UGDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)8.11971896
2polyketide metabolic process (GO:0030638)8.11971896
3doxorubicin metabolic process (GO:0044598)8.11971896
4aminoglycoside antibiotic metabolic process (GO:0030647)7.25022029
5primary alcohol catabolic process (GO:0034310)5.24003383
6* cellular glucuronidation (GO:0052695)5.21332201
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.12591024
8L-phenylalanine catabolic process (GO:0006559)5.12591024
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.01759059
10L-phenylalanine metabolic process (GO:0006558)5.01759059
11* glucuronate metabolic process (GO:0019585)4.96022557
12* uronic acid metabolic process (GO:0006063)4.96022557
13sulfur amino acid catabolic process (GO:0000098)4.87757544
14aromatic amino acid family catabolic process (GO:0009074)4.82081153
15negative regulation of fibrinolysis (GO:0051918)4.68417043
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.64583000
17indole-containing compound catabolic process (GO:0042436)4.57136855
18indolalkylamine catabolic process (GO:0046218)4.57136855
19tryptophan catabolic process (GO:0006569)4.57136855
20cysteine metabolic process (GO:0006534)4.52431082
21kynurenine metabolic process (GO:0070189)4.36980733
22bile acid biosynthetic process (GO:0006699)4.35751864
23protein carboxylation (GO:0018214)4.35722616
24peptidyl-glutamic acid carboxylation (GO:0017187)4.35722616
25regulation of fibrinolysis (GO:0051917)4.33446183
26glyoxylate metabolic process (GO:0046487)4.32655709
27homocysteine metabolic process (GO:0050667)4.28917927
28regulation of plasminogen activation (GO:0010755)4.27840313
29tryptophan metabolic process (GO:0006568)4.26328952
30urea cycle (GO:0000050)4.17438716
31urea metabolic process (GO:0019627)4.17438716
32regulation of protein activation cascade (GO:2000257)4.13081566
33complement activation, alternative pathway (GO:0006957)4.08782512
34epoxygenase P450 pathway (GO:0019373)4.07847765
35xenobiotic catabolic process (GO:0042178)4.06174401
36COPII vesicle coating (GO:0048208)4.01662999
37alpha-linolenic acid metabolic process (GO:0036109)4.01315112
38response to nitrosative stress (GO:0051409)4.00231782
39glycoside metabolic process (GO:0016137)3.99365134
40high-density lipoprotein particle remodeling (GO:0034375)3.95884183
41regulation of complement activation (GO:0030449)3.94288952
42bile acid metabolic process (GO:0008206)3.83484716
43bile acid and bile salt transport (GO:0015721)3.77501076
44nitrogen cycle metabolic process (GO:0071941)3.76026308
45flavonoid metabolic process (GO:0009812)3.74320021
46fibrinolysis (GO:0042730)3.73749206
47triglyceride homeostasis (GO:0070328)3.72615735
48acylglycerol homeostasis (GO:0055090)3.72615735
49drug catabolic process (GO:0042737)3.72530258
50regulation of cholesterol homeostasis (GO:2000188)3.69415021
51intestinal cholesterol absorption (GO:0030299)3.68696721
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.67474519
53* nucleotide-sugar biosynthetic process (GO:0009226)3.66345294
54benzene-containing compound metabolic process (GO:0042537)3.65743695
55lysine catabolic process (GO:0006554)3.64987508
56lysine metabolic process (GO:0006553)3.64987508
57regulation of triglyceride catabolic process (GO:0010896)3.64422468
58retinal metabolic process (GO:0042574)3.60302147
59aldehyde catabolic process (GO:0046185)3.60115353
60amino-acid betaine metabolic process (GO:0006577)3.58128654
61positive regulation of extracellular matrix organization (GO:1903055)3.56424653
62progesterone metabolic process (GO:0042448)3.56377065
63intestinal absorption (GO:0050892)3.54852230
64negative regulation of sterol transport (GO:0032372)3.53445344
65negative regulation of cholesterol transport (GO:0032375)3.53445344
66Golgi transport vesicle coating (GO:0048200)3.52179616
67COPI coating of Golgi vesicle (GO:0048205)3.52179616
68reverse cholesterol transport (GO:0043691)3.51897068
69regulation of cholesterol esterification (GO:0010872)3.45590644
70serine family amino acid catabolic process (GO:0009071)3.45255386
71maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.42801654
72aromatic amino acid family metabolic process (GO:0009072)3.40606656
73plasma lipoprotein particle remodeling (GO:0034369)3.38801927
74protein-lipid complex remodeling (GO:0034368)3.38801927
75macromolecular complex remodeling (GO:0034367)3.38801927
76UDP-N-acetylglucosamine metabolic process (GO:0006047)3.38440345
77phospholipid efflux (GO:0033700)3.37955646
78plasma lipoprotein particle clearance (GO:0034381)3.37622863
79very-low-density lipoprotein particle assembly (GO:0034379)3.35924092
80protein retention in ER lumen (GO:0006621)3.34562498
81cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.31856129
82lipoprotein metabolic process (GO:0042157)3.27537182
83collagen fibril organization (GO:0030199)3.25507550
84ethanol oxidation (GO:0006069)3.24612373
85quinone metabolic process (GO:1901661)3.24117307
86exogenous drug catabolic process (GO:0042738)3.23598749
87plasma lipoprotein particle assembly (GO:0034377)3.20276658
88serine family amino acid metabolic process (GO:0009069)3.18770775
89serine family amino acid biosynthetic process (GO:0009070)3.18395871
90regulation of bile acid biosynthetic process (GO:0070857)3.18055024
91cholesterol efflux (GO:0033344)3.17192601
92positive regulation of fatty acid biosynthetic process (GO:0045723)3.17129966
93cellular modified amino acid catabolic process (GO:0042219)3.17059685
94positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.15339667
95protein hydroxylation (GO:0018126)3.14588673
96tyrosine metabolic process (GO:0006570)3.13936158
97alpha-amino acid catabolic process (GO:1901606)3.12998766
98peptidyl-proline hydroxylation (GO:0019511)3.12668221
99indolalkylamine metabolic process (GO:0006586)3.09375120
100amine catabolic process (GO:0009310)3.08119723
101cellular biogenic amine catabolic process (GO:0042402)3.08119723
102cholesterol homeostasis (GO:0042632)3.07674810
103sterol homeostasis (GO:0055092)3.05573401
104positive regulation of fatty acid beta-oxidation (GO:0032000)3.05452628
105positive regulation of lipid catabolic process (GO:0050996)3.04976994
106cell adhesion mediated by integrin (GO:0033627)3.04970738
107protein-lipid complex assembly (GO:0065005)3.02553494
108glycine metabolic process (GO:0006544)3.01842452
109glutamate metabolic process (GO:0006536)3.00702669
110coenzyme catabolic process (GO:0009109)2.99956309
111drug transmembrane transport (GO:0006855)2.99848125
112negative regulation of protein activation cascade (GO:2000258)2.99046264
113cellular amino acid catabolic process (GO:0009063)2.98228724
114keratan sulfate catabolic process (GO:0042340)2.93034471
115negative regulation of lipase activity (GO:0060192)2.92949113
116cellular aldehyde metabolic process (GO:0006081)2.91321032
117C21-steroid hormone metabolic process (GO:0008207)2.88039339
118arginine metabolic process (GO:0006525)2.87469465
119drug metabolic process (GO:0017144)2.87113473
120opsonization (GO:0008228)2.87101503
121chondrocyte proliferation (GO:0035988)2.86885909
122regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.86564295
123phospholipid homeostasis (GO:0055091)2.84818126
124digestion (GO:0007586)2.79844903
125omega-hydroxylase P450 pathway (GO:0097267)2.69789097
126ribosome assembly (GO:0042255)2.62918452
127L-serine metabolic process (GO:0006563)2.60305276
128cobalamin metabolic process (GO:0009235)2.59608877
129negative regulation of coagulation (GO:0050819)2.57564571
130desmosome organization (GO:0002934)2.56603559
131primary alcohol metabolic process (GO:0034308)2.56000707
132anterior/posterior axis specification, embryo (GO:0008595)2.55606735
133positive regulation of endothelial cell apoptotic process (GO:2000353)2.52925423
1344-hydroxyproline metabolic process (GO:0019471)2.51855686
135negative regulation of wound healing (GO:0061045)2.50742301
136ethanol metabolic process (GO:0006067)2.50490255
137regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48462073
138negative regulation of complement activation (GO:0045916)2.42681154
139negative regulation of hemostasis (GO:1900047)2.41519837
140negative regulation of blood coagulation (GO:0030195)2.41519837
141retinoid metabolic process (GO:0001523)2.39740275
142regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.35491603
143diterpenoid metabolic process (GO:0016101)2.35364985
144ER overload response (GO:0006983)2.34249290
145cyclooxygenase pathway (GO:0019371)2.32597487
146terpenoid metabolic process (GO:0006721)2.31851308
147regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.31437921
148transcytosis (GO:0045056)2.30441522
149skin morphogenesis (GO:0043589)2.29766787
150lung vasculature development (GO:0060426)2.29261436
151regulation of transforming growth factor beta2 production (GO:0032909)2.27476856
152gap junction assembly (GO:0016264)2.25438579
153cholesterol biosynthetic process (GO:0006695)2.24809496
154regulation of metalloenzyme activity (GO:0048552)2.22869385
155* nucleotide-sugar metabolic process (GO:0009225)2.22801472
156regulation of apoptotic cell clearance (GO:2000425)2.22754511
157acute-phase response (GO:0006953)2.22412387
158phenylpropanoid metabolic process (GO:0009698)2.21261905
159L-ascorbic acid metabolic process (GO:0019852)2.18860299
160retina vasculature morphogenesis in camera-type eye (GO:0061299)2.18334915
161Leydig cell differentiation (GO:0033327)2.18060081
162vesicle coating (GO:0006901)2.17807139
163paraxial mesoderm development (GO:0048339)2.17773230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.58665448
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.17468399
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.34143728
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.93521559
5TRIM28_21343339_ChIP-Seq_HEK293_Human4.74037616
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.73678903
7TP63_17297297_ChIP-ChIP_HaCaT_Human4.37142768
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.83793824
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.51749818
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.51215865
11RARG_19884340_ChIP-ChIP_MEFs_Mouse3.39559145
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.20174120
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.18458920
14CLOCK_20551151_ChIP-Seq_293T_Human2.89639684
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.58739400
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.33083265
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.25712816
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.13905009
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13298105
20PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.09757606
21* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.97101902
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79957690
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72791154
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72059020
25CDX2_20551321_ChIP-Seq_CACO-2_Human1.71039410
26SOX2_20726797_ChIP-Seq_SW620_Human1.70075678
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.69014959
28SALL4_18804426_ChIP-ChIP_XEN_Mouse1.69013676
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66174175
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64844769
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64844769
32ELK1_19687146_ChIP-ChIP_HELA_Human1.63707878
33* ESR2_21235772_ChIP-Seq_MCF-7_Human1.63139231
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61952175
35* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61197619
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.60246914
37GATA4_25053715_ChIP-Seq_YYC3_Human1.58348404
38* CJUN_26792858_Chip-Seq_BT549_Human1.55711715
39* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55687616
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53316237
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.49877322
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49418006
43TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.46492062
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44635735
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43945779
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41308416
47* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41277699
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40552353
49SOX17_20123909_ChIP-Seq_XEN_Mouse1.36569625
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36429368
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34183698
52GATA1_22025678_ChIP-Seq_K562_Human1.34131841
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33770762
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33770762
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.32968525
56E2F7_22180533_ChIP-Seq_HELA_Human1.32952841
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.30264045
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29574614
59EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.29278558
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28949057
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28818911
62* FOXA2_19822575_ChIP-Seq_HepG2_Human1.26574894
63* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25868164
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25290406
65AR_21909140_ChIP-Seq_LNCAP_Human1.22955351
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22313945
67ZNF263_19887448_ChIP-Seq_K562_Human1.20820842
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19060628
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.18670191
70* EP300_21415370_ChIP-Seq_HL-1_Mouse1.17961103
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17759538
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.17235556
73* HNF4A_19822575_ChIP-Seq_HepG2_Human1.16952116
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16246757
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14839958
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14378501
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13547777
78CDX2_22108803_ChIP-Seq_LS180_Human1.12338747
79* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11199689
80AHR_22903824_ChIP-Seq_MCF-7_Human1.09283094
81GATA6_25053715_ChIP-Seq_YYC3_Human1.09180667
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08069345
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06637994
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06544111
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06132597
86ATF3_27146783_Chip-Seq_COLON_Human1.05865031
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.04354435
88BRD4_25478319_ChIP-Seq_HGPS_Human1.03960458
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03636630
90WT1_19549856_ChIP-ChIP_CCG9911_Human1.02161447
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00437333
92GATA3_24758297_ChIP-Seq_MCF-7_Human1.00384153
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99637670
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99008351
95NANOG_16153702_ChIP-ChIP_HESCs_Human0.98813155
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97783936
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95913309
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95734287
99EOMES_21245162_ChIP-Seq_HESCs_Human0.95093126
100FOXA1_25552417_ChIP-Seq_VCAP_Human0.93666491
101POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92997608
102ELF5_23300383_ChIP-Seq_T47D_Human0.92532747
103SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91666813
104* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91225835
105DCP1A_22483619_ChIP-Seq_HELA_Human0.90954485
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90862804
107RACK7_27058665_Chip-Seq_MCF-7_Human0.90503366
108MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90190803
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89690525
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88939686
111TP53_18474530_ChIP-ChIP_U2OS_Human0.86544468
112PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86195780
113ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85728082
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83884521
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83485310
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82173476
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81574045
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.76755062
119EGR1_19374776_ChIP-ChIP_THP-1_Human0.76312713
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.76024849
121P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75438714
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74280675
123SOX9_24532713_ChIP-Seq_HFSC_Mouse0.73793363
124UBF1/2_26484160_Chip-Seq_HMECs_Human0.72378249
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71529601
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70515338
127ELK3_25401928_ChIP-Seq_HUVEC_Human0.67884755
128IRF8_22096565_ChIP-ChIP_GC-B_Human0.67720601
129EGR1_19032775_ChIP-ChIP_M12_Human0.67535081
130TP63_23658742_ChIP-Seq_EP156T_Human0.67390289
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.63386988
132SMC1_22415368_ChIP-Seq_MEFs_Mouse0.63180427
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.61803081
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.61579710
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.61185877
136* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.60407933
137BRD4_27068464_Chip-Seq_AML-cells_Mouse0.59003259
138* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58782732
139* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.56928275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.00192391
2MP0002139_abnormal_hepatobiliary_system5.85906868
3MP0005085_abnormal_gallbladder_physiolo4.50069168
4MP0005365_abnormal_bile_salt4.25541558
5MP0008875_abnormal_xenobiotic_pharmacok3.89191979
6MP0003806_abnormal_nucleotide_metabolis3.50145558
7MP0003252_abnormal_bile_duct3.39462186
8MP0003705_abnormal_hypodermis_morpholog3.35097992
9MP0008438_abnormal_cutaneous_collagen3.34363008
10MP0005503_abnormal_tendon_morphology2.77233305
11MP0003950_abnormal_plasma_membrane2.74547371
12MP0010329_abnormal_lipoprotein_level2.40451373
13MP0005275_abnormal_skin_tensile2.35059425
14MP0001666_abnormal_nutrient_absorption2.32657420
15MP0009384_cardiac_valve_regurgitation2.30385027
16MP0003195_calcinosis2.28652495
17MP0009840_abnormal_foam_cell2.08311144
18MP0005332_abnormal_amino_acid1.91679488
19MP0005083_abnormal_biliary_tract1.67607043
20MP0004019_abnormal_vitamin_homeostasis1.62876869
21MP0003279_aneurysm1.62600695
22MP0002282_abnormal_trachea_morphology1.61564425
23MP0002933_joint_inflammation1.57843114
24MP0005023_abnormal_wound_healing1.49334758
25MP0009053_abnormal_anal_canal1.46038400
26MP0009697_abnormal_copulation1.45158652
27MP0000609_abnormal_liver_physiology1.45070261
28MP0005623_abnormal_meninges_morphology1.43956818
29MP0010030_abnormal_orbit_morphology1.42497792
30MP0001958_emphysema1.39029115
31MP0000163_abnormal_cartilage_morphology1.38298632
32MP0003937_abnormal_limbs/digits/tail_de1.38194156
33MP0002060_abnormal_skin_morphology1.35198829
34MP0005319_abnormal_enzyme/_coenzyme1.34946860
35MP0004134_abnormal_chest_morphology1.30343877
36MP0009250_abnormal_appendicular_skeleto1.29335572
37MP0003186_abnormal_redox_activity1.29155749
38MP0010352_gastrointestinal_tract_polyps1.28800511
39MP0010368_abnormal_lymphatic_system1.28680209
40MP0003868_abnormal_feces_composition1.27190068
41MP0008004_abnormal_stomach_pH1.26173312
42MP0003890_abnormal_embryonic-extraembry1.24841350
43MP0002118_abnormal_lipid_homeostasis1.22603868
44MP0002138_abnormal_hepatobiliary_system1.20904338
45MP0002896_abnormal_bone_mineralization1.19390381
46MP0004957_abnormal_blastocyst_morpholog1.18718684
47MP0003566_abnormal_cell_adhesion1.18581284
48MP0002938_white_spotting1.15733877
49MP0010386_abnormal_urinary_bladder1.15361756
50MP0005508_abnormal_skeleton_morphology1.11955761
51MP0002115_abnormal_skeleton_extremities1.11868027
52MP0001299_abnormal_eye_distance/1.08865017
53MP0006054_spinal_hemorrhage1.07989055
54MP0003191_abnormal_cellular_cholesterol1.07668971
55MP0008932_abnormal_embryonic_tissue1.05436224
56MP0010678_abnormal_skin_adnexa1.04060399
57MP0009643_abnormal_urine_homeostasis1.02865628
58MP0001243_abnormal_dermal_layer1.02839568
59MP0001542_abnormal_bone_strength1.01751784
60MP0001533_abnormal_skeleton_physiology0.99763211
61MP0004272_abnormal_basement_membrane0.99137458
62MP0003693_abnormal_embryo_hatching0.96148569
63MP0005390_skeleton_phenotype0.95743411
64MP0002877_abnormal_melanocyte_morpholog0.90848290
65MP0000462_abnormal_digestive_system0.90827487
66MP0000598_abnormal_liver_morphology0.89639336
67MP0002697_abnormal_eye_size0.89457294
68MP0000537_abnormal_urethra_morphology0.88523983
69MP0003942_abnormal_urinary_system0.88127356
70MP0005257_abnormal_intraocular_pressure0.87711852
71MP0000627_abnormal_mammary_gland0.87503111
72MP0003283_abnormal_digestive_organ0.87421031
73MP0002113_abnormal_skeleton_development0.86422109
74MP0005084_abnormal_gallbladder_morpholo0.86242014
75MP0001764_abnormal_homeostasis0.84672622
76MP0001661_extended_life_span0.84137773
77MP0001915_intracranial_hemorrhage0.82729733
78MP0005220_abnormal_exocrine_pancreas0.80878085
79MP0004233_abnormal_muscle_weight0.80568179
80MP0003436_decreased_susceptibility_to0.79991650
81MP0001286_abnormal_eye_development0.79828679
82MP0008007_abnormal_cellular_replicative0.79445145
83MP0005197_abnormal_uvea_morphology0.79096555
84MP0003300_gastrointestinal_ulcer0.78458595
85MP0000613_abnormal_salivary_gland0.78272189
86MP0003091_abnormal_cell_migration0.77975630
87MP0000467_abnormal_esophagus_morphology0.77819895
88MP0000538_abnormal_urinary_bladder0.77812673
89MP0002089_abnormal_postnatal_growth/wei0.77708740
90MP0003011_delayed_dark_adaptation0.77583279
91MP0005584_abnormal_enzyme/coenzyme_acti0.77166791
92MP0005248_abnormal_Harderian_gland0.75641577
93* MP0002084_abnormal_developmental_patter0.73538826
94MP0003122_maternal_imprinting0.73148770
95MP0000534_abnormal_ureter_morphology0.72783901
96MP0010234_abnormal_vibrissa_follicle0.72556830
97MP0005164_abnormal_response_to0.72476718
98MP0003941_abnormal_skin_development0.71677088
99MP0003656_abnormal_erythrocyte_physiolo0.71211477
100MP0003795_abnormal_bone_structure0.70703822
101MP0000013_abnormal_adipose_tissue0.70233000
102MP0000762_abnormal_tongue_morphology0.70081185
103MP0009764_decreased_sensitivity_to0.69712941
104MP0002295_abnormal_pulmonary_circulatio0.69558417
105MP0002168_other_aberrant_phenotype0.69332108
106MP0002796_impaired_skin_barrier0.68638942
107MP0005408_hypopigmentation0.67784115
108MP0003943_abnormal_hepatobiliary_system0.66900101
109MP0001881_abnormal_mammary_gland0.66231547
110MP0000432_abnormal_head_morphology0.66088970
111MP0009763_increased_sensitivity_to0.65743524
112MP0001697_abnormal_embryo_size0.65529305
113* MP0001672_abnormal_embryogenesis/_devel0.65066740
114* MP0005380_embryogenesis_phenotype0.65066740
115* MP0001730_embryonic_growth_arrest0.64287319
116MP0001293_anophthalmia0.64185706
117* MP0002085_abnormal_embryonic_tissue0.63475428
118MP0004264_abnormal_extraembryonic_tissu0.62700339
119MP0003936_abnormal_reproductive_system0.62290915
120MP0005376_homeostasis/metabolism_phenot0.61376494
121MP0009780_abnormal_chondrocyte_physiolo0.61028283
122MP0002136_abnormal_kidney_physiology0.59518884
123MP0005395_other_phenotype0.58950151
124MP0002249_abnormal_larynx_morphology0.58011803
125MP0002254_reproductive_system_inflammat0.57918402
126MP0000767_abnormal_smooth_muscle0.57736356
127MP0002233_abnormal_nose_morphology0.57418717
128MP0005166_decreased_susceptibility_to0.55999041
129MP0005636_abnormal_mineral_homeostasis0.55477075
130MP0002998_abnormal_bone_remodeling0.55173984
131MP0001756_abnormal_urination0.54202476
132MP0001270_distended_abdomen0.53944235
133MP0003453_abnormal_keratinocyte_physiol0.53857623
134MP0008469_abnormal_protein_level0.53026913
135MP0001663_abnormal_digestive_system0.53009084
136MP0002108_abnormal_muscle_morphology0.52818300
137MP0002111_abnormal_tail_morphology0.52050304
138MP0002109_abnormal_limb_morphology0.50943108
139MP0009642_abnormal_blood_homeostasis0.50191877
140MP0005381_digestive/alimentary_phenotyp0.49209157
141MP0003755_abnormal_palate_morphology0.48548959

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)4.71796346
2Cupped ribs (HP:0000887)4.67885176
3Abnormal tarsal ossification (HP:0008369)4.63791569
4Intrahepatic cholestasis (HP:0001406)4.51470261
5Vitreoretinal degeneration (HP:0000655)4.30944669
6Deep venous thrombosis (HP:0002625)4.29257875
7Xanthomatosis (HP:0000991)4.14124386
8Irregular epiphyses (HP:0010582)4.14070222
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.06782978
10Hypobetalipoproteinemia (HP:0003563)4.05350688
11Flat acetabular roof (HP:0003180)3.96785469
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.73049964
13Protrusio acetabuli (HP:0003179)3.64104900
14Abnormal foot bone ossification (HP:0010675)3.63065099
15Abnormality of glutamine family amino acid metabolism (HP:0010902)3.58246773
16Neonatal short-limb short stature (HP:0008921)3.45976410
17Premature rupture of membranes (HP:0001788)3.41603138
18Hypoplastic ischia (HP:0003175)3.29927874
19Hypolipoproteinemia (HP:0010981)3.25606863
20Prolonged partial thromboplastin time (HP:0003645)3.19013236
21Cervical subluxation (HP:0003308)3.05033019
22Delayed epiphyseal ossification (HP:0002663)3.00388403
23Complement deficiency (HP:0004431)3.00277995
24Abnormality of the ischium (HP:0003174)2.99344448
25Reduced antithrombin III activity (HP:0001976)2.98200009
26Flat capital femoral epiphysis (HP:0003370)2.93936272
27Fat malabsorption (HP:0002630)2.92012585
28Abnormal cartilage morphology (HP:0002763)2.90778339
29Hypoalphalipoproteinemia (HP:0003233)2.90335191
30Abnormality of carpal bone ossification (HP:0006257)2.87120926
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.80472689
32Metaphyseal cupping (HP:0003021)2.79139789
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.76427101
34Small epiphyses (HP:0010585)2.76175117
35Arterial tortuosity (HP:0005116)2.75368721
36Osteoarthritis (HP:0002758)2.75351078
37Tetraparesis (HP:0002273)2.74770904
38Myocardial infarction (HP:0001658)2.73693558
39Abnormality of the common coagulation pathway (HP:0010990)2.73231240
40Protuberant abdomen (HP:0001538)2.68969660
41Abnormality of complement system (HP:0005339)2.65303303
42Epidermoid cyst (HP:0200040)2.65195034
43Vascular tortuosity (HP:0004948)2.62727305
44Microglossia (HP:0000171)2.57830586
45Coxa vara (HP:0002812)2.57465126
46Arthropathy (HP:0003040)2.57311536
47Conjugated hyperbilirubinemia (HP:0002908)2.56997066
48Genu varum (HP:0002970)2.56769351
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.55782186
50Beaking of vertebral bodies (HP:0004568)2.54453632
51Hydroxyprolinuria (HP:0003080)2.54159995
52Abnormality of proline metabolism (HP:0010907)2.54159995
53Hyperlipoproteinemia (HP:0010980)2.50409438
54Abnormal delivery (HP:0001787)2.50154191
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.48874532
56Cardiovascular calcification (HP:0011915)2.43866260
57Abnormality of the intrinsic pathway (HP:0010989)2.42025251
58Hyperammonemia (HP:0001987)2.37140444
59Abnormality of dentin (HP:0010299)2.33835060
60Metaphyseal irregularity (HP:0003025)2.32544585
61Abnormal ossification of hand bones (HP:0005921)2.31807674
62Flattened epiphyses (HP:0003071)2.29552432
63Platyspondyly (HP:0000926)2.29240922
64Spontaneous abortion (HP:0005268)2.28881357
65Glomerulonephritis (HP:0000099)2.27849981
66Peritonitis (HP:0002586)2.26985639
67Vascular calcification (HP:0004934)2.26876864
68Joint hemorrhage (HP:0005261)2.23158749
69Soft skin (HP:0000977)2.21020963
70Abnormality of the acetabulum (HP:0003170)2.20486738
71Abnormality of methionine metabolism (HP:0010901)2.19659858
72Stillbirth (HP:0003826)2.18381340
73Thoracolumbar scoliosis (HP:0002944)2.18114987
74Hypercholesterolemia (HP:0003124)2.17556526
75Ectopia lentis (HP:0001083)2.17509576
76Ovoid vertebral bodies (HP:0003300)2.17317786
77Abnormal hand bone ossification (HP:0010660)2.16536496
78Abnormality of the vertebral endplates (HP:0005106)2.16401337
79Vertebral clefting (HP:0008428)2.13576882
80Hyperglycinuria (HP:0003108)2.11481328
81Abnormality of glycolysis (HP:0004366)2.11042271
82Aortic aneurysm (HP:0004942)2.09920655
83Hypoglycemic coma (HP:0001325)2.09682386
84Steatorrhea (HP:0002570)2.08205776
85Abnormal vertebral ossification (HP:0100569)2.07169322
86Biconcave vertebral bodies (HP:0004586)2.05485816
87Aortic dissection (HP:0002647)2.05108986
88Hepatocellular carcinoma (HP:0001402)2.04742254
89Irregular vertebral endplates (HP:0003301)2.02767295
90Vertebral compression fractures (HP:0002953)2.02712179
91Hyperglycinemia (HP:0002154)2.01918225
92Enlarged epiphyses (HP:0010580)2.01638967
93Malnutrition (HP:0004395)2.01563935
94Abnormality of the proximal phalanges of the hand (HP:0009834)2.01466819
95Abdominal distention (HP:0003270)2.01120503
96Abnormality of serine family amino acid metabolism (HP:0010894)2.00912538
97Abnormality of glycine metabolism (HP:0010895)2.00912538
98Bifid tongue (HP:0010297)1.99461733
99Mild short stature (HP:0003502)1.98911605
100Ileus (HP:0002595)1.98788531
101Increased serum pyruvate (HP:0003542)1.98700842
102Blue sclerae (HP:0000592)1.95425328
103Follicular hyperkeratosis (HP:0007502)1.95194074
104Right ventricular cardiomyopathy (HP:0011663)1.95187321
105Asymmetry of the thorax (HP:0001555)1.95011220
106Spinal cord compression (HP:0002176)1.94973840
107Skin nodule (HP:0200036)1.94573878
108Osteolytic defects of the phalanges of the hand (HP:0009771)1.93813669
109Osteolytic defects of the hand bones (HP:0009699)1.93813669
110Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.93531686
111Abnormality of femoral epiphyses (HP:0006499)1.93531686
112Pterygium (HP:0001059)1.93433637
113Abnormality of the distal phalanges of the toes (HP:0010182)1.93380217
114Mesomelia (HP:0003027)1.93200848
115Abnormality of the lumbar spine (HP:0100712)1.91709402
116Proximal tubulopathy (HP:0000114)1.89360924
117Ulnar bowing (HP:0003031)1.87927098
118Ketosis (HP:0001946)1.87341660
119Abnormality of pyrimidine metabolism (HP:0004353)1.86544380
120Abnormality of nucleobase metabolism (HP:0010932)1.83835361
121Mitral stenosis (HP:0001718)1.83466552
122Sex reversal (HP:0012245)1.80445422
123Abnormal sex determination (HP:0012244)1.80445422
124Renal duplication (HP:0000075)1.78119494
125Abnormality of the nasal septum (HP:0000419)1.77524475
126Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75300381
127Ankle contracture (HP:0006466)1.74736295
128Abnormal protein N-linked glycosylation (HP:0012347)1.73788814
129Abnormal protein glycosylation (HP:0012346)1.73788814
130Abnormal glycosylation (HP:0012345)1.73788814
131Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73788814
132Back pain (HP:0003418)1.73421838
133Short nail (HP:0001799)1.71788602
134Type I transferrin isoform profile (HP:0003642)1.70201792
135Hypophosphatemic rickets (HP:0004912)1.59154609
136Abnormality of the umbilical cord (HP:0010881)1.58888999
137Focal segmental glomerulosclerosis (HP:0000097)1.57879057
138Glomerulosclerosis (HP:0000096)1.54497201
139Wormian bones (HP:0002645)1.54225926
140Rickets (HP:0002748)1.52254230
141Short humerus (HP:0005792)1.52018961
142Abnormality of vitamin metabolism (HP:0100508)1.51498746
143Exocrine pancreatic insufficiency (HP:0001738)1.51104587
144Spondylolisthesis (HP:0003302)1.50972618
145Nephritis (HP:0000123)1.50325759
146Stenosis of the external auditory canal (HP:0000402)1.50291128
147Fibular aplasia (HP:0002990)1.46391318
148Aplasia/hypoplasia of the humerus (HP:0006507)1.46160789
149Coronal craniosynostosis (HP:0004440)1.43333233
150Abnormality of serum amino acid levels (HP:0003112)1.42887940
151Hypothermia (HP:0002045)1.42696984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.15383063
2MAP3K33.67340915
3ERN13.29439863
4STK38L3.24402376
5EIF2AK33.19403677
6LATS12.85204527
7FRK2.80537468
8SIK12.80316394
9EIF2AK12.60463136
10MST1R2.46762094
11TRIB32.46709389
12EPHA22.35513795
13MAP3K122.33587451
14ERBB42.33449927
15BCKDK2.23733689
16NUAK12.08056614
17TRIM282.05408320
18NEK12.02802548
19PRKG22.00286801
20TESK11.99673986
21PKN21.94252278
22BCR1.92998908
23PTK61.75486445
24FGFR41.75390847
25NEK91.72017534
26MST41.65251997
27PDGFRA1.61851726
28TTN1.56720477
29PBK1.56008560
30SCYL21.55979208
31EPHB21.46458971
32SRPK11.46389737
33MET1.42698548
34PIK3CG1.42696513
35TTK1.42366423
36RIPK11.42030551
37STK391.41511472
38TSSK61.40118335
39STK31.37701369
40PTK21.34621194
41LATS21.29272596
42ERBB31.28714961
43PLK31.28363893
44PIM21.27263071
45TRPM71.26621774
46BUB11.25907840
47PIK3CA1.24768530
48RPS6KA41.20878272
49STK241.16840605
50FER1.16587703
51TAOK21.13940034
52STK101.11690123
53EPHA31.10943897
54CDK81.10884812
55LIMK11.08402783
56MAP2K11.08323498
57CDK61.02901527
58MKNK11.02891020
59TAF11.00389668
60ACVR1B1.00131143
61PAK20.99340506
62VRK20.97886129
63FLT30.96880652
64GRK10.93811675
65MKNK20.92507165
66MAP2K30.91724074
67MAP3K100.91639130
68BRSK10.91181566
69ERBB20.91088259
70TGFBR20.89417793
71LRRK20.88591516
72AKT30.86769895
73PAK30.86093411
74ABL20.85709980
75MELK0.83303014
76BMX0.82290322
77PAK40.81893272
78NME10.79393267
79WEE10.78907419
80MAP2K20.77413918
81KDR0.76545386
82ROCK10.75828806
83PRKCE0.73952932
84MAP3K110.73210612
85MAPK110.72577299
86EIF2AK20.71576829
87TESK20.70596590
88BMPR1B0.70258156
89MYLK0.69147588
90MAP3K90.65891381
91GSK3A0.65710347
92MAP3K140.65132614
93IRAK30.64717670
94MAP4K20.64328182
95TBK10.64278942
96TAOK10.63575803
97NME20.62196501
98ILK0.60344781
99EPHB10.59932129
100DYRK1B0.59340084
101MAP3K20.58923714
102PRKAA20.58661183
103FGFR10.57604056
104PLK10.57081454
105CSK0.56958029
106WNK40.56922107
107PDGFRB0.56913652
108STK160.54562845
109NEK60.54416306
110MAP3K80.53896310
111INSRR0.52964855
112CDK70.52879158
113TAOK30.51652278
114MAP3K50.49658054
115MTOR0.49130463
116CDK90.48252012
117TYK20.47048932
118AURKB0.46841301
119MUSK0.45567622
120MAP3K70.45361965
121FGFR30.44807262
122MOS0.44759051
123ZAK0.44227972
124PLK20.42811070
125MAPKAPK30.40943381
126IGF1R0.40851449
127JAK10.39991654
128MAPK40.38560869
129PDK20.37112735
130WNK30.35645134
131SIK30.35024129
132CAMK2D0.34064137
133CSNK1E0.33845586
134TNIK0.33814229
135CHEK20.32732800
136BRSK20.31986052
137CHUK0.31983430
138DAPK10.31038889
139PRKCI0.31003453
140INSR0.30852586
141ABL10.30438731
142STK380.30405213
143RPS6KB20.27319435
144CSNK1G10.26077768
145MAPK150.24240309
146LMTK20.24163097
147PRKACG0.23065267
148JAK20.21041085
149SRC0.21037373

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.69250571
2* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.59530673
3* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.88558672
4Nitrogen metabolism_Homo sapiens_hsa009102.77770970
5Sulfur metabolism_Homo sapiens_hsa009202.59685900
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.49677918
7Tryptophan metabolism_Homo sapiens_hsa003802.42463289
8Arginine biosynthesis_Homo sapiens_hsa002202.40769885
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.39736892
10Chemical carcinogenesis_Homo sapiens_hsa052042.39491298
11Complement and coagulation cascades_Homo sapiens_hsa046102.37044986
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.26982550
13Caffeine metabolism_Homo sapiens_hsa002322.19415183
14Fatty acid degradation_Homo sapiens_hsa000712.19152490
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.09023153
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06613485
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98649489
18Retinol metabolism_Homo sapiens_hsa008301.89573345
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88524300
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86500400
21Butanoate metabolism_Homo sapiens_hsa006501.83392931
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.81345203
23* Starch and sucrose metabolism_Homo sapiens_hsa005001.77027478
24Protein export_Homo sapiens_hsa030601.75740274
25Histidine metabolism_Homo sapiens_hsa003401.74028250
26Selenocompound metabolism_Homo sapiens_hsa004501.72904189
27PPAR signaling pathway_Homo sapiens_hsa033201.72230168
28Peroxisome_Homo sapiens_hsa041461.69047531
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65709489
30Fat digestion and absorption_Homo sapiens_hsa049751.51491338
31Proteasome_Homo sapiens_hsa030501.49702339
32Bile secretion_Homo sapiens_hsa049761.48907821
33Steroid biosynthesis_Homo sapiens_hsa001001.41827522
34Glutathione metabolism_Homo sapiens_hsa004801.40981539
35Folate biosynthesis_Homo sapiens_hsa007901.39146402
36Fatty acid metabolism_Homo sapiens_hsa012121.38284125
37beta-Alanine metabolism_Homo sapiens_hsa004101.36801832
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33582439
39Propanoate metabolism_Homo sapiens_hsa006401.33278015
40Pancreatic secretion_Homo sapiens_hsa049721.33180006
41Staphylococcus aureus infection_Homo sapiens_hsa051501.30579866
42Vitamin digestion and absorption_Homo sapiens_hsa049771.28428264
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28073550
44Phenylalanine metabolism_Homo sapiens_hsa003601.24764616
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24318319
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23501023
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15616369
48Tyrosine metabolism_Homo sapiens_hsa003501.11462824
49ECM-receptor interaction_Homo sapiens_hsa045121.10462289
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09708258
51Pyruvate metabolism_Homo sapiens_hsa006201.06695836
52Protein digestion and absorption_Homo sapiens_hsa049741.05967167
53N-Glycan biosynthesis_Homo sapiens_hsa005101.05067408
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04756013
55Carbon metabolism_Homo sapiens_hsa012001.03826461
56Sulfur relay system_Homo sapiens_hsa041221.03134552
57Arginine and proline metabolism_Homo sapiens_hsa003301.02134492
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01808470
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.01575957
60Galactose metabolism_Homo sapiens_hsa000520.99500855
61Biosynthesis of amino acids_Homo sapiens_hsa012300.98297832
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98166995
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.92610390
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86802449
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86178215
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86083644
67One carbon pool by folate_Homo sapiens_hsa006700.85631607
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.83998266
69ABC transporters_Homo sapiens_hsa020100.78238599
70Lysine degradation_Homo sapiens_hsa003100.76747631
71* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73909176
72Tight junction_Homo sapiens_hsa045300.68951664
73Hippo signaling pathway_Homo sapiens_hsa043900.64117760
74Mineral absorption_Homo sapiens_hsa049780.63415628
75Non-homologous end-joining_Homo sapiens_hsa034500.58910886
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55705092
77Pentose phosphate pathway_Homo sapiens_hsa000300.55094505
78Fatty acid elongation_Homo sapiens_hsa000620.50120897
79Linoleic acid metabolism_Homo sapiens_hsa005910.49925077
80Glycerolipid metabolism_Homo sapiens_hsa005610.48635500
81Thyroid cancer_Homo sapiens_hsa052160.48044003
82Renin-angiotensin system_Homo sapiens_hsa046140.47129440
83Fructose and mannose metabolism_Homo sapiens_hsa000510.46602041
84Bladder cancer_Homo sapiens_hsa052190.46574127
85Sphingolipid metabolism_Homo sapiens_hsa006000.45386736
86Vibrio cholerae infection_Homo sapiens_hsa051100.42109176
87Focal adhesion_Homo sapiens_hsa045100.41941904
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37596769
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37221911
90RNA transport_Homo sapiens_hsa030130.36550911
91* Metabolic pathways_Homo sapiens_hsa011000.35342799
92Malaria_Homo sapiens_hsa051440.35014168
93RNA polymerase_Homo sapiens_hsa030200.33917079
94Pyrimidine metabolism_Homo sapiens_hsa002400.33694859
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32685407
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29437637
97TGF-beta signaling pathway_Homo sapiens_hsa043500.29284428
98Insulin resistance_Homo sapiens_hsa049310.27483171
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27189382
100Adherens junction_Homo sapiens_hsa045200.26427659
101Proteoglycans in cancer_Homo sapiens_hsa052050.25843927
102Amoebiasis_Homo sapiens_hsa051460.23620767
103Prion diseases_Homo sapiens_hsa050200.22024423
104Arachidonic acid metabolism_Homo sapiens_hsa005900.15018793
105Fatty acid biosynthesis_Homo sapiens_hsa000610.13264281
106Vitamin B6 metabolism_Homo sapiens_hsa007500.09785395
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.08782613
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08746789
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08663915
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07817493
111Small cell lung cancer_Homo sapiens_hsa052220.07564619
112Legionellosis_Homo sapiens_hsa051340.06256955
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06015092
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.05737788
115Ovarian steroidogenesis_Homo sapiens_hsa049130.04596730
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.03930404
117TNF signaling pathway_Homo sapiens_hsa046680.03692826
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.01740234

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