UGT1A10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.32780510
2drug transmembrane transport (GO:0006855)8.63296303
3urate metabolic process (GO:0046415)8.17636459
4aminoglycoside antibiotic metabolic process (GO:0030647)7.96461375
5glyoxylate metabolic process (GO:0046487)7.92257563
6lysine catabolic process (GO:0006554)7.75959801
7lysine metabolic process (GO:0006553)7.75959801
8drug transport (GO:0015893)7.32477239
9* cellular glucuronidation (GO:0052695)6.85581193
10intestinal absorption (GO:0050892)6.81589017
11organic cation transport (GO:0015695)6.69646771
12cysteine metabolic process (GO:0006534)6.68932567
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.64087001
14L-phenylalanine catabolic process (GO:0006559)6.64087001
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.55761352
16L-phenylalanine metabolic process (GO:0006558)6.55761352
17* glucuronate metabolic process (GO:0019585)6.52042724
18* uronic acid metabolic process (GO:0006063)6.52042724
19aromatic amino acid family catabolic process (GO:0009074)6.40350759
20regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.34107295
21phosphate ion transport (GO:0006817)6.15686581
22tryptophan catabolic process (GO:0006569)6.15349587
23indole-containing compound catabolic process (GO:0042436)6.15349587
24indolalkylamine catabolic process (GO:0046218)6.15349587
25* flavonoid metabolic process (GO:0009812)6.14580641
26regulation of guanylate cyclase activity (GO:0031282)5.94249236
27drug catabolic process (GO:0042737)5.90364522
28exogenous drug catabolic process (GO:0042738)5.84350008
29bile acid and bile salt transport (GO:0015721)5.84251153
30response to mercury ion (GO:0046689)5.82925872
31tryptophan metabolic process (GO:0006568)5.78247309
32epoxygenase P450 pathway (GO:0019373)5.72109803
33sulfate transmembrane transport (GO:1902358)5.71846576
34serine family amino acid catabolic process (GO:0009071)5.66924358
35quaternary ammonium group transport (GO:0015697)5.61978036
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.57434959
37short-chain fatty acid metabolic process (GO:0046459)5.55106869
38citrulline biosynthetic process (GO:0019240)5.55010052
39regulation of bile acid biosynthetic process (GO:0070857)5.51846371
40desmosome organization (GO:0002934)5.47869299
41phenylpropanoid metabolic process (GO:0009698)5.41815018
42aspartate family amino acid catabolic process (GO:0009068)5.41104300
43tricarboxylic acid metabolic process (GO:0072350)5.40043629
44drinking behavior (GO:0042756)5.18989195
45cellular modified amino acid catabolic process (GO:0042219)5.15107633
46serine family amino acid metabolic process (GO:0009069)5.08367202
47phosphate ion transmembrane transport (GO:0035435)5.07038900
48bundle of His cell to Purkinje myocyte communication (GO:0086069)5.04018173
49kynurenine metabolic process (GO:0070189)4.94613055
50homocysteine metabolic process (GO:0050667)4.94111932
51amino-acid betaine metabolic process (GO:0006577)4.88243749
52fat-soluble vitamin biosynthetic process (GO:0042362)4.85101975
53lipoprotein transport (GO:0042953)4.83456272
54sulfur amino acid catabolic process (GO:0000098)4.77007386
55sulfate transport (GO:0008272)4.75673590
56branched-chain amino acid metabolic process (GO:0009081)4.75037021
57aromatic amino acid family metabolic process (GO:0009072)4.68158070
58proline metabolic process (GO:0006560)4.63445874
59vitamin D metabolic process (GO:0042359)4.61809711
60serine family amino acid biosynthetic process (GO:0009070)4.59918233
61cellular ketone body metabolic process (GO:0046950)4.59239341
62alpha-amino acid catabolic process (GO:1901606)4.58411312
63glutamate metabolic process (GO:0006536)4.56319290
642-oxoglutarate metabolic process (GO:0006103)4.54267428
65cellular amino acid catabolic process (GO:0009063)4.53659094
66nonribosomal peptide biosynthetic process (GO:0019184)4.49803659
67regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.48979822
68endocrine process (GO:0050886)4.48979822
69regulation of systemic arterial blood pressure by hormone (GO:0001990)4.48979822
70renal system process involved in regulation of blood volume (GO:0001977)4.47641691
71renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)4.39667136
72acetyl-CoA metabolic process (GO:0006084)4.35751680
73positive regulation of guanylate cyclase activity (GO:0031284)4.32391973
74valine metabolic process (GO:0006573)4.31518825
75indolalkylamine metabolic process (GO:0006586)4.30854010
76bile acid biosynthetic process (GO:0006699)4.29248500
77fatty acid beta-oxidation (GO:0006635)4.21413990
78hormone catabolic process (GO:0042447)4.19755011
79citrulline metabolic process (GO:0000052)4.17881456
80phosphate ion homeostasis (GO:0055062)4.17110329
81trivalent inorganic anion homeostasis (GO:0072506)4.17110329
82regulation of systemic arterial blood pressure (GO:0003073)4.17108612
83fatty acid oxidation (GO:0019395)4.14135307
84amino-acid betaine transport (GO:0015838)4.12338085
85carnitine transport (GO:0015879)4.12338085
86glutathione biosynthetic process (GO:0006750)4.09844659
87lipid oxidation (GO:0034440)4.06368020
88excretion (GO:0007588)4.04435389
89amine catabolic process (GO:0009310)4.04265399
90cellular biogenic amine catabolic process (GO:0042402)4.04265399
91fructose metabolic process (GO:0006000)4.02856961
92peptide hormone processing (GO:0016486)4.00853287
93branched-chain amino acid catabolic process (GO:0009083)4.00014361
94carnitine metabolic process (GO:0009437)3.98645871
95carboxylic acid catabolic process (GO:0046395)3.98092952
96organic acid catabolic process (GO:0016054)3.98092952
97dicarboxylic acid biosynthetic process (GO:0043650)3.97467575
98indole-containing compound metabolic process (GO:0042430)3.97463393
99benzene-containing compound metabolic process (GO:0042537)3.96763141
100aldehyde catabolic process (GO:0046185)3.95897600
101ketone body metabolic process (GO:1902224)3.95408072
102O-glycan processing (GO:0016266)3.90420680
103regulation of vitamin metabolic process (GO:0030656)3.89000496
104positive regulation of fatty acid beta-oxidation (GO:0032000)3.85564698
105alkaloid metabolic process (GO:0009820)3.82129216
106intestinal epithelial cell development (GO:0060576)3.78850754
107calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.77343993
108ethanol oxidation (GO:0006069)3.77121071
109renal absorption (GO:0070293)3.75922052
110digestion (GO:0007586)3.74291605
111monocarboxylic acid catabolic process (GO:0072329)3.72370704
112fatty acid catabolic process (GO:0009062)3.71789526
113drug metabolic process (GO:0017144)3.71602790
114regulation of triglyceride catabolic process (GO:0010896)3.68200568
115receptor guanylyl cyclase signaling pathway (GO:0007168)3.67125217
116modified amino acid transport (GO:0072337)3.67048061
117dicarboxylic acid metabolic process (GO:0043648)3.62546668
118sodium-independent organic anion transport (GO:0043252)3.60551707
119sulfur compound transport (GO:0072348)3.57193509
1203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.56354901
121purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.56354901
122regulation of cholesterol homeostasis (GO:2000188)3.54887180
123alpha-linolenic acid metabolic process (GO:0036109)3.53950692
124polyketide metabolic process (GO:0030638)3.53654494
125doxorubicin metabolic process (GO:0044598)3.53654494
126daunorubicin metabolic process (GO:0044597)3.53654494
127glutathione metabolic process (GO:0006749)3.53089217
128response to growth hormone (GO:0060416)3.51357482
129tyrosine metabolic process (GO:0006570)3.50760258
130urea cycle (GO:0000050)3.50597627
131urea metabolic process (GO:0019627)3.50597627
132glutamine family amino acid catabolic process (GO:0009065)3.49790792
133toxin transport (GO:1901998)3.47012641
134small molecule catabolic process (GO:0044282)3.43460405
135maintenance of gastrointestinal epithelium (GO:0030277)3.43312243
136glycine metabolic process (GO:0006544)3.42669354
137metanephric nephron tubule development (GO:0072234)3.41863330
138metanephric tubule development (GO:0072170)3.41863330
139cyclooxygenase pathway (GO:0019371)3.40798394
140vitamin transmembrane transport (GO:0035461)3.40416630
141positive regulation of lipid catabolic process (GO:0050996)3.39587712
142positive regulation of pseudopodium assembly (GO:0031274)3.39229209
143coenzyme catabolic process (GO:0009109)3.38837307
144bile acid metabolic process (GO:0008206)3.36750968
145regulation of cGMP biosynthetic process (GO:0030826)3.36370554
146positive regulation of fatty acid oxidation (GO:0046321)3.34658629
147nitrogen cycle metabolic process (GO:0071941)3.33966690
148transcytosis (GO:0045056)3.32249548
149response to phenylpropanoid (GO:0080184)3.31844583
150vitamin transport (GO:0051180)3.31376232
151phenol-containing compound catabolic process (GO:0019336)3.29746840
152NADH metabolic process (GO:0006734)3.26716461
153auditory receptor cell differentiation (GO:0042491)3.24468181
154glycoside metabolic process (GO:0016137)3.23721870
155sodium ion homeostasis (GO:0055078)3.23682949
156peptide biosynthetic process (GO:0043043)3.23234809
157negative regulation of steroid metabolic process (GO:0045939)3.19250056
158digestive system process (GO:0022600)3.17276690
159thrombin receptor signaling pathway (GO:0070493)3.16426887
160primary alcohol catabolic process (GO:0034310)3.15620108
161positive regulation of respiratory burst (GO:0060267)3.15553212
162glutamine family amino acid biosynthetic process (GO:0009084)3.15201168
163positive regulation of Cdc42 GTPase activity (GO:0043089)3.14662473
164arginine metabolic process (GO:0006525)3.13337811
165regulation of cellular extravasation (GO:0002691)3.09379553
166diacylglycerol metabolic process (GO:0046339)3.07168366
167regulation of viral release from host cell (GO:1902186)3.02589349
168glucose 6-phosphate metabolic process (GO:0051156)3.02026611
169multicellular organismal water homeostasis (GO:0050891)2.98873969
170regulation of pseudopodium assembly (GO:0031272)2.98339822
171glycerol metabolic process (GO:0006071)2.96620249
172sphingomyelin metabolic process (GO:0006684)2.95667933
173glycosphingolipid catabolic process (GO:0046479)2.94194020
174glycolipid catabolic process (GO:0019377)2.92626727
175GDP-mannose metabolic process (GO:0019673)2.91771449
176regulation of cholesterol metabolic process (GO:0090181)2.91564338
177regulation of protein glycosylation (GO:0060049)2.89048308
178ethanol metabolic process (GO:0006067)2.84375976
179nucleoside diphosphate biosynthetic process (GO:0009133)2.82903746
180glucocorticoid biosynthetic process (GO:0006704)2.82361290
181retinoic acid metabolic process (GO:0042573)2.80823138

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.82662696
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.30661784
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.27918281
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.44556772
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.95103975
6TP63_17297297_ChIP-ChIP_HaCaT_Human4.69110919
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.43328446
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.66219664
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.29071907
10* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.95267931
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.82844033
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.74420045
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.69087080
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57916489
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.41123963
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39220534
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.19177442
18KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.17574294
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.07550138
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05740559
21CLOCK_20551151_ChIP-Seq_293T_Human1.97305060
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.96236738
23KLF5_25053715_ChIP-Seq_YYC3_Human1.94655737
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.81784501
25ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.78903244
26P63_26484246_Chip-Seq_KERATINOCYTES_Human1.77361328
27RUNX1_27514584_Chip-Seq_MCF-7_Human1.76394637
28PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.72095532
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71895633
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71845333
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.67437026
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.66455023
33HNF4A_19822575_ChIP-Seq_HepG2_Human1.65889030
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62752382
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61481022
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.58708803
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.45254783
38FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.43091419
39GATA3_24758297_ChIP-Seq_MCF-7_Human1.38642636
40PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38359385
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38110508
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37513595
43LXR_22292898_ChIP-Seq_THP-1_Human1.36800398
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35640237
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.35233850
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30676454
47FOXA1_25552417_ChIP-Seq_VCAP_Human1.26856549
48AR_21909140_ChIP-Seq_LNCAP_Human1.23694660
49GATA4_25053715_ChIP-Seq_YYC3_Human1.22955372
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22100611
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20329234
52* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17868686
53* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17868686
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17790622
55ATF3_27146783_Chip-Seq_COLON_Human1.11183340
56* TP63_22573176_ChIP-Seq_HFKS_Human1.09598345
57JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07314818
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06363607
59* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05998752
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05056841
61RACK7_27058665_Chip-Seq_MCF-7_Human1.01790875
62SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00365382
63FOXO3_23340844_ChIP-Seq_DLD1_Human0.97573284
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96852515
65IRF8_22096565_ChIP-ChIP_GC-B_Human0.95902739
66SA1_27219007_Chip-Seq_Bcells_Human0.95479297
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94963516
68EGR1_19032775_ChIP-ChIP_M12_Human0.94718238
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94532634
70STAT1_20625510_ChIP-Seq_HELA_Human0.93977630
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92847454
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92711875
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92666472
74CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91317849
75TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90259278
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87481450
77BCOR_27268052_Chip-Seq_Bcells_Human0.87036648
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86810177
79GATA6_25053715_ChIP-Seq_YYC3_Human0.85816453
80BCL6_27268052_Chip-Seq_Bcells_Human0.85178517
81BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84678467
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84198071
83RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84107631
84SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83463237
85TBX20_22080862_ChIP-Seq_HEART_Mouse0.82898956
86TBX20_22328084_ChIP-Seq_HEART_Mouse0.82898956
87RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82571038
88TP63_23658742_ChIP-Seq_EP156T_Human0.81818207
89ERG_21242973_ChIP-ChIP_JURKAT_Human0.81659922
90NANOG_20526341_ChIP-Seq_ESCs_Human0.81526531
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79906526
92ELF5_23300383_ChIP-Seq_T47D_Human0.78148292
93HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77357597
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75330537
95MYC_19915707_ChIP-ChIP_AK7_Human0.74954304
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.74847262
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.74600149
98PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72390356
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.71871290
100P53_21459846_ChIP-Seq_SAOS-2_Human0.71864407
101E2F1_20622854_ChIP-Seq_HELA_Human0.71427332
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.71074606
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.70472031
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68634819
105* SOX2_20726797_ChIP-Seq_SW620_Human0.68150181
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.67360809
107* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.66766057
108TAF2_19829295_ChIP-Seq_ESCs_Human0.66261674
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.65887525
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65327571
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65107512
112NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65107512
113EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.64845026
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63991519
115AR_20517297_ChIP-Seq_VCAP_Human0.63451454
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.63388530
117P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.62627492
118* CEBPB_22108803_ChIP-Seq_LS180_Human0.62306674
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61778760
120CSB_26484114_Chip-Seq_FIBROBLAST_Human0.61623672
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.61167046
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.61165802
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59900632
124GATA2_19941826_ChIP-Seq_K562_Human0.59093786
125* RAC3_21632823_ChIP-Seq_H3396_Human0.58513332
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.58021647
127CREB1_26743006_Chip-Seq_LNCaP_Human0.57155571
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.56837816
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56739425
130SMC4_20622854_ChIP-Seq_HELA_Human0.56696429
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.56647379
132CTCF_27219007_Chip-Seq_Bcells_Human0.56644238
133RXR_22108803_ChIP-Seq_LS180_Human0.55807107
134CDX2_22108803_ChIP-Seq_LS180_Human0.55633053
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.55581385
136CBP_21632823_ChIP-Seq_H3396_Human0.55476584
137CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.54226685
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.54166675
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.53531705
140ZNF263_19887448_ChIP-Seq_K562_Human0.53473404
141SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53125899
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.52514461
143* GATA1_19941827_ChIP-Seq_MEL_Mouse0.51808342
144P68_20966046_ChIP-Seq_HELA_Human0.51581916

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.97566622
2MP0002139_abnormal_hepatobiliary_system6.97370694
3MP0005332_abnormal_amino_acid4.64108027
4MP0004019_abnormal_vitamin_homeostasis4.39445192
5MP0004043_abnormal_pH_regulation4.28903116
6MP0005085_abnormal_gallbladder_physiolo4.09033633
7MP0008875_abnormal_xenobiotic_pharmacok4.04977152
8MP0005365_abnormal_bile_salt4.02162887
9MP0003195_calcinosis3.61253519
10MP0002138_abnormal_hepatobiliary_system3.27130230
11MP0009643_abnormal_urine_homeostasis3.24013477
12MP0003252_abnormal_bile_duct3.07453876
13MP0003183_abnormal_peptide_metabolism3.00390309
14MP0003806_abnormal_nucleotide_metabolis2.95400840
15MP0000566_synostosis2.94114140
16MP0001664_abnormal_digestion2.80919341
17MP0001765_abnormal_ion_homeostasis2.68839956
18MP0005636_abnormal_mineral_homeostasis2.60443056
19MP0009379_abnormal_foot_pigmentation2.59560682
20MP0003866_abnormal_defecation2.40770264
21MP0002136_abnormal_kidney_physiology2.18022808
22MP0001756_abnormal_urination2.16898354
23MP0010155_abnormal_intestine_physiology2.15050828
24MP0001873_stomach_inflammation2.02914953
25MP0010352_gastrointestinal_tract_polyps2.00747215
26MP0000490_abnormal_crypts_of1.89349847
27MP0005584_abnormal_enzyme/coenzyme_acti1.85603421
28MP0010329_abnormal_lipoprotein_level1.85527337
29MP0005058_abnormal_lysosome_morphology1.79410502
30MP0000477_abnormal_intestine_morphology1.79270938
31MP0003186_abnormal_redox_activity1.75626378
32MP0005319_abnormal_enzyme/_coenzyme1.74659452
33MP0001666_abnormal_nutrient_absorption1.72723993
34MP0005377_hearing/vestibular/ear_phenot1.61244521
35MP0003878_abnormal_ear_physiology1.61244521
36MP0001958_emphysema1.58808010
37MP0003191_abnormal_cellular_cholesterol1.46601741
38MP0002118_abnormal_lipid_homeostasis1.45491407
39MP0005083_abnormal_biliary_tract1.42751333
40MP0000678_abnormal_parathyroid_gland1.36142351
41MP0000537_abnormal_urethra_morphology1.35428178
42MP0005381_digestive/alimentary_phenotyp1.33115497
43MP0000609_abnormal_liver_physiology1.31544086
44MP0005084_abnormal_gallbladder_morpholo1.29065054
45MP0000538_abnormal_urinary_bladder1.26088196
46MP0001764_abnormal_homeostasis1.25832932
47MP0009840_abnormal_foam_cell1.25289533
48MP0010678_abnormal_skin_adnexa1.24066447
49MP0006036_abnormal_mitochondrial_physio1.22343067
50MP0005451_abnormal_body_composition1.22320459
51MP0000462_abnormal_digestive_system1.16817413
52MP0005409_darkened_coat_color1.16169483
53MP0003453_abnormal_keratinocyte_physiol1.14076611
54MP0002876_abnormal_thyroid_physiology1.13969772
55MP0000467_abnormal_esophagus_morphology1.12428921
56MP0005670_abnormal_white_adipose1.09777266
57MP0009780_abnormal_chondrocyte_physiolo1.07910747
58MP0005535_abnormal_body_temperature1.02173384
59MP0008961_abnormal_basal_metabolism1.00363677
60MP0001216_abnormal_epidermal_layer0.96409868
61MP0008872_abnormal_physiological_respon0.94470871
62MP0002928_abnormal_bile_duct0.94047108
63MP0009764_decreased_sensitivity_to0.93266077
64MP0000465_gastrointestinal_hemorrhage0.93114676
65MP0004885_abnormal_endolymph0.92488858
66MP0002168_other_aberrant_phenotype0.91140577
67MP0009642_abnormal_blood_homeostasis0.89631631
68MP0003300_gastrointestinal_ulcer0.88429722
69MP0004185_abnormal_adipocyte_glucose0.87719489
70MP0000516_abnormal_urinary_system0.86771313
71MP0005367_renal/urinary_system_phenotyp0.86771313
72MP0000598_abnormal_liver_morphology0.86415361
73MP0005666_abnormal_adipose_tissue0.83997139
74MP0000230_abnormal_systemic_arterial0.82228360
75MP0002135_abnormal_kidney_morphology0.80777892
76MP0008469_abnormal_protein_level0.79139338
77MP0005448_abnormal_energy_balance0.78678208
78MP0003315_abnormal_perineum_morphology0.78610796
79MP0003329_amyloid_beta_deposits0.77202746
80MP0005408_hypopigmentation0.73891033
81MP0001501_abnormal_sleep_pattern0.73318541
82MP0003705_abnormal_hypodermis_morpholog0.72996194
83MP0002396_abnormal_hematopoietic_system0.72370870
84MP0004147_increased_porphyrin_level0.71330814
85MP0003172_abnormal_lysosome_physiology0.71043142
86MP0002896_abnormal_bone_mineralization0.69194336
87MP0003638_abnormal_response/metabolism_0.68787306
88MP0000604_amyloidosis0.67675837
89MP0005220_abnormal_exocrine_pancreas0.67421474
90MP0003693_abnormal_embryo_hatching0.67260225
91MP0002089_abnormal_postnatal_growth/wei0.66515876
92MP0002249_abnormal_larynx_morphology0.64141943
93MP0001485_abnormal_pinna_reflex0.63947101
94MP0003718_maternal_effect0.63612695
95MP0002078_abnormal_glucose_homeostasis0.63469226
96MP0001188_hyperpigmentation0.62741626
97MP0004264_abnormal_extraembryonic_tissu0.62339733
98MP0000470_abnormal_stomach_morphology0.62145296
99MP0005076_abnormal_cell_differentiation0.61994509
100MP0002796_impaired_skin_barrier0.60882129
101MP0005310_abnormal_salivary_gland0.60210976
102MP0005395_other_phenotype0.58312729
103MP0001661_extended_life_span0.57348992
104MP0000747_muscle_weakness0.56918488
105MP0010234_abnormal_vibrissa_follicle0.56087107
106MP0000377_abnormal_hair_follicle0.55301095
107MP0004947_skin_inflammation0.55062182
108MP0010771_integument_phenotype0.52334915
109MP0001849_ear_inflammation0.51902637
110MP0003045_fibrosis0.51332228
111MP0002166_altered_tumor_susceptibility0.50605353
112MP0006035_abnormal_mitochondrial_morpho0.49591911
113MP0002971_abnormal_brown_adipose0.49280894
114MP0009115_abnormal_fat_cell0.49147790
115MP0009763_increased_sensitivity_to0.48768379
116MP0002822_catalepsy0.48356495
117MP0003953_abnormal_hormone_level0.47680027
118MP0005257_abnormal_intraocular_pressure0.47654885
119MP0003868_abnormal_feces_composition0.47519681
120MP0009765_abnormal_xenobiotic_induced0.47228753
121MP0005376_homeostasis/metabolism_phenot0.46676802
122MP0002277_abnormal_respiratory_mucosa0.45109027
123MP0000371_diluted_coat_color0.43204605
124MP0003724_increased_susceptibility_to0.42740335
125MP0003690_abnormal_glial_cell0.41359991
126MP0000613_abnormal_salivary_gland0.40829477
127MP0003879_abnormal_hair_cell0.40804496
128MP0003075_altered_response_to0.40756143
129MP0009672_abnormal_birth_weight0.40512794
130MP0003283_abnormal_digestive_organ0.39012819
131MP0005167_abnormal_blood-brain_barrier0.38731408
132MP0005266_abnormal_metabolism0.38693621
133MP0005165_increased_susceptibility_to0.38426804
134MP0008874_decreased_physiological_sensi0.37292729
135MP0005647_abnormal_sex_gland0.37090192
136MP0005501_abnormal_skin_physiology0.36525677
137MP0003959_abnormal_lean_body0.35551916
138MP0005166_decreased_susceptibility_to0.33586089
139MP0001663_abnormal_digestive_system0.33026758
140MP0002069_abnormal_eating/drinking_beha0.32859149
141MP0002115_abnormal_skeleton_extremities0.32568658
142MP0003646_muscle_fatigue0.31934247
143MP0001845_abnormal_inflammatory_respons0.29404374
144MP0005334_abnormal_fat_pad0.29315502
145MP0005375_adipose_tissue_phenotype0.28897765
146MP0002837_dystrophic_cardiac_calcinosis0.27643240
147MP0002098_abnormal_vibrissa_morphology0.26452620
148MP0004782_abnormal_surfactant_physiolog0.26160786

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)6.61616576
2Abnormality of glutamine family amino acid metabolism (HP:0010902)5.61798865
3Increased circulating renin level (HP:0000848)5.29050953
4Decreased circulating renin level (HP:0003351)5.23297420
5Hyperglycinuria (HP:0003108)5.21020196
6Metabolic alkalosis (HP:0200114)5.17402630
7Proximal tubulopathy (HP:0000114)5.16629542
8Hypokalemic alkalosis (HP:0001949)5.09433892
9Polyuria (HP:0000103)4.98986790
10Ileus (HP:0002595)4.88507166
11Hyperactive renin-angiotensin system (HP:0000841)4.88153569
12Abnormal urine output (HP:0012590)4.76115955
13Abnormality of renal excretion (HP:0011036)4.61264172
14Increased purine levels (HP:0004368)4.60555605
15Hyperuricemia (HP:0002149)4.60555605
16Abnormality of purine metabolism (HP:0004352)4.55487495
17Hypomagnesemia (HP:0002917)4.53978841
18Abnormality of serine family amino acid metabolism (HP:0010894)4.51991168
19Abnormality of glycine metabolism (HP:0010895)4.51991168
20Generalized aminoaciduria (HP:0002909)4.51210890
21Abnormality of chloride homeostasis (HP:0011422)4.48125867
22Abnormality of aromatic amino acid family metabolism (HP:0004338)4.41286921
23Focal segmental glomerulosclerosis (HP:0000097)4.31227828
24Ketosis (HP:0001946)4.16843042
25Alkalosis (HP:0001948)4.06609429
26Right ventricular cardiomyopathy (HP:0011663)3.97535740
27Ketoacidosis (HP:0001993)3.87855550
28Abnormality of the vitamin B12 metabolism (HP:0004341)3.85529568
29Abdominal distention (HP:0003270)3.82136365
30Abnormality of magnesium homeostasis (HP:0004921)3.82102241
31Abnormal drinking behavior (HP:0030082)3.79244907
32Polydipsia (HP:0001959)3.79244907
33Abnormality of nucleobase metabolism (HP:0010932)3.78007869
34Facial shape deformation (HP:0011334)3.77142071
35Potter facies (HP:0002009)3.77142071
36Glycosuria (HP:0003076)3.74151860
37Abnormality of urine glucose concentration (HP:0011016)3.74151860
38Chronic diarrhea (HP:0002028)3.72148686
39Abnormality of vitamin B metabolism (HP:0004340)3.71995342
40Delayed CNS myelination (HP:0002188)3.70102352
41Hyperglycinemia (HP:0002154)3.66151670
42Hypobetalipoproteinemia (HP:0003563)3.65632380
43Hyperammonemia (HP:0001987)3.62084030
44Glomerulosclerosis (HP:0000096)3.54943577
45Intrahepatic cholestasis (HP:0001406)3.54640146
46Flat acetabular roof (HP:0003180)3.53745784
47Hydroxyprolinuria (HP:0003080)3.53538462
48Abnormality of proline metabolism (HP:0010907)3.53538462
49Abnormality of aspartate family amino acid metabolism (HP:0010899)3.52795462
50Wide cranial sutures (HP:0010537)3.43841059
51Hypercalciuria (HP:0002150)3.40300553
52Abnormality of vitamin metabolism (HP:0100508)3.37890806
53Hemorrhage of the eye (HP:0011885)3.32944307
54Pigmentary retinal degeneration (HP:0001146)3.32111369
55Abnormality of renin-angiotensin system (HP:0000847)3.26863856
56Xanthomatosis (HP:0000991)3.25550687
57Renal salt wasting (HP:0000127)3.25044428
58Abnormality of monocarboxylic acid metabolism (HP:0010996)3.24098702
59Conjugated hyperbilirubinemia (HP:0002908)3.21985342
60Hyperphosphaturia (HP:0003109)3.21911834
61Abnormality of fatty-acid metabolism (HP:0004359)3.18006865
62Vascular calcification (HP:0004934)3.16777594
63Renal tubular acidosis (HP:0001947)3.16247461
64Hyperaldosteronism (HP:0000859)3.15474968
65Abnormality of sulfur amino acid metabolism (HP:0004339)3.07626844
66Hyponatremia (HP:0002902)3.06396358
67Hypotension (HP:0002615)3.04374655
68Abnormal urine phosphate concentration (HP:0012599)3.02719683
69Acanthocytosis (HP:0001927)2.98348854
70Dicarboxylic aciduria (HP:0003215)2.97411152
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97411152
72Nephrolithiasis (HP:0000787)2.96352557
73Rickets (HP:0002748)2.92792573
74Tetany (HP:0001281)2.89211952
75Delayed epiphyseal ossification (HP:0002663)2.88056348
76Hypophosphatemia (HP:0002148)2.83486694
77Cardiovascular calcification (HP:0011915)2.83102801
78Pili torti (HP:0003777)2.82153755
79Malnutrition (HP:0004395)2.81635288
80Abnormality of small intestinal villus morphology (HP:0011472)2.79730804
81Villous atrophy (HP:0011473)2.79730804
82Metabolic acidosis (HP:0001942)2.73556041
83Abnormal enzyme/coenzyme activity (HP:0012379)2.72205774
84Congenital sensorineural hearing impairment (HP:0008527)2.61002068
85Lethargy (HP:0001254)2.60824645
86Vomiting (HP:0002013)2.60505482
87Nephrocalcinosis (HP:0000121)2.60337313
88Abnormality of alkaline phosphatase activity (HP:0004379)2.58894023
89Deep venous thrombosis (HP:0002625)2.55534273
90Abnormal hair laboratory examination (HP:0003328)2.52009498
91Hyperkalemia (HP:0002153)2.48013462
92Enlarged kidneys (HP:0000105)2.45485204
93Hypokalemia (HP:0002900)2.44695501
94Irritability (HP:0000737)2.42310116
95Confusion (HP:0001289)2.41776308
96Sensorimotor neuropathy (HP:0007141)2.40861082
97Abnormality of serum amino acid levels (HP:0003112)2.40404975
98Curly hair (HP:0002212)2.39937320
99Vacuolated lymphocytes (HP:0001922)2.39487437
100Hypoglycemic coma (HP:0001325)2.39121643
101Widely patent fontanelles and sutures (HP:0004492)2.37201512
102Methylmalonic aciduria (HP:0012120)2.37187642
103Subcapsular cataract (HP:0000523)2.34328619
104Steatorrhea (HP:0002570)2.33317969
105Metaphyseal cupping (HP:0003021)2.32876435
106Neonatal onset (HP:0003623)2.31135964
107Abnormal biliary tract morphology (HP:0012440)2.29830673
108Abnormal tarsal ossification (HP:0008369)2.29197463
109Elevated alkaline phosphatase (HP:0003155)2.25693587
110Hypolipoproteinemia (HP:0010981)2.24238829
111Abnormality of pyrimidine metabolism (HP:0004353)2.23048617
112Tubular atrophy (HP:0000092)2.21336951
113Spastic diplegia (HP:0001264)2.13906735
114Dehydration (HP:0001944)2.11223726
115Abnormality of potassium homeostasis (HP:0011042)2.09737118
116Hepatocellular carcinoma (HP:0001402)2.09427650
117Nausea (HP:0002018)2.09347708
118Late onset (HP:0003584)2.09008518
119Posterior subcapsular cataract (HP:0007787)2.07815018
120Abnormality of sodium homeostasis (HP:0010931)2.06848779
121Lymphangioma (HP:0100764)2.05260906
122Renal tubular dysfunction (HP:0000124)2.01350849
123Woolly hair (HP:0002224)2.00375206
124Thin bony cortex (HP:0002753)1.99630725
125Hypophosphatemic rickets (HP:0004912)1.99296302
126Adrenal overactivity (HP:0002717)1.97260111
127Hyperparathyroidism (HP:0000843)1.96532204
128Abnormality of renal resorption (HP:0011038)1.95699187
129Hyperphosphatemia (HP:0002905)1.95063774
130Axonal loss (HP:0003447)1.94528491
131Abnormality of the costochondral junction (HP:0000919)1.92280610
132Fat malabsorption (HP:0002630)1.92089864
133Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91956579
134Paraparesis (HP:0002385)1.90014851
135Joint hemorrhage (HP:0005261)1.89409323
136Enlarged epiphyses (HP:0010580)1.87493282
137Chronic bronchitis (HP:0004469)1.86459906
138Hyperventilation (HP:0002883)1.86033989
139Cerebral edema (HP:0002181)1.85636207
140Bilateral sensorineural hearing impairment (HP:0008619)1.85263876
141Abnormality of the distal phalanx of the thumb (HP:0009617)1.83885427
142Tachypnea (HP:0002789)1.83218292
143Distal lower limb amyotrophy (HP:0008944)1.82157388
144Complement deficiency (HP:0004431)1.79660927
145Hyperbilirubinemia (HP:0002904)1.79248464
146Petechiae (HP:0000967)1.77060562
147Megaloblastic anemia (HP:0001889)1.76576076
148Neonatal short-limb short stature (HP:0008921)1.75036301
149Syncope (HP:0001279)1.74877103
150Palpitations (HP:0001962)1.73560008
151Hypoalbuminemia (HP:0003073)1.73283374
152Abnormal albumin level (HP:0012116)1.73283374
153Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.72862068

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.92107294
2WNK36.98506567
3EPHA26.71039966
4OXSR15.90002987
5BCKDK5.42242432
6LMTK24.69347293
7ACVR1B4.23417574
8STK392.98768821
9EPHB22.67589796
10STK38L2.64034113
11FGFR42.48386105
12PRKG22.26214374
13PIK3CA2.16967382
14MAP3K102.12714020
15PDK42.10612352
16PDK32.10612352
17NEK12.05488259
18ERN11.90755009
19WNK11.78897928
20SGK4941.69244621
21SGK2231.69244621
22MST1R1.66223301
23STK241.48614842
24MAP3K121.45748847
25STK381.45076758
26EPHB11.44448850
27GRK61.32204775
28PDK21.31502574
29SIK11.09378643
30PINK11.03590677
31TRIB31.01660806
32GSK3A0.97420944
33MAPK110.96686012
34DYRK1B0.94110093
35ERBB40.93854304
36PTK60.93600733
37DDR20.91508777
38LRRK20.90580895
39MAP3K70.89049216
40ABL20.88692192
41RPS6KB20.81722793
42MAP2K20.81458275
43PTK20.79751850
44IRAK40.78565882
45TAOK10.77151751
46SGK30.76467692
47PHKG10.75320744
48PHKG20.75320744
49MST40.74870825
50MAP2K40.73723154
51CAMK2D0.73335630
52INSRR0.72849359
53TESK10.69131874
54PIK3CG0.64809486
55MAP2K60.64451186
56MATK0.64102372
57SGK20.63445330
58TIE10.63358093
59PDPK10.62316917
60MAP3K30.60141057
61TGFBR20.59588554
62PRKAA10.56322180
63MET0.54823729
64TNIK0.54137981
65PRKAA20.53565030
66PRKCZ0.53198992
67SGK10.52341380
68PAK30.50704932
69PAK40.50449605
70TESK20.50350240
71MAP3K140.50097323
72LATS10.49867422
73JAK20.48747919
74RPS6KA40.46622643
75RIPK10.46307972
76PKN20.45190110
77TYK20.44464431
78CDK80.43925932
79PDK10.42449928
80FER0.40581497
81FRK0.40343296
82MAP2K30.39465491
83PRKACG0.39453492
84MAP3K10.38324041
85EPHA40.37363798
86NTRK10.37301546
87MAP4K10.37023671
88PTK2B0.36548924
89FGFR30.36197872
90AKT30.36141251
91IRAK30.36128438
92CAMK2B0.35901853
93MAP3K110.35577853
94MAPK150.35426299
95CDC42BPA0.34716842
96MAPKAPK30.32491866
97DAPK20.31729315
98STK100.30079083
99IRAK20.29966308
100BRSK20.29906319
101NEK90.28390591
102MAPKAPK20.27943930
103CDK90.27789813
104MAPK120.27489037
105TAOK30.26775521
106CSK0.26366958
107PRPF4B0.26333142
108GRK10.26175555
109PRKCD0.25852801
110PRKCH0.25034698
111MAP3K20.24852726
112MAPK40.24838457
113KDR0.24726229
114PRKCE0.24511375
115SRC0.22870834
116MELK0.22861347
117BMX0.22288877
118IRAK10.22228962
119STK30.21319873
120TBK10.20583270
121PRKCI0.20270294
122ERBB20.20096374
123PRKCA0.19915355
124PRKCG0.19655265
125PRKCQ0.18537853
126CSF1R0.18330664
127PRKD20.18064897
128STK110.17703327
129ICK0.17064500
130CSNK1A10.17033924
131JAK10.15207168
132DAPK10.14559009
133MYLK0.14025673
134NME20.13371821
135PRKACA0.13365647
136AKT20.13239588
137NME10.12928404
138TRIM280.12177532
139ARAF0.11991127
140MAP2K10.11399018
141CAMK40.10516469
142GRK50.09787500
143CAMK2G0.09672595
144MTOR0.09564751
145IGF1R0.09554622
146KSR20.09360689
147EGFR0.09171187
148MINK10.07911306
149DMPK0.07810364
150ILK0.06750774
151FYN0.04963727
152AURKB0.04430524

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.42071929
2Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.35783288
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.23032374
4* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07588096
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.00574115
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.96781691
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.88686793
8Propanoate metabolism_Homo sapiens_hsa006402.82122005
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.77775998
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.75509001
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.62707264
12Tryptophan metabolism_Homo sapiens_hsa003802.62147226
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.58162648
14* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.52140324
15Fatty acid degradation_Homo sapiens_hsa000712.49800816
16Peroxisome_Homo sapiens_hsa041462.48654359
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47609979
18Nitrogen metabolism_Homo sapiens_hsa009102.30837816
19Arginine biosynthesis_Homo sapiens_hsa002202.27402894
20Pyruvate metabolism_Homo sapiens_hsa006202.17651971
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15961366
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00998761
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86317845
24Fatty acid metabolism_Homo sapiens_hsa012121.85960833
25beta-Alanine metabolism_Homo sapiens_hsa004101.85082998
26Sulfur metabolism_Homo sapiens_hsa009201.84608032
27Vitamin digestion and absorption_Homo sapiens_hsa049771.68553528
28Bile secretion_Homo sapiens_hsa049761.66314557
29Carbon metabolism_Homo sapiens_hsa012001.64595006
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54330527
31Linoleic acid metabolism_Homo sapiens_hsa005911.51544898
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48342050
33Histidine metabolism_Homo sapiens_hsa003401.45506545
34Arginine and proline metabolism_Homo sapiens_hsa003301.44707134
35PPAR signaling pathway_Homo sapiens_hsa033201.44370490
36Glutathione metabolism_Homo sapiens_hsa004801.30799038
37* Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30768077
38Selenocompound metabolism_Homo sapiens_hsa004501.27419287
39Phenylalanine metabolism_Homo sapiens_hsa003601.26832928
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24917902
41Biosynthesis of amino acids_Homo sapiens_hsa012301.24742490
42Folate biosynthesis_Homo sapiens_hsa007901.14509662
43Lysine degradation_Homo sapiens_hsa003101.12804411
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11295218
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08348691
46* Steroid hormone biosynthesis_Homo sapiens_hsa001401.07822193
47Complement and coagulation cascades_Homo sapiens_hsa046101.07252800
48Collecting duct acid secretion_Homo sapiens_hsa049661.06484987
49* Starch and sucrose metabolism_Homo sapiens_hsa005001.04375848
50Fatty acid elongation_Homo sapiens_hsa000620.99176220
51* Chemical carcinogenesis_Homo sapiens_hsa052040.97173437
52Fatty acid biosynthesis_Homo sapiens_hsa000610.94650314
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.94605420
54Pancreatic secretion_Homo sapiens_hsa049720.93966602
55* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91591078
56Steroid biosynthesis_Homo sapiens_hsa001000.90931106
57* Drug metabolism - other enzymes_Homo sapiens_hsa009830.84402719
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.84026606
59Tyrosine metabolism_Homo sapiens_hsa003500.83879316
60Glycerolipid metabolism_Homo sapiens_hsa005610.82991124
61Ether lipid metabolism_Homo sapiens_hsa005650.81595499
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73315815
63* Retinol metabolism_Homo sapiens_hsa008300.72373419
64Pentose phosphate pathway_Homo sapiens_hsa000300.72180341
65Protein digestion and absorption_Homo sapiens_hsa049740.69551849
66Sphingolipid metabolism_Homo sapiens_hsa006000.67475236
67Fructose and mannose metabolism_Homo sapiens_hsa000510.65454759
68Mineral absorption_Homo sapiens_hsa049780.64374454
69Other glycan degradation_Homo sapiens_hsa005110.62807833
70ABC transporters_Homo sapiens_hsa020100.58705123
71Sulfur relay system_Homo sapiens_hsa041220.56542016
72Renin secretion_Homo sapiens_hsa049240.54414136
73* Metabolic pathways_Homo sapiens_hsa011000.53538935
74Tight junction_Homo sapiens_hsa045300.52523823
75Staphylococcus aureus infection_Homo sapiens_hsa051500.49698820
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48824483
77Caffeine metabolism_Homo sapiens_hsa002320.48366865
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45678584
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43848094
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43376643
81One carbon pool by folate_Homo sapiens_hsa006700.38181100
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36813715
83Fat digestion and absorption_Homo sapiens_hsa049750.36693290
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.35714923
85Lysosome_Homo sapiens_hsa041420.32585034
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32170397
87Vitamin B6 metabolism_Homo sapiens_hsa007500.30228456
88Thyroid hormone synthesis_Homo sapiens_hsa049180.27308665
89Oxidative phosphorylation_Homo sapiens_hsa001900.25411604
90N-Glycan biosynthesis_Homo sapiens_hsa005100.25193111
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23677981
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.22645745
93* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21053828
94Arachidonic acid metabolism_Homo sapiens_hsa005900.20463891
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19958895
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.14981077
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.14355585
98Insulin resistance_Homo sapiens_hsa049310.14209790
99Hepatitis C_Homo sapiens_hsa051600.14165421
100Galactose metabolism_Homo sapiens_hsa000520.12656928
101Renin-angiotensin system_Homo sapiens_hsa046140.12082718
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10448022
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06274361
104Parkinsons disease_Homo sapiens_hsa050120.05085238
105Adherens junction_Homo sapiens_hsa045200.03188883
106Glucagon signaling pathway_Homo sapiens_hsa049220.02016190
107Insulin secretion_Homo sapiens_hsa049110.01513504
108Ovarian steroidogenesis_Homo sapiens_hsa049130.00632435
109Thyroid cancer_Homo sapiens_hsa052160.00561734
110AMPK signaling pathway_Homo sapiens_hsa041520.00185143
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1582936
112Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1505066
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.1362942
114Synaptic vesicle cycle_Homo sapiens_hsa04721-0.1233518
115Prion diseases_Homo sapiens_hsa05020-0.1199148
116Amphetamine addiction_Homo sapiens_hsa05031-0.1101813
117Alzheimers disease_Homo sapiens_hsa05010-0.1092745
118Pathogenic Escherichia coli infection_Homo sapiens_hsa05130-0.1029909
119Serotonergic synapse_Homo sapiens_hsa04726-0.0956808
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0903799
121Choline metabolism in cancer_Homo sapiens_hsa05231-0.0825302
122Insulin signaling pathway_Homo sapiens_hsa04910-0.0813168
123Vibrio cholerae infection_Homo sapiens_hsa05110-0.0737530
124Asthma_Homo sapiens_hsa05310-0.0723287
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0585825
126Cocaine addiction_Homo sapiens_hsa05030-0.0316373
127Gastric acid secretion_Homo sapiens_hsa04971-0.0028496

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