Rank | Gene Set | Z-score |
---|---|---|
1 | angiotensin maturation (GO:0002003) | 9.32780510 |
2 | drug transmembrane transport (GO:0006855) | 8.63296303 |
3 | urate metabolic process (GO:0046415) | 8.17636459 |
4 | aminoglycoside antibiotic metabolic process (GO:0030647) | 7.96461375 |
5 | glyoxylate metabolic process (GO:0046487) | 7.92257563 |
6 | lysine catabolic process (GO:0006554) | 7.75959801 |
7 | lysine metabolic process (GO:0006553) | 7.75959801 |
8 | drug transport (GO:0015893) | 7.32477239 |
9 | * cellular glucuronidation (GO:0052695) | 6.85581193 |
10 | intestinal absorption (GO:0050892) | 6.81589017 |
11 | organic cation transport (GO:0015695) | 6.69646771 |
12 | cysteine metabolic process (GO:0006534) | 6.68932567 |
13 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 6.64087001 |
14 | L-phenylalanine catabolic process (GO:0006559) | 6.64087001 |
15 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 6.55761352 |
16 | L-phenylalanine metabolic process (GO:0006558) | 6.55761352 |
17 | * glucuronate metabolic process (GO:0019585) | 6.52042724 |
18 | * uronic acid metabolic process (GO:0006063) | 6.52042724 |
19 | aromatic amino acid family catabolic process (GO:0009074) | 6.40350759 |
20 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 6.34107295 |
21 | phosphate ion transport (GO:0006817) | 6.15686581 |
22 | indole-containing compound catabolic process (GO:0042436) | 6.15349587 |
23 | indolalkylamine catabolic process (GO:0046218) | 6.15349587 |
24 | tryptophan catabolic process (GO:0006569) | 6.15349587 |
25 | * flavonoid metabolic process (GO:0009812) | 6.14580641 |
26 | regulation of guanylate cyclase activity (GO:0031282) | 5.94249236 |
27 | drug catabolic process (GO:0042737) | 5.90364522 |
28 | exogenous drug catabolic process (GO:0042738) | 5.84350008 |
29 | bile acid and bile salt transport (GO:0015721) | 5.84251153 |
30 | response to mercury ion (GO:0046689) | 5.82925872 |
31 | tryptophan metabolic process (GO:0006568) | 5.78247309 |
32 | epoxygenase P450 pathway (GO:0019373) | 5.72109803 |
33 | sulfate transmembrane transport (GO:1902358) | 5.71846576 |
34 | serine family amino acid catabolic process (GO:0009071) | 5.66924358 |
35 | quaternary ammonium group transport (GO:0015697) | 5.61978036 |
36 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 5.57434959 |
37 | short-chain fatty acid metabolic process (GO:0046459) | 5.55106869 |
38 | citrulline biosynthetic process (GO:0019240) | 5.55010052 |
39 | regulation of bile acid biosynthetic process (GO:0070857) | 5.51846371 |
40 | desmosome organization (GO:0002934) | 5.47869299 |
41 | phenylpropanoid metabolic process (GO:0009698) | 5.41815018 |
42 | aspartate family amino acid catabolic process (GO:0009068) | 5.41104300 |
43 | tricarboxylic acid metabolic process (GO:0072350) | 5.40043629 |
44 | drinking behavior (GO:0042756) | 5.18989195 |
45 | cellular modified amino acid catabolic process (GO:0042219) | 5.15107633 |
46 | serine family amino acid metabolic process (GO:0009069) | 5.08367202 |
47 | phosphate ion transmembrane transport (GO:0035435) | 5.07038900 |
48 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 5.04018173 |
49 | kynurenine metabolic process (GO:0070189) | 4.94613055 |
50 | homocysteine metabolic process (GO:0050667) | 4.94111932 |
51 | amino-acid betaine metabolic process (GO:0006577) | 4.88243749 |
52 | fat-soluble vitamin biosynthetic process (GO:0042362) | 4.85101975 |
53 | lipoprotein transport (GO:0042953) | 4.83456272 |
54 | sulfur amino acid catabolic process (GO:0000098) | 4.77007386 |
55 | sulfate transport (GO:0008272) | 4.75673590 |
56 | branched-chain amino acid metabolic process (GO:0009081) | 4.75037021 |
57 | aromatic amino acid family metabolic process (GO:0009072) | 4.68158070 |
58 | proline metabolic process (GO:0006560) | 4.63445874 |
59 | vitamin D metabolic process (GO:0042359) | 4.61809711 |
60 | serine family amino acid biosynthetic process (GO:0009070) | 4.59918233 |
61 | cellular ketone body metabolic process (GO:0046950) | 4.59239341 |
62 | alpha-amino acid catabolic process (GO:1901606) | 4.58411312 |
63 | glutamate metabolic process (GO:0006536) | 4.56319290 |
64 | 2-oxoglutarate metabolic process (GO:0006103) | 4.54267428 |
65 | cellular amino acid catabolic process (GO:0009063) | 4.53659094 |
66 | nonribosomal peptide biosynthetic process (GO:0019184) | 4.49803659 |
67 | regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) | 4.48979822 |
68 | endocrine process (GO:0050886) | 4.48979822 |
69 | regulation of systemic arterial blood pressure by hormone (GO:0001990) | 4.48979822 |
70 | renal system process involved in regulation of blood volume (GO:0001977) | 4.47641691 |
71 | renal system process involved in regulation of systemic arterial blood pressure (GO:0003071) | 4.39667136 |
72 | acetyl-CoA metabolic process (GO:0006084) | 4.35751680 |
73 | positive regulation of guanylate cyclase activity (GO:0031284) | 4.32391973 |
74 | valine metabolic process (GO:0006573) | 4.31518825 |
75 | indolalkylamine metabolic process (GO:0006586) | 4.30854010 |
76 | bile acid biosynthetic process (GO:0006699) | 4.29248500 |
77 | fatty acid beta-oxidation (GO:0006635) | 4.21413990 |
78 | hormone catabolic process (GO:0042447) | 4.19755011 |
79 | citrulline metabolic process (GO:0000052) | 4.17881456 |
80 | phosphate ion homeostasis (GO:0055062) | 4.17110329 |
81 | trivalent inorganic anion homeostasis (GO:0072506) | 4.17110329 |
82 | regulation of systemic arterial blood pressure (GO:0003073) | 4.17108612 |
83 | fatty acid oxidation (GO:0019395) | 4.14135307 |
84 | amino-acid betaine transport (GO:0015838) | 4.12338085 |
85 | carnitine transport (GO:0015879) | 4.12338085 |
86 | glutathione biosynthetic process (GO:0006750) | 4.09844659 |
87 | lipid oxidation (GO:0034440) | 4.06368020 |
88 | excretion (GO:0007588) | 4.04435389 |
89 | cellular biogenic amine catabolic process (GO:0042402) | 4.04265399 |
90 | amine catabolic process (GO:0009310) | 4.04265399 |
91 | fructose metabolic process (GO:0006000) | 4.02856961 |
92 | peptide hormone processing (GO:0016486) | 4.00853287 |
93 | branched-chain amino acid catabolic process (GO:0009083) | 4.00014361 |
94 | carnitine metabolic process (GO:0009437) | 3.98645871 |
95 | organic acid catabolic process (GO:0016054) | 3.98092952 |
96 | carboxylic acid catabolic process (GO:0046395) | 3.98092952 |
97 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.97467575 |
98 | indole-containing compound metabolic process (GO:0042430) | 3.97463393 |
99 | benzene-containing compound metabolic process (GO:0042537) | 3.96763141 |
100 | aldehyde catabolic process (GO:0046185) | 3.95897600 |
101 | ketone body metabolic process (GO:1902224) | 3.95408072 |
102 | O-glycan processing (GO:0016266) | 3.90420680 |
103 | regulation of vitamin metabolic process (GO:0030656) | 3.89000496 |
104 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 3.85564698 |
105 | alkaloid metabolic process (GO:0009820) | 3.82129216 |
106 | intestinal epithelial cell development (GO:0060576) | 3.78850754 |
107 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) | 3.77343993 |
108 | ethanol oxidation (GO:0006069) | 3.77121071 |
109 | renal absorption (GO:0070293) | 3.75922052 |
110 | digestion (GO:0007586) | 3.74291605 |
111 | monocarboxylic acid catabolic process (GO:0072329) | 3.72370704 |
112 | fatty acid catabolic process (GO:0009062) | 3.71789526 |
113 | drug metabolic process (GO:0017144) | 3.71602790 |
114 | regulation of triglyceride catabolic process (GO:0010896) | 3.68200568 |
115 | receptor guanylyl cyclase signaling pathway (GO:0007168) | 3.67125217 |
116 | modified amino acid transport (GO:0072337) | 3.67048061 |
117 | dicarboxylic acid metabolic process (GO:0043648) | 3.62546668 |
118 | sodium-independent organic anion transport (GO:0043252) | 3.60551707 |
119 | sulfur compound transport (GO:0072348) | 3.57193509 |
120 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 3.56354901 |
121 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 3.56354901 |
122 | regulation of cholesterol homeostasis (GO:2000188) | 3.54887180 |
123 | alpha-linolenic acid metabolic process (GO:0036109) | 3.53950692 |
124 | daunorubicin metabolic process (GO:0044597) | 3.53654494 |
125 | polyketide metabolic process (GO:0030638) | 3.53654494 |
126 | doxorubicin metabolic process (GO:0044598) | 3.53654494 |
127 | glutathione metabolic process (GO:0006749) | 3.53089217 |
128 | response to growth hormone (GO:0060416) | 3.51357482 |
129 | tyrosine metabolic process (GO:0006570) | 3.50760258 |
130 | urea cycle (GO:0000050) | 3.50597627 |
131 | urea metabolic process (GO:0019627) | 3.50597627 |
132 | glutamine family amino acid catabolic process (GO:0009065) | 3.49790792 |
133 | toxin transport (GO:1901998) | 3.47012641 |
134 | small molecule catabolic process (GO:0044282) | 3.43460405 |
135 | maintenance of gastrointestinal epithelium (GO:0030277) | 3.43312243 |
136 | glycine metabolic process (GO:0006544) | 3.42669354 |
137 | metanephric nephron tubule development (GO:0072234) | 3.41863330 |
138 | metanephric tubule development (GO:0072170) | 3.41863330 |
139 | cyclooxygenase pathway (GO:0019371) | 3.40798394 |
140 | vitamin transmembrane transport (GO:0035461) | 3.40416630 |
141 | positive regulation of lipid catabolic process (GO:0050996) | 3.39587712 |
142 | positive regulation of pseudopodium assembly (GO:0031274) | 3.39229209 |
143 | coenzyme catabolic process (GO:0009109) | 3.38837307 |
144 | bile acid metabolic process (GO:0008206) | 3.36750968 |
145 | regulation of cGMP biosynthetic process (GO:0030826) | 3.36370554 |
146 | positive regulation of fatty acid oxidation (GO:0046321) | 3.34658629 |
147 | nitrogen cycle metabolic process (GO:0071941) | 3.33966690 |
148 | transcytosis (GO:0045056) | 3.32249548 |
149 | response to phenylpropanoid (GO:0080184) | 3.31844583 |
150 | vitamin transport (GO:0051180) | 3.31376232 |
151 | phenol-containing compound catabolic process (GO:0019336) | 3.29746840 |
152 | NADH metabolic process (GO:0006734) | 3.26716461 |
153 | auditory receptor cell differentiation (GO:0042491) | 3.24468181 |
154 | glycoside metabolic process (GO:0016137) | 3.23721870 |
155 | sodium ion homeostasis (GO:0055078) | 3.23682949 |
156 | peptide biosynthetic process (GO:0043043) | 3.23234809 |
157 | negative regulation of steroid metabolic process (GO:0045939) | 3.19250056 |
158 | digestive system process (GO:0022600) | 3.17276690 |
159 | thrombin receptor signaling pathway (GO:0070493) | 3.16426887 |
160 | primary alcohol catabolic process (GO:0034310) | 3.15620108 |
161 | positive regulation of respiratory burst (GO:0060267) | 3.15553212 |
162 | glutamine family amino acid biosynthetic process (GO:0009084) | 3.15201168 |
163 | positive regulation of Cdc42 GTPase activity (GO:0043089) | 3.14662473 |
164 | arginine metabolic process (GO:0006525) | 3.13337811 |
165 | regulation of cellular extravasation (GO:0002691) | 3.09379553 |
166 | diacylglycerol metabolic process (GO:0046339) | 3.07168366 |
167 | regulation of viral release from host cell (GO:1902186) | 3.02589349 |
168 | glucose 6-phosphate metabolic process (GO:0051156) | 3.02026611 |
169 | multicellular organismal water homeostasis (GO:0050891) | 2.98873969 |
170 | regulation of pseudopodium assembly (GO:0031272) | 2.98339822 |
171 | glycerol metabolic process (GO:0006071) | 2.96620249 |
172 | sphingomyelin metabolic process (GO:0006684) | 2.95667933 |
173 | glycosphingolipid catabolic process (GO:0046479) | 2.94194020 |
174 | glycolipid catabolic process (GO:0019377) | 2.92626727 |
175 | GDP-mannose metabolic process (GO:0019673) | 2.91771449 |
176 | regulation of cholesterol metabolic process (GO:0090181) | 2.91564338 |
177 | regulation of protein glycosylation (GO:0060049) | 2.89048308 |
178 | ethanol metabolic process (GO:0006067) | 2.84375976 |
179 | nucleoside diphosphate biosynthetic process (GO:0009133) | 2.82903746 |
180 | glucocorticoid biosynthetic process (GO:0006704) | 2.82361290 |
181 | retinoic acid metabolic process (GO:0042573) | 2.80823138 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 9.82662696 |
2 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 7.30661784 |
3 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 6.27918281 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 5.44556772 |
5 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.95103975 |
6 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 4.69110919 |
7 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 4.43328446 |
8 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 3.66219664 |
9 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.29071907 |
10 | * SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.95267931 |
11 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.82844033 |
12 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.74420045 |
13 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.69087080 |
14 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.57916489 |
15 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.41123963 |
16 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.39220534 |
17 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 2.19177442 |
18 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 2.17574294 |
19 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 2.07550138 |
20 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.05740559 |
21 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.97305060 |
22 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.96236738 |
23 | KLF5_25053715_ChIP-Seq_YYC3_Human | 1.94655737 |
24 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.81784501 |
25 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.78903244 |
26 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.77361328 |
27 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.76394637 |
28 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.72095532 |
29 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.71895633 |
30 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.71845333 |
31 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.67437026 |
32 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.66455023 |
33 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.65889030 |
34 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.62752382 |
35 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.61481022 |
36 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.58708803 |
37 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.45254783 |
38 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.43091419 |
39 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 1.38642636 |
40 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.38359385 |
41 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.38110508 |
42 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.37513595 |
43 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.36800398 |
44 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.35640237 |
45 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.35233850 |
46 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.30676454 |
47 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 1.26856549 |
48 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.23694660 |
49 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.22955372 |
50 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.22100611 |
51 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.20329234 |
52 | * SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.17868686 |
53 | * SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.17868686 |
54 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.17790622 |
55 | ATF3_27146783_Chip-Seq_COLON_Human | 1.11183340 |
56 | * TP63_22573176_ChIP-Seq_HFKS_Human | 1.09598345 |
57 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 1.07314818 |
58 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.06363607 |
59 | * IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.05998752 |
60 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.05056841 |
61 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.01790875 |
62 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.00365382 |
63 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.97573284 |
64 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.96852515 |
65 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.95902739 |
66 | SA1_27219007_Chip-Seq_Bcells_Human | 0.95479297 |
67 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.94963516 |
68 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.94718238 |
69 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.94532634 |
70 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.93977630 |
71 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.92847454 |
72 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.92711875 |
73 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.92666472 |
74 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.91317849 |
75 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.90259278 |
76 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.87481450 |
77 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.87036648 |
78 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.86810177 |
79 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.85816453 |
80 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.85178517 |
81 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.84678467 |
82 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.84198071 |
83 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.84107631 |
84 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.83463237 |
85 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.82898956 |
86 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.82898956 |
87 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.82571038 |
88 | TP63_23658742_ChIP-Seq_EP156T_Human | 0.81818207 |
89 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.81659922 |
90 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.81526531 |
91 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.79906526 |
92 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.78148292 |
93 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.77357597 |
94 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.75330537 |
95 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.74954304 |
96 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.74847262 |
97 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.74600149 |
98 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.72390356 |
99 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.71871290 |
100 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.71864407 |
101 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.71427332 |
102 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.71074606 |
103 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.70472031 |
104 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.68634819 |
105 | * SOX2_20726797_ChIP-Seq_SW620_Human | 0.68150181 |
106 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.67360809 |
107 | * ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.66766057 |
108 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.66261674 |
109 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.65887525 |
110 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.65327571 |
111 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.65107512 |
112 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.65107512 |
113 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.64845026 |
114 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.63991519 |
115 | AR_20517297_ChIP-Seq_VCAP_Human | 0.63451454 |
116 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.63388530 |
117 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.62627492 |
118 | * CEBPB_22108803_ChIP-Seq_LS180_Human | 0.62306674 |
119 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.61778760 |
120 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.61623672 |
121 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.61167046 |
122 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.61165802 |
123 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.59900632 |
124 | GATA2_19941826_ChIP-Seq_K562_Human | 0.59093786 |
125 | * RAC3_21632823_ChIP-Seq_H3396_Human | 0.58513332 |
126 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.58021647 |
127 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.57155571 |
128 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.56837816 |
129 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.56739425 |
130 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.56696429 |
131 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.56647379 |
132 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.56644238 |
133 | RXR_22108803_ChIP-Seq_LS180_Human | 0.55807107 |
134 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.55633053 |
135 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.55581385 |
136 | CBP_21632823_ChIP-Seq_H3396_Human | 0.55476584 |
137 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.54226685 |
138 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.54166675 |
139 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.53531705 |
140 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.53473404 |
141 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.53125899 |
142 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.52514461 |
143 | * GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.51808342 |
144 | P68_20966046_ChIP-Seq_HELA_Human | 0.51581916 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005360_urolithiasis | 8.97566622 |
2 | MP0002139_abnormal_hepatobiliary_system | 6.97370694 |
3 | MP0005332_abnormal_amino_acid | 4.64108027 |
4 | MP0004019_abnormal_vitamin_homeostasis | 4.39445192 |
5 | MP0004043_abnormal_pH_regulation | 4.28903116 |
6 | MP0005085_abnormal_gallbladder_physiolo | 4.09033633 |
7 | MP0008875_abnormal_xenobiotic_pharmacok | 4.04977152 |
8 | MP0005365_abnormal_bile_salt | 4.02162887 |
9 | MP0003195_calcinosis | 3.61253519 |
10 | MP0002138_abnormal_hepatobiliary_system | 3.27130230 |
11 | MP0009643_abnormal_urine_homeostasis | 3.24013477 |
12 | MP0003252_abnormal_bile_duct | 3.07453876 |
13 | MP0003183_abnormal_peptide_metabolism | 3.00390309 |
14 | MP0003806_abnormal_nucleotide_metabolis | 2.95400840 |
15 | MP0000566_synostosis | 2.94114140 |
16 | MP0001664_abnormal_digestion | 2.80919341 |
17 | MP0001765_abnormal_ion_homeostasis | 2.68839956 |
18 | MP0005636_abnormal_mineral_homeostasis | 2.60443056 |
19 | MP0009379_abnormal_foot_pigmentation | 2.59560682 |
20 | MP0003866_abnormal_defecation | 2.40770264 |
21 | MP0002136_abnormal_kidney_physiology | 2.18022808 |
22 | MP0001756_abnormal_urination | 2.16898354 |
23 | MP0010155_abnormal_intestine_physiology | 2.15050828 |
24 | MP0001873_stomach_inflammation | 2.02914953 |
25 | MP0010352_gastrointestinal_tract_polyps | 2.00747215 |
26 | MP0000490_abnormal_crypts_of | 1.89349847 |
27 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.85603421 |
28 | MP0010329_abnormal_lipoprotein_level | 1.85527337 |
29 | MP0005058_abnormal_lysosome_morphology | 1.79410502 |
30 | MP0000477_abnormal_intestine_morphology | 1.79270938 |
31 | MP0003186_abnormal_redox_activity | 1.75626378 |
32 | MP0005319_abnormal_enzyme/_coenzyme | 1.74659452 |
33 | MP0001666_abnormal_nutrient_absorption | 1.72723993 |
34 | MP0003878_abnormal_ear_physiology | 1.61244521 |
35 | MP0005377_hearing/vestibular/ear_phenot | 1.61244521 |
36 | MP0001958_emphysema | 1.58808010 |
37 | MP0003191_abnormal_cellular_cholesterol | 1.46601741 |
38 | MP0002118_abnormal_lipid_homeostasis | 1.45491407 |
39 | MP0005083_abnormal_biliary_tract | 1.42751333 |
40 | MP0000678_abnormal_parathyroid_gland | 1.36142351 |
41 | MP0000537_abnormal_urethra_morphology | 1.35428178 |
42 | MP0005381_digestive/alimentary_phenotyp | 1.33115497 |
43 | MP0000609_abnormal_liver_physiology | 1.31544086 |
44 | MP0005084_abnormal_gallbladder_morpholo | 1.29065054 |
45 | MP0000538_abnormal_urinary_bladder | 1.26088196 |
46 | MP0001764_abnormal_homeostasis | 1.25832932 |
47 | MP0009840_abnormal_foam_cell | 1.25289533 |
48 | MP0010678_abnormal_skin_adnexa | 1.24066447 |
49 | MP0006036_abnormal_mitochondrial_physio | 1.22343067 |
50 | MP0005451_abnormal_body_composition | 1.22320459 |
51 | MP0000462_abnormal_digestive_system | 1.16817413 |
52 | MP0005409_darkened_coat_color | 1.16169483 |
53 | MP0003453_abnormal_keratinocyte_physiol | 1.14076611 |
54 | MP0002876_abnormal_thyroid_physiology | 1.13969772 |
55 | MP0000467_abnormal_esophagus_morphology | 1.12428921 |
56 | MP0005670_abnormal_white_adipose | 1.09777266 |
57 | MP0009780_abnormal_chondrocyte_physiolo | 1.07910747 |
58 | MP0005535_abnormal_body_temperature | 1.02173384 |
59 | MP0008961_abnormal_basal_metabolism | 1.00363677 |
60 | MP0001216_abnormal_epidermal_layer | 0.96409868 |
61 | MP0008872_abnormal_physiological_respon | 0.94470871 |
62 | MP0002928_abnormal_bile_duct | 0.94047108 |
63 | MP0009764_decreased_sensitivity_to | 0.93266077 |
64 | MP0000465_gastrointestinal_hemorrhage | 0.93114676 |
65 | MP0004885_abnormal_endolymph | 0.92488858 |
66 | MP0002168_other_aberrant_phenotype | 0.91140577 |
67 | MP0009642_abnormal_blood_homeostasis | 0.89631631 |
68 | MP0003300_gastrointestinal_ulcer | 0.88429722 |
69 | MP0004185_abnormal_adipocyte_glucose | 0.87719489 |
70 | MP0005367_renal/urinary_system_phenotyp | 0.86771313 |
71 | MP0000516_abnormal_urinary_system | 0.86771313 |
72 | MP0000598_abnormal_liver_morphology | 0.86415361 |
73 | MP0005666_abnormal_adipose_tissue | 0.83997139 |
74 | MP0000230_abnormal_systemic_arterial | 0.82228360 |
75 | MP0002135_abnormal_kidney_morphology | 0.80777892 |
76 | MP0008469_abnormal_protein_level | 0.79139338 |
77 | MP0005448_abnormal_energy_balance | 0.78678208 |
78 | MP0003315_abnormal_perineum_morphology | 0.78610796 |
79 | MP0003329_amyloid_beta_deposits | 0.77202746 |
80 | MP0005408_hypopigmentation | 0.73891033 |
81 | MP0001501_abnormal_sleep_pattern | 0.73318541 |
82 | MP0003705_abnormal_hypodermis_morpholog | 0.72996194 |
83 | MP0002396_abnormal_hematopoietic_system | 0.72370870 |
84 | MP0004147_increased_porphyrin_level | 0.71330814 |
85 | MP0003172_abnormal_lysosome_physiology | 0.71043142 |
86 | MP0002896_abnormal_bone_mineralization | 0.69194336 |
87 | MP0003638_abnormal_response/metabolism_ | 0.68787306 |
88 | MP0000604_amyloidosis | 0.67675837 |
89 | MP0005220_abnormal_exocrine_pancreas | 0.67421474 |
90 | MP0003693_abnormal_embryo_hatching | 0.67260225 |
91 | MP0002089_abnormal_postnatal_growth/wei | 0.66515876 |
92 | MP0002249_abnormal_larynx_morphology | 0.64141943 |
93 | MP0001485_abnormal_pinna_reflex | 0.63947101 |
94 | MP0003718_maternal_effect | 0.63612695 |
95 | MP0002078_abnormal_glucose_homeostasis | 0.63469226 |
96 | MP0001188_hyperpigmentation | 0.62741626 |
97 | MP0004264_abnormal_extraembryonic_tissu | 0.62339733 |
98 | MP0000470_abnormal_stomach_morphology | 0.62145296 |
99 | MP0005076_abnormal_cell_differentiation | 0.61994509 |
100 | MP0002796_impaired_skin_barrier | 0.60882129 |
101 | MP0005310_abnormal_salivary_gland | 0.60210976 |
102 | MP0005395_other_phenotype | 0.58312729 |
103 | MP0001661_extended_life_span | 0.57348992 |
104 | MP0000747_muscle_weakness | 0.56918488 |
105 | MP0010234_abnormal_vibrissa_follicle | 0.56087107 |
106 | MP0000377_abnormal_hair_follicle | 0.55301095 |
107 | MP0004947_skin_inflammation | 0.55062182 |
108 | MP0010771_integument_phenotype | 0.52334915 |
109 | MP0001849_ear_inflammation | 0.51902637 |
110 | MP0003045_fibrosis | 0.51332228 |
111 | MP0002166_altered_tumor_susceptibility | 0.50605353 |
112 | MP0006035_abnormal_mitochondrial_morpho | 0.49591911 |
113 | MP0002971_abnormal_brown_adipose | 0.49280894 |
114 | MP0009115_abnormal_fat_cell | 0.49147790 |
115 | MP0009763_increased_sensitivity_to | 0.48768379 |
116 | MP0002822_catalepsy | 0.48356495 |
117 | MP0003953_abnormal_hormone_level | 0.47680027 |
118 | MP0005257_abnormal_intraocular_pressure | 0.47654885 |
119 | MP0003868_abnormal_feces_composition | 0.47519681 |
120 | MP0009765_abnormal_xenobiotic_induced | 0.47228753 |
121 | MP0005376_homeostasis/metabolism_phenot | 0.46676802 |
122 | MP0002277_abnormal_respiratory_mucosa | 0.45109027 |
123 | MP0000371_diluted_coat_color | 0.43204605 |
124 | MP0003724_increased_susceptibility_to | 0.42740335 |
125 | MP0003690_abnormal_glial_cell | 0.41359991 |
126 | MP0000613_abnormal_salivary_gland | 0.40829477 |
127 | MP0003879_abnormal_hair_cell | 0.40804496 |
128 | MP0003075_altered_response_to | 0.40756143 |
129 | MP0009672_abnormal_birth_weight | 0.40512794 |
130 | MP0003283_abnormal_digestive_organ | 0.39012819 |
131 | MP0005167_abnormal_blood-brain_barrier | 0.38731408 |
132 | MP0005266_abnormal_metabolism | 0.38693621 |
133 | MP0005165_increased_susceptibility_to | 0.38426804 |
134 | MP0008874_decreased_physiological_sensi | 0.37292729 |
135 | MP0005647_abnormal_sex_gland | 0.37090192 |
136 | MP0005501_abnormal_skin_physiology | 0.36525677 |
137 | MP0003959_abnormal_lean_body | 0.35551916 |
138 | MP0005166_decreased_susceptibility_to | 0.33586089 |
139 | MP0001663_abnormal_digestive_system | 0.33026758 |
140 | MP0002069_abnormal_eating/drinking_beha | 0.32859149 |
141 | MP0002115_abnormal_skeleton_extremities | 0.32568658 |
142 | MP0003646_muscle_fatigue | 0.31934247 |
143 | MP0001845_abnormal_inflammatory_respons | 0.29404374 |
144 | MP0005334_abnormal_fat_pad | 0.29315502 |
145 | MP0005375_adipose_tissue_phenotype | 0.28897765 |
146 | MP0002837_dystrophic_cardiac_calcinosis | 0.27643240 |
147 | MP0002098_abnormal_vibrissa_morphology | 0.26452620 |
148 | MP0004782_abnormal_surfactant_physiolog | 0.26160786 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Gout (HP:0001997) | 6.61616576 |
2 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 5.61798865 |
3 | Increased circulating renin level (HP:0000848) | 5.29050953 |
4 | Decreased circulating renin level (HP:0003351) | 5.23297420 |
5 | Hyperglycinuria (HP:0003108) | 5.21020196 |
6 | Metabolic alkalosis (HP:0200114) | 5.17402630 |
7 | Proximal tubulopathy (HP:0000114) | 5.16629542 |
8 | Hypokalemic alkalosis (HP:0001949) | 5.09433892 |
9 | Polyuria (HP:0000103) | 4.98986790 |
10 | Ileus (HP:0002595) | 4.88507166 |
11 | Hyperactive renin-angiotensin system (HP:0000841) | 4.88153569 |
12 | Abnormal urine output (HP:0012590) | 4.76115955 |
13 | Abnormality of renal excretion (HP:0011036) | 4.61264172 |
14 | Increased purine levels (HP:0004368) | 4.60555605 |
15 | Hyperuricemia (HP:0002149) | 4.60555605 |
16 | Abnormality of purine metabolism (HP:0004352) | 4.55487495 |
17 | Hypomagnesemia (HP:0002917) | 4.53978841 |
18 | Abnormality of glycine metabolism (HP:0010895) | 4.51991168 |
19 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.51991168 |
20 | Generalized aminoaciduria (HP:0002909) | 4.51210890 |
21 | Abnormality of chloride homeostasis (HP:0011422) | 4.48125867 |
22 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 4.41286921 |
23 | Focal segmental glomerulosclerosis (HP:0000097) | 4.31227828 |
24 | Ketosis (HP:0001946) | 4.16843042 |
25 | Alkalosis (HP:0001948) | 4.06609429 |
26 | Right ventricular cardiomyopathy (HP:0011663) | 3.97535740 |
27 | Ketoacidosis (HP:0001993) | 3.87855550 |
28 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 3.85529568 |
29 | Abdominal distention (HP:0003270) | 3.82136365 |
30 | Abnormality of magnesium homeostasis (HP:0004921) | 3.82102241 |
31 | Abnormal drinking behavior (HP:0030082) | 3.79244907 |
32 | Polydipsia (HP:0001959) | 3.79244907 |
33 | Abnormality of nucleobase metabolism (HP:0010932) | 3.78007869 |
34 | Facial shape deformation (HP:0011334) | 3.77142071 |
35 | Potter facies (HP:0002009) | 3.77142071 |
36 | Abnormality of urine glucose concentration (HP:0011016) | 3.74151860 |
37 | Glycosuria (HP:0003076) | 3.74151860 |
38 | Chronic diarrhea (HP:0002028) | 3.72148686 |
39 | Abnormality of vitamin B metabolism (HP:0004340) | 3.71995342 |
40 | Delayed CNS myelination (HP:0002188) | 3.70102352 |
41 | Hyperglycinemia (HP:0002154) | 3.66151670 |
42 | Hypobetalipoproteinemia (HP:0003563) | 3.65632380 |
43 | Hyperammonemia (HP:0001987) | 3.62084030 |
44 | Glomerulosclerosis (HP:0000096) | 3.54943577 |
45 | Intrahepatic cholestasis (HP:0001406) | 3.54640146 |
46 | Flat acetabular roof (HP:0003180) | 3.53745784 |
47 | Hydroxyprolinuria (HP:0003080) | 3.53538462 |
48 | Abnormality of proline metabolism (HP:0010907) | 3.53538462 |
49 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 3.52795462 |
50 | Wide cranial sutures (HP:0010537) | 3.43841059 |
51 | Hypercalciuria (HP:0002150) | 3.40300553 |
52 | Abnormality of vitamin metabolism (HP:0100508) | 3.37890806 |
53 | Hemorrhage of the eye (HP:0011885) | 3.32944307 |
54 | Pigmentary retinal degeneration (HP:0001146) | 3.32111369 |
55 | Abnormality of renin-angiotensin system (HP:0000847) | 3.26863856 |
56 | Xanthomatosis (HP:0000991) | 3.25550687 |
57 | Renal salt wasting (HP:0000127) | 3.25044428 |
58 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 3.24098702 |
59 | Conjugated hyperbilirubinemia (HP:0002908) | 3.21985342 |
60 | Hyperphosphaturia (HP:0003109) | 3.21911834 |
61 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.18006865 |
62 | Vascular calcification (HP:0004934) | 3.16777594 |
63 | Renal tubular acidosis (HP:0001947) | 3.16247461 |
64 | Hyperaldosteronism (HP:0000859) | 3.15474968 |
65 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 3.07626844 |
66 | Hyponatremia (HP:0002902) | 3.06396358 |
67 | Hypotension (HP:0002615) | 3.04374655 |
68 | Abnormal urine phosphate concentration (HP:0012599) | 3.02719683 |
69 | Acanthocytosis (HP:0001927) | 2.98348854 |
70 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.97411152 |
71 | Dicarboxylic aciduria (HP:0003215) | 2.97411152 |
72 | Nephrolithiasis (HP:0000787) | 2.96352557 |
73 | Rickets (HP:0002748) | 2.92792573 |
74 | Tetany (HP:0001281) | 2.89211952 |
75 | Delayed epiphyseal ossification (HP:0002663) | 2.88056348 |
76 | Hypophosphatemia (HP:0002148) | 2.83486694 |
77 | Cardiovascular calcification (HP:0011915) | 2.83102801 |
78 | Pili torti (HP:0003777) | 2.82153755 |
79 | Malnutrition (HP:0004395) | 2.81635288 |
80 | Abnormality of small intestinal villus morphology (HP:0011472) | 2.79730804 |
81 | Villous atrophy (HP:0011473) | 2.79730804 |
82 | Metabolic acidosis (HP:0001942) | 2.73556041 |
83 | Abnormal enzyme/coenzyme activity (HP:0012379) | 2.72205774 |
84 | Congenital sensorineural hearing impairment (HP:0008527) | 2.61002068 |
85 | Lethargy (HP:0001254) | 2.60824645 |
86 | Vomiting (HP:0002013) | 2.60505482 |
87 | Nephrocalcinosis (HP:0000121) | 2.60337313 |
88 | Abnormality of alkaline phosphatase activity (HP:0004379) | 2.58894023 |
89 | Deep venous thrombosis (HP:0002625) | 2.55534273 |
90 | Abnormal hair laboratory examination (HP:0003328) | 2.52009498 |
91 | Hyperkalemia (HP:0002153) | 2.48013462 |
92 | Enlarged kidneys (HP:0000105) | 2.45485204 |
93 | Hypokalemia (HP:0002900) | 2.44695501 |
94 | Irritability (HP:0000737) | 2.42310116 |
95 | Confusion (HP:0001289) | 2.41776308 |
96 | Sensorimotor neuropathy (HP:0007141) | 2.40861082 |
97 | Abnormality of serum amino acid levels (HP:0003112) | 2.40404975 |
98 | Curly hair (HP:0002212) | 2.39937320 |
99 | Vacuolated lymphocytes (HP:0001922) | 2.39487437 |
100 | Hypoglycemic coma (HP:0001325) | 2.39121643 |
101 | Widely patent fontanelles and sutures (HP:0004492) | 2.37201512 |
102 | Methylmalonic aciduria (HP:0012120) | 2.37187642 |
103 | Subcapsular cataract (HP:0000523) | 2.34328619 |
104 | Steatorrhea (HP:0002570) | 2.33317969 |
105 | Metaphyseal cupping (HP:0003021) | 2.32876435 |
106 | Neonatal onset (HP:0003623) | 2.31135964 |
107 | Abnormal biliary tract morphology (HP:0012440) | 2.29830673 |
108 | Abnormal tarsal ossification (HP:0008369) | 2.29197463 |
109 | Elevated alkaline phosphatase (HP:0003155) | 2.25693587 |
110 | Hypolipoproteinemia (HP:0010981) | 2.24238829 |
111 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.23048617 |
112 | Tubular atrophy (HP:0000092) | 2.21336951 |
113 | Spastic diplegia (HP:0001264) | 2.13906735 |
114 | Dehydration (HP:0001944) | 2.11223726 |
115 | Abnormality of potassium homeostasis (HP:0011042) | 2.09737118 |
116 | Hepatocellular carcinoma (HP:0001402) | 2.09427650 |
117 | Nausea (HP:0002018) | 2.09347708 |
118 | Late onset (HP:0003584) | 2.09008518 |
119 | Posterior subcapsular cataract (HP:0007787) | 2.07815018 |
120 | Abnormality of sodium homeostasis (HP:0010931) | 2.06848779 |
121 | Lymphangioma (HP:0100764) | 2.05260906 |
122 | Renal tubular dysfunction (HP:0000124) | 2.01350849 |
123 | Woolly hair (HP:0002224) | 2.00375206 |
124 | Thin bony cortex (HP:0002753) | 1.99630725 |
125 | Hypophosphatemic rickets (HP:0004912) | 1.99296302 |
126 | Adrenal overactivity (HP:0002717) | 1.97260111 |
127 | Hyperparathyroidism (HP:0000843) | 1.96532204 |
128 | Abnormality of renal resorption (HP:0011038) | 1.95699187 |
129 | Hyperphosphatemia (HP:0002905) | 1.95063774 |
130 | Axonal loss (HP:0003447) | 1.94528491 |
131 | Abnormality of the costochondral junction (HP:0000919) | 1.92280610 |
132 | Fat malabsorption (HP:0002630) | 1.92089864 |
133 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.91956579 |
134 | Paraparesis (HP:0002385) | 1.90014851 |
135 | Joint hemorrhage (HP:0005261) | 1.89409323 |
136 | Enlarged epiphyses (HP:0010580) | 1.87493282 |
137 | Chronic bronchitis (HP:0004469) | 1.86459906 |
138 | Hyperventilation (HP:0002883) | 1.86033989 |
139 | Cerebral edema (HP:0002181) | 1.85636207 |
140 | Bilateral sensorineural hearing impairment (HP:0008619) | 1.85263876 |
141 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.83885427 |
142 | Tachypnea (HP:0002789) | 1.83218292 |
143 | Distal lower limb amyotrophy (HP:0008944) | 1.82157388 |
144 | Complement deficiency (HP:0004431) | 1.79660927 |
145 | Hyperbilirubinemia (HP:0002904) | 1.79248464 |
146 | Petechiae (HP:0000967) | 1.77060562 |
147 | Megaloblastic anemia (HP:0001889) | 1.76576076 |
148 | Neonatal short-limb short stature (HP:0008921) | 1.75036301 |
149 | Syncope (HP:0001279) | 1.74877103 |
150 | Palpitations (HP:0001962) | 1.73560008 |
151 | Hypoalbuminemia (HP:0003073) | 1.73283374 |
152 | Abnormal albumin level (HP:0012116) | 1.73283374 |
153 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 1.72862068 |
Rank | Gene Set | Z-score |
---|---|---|
1 | WNK4 | 7.92107294 |
2 | WNK3 | 6.98506567 |
3 | EPHA2 | 6.71039966 |
4 | OXSR1 | 5.90002987 |
5 | BCKDK | 5.42242432 |
6 | LMTK2 | 4.69347293 |
7 | ACVR1B | 4.23417574 |
8 | STK39 | 2.98768821 |
9 | EPHB2 | 2.67589796 |
10 | STK38L | 2.64034113 |
11 | FGFR4 | 2.48386105 |
12 | PRKG2 | 2.26214374 |
13 | PIK3CA | 2.16967382 |
14 | MAP3K10 | 2.12714020 |
15 | PDK3 | 2.10612352 |
16 | PDK4 | 2.10612352 |
17 | NEK1 | 2.05488259 |
18 | ERN1 | 1.90755009 |
19 | WNK1 | 1.78897928 |
20 | SGK494 | 1.69244621 |
21 | SGK223 | 1.69244621 |
22 | MST1R | 1.66223301 |
23 | STK24 | 1.48614842 |
24 | MAP3K12 | 1.45748847 |
25 | STK38 | 1.45076758 |
26 | EPHB1 | 1.44448850 |
27 | GRK6 | 1.32204775 |
28 | PDK2 | 1.31502574 |
29 | SIK1 | 1.09378643 |
30 | PINK1 | 1.03590677 |
31 | TRIB3 | 1.01660806 |
32 | GSK3A | 0.97420944 |
33 | MAPK11 | 0.96686012 |
34 | DYRK1B | 0.94110093 |
35 | ERBB4 | 0.93854304 |
36 | PTK6 | 0.93600733 |
37 | DDR2 | 0.91508777 |
38 | LRRK2 | 0.90580895 |
39 | MAP3K7 | 0.89049216 |
40 | ABL2 | 0.88692192 |
41 | RPS6KB2 | 0.81722793 |
42 | MAP2K2 | 0.81458275 |
43 | PTK2 | 0.79751850 |
44 | IRAK4 | 0.78565882 |
45 | TAOK1 | 0.77151751 |
46 | SGK3 | 0.76467692 |
47 | PHKG2 | 0.75320744 |
48 | PHKG1 | 0.75320744 |
49 | MST4 | 0.74870825 |
50 | MAP2K4 | 0.73723154 |
51 | CAMK2D | 0.73335630 |
52 | INSRR | 0.72849359 |
53 | TESK1 | 0.69131874 |
54 | PIK3CG | 0.64809486 |
55 | MAP2K6 | 0.64451186 |
56 | MATK | 0.64102372 |
57 | SGK2 | 0.63445330 |
58 | TIE1 | 0.63358093 |
59 | PDPK1 | 0.62316917 |
60 | MAP3K3 | 0.60141057 |
61 | TGFBR2 | 0.59588554 |
62 | PRKAA1 | 0.56322180 |
63 | MET | 0.54823729 |
64 | TNIK | 0.54137981 |
65 | PRKAA2 | 0.53565030 |
66 | PRKCZ | 0.53198992 |
67 | SGK1 | 0.52341380 |
68 | PAK3 | 0.50704932 |
69 | PAK4 | 0.50449605 |
70 | TESK2 | 0.50350240 |
71 | MAP3K14 | 0.50097323 |
72 | LATS1 | 0.49867422 |
73 | JAK2 | 0.48747919 |
74 | RPS6KA4 | 0.46622643 |
75 | RIPK1 | 0.46307972 |
76 | PKN2 | 0.45190110 |
77 | TYK2 | 0.44464431 |
78 | CDK8 | 0.43925932 |
79 | PDK1 | 0.42449928 |
80 | FER | 0.40581497 |
81 | FRK | 0.40343296 |
82 | MAP2K3 | 0.39465491 |
83 | PRKACG | 0.39453492 |
84 | MAP3K1 | 0.38324041 |
85 | EPHA4 | 0.37363798 |
86 | NTRK1 | 0.37301546 |
87 | MAP4K1 | 0.37023671 |
88 | PTK2B | 0.36548924 |
89 | FGFR3 | 0.36197872 |
90 | AKT3 | 0.36141251 |
91 | IRAK3 | 0.36128438 |
92 | CAMK2B | 0.35901853 |
93 | MAP3K11 | 0.35577853 |
94 | MAPK15 | 0.35426299 |
95 | CDC42BPA | 0.34716842 |
96 | MAPKAPK3 | 0.32491866 |
97 | DAPK2 | 0.31729315 |
98 | STK10 | 0.30079083 |
99 | IRAK2 | 0.29966308 |
100 | BRSK2 | 0.29906319 |
101 | NEK9 | 0.28390591 |
102 | MAPKAPK2 | 0.27943930 |
103 | CDK9 | 0.27789813 |
104 | MAPK12 | 0.27489037 |
105 | TAOK3 | 0.26775521 |
106 | CSK | 0.26366958 |
107 | PRPF4B | 0.26333142 |
108 | GRK1 | 0.26175555 |
109 | PRKCD | 0.25852801 |
110 | PRKCH | 0.25034698 |
111 | MAP3K2 | 0.24852726 |
112 | MAPK4 | 0.24838457 |
113 | KDR | 0.24726229 |
114 | PRKCE | 0.24511375 |
115 | SRC | 0.22870834 |
116 | MELK | 0.22861347 |
117 | BMX | 0.22288877 |
118 | IRAK1 | 0.22228962 |
119 | STK3 | 0.21319873 |
120 | TBK1 | 0.20583270 |
121 | PRKCI | 0.20270294 |
122 | ERBB2 | 0.20096374 |
123 | PRKCA | 0.19915355 |
124 | PRKCG | 0.19655265 |
125 | PRKCQ | 0.18537853 |
126 | CSF1R | 0.18330664 |
127 | PRKD2 | 0.18064897 |
128 | STK11 | 0.17703327 |
129 | ICK | 0.17064500 |
130 | CSNK1A1 | 0.17033924 |
131 | JAK1 | 0.15207168 |
132 | DAPK1 | 0.14559009 |
133 | MYLK | 0.14025673 |
134 | NME2 | 0.13371821 |
135 | PRKACA | 0.13365647 |
136 | AKT2 | 0.13239588 |
137 | NME1 | 0.12928404 |
138 | TRIM28 | 0.12177532 |
139 | ARAF | 0.11991127 |
140 | MAP2K1 | 0.11399018 |
141 | CAMK4 | 0.10516469 |
142 | GRK5 | 0.09787500 |
143 | CAMK2G | 0.09672595 |
144 | MTOR | 0.09564751 |
145 | IGF1R | 0.09554622 |
146 | KSR2 | 0.09360689 |
147 | EGFR | 0.09171187 |
148 | MINK1 | 0.07911306 |
149 | DMPK | 0.07810364 |
150 | ILK | 0.06750774 |
151 | FYN | 0.04963727 |
152 | AURKB | 0.04430524 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Butanoate metabolism_Homo sapiens_hsa00650 | 3.42071929 |
2 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 3.35783288 |
3 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 3.23032374 |
4 | * Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.07588096 |
5 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 3.00574115 |
6 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.96781691 |
7 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.88686793 |
8 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.82122005 |
9 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.77775998 |
10 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 2.75509001 |
11 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.62707264 |
12 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.62147226 |
13 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 2.58162648 |
14 | * Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.52140324 |
15 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.49800816 |
16 | Peroxisome_Homo sapiens_hsa04146 | 2.48654359 |
17 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.47609979 |
18 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.30837816 |
19 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.27402894 |
20 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.17651971 |
21 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.15961366 |
22 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.00998761 |
23 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.86317845 |
24 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.85960833 |
25 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.85082998 |
26 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.84608032 |
27 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.68553528 |
28 | Bile secretion_Homo sapiens_hsa04976 | 1.66314557 |
29 | Carbon metabolism_Homo sapiens_hsa01200 | 1.64595006 |
30 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.54330527 |
31 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.51544898 |
32 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.48342050 |
33 | Histidine metabolism_Homo sapiens_hsa00340 | 1.45506545 |
34 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.44707134 |
35 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.44370490 |
36 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.30799038 |
37 | * Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.30768077 |
38 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.27419287 |
39 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.26832928 |
40 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.24917902 |
41 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.24742490 |
42 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.14509662 |
43 | Lysine degradation_Homo sapiens_hsa00310 | 1.12804411 |
44 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.11295218 |
45 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.08348691 |
46 | * Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.07822193 |
47 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.07252800 |
48 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.06484987 |
49 | * Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.04375848 |
50 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.99176220 |
51 | * Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.97173437 |
52 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.94650314 |
53 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.94605420 |
54 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.93966602 |
55 | * Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.91591078 |
56 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.90931106 |
57 | * Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.84402719 |
58 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.84026606 |
59 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.83879316 |
60 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.82991124 |
61 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.81595499 |
62 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.73315815 |
63 | * Retinol metabolism_Homo sapiens_hsa00830 | 0.72373419 |
64 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.72180341 |
65 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.69551849 |
66 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.67475236 |
67 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.65454759 |
68 | Mineral absorption_Homo sapiens_hsa04978 | 0.64374454 |
69 | Other glycan degradation_Homo sapiens_hsa00511 | 0.62807833 |
70 | ABC transporters_Homo sapiens_hsa02010 | 0.58705123 |
71 | Sulfur relay system_Homo sapiens_hsa04122 | 0.56542016 |
72 | Renin secretion_Homo sapiens_hsa04924 | 0.54414136 |
73 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.53538935 |
74 | Tight junction_Homo sapiens_hsa04530 | 0.52523823 |
75 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.49698820 |
76 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.48824483 |
77 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.48366865 |
78 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.45678584 |
79 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.43848094 |
80 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.43376643 |
81 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.38181100 |
82 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.36813715 |
83 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.36693290 |
84 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.35714923 |
85 | Lysosome_Homo sapiens_hsa04142 | 0.32585034 |
86 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.32170397 |
87 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.30228456 |
88 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.27308665 |
89 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.25411604 |
90 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.25193111 |
91 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.23677981 |
92 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.22645745 |
93 | * Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.21053828 |
94 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.20463891 |
95 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.19958895 |
96 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.14981077 |
97 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.14355585 |
98 | Insulin resistance_Homo sapiens_hsa04931 | 0.14209790 |
99 | Hepatitis C_Homo sapiens_hsa05160 | 0.14165421 |
100 | Galactose metabolism_Homo sapiens_hsa00052 | 0.12656928 |
101 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.12082718 |
102 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.10448022 |
103 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.06274361 |
104 | Parkinsons disease_Homo sapiens_hsa05012 | 0.05085238 |
105 | Adherens junction_Homo sapiens_hsa04520 | 0.03188883 |
106 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.02016190 |
107 | Insulin secretion_Homo sapiens_hsa04911 | 0.01513504 |
108 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.00632435 |
109 | Thyroid cancer_Homo sapiens_hsa05216 | 0.00561734 |
110 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.00185143 |
111 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | -0.1582936 |
112 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | -0.1505066 |
113 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | -0.1362942 |
114 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | -0.1233518 |
115 | Prion diseases_Homo sapiens_hsa05020 | -0.1199148 |
116 | Amphetamine addiction_Homo sapiens_hsa05031 | -0.1101813 |
117 | Alzheimers disease_Homo sapiens_hsa05010 | -0.1092745 |
118 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | -0.1029909 |
119 | Serotonergic synapse_Homo sapiens_hsa04726 | -0.0956808 |
120 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | -0.0903799 |
121 | Choline metabolism in cancer_Homo sapiens_hsa05231 | -0.0825302 |
122 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.0813168 |
123 | Vibrio cholerae infection_Homo sapiens_hsa05110 | -0.0737530 |
124 | Asthma_Homo sapiens_hsa05310 | -0.0723287 |
125 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | -0.0585825 |
126 | Cocaine addiction_Homo sapiens_hsa05030 | -0.0316373 |
127 | Gastric acid secretion_Homo sapiens_hsa04971 | -0.0028496 |