UGGT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.28777975
2neuron cell-cell adhesion (GO:0007158)3.91310368
3presynaptic membrane organization (GO:0097090)3.83502218
4ionotropic glutamate receptor signaling pathway (GO:0035235)3.82290302
5postsynaptic membrane organization (GO:0001941)3.71421898
6vocalization behavior (GO:0071625)3.58569382
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.57715838
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.51158717
9glutamate receptor signaling pathway (GO:0007215)3.48274990
10behavioral response to nicotine (GO:0035095)3.47127513
11synaptic transmission, glutamatergic (GO:0035249)3.42533860
12startle response (GO:0001964)3.41803263
13neuron recognition (GO:0008038)3.38980298
14response to pheromone (GO:0019236)3.32903330
15detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.31008551
16negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29672332
17transmission of nerve impulse (GO:0019226)3.29045691
18righting reflex (GO:0060013)3.24219191
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.17544085
20neuron-neuron synaptic transmission (GO:0007270)3.15668591
21kynurenine metabolic process (GO:0070189)3.12543178
22protein localization to synapse (GO:0035418)3.12314631
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11150173
24neural tube formation (GO:0001841)3.08838480
25regulation of glutamate receptor signaling pathway (GO:1900449)3.08081606
26cilium morphogenesis (GO:0060271)3.07521871
27regulation of timing of cell differentiation (GO:0048505)3.06317513
28tryptophan catabolic process (GO:0006569)3.05921501
29indole-containing compound catabolic process (GO:0042436)3.05921501
30indolalkylamine catabolic process (GO:0046218)3.05921501
31cerebral cortex radially oriented cell migration (GO:0021799)3.04756254
32axonal fasciculation (GO:0007413)3.03115953
33G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01272387
34dendritic spine morphogenesis (GO:0060997)2.99998479
35central nervous system projection neuron axonogenesis (GO:0021952)2.99668038
36cilium organization (GO:0044782)2.99259747
37nonmotile primary cilium assembly (GO:0035058)2.96706685
38cilium assembly (GO:0042384)2.95772356
39signal peptide processing (GO:0006465)2.95205856
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95010868
41limb bud formation (GO:0060174)2.94444906
42gamma-aminobutyric acid signaling pathway (GO:0007214)2.92058516
43protein K11-linked deubiquitination (GO:0035871)2.91026875
44protein prenylation (GO:0018342)2.90360080
45prenylation (GO:0097354)2.90360080
46negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90292524
47indolalkylamine metabolic process (GO:0006586)2.89932974
48photoreceptor cell maintenance (GO:0045494)2.88672442
49L-fucose catabolic process (GO:0042355)2.87627688
50fucose catabolic process (GO:0019317)2.87627688
51L-fucose metabolic process (GO:0042354)2.87627688
52regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.86828296
53cellular ketone body metabolic process (GO:0046950)2.86508120
54regulation of hippo signaling (GO:0035330)2.80958387
55epithelial cilium movement (GO:0003351)2.80645763
56regulation of synapse assembly (GO:0051963)2.80372751
57intraciliary transport (GO:0042073)2.79787891
58positive regulation of synapse assembly (GO:0051965)2.78109071
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77693258
60calcium ion import (GO:0070509)2.76475226
61inner ear receptor stereocilium organization (GO:0060122)2.70863095
62replication fork processing (GO:0031297)2.69947487
63L-amino acid import (GO:0043092)2.69342068
64DNA double-strand break processing (GO:0000729)2.69233961
65cerebellar Purkinje cell differentiation (GO:0021702)2.67834589
66behavioral response to ethanol (GO:0048149)2.65541842
67negative regulation of cytosolic calcium ion concentration (GO:0051481)2.65371846
68ketone body metabolic process (GO:1902224)2.63283143
69establishment of protein localization to Golgi (GO:0072600)2.62825369
70regulation of development, heterochronic (GO:0040034)2.61966796
71neuronal action potential propagation (GO:0019227)2.61921732
72regulation of synaptic transmission, glutamatergic (GO:0051966)2.61686946
73dendrite morphogenesis (GO:0048813)2.60948352
74positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60603224
75sequestering of extracellular ligand from receptor (GO:0035581)2.60192223
76pyrimidine nucleobase catabolic process (GO:0006208)2.59801222
77reflex (GO:0060004)2.59269309
78synaptic vesicle endocytosis (GO:0048488)2.58763224
79detection of light stimulus involved in sensory perception (GO:0050962)2.58150997
80detection of light stimulus involved in visual perception (GO:0050908)2.58150997
81neuronal ion channel clustering (GO:0045161)2.57628923
82retinal cone cell development (GO:0046549)2.57150002
83platelet dense granule organization (GO:0060155)2.56823361
84cranial nerve morphogenesis (GO:0021602)2.55470689
85dorsal/ventral axis specification (GO:0009950)2.54810356
86detection of calcium ion (GO:0005513)2.54728426
87tryptophan metabolic process (GO:0006568)2.54438700
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53728205
89central nervous system neuron axonogenesis (GO:0021955)2.53584683
90neurotransmitter-gated ion channel clustering (GO:0072578)2.52943345
91synapse assembly (GO:0007416)2.52812696
92mesenchymal cell differentiation involved in kidney development (GO:0072161)2.51962639
93mesenchymal cell differentiation involved in renal system development (GO:2001012)2.51962639
94auditory behavior (GO:0031223)2.51763682
95protein polyglutamylation (GO:0018095)2.51315667
96UDP-N-acetylglucosamine metabolic process (GO:0006047)2.50871836
97nephron epithelium morphogenesis (GO:0072088)2.50391594
98nephron tubule morphogenesis (GO:0072078)2.50391594
99cilium movement (GO:0003341)2.50267316
100protein localization to cilium (GO:0061512)2.49042444
101regulation of respiratory gaseous exchange (GO:0043576)2.49026015
102calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.48130074
103regulation of respiratory system process (GO:0044065)2.47892015
104regulation of glucokinase activity (GO:0033131)2.47626197
105regulation of hexokinase activity (GO:1903299)2.47626197
106cochlea development (GO:0090102)2.47461043
107water-soluble vitamin biosynthetic process (GO:0042364)2.46706294
108regulation of excitatory postsynaptic membrane potential (GO:0060079)2.46642989
109cyclic nucleotide catabolic process (GO:0009214)2.46357494
110positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.44212822
111locomotory exploration behavior (GO:0035641)2.44055077
112regulation of postsynaptic membrane potential (GO:0060078)2.42356896
113G-protein coupled receptor internalization (GO:0002031)2.42324315
114cAMP catabolic process (GO:0006198)2.41855874
115serotonin receptor signaling pathway (GO:0007210)2.41131815
116kidney morphogenesis (GO:0060993)2.41074552
117cellular component assembly involved in morphogenesis (GO:0010927)2.40859976
118artery development (GO:0060840)2.40630924
119response to auditory stimulus (GO:0010996)2.40499139
120inner ear receptor cell development (GO:0060119)2.40311851
121dendritic spine organization (GO:0097061)2.39436105
122regulation of synapse maturation (GO:0090128)2.39195785
123extracellular regulation of signal transduction (GO:1900115)2.38562551
124extracellular negative regulation of signal transduction (GO:1900116)2.38562551
125L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.38422504
126detection of mechanical stimulus involved in sensory perception (GO:0050974)2.38410560
127mechanosensory behavior (GO:0007638)2.37524049
128renal tubule morphogenesis (GO:0061333)2.37519466
129long-term memory (GO:0007616)2.37313967
130positive regulation of CREB transcription factor activity (GO:0032793)2.35925112
131sulfation (GO:0051923)2.35764654
132negative regulation of mast cell activation (GO:0033004)2.35689187
133adult walking behavior (GO:0007628)2.35405290
134regulation of synapse organization (GO:0050807)2.35396451
135retina layer formation (GO:0010842)2.35054171
136membrane depolarization during action potential (GO:0086010)2.34736472
137recombinational repair (GO:0000725)2.34168717
138regulation of establishment of cell polarity (GO:2000114)2.34072312
139nucleobase catabolic process (GO:0046113)2.33539138
140regulation of mesoderm development (GO:2000380)2.33350887
141proline transport (GO:0015824)2.33175741
142reciprocal DNA recombination (GO:0035825)2.33004592
143reciprocal meiotic recombination (GO:0007131)2.33004592
144double-strand break repair via homologous recombination (GO:0000724)2.32982831
145C4-dicarboxylate transport (GO:0015740)2.32775197
146regulation of synaptic transmission, GABAergic (GO:0032228)2.32742761
147regulation of sarcomere organization (GO:0060297)2.32588246
148cerebellar granule cell differentiation (GO:0021707)2.31169307
149negative regulation of neurotransmitter transport (GO:0051589)2.30043686
150dendrite development (GO:0016358)2.29728353
151cilium or flagellum-dependent cell motility (GO:0001539)2.29577568
152auditory receptor cell stereocilium organization (GO:0060088)2.29320176
153mesenchymal cell differentiation (GO:0048762)2.29042417
154negative regulation of osteoblast proliferation (GO:0033689)2.28215888
155regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.28017976
156photoreceptor cell development (GO:0042461)2.27864636
157positive regulation of dendritic spine morphogenesis (GO:0061003)2.27607406
158regulation of neuronal synaptic plasticity (GO:0048168)2.27581560
159axoneme assembly (GO:0035082)2.27326532
160cellular response to sterol (GO:0036315)2.26437639
161innervation (GO:0060384)2.26171549
162centriole replication (GO:0007099)2.26160280
163smoothened signaling pathway (GO:0007224)2.26090120
164regulation of synaptic vesicle exocytosis (GO:2000300)2.25287960
165membrane depolarization (GO:0051899)2.25075429
166regulation of non-canonical Wnt signaling pathway (GO:2000050)2.24882851
167spinal cord motor neuron differentiation (GO:0021522)2.24510845
168cranial nerve structural organization (GO:0021604)2.24470404
169cAMP-mediated signaling (GO:0019933)2.24424969
170appendage development (GO:0048736)2.24010928
171limb development (GO:0060173)2.24010928
172gamma-aminobutyric acid transport (GO:0015812)2.23540324
173regulation of action potential (GO:0098900)2.21758957
174retinal ganglion cell axon guidance (GO:0031290)2.21655042
175regulation of centriole replication (GO:0046599)2.21420973
176indole-containing compound metabolic process (GO:0042430)2.21345803
177regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.21299536
178anterograde synaptic vesicle transport (GO:0048490)2.20948096
179peristalsis (GO:0030432)2.20697091
180resolution of meiotic recombination intermediates (GO:0000712)2.20442851
181negative regulation of axon guidance (GO:1902668)2.20399593
182microtubule anchoring (GO:0034453)2.17943085
183magnesium ion transport (GO:0015693)2.17782366
184atrial cardiac muscle cell action potential (GO:0086014)2.16565557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.10170584
2GBX2_23144817_ChIP-Seq_PC3_Human4.01544799
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.68362044
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66791247
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45431881
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43291567
7* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38139918
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.34781485
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.29614526
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29024908
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24014570
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19469089
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10262881
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10262881
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01083858
16TAF15_26573619_Chip-Seq_HEK293_Human2.00837852
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00563048
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99588194
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.99108034
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98997922
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95210437
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92950443
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91326465
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89966501
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87739097
26IGF1R_20145208_ChIP-Seq_DFB_Human1.87041088
27P300_19829295_ChIP-Seq_ESCs_Human1.83262368
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81785464
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78469457
30* RNF2_27304074_Chip-Seq_ESCs_Mouse1.76935915
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.76793082
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75303972
33SMAD4_21799915_ChIP-Seq_A2780_Human1.74270410
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73751809
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73256156
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.73150082
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.70918913
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68460335
39FUS_26573619_Chip-Seq_HEK293_Human1.68115355
40DROSHA_22980978_ChIP-Seq_HELA_Human1.66417717
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.66245597
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61472571
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60872171
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.60497552
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60103229
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58837790
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56655690
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.55556324
49RNF2_27304074_Chip-Seq_NSC_Mouse1.54906724
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54692509
51BCAT_22108803_ChIP-Seq_LS180_Human1.54019473
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52601413
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51057746
54AR_21572438_ChIP-Seq_LNCaP_Human1.49746813
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49615576
56REST_21632747_ChIP-Seq_MESCs_Mouse1.47789605
57* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47336406
58* CBP_20019798_ChIP-Seq_JUKART_Human1.47336406
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45826169
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45238774
61VDR_22108803_ChIP-Seq_LS180_Human1.44851026
62STAT3_23295773_ChIP-Seq_U87_Human1.44391756
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.44320274
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43451591
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.42781932
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41026808
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39643987
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39248254
69P53_22387025_ChIP-Seq_ESCs_Mouse1.37105721
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36012721
71ER_23166858_ChIP-Seq_MCF-7_Human1.34183900
72TCF4_22108803_ChIP-Seq_LS180_Human1.33686248
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.31899548
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31802695
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.31239607
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31201473
77TP53_18474530_ChIP-ChIP_U2OS_Human1.31153406
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30979599
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30964066
80* TCF4_23295773_ChIP-Seq_U87_Human1.30773501
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29358469
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28709881
83* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26324110
84* AR_25329375_ChIP-Seq_VCAP_Human1.25756214
85TP53_16413492_ChIP-PET_HCT116_Human1.25722905
86RUNX2_22187159_ChIP-Seq_PCA_Human1.24858758
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24847941
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24354302
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24181540
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24181540
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.24177197
92ZNF274_21170338_ChIP-Seq_K562_Hela1.23658340
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23449491
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.22508124
95P300_18555785_Chip-Seq_ESCs_Mouse1.21489651
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21189030
97* EWS_26573619_Chip-Seq_HEK293_Human1.20821513
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20787234
99* FLI1_21867929_ChIP-Seq_TH2_Mouse1.19902018
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.19313317
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.19019422
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17723615
103AHR_22903824_ChIP-Seq_MCF-7_Human1.17271566
104FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16179030
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.15359014
106CJUN_26792858_Chip-Seq_BT549_Human1.14920601
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.14821107
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.14579153
109* SOX2_19829295_ChIP-Seq_ESCs_Human1.14547888
110* NANOG_19829295_ChIP-Seq_ESCs_Human1.14547888
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13640831
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13640831
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13623704
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13002846
115IRF1_19129219_ChIP-ChIP_H3396_Human1.11165973
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10986349
117KDM2B_26808549_Chip-Seq_REH_Human1.10435940
118HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10342412
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10207055
120RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10075873
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10067915
122* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09428875
123OCT4_18555785_Chip-Seq_ESCs_Mouse1.08893645
124IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07790649
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07472835
126CDX2_22108803_ChIP-Seq_LS180_Human1.07036622
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06835258
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06213772
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06117620
130JUN_21703547_ChIP-Seq_K562_Human1.05893374
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05691337
132TAL1_26923725_Chip-Seq_HPCs_Mouse1.05223435
133TP53_22573176_ChIP-Seq_HFKS_Human1.03539833

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.44260613
2MP0004859_abnormal_synaptic_plasticity3.19063640
3MP0001188_hyperpigmentation2.95825656
4MP0002102_abnormal_ear_morphology2.56911822
5MP0001486_abnormal_startle_reflex2.40019738
6MP0003635_abnormal_synaptic_transmissio2.37997228
7MP0005171_absent_coat_pigmentation2.31899775
8MP0009745_abnormal_behavioral_response2.23334003
9MP0000566_synostosis2.20698585
10MP0001968_abnormal_touch/_nociception2.18565316
11MP0003787_abnormal_imprinting2.16454703
12MP0006292_abnormal_olfactory_placode2.09359878
13MP0003136_yellow_coat_color2.05665671
14MP0009046_muscle_twitch2.02867625
15MP0000569_abnormal_digit_pigmentation1.98478208
16MP0005646_abnormal_pituitary_gland1.97841707
17MP0003195_calcinosis1.96476497
18MP0002736_abnormal_nociception_after1.95791683
19MP0002572_abnormal_emotion/affect_behav1.94812136
20MP0005645_abnormal_hypothalamus_physiol1.93538108
21MP0002063_abnormal_learning/memory/cond1.92073261
22MP0000427_abnormal_hair_cycle1.91095237
23MP0002735_abnormal_chemical_nociception1.87631648
24MP0005409_darkened_coat_color1.82619946
25MP0002272_abnormal_nervous_system1.81415163
26MP0003890_abnormal_embryonic-extraembry1.80706343
27MP0000778_abnormal_nervous_system1.80661268
28MP0002064_seizures1.77906877
29MP0001440_abnormal_grooming_behavior1.73206466
30MP0010386_abnormal_urinary_bladder1.69514875
31MP0003122_maternal_imprinting1.68725348
32MP0004270_analgesia1.67497196
33MP0005423_abnormal_somatic_nervous1.66394848
34MP0002067_abnormal_sensory_capabilities1.65623353
35MP0000383_abnormal_hair_follicle1.64932829
36MP0004742_abnormal_vestibular_system1.64751408
37MP0006276_abnormal_autonomic_nervous1.64642266
38MP0002837_dystrophic_cardiac_calcinosis1.62556760
39MP0005503_abnormal_tendon_morphology1.62068810
40MP0001501_abnormal_sleep_pattern1.62014501
41MP0002734_abnormal_mechanical_nocicepti1.61274569
42MP0002234_abnormal_pharynx_morphology1.58629972
43MP0002557_abnormal_social/conspecific_i1.54808143
44MP0009250_abnormal_appendicular_skeleto1.51704602
45MP0006054_spinal_hemorrhage1.51124794
46MP0002184_abnormal_innervation1.50016564
47MP0009780_abnormal_chondrocyte_physiolo1.47257181
48MP0001299_abnormal_eye_distance/1.47169380
49MP0004043_abnormal_pH_regulation1.44290993
50MP0002638_abnormal_pupillary_reflex1.42149612
51MP0004133_heterotaxia1.39783708
52MP0000631_abnormal_neuroendocrine_gland1.39144521
53MP0009697_abnormal_copulation1.39042043
54MP0006072_abnormal_retinal_apoptosis1.33515826
55MP0002928_abnormal_bile_duct1.33434751
56MP0005551_abnormal_eye_electrophysiolog1.33279331
57MP0001984_abnormal_olfaction1.30336888
58MP0000026_abnormal_inner_ear1.29699070
59MP0000372_irregular_coat_pigmentation1.26318211
60MP0002938_white_spotting1.25746478
61MP0004215_abnormal_myocardial_fiber1.25118062
62MP0003385_abnormal_body_wall1.22480759
63MP0000955_abnormal_spinal_cord1.20407559
64MP0005187_abnormal_penis_morphology1.20361259
65MP0010678_abnormal_skin_adnexa1.20124470
66MP0000049_abnormal_middle_ear1.19704713
67MP0005623_abnormal_meninges_morphology1.19503347
68MP0003121_genomic_imprinting1.17841162
69MP0000647_abnormal_sebaceous_gland1.16396413
70MP0003950_abnormal_plasma_membrane1.16032722
71MP0008877_abnormal_DNA_methylation1.15810289
72MP0002751_abnormal_autonomic_nervous1.15276185
73MP0001502_abnormal_circadian_rhythm1.14709476
74MP0001970_abnormal_pain_threshold1.13223876
75MP0005195_abnormal_posterior_eye1.12320031
76MP0005257_abnormal_intraocular_pressure1.11112972
77MP0001963_abnormal_hearing_physiology1.10072347
78MP0003119_abnormal_digestive_system1.09849917
79MP0005391_vision/eye_phenotype1.09668921
80MP0002882_abnormal_neuron_morphology1.09111011
81MP0004145_abnormal_muscle_electrophysio1.07401837
82MP0002090_abnormal_vision1.05475453
83MP0002249_abnormal_larynx_morphology1.05216977
84MP0004272_abnormal_basement_membrane1.03609834
85MP0002733_abnormal_thermal_nociception1.03481622
86MP0008057_abnormal_DNA_replication1.03448137
87MP0003937_abnormal_limbs/digits/tail_de1.03228670
88MP0003941_abnormal_skin_development1.02603599
89MP0002160_abnormal_reproductive_system1.01915709
90MP0001986_abnormal_taste_sensitivity1.01089553
91MP0003252_abnormal_bile_duct1.00826465
92MP0003718_maternal_effect1.00023002
93MP0003938_abnormal_ear_development0.99796908
94MP0001293_anophthalmia0.99497290
95MP0002282_abnormal_trachea_morphology0.99374782
96MP0002752_abnormal_somatic_nervous0.99173978
97MP0001177_atelectasis0.99116824
98MP0000538_abnormal_urinary_bladder0.98921716
99MP0005379_endocrine/exocrine_gland_phen0.97405919
100MP0005386_behavior/neurological_phenoty0.97280465
101MP0004924_abnormal_behavior0.97280465
102MP0004142_abnormal_muscle_tone0.97161776
103MP0002876_abnormal_thyroid_physiology0.97058527
104MP0002177_abnormal_outer_ear0.96239069
105MP0003283_abnormal_digestive_organ0.95713651
106MP0008775_abnormal_heart_ventricle0.95499379
107MP0005084_abnormal_gallbladder_morpholo0.95290587
108MP0004134_abnormal_chest_morphology0.94139266
109MP0000015_abnormal_ear_pigmentation0.94109976
110MP0005253_abnormal_eye_physiology0.93791769
111MP0003755_abnormal_palate_morphology0.93334919
112MP0001324_abnormal_eye_pigmentation0.93014748
113MP0002116_abnormal_craniofacial_bone0.90744323
114MP0002108_abnormal_muscle_morphology0.88963579
115MP0005367_renal/urinary_system_phenotyp0.88513218
116MP0000516_abnormal_urinary_system0.88513218
117MP0002233_abnormal_nose_morphology0.88417622
118MP0001485_abnormal_pinna_reflex0.88095811
119MP0003137_abnormal_impulse_conducting0.87807670
120MP0008569_lethality_at_weaning0.87707688
121MP0003011_delayed_dark_adaptation0.87587477
122MP0000579_abnormal_nail_morphology0.86238074
123MP0002066_abnormal_motor_capabilities/c0.85035148
124MP0003646_muscle_fatigue0.84720273
125MP0005275_abnormal_skin_tensile0.83411014
126MP0001346_abnormal_lacrimal_gland0.80222732
127MP0002152_abnormal_brain_morphology0.80046554
128MP0008058_abnormal_DNA_repair0.79641159
129MP0002909_abnormal_adrenal_gland0.78899976
130MP0001286_abnormal_eye_development0.78431296
131MP0002277_abnormal_respiratory_mucosa0.72711275
132MP0002109_abnormal_limb_morphology0.71933059
133MP0005508_abnormal_skeleton_morphology0.71102637
134MP0001905_abnormal_dopamine_level0.70521686
135MP0001529_abnormal_vocalization0.70163097
136MP0008438_abnormal_cutaneous_collagen0.69886336
137MP0004811_abnormal_neuron_physiology0.67742368
138MP0004885_abnormal_endolymph0.67363490
139MP0003935_abnormal_craniofacial_develop0.66851666
140MP0000163_abnormal_cartilage_morphology0.66361865
141MP0005248_abnormal_Harderian_gland0.65713512

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.16191833
2Febrile seizures (HP:0002373)4.44617910
3Pancreatic fibrosis (HP:0100732)4.31074303
4Pancreatic cysts (HP:0001737)4.21515496
5True hermaphroditism (HP:0010459)4.10739436
6Molar tooth sign on MRI (HP:0002419)3.69557459
7Abnormality of midbrain morphology (HP:0002418)3.69557459
8Chronic hepatic failure (HP:0100626)3.18589373
9Epileptic encephalopathy (HP:0200134)3.16524542
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.06968724
11Absent/shortened dynein arms (HP:0200106)3.06968724
12Abnormality of the renal cortex (HP:0011035)3.06771550
13Focal seizures (HP:0007359)2.92227363
14Aplasia/Hypoplasia of the tongue (HP:0010295)2.82760579
15Cystic liver disease (HP:0006706)2.82758176
16Septo-optic dysplasia (HP:0100842)2.78386763
17Nephrogenic diabetes insipidus (HP:0009806)2.76732245
18Tubulointerstitial nephritis (HP:0001970)2.75736724
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.68704752
20Genetic anticipation (HP:0003743)2.68173093
21Abnormal ciliary motility (HP:0012262)2.65458084
22Tubular atrophy (HP:0000092)2.59355311
23Renal cortical cysts (HP:0000803)2.57530148
24Aplasia involving bones of the upper limbs (HP:0009823)2.48254250
25Aplasia of the phalanges of the hand (HP:0009802)2.48254250
26Aplasia involving bones of the extremities (HP:0009825)2.48254250
27Attenuation of retinal blood vessels (HP:0007843)2.47428627
28Progressive cerebellar ataxia (HP:0002073)2.45729408
29Atonic seizures (HP:0010819)2.41698299
30Sclerocornea (HP:0000647)2.38391796
31Type II lissencephaly (HP:0007260)2.36309583
32Abnormality of incisor morphology (HP:0011063)2.35697273
33Broad-based gait (HP:0002136)2.35410566
34Abnormal respiratory motile cilium physiology (HP:0012261)2.34197121
35Large for gestational age (HP:0001520)2.32257111
36Postaxial foot polydactyly (HP:0001830)2.32157289
37Drooling (HP:0002307)2.31186411
38Excessive salivation (HP:0003781)2.31186411
39Poor coordination (HP:0002370)2.28516581
40Short tibia (HP:0005736)2.25951893
41Nephronophthisis (HP:0000090)2.22418407
42Hyperventilation (HP:0002883)2.21972860
43Cerebellar dysplasia (HP:0007033)2.19226944
44Cutaneous finger syndactyly (HP:0010554)2.18592293
45Furrowed tongue (HP:0000221)2.18514321
46Generalized tonic-clonic seizures (HP:0002069)2.17796333
47Protruding tongue (HP:0010808)2.17676349
48Postaxial hand polydactyly (HP:0001162)2.17451646
49Abnormality of the nasal septum (HP:0000419)2.16189924
50Congenital hepatic fibrosis (HP:0002612)2.15479488
51Abolished electroretinogram (ERG) (HP:0000550)2.15381157
52Aplasia cutis congenita (HP:0001057)2.14345233
53Optic nerve hypoplasia (HP:0000609)2.14261855
54Bell-shaped thorax (HP:0001591)2.14037381
55Abnormal respiratory epithelium morphology (HP:0012253)2.13036872
56Abnormal respiratory motile cilium morphology (HP:0005938)2.13036872
57Gaze-evoked nystagmus (HP:0000640)2.12694242
58Occipital encephalocele (HP:0002085)2.12367814
59Absent speech (HP:0001344)2.10931066
60Congenital sensorineural hearing impairment (HP:0008527)2.10511697
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10361594
62Anencephaly (HP:0002323)2.10283313
63Abnormal biliary tract physiology (HP:0012439)2.10282073
64Bile duct proliferation (HP:0001408)2.10282073
65Abnormality of the renal medulla (HP:0100957)2.10073607
66Mixed hearing impairment (HP:0000410)2.09239232
67Chorioretinal atrophy (HP:0000533)2.08268298
68Upper limb muscle weakness (HP:0003484)2.07465974
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.06637716
70Midline defect of the nose (HP:0004122)2.06579038
71Morphological abnormality of the middle ear (HP:0008609)2.06501051
72Lissencephaly (HP:0001339)2.03792441
73Medial flaring of the eyebrow (HP:0010747)2.02958663
74Short foot (HP:0001773)2.02053934
75Abnormality of the ischium (HP:0003174)2.01196701
76Abnormality of salivation (HP:0100755)2.01092709
77Aplasia/Hypoplasia of the lens (HP:0008063)1.99987078
78Astigmatism (HP:0000483)1.98313247
79Fibular hypoplasia (HP:0003038)1.97019062
80Median cleft lip (HP:0000161)1.95113781
81Decreased central vision (HP:0007663)1.94653305
82Osteomalacia (HP:0002749)1.94026691
83Hypoplastic labia majora (HP:0000059)1.93659658
84Widely spaced teeth (HP:0000687)1.93552589
85Progressive inability to walk (HP:0002505)1.93457216
86Preaxial foot polydactyly (HP:0001841)1.92927024
87Bradycardia (HP:0001662)1.89308691
88Cutaneous syndactyly (HP:0012725)1.88043511
89Volvulus (HP:0002580)1.87648959
90Male pseudohermaphroditism (HP:0000037)1.87603033
91Hypoplastic ischia (HP:0003175)1.84877040
92Bifid tongue (HP:0010297)1.83171671
93Inability to walk (HP:0002540)1.82958029
94Gastroesophageal reflux (HP:0002020)1.82058416
95Broad foot (HP:0001769)1.81955457
96Bony spicule pigmentary retinopathy (HP:0007737)1.81814746
97Dialeptic seizures (HP:0011146)1.81636533
98White forelock (HP:0002211)1.81492807
99Absent septum pellucidum (HP:0001331)1.80748256
100Absence seizures (HP:0002121)1.80689631
101Oligodactyly (hands) (HP:0001180)1.80647007
102Abnormality of dentin (HP:0010299)1.80623475
103Polydipsia (HP:0001959)1.80069684
104Abnormal drinking behavior (HP:0030082)1.80069684
105Abnormality of chromosome stability (HP:0003220)1.79156189
106Dandy-Walker malformation (HP:0001305)1.77998452
107Abnormality of the labia majora (HP:0012881)1.77609813
108Alacrima (HP:0000522)1.76991786
109Sloping forehead (HP:0000340)1.76725552
110Hemiparesis (HP:0001269)1.76336804
111Gastrointestinal atresia (HP:0002589)1.75897535
112Decreased lacrimation (HP:0000633)1.75289146
113Small hand (HP:0200055)1.74805925
114Abnormality of the parietal bone (HP:0002696)1.73604436
115Gait imbalance (HP:0002141)1.73526418
116Abnormality of the ileum (HP:0001549)1.73367989
117Hypoplasia of the fovea (HP:0007750)1.73233769
118Aplasia/Hypoplasia of the fovea (HP:0008060)1.73233769
119Narrow forehead (HP:0000341)1.73153717
120Tubulointerstitial abnormality (HP:0001969)1.72997183
121Blue irides (HP:0000635)1.71594305
122Omphalocele (HP:0001539)1.71151054
123Hyperglycinemia (HP:0002154)1.71050538
124Patchy hypopigmentation of hair (HP:0011365)1.69794534
125Preaxial hand polydactyly (HP:0001177)1.69526684
126Mesomelia (HP:0003027)1.69367430
127Generalized hypopigmentation of hair (HP:0011358)1.69279690
128Meckel diverticulum (HP:0002245)1.68452940
129Abnormality of the labia minora (HP:0012880)1.68148910
130Supernumerary spleens (HP:0009799)1.68062856
131Abnormality of molar (HP:0011077)1.67575875
132Abnormality of molar morphology (HP:0011070)1.67575875
133Increased corneal curvature (HP:0100692)1.67325435
134Keratoconus (HP:0000563)1.67325435
135Aganglionic megacolon (HP:0002251)1.66773528
136Cupped ear (HP:0000378)1.66550185
137Atelectasis (HP:0100750)1.66069917
138Conical tooth (HP:0000698)1.65811830
139Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65617085
140Chromsome breakage (HP:0040012)1.64878513
141Absent eyebrow (HP:0002223)1.64724681
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.64723097
143Congenital, generalized hypertrichosis (HP:0004540)1.64033947
144Delayed gross motor development (HP:0002194)1.63264424
145Long nose (HP:0003189)1.62107863
146Specific learning disability (HP:0001328)1.61635622
147Abnormality of alanine metabolism (HP:0010916)1.61626734
148Hyperalaninemia (HP:0003348)1.61626734
149Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61626734
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61235272
151Congenital stationary night blindness (HP:0007642)1.61064297
152Intestinal atresia (HP:0011100)1.60898002
153Hypothermia (HP:0002045)1.60735415
154Congenital primary aphakia (HP:0007707)1.59790153
155Genital tract atresia (HP:0001827)1.59273393
156Myokymia (HP:0002411)1.58610955
157Action tremor (HP:0002345)1.58098800
158Abnormality of the nasolacrimal system (HP:0000614)1.57010916
159Exotropia (HP:0000577)1.56223576
160Ectopic anus (HP:0004397)1.56131321
161Abnormality of the septum pellucidum (HP:0007375)1.56059034
162Vaginal atresia (HP:0000148)1.55927212
163Aplasia/Hypoplasia of the fibula (HP:0006492)1.55677363
164Fair hair (HP:0002286)1.54718398
165Myelomeningocele (HP:0002475)1.53633833
166Abnormal hair whorl (HP:0010721)1.53418263
167Hypoplasia of the iris (HP:0007676)1.53020527
168Abnormality of the fibula (HP:0002991)1.52749099
169Overfolded helix (HP:0000396)1.52710805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.70976797
2NTRK33.81130840
3TNIK3.47728748
4INSRR3.14545861
5EPHA42.75818553
6MAP4K22.67183296
7ACVR1B2.58389012
8MAP2K72.50917415
9SIK32.06672536
10MAP3K42.01629741
11MAPK131.86354309
12MARK11.82797608
13MKNK21.69571573
14NTRK21.61800955
15NUAK11.59012514
16TRIM281.57289909
17NEK61.46284143
18BCR1.42627067
19AKT31.34073487
20PLK21.31953512
21EIF2AK21.28828915
22BMPR21.27278464
23ZAK1.27071884
24CDK31.23703413
25DDR21.21923654
26PRPF4B1.21291237
27BMPR1B1.21166085
28STK161.17892897
29CAMK1G1.17694871
30YES11.14618865
31ERBB31.13478335
32PLK41.12089701
33EIF2AK31.11458456
34PKN11.11303939
35TGFBR11.10339301
36SGK21.09115084
37PRKCE1.08065255
38SIK21.07956617
39CSNK1G11.07114637
40PNCK1.06708350
41CSNK1G21.03439691
42CSNK1A1L1.02767355
43STK30.99485707
44CAMK2A0.97265386
45BRSK20.96149276
46SGK2230.95253161
47SGK4940.95253161
48FER0.94943185
49FES0.94610067
50MUSK0.93660653
51PIK3CA0.92297381
52IRAK10.92042640
53FLT30.90104076
54WEE10.90012475
55LATS10.89590447
56MINK10.89314077
57EPHB20.88818618
58PRKD30.88424386
59MET0.87839426
60CSNK1G30.87628156
61OXSR10.86362983
62MKNK10.86321835
63PLK30.84749731
64PAK60.84445576
65SGK10.83954788
66WNK10.82977935
67GRK10.82876321
68DYRK1A0.82104568
69GRK70.80964335
70BRD40.80525331
71STK390.80142889
72WNK30.80041167
73TIE10.78976018
74ADRBK20.75943277
75TLK10.75519648
76CDK50.75419591
77PRKCG0.75355975
78CAMK2B0.72248319
79CDC42BPA0.71639392
80CAMK2D0.70056333
81PAK30.69963591
82MARK20.68860486
83TNK20.67528366
84DAPK20.66602354
85KSR10.66584649
86IRAK20.62686291
87FRK0.62631831
88FGR0.61937715
89MAP2K40.59942554
90UHMK10.59525709
91CAMK1D0.58983186
92PRKG10.58653876
93STK380.58489657
94CAMK10.57344834
95VRK10.57111925
96MST40.56953178
97EPHA30.56799748
98FGFR20.56355091
99PRKD20.56083935
100FGFR10.54626280
101DMPK0.54591417
102GRK50.53596153
103NEK20.53512353
104CAMKK20.53491169
105MAPK150.53158741
106STK38L0.53122835
107TRPM70.51893918
108CDK80.51345124
109NTRK10.51109754
110MAP3K130.49063277
111DYRK20.48719125
112BLK0.48357815
113CHEK20.48038582
114TAOK30.46526807
115SGK30.45847766
116ATM0.44545055
117MYLK0.44499913
118ERBB40.44414480
119PHKG10.44197862
120PHKG20.44197862
121PLK10.44195661
122ADRBK10.43197397
123PINK10.43147422
124CSNK1D0.43139351
125RIPK40.42676378
126PTK2B0.42638573
127WNK40.41390502
128CDC70.40643114
129RPS6KB10.40362675
130PRKCH0.40264301
131PRKAA10.40113351
132PRKACA0.39946197
133MAPKAPK50.39583624
134MAPK70.39478031
135OBSCN0.38706102
136CCNB10.38656025
137PRKAA20.36555238
138NEK10.36547981
139PRKACB0.33118058
140PIK3CG0.33113501
141NEK90.32286008
142ERBB20.32054664
143BCKDK0.30253827
144CSNK1A10.28961312

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.78586683
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86218582
3Butanoate metabolism_Homo sapiens_hsa006502.45034739
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41170143
5Glutamatergic synapse_Homo sapiens_hsa047242.37088635
6Morphine addiction_Homo sapiens_hsa050322.35325101
7Circadian entrainment_Homo sapiens_hsa047132.22038681
8Selenocompound metabolism_Homo sapiens_hsa004502.14598963
9GABAergic synapse_Homo sapiens_hsa047272.12933108
10Taste transduction_Homo sapiens_hsa047422.07722137
11Propanoate metabolism_Homo sapiens_hsa006402.07698981
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.06092801
13Serotonergic synapse_Homo sapiens_hsa047262.00875635
14Insulin secretion_Homo sapiens_hsa049111.98655675
15Amphetamine addiction_Homo sapiens_hsa050311.91615548
16Homologous recombination_Homo sapiens_hsa034401.84444741
17Olfactory transduction_Homo sapiens_hsa047401.80086926
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79964644
19Nitrogen metabolism_Homo sapiens_hsa009101.77436169
20Phototransduction_Homo sapiens_hsa047441.77331896
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72685012
22Axon guidance_Homo sapiens_hsa043601.69473285
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.68890622
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65678468
25Tryptophan metabolism_Homo sapiens_hsa003801.64463067
26Long-term potentiation_Homo sapiens_hsa047201.61179837
27Cocaine addiction_Homo sapiens_hsa050301.60790539
28Basal transcription factors_Homo sapiens_hsa030221.58327218
29Long-term depression_Homo sapiens_hsa047301.58100277
30Calcium signaling pathway_Homo sapiens_hsa040201.57278430
31Dopaminergic synapse_Homo sapiens_hsa047281.56469271
32Non-homologous end-joining_Homo sapiens_hsa034501.56347140
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55558727
34Synaptic vesicle cycle_Homo sapiens_hsa047211.55498023
35Salivary secretion_Homo sapiens_hsa049701.54947910
36Cholinergic synapse_Homo sapiens_hsa047251.51724966
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50438188
38ABC transporters_Homo sapiens_hsa020101.47158602
39Renin secretion_Homo sapiens_hsa049241.39264578
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36953158
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36413687
42cAMP signaling pathway_Homo sapiens_hsa040241.32130362
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30838760
44Oxytocin signaling pathway_Homo sapiens_hsa049211.22083809
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21298083
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.20819378
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20614314
48Steroid biosynthesis_Homo sapiens_hsa001001.17193794
49Peroxisome_Homo sapiens_hsa041461.16248234
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11145298
51Gastric acid secretion_Homo sapiens_hsa049711.10718212
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10385972
53Type II diabetes mellitus_Homo sapiens_hsa049301.10383152
54Dilated cardiomyopathy_Homo sapiens_hsa054141.06944885
55Ether lipid metabolism_Homo sapiens_hsa005651.06930566
56One carbon pool by folate_Homo sapiens_hsa006701.05977286
57beta-Alanine metabolism_Homo sapiens_hsa004101.03535671
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02736667
59Melanogenesis_Homo sapiens_hsa049161.02688778
60Wnt signaling pathway_Homo sapiens_hsa043101.02601073
61Ovarian steroidogenesis_Homo sapiens_hsa049131.02414227
62Basal cell carcinoma_Homo sapiens_hsa052171.01093626
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00143387
64Sphingolipid metabolism_Homo sapiens_hsa006001.00113914
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99140030
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.98883504
67GnRH signaling pathway_Homo sapiens_hsa049120.97209602
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96891803
69Hedgehog signaling pathway_Homo sapiens_hsa043400.96610477
70Circadian rhythm_Homo sapiens_hsa047100.96152934
71Retinol metabolism_Homo sapiens_hsa008300.96061838
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95132192
73Chemical carcinogenesis_Homo sapiens_hsa052040.94853309
74TGF-beta signaling pathway_Homo sapiens_hsa043500.94494425
75ECM-receptor interaction_Homo sapiens_hsa045120.91035070
76RNA degradation_Homo sapiens_hsa030180.89369103
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88018729
78Ras signaling pathway_Homo sapiens_hsa040140.86955874
79Caffeine metabolism_Homo sapiens_hsa002320.86711200
80Sulfur metabolism_Homo sapiens_hsa009200.86637315
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85588428
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85516200
83ErbB signaling pathway_Homo sapiens_hsa040120.85373392
84Lysine degradation_Homo sapiens_hsa003100.85308245
85Dorso-ventral axis formation_Homo sapiens_hsa043200.83611861
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80632414
87Collecting duct acid secretion_Homo sapiens_hsa049660.80015172
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79875520
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78208924
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78076935
91MAPK signaling pathway_Homo sapiens_hsa040100.77753468
92Pancreatic secretion_Homo sapiens_hsa049720.77263672
93Gap junction_Homo sapiens_hsa045400.75609075
94Melanoma_Homo sapiens_hsa052180.74954393
95Fatty acid biosynthesis_Homo sapiens_hsa000610.73890781
96Histidine metabolism_Homo sapiens_hsa003400.73570320
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72822855
98Type I diabetes mellitus_Homo sapiens_hsa049400.72526154
99Fatty acid metabolism_Homo sapiens_hsa012120.71666148
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.70367425
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70274537
102Vibrio cholerae infection_Homo sapiens_hsa051100.70081327
103Fatty acid degradation_Homo sapiens_hsa000710.69889984
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.69564108
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69466541
106Choline metabolism in cancer_Homo sapiens_hsa052310.68583730
107Glycerolipid metabolism_Homo sapiens_hsa005610.68279654
108RNA polymerase_Homo sapiens_hsa030200.67307891
109Rheumatoid arthritis_Homo sapiens_hsa053230.67098937
110Fanconi anemia pathway_Homo sapiens_hsa034600.66273507
111Nucleotide excision repair_Homo sapiens_hsa034200.64527214
112Rap1 signaling pathway_Homo sapiens_hsa040150.64339757
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64282861
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64203331
115Estrogen signaling pathway_Homo sapiens_hsa049150.63981722
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63663245
117Autoimmune thyroid disease_Homo sapiens_hsa053200.63567179
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.61475008
119Protein digestion and absorption_Homo sapiens_hsa049740.59810348
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59687737
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59589124
122Metabolic pathways_Homo sapiens_hsa011000.57749133
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56546026
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53912156
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53550581
126Alcoholism_Homo sapiens_hsa050340.53377005
127Purine metabolism_Homo sapiens_hsa002300.53045487
128Inositol phosphate metabolism_Homo sapiens_hsa005620.52277417
129Oxidative phosphorylation_Homo sapiens_hsa001900.51957680
130Protein export_Homo sapiens_hsa030600.51926741
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51299741
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50232851
133Regulation of autophagy_Homo sapiens_hsa041400.50168217
134African trypanosomiasis_Homo sapiens_hsa051430.49857442
135Thyroid hormone synthesis_Homo sapiens_hsa049180.47845304
136Fat digestion and absorption_Homo sapiens_hsa049750.46813788
137Cardiac muscle contraction_Homo sapiens_hsa042600.45724252
138Arachidonic acid metabolism_Homo sapiens_hsa005900.44816664
139Glioma_Homo sapiens_hsa052140.44498908
140Arginine and proline metabolism_Homo sapiens_hsa003300.43778251
141Hippo signaling pathway_Homo sapiens_hsa043900.43521020
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43289900
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43198785
144Focal adhesion_Homo sapiens_hsa045100.42986083
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41517013
146Linoleic acid metabolism_Homo sapiens_hsa005910.41468092
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40071729
148Phagosome_Homo sapiens_hsa041450.39996117
149Mineral absorption_Homo sapiens_hsa049780.39218142
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39151815
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.38861637
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37945873
153Prostate cancer_Homo sapiens_hsa052150.33177518

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