ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	drug catabolic process (GO:0042737)	9.54733685
2	epoxygenase P450 pathway (GO:0019373)	9.35600611
3	omega-hydroxylase P450 pathway (GO:0097267)	9.07157810
4	complement activation, alternative pathway (GO:0006957)	7.71605170
5	regulation of fibrinolysis (GO:0051917)	7.68491582
6	glyoxylate metabolic process (GO:0046487)	7.60300681
7	negative regulation of fibrinolysis (GO:0051918)	7.42659281
8	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.42515895
9	L-phenylalanine catabolic process (GO:0006559)	7.42515895
10	regulation of protein activation cascade (GO:2000257)	7.15897860
11	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.88892304
12	L-phenylalanine metabolic process (GO:0006558)	6.88892304
13	* cellular glucuronidation (GO:0052695)	6.70659258
14	regulation of complement activation (GO:0030449)	6.68133522
15	drug metabolic process (GO:0017144)	6.65487922
16	urea metabolic process (GO:0019627)	6.61878894
17	* glucuronate metabolic process (GO:0019585)	6.39929819
18	* uronic acid metabolic process (GO:0006063)	6.39929819
19	ethanol oxidation (GO:0006069)	6.29396941
20	fibrinolysis (GO:0042730)	6.06423020
21	oxidative demethylation (GO:0070989)	6.04877526
22	bile acid biosynthetic process (GO:0006699)	6.02268664
23	nitrogen cycle metabolic process (GO:0071941)	6.00151186
24	peptidyl-glutamic acid carboxylation (GO:0017187)	5.90003253
25	protein carboxylation (GO:0018214)	5.90003253
26	negative regulation of sterol transport (GO:0032372)	5.57749184
27	negative regulation of cholesterol transport (GO:0032375)	5.57749184
28	bile acid metabolic process (GO:0008206)	5.55525446
29	urea cycle (GO:0000050)	5.53401844
30	aromatic amino acid family catabolic process (GO:0009074)	5.53219960
31	phenylpropanoid metabolic process (GO:0009698)	5.45422126
32	regulation of triglyceride catabolic process (GO:0010896)	5.42027361
33	blood coagulation, intrinsic pathway (GO:0007597)	5.39860203
34	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.36835722
35	serine family amino acid catabolic process (GO:0009071)	5.29340631
36	bile acid and bile salt transport (GO:0015721)	5.13139970
37	ethanol metabolic process (GO:0006067)	5.04815329
38	regulation of plasminogen activation (GO:0010755)	4.94370660
39	glycine metabolic process (GO:0006544)	4.86141811
40	protein activation cascade (GO:0072376)	4.78797424
41	imidazole-containing compound metabolic process (GO:0052803)	4.76348867
42	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.75790114
43	S-adenosylmethionine metabolic process (GO:0046500)	4.67866745
44	negative regulation of hemostasis (GO:1900047)	4.63599317
45	negative regulation of blood coagulation (GO:0030195)	4.63599317
46	acylglycerol homeostasis (GO:0055090)	4.51517208
47	triglyceride homeostasis (GO:0070328)	4.51517208
48	complement activation (GO:0006956)	4.51257646
49	alkaloid metabolic process (GO:0009820)	4.45171097
50	opsonization (GO:0008228)	4.43870953
51	intestinal cholesterol absorption (GO:0030299)	4.43271573
52	complement activation, classical pathway (GO:0006958)	4.41145722
53	acute-phase response (GO:0006953)	4.37900773
54	daunorubicin metabolic process (GO:0044597)	4.33395663
55	polyketide metabolic process (GO:0030638)	4.33395663
56	doxorubicin metabolic process (GO:0044598)	4.33395663
57	glutamate metabolic process (GO:0006536)	4.33350635
58	tyrosine metabolic process (GO:0006570)	4.32264918
59	phospholipid efflux (GO:0033700)	4.30253162
60	amino-acid betaine metabolic process (GO:0006577)	4.30221662
61	negative regulation of protein activation cascade (GO:2000258)	4.28676013
62	negative regulation of coagulation (GO:0050819)	4.23960166
63	regulation of humoral immune response (GO:0002920)	4.22182070
64	protein-lipid complex remodeling (GO:0034368)	4.21050024
65	macromolecular complex remodeling (GO:0034367)	4.21050024
66	plasma lipoprotein particle remodeling (GO:0034369)	4.21050024
67	high-density lipoprotein particle remodeling (GO:0034375)	4.20115181
68	cholesterol efflux (GO:0033344)	4.19822340
69	negative regulation of wound healing (GO:0061045)	4.17116188
70	positive regulation of lipoprotein lipase activity (GO:0051006)	4.16838117
71	positive regulation of triglyceride lipase activity (GO:0061365)	4.16838117
72	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.04657263
73	cellular ketone body metabolic process (GO:0046950)	4.02762129
74	fat-soluble vitamin biosynthetic process (GO:0042362)	3.98268107
75	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.94742849
76	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.94742849
77	cytolysis (GO:0019835)	3.92692574
78	serine family amino acid metabolic process (GO:0009069)	3.88503081
79	hormone catabolic process (GO:0042447)	3.87594502
80	alpha-amino acid catabolic process (GO:1901606)	3.85541912
81	aminoglycoside antibiotic metabolic process (GO:0030647)	3.85299745
82	tryptophan catabolic process (GO:0006569)	3.84956906
83	indole-containing compound catabolic process (GO:0042436)	3.84956906
84	indolalkylamine catabolic process (GO:0046218)	3.84956906
85	negative regulation of lipase activity (GO:0060192)	3.82843514
86	regulation of cholesterol esterification (GO:0010872)	3.79339008
87	positive regulation of blood coagulation (GO:0030194)	3.78723976
88	positive regulation of hemostasis (GO:1900048)	3.78723976
89	* flavonoid metabolic process (GO:0009812)	3.78277726
90	heme transport (GO:0015886)	3.76372088
91	reverse cholesterol transport (GO:0043691)	3.76162426
92	very-low-density lipoprotein particle assembly (GO:0034379)	3.70362301
93	arginine metabolic process (GO:0006525)	3.68361705
94	* xenobiotic metabolic process (GO:0006805)	3.61372957
95	aromatic amino acid family metabolic process (GO:0009072)	3.59777769
96	primary alcohol catabolic process (GO:0034310)	3.56590203
97	ketone body metabolic process (GO:1902224)	3.52861295
98	serine family amino acid biosynthetic process (GO:0009070)	3.52372119
99	positive regulation of coagulation (GO:0050820)	3.51925755
100	exogenous drug catabolic process (GO:0042738)	10.3950275

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	6.80054152
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.75317790
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.73403882
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.60498297
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.34334482
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.62461508
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.56239120
8	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	4.15593547
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.84639148
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.28742751
11	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.45185371
12	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.17601703
13	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.15633338
14	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.13030829
15	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.2874124
16	HTT_18923047_ChIP-ChIP_STHdh_Human	1.66056279
17	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.63263379
18	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.61712896
19	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.44025187
20	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.40474473
21	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.28071947
22	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.23857476
23	GATA4_25053715_ChIP-Seq_YYC3_Human	1.22692393
24	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.19132747
25	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.18726556
26	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.15506652
27	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.14097022
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.09143008
29	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.06759635
30	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.05600224
31	GATA6_25053715_ChIP-Seq_YYC3_Human	1.03519574
32	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.99196434
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.97964810
34	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.95936907
35	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.94695466
36	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.86030972
37	CBP_21632823_ChIP-Seq_H3396_Human	0.85165423
38	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.82968975
39	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.82583546
40	* PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.80432039
41	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.80275533
42	SOX2_20726797_ChIP-Seq_SW620_Human	0.79609640
43	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.77496305
44	BCAT_22108803_ChIP-Seq_LS180_Human	0.76643334
45	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.76581794
46	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.76452458
47	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.76044430
48	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.75401721
49	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.74399713
50	CEBPB_22108803_ChIP-Seq_LS180_Human	0.73423034
51	PHF8_20622853_ChIP-Seq_HELA_Human	0.71278292
52	* SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.70342130
53	LXR_22292898_ChIP-Seq_THP-1_Human	0.69504351
54	AR_20517297_ChIP-Seq_VCAP_Human	0.68883226
55	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.68875476
56	CLOCK_20551151_ChIP-Seq_293T_Human	0.68699099
57	GATA1_22025678_ChIP-Seq_K562_Human	0.68577572
58	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.67307991
59	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.67170180
60	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.66560863
61	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.66186143
62	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.66125157
63	IRF1_19129219_ChIP-ChIP_H3396_Human	0.64945117
64	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.64293053
65	SOX2_21211035_ChIP-Seq_LN229_Human	0.63728983
66	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.62357639
67	TP53_18474530_ChIP-ChIP_U2OS_Human	0.61901166
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.61665281
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.60725416
70	NFYA_21822215_ChIP-Seq_K562_Human	0.59849572
71	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.59810963
72	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.59108089
73	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.59048385
74	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.57150922
75	CDX2_22108803_ChIP-Seq_LS180_Human	0.55718787
76	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.55700559
77	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.55391179
78	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.55310517
79	RAC3_21632823_ChIP-Seq_H3396_Human	0.55060574
80	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.54877320
81	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.54574255
82	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.53462968
83	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.53451025
84	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.52337569
85	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.52337569
86	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.51892327
87	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.51586988
88	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.51509887
89	SPI1_20517297_ChIP-Seq_HL60_Human	0.51476554
90	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.51178851
91	SMC4_20622854_ChIP-Seq_HELA_Human	0.50047575
92	MYC_19915707_ChIP-ChIP_AK7_Human	0.49254135
93	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.49102686
94	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.49009570
95	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.48756336
96	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.48323266
97	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.46713497
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.46689435
99	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.46619107
100	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.46314273

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	9.73436121
2	MP0005085_abnormal_gallbladder_physiolo	6.54574955
3	MP0005365_abnormal_bile_salt	6.00457647
4	MP0005360_urolithiasis	5.91730705
5	MP0008875_abnormal_xenobiotic_pharmacok	5.89083114
6	MP0003195_calcinosis	4.66375478
7	MP0003252_abnormal_bile_duct	4.31469804
8	MP0002138_abnormal_hepatobiliary_system	3.81203036
9	MP0001666_abnormal_nutrient_absorption	3.62916259
10	MP0003868_abnormal_feces_composition	2.99724908
11	MP0010329_abnormal_lipoprotein_level	2.97812300
12	MP0005332_abnormal_amino_acid	2.46016947
13	MP0003191_abnormal_cellular_cholesterol	2.44565845
14	MP0009840_abnormal_foam_cell	2.30123750
15	MP0003806_abnormal_nucleotide_metabolis	2.21351369
16	MP0009697_abnormal_copulation	2.19979529
17	MP0000609_abnormal_liver_physiology	1.93727572
18	MP0002876_abnormal_thyroid_physiology	1.89700213
19	MP0005670_abnormal_white_adipose	1.79121045
20	MP0002118_abnormal_lipid_homeostasis	1.75825898
21	MP0004019_abnormal_vitamin_homeostasis	1.70770457
22	MP0010368_abnormal_lymphatic_system	1.62370236
23	MP0001764_abnormal_homeostasis	1.47592027
24	MP0005408_hypopigmentation	1.28481930
25	MP0009053_abnormal_anal_canal	1.21609746
26	MP0005319_abnormal_enzyme/_coenzyme	1.19677416
27	MP0009643_abnormal_urine_homeostasis	1.13774995
28	MP0005584_abnormal_enzyme/coenzyme_acti	1.10710767
29	MP0003656_abnormal_erythrocyte_physiolo	1.09647949
30	MP0001661_extended_life_span	1.08037056
31	MP0000598_abnormal_liver_morphology	1.06963211
32	MP0005451_abnormal_body_composition	1.03631143
33	MP0002132_abnormal_respiratory_system	1.01662116
34	MP0000604_amyloidosis	0.99086988
35	MP0009764_decreased_sensitivity_to	0.89913984
36	MP0009642_abnormal_blood_homeostasis	0.88809061
37	MP0009763_increased_sensitivity_to	0.86492598
38	MP0008469_abnormal_protein_level	0.85338655
39	MP0005636_abnormal_mineral_homeostasis	0.85188731
40	MP0003186_abnormal_redox_activity	0.84220594
41	MP0002971_abnormal_brown_adipose	0.80692169
42	MP0003879_abnormal_hair_cell	0.78417699
43	MP0005376_homeostasis/metabolism_phenot	0.78248596
44	MP0008872_abnormal_physiological_respon	0.78079644
45	MP0002282_abnormal_trachea_morphology	0.75830727
46	MP0001915_intracranial_hemorrhage	0.75554740
47	MP0005395_other_phenotype	0.72070784
48	MP0005464_abnormal_platelet_physiology	0.69000528
49	MP0003011_delayed_dark_adaptation	0.68242561
50	MP0005535_abnormal_body_temperature	0.67766337
51	MP0005023_abnormal_wound_healing	0.67249686
52	MP0002249_abnormal_larynx_morphology	0.66621841
53	MP0003690_abnormal_glial_cell	0.64006283
54	MP0005266_abnormal_metabolism	0.63083630
55	MP0002078_abnormal_glucose_homeostasis	0.61308943
56	MP0002168_other_aberrant_phenotype	0.56840100
57	MP0003638_abnormal_response/metabolism_	0.56154715
58	MP0000467_abnormal_esophagus_morphology	0.55817528
59	MP0005334_abnormal_fat_pad	0.53316609
60	MP0005187_abnormal_penis_morphology	0.52270230
61	MP0008874_decreased_physiological_sensi	0.51366009
62	MP0009765_abnormal_xenobiotic_induced	0.48888690
63	MP0003329_amyloid_beta_deposits	0.47984544
64	MP0002136_abnormal_kidney_physiology	0.46847681
65	MP0004782_abnormal_surfactant_physiolog	0.46144890
66	MP0009785_altered_susceptibility_to	0.42824682
67	MP0003718_maternal_effect	0.42641407
68	MP0005166_decreased_susceptibility_to	0.41556441
69	MP0005448_abnormal_energy_balance	0.40597532
70	MP0006036_abnormal_mitochondrial_physio	0.38958313
71	MP0000249_abnormal_blood_vessel	0.37908888
72	MP0005666_abnormal_adipose_tissue	0.37421229
73	MP0004264_abnormal_extraembryonic_tissu	0.37381590
74	MP0000566_synostosis	0.33968939
75	MP0005058_abnormal_lysosome_morphology	0.33932127
76	MP0003705_abnormal_hypodermis_morpholog	0.33778931
77	MP0005164_abnormal_response_to	0.32246758
78	MP0003953_abnormal_hormone_level	0.32039307
79	MP0004130_abnormal_muscle_cell	0.31937315
80	MP0009115_abnormal_fat_cell	0.31868895
81	MP0002332_abnormal_exercise_endurance	0.29802343
82	MP0003075_altered_response_to	0.28042257
83	MP0004883_abnormal_blood_vessel	0.27712488
84	MP0001756_abnormal_urination	0.27497113
85	MP0001986_abnormal_taste_sensitivity	0.27317433
86	MP0001851_eye_inflammation	0.27247273
87	MP0002089_abnormal_postnatal_growth/wei	0.26106213
88	MP0008873_increased_physiological_sensi	0.23898537
89	MP0010155_abnormal_intestine_physiology	0.23785852
90	MP0001845_abnormal_inflammatory_respons	0.23529069
91	MP0001881_abnormal_mammary_gland	0.22549087
92	MP0000639_abnormal_adrenal_gland	0.19839855
93	MP0005377_hearing/vestibular/ear_phenot	0.19583028
94	MP0003878_abnormal_ear_physiology	0.19583028
95	MP0005197_abnormal_uvea_morphology	0.19241360
96	MP0002970_abnormal_white_adipose	0.19044618
97	MP0002135_abnormal_kidney_morphology	0.17430044
98	MP0005409_darkened_coat_color	0.17417966
99	MP0005647_abnormal_sex_gland	0.17363890
100	MP0003959_abnormal_lean_body	0.17063300

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of monocarboxylic acid metabolism (HP:0010996)	9.92111330
2	Deep venous thrombosis (HP:0002625)	9.15649823
3	Complement deficiency (HP:0004431)	9.06015052
4	Hypobetalipoproteinemia (HP:0003563)	8.46316907
5	Prolonged partial thromboplastin time (HP:0003645)	8.42060199
6	Abnormality of aromatic amino acid family metabolism (HP:0004338)	8.09055671
7	Abnormality of complement system (HP:0005339)	7.38821506
8	Conjugated hyperbilirubinemia (HP:0002908)	7.16051827
9	Systemic lupus erythematosus (HP:0002725)	5.95636828
10	Intrahepatic cholestasis (HP:0001406)	5.92854952
11	Joint hemorrhage (HP:0005261)	5.75368607
12	Hyperlipoproteinemia (HP:0010980)	5.51307595
13	Xanthomatosis (HP:0000991)	4.97385643
14	Abnormality of the common coagulation pathway (HP:0010990)	4.94844952
15	Spontaneous abortion (HP:0005268)	4.89429928
16	Glomerulonephritis (HP:0000099)	4.89194571
17	Hypolipoproteinemia (HP:0010981)	4.84968591
18	Abnormality of pyrimidine metabolism (HP:0004353)	4.58038760
19	Fat malabsorption (HP:0002630)	4.32642610
20	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.11925339
21	Recurrent gram-negative bacterial infections (HP:0005420)	4.07571370
22	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.86408676
23	Abnormality of the intrinsic pathway (HP:0010989)	3.82361286
24	Nephritis (HP:0000123)	3.78002613
25	Abnormality of methionine metabolism (HP:0010901)	3.58674921
26	Steatorrhea (HP:0002570)	3.35954722
27	Hyperammonemia (HP:0001987)	3.30892346
28	Hypoalphalipoproteinemia (HP:0003233)	3.29634833
29	Gingival bleeding (HP:0000225)	3.25451123
30	Hypercholesterolemia (HP:0003124)	3.22240932
31	Generalized aminoaciduria (HP:0002909)	3.04868417
32	Hyperglycinemia (HP:0002154)	3.02773663
33	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.98697405
34	Rickets (HP:0002748)	2.97473577
35	Hyperbilirubinemia (HP:0002904)	2.97397291
36	Delayed CNS myelination (HP:0002188)	2.95865099
37	Hemorrhage of the eye (HP:0011885)	2.90805598
38	Osteomalacia (HP:0002749)	2.87722687
39	Abnormality of glycine metabolism (HP:0010895)	2.79168473
40	Abnormality of serine family amino acid metabolism (HP:0010894)	2.79168473
41	Vascular calcification (HP:0004934)	2.76072383
42	Epidermoid cyst (HP:0200040)	2.68506590
43	Abnormality of nucleobase metabolism (HP:0010932)	2.66132846
44	Thrombophlebitis (HP:0004418)	2.64929048
45	Mitral stenosis (HP:0001718)	2.64231137
46	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.61941084
47	Abnormality of vitamin metabolism (HP:0100508)	2.54247936
48	Hyperglycinuria (HP:0003108)	2.52818430
49	Hepatocellular carcinoma (HP:0001402)	2.44504817
50	Cardiovascular calcification (HP:0011915)	2.42402954
51	Abnormality of serum amino acid levels (HP:0003112)	2.41233337
52	Neonatal hypoglycemia (HP:0001998)	2.40037634
53	Hyperphosphaturia (HP:0003109)	2.36370867
54	Glycosuria (HP:0003076)	2.24764868
55	Abnormality of urine glucose concentration (HP:0011016)	2.24764868
56	Fair hair (HP:0002286)	2.23324269
57	Elevated alkaline phosphatase (HP:0003155)	2.18675524
58	Metabolic acidosis (HP:0001942)	2.16872609
59	Purpura (HP:0000979)	2.12885013
60	Joint swelling (HP:0001386)	2.10432407
61	Menorrhagia (HP:0000132)	2.07885126
62	Poikilocytosis (HP:0004447)	2.05937884
63	Abnormal enzyme/coenzyme activity (HP:0012379)	2.04638859
64	Pulmonary embolism (HP:0002204)	2.03389153
65	Increased mean platelet volume (HP:0011877)	2.02191022
66	Abnormality of proline metabolism (HP:0010907)	2.01506764
67	Hydroxyprolinuria (HP:0003080)	2.01506764
68	Abnormality of alkaline phosphatase activity (HP:0004379)	2.00446704
69	Abnormal urine phosphate concentration (HP:0012599)	1.99663379
70	Cholelithiasis (HP:0001081)	1.94909878
71	Reduced antithrombin III activity (HP:0001976)	1.93514846
72	Hypophosphatemic rickets (HP:0004912)	1.93412486
73	Cerebral palsy (HP:0100021)	1.89572492
74	Ketosis (HP:0001946)	1.87963529
75	Abnormal gallbladder morphology (HP:0012437)	1.87779626
76	Myocardial infarction (HP:0001658)	1.86972478
77	Irritability (HP:0000737)	1.82577450
78	Abnormal platelet volume (HP:0011876)	1.81755296
79	Abnormality of the Achilles tendon (HP:0005109)	1.80272992
80	Increased serum ferritin (HP:0003281)	1.80073564
81	Abnormality of purine metabolism (HP:0004352)	1.78175969
82	Hypoglycemic coma (HP:0001325)	1.77985355
83	Abnormality of iron homeostasis (HP:0011031)	1.77370268
84	Enlarged kidneys (HP:0000105)	1.76007373
85	Neonatal onset (HP:0003623)	1.73537891
86	Abnormality of transition element cation homeostasis (HP:0011030)	1.73115188
87	Reticulocytosis (HP:0001923)	1.73098609
88	Gout (HP:0001997)	1.70281268
89	Acanthocytosis (HP:0001927)	1.67206555
90	Epistaxis (HP:0000421)	1.66634363
91	Skin nodule (HP:0200036)	1.66598424
92	Proximal tubulopathy (HP:0000114)	1.63422488
93	Bifid scrotum (HP:0000048)	1.62663545
94	Abnormal delivery (HP:0001787)	1.60508402
95	Amyloidosis (HP:0011034)	1.59540403
96	Arthropathy (HP:0003040)	1.59287687
97	Abnormal platelet function (HP:0011869)	1.58315474
98	Impaired platelet aggregation (HP:0003540)	1.58315474
99	Megaloblastic anemia (HP:0001889)	1.57930181
100	Abnormality of fatty-acid metabolism (HP:0004359)	1.56767335

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	5.47083579
2	MST1R	3.64033519
3	RIPK1	3.29601648
4	PDK2	3.23164218
5	FGFR4	3.17440059
6	SIK1	2.75359495
7	PIK3CG	2.73892539
8	TRIB3	2.42536875
9	TYK2	2.38989468
10	IRAK3	2.37901427
11	MAP3K3	2.31505432
12	ACVR1B	2.21842982
13	MAP3K12	2.12641548
14	PRKACG	1.91023457
15	MAP3K2	1.89400619
16	PIK3CA	1.85638388
17	PBK	1.85340265
18	MAPK11	1.81894590
19	EPHA2	1.71617549
20	PRKAA2	1.65301761
21	EPHA3	1.55642296
22	PDPK1	1.55447077
23	MET	1.51665353
24	NTRK3	1.47057509
25	MAP2K4	1.43293062
26	TAOK3	1.41154369
27	FGFR3	1.37352127
28	TESK2	1.31809915
29	BCKDK	1.30710065
30	MYLK	1.28603794
31	NEK9	1.28233590
32	ABL2	1.23652615
33	EPHB1	1.21129588
34	FER	1.19172994
35	IGF1R	1.13188667
36	SMG1	1.12942855
37	ERBB4	1.08278570
38	NLK	1.06427128
39	TBK1	1.04281023
40	JAK1	1.03879545
41	PDK1	1.01357178
42	ERBB2	1.01334593
43	PRPF4B	0.90315294
44	PRKG2	0.86992532
45	SCYL2	0.85608507
46	PRKCZ	0.85331611
47	MAP3K1	0.84798967
48	PRKCG	0.84198632
49	AKT3	0.80286269
50	MAP3K6	0.80252227
51	PTK6	0.77839564
52	ICK	0.76030298
53	ARAF	0.75639665
54	PRKAA1	0.69360692
55	PDGFRA	0.69325108
56	RET	0.66255561
57	EPHA4	0.65002538
58	CAMK2G	0.64953298
59	PRKG1	0.64356502
60	MAP2K6	0.61753346
61	CSF1R	0.60902308
62	LMTK2	0.60670045
63	PRKACA	0.60383403
64	MAP3K9	0.57948932
65	CDK9	0.55607342
66	PRKCA	0.55430345
67	KSR2	0.54549252
68	STK38	0.51985019
69	CAMKK2	0.50876606
70	CDK6	0.50097348
71	KDR	0.50006743
72	PTK2	0.49876484
73	PRKACB	0.49490927
74	SGK3	0.49490306
75	PRKCB	0.49356523
76	MAP2K2	0.49198595
77	TNK2	0.46568990
78	JAK2	0.45989044
79	CSNK1E	0.45920999
80	MAP3K11	0.45237574
81	CSNK1D	0.45007718
82	SRC	0.44385390
83	MAP3K5	0.44268602
84	PINK1	0.43210311
85	MAP3K13	0.40564672
86	IRAK1	0.40519814
87	DYRK1B	0.39526395
88	PRKCE	0.38018370
89	INSRR	0.36918968
90	RPS6KA3	0.36860271
91	BRSK2	0.35927836
92	PKN2	0.34443320
93	LATS2	0.33628033
94	MAPKAPK3	0.33530253
95	RPS6KB2	0.33499725
96	CSNK1A1	0.31394914
97	TAOK2	0.31235307
98	CAMK2B	0.31062506
99	GSK3A	0.30917581
100	CSNK2A1	0.30334907

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.59501938
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.99578222
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.85478271
4	* Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.50858213
5	* Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.49850982
6	Complement and coagulation cascades_Homo sapiens_hsa04610	3.48846945
7	* Retinol metabolism_Homo sapiens_hsa00830	3.38327136
8	* Chemical carcinogenesis_Homo sapiens_hsa05204	2.98438990
9	* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.94702733
10	* Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.77165126
11	* Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.67992705
12	* Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.61045664
13	Arginine biosynthesis_Homo sapiens_hsa00220	2.59073719
14	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.49509502
15	Fatty acid degradation_Homo sapiens_hsa00071	2.40856859
16	Phenylalanine metabolism_Homo sapiens_hsa00360	2.35379638
17	Tyrosine metabolism_Homo sapiens_hsa00350	2.16231879
18	Butanoate metabolism_Homo sapiens_hsa00650	2.08330904
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.96499963
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.96329279
21	Histidine metabolism_Homo sapiens_hsa00340	1.92475628
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.84843597
23	* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.82514712
24	Bile secretion_Homo sapiens_hsa04976	1.74464228
25	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.64130169
26	* Starch and sucrose metabolism_Homo sapiens_hsa00500	1.61011356
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.57630782
28	PPAR signaling pathway_Homo sapiens_hsa03320	1.47779979
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.40305207
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.38114434
31	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.37456159
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.25332044
33	Peroxisome_Homo sapiens_hsa04146	1.23438848
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.22003980
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.20952096
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.17537980
37	Fat digestion and absorption_Homo sapiens_hsa04975	1.13403954
38	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.13282714
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.05764336
40	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.05128009
41	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.04089669
42	Prion diseases_Homo sapiens_hsa05020	1.03160465
43	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.03092525
44	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.96463411
45	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.93331551
46	Carbon metabolism_Homo sapiens_hsa01200	0.92139947
47	Propanoate metabolism_Homo sapiens_hsa00640	0.89576861
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.88529231
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84591536
50	Fatty acid metabolism_Homo sapiens_hsa01212	0.82947030
51	ABC transporters_Homo sapiens_hsa02010	0.82094148
52	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.81063114
53	One carbon pool by folate_Homo sapiens_hsa00670	0.73838262
54	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.60006793
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52745954
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47524856
57	Lysine degradation_Homo sapiens_hsa00310	0.43689348
58	* Metabolic pathways_Homo sapiens_hsa01100	0.42841061
59	Sulfur metabolism_Homo sapiens_hsa00920	0.38657340
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35069189
61	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.34100071
62	Galactose metabolism_Homo sapiens_hsa00052	0.32320806
63	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.30885906
64	Sulfur relay system_Homo sapiens_hsa04122	0.30071696
65	Pentose phosphate pathway_Homo sapiens_hsa00030	0.29446862
66	Fatty acid elongation_Homo sapiens_hsa00062	0.25548324
67	Glutathione metabolism_Homo sapiens_hsa00480	0.22540315
68	Insulin resistance_Homo sapiens_hsa04931	0.21420860
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.20788035
70	Pertussis_Homo sapiens_hsa05133	0.20355725
71	Renin-angiotensin system_Homo sapiens_hsa04614	0.16611170
72	Mineral absorption_Homo sapiens_hsa04978	0.16430712
73	Glucagon signaling pathway_Homo sapiens_hsa04922	0.15791058
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.15208516
75	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.08769588
76	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.05722914
77	Folate biosynthesis_Homo sapiens_hsa00790	0.04312709
78	Selenocompound metabolism_Homo sapiens_hsa00450	0.02479641
79	Nitrogen metabolism_Homo sapiens_hsa00910	0.02332627
80	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.02302348
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.01798829
82	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.2648013
83	Circadian rhythm_Homo sapiens_hsa04710	-0.2575673
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	-0.2396811
85	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.2308986
86	N-Glycan biosynthesis_Homo sapiens_hsa00510	-0.2156759
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.1836622
88	Protein digestion and absorption_Homo sapiens_hsa04974	-0.1695445
89	Ether lipid metabolism_Homo sapiens_hsa00565	-0.1682204
90	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1514798
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.1319895
92	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.1204300
93	African trypanosomiasis_Homo sapiens_hsa05143	-0.1088780
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.0700416
95	Amoebiasis_Homo sapiens_hsa05146	-0.0574635
96	Serotonergic synapse_Homo sapiens_hsa04726	-0.0508695
97	Steroid biosynthesis_Homo sapiens_hsa00100	-0.0491276
98	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0162997
99	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.0080258
100	Other glycan degradation_Homo sapiens_hsa00511	-0.0004883

UGT1A3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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