UGP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.20593029
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.20593029
3L-phenylalanine metabolic process (GO:0006558)5.95688331
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.95688331
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.50766159
6establishment of integrated proviral latency (GO:0075713)5.47401846
7aromatic amino acid family catabolic process (GO:0009074)5.47154748
8alpha-linolenic acid metabolic process (GO:0036109)5.16400904
9glyoxylate metabolic process (GO:0046487)5.07273964
10kynurenine metabolic process (GO:0070189)4.90341567
11bile acid biosynthetic process (GO:0006699)4.90123378
12tryptophan catabolic process (GO:0006569)4.83188168
13indole-containing compound catabolic process (GO:0042436)4.83188168
14indolalkylamine catabolic process (GO:0046218)4.83188168
15L-serine metabolic process (GO:0006563)4.82285108
16regulation of gene silencing by RNA (GO:0060966)4.78780820
17regulation of posttranscriptional gene silencing (GO:0060147)4.78780820
18regulation of gene silencing by miRNA (GO:0060964)4.78780820
19sulfur amino acid catabolic process (GO:0000098)4.73217970
20IMP biosynthetic process (GO:0006188)4.72024065
21tyrosine metabolic process (GO:0006570)4.71687017
22lysine catabolic process (GO:0006554)4.66201134
23lysine metabolic process (GO:0006553)4.66201134
24cysteine metabolic process (GO:0006534)4.65967456
25IMP metabolic process (GO:0046040)4.59530635
26high-density lipoprotein particle remodeling (GO:0034375)4.59474264
27tryptophan metabolic process (GO:0006568)4.58861900
28protein carboxylation (GO:0018214)4.57393217
29peptidyl-glutamic acid carboxylation (GO:0017187)4.57393217
30urea cycle (GO:0000050)4.55445034
31urea metabolic process (GO:0019627)4.55445034
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.52563438
33regulation of protein activation cascade (GO:2000257)4.51284737
34negative regulation of fibrinolysis (GO:0051918)4.50764476
35complement activation, alternative pathway (GO:0006957)4.46206815
36homocysteine metabolic process (GO:0050667)4.36759754
37regulation of triglyceride catabolic process (GO:0010896)4.33706858
38chromatin remodeling at centromere (GO:0031055)4.32775534
39regulation of fibrinolysis (GO:0051917)4.32655609
40cellular ketone body metabolic process (GO:0046950)4.28666602
41regulation of complement activation (GO:0030449)4.27629149
42amino-acid betaine metabolic process (GO:0006577)4.20630354
43ketone body metabolic process (GO:1902224)4.20137861
44aromatic amino acid family metabolic process (GO:0009072)4.19663739
45reverse cholesterol transport (GO:0043691)4.19282844
46CENP-A containing nucleosome assembly (GO:0034080)4.18173242
47nitrogen cycle metabolic process (GO:0071941)4.17815582
48pre-miRNA processing (GO:0031054)4.16622225
49bile acid metabolic process (GO:0008206)4.15967636
50ribosome assembly (GO:0042255)4.15501052
51serine family amino acid catabolic process (GO:0009071)4.15423312
52mitotic metaphase plate congression (GO:0007080)4.12062110
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.11365722
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.11365722
55negative regulation of mitotic sister chromatid segregation (GO:0033048)4.11365722
56negative regulation of mitotic sister chromatid separation (GO:2000816)4.11365722
57negative regulation of sister chromatid segregation (GO:0033046)4.11365722
58regulation of helicase activity (GO:0051095)4.09959693
59short-chain fatty acid metabolic process (GO:0046459)4.08056813
60protein-lipid complex remodeling (GO:0034368)4.07805236
61macromolecular complex remodeling (GO:0034367)4.07805236
62plasma lipoprotein particle remodeling (GO:0034369)4.07805236
63protein localization to kinetochore (GO:0034501)4.07393439
64protein complex localization (GO:0031503)4.02791577
65anterior/posterior axis specification, embryo (GO:0008595)4.01877930
66alpha-amino acid catabolic process (GO:1901606)3.99540318
67regulation of cholesterol esterification (GO:0010872)3.99496087
68negative regulation of chromosome segregation (GO:0051985)3.97585413
69plasma lipoprotein particle clearance (GO:0034381)3.97488647
70positive regulation of SMAD protein import into nucleus (GO:0060391)3.97477722
71establishment of viral latency (GO:0019043)3.95994417
72acylglycerol homeostasis (GO:0055090)3.89803175
73triglyceride homeostasis (GO:0070328)3.89803175
74acetyl-CoA metabolic process (GO:0006084)3.81965046
75histone exchange (GO:0043486)3.79509665
76purine nucleobase biosynthetic process (GO:0009113)3.79315336
772-oxoglutarate metabolic process (GO:0006103)3.77937810
78cellular amino acid catabolic process (GO:0009063)3.77659802
79cellular modified amino acid catabolic process (GO:0042219)3.77400982
80phospholipid efflux (GO:0033700)3.77380926
81paraxial mesoderm development (GO:0048339)3.76548691
82* cellular glucuronidation (GO:0052695)3.75146403
83dicarboxylic acid biosynthetic process (GO:0043650)3.74090629
84glutamate metabolic process (GO:0006536)3.74056442
85ethanol oxidation (GO:0006069)3.73696004
86fatty acid beta-oxidation (GO:0006635)3.71234676
87coenzyme catabolic process (GO:0009109)3.70826667
88negative regulation of sterol transport (GO:0032372)3.69545494
89negative regulation of cholesterol transport (GO:0032375)3.69545494
90regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.68063854
91regulation of mitotic spindle checkpoint (GO:1903504)3.68063854
92mitotic spindle checkpoint (GO:0071174)3.67597835
93aspartate family amino acid catabolic process (GO:0009068)3.66393793
94bile acid and bile salt transport (GO:0015721)3.62285307
95fatty acid oxidation (GO:0019395)3.61977024
96spindle checkpoint (GO:0031577)3.61961329
97positive regulation of fatty acid beta-oxidation (GO:0032000)3.61658787
98regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.59815124
99regulation of mitotic metaphase/anaphase transition (GO:0030071)3.59815124
100nuclear pore complex assembly (GO:0051292)3.59524486
101lipid oxidation (GO:0034440)3.58819156
102phospholipid homeostasis (GO:0055091)3.54740101
103negative regulation of DNA-dependent DNA replication (GO:2000104)3.53738956
104positive regulation of lipid catabolic process (GO:0050996)3.53138637
105fatty acid transmembrane transport (GO:1902001)3.51422007
106low-density lipoprotein particle remodeling (GO:0034374)3.51183847
107DNA replication checkpoint (GO:0000076)3.50396129
108cholesterol efflux (GO:0033344)3.49664675
109regulation of sister chromatid segregation (GO:0033045)3.49528549
110regulation of mitotic sister chromatid separation (GO:0010965)3.49528549
111regulation of mitotic sister chromatid segregation (GO:0033047)3.49528549
112DNA replication-independent nucleosome organization (GO:0034724)3.48301456
113DNA replication-independent nucleosome assembly (GO:0006336)3.48301456
114fibrinolysis (GO:0042730)3.46988357
115fatty acid catabolic process (GO:0009062)3.46648388
116mitotic spindle assembly checkpoint (GO:0007094)3.46603593
117monocarboxylic acid catabolic process (GO:0072329)3.46537208
118organic acid catabolic process (GO:0016054)3.45421863
119carboxylic acid catabolic process (GO:0046395)3.45421863
120benzene-containing compound metabolic process (GO:0042537)3.44214698
121serine family amino acid biosynthetic process (GO:0009070)3.42881928
122plasma lipoprotein particle assembly (GO:0034377)3.41759699
123metaphase plate congression (GO:0051310)3.41078805
124indolalkylamine metabolic process (GO:0006586)3.38121225
125valine metabolic process (GO:0006573)3.37494069
126carnitine metabolic process (GO:0009437)3.37442268
127spindle assembly checkpoint (GO:0071173)3.36590361
128amine catabolic process (GO:0009310)3.36172237
129cellular biogenic amine catabolic process (GO:0042402)3.36172237
130serine family amino acid metabolic process (GO:0009069)3.34353376
131drug catabolic process (GO:0042737)3.33325359
132nuclear pore organization (GO:0006999)3.32676970
133positive regulation of fatty acid oxidation (GO:0046321)3.32312578
134transcytosis (GO:0045056)3.31588406
135arginine metabolic process (GO:0006525)3.31413662
136* glucuronate metabolic process (GO:0019585)3.30810274
137* uronic acid metabolic process (GO:0006063)3.30810274
138telomere maintenance via telomerase (GO:0007004)3.29416994
139negative regulation of mitosis (GO:0045839)3.28577017
140glycine metabolic process (GO:0006544)3.28496777
141regulation of cholesterol homeostasis (GO:2000188)3.28126182
142very-low-density lipoprotein particle assembly (GO:0034379)3.27257503
143aldehyde catabolic process (GO:0046185)3.26778582
144negative regulation of lipase activity (GO:0060192)3.26177272
145cellular protein complex localization (GO:0034629)3.25605753
146tricarboxylic acid cycle (GO:0006099)3.25445178
147opsonization (GO:0008228)3.24565575
148regulation of chromosome segregation (GO:0051983)3.24545748
149mitotic G2/M transition checkpoint (GO:0044818)3.24336965
150cholesterol homeostasis (GO:0042632)3.23725395
151regulation of cholesterol metabolic process (GO:0090181)3.23625961
152nucleobase biosynthetic process (GO:0046112)3.22574018
153carnitine shuttle (GO:0006853)3.21393782
154protein-lipid complex assembly (GO:0065005)3.20987273
155negative regulation of telomerase activity (GO:0051974)3.17821253
156regulation of cell fate specification (GO:0042659)3.17556215
157negative regulation of DNA recombination (GO:0045910)3.17253558
158NADH metabolic process (GO:0006734)3.11868361
159somatic diversification of immune receptors via somatic mutation (GO:0002566)3.11490913
160somatic hypermutation of immunoglobulin genes (GO:0016446)3.11490913
161L-alpha-amino acid transmembrane transport (GO:1902475)3.11256723
162DNA double-strand break processing (GO:0000729)3.09322814
163regulation of histone H3-K9 methylation (GO:0051570)3.08822084
164female gonad development (GO:0008585)3.07959732
165DNA strand elongation involved in DNA replication (GO:0006271)3.05125609
166proteasome assembly (GO:0043248)3.04846386
167heterochromatin organization (GO:0070828)3.04620576
168gap junction assembly (GO:0016264)3.02669710
169DNA replication-dependent nucleosome organization (GO:0034723)3.00220931
170DNA replication-dependent nucleosome assembly (GO:0006335)3.00220931
171RNA-dependent DNA replication (GO:0006278)2.99659118
172response to X-ray (GO:0010165)2.94284901
173negative regulation of nuclear division (GO:0051784)2.93246059
174ventricular cardiac muscle cell development (GO:0055015)2.89632806
175protein localization to chromosome, centromeric region (GO:0071459)2.88567883
176negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.86839069
177cell fate commitment involved in formation of primary germ layer (GO:0060795)2.84650158
178DNA strand elongation (GO:0022616)2.83419092
179negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81935194
180regulation of SMAD protein import into nucleus (GO:0060390)2.79502775
181mitotic G2 DNA damage checkpoint (GO:0007095)2.78720380
182regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.76565118
183regulation of telomere maintenance via telomerase (GO:0032210)2.74319931
184double-strand break repair via nonhomologous end joining (GO:0006303)2.73444214
185non-recombinational repair (GO:0000726)2.73444214
186bundle of His cell to Purkinje myocyte communication (GO:0086069)2.71820841
187regulation of cofactor metabolic process (GO:0051193)2.69523096
188regulation of coenzyme metabolic process (GO:0051196)2.69523096
189regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.69186942
190lung-associated mesenchyme development (GO:0060484)2.67395741
191negative regulation of fibroblast apoptotic process (GO:2000270)2.66368680
192positive regulation of chromosome segregation (GO:0051984)2.66132233
193establishment of chromosome localization (GO:0051303)2.65526513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.78028362
2E2F7_22180533_ChIP-Seq_HELA_Human7.07574048
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.85080336
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.89976923
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.50083424
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.44409106
7EGR1_23403033_ChIP-Seq_LIVER_Mouse5.18000035
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.30912587
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.57614919
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.53302714
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45294627
12SALL1_21062744_ChIP-ChIP_HESCs_Human3.00037726
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.97806103
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.97806103
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.97806103
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92409834
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.91431130
18AR_21909140_ChIP-Seq_LNCAP_Human2.88609167
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.77097049
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.73703602
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62424673
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.61439144
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.56648922
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.56493039
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43366488
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.43102732
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33573024
28NANOG_16153702_ChIP-ChIP_HESCs_Human2.32687325
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32262314
30CLOCK_20551151_ChIP-Seq_293T_Human2.31799114
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30761189
32POU5F1_16153702_ChIP-ChIP_HESCs_Human2.27552920
33TCF3_18692474_ChIP-Seq_MEFs_Mouse2.26656037
34MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15936236
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95743891
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89647014
37SOX2_16153702_ChIP-ChIP_HESCs_Human1.84278055
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82947910
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.82437013
40* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81656057
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.80340871
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.79984517
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76285146
44ELK1_19687146_ChIP-ChIP_HELA_Human1.72522292
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.71768422
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71110487
47TCF3_18692474_ChIP-Seq_MESCs_Mouse1.69034270
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.68434944
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.67873034
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62415940
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59906644
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59195864
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56945198
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.56631520
55* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54264262
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51302298
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49050636
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45581460
59GATA1_22025678_ChIP-Seq_K562_Human1.45041842
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44205819
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42608084
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40000986
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40000986
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39122142
65* E2F1_21310950_ChIP-Seq_MCF-7_Human1.39039332
66NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.38364882
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.37599732
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.37422310
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36668164
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35468257
71FUS_26573619_Chip-Seq_HEK293_Human1.32802402
72HTT_18923047_ChIP-ChIP_STHdh_Human1.31615376
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30047545
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29870460
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29398932
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29019480
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27557595
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25936750
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25805986
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24974563
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22771728
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.22271260
83NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22242983
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.21411828
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20832783
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20340587
87P300_19829295_ChIP-Seq_ESCs_Human1.19929171
88* HNF4A_19822575_ChIP-Seq_HepG2_Human1.17632356
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17213683
90EWS_26573619_Chip-Seq_HEK293_Human1.16045138
91SOX17_20123909_ChIP-Seq_XEN_Mouse1.14185375
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14180113
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14073402
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11122555
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.10145560
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09596191
97SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08621864
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08312510
99TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07907392
100NANOG_16518401_ChIP-PET_MESCs_Mouse1.07046008
101TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06506660
102* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05645418
103SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05596107
104* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05398048
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04864139
106TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04515520
107SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04080317
108PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02905275
109ESR1_21235772_ChIP-Seq_MCF-7_Human1.02451557
110GATA1_26923725_Chip-Seq_HPCs_Mouse1.01973002
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01934336
112POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01265956
113NFE2_27457419_Chip-Seq_LIVER_Mouse0.97792314
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97551525
115THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97411244
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97259213
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97195576
118* TBX20_22080862_ChIP-Seq_HEART_Mouse0.96973787
119* TBX20_22328084_ChIP-Seq_HEART_Mouse0.96973787
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96494124
121EP300_21415370_ChIP-Seq_HL-1_Mouse0.96059480
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95332917
123GATA4_25053715_ChIP-Seq_YYC3_Human0.94030331
124NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93987839
125NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93345413
126FOXP3_21729870_ChIP-Seq_TREG_Human0.92815808
127ZNF263_19887448_ChIP-Seq_K562_Human0.92540449
128NANOG_21062744_ChIP-ChIP_HESCs_Human0.92439876
129AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91530773
130* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90614762
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90603758
132ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90061594
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.88905525
134HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88267430
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87431138
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87109569
137CJUN_26792858_Chip-Seq_BT549_Human0.86985959
138SOX2_20726797_ChIP-Seq_SW620_Human0.85244304
139PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84593575
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84463291
141CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78669423
142EGR1_19032775_ChIP-ChIP_M12_Human0.77634070
143* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76645343
144IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.76186544
145RXRA_24833708_ChIP-Seq_LIVER_Mouse0.74627759
146SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74585551
147ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73297723
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.72624466
149AR_21572438_ChIP-Seq_LNCaP_Human0.70928318
150* BCAT_22108803_ChIP-Seq_LS180_Human0.70606091
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67132586
152FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66974397
153PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.64865497
154NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64802149
155TP63_17297297_ChIP-ChIP_HaCaT_Human0.64632395
156GATA3_24758297_ChIP-Seq_MCF-7_Human0.64053418
157CBP_21632823_ChIP-Seq_H3396_Human0.63812898
158* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.62881616
159ZNF217_24962896_ChIP-Seq_MCF-7_Human0.61174712
160TP63_23658742_ChIP-Seq_EP156T_Human0.60940102
161* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60395067
162HIF1A_21447827_ChIP-Seq_MCF-7_Human0.59319702
163EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.59218875
164GATA2_21666600_ChIP-Seq_HMVEC_Human0.58860861
165FOXA1_25552417_ChIP-Seq_VCAP_Human0.58441749
166CDX2_20551321_ChIP-Seq_CACO-2_Human0.57443618
167P63_26484246_Chip-Seq_KERATINOCYTES_Human0.56589550
168CDX2_22108803_ChIP-Seq_LS180_Human0.56176870
169CEBPB_22108803_ChIP-Seq_LS180_Human0.56104904
170FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.56057845
171GATA2_19941826_ChIP-Seq_K562_Human0.55386819
172NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.55253135
173* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.54108337
174RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53933694
175RXR_22108803_ChIP-Seq_LS180_Human0.53785614
176ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52277078
177NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.51578977
178JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.51069220
179* AR_20517297_ChIP-Seq_VCAP_Human0.50565753
180* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.50262975
181ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.49955079
182ERG_21242973_ChIP-ChIP_JURKAT_Human0.49417927
183CSB_26484114_Chip-Seq_FIBROBLAST_Human0.49386832
184TP53_18474530_ChIP-ChIP_U2OS_Human0.48745900
185RACK7_27058665_Chip-Seq_MCF-7_Human0.48199255
186SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48180290

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.08076121
2MP0003941_abnormal_skin_development6.54370831
3MP0005360_urolithiasis6.44238800
4MP0005085_abnormal_gallbladder_physiolo5.36347972
5MP0005365_abnormal_bile_salt5.08321982
6MP0008875_abnormal_xenobiotic_pharmacok4.29768563
7MP0003806_abnormal_nucleotide_metabolis4.00684652
8MP0004957_abnormal_blastocyst_morpholog3.40960403
9MP0003252_abnormal_bile_duct3.30416744
10MP0003693_abnormal_embryo_hatching3.20951492
11MP0010329_abnormal_lipoprotein_level3.15664618
12MP0009840_abnormal_foam_cell2.91860570
13MP0009672_abnormal_birth_weight2.83383761
14MP0010094_abnormal_chromosome_stability2.68774100
15MP0005332_abnormal_amino_acid2.67093281
16MP0003111_abnormal_nucleus_morphology2.67068608
17MP0003718_maternal_effect2.65833800
18MP0010352_gastrointestinal_tract_polyps2.64147033
19MP0005083_abnormal_biliary_tract2.53523761
20MP0003195_calcinosis2.51092973
21MP0008057_abnormal_DNA_replication2.40912994
22MP0003890_abnormal_embryonic-extraembry2.36664232
23MP0008877_abnormal_DNA_methylation2.29161211
24MP0003567_abnormal_fetal_cardiomyocyte2.27363085
25MP0008058_abnormal_DNA_repair2.26592271
26MP0008932_abnormal_embryonic_tissue2.24905779
27MP0001666_abnormal_nutrient_absorption2.20251029
28MP0003191_abnormal_cellular_cholesterol2.02253957
29MP0002118_abnormal_lipid_homeostasis1.97930341
30MP0008007_abnormal_cellular_replicative1.94727003
31MP0001730_embryonic_growth_arrest1.93830860
32MP0003077_abnormal_cell_cycle1.93395670
33MP0003705_abnormal_hypodermis_morpholog1.90802647
34MP0004130_abnormal_muscle_cell1.86864684
35MP0000609_abnormal_liver_physiology1.84939211
36MP0004019_abnormal_vitamin_homeostasis1.73957508
37MP0002837_dystrophic_cardiac_calcinosis1.72771827
38MP0005319_abnormal_enzyme/_coenzyme1.70167343
39MP0003646_muscle_fatigue1.69137329
40MP0001188_hyperpigmentation1.67440544
41MP0004272_abnormal_basement_membrane1.62861506
42MP0001293_anophthalmia1.59963617
43MP0000579_abnormal_nail_morphology1.59136075
44MP0002138_abnormal_hepatobiliary_system1.59135595
45MP0005584_abnormal_enzyme/coenzyme_acti1.57825040
46MP0003868_abnormal_feces_composition1.46116800
47MP0002796_impaired_skin_barrier1.41182967
48MP0003566_abnormal_cell_adhesion1.39253461
49MP0009703_decreased_birth_body1.38536591
50MP0005408_hypopigmentation1.37659105
51MP0008438_abnormal_cutaneous_collagen1.36902145
52MP0009697_abnormal_copulation1.35322586
53MP0002254_reproductive_system_inflammat1.32360033
54MP0001177_atelectasis1.32335263
55MP0000350_abnormal_cell_proliferation1.31086830
56MP0003186_abnormal_redox_activity1.30741165
57MP0003136_yellow_coat_color1.29813159
58MP0001299_abnormal_eye_distance/1.26099896
59MP0000749_muscle_degeneration1.26069533
60MP0000372_irregular_coat_pigmentation1.25110712
61MP0005451_abnormal_body_composition1.24234308
62MP0000751_myopathy1.23875656
63MP0003656_abnormal_erythrocyte_physiolo1.22822507
64MP0001672_abnormal_embryogenesis/_devel1.22304145
65MP0005380_embryogenesis_phenotype1.22304145
66MP0009643_abnormal_urine_homeostasis1.18537059
67MP0003011_delayed_dark_adaptation1.18062320
68MP0001764_abnormal_homeostasis1.17996996
69MP0002085_abnormal_embryonic_tissue1.17665580
70MP0004036_abnormal_muscle_relaxation1.17422833
71MP0003123_paternal_imprinting1.15525829
72MP0002697_abnormal_eye_size1.14897489
73MP0010030_abnormal_orbit_morphology1.14824409
74MP0002084_abnormal_developmental_patter1.14445350
75MP0000604_amyloidosis1.14430776
76MP0006036_abnormal_mitochondrial_physio1.13411646
77MP0003937_abnormal_limbs/digits/tail_de1.13165849
78MP0001697_abnormal_embryo_size1.12602472
79MP0009384_cardiac_valve_regurgitation1.12458808
80MP0001881_abnormal_mammary_gland1.11619895
81MP0002971_abnormal_brown_adipose1.11573427
82MP0010630_abnormal_cardiac_muscle1.10701081
83MP0005670_abnormal_white_adipose1.10535426
84MP0003690_abnormal_glial_cell1.05855060
85MP0010368_abnormal_lymphatic_system1.05358038
86MP0005666_abnormal_adipose_tissue1.05102632
87MP0003984_embryonic_growth_retardation1.03514955
88MP0002088_abnormal_embryonic_growth/wei1.03382680
89MP0002080_prenatal_lethality1.02320010
90MP0005395_other_phenotype1.02213703
91MP0000762_abnormal_tongue_morphology1.01811453
92MP0003119_abnormal_digestive_system1.00810689
93MP0000747_muscle_weakness0.99631306
94MP0006292_abnormal_olfactory_placode0.99416137
95MP0005330_cardiomyopathy0.97247547
96MP0004233_abnormal_muscle_weight0.95968486
97MP0002269_muscular_atrophy0.94256106
98MP0009764_decreased_sensitivity_to0.94074786
99MP0000598_abnormal_liver_morphology0.91993994
100MP0004087_abnormal_muscle_fiber0.91274885
101MP0003950_abnormal_plasma_membrane0.91094737
102MP0001849_ear_inflammation0.90886778
103MP0004197_abnormal_fetal_growth/weight/0.90506037
104MP0002086_abnormal_extraembryonic_tissu0.88552618
105MP0005275_abnormal_skin_tensile0.86947376
106MP0005620_abnormal_muscle_contractility0.86661839
107MP0002233_abnormal_nose_morphology0.85352594
108MP0003329_amyloid_beta_deposits0.83160269
109MP0005058_abnormal_lysosome_morphology0.80650956
110MP0004185_abnormal_adipocyte_glucose0.80197057
111MP0005636_abnormal_mineral_homeostasis0.79915266
112MP0003137_abnormal_impulse_conducting0.79619905
113MP0005647_abnormal_sex_gland0.79105372
114MP0010307_abnormal_tumor_latency0.78087924
115MP0005334_abnormal_fat_pad0.77382898
116MP0004145_abnormal_muscle_electrophysio0.76676771
117MP0002078_abnormal_glucose_homeostasis0.76036170
118MP0009763_increased_sensitivity_to0.74779279
119MP0005376_homeostasis/metabolism_phenot0.74276179
120MP0004084_abnormal_cardiac_muscle0.74241649
121MP0001485_abnormal_pinna_reflex0.74093205
122MP0009642_abnormal_blood_homeostasis0.70913250
123MP0001915_intracranial_hemorrhage0.70857605
124MP0003221_abnormal_cardiomyocyte_apopto0.69322307
125MP0003121_genomic_imprinting0.67971207
126MP0001286_abnormal_eye_development0.67654377
127MP0008469_abnormal_protein_level0.65622250
128MP0002111_abnormal_tail_morphology0.65568153
129MP0005535_abnormal_body_temperature0.65329259
130MP0001661_extended_life_span0.65159203
131MP0005266_abnormal_metabolism0.64494161
132MP0002972_abnormal_cardiac_muscle0.64153442
133MP0003279_aneurysm0.63626206
134MP0005248_abnormal_Harderian_gland0.62069410
135MP0002106_abnormal_muscle_physiology0.61987763
136MP0005166_decreased_susceptibility_to0.60315131
137MP0001756_abnormal_urination0.60160673
138MP0000759_abnormal_skeletal_muscle0.59425686
139MP0003075_altered_response_to0.59360156
140MP0001544_abnormal_cardiovascular_syste0.58739475
141MP0005385_cardiovascular_system_phenoty0.58739475
142MP0005503_abnormal_tendon_morphology0.57653158
143MP0005084_abnormal_gallbladder_morpholo0.56631344
144MP0000230_abnormal_systemic_arterial0.56270728
145MP0005171_absent_coat_pigmentation0.55616245
146MP0002332_abnormal_exercise_endurance0.55133982
147MP0006035_abnormal_mitochondrial_morpho0.55059805
148MP0006138_congestive_heart_failure0.53260620
149MP0002295_abnormal_pulmonary_circulatio0.53163113
150MP0005369_muscle_phenotype0.52881472
151MP0004215_abnormal_myocardial_fiber0.52567737
152MP0005375_adipose_tissue_phenotype0.52141987
153MP0002108_abnormal_muscle_morphology0.51580550
154MP0002090_abnormal_vision0.48516120
155MP0008775_abnormal_heart_ventricle0.48411844
156MP0000343_altered_response_to0.48205373
157MP0005164_abnormal_response_to0.48178564
158MP0004043_abnormal_pH_regulation0.48169764
159MP0000750_abnormal_muscle_regeneration0.47863878
160MP0004381_abnormal_hair_follicle0.46704152

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.98985712
2Intrahepatic cholestasis (HP:0001406)5.85299865
3Xanthomatosis (HP:0000991)5.54102685
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.51153401
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.99536440
6Hypobetalipoproteinemia (HP:0003563)4.83967848
7Prolonged partial thromboplastin time (HP:0003645)4.83826699
8Hyperlipoproteinemia (HP:0010980)4.66086589
9Hypoalphalipoproteinemia (HP:0003233)4.36712159
10Hypolipoproteinemia (HP:0010981)4.33183302
11Hyperammonemia (HP:0001987)4.23514878
12Abnormality of the labia minora (HP:0012880)4.23468551
13Complement deficiency (HP:0004431)4.15474546
14Ketosis (HP:0001946)4.04279473
15Hypoglycemic coma (HP:0001325)3.99256976
16Colon cancer (HP:0003003)3.96562032
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.95632217
18Hyperglycinemia (HP:0002154)3.85756522
19Hyperglycinuria (HP:0003108)3.77671574
20Abnormality of serine family amino acid metabolism (HP:0010894)3.73112082
21Abnormality of glycine metabolism (HP:0010895)3.73112082
22Epidermoid cyst (HP:0200040)3.70388436
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.69051395
24Multiple enchondromatosis (HP:0005701)3.48744479
25Abnormality of the common coagulation pathway (HP:0010990)3.46565308
26Joint hemorrhage (HP:0005261)3.41615053
27Abnormality of fatty-acid metabolism (HP:0004359)3.41457135
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.38616814
29Ketoacidosis (HP:0001993)3.35269305
30Abnormality of methionine metabolism (HP:0010901)3.31285804
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.29846474
32Nephroblastoma (Wilms tumor) (HP:0002667)3.29535106
33Fat malabsorption (HP:0002630)3.26119415
34Myoglobinuria (HP:0002913)3.20713597
35Embryonal renal neoplasm (HP:0011794)3.15202752
36Exercise-induced muscle cramps (HP:0003710)3.11837254
37Exercise-induced myalgia (HP:0003738)3.11391443
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.07526119
39Abnormality of the intrinsic pathway (HP:0010989)3.03364818
40Abnormality of complement system (HP:0005339)2.98837139
41Septo-optic dysplasia (HP:0100842)2.93296386
42Biliary tract neoplasm (HP:0100574)2.89931005
43Ependymoma (HP:0002888)2.88620062
44Hypercholesterolemia (HP:0003124)2.87972727
45Rhabdomyosarcoma (HP:0002859)2.86762077
46Choanal stenosis (HP:0000452)2.83582357
47Abnormal lung lobation (HP:0002101)2.83061753
48Pancreatic islet-cell hyperplasia (HP:0004510)2.76975695
49Dicarboxylic aciduria (HP:0003215)2.72266286
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72266286
51Skin nodule (HP:0200036)2.70659589
52Muscle fiber inclusion bodies (HP:0100299)2.69236196
53Agnosia (HP:0010524)2.67863139
54Abnormality of serum amino acid levels (HP:0003112)2.67108954
55Hepatocellular carcinoma (HP:0001402)2.66013929
56Myocardial infarction (HP:0001658)2.63426735
57Stenosis of the external auditory canal (HP:0000402)2.63397625
58Birth length less than 3rd percentile (HP:0003561)2.62337305
59Abnormality of purine metabolism (HP:0004352)2.60673657
60Hyperbilirubinemia (HP:0002904)2.59763887
61Conjugated hyperbilirubinemia (HP:0002908)2.57343802
62Metabolic acidosis (HP:0001942)2.56809701
63Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.55039832
64Rhabdomyolysis (HP:0003201)2.54268798
65Neoplasm of the colon (HP:0100273)2.51255497
66Abnormality of nucleobase metabolism (HP:0010932)2.49143695
67Rimmed vacuoles (HP:0003805)2.47963135
68Gout (HP:0001997)2.45049663
69Cerebral edema (HP:0002181)2.44208657
70Steatorrhea (HP:0002570)2.44051247
71Abnormal gallbladder morphology (HP:0012437)2.43787374
72Cholelithiasis (HP:0001081)2.42497152
73Neoplasm of the small intestine (HP:0100833)2.41655323
74Increased serum pyruvate (HP:0003542)2.40104594
75Lethargy (HP:0001254)2.39837945
76Palpitations (HP:0001962)2.38663838
77Delayed CNS myelination (HP:0002188)2.38100739
78Vascular calcification (HP:0004934)2.35852138
79Nemaline bodies (HP:0003798)2.35341629
80Maternal diabetes (HP:0009800)2.34935070
81Type 1 muscle fiber predominance (HP:0003803)2.34101433
82Symptomatic seizures (HP:0011145)2.33653800
83Reduced antithrombin III activity (HP:0001976)2.32559122
84Generalized aminoaciduria (HP:0002909)2.31400206
85Neoplasm of the adrenal gland (HP:0100631)2.29425258
86Abnormal gallbladder physiology (HP:0012438)2.27856034
87Cholecystitis (HP:0001082)2.27856034
88Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27734474
89Abnormality of pyrimidine metabolism (HP:0004353)2.26083771
90Systemic lupus erythematosus (HP:0002725)2.24723055
91Cortical dysplasia (HP:0002539)2.24602523
92Hydroxyprolinuria (HP:0003080)2.24338596
93Abnormality of proline metabolism (HP:0010907)2.24338596
94Cardiovascular calcification (HP:0011915)2.23435471
95Spontaneous abortion (HP:0005268)2.20602507
96Abnormality of glycolysis (HP:0004366)2.20443916
97Chromsome breakage (HP:0040012)2.18946838
98Neoplasm of the rectum (HP:0100743)2.18315580
99Megaloblastic anemia (HP:0001889)2.17668815
100Hypoglycemic seizures (HP:0002173)2.16827078
101Ovarian neoplasm (HP:0100615)2.14749951
102Abnormal cartilage morphology (HP:0002763)2.14320198
103Medulloblastoma (HP:0002885)2.13261198
104Hyporeflexia of lower limbs (HP:0002600)2.12250187
105Abnormal hair whorl (HP:0010721)2.11658312
106Uterine neoplasm (HP:0010784)2.08789562
107Muscle fiber splitting (HP:0003555)2.07341029
108Mitral stenosis (HP:0001718)2.06227376
109Asymmetric septal hypertrophy (HP:0001670)2.05788069
110Sensorimotor neuropathy (HP:0007141)2.05692689
111Selective tooth agenesis (HP:0001592)2.04948755
112Hepatoblastoma (HP:0002884)2.02551051
113Vomiting (HP:0002013)2.01703509
114Chronic bronchitis (HP:0004469)2.01551217
115Abnormality of the salivary glands (HP:0010286)2.01300306
116Malignant gastrointestinal tract tumors (HP:0006749)2.00743896
117Gastrointestinal carcinoma (HP:0002672)2.00743896
118Increased purine levels (HP:0004368)2.00070018
119Hyperuricemia (HP:0002149)2.00070018
120Absent septum pellucidum (HP:0001331)1.99357284
121Esophageal varix (HP:0002040)1.98757711
122Progressive external ophthalmoplegia (HP:0000590)1.98648153
123Malnutrition (HP:0004395)1.98524145
124Spastic diplegia (HP:0001264)1.98472901
125Gonadotropin excess (HP:0000837)1.98414004
126Meckel diverticulum (HP:0002245)1.98345404
127Abnormal tarsal ossification (HP:0008369)1.97826706
128Muscle stiffness (HP:0003552)1.97690575
129Right ventricular cardiomyopathy (HP:0011663)1.97553461
130Hyperinsulinemic hypoglycemia (HP:0000825)1.97098874
131Abnormality of the septum pellucidum (HP:0007375)1.96313109
132Back pain (HP:0003418)1.95270027
133Late onset (HP:0003584)1.94464164
134Hyperglycemia (HP:0003074)1.93823886
135Abnormality of chromosome stability (HP:0003220)1.93439019
136Clitoromegaly (HP:0000057)1.92458789
137Protuberant abdomen (HP:0001538)1.92184327
138Neonatal onset (HP:0003623)1.90989336
139Abnormality of the clitoris (HP:0000056)1.90880591
140Proximal tubulopathy (HP:0000114)1.88276754
141Amyloidosis (HP:0011034)1.87864332
142Abnormality of the Achilles tendon (HP:0005109)1.87160774
143Muscle hypertrophy of the lower extremities (HP:0008968)1.86971227
144Pterygium (HP:0001059)1.86885319
145Ventricular tachycardia (HP:0004756)1.86097848
146Enlarged kidneys (HP:0000105)1.85779609
147Methylmalonic acidemia (HP:0002912)1.84277818
148Abnormality of the gallbladder (HP:0005264)1.83309943
149Pancreatitis (HP:0001733)1.83275204
150Decreased muscle mass (HP:0003199)1.82708556
151Distal arthrogryposis (HP:0005684)1.82438541
152Abnormality of homocysteine metabolism (HP:0010919)1.81877893
153Homocystinuria (HP:0002156)1.81877893
154Irritability (HP:0000737)1.81320922
155Calf muscle hypertrophy (HP:0008981)1.80918145
156Myelomeningocele (HP:0002475)1.80487257
157Neck muscle weakness (HP:0000467)1.80206231
158Abnormality of the ileum (HP:0001549)1.76112675
159Short hallux (HP:0010109)1.75963529
160Bifid tongue (HP:0010297)1.71741346
161Duodenal stenosis (HP:0100867)1.71534007
162Small intestinal stenosis (HP:0012848)1.71534007
163Aplasia/Hypoplasia of the sternum (HP:0006714)1.69352253
164Shoulder girdle muscle weakness (HP:0003547)1.68981292
165Calcaneovalgus deformity (HP:0001848)1.68901033
166Breast carcinoma (HP:0003002)1.68559713
167EMG: myopathic abnormalities (HP:0003458)1.68448760
168Sudden death (HP:0001699)1.67660934
169Fused cervical vertebrae (HP:0002949)1.67557266
170Areflexia of lower limbs (HP:0002522)1.67417281
171Supernumerary spleens (HP:0009799)1.66935064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.98043000
2BUB14.09388903
3TTK3.88635113
4MST1R3.78244354
5OBSCN3.53475936
6TSSK63.49639422
7CDC73.40088986
8TRIB33.27884126
9SIK13.13420304
10TNIK3.04394330
11MKNK23.02367618
12TTN2.89304992
13PLK32.86310809
14PKN22.84675662
15MKNK12.80818098
16MST42.72350778
17ERN12.47597391
18EIF2AK32.40550025
19FGFR42.31993665
20PHKG22.30972411
21PHKG12.30972411
22PIK3CG2.27230718
23ZAK2.09188072
24TAF12.06603721
25INSRR2.04867139
26MET1.93130768
27VRK21.89712776
28SRPK11.85159022
29BRSK21.82933988
30PDK41.78303318
31PDK31.78303318
32TRIM281.75655111
33LATS11.72686794
34PLK41.69428382
35ERBB41.65871683
36NEK91.64928284
37PINK11.64519212
38FRK1.64098307
39NLK1.51553600
40PLK11.51522373
41ACVR1B1.51482318
42MAP2K31.47780809
43MAP2K41.45722226
44PIK3CA1.44829059
45MAP3K31.44677347
46ALK1.44445134
47STK38L1.42942658
48MAP3K71.41085340
49WNK31.40606451
50LMTK21.40417813
51NUAK11.39560115
52PTK61.34187483
53EPHB11.33203158
54PDK21.31541324
55FLT31.23147097
56VRK11.22696050
57MAPK121.19019116
58STK161.16273641
59BMPR1B1.14833658
60FGFR21.14727639
61TAOK31.14727483
62PRKAA21.12870504
63MAPK111.11530026
64EIF2AK11.05824919
65EPHA31.03902747
66MAP3K101.00836097
67CDK190.99447027
68BMX0.97703076
69EIF2AK20.97192366
70RIPK10.96458860
71DDR20.95615676
72NEK10.94385212
73STK240.92675945
74WEE10.91046713
75MAP3K90.89684249
76TGFBR20.87791758
77PAK40.84338523
78ABL20.83908625
79DYRK20.82566850
80MYLK0.82343050
81TRPM70.78529518
82OXSR10.78022933
83DYRK30.77258266
84TYK20.72425466
85CAMK2G0.70677626
86PRKAA10.70534939
87PDGFRA0.69883043
88NME10.68949196
89JAK10.68929587
90TIE10.68839676
91JAK20.68606649
92PAK30.68170316
93DMPK0.68003476
94PLK20.66149397
95ATM0.64685745
96PDPK10.63642787
97AURKB0.63443562
98FGFR30.63060278
99GSK3A0.62279335
100MAP2K10.61066694
101STK40.60220347
102SGK30.59926107
103CHEK20.59286637
104BRSK10.59160238
105TGFBR10.59086925
106TBK10.58095987
107CAMK1D0.55848206
108LRRK20.53363959
109PRKACG0.53172813
110BRAF0.52783208
111RET0.52663583
112DAPK10.52090895
113CSNK1G10.52050002
114CHEK10.51425814
115ATR0.51345811
116PBK0.51226011
117CSNK1E0.50881504
118MAP3K110.50117200
119MAPK40.49929815
120MAP2K60.49849907
121FER0.49380156
122PASK0.49084649
123MARK30.48934060
124PRKDC0.47430332
125KDR0.47418040
126STK390.47135947
127NEK20.46481790
128PTK20.46239605
129ROCK10.45602027
130BCR0.44421763
131STK30.44227921
132MAP3K120.43141732
133DAPK20.42825607
134MAPK70.42721293
135PRKD10.42475142
136PRKCQ0.42226652
137WNK40.41912702
138PRKG20.41761418
139KSR20.41697932
140PDK10.41096309
141PRKCZ0.41046568
142CSNK2A10.39108559
143CASK0.38555934
144MAP3K50.38407970
145LATS20.38192845
146SGK20.37851194
147SGK2230.37412750
148SGK4940.37412750
149IGF1R0.37019651
150EPHB20.36759646
151ERBB20.35911788
152YES10.35753180
153CDK10.35640156
154EGFR0.35288887
155CSNK2A20.34783482
156MAP3K80.34124731
157FGFR10.33918501
158CDK70.31703457
159TAOK20.31273467
160CDK60.31139993
161RPS6KA40.30852938
162CAMK2D0.30042506
163CDK20.29855345
164MAP3K10.29732919
165ERBB30.28476991
166PAK10.28296646
167PAK20.26987542
168DYRK1A0.25108981
169PRKCE0.24339253
170PRKG10.22835962
171MELK0.21938534
172SMG10.21153174

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.81679122
2Nitrogen metabolism_Homo sapiens_hsa009103.80576513
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17070212
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.01794638
5Fatty acid degradation_Homo sapiens_hsa000712.83676501
6Arginine biosynthesis_Homo sapiens_hsa002202.82402323
7Mismatch repair_Homo sapiens_hsa034302.71421511
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66185634
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61116448
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56948237
11Propanoate metabolism_Homo sapiens_hsa006402.50385657
12Tryptophan metabolism_Homo sapiens_hsa003802.42474675
13Complement and coagulation cascades_Homo sapiens_hsa046102.37988971
14Proteasome_Homo sapiens_hsa030502.32167860
15Butanoate metabolism_Homo sapiens_hsa006502.20143521
16Fatty acid metabolism_Homo sapiens_hsa012122.19602530
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17046901
18DNA replication_Homo sapiens_hsa030302.16270952
19Non-homologous end-joining_Homo sapiens_hsa034502.06409646
20PPAR signaling pathway_Homo sapiens_hsa033202.05426108
21Peroxisome_Homo sapiens_hsa041462.01290530
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00301804
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99977447
24* Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94384181
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94178100
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82603221
27Chemical carcinogenesis_Homo sapiens_hsa052041.73206145
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71972716
29Caffeine metabolism_Homo sapiens_hsa002321.67457780
30beta-Alanine metabolism_Homo sapiens_hsa004101.65558729
31Sulfur metabolism_Homo sapiens_hsa009201.64965719
32Histidine metabolism_Homo sapiens_hsa003401.60241031
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59335028
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58525802
35Pyruvate metabolism_Homo sapiens_hsa006201.58050550
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.57629984
37* Starch and sucrose metabolism_Homo sapiens_hsa005001.52510895
38Carbon metabolism_Homo sapiens_hsa012001.51683646
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51103534
40Tyrosine metabolism_Homo sapiens_hsa003501.49579827
41Fatty acid elongation_Homo sapiens_hsa000621.48013160
42Staphylococcus aureus infection_Homo sapiens_hsa051501.44490602
43Bile secretion_Homo sapiens_hsa049761.44229848
44Retinol metabolism_Homo sapiens_hsa008301.42693702
45Phenylalanine metabolism_Homo sapiens_hsa003601.40767366
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40278442
47Cell cycle_Homo sapiens_hsa041101.36663776
48RNA transport_Homo sapiens_hsa030131.35217272
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32331194
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.27869116
51Biosynthesis of amino acids_Homo sapiens_hsa012301.26589943
52Steroid biosynthesis_Homo sapiens_hsa001001.24692192
53Selenocompound metabolism_Homo sapiens_hsa004501.21625190
54RNA polymerase_Homo sapiens_hsa030201.16811835
55Spliceosome_Homo sapiens_hsa030401.14521870
56Arginine and proline metabolism_Homo sapiens_hsa003301.10211232
57Fat digestion and absorption_Homo sapiens_hsa049751.09886541
58RNA degradation_Homo sapiens_hsa030181.06617419
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05851275
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.02899602
61Base excision repair_Homo sapiens_hsa034101.01705790
62Homologous recombination_Homo sapiens_hsa034401.01536545
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00329877
64Fatty acid biosynthesis_Homo sapiens_hsa000610.99865776
65ABC transporters_Homo sapiens_hsa020100.96689629
66Tight junction_Homo sapiens_hsa045300.86737625
67Folate biosynthesis_Homo sapiens_hsa007900.85443759
68mRNA surveillance pathway_Homo sapiens_hsa030150.84660679
69Nucleotide excision repair_Homo sapiens_hsa034200.84137021
70Adherens junction_Homo sapiens_hsa045200.82091006
71Basal transcription factors_Homo sapiens_hsa030220.81957358
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77254933
73Oocyte meiosis_Homo sapiens_hsa041140.77213926
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75159931
75Glutathione metabolism_Homo sapiens_hsa004800.73861440
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72629178
77Vitamin digestion and absorption_Homo sapiens_hsa049770.69676399
78Glycerolipid metabolism_Homo sapiens_hsa005610.69639792
79Pentose phosphate pathway_Homo sapiens_hsa000300.69421537
80Purine metabolism_Homo sapiens_hsa002300.68471062
81Sulfur relay system_Homo sapiens_hsa041220.67823877
82Lysine degradation_Homo sapiens_hsa003100.67356458
83Protein export_Homo sapiens_hsa030600.64905801
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.59569819
85Thyroid cancer_Homo sapiens_hsa052160.54306982
86Vitamin B6 metabolism_Homo sapiens_hsa007500.53841555
87Insulin resistance_Homo sapiens_hsa049310.50866525
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.50638876
89Fanconi anemia pathway_Homo sapiens_hsa034600.50242789
90Fructose and mannose metabolism_Homo sapiens_hsa000510.50194111
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.49349806
92Pyrimidine metabolism_Homo sapiens_hsa002400.47279770
93* Metabolic pathways_Homo sapiens_hsa011000.45211975
94* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42167048
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41615936
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41569846
97Huntingtons disease_Homo sapiens_hsa050160.41083725
98p53 signaling pathway_Homo sapiens_hsa041150.33010848
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32921934
100Glucagon signaling pathway_Homo sapiens_hsa049220.31968570
101TGF-beta signaling pathway_Homo sapiens_hsa043500.31829363
102Wnt signaling pathway_Homo sapiens_hsa043100.30329296
103* Galactose metabolism_Homo sapiens_hsa000520.30207972
104Hippo signaling pathway_Homo sapiens_hsa043900.29408513
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27578560
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27032550
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25593848
108AMPK signaling pathway_Homo sapiens_hsa041520.23951426
109Prion diseases_Homo sapiens_hsa050200.19339142
110Insulin signaling pathway_Homo sapiens_hsa049100.17247826
111One carbon pool by folate_Homo sapiens_hsa006700.16579718
112Linoleic acid metabolism_Homo sapiens_hsa005910.15067471
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.11865168
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.10668825
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.06682558
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.05640139
117Dilated cardiomyopathy_Homo sapiens_hsa054140.02425501
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.01419660
119Cardiac muscle contraction_Homo sapiens_hsa042600.01287231
120ECM-receptor interaction_Homo sapiens_hsa045120.00080558
121Circadian rhythm_Homo sapiens_hsa04710-0.0901746
122Malaria_Homo sapiens_hsa05144-0.0875887
123Mineral absorption_Homo sapiens_hsa04978-0.0818742
124Focal adhesion_Homo sapiens_hsa04510-0.0809757
125Lysosome_Homo sapiens_hsa04142-0.0728875
126Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0656364
127Parkinsons disease_Homo sapiens_hsa05012-0.0646833
128Amoebiasis_Homo sapiens_hsa05146-0.0521172
129Alzheimers disease_Homo sapiens_hsa05010-0.0478557
130Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0403455
131Protein digestion and absorption_Homo sapiens_hsa04974-0.0178020
132Oxidative phosphorylation_Homo sapiens_hsa00190-0.0135094

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