phagosome maturation (GO:0090382)3.44546708
29Golgi transport vesicle coating (GO:0048200)3.43764126
30COPI coating of Golgi vesicle (GO:0048205)3.43764126
31regulation of development, heterochronic (GO:0040034)3.42683702
32protein deneddylation (GO:0000338)3.39914656
33chaperone-mediated protein transport (GO:0072321)3.38536644
34dopamine transport (GO:0015872)3.33969833
35fatty acid elongation (GO:0030497)3.31272125
36peptidyl-histidine modification (GO:0018202)3.30026478
37nonmotile primary cilium assembly (GO:0035058)3.27254284
38GTP biosynthetic process (GO:0006183)3.22260890
39cholesterol biosynthetic process (GO:0006695)3.22232054
40transferrin transport (GO:0033572)3.20010057
41protein maturation by protein folding (GO:0022417)3.18668701
42cilium morphogenesis (GO:0060271)3.14125091
43presynaptic membrane assembly (GO:0097105)3.12501606
44sterol biosynthetic process (GO:0016126)3.12109954
45mannosylation (GO:0097502)3.06890813
46DNA ligation (GO:0006266)3.00768419
47regulation of mitochondrial translation (GO:0070129)2.99266759
48trivalent inorganic cation transport (GO:0072512)2.98661907
49ferric iron transport (GO:0015682)2.98661907
50guanosine-containing compound biosynthetic process (GO:1901070)2.97506136
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95848975
52water-soluble vitamin biosynthetic process (GO:0042364)2.94524852
53synapsis (GO:0007129)2.92782630
54establishment of integrated proviral latency (GO:0075713)2.92427554
55histone exchange (GO:0043486)2.92185092
56GDP-mannose metabolic process (GO:0019673)2.91900867
57positive regulation of mitochondrial fission (GO:0090141)2.90206454
58DNA damage response, detection of DNA damage (GO:0042769)2.90026451
59epithelial cilium movement (GO:0003351)2.89891078
60hydrogen ion transmembrane transport (GO:1902600)2.88997620
61regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.86652690
62platelet dense granule organization (GO:0060155)2.84307558
63oxidative phosphorylation (GO:0006119)2.84013692
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83022988
65proton transport (GO:0015992)2.82753318
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80934017
67neutrophil activation involved in immune response (GO:0002283)2.78519212
68presynaptic membrane organization (GO:0097090)2.76814002
69hydrogen transport (GO:0006818)2.76448441
70protein K11-linked ubiquitination (GO:0070979)2.76209773
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75688426
72amino acid salvage (GO:0043102)2.75331694
73L-methionine salvage (GO:0071267)2.75331694
74L-methionine biosynthetic process (GO:0071265)2.75331694
75branched-chain amino acid catabolic process (GO:0009083)2.74156415
76dorsal/ventral axis specification (GO:0009950)2.72502342
77proteasome assembly (GO:0043248)2.72108497
78deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.70009170
79protein localization to cilium (GO:0061512)2.69879092
80positive regulation of cellular amine metabolic process (GO:0033240)2.68064654
81regulation of mitotic spindle checkpoint (GO:1903504)2.67271292
82regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.67271292
83resolution of meiotic recombination intermediates (GO:0000712)2.66613783
84organelle disassembly (GO:1903008)2.66070161
85inner mitochondrial membrane organization (GO:0007007)2.66023393
86dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.65832203
87replication fork processing (GO:0031297)2.65494344
88histone H2A acetylation (GO:0043968)2.64203815
89maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.63960002
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63399800
912-deoxyribonucleotide biosynthetic process (GO:0009265)2.62550653
92deoxyribose phosphate biosynthetic process (GO:0046385)2.62550653
93peptide hormone processing (GO:0016486)2.62268601
94response to nitrosative stress (GO:0051409)2.61130308
95negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60920213
96DNA replication-independent nucleosome organization (GO:0034724)2.59971997
97DNA replication-independent nucleosome assembly (GO:0006336)2.59971997
98regulation of coenzyme metabolic process (GO:0051196)2.59564581
99regulation of cofactor metabolic process (GO:0051193)2.59564581
100aldehyde catabolic process (GO:0046185)2.59109361
101reactive oxygen species biosynthetic process (GO:1903409)2.57944125
102pH reduction (GO:0045851)2.57878619
103regulation of cilium movement (GO:0003352)2.57834114
104heart process (GO:0003015)2.57013754
105heart contraction (GO:0060047)2.57013754
106L-serine metabolic process (GO:0006563)2.55882020
107response to redox state (GO:0051775)2.55536554
108negative regulation of neurotransmitter transport (GO:0051589)2.55299981
109regulation of acyl-CoA biosynthetic process (GO:0050812)2.55010614
110kinetochore organization (GO:0051383)2.54863179
111aerobic respiration (GO:0009060)2.54578733
112pyrimidine nucleobase catabolic process (GO:0006208)2.54534867
113regulation of catecholamine metabolic process (GO:0042069)2.54257159
114regulation of dopamine metabolic process (GO:0042053)2.54257159
115anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.53720010
116negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.50671436
117negative regulation of ligase activity (GO:0051352)2.50671436
118nucleoside diphosphate catabolic process (GO:0009134)2.50589573
119DNA catabolic process, exonucleolytic (GO:0000738)2.50530292
120GMP metabolic process (GO:0046037)2.50005915
121intraciliary transport (GO:0042073)2.49107531
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.49103792
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.49103792
124regulation of hexokinase activity (GO:1903299)2.48782586
125regulation of glucokinase activity (GO:0033131)2.48782586
126CTP metabolic process (GO:0046036)2.47983946
127CTP biosynthetic process (GO:0006241)2.47983946
128kinetochore assembly (GO:0051382)2.47643855
129intracellular protein transmembrane import (GO:0044743)2.47409950
130ubiquinone metabolic process (GO:0006743)2.47253798
131NADH metabolic process (GO:0006734)2.46448880
132establishment of viral latency (GO:0019043)2.46278070
133intracellular pH reduction (GO:0051452)2.45292023
134regulation of oxidative phosphorylation (GO:0002082)2.44383667
135isoprenoid biosynthetic process (GO:0008299)2.44195099
136metaphase plate congression (GO:0051310)2.43328441
137quinone metabolic process (GO:1901661)2.42928534
138long-chain fatty acid biosynthetic process (GO:0042759)2.42636466
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.41687385
140protein-cofactor linkage (GO:0018065)2.41583232
141spliceosomal snRNP assembly (GO:0000387)2.40147220
142succinate metabolic process (GO:0006105)2.40029525
143viral protein processing (GO:0019082)2.39647427
144purine nucleoside triphosphate biosynthetic process (GO:0009145)2.39498959
145respiratory burst (GO:0045730)2.38946760
146negative regulation of mast cell activation (GO:0033004)2.38699547
147negative regulation of DNA recombination (GO:0045910)2.38134947
148tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37670924
149RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37670924
150negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37547882
1517-methylguanosine mRNA capping (GO:0006370)2.36729719
152termination of RNA polymerase III transcription (GO:0006386)2.36652833
153transcription elongation from RNA polymerase III promoter (GO:0006385)2.36652833
154cofactor catabolic process (GO:0051187)2.35775415
155lactate metabolic process (GO:0006089)2.34969296
156regulation of sulfur metabolic process (GO:0042762)2.34965836
157daunorubicin metabolic process (GO:0044597)2.34630857
158polyketide metabolic process (GO:0030638)2.34630857
159doxorubicin metabolic process (GO:0044598)2.34630857
160peptidyl-cysteine modification (GO:0018198)2.34601860
161UTP biosynthetic process (GO:0006228)2.34470957
162mitotic metaphase plate congression (GO:0007080)2.34327418
163sequestering of metal ion (GO:0051238)2.34154357
164ubiquinone biosynthetic process (GO:0006744)2.34121305
165quinone biosynthetic process (GO:1901663)2.34121305
166positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.34086820
167negative regulation of neurotransmitter secretion (GO:0046929)2.33646154
168photoreceptor cell development (GO:0042461)2.32830966
169purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.32621733
170antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.32118987
171fucose metabolic process (GO:0006004)2.31177574
172positive regulation of protein homodimerization activity (GO:0090073)2.30241161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56579001
2GBX2_23144817_ChIP-Seq_PC3_Human3.12333430
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.90623420
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.83595310
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76034307
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60092252
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54277862
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51072779
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42167280
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34222197
11VDR_22108803_ChIP-Seq_LS180_Human2.33181081
12ZNF274_21170338_ChIP-Seq_K562_Hela2.31554707
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31483646
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.29925227
15TAF15_26573619_Chip-Seq_HEK293_Human2.29249676
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29064230
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.27990678
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26285782
19IGF1R_20145208_ChIP-Seq_DFB_Human2.21916487
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16698588
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09384792
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.02367246
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98717897
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96521585
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92087283
26FUS_26573619_Chip-Seq_HEK293_Human1.86925548
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.84927543
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83345825
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83307259
30P300_19829295_ChIP-Seq_ESCs_Human1.82202781
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68421074
32ELK1_19687146_ChIP-ChIP_HELA_Human1.66070366
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65656024
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65460358
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59503964
36ER_23166858_ChIP-Seq_MCF-7_Human1.57612230
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50541095
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49723911
39EZH2_22144423_ChIP-Seq_EOC_Human1.47926186
40HTT_18923047_ChIP-ChIP_STHdh_Human1.47599954
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47559579
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47378949
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43761559
44GATA1_22025678_ChIP-Seq_K562_Human1.43701569
45MYC_18940864_ChIP-ChIP_HL60_Human1.43508147
46RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43307879
47STAT3_18555785_Chip-Seq_ESCs_Mouse1.42818701
48FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.42527871
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.42104930
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40739938
51IRF1_19129219_ChIP-ChIP_H3396_Human1.39703691
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38633667
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37393883
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.37388647
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37253968
56* FOXP3_21729870_ChIP-Seq_TREG_Human1.37218665
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36845671
58P53_22387025_ChIP-Seq_ESCs_Mouse1.36480451
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35526672
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33950242
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.33067967
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32285901
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31946042
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.29813456
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.28678448
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28061982
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27710598
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26576198
69CBP_20019798_ChIP-Seq_JUKART_Human1.25082793
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25082793
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24850069
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24850069
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.24738945
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.24551797
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.24518943
76VDR_23849224_ChIP-Seq_CD4+_Human1.23715530
77JUN_21703547_ChIP-Seq_K562_Human1.22943758
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.22143634
79EWS_26573619_Chip-Seq_HEK293_Human1.20589561
80RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20545796
81SOX2_18555785_Chip-Seq_ESCs_Mouse1.19295763
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17997697
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17759716
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.17458300
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16617237
86SMAD4_21799915_ChIP-Seq_A2780_Human1.16478058
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16121879
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15788813
89P300_18555785_Chip-Seq_ESCs_Mouse1.14852826
90SMAD1_18555785_Chip-Seq_ESCs_Mouse1.14770146
91NMYC_18555785_Chip-Seq_ESCs_Mouse1.13913767
92DCP1A_22483619_ChIP-Seq_HELA_Human1.13780644
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13714458
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13308340
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.13154424
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12382165
97NANOG_19829295_ChIP-Seq_ESCs_Human1.12282515
98SOX2_19829295_ChIP-Seq_ESCs_Human1.12282515
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11967378
100E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11724765
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11246342
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11147481
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11049657
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08613179
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07950940
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07945700
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.07138546
108* TP53_22573176_ChIP-Seq_HFKS_Human1.06383276
109PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06087351
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04031743
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.03706284
112AR_20517297_ChIP-Seq_VCAP_Human1.03198006
113RNF2_27304074_Chip-Seq_NSC_Mouse1.03177686
114IRF8_21731497_ChIP-ChIP_J774_Mouse1.02579777
115PU1_27457419_Chip-Seq_LIVER_Mouse1.02231563
116CBX2_27304074_Chip-Seq_ESCs_Mouse1.02212756
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02042297
118AR_25329375_ChIP-Seq_VCAP_Human1.01290063
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01021883
120MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00471157
121ZFX_18555785_Chip-Seq_ESCs_Mouse1.00218926
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99878760
123GABP_19822575_ChIP-Seq_HepG2_Human0.99775027
124ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99744959
125KLF4_18555785_Chip-Seq_ESCs_Mouse0.99453003
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99166405
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98948772
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98214798
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97860265
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97251735
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96957864
132* TTF2_22483619_ChIP-Seq_HELA_Human0.95597334
133ELK1_22589737_ChIP-Seq_MCF10A_Human0.93941796
134CTCF_18555785_Chip-Seq_ESCs_Mouse0.93686535
135EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93354211
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92969418
137REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92958893
138* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92811719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.52509485
2MP0010386_abnormal_urinary_bladder3.34832682
3MP0008789_abnormal_olfactory_epithelium3.28081418
4MP0003880_abnormal_central_pattern3.03863204
5MP0001986_abnormal_taste_sensitivity2.83349349
6MP0003183_abnormal_peptide_metabolism2.81846090
7MP0002938_white_spotting2.79351329
8MP0005499_abnormal_olfactory_system2.75659780
9MP0005394_taste/olfaction_phenotype2.75659780
10MP0009697_abnormal_copulation2.67898010
11MP0004043_abnormal_pH_regulation2.61496164
12MP0005379_endocrine/exocrine_gland_phen2.57153522
13MP0005646_abnormal_pituitary_gland2.33946549
14MP0001905_abnormal_dopamine_level2.33634842
15MP0008877_abnormal_DNA_methylation2.28902779
16MP0002876_abnormal_thyroid_physiology2.21662404
17MP0005257_abnormal_intraocular_pressure2.19877215
18MP0003806_abnormal_nucleotide_metabolis2.16222095
19MP0002638_abnormal_pupillary_reflex2.09819757
20MP0002837_dystrophic_cardiac_calcinosis2.08135462
21MP0006276_abnormal_autonomic_nervous2.06253817
22MP0008058_abnormal_DNA_repair2.01333384
23MP0001529_abnormal_vocalization1.97931455
24MP0000013_abnormal_adipose_tissue1.93848396
25MP0002736_abnormal_nociception_after1.88360205
26MP0001764_abnormal_homeostasis1.75771875
27MP0002102_abnormal_ear_morphology1.75456133
28MP0002163_abnormal_gland_morphology1.74614986
29MP0001188_hyperpigmentation1.74455200
30MP0002139_abnormal_hepatobiliary_system1.72425473
31MP0004215_abnormal_myocardial_fiber1.70937159
32MP0003941_abnormal_skin_development1.69390828
33MP0006036_abnormal_mitochondrial_physio1.69177538
34MP0004142_abnormal_muscle_tone1.67230247
35MP0001293_anophthalmia1.65615370
36MP0002693_abnormal_pancreas_physiology1.64279707
37MP0002064_seizures1.61462201
38MP0003868_abnormal_feces_composition1.58044511
39MP0009046_muscle_twitch1.57910921
40MP0005551_abnormal_eye_electrophysiolog1.57847847
41MP0001968_abnormal_touch/_nociception1.57714481
42MP0002234_abnormal_pharynx_morphology1.57413840
43MP0002735_abnormal_chemical_nociception1.56778308
44MP0005084_abnormal_gallbladder_morpholo1.56525937
45MP0009780_abnormal_chondrocyte_physiolo1.55939040
46MP0005171_absent_coat_pigmentation1.52225482
47MP0002272_abnormal_nervous_system1.50616069
48MP0000778_abnormal_nervous_system1.50599665
49MP0008875_abnormal_xenobiotic_pharmacok1.50276926
50MP0003136_yellow_coat_color1.49013097
51MP0000372_irregular_coat_pigmentation1.48763951
52MP0003121_genomic_imprinting1.47407954
53MP0009745_abnormal_behavioral_response1.47316786
54MP0005058_abnormal_lysosome_morphology1.47016808
55MP0001501_abnormal_sleep_pattern1.46541804
56MP0002233_abnormal_nose_morphology1.42113669
57MP0003937_abnormal_limbs/digits/tail_de1.38900394
58MP0000049_abnormal_middle_ear1.36000263
59MP0003186_abnormal_redox_activity1.35640305
60MP0004782_abnormal_surfactant_physiolog1.34354112
61MP0002572_abnormal_emotion/affect_behav1.31929812
62MP0005220_abnormal_exocrine_pancreas1.31062285
63MP0010030_abnormal_orbit_morphology1.31042949
64MP0001542_abnormal_bone_strength1.28650266
65MP0003137_abnormal_impulse_conducting1.27793867
66MP0005248_abnormal_Harderian_gland1.27358452
67MP0003724_increased_susceptibility_to1.26773738
68MP0003122_maternal_imprinting1.25971702
69MP0004133_heterotaxia1.24706502
70MP0010094_abnormal_chromosome_stability1.23714210
71MP0003787_abnormal_imprinting1.22904585
72MP0003718_maternal_effect1.22808988
73MP0006072_abnormal_retinal_apoptosis1.22624752
74MP0002734_abnormal_mechanical_nocicepti1.22532833
75MP0005636_abnormal_mineral_homeostasis1.21584147
76MP0000631_abnormal_neuroendocrine_gland1.20426367
77MP0002751_abnormal_autonomic_nervous1.20084273
78MP0000647_abnormal_sebaceous_gland1.19689876
79MP0000749_muscle_degeneration1.18818505
80MP0000613_abnormal_salivary_gland1.18024693
81MP0008932_abnormal_embryonic_tissue1.17320541
82MP0005365_abnormal_bile_salt1.17114192
83MP0001944_abnormal_pancreas_morphology1.16455633
84MP0002909_abnormal_adrenal_gland1.16317739
85MP0001984_abnormal_olfaction1.15965719
86MP0001664_abnormal_digestion1.15139104
87MP0004145_abnormal_muscle_electrophysio1.14671478
88MP0006035_abnormal_mitochondrial_morpho1.13104267
89MP0004134_abnormal_chest_morphology1.12472880
90MP0003635_abnormal_synaptic_transmissio1.11538781
91MP0002148_abnormal_hypersensitivity_rea1.11511291
92MP0002067_abnormal_sensory_capabilities1.11492201
93MP0005535_abnormal_body_temperature1.11236527
94MP0008995_early_reproductive_senescence1.09164058
95MP0003755_abnormal_palate_morphology1.09064833
96MP0005253_abnormal_eye_physiology1.08810083
97MP0008004_abnormal_stomach_pH1.08637146
98MP0005391_vision/eye_phenotype1.08404391
99MP0000681_abnormal_thyroid_gland1.08270042
100MP0004957_abnormal_blastocyst_morpholog1.07008259
101MP0005408_hypopigmentation1.06484199
102MP0000920_abnormal_myelination1.04498866
103MP0005645_abnormal_hypothalamus_physiol1.04193622
104MP0003567_abnormal_fetal_cardiomyocyte1.03191477
105MP0003890_abnormal_embryonic-extraembry1.02804804
106MP0004147_increased_porphyrin_level1.02739407
107MP0003646_muscle_fatigue1.02673982
108MP0005503_abnormal_tendon_morphology1.02278733
109MP0001970_abnormal_pain_threshold1.01701764
110MP0001299_abnormal_eye_distance/1.00062242
111MP0001324_abnormal_eye_pigmentation0.99384119
112MP0002063_abnormal_learning/memory/cond0.98999838
113MP0002132_abnormal_respiratory_system0.98716200
114MP0002229_neurodegeneration0.97894511
115MP0006292_abnormal_olfactory_placode0.95929245
116MP0002697_abnormal_eye_size0.94862477
117MP0001485_abnormal_pinna_reflex0.94160093
118MP0008260_abnormal_autophagy0.93258456
119MP0001486_abnormal_startle_reflex0.93044584
120MP0002653_abnormal_ependyma_morphology0.92609915
121MP0004924_abnormal_behavior0.92273829
122MP0005386_behavior/neurological_phenoty0.92273829
123MP0000230_abnormal_systemic_arterial0.92240796
124MP0002933_joint_inflammation0.91745626
125MP0001286_abnormal_eye_development0.91441860
126MP0001666_abnormal_nutrient_absorption0.90069498
127MP0005187_abnormal_penis_morphology0.90006449
128MP0001440_abnormal_grooming_behavior0.89924352
129MP0002160_abnormal_reproductive_system0.87166878
130MP0002282_abnormal_trachea_morphology0.86882285
131MP0000751_myopathy0.86451424
132MP0002822_catalepsy0.86146568
133MP0001502_abnormal_circadian_rhythm0.85590505
134MP0002419_abnormal_innate_immunity0.85520729
135MP0000566_synostosis0.85159049
136MP0001963_abnormal_hearing_physiology0.84730310
137MP0002733_abnormal_thermal_nociception0.84140883
138MP0002254_reproductive_system_inflammat0.83985669
139MP0000538_abnormal_urinary_bladder0.82963602
140MP0005195_abnormal_posterior_eye0.81739203
141MP0002177_abnormal_outer_ear0.81637103
142MP0003077_abnormal_cell_cycle0.81515672
143MP0003656_abnormal_erythrocyte_physiolo0.81182635
144MP0003938_abnormal_ear_development0.80888435
145MP0002078_abnormal_glucose_homeostasis0.80604440
146MP0002090_abnormal_vision0.80466101
147MP0005376_homeostasis/metabolism_phenot0.79576244
148MP0003119_abnormal_digestive_system0.79205179
149MP0002210_abnormal_sex_determination0.79042413
150MP0002752_abnormal_somatic_nervous0.78107733
151MP0004742_abnormal_vestibular_system0.78083961
152MP0004085_abnormal_heartbeat0.77641068
153MP0003011_delayed_dark_adaptation0.77451081
154MP0005332_abnormal_amino_acid0.77286133
155MP0000026_abnormal_inner_ear0.76551942
156MP0006054_spinal_hemorrhage0.76444692
157MP0001929_abnormal_gametogenesis0.75882339
158MP0004084_abnormal_cardiac_muscle0.75644224
159MP0004270_analgesia0.74711869
160MP0005085_abnormal_gallbladder_physiolo0.73967935
161MP0003633_abnormal_nervous_system0.73029278
162MP0002972_abnormal_cardiac_muscle0.71620047
163MP0003221_abnormal_cardiomyocyte_apopto0.70924816
164MP0002557_abnormal_social/conspecific_i0.70909904
165MP0005620_abnormal_muscle_contractility0.70223620
166MP0003111_abnormal_nucleus_morphology0.69978963

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.36990641
2Abnormal mitochondria in muscle tissue (HP:0008316)4.98337235
3Mitochondrial inheritance (HP:0001427)4.50922046
4Acute encephalopathy (HP:0006846)4.50828311
5Progressive macrocephaly (HP:0004481)4.50587823
6Increased CSF lactate (HP:0002490)4.02044896
7Hepatocellular necrosis (HP:0001404)3.85370500
8Irregular epiphyses (HP:0010582)3.70153391
9Hepatic necrosis (HP:0002605)3.68681059
10Hypothermia (HP:0002045)3.44427029
11True hermaphroditism (HP:0010459)3.28998956
12Exercise-induced muscle cramps (HP:0003710)3.25798925
13Medial flaring of the eyebrow (HP:0010747)3.17978431
14Hypoplasia of the fovea (HP:0007750)3.15922074
15Aplasia/Hypoplasia of the fovea (HP:0008060)3.15922074
16Cerebral edema (HP:0002181)3.05200319
17Renal Fanconi syndrome (HP:0001994)3.03751067
18Abnormal hair whorl (HP:0010721)2.98631166
19Epiphyseal dysplasia (HP:0002656)2.96795523
20Pancreatic cysts (HP:0001737)2.93651738
21Abnormality of the fovea (HP:0000493)2.93100984
22Congenital primary aphakia (HP:0007707)2.89788038
23Neuroendocrine neoplasm (HP:0100634)2.87101378
24Hyperglycinemia (HP:0002154)2.85800885
25Optic disc pallor (HP:0000543)2.83511121
26Pheochromocytoma (HP:0002666)2.81898898
27Gait imbalance (HP:0002141)2.80610596
283-Methylglutaconic aciduria (HP:0003535)2.78209203
29Lactic acidosis (HP:0003128)2.77136064
30Nephrogenic diabetes insipidus (HP:0009806)2.75786079
31Abnormality of the labia minora (HP:0012880)2.75103462
32Atonic seizures (HP:0010819)2.73906406
33Increased hepatocellular lipid droplets (HP:0006565)2.70122307
34Lipid accumulation in hepatocytes (HP:0006561)2.69170892
35Small epiphyses (HP:0010585)2.66367673
36Abnormality of glycolysis (HP:0004366)2.63424850
37Increased serum pyruvate (HP:0003542)2.63424850
38Microvesicular hepatic steatosis (HP:0001414)2.62194918
39Respiratory failure (HP:0002878)2.62113758
40Type I transferrin isoform profile (HP:0003642)2.57562383
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.56123348
42Colon cancer (HP:0003003)2.54686322
43Exercise intolerance (HP:0003546)2.54245947
44Optic nerve hypoplasia (HP:0000609)2.53073088
45Molar tooth sign on MRI (HP:0002419)2.51894534
46Abnormality of midbrain morphology (HP:0002418)2.51894534
47Vitreoretinal degeneration (HP:0000655)2.47476002
48Flat capital femoral epiphysis (HP:0003370)2.45394412
49Increased serum lactate (HP:0002151)2.44109060
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43368650
51Abnormal protein N-linked glycosylation (HP:0012347)2.43368650
52Abnormal protein glycosylation (HP:0012346)2.43368650
53Abnormal glycosylation (HP:0012345)2.43368650
54Abnormality of serine family amino acid metabolism (HP:0010894)2.40934671
55Abnormality of glycine metabolism (HP:0010895)2.40934671
56Nephronophthisis (HP:0000090)2.39561658
57Vacuolated lymphocytes (HP:0001922)2.38797217
58Irregular vertebral endplates (HP:0003301)2.36440872
59Leukodystrophy (HP:0002415)2.35092307
60Focal motor seizures (HP:0011153)2.34693561
61Abnormality of serum amino acid levels (HP:0003112)2.33542612
62Hyperglycinuria (HP:0003108)2.32968852
63Abnormality of aromatic amino acid family metabolism (HP:0004338)2.31343029
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30683619
65Postaxial foot polydactyly (HP:0001830)2.29943230
66Abnormal tarsal ossification (HP:0008369)2.27308258
67Epileptic encephalopathy (HP:0200134)2.26792873
68Abnormality of alanine metabolism (HP:0010916)2.25093150
69Hyperalaninemia (HP:0003348)2.25093150
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25093150
71Hyperventilation (HP:0002883)2.23902275
72Abnormality of renal resorption (HP:0011038)2.23534982
73Stenosis of the external auditory canal (HP:0000402)2.22931165
74Symptomatic seizures (HP:0011145)2.22589854
75Vaginal atresia (HP:0000148)2.20736116
76Generalized aminoaciduria (HP:0002909)2.20379844
77Abnormality of the vertebral endplates (HP:0005106)2.20235166
78Genital tract atresia (HP:0001827)2.19455307
79Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16512858
80Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16512858
81Methylmalonic acidemia (HP:0002912)2.16079839
82Septo-optic dysplasia (HP:0100842)2.15815609
83Abnormality of methionine metabolism (HP:0010901)2.14870356
84Disproportionate short-trunk short stature (HP:0003521)2.13857509
85Short tibia (HP:0005736)2.13439219
86Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13082725
87Reduced antithrombin III activity (HP:0001976)2.12677458
88Hypoglycemic seizures (HP:0002173)2.09542415
89Postaxial hand polydactyly (HP:0001162)2.09156045
90Rhabdomyosarcoma (HP:0002859)2.06474213
91Poor suck (HP:0002033)2.05254512
92Methylmalonic aciduria (HP:0012120)2.05146805
93Increased intramyocellular lipid droplets (HP:0012240)2.05069303
94Anencephaly (HP:0002323)2.04534610
95Poor coordination (HP:0002370)2.04022646
96Abnormal pupillary function (HP:0007686)2.03894425
97Glycosuria (HP:0003076)2.03669322
98Abnormality of urine glucose concentration (HP:0011016)2.03669322
99Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03126975
100Broad foot (HP:0001769)2.03118070
101Abnormality of the intrinsic pathway (HP:0010989)2.02754432
102Gonadotropin excess (HP:0000837)2.02494896
103Intestinal atresia (HP:0011100)2.01700824
104Degeneration of anterior horn cells (HP:0002398)2.01696317
105Abnormality of the anterior horn cell (HP:0006802)2.01696317
106Bifid tongue (HP:0010297)1.99682401
107Abnormality of the femoral head (HP:0003368)1.98958651
108Sclerocornea (HP:0000647)1.98231373
109Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96845831
110Conjugated hyperbilirubinemia (HP:0002908)1.96438065
111Hyperinsulinemic hypoglycemia (HP:0000825)1.95572914
112Autoamputation (HP:0001218)1.94544036
113Aplasia/Hypoplasia of the tibia (HP:0005772)1.94153070
114Supernumerary spleens (HP:0009799)1.94134242
115Beaking of vertebral bodies (HP:0004568)1.91628074
116Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88368171
117Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.87384609
118Abnormality of femoral epiphyses (HP:0006499)1.87384609
119Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86412588
120Absent epiphyses (HP:0010577)1.86412588
121Abnormality of the epiphysis of the femoral head (HP:0010574)1.86233874
122Hyperphosphaturia (HP:0003109)1.84469650
123Barrel-shaped chest (HP:0001552)1.84112769
124Decreased testicular size (HP:0008734)1.83610935
125Occipital encephalocele (HP:0002085)1.83492027
126Meckel diverticulum (HP:0002245)1.83136705
127Specific learning disability (HP:0001328)1.83108748
128Abnormal lung lobation (HP:0002101)1.82684367
129Metaphyseal irregularity (HP:0003025)1.82552566
130Abnormality of the ileum (HP:0001549)1.82306893
131Absence seizures (HP:0002121)1.82164881
132X-linked dominant inheritance (HP:0001423)1.81895063
133Abnormality of the renal medulla (HP:0100957)1.81406257
134Hypoglycemic coma (HP:0001325)1.81317084
135Pancreatic islet-cell hyperplasia (HP:0004510)1.81177383
136Median cleft lip (HP:0000161)1.80907271
137Increased muscle lipid content (HP:0009058)1.80178392
138Aplasia/Hypoplasia of the lens (HP:0008063)1.79664230
139Preaxial hand polydactyly (HP:0001177)1.79491956
140Febrile seizures (HP:0002373)1.79306060
141Renal cortical cysts (HP:0000803)1.78903225
142Delayed epiphyseal ossification (HP:0002663)1.77802754
143Abnormality of incisor morphology (HP:0011063)1.77587754
144Pancreatic fibrosis (HP:0100732)1.76985850
145Respiratory difficulties (HP:0002880)1.76849952
146Cortical visual impairment (HP:0100704)1.76578684
147Parakeratosis (HP:0001036)1.76016150
148Cortical dysplasia (HP:0002539)1.74114476
149Medulloblastoma (HP:0002885)1.72607673
150Lethargy (HP:0001254)1.72347634
151Aplasia/Hypoplasia of the uvula (HP:0010293)1.71843725
152Congenital hepatic fibrosis (HP:0002612)1.71609031
153Congenital sensorineural hearing impairment (HP:0008527)1.70902626
154Narrow forehead (HP:0000341)1.70501962
155Exertional dyspnea (HP:0002875)1.70427235
156Abnormal rod and cone electroretinograms (HP:0008323)1.67046846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.68937718
2STK163.18942983
3TRIM282.95107396
4MAP3K122.64201353
5MST42.48807579
6NEK12.42513170
7PBK2.42148142
8EIF2AK32.41891017
9NME12.40616201
10INSRR2.14260366
11MAP4K22.14097070
12MAP2K72.08586654
13SRPK11.99259900
14BMPR1B1.99138069
15CDK191.95668981
16AKT31.95425091
17BUB11.90381945
18PLK21.83277558
19OXSR11.82440465
20ADRBK21.76692466
21ARAF1.76002753
22WEE11.75998063
23MUSK1.70103894
24MKNK21.64863447
25MKNK11.62271344
26OBSCN1.61679943
27BMPR21.61084845
28VRK21.57445218
29PIM21.54918055
30NME21.52624308
31PLK31.50663435
32CDK81.50650338
33MARK11.47176198
34TNIK1.44652968
35CSNK1G21.41171871
36GRK71.40325561
37RIPK41.40178976
38CSNK1G11.40062994
39FRK1.37932393
40IRAK41.36093518
41TEC1.33320434
42EPHA41.32081618
43TTK1.27321174
44IRAK31.26438486
45VRK11.25556325
46CAMKK21.25556107
47BRAF1.25200300
48PLK41.25118723
49MYLK1.24827031
50ACVR1B1.22507756
51DYRK31.21313374
52CSNK1A1L1.20189099
53PIK3CG1.20182878
54CCNB11.20156443
55PRKCE1.20104138
56FLT31.17524442
57PINK11.16486272
58DYRK21.12511571
59CDC71.11509127
60STK241.10331366
61STK391.09976656
62MAPKAPK51.08981207
63EPHB21.08065605
64MAP3K141.06198191
65MAP3K31.06067542
66TSSK61.03660662
67PLK11.01663768
68NTRK31.01295045
69MAP3K41.00153704
70STK38L0.96303704
71TAOK30.95384826
72NEK60.94455264
73YES10.90982871
74PAK30.90893861
75BCR0.90252985
76ERBB30.90004597
77SIK30.89307612
78BCKDK0.87567453
79PIK3CA0.87134726
80WNK40.86210907
81ADRBK10.85438008
82ZAK0.85085454
83CAMK2D0.82170128
84PASK0.81687790
85TXK0.80951725
86PTK2B0.79168668
87CAMK2B0.77591967
88GRK10.76696813
89MAPK130.75576279
90GRK50.75414679
91MET0.75058310
92LIMK10.74169855
93CAMK2A0.72287832
94TAF10.72219262
95PHKG10.70943575
96PHKG20.70943575
97SGK4940.69998205
98SGK2230.69998205
99NUAK10.69821893
100MST1R0.69536285
101PNCK0.69269650
102ERBB40.69128804
103EIF2AK10.68391783
104SGK20.67296797
105BRSK10.67116717
106MAPK150.67036509
107BRSK20.66874384
108KIT0.65257803
109TRPM70.65168098
110CDK30.64899500
111PDK20.63453488
112MINK10.62449002
113DAPK10.60942602
114LYN0.60139255
115PRKCG0.59580395
116SYK0.59348904
117RPS6KA40.58793007
118PRKG20.56759926
119PRPF4B0.56464420
120WNK30.56415741
121PKN10.54650199
122MAP2K40.51094334
123EIF2AK20.50561197
124AURKB0.50203941
125STK30.49669344
126FES0.47550716
127CAMK2G0.46712265
128MAP3K20.46267481
129CSNK1G30.44453808
130NEK90.44191965
131NTRK10.43379626
132ATM0.43209699
133TGFBR10.43163472
134PRKCD0.43077872
135DYRK1A0.42517107
136PRKACA0.41618800
137ATR0.41599607
138NEK20.41115624
139FGFR10.40398390
140IRAK10.39732870
141PRKG10.39730886
142ROCK20.39434866
143BRD40.38087467
144PRKCQ0.37936218
145CSNK2A20.37624524
146CSNK1A10.37507245
147ROCK10.36990069
148NTRK20.36650643
149TIE10.35344686
150PRKCA0.33548335
151CDK140.33358826
152UHMK10.32435115
153CSNK2A10.31225342
154PRKACB0.30286761

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.76134363
2Oxidative phosphorylation_Homo sapiens_hsa001904.40806672
3Parkinsons disease_Homo sapiens_hsa050123.27913228
4Collecting duct acid secretion_Homo sapiens_hsa049662.89128809
5Sulfur metabolism_Homo sapiens_hsa009202.81269845
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.77831105
7Vibrio cholerae infection_Homo sapiens_hsa051102.63691988
8Alzheimers disease_Homo sapiens_hsa050102.60913908
9Proteasome_Homo sapiens_hsa030502.39839025
10SNARE interactions in vesicular transport_Homo sapiens_hsa041302.24280617
11Huntingtons disease_Homo sapiens_hsa050162.17729133
12Mismatch repair_Homo sapiens_hsa034302.15497276
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13604325
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.07411055
15Fatty acid elongation_Homo sapiens_hsa000622.01453149
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73011669
17Fanconi anemia pathway_Homo sapiens_hsa034601.68472058
18Synaptic vesicle cycle_Homo sapiens_hsa047211.67746853
19Steroid biosynthesis_Homo sapiens_hsa001001.62761092
20RNA degradation_Homo sapiens_hsa030181.60535731
21Rheumatoid arthritis_Homo sapiens_hsa053231.58926781
22Homologous recombination_Homo sapiens_hsa034401.54002177
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52997475
24Folate biosynthesis_Homo sapiens_hsa007901.50411714
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47930141
26Phagosome_Homo sapiens_hsa041451.47777911
27Nucleotide excision repair_Homo sapiens_hsa034201.39509887
28RNA transport_Homo sapiens_hsa030131.38129126
29Phototransduction_Homo sapiens_hsa047441.35234226
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27339588
31DNA replication_Homo sapiens_hsa030301.27001439
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26525062
33Spliceosome_Homo sapiens_hsa030401.25409455
34RNA polymerase_Homo sapiens_hsa030201.24603029
35Nicotine addiction_Homo sapiens_hsa050331.20709163
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19049484
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16147171
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15646703
39Biosynthesis of amino acids_Homo sapiens_hsa012301.13908293
40Sphingolipid metabolism_Homo sapiens_hsa006001.13347452
41Pyruvate metabolism_Homo sapiens_hsa006201.13163901
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12776240
43Other glycan degradation_Homo sapiens_hsa005111.10945289
44N-Glycan biosynthesis_Homo sapiens_hsa005101.10356142
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10343528
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09274769
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06598370
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06380133
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06268563
50Peroxisome_Homo sapiens_hsa041461.04704528
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04590902
52Base excision repair_Homo sapiens_hsa034101.01353094
53Histidine metabolism_Homo sapiens_hsa003401.00977074
54Serotonergic synapse_Homo sapiens_hsa047260.97842693
55Metabolic pathways_Homo sapiens_hsa011000.93865871
56Oocyte meiosis_Homo sapiens_hsa041140.90725546
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90605400
58Lysosome_Homo sapiens_hsa041420.90586265
59Ribosome_Homo sapiens_hsa030100.90118685
60Type I diabetes mellitus_Homo sapiens_hsa049400.88648406
61Propanoate metabolism_Homo sapiens_hsa006400.88272111
62Regulation of autophagy_Homo sapiens_hsa041400.85061967
63Phenylalanine metabolism_Homo sapiens_hsa003600.84298167
64Tyrosine metabolism_Homo sapiens_hsa003500.83806909
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80960076
66Fatty acid metabolism_Homo sapiens_hsa012120.79375289
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79031864
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78286151
69GABAergic synapse_Homo sapiens_hsa047270.78279938
70Insulin secretion_Homo sapiens_hsa049110.76352883
71Arachidonic acid metabolism_Homo sapiens_hsa005900.74878227
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74816971
73Galactose metabolism_Homo sapiens_hsa000520.73454793
74Cardiac muscle contraction_Homo sapiens_hsa042600.72845273
75One carbon pool by folate_Homo sapiens_hsa006700.71994602
76Cell cycle_Homo sapiens_hsa041100.71923365
77Taste transduction_Homo sapiens_hsa047420.71009005
78Ether lipid metabolism_Homo sapiens_hsa005650.67509290
79Selenocompound metabolism_Homo sapiens_hsa004500.67312038
80Amphetamine addiction_Homo sapiens_hsa050310.65911165
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65651255
82Fatty acid degradation_Homo sapiens_hsa000710.65427903
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65041415
84Butanoate metabolism_Homo sapiens_hsa006500.64220700
85Purine metabolism_Homo sapiens_hsa002300.64152840
86Cocaine addiction_Homo sapiens_hsa050300.63273172
87Hedgehog signaling pathway_Homo sapiens_hsa043400.62698048
88Basal cell carcinoma_Homo sapiens_hsa052170.62290642
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62244575
90Pyrimidine metabolism_Homo sapiens_hsa002400.59888665
91Legionellosis_Homo sapiens_hsa051340.58031775
92Basal transcription factors_Homo sapiens_hsa030220.57233293
93Morphine addiction_Homo sapiens_hsa050320.57022947
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56881889
95Arginine and proline metabolism_Homo sapiens_hsa003300.55317382
96Nitrogen metabolism_Homo sapiens_hsa009100.55024127
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54450157
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52552032
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.52526048
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51653676
101Fructose and mannose metabolism_Homo sapiens_hsa000510.51014000
102mRNA surveillance pathway_Homo sapiens_hsa030150.48480523
103Circadian entrainment_Homo sapiens_hsa047130.47248978
104Pentose phosphate pathway_Homo sapiens_hsa000300.46898882
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.46257447
106Starch and sucrose metabolism_Homo sapiens_hsa005000.45014221
107Vitamin B6 metabolism_Homo sapiens_hsa007500.44345571
108p53 signaling pathway_Homo sapiens_hsa041150.42947076
109Dopaminergic synapse_Homo sapiens_hsa047280.42240560
110Caffeine metabolism_Homo sapiens_hsa002320.41559145
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41005466
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40938693
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40743146
114Linoleic acid metabolism_Homo sapiens_hsa005910.40428244
115Pancreatic secretion_Homo sapiens_hsa049720.36676684
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34771507
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34696491
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34166315
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34093360
120Hippo signaling pathway_Homo sapiens_hsa043900.33749871
121Vitamin digestion and absorption_Homo sapiens_hsa049770.33517974
122Circadian rhythm_Homo sapiens_hsa047100.33323329
123Glutathione metabolism_Homo sapiens_hsa004800.31616802
124beta-Alanine metabolism_Homo sapiens_hsa004100.30674896
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30632544
126Carbon metabolism_Homo sapiens_hsa012000.30422453
127Retinol metabolism_Homo sapiens_hsa008300.30323884
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30273401
129Renin-angiotensin system_Homo sapiens_hsa046140.28671632
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28610142
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.27657388
132Chemical carcinogenesis_Homo sapiens_hsa052040.26582627
133Wnt signaling pathway_Homo sapiens_hsa043100.26240177
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.25755492
135Arginine biosynthesis_Homo sapiens_hsa002200.25144727
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24270593
137TGF-beta signaling pathway_Homo sapiens_hsa043500.23976802
138Tryptophan metabolism_Homo sapiens_hsa003800.23536248
139Non-homologous end-joining_Homo sapiens_hsa034500.23203546

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