ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	drug catabolic process (GO:0042737)	9.61886705
2	epoxygenase P450 pathway (GO:0019373)	8.65352007
3	omega-hydroxylase P450 pathway (GO:0097267)	8.41924253
4	regulation of fibrinolysis (GO:0051917)	8.33195476
5	negative regulation of fibrinolysis (GO:0051918)	8.13244437
6	glyoxylate metabolic process (GO:0046487)	8.02332819
7	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.96638599
8	L-phenylalanine catabolic process (GO:0006559)	7.96638599
9	complement activation, alternative pathway (GO:0006957)	7.77568056
10	regulation of protein activation cascade (GO:2000257)	7.36423588
11	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.32644378
12	L-phenylalanine metabolic process (GO:0006558)	7.32644378
13	urea metabolic process (GO:0019627)	7.08873341
14	regulation of complement activation (GO:0030449)	6.85003015
15	fibrinolysis (GO:0042730)	6.72470070
16	drug metabolic process (GO:0017144)	6.45450694
17	nitrogen cycle metabolic process (GO:0071941)	6.44816200
18	protein carboxylation (GO:0018214)	6.37747836
19	peptidyl-glutamic acid carboxylation (GO:0017187)	6.37747836
20	oxidative demethylation (GO:0070989)	6.25422296
21	bile acid biosynthetic process (GO:0006699)	6.23798534
22	ethanol oxidation (GO:0006069)	6.16605467
23	* cellular glucuronidation (GO:0052695)	6.08238200
24	urea cycle (GO:0000050)	5.94047815
25	blood coagulation, intrinsic pathway (GO:0007597)	5.88468671
26	aromatic amino acid family catabolic process (GO:0009074)	5.84611418
27	* uronic acid metabolic process (GO:0006063)	5.77450301
28	* glucuronate metabolic process (GO:0019585)	5.77450301
29	serine family amino acid catabolic process (GO:0009071)	5.72977595
30	regulation of triglyceride catabolic process (GO:0010896)	5.71637239
31	phenylpropanoid metabolic process (GO:0009698)	5.67437646
32	negative regulation of cholesterol transport (GO:0032375)	5.62224106
33	negative regulation of sterol transport (GO:0032372)	5.62224106
34	bile acid metabolic process (GO:0008206)	5.58456436
35	regulation of plasminogen activation (GO:0010755)	5.23613713
36	glycine metabolic process (GO:0006544)	5.18087447
37	bile acid and bile salt transport (GO:0015721)	5.10141730
38	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.99032756
39	ethanol metabolic process (GO:0006067)	4.97714433
40	negative regulation of hemostasis (GO:1900047)	4.92033274
41	negative regulation of blood coagulation (GO:0030195)	4.92033274
42	protein activation cascade (GO:0072376)	4.86027950
43	S-adenosylmethionine metabolic process (GO:0046500)	4.79644732
44	acylglycerol homeostasis (GO:0055090)	4.69171193
45	triglyceride homeostasis (GO:0070328)	4.69171193
46	tyrosine metabolic process (GO:0006570)	4.67335172
47	alkaloid metabolic process (GO:0009820)	4.64303461
48	amino-acid betaine metabolic process (GO:0006577)	4.60464881
49	complement activation (GO:0006956)	4.55030307
50	acute-phase response (GO:0006953)	4.53653347
51	negative regulation of coagulation (GO:0050819)	4.47105133
52	complement activation, classical pathway (GO:0006958)	4.46972128
53	negative regulation of wound healing (GO:0061045)	4.43825839
54	positive regulation of lipoprotein lipase activity (GO:0051006)	4.40860928
55	positive regulation of triglyceride lipase activity (GO:0061365)	4.40860928
56	imidazole-containing compound metabolic process (GO:0052803)	4.38704303
57	phospholipid efflux (GO:0033700)	4.36196239
58	regulation of humoral immune response (GO:0002920)	4.34257781
59	negative regulation of protein activation cascade (GO:2000258)	4.31749396
60	flavonoid metabolic process (GO:0009812)	4.25827126
61	hormone catabolic process (GO:0042447)	4.22973955
62	positive regulation of blood coagulation (GO:0030194)	4.16709401
63	positive regulation of hemostasis (GO:1900048)	4.16709401
64	doxorubicin metabolic process (GO:0044598)	4.13647896
65	daunorubicin metabolic process (GO:0044597)	4.13647896
66	polyketide metabolic process (GO:0030638)	4.13647896
67	serine family amino acid metabolic process (GO:0009069)	4.12655757
68	plasma lipoprotein particle remodeling (GO:0034369)	4.10043477
69	protein-lipid complex remodeling (GO:0034368)	4.10043477
70	macromolecular complex remodeling (GO:0034367)	4.10043477
71	arginine metabolic process (GO:0006525)	4.08339389
72	opsonization (GO:0008228)	4.01260663
73	negative regulation of lipase activity (GO:0060192)	3.97075900
74	tryptophan catabolic process (GO:0006569)	3.96142813
75	indole-containing compound catabolic process (GO:0042436)	3.96142813
76	indolalkylamine catabolic process (GO:0046218)	3.96142813
77	cholesterol efflux (GO:0033344)	3.94830660
78	heme transport (GO:0015886)	3.94566573
79	fat-soluble vitamin biosynthetic process (GO:0042362)	3.93248424
80	high-density lipoprotein particle remodeling (GO:0034375)	3.89842694
81	cytolysis (GO:0019835)	3.89228527
82	alpha-amino acid catabolic process (GO:1901606)	3.88896499
83	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.87417659
84	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.87417659
85	intestinal cholesterol absorption (GO:0030299)	3.86356765
86	positive regulation of coagulation (GO:0050820)	3.84918247
87	glutamate metabolic process (GO:0006536)	3.82670437
88	aromatic amino acid family metabolic process (GO:0009072)	3.80070539
89	regulation of cholesterol esterification (GO:0010872)	3.75488637
90	response to mercury ion (GO:0046689)	3.75234087
91	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.71770022
92	aminoglycoside antibiotic metabolic process (GO:0030647)	3.67115167
93	steroid catabolic process (GO:0006706)	3.65180157
94	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.63219523
95	* xenobiotic metabolic process (GO:0006805)	3.59276185
96	negative regulation of complement activation (GO:0045916)	3.55230818
97	serine family amino acid biosynthetic process (GO:0009070)	3.51534390
98	reverse cholesterol transport (GO:0043691)	3.49331296
99	cellular ketone body metabolic process (GO:0046950)	3.48299730
100	exogenous drug catabolic process (GO:0042738)	10.2522183

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.13834167
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.99084738
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.97121511
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.73863615
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.35167664
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.85456739
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.66774391
8	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	4.40055396
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	4.01842247
10	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.19159677
11	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.11109462
12	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.10342052
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.02516659
14	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.01560149
15	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.4644890
16	HTT_18923047_ChIP-ChIP_STHdh_Human	1.80357895
17	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.55831771
18	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.55409518
19	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.54679715
20	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.26878553
21	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.16048741
22	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.15886850
23	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.13933879
24	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.10160102
25	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.07688962
26	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.06532219
27	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.05651836
28	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.02458989
29	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.96930714
30	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92262246
31	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.89910535
32	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.89423759
33	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.86150448
34	GATA4_25053715_ChIP-Seq_YYC3_Human	0.84917422
35	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.84576781
36	CBP_21632823_ChIP-Seq_H3396_Human	0.81843710
37	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.79487723
38	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.78795214
39	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.78327812
40	PHF8_20622853_ChIP-Seq_HELA_Human	0.78026347
41	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.77544213
42	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.76535094
43	CEBPB_22108803_ChIP-Seq_LS180_Human	0.75406300
44	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.75198537
45	AR_20517297_ChIP-Seq_VCAP_Human	0.75044878
46	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.74676708
47	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.74292359
48	SOX2_21211035_ChIP-Seq_LN229_Human	0.73745260
49	GATA1_22025678_ChIP-Seq_K562_Human	0.73173182
50	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.73072016
51	IRF1_19129219_ChIP-ChIP_H3396_Human	0.71722938
52	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.71629023
53	BCAT_22108803_ChIP-Seq_LS180_Human	0.70079378
54	NFYA_21822215_ChIP-Seq_K562_Human	0.69867897
55	GATA6_25053715_ChIP-Seq_YYC3_Human	0.67916479
56	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.67623806
57	LXR_22292898_ChIP-Seq_THP-1_Human	0.67031047
58	TP53_18474530_ChIP-ChIP_U2OS_Human	0.65995775
59	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.64968032
60	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.64925351
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.63970599
62	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.62611123
63	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.62534969
64	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.62252215
65	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.59464742
66	RAC3_21632823_ChIP-Seq_H3396_Human	0.59252090
67	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.58728653
68	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.58211938
69	P53_21459846_ChIP-Seq_SAOS-2_Human	0.57688606
70	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.57388544
71	SOX2_20726797_ChIP-Seq_SW620_Human	0.56127063
72	SPI1_20517297_ChIP-Seq_HL60_Human	0.54633211
73	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.54428244
74	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.54245593
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.53379593
76	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.53235302
77	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.52578606
78	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.52435433
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.52174112
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.51976242
81	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.51701363
82	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.51089232
83	ERG_20517297_ChIP-Seq_VCAP_Human	0.51049672
84	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.51042708
85	ETV1_20927104_ChIP-Seq_GIST48_Human	0.50962206
86	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.50781512
87	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.50754996
88	CLOCK_20551151_ChIP-Seq_293T_Human	0.50605551
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.50190706
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.50168500
91	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.50091596
92	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.50091596
93	ER_23166858_ChIP-Seq_MCF-7_Human	0.48388709
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.47393918
95	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.47175565
96	SMC4_20622854_ChIP-Seq_HELA_Human	0.47094117
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.46852524
98	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.46210052
99	CTCF_20526341_ChIP-Seq_ESCs_Human	0.46165118
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.46084640

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	9.93712601
2	MP0005085_abnormal_gallbladder_physiolo	6.47229666
3	MP0005360_urolithiasis	6.06678371
4	MP0005365_abnormal_bile_salt	6.01203020
5	MP0008875_abnormal_xenobiotic_pharmacok	5.72000303
6	MP0003195_calcinosis	4.96577236
7	MP0002138_abnormal_hepatobiliary_system	4.50207869
8	MP0003252_abnormal_bile_duct	4.24544523
9	MP0003868_abnormal_feces_composition	3.62299493
10	MP0001666_abnormal_nutrient_absorption	3.39320398
11	MP0009697_abnormal_copulation	2.90890212
12	MP0010329_abnormal_lipoprotein_level	2.72134270
13	MP0003806_abnormal_nucleotide_metabolis	2.34215895
14	MP0009840_abnormal_foam_cell	2.31951516
15	MP0005332_abnormal_amino_acid	2.31611839
16	MP0003191_abnormal_cellular_cholesterol	2.16064399
17	MP0002876_abnormal_thyroid_physiology	1.95726081
18	MP0000609_abnormal_liver_physiology	1.86058279
19	MP0002118_abnormal_lipid_homeostasis	1.67503875
20	MP0001764_abnormal_homeostasis	1.59736631
21	MP0010368_abnormal_lymphatic_system	1.48175316
22	MP0004019_abnormal_vitamin_homeostasis	1.33548622
23	MP0009053_abnormal_anal_canal	1.18715564
24	MP0005319_abnormal_enzyme/_coenzyme	1.17202736
25	MP0005408_hypopigmentation	1.14692112
26	MP0005670_abnormal_white_adipose	1.09350526
27	MP0001661_extended_life_span	1.03736683
28	MP0000598_abnormal_liver_morphology	1.03621855
29	MP0005584_abnormal_enzyme/coenzyme_acti	1.03349484
30	MP0002132_abnormal_respiratory_system	0.97998211
31	MP0009643_abnormal_urine_homeostasis	0.96244016
32	MP0003656_abnormal_erythrocyte_physiolo	0.95033750
33	MP0005451_abnormal_body_composition	0.93219696
34	MP0003186_abnormal_redox_activity	0.87393512
35	MP0009764_decreased_sensitivity_to	0.86928192
36	MP0001915_intracranial_hemorrhage	0.86044545
37	MP0009763_increased_sensitivity_to	0.85549421
38	MP0000604_amyloidosis	0.83935141
39	MP0005187_abnormal_penis_morphology	0.82570662
40	MP0009642_abnormal_blood_homeostasis	0.81888881
41	MP0005376_homeostasis/metabolism_phenot	0.79659454
42	MP0008469_abnormal_protein_level	0.79118959
43	MP0002971_abnormal_brown_adipose	0.78859560
44	MP0005395_other_phenotype	0.71002480
45	MP0005636_abnormal_mineral_homeostasis	0.70410346
46	MP0003879_abnormal_hair_cell	0.68596695
47	MP0003011_delayed_dark_adaptation	0.68268217
48	MP0002282_abnormal_trachea_morphology	0.66097846
49	MP0005535_abnormal_body_temperature	0.64874887
50	MP0005464_abnormal_platelet_physiology	0.64032516
51	MP0003690_abnormal_glial_cell	0.62599412
52	MP0008872_abnormal_physiological_respon	0.62481751
53	MP0002168_other_aberrant_phenotype	0.61036046
54	MP0003638_abnormal_response/metabolism_	0.59207483
55	MP0008874_decreased_physiological_sensi	0.58406169
56	MP0005266_abnormal_metabolism	0.56925992
57	MP0002249_abnormal_larynx_morphology	0.54856512
58	MP0002078_abnormal_glucose_homeostasis	0.53427895
59	MP0005023_abnormal_wound_healing	0.51407447
60	MP0005334_abnormal_fat_pad	0.48828576
61	MP0009785_altered_susceptibility_to	0.45392766
62	MP0006036_abnormal_mitochondrial_physio	0.44995776
63	MP0005058_abnormal_lysosome_morphology	0.41475955
64	MP0000249_abnormal_blood_vessel	0.40779219
65	MP0009765_abnormal_xenobiotic_induced	0.39874196
66	MP0004130_abnormal_muscle_cell	0.39484864
67	MP0005166_decreased_susceptibility_to	0.38295807
68	MP0005164_abnormal_response_to	0.35981379
69	MP0003075_altered_response_to	0.33915949
70	MP0004883_abnormal_blood_vessel	0.33339077
71	MP0000467_abnormal_esophagus_morphology	0.32503565
72	MP0005448_abnormal_energy_balance	0.31755009
73	MP0002136_abnormal_kidney_physiology	0.31603094
74	MP0004782_abnormal_surfactant_physiolog	0.29636681
75	MP0003718_maternal_effect	0.29537975
76	MP0008873_increased_physiological_sensi	0.27502913
77	MP0002332_abnormal_exercise_endurance	0.26262475
78	MP0003329_amyloid_beta_deposits	0.25140100
79	MP0001851_eye_inflammation	0.24955094
80	MP0005647_abnormal_sex_gland	0.24798674
81	MP0003705_abnormal_hypodermis_morpholog	0.24573145
82	MP0003959_abnormal_lean_body	0.24552276
83	MP0005197_abnormal_uvea_morphology	0.23267364
84	MP0001845_abnormal_inflammatory_respons	0.23240407
85	MP0003953_abnormal_hormone_level	0.23234649
86	MP0009115_abnormal_fat_cell	0.22799956
87	MP0005220_abnormal_exocrine_pancreas	0.20346128
88	MP0002090_abnormal_vision	0.20004414
89	MP0002928_abnormal_bile_duct	0.19510748
90	MP0002970_abnormal_white_adipose	0.18941217
91	MP0005083_abnormal_biliary_tract	0.18925602
92	MP0001756_abnormal_urination	0.18556293
93	MP0005084_abnormal_gallbladder_morpholo	0.18272906
94	MP0000920_abnormal_myelination	0.16394123
95	MP0000566_synostosis	0.16221469
96	MP0005666_abnormal_adipose_tissue	0.15903494
97	MP0002089_abnormal_postnatal_growth/wei	0.15894355
98	MP0002128_abnormal_blood_circulation	0.15576198
99	MP0003632_abnormal_nervous_system	0.14984784
100	MP0001881_abnormal_mammary_gland	0.14567602

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Complement deficiency (HP:0004431)	9.02533914
2	Prolonged partial thromboplastin time (HP:0003645)	8.93254136
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	8.40165301
4	Hypobetalipoproteinemia (HP:0003563)	8.04803550
5	Abnormality of complement system (HP:0005339)	7.33905184
6	Conjugated hyperbilirubinemia (HP:0002908)	6.95105649
7	Systemic lupus erythematosus (HP:0002725)	6.12414981
8	Joint hemorrhage (HP:0005261)	6.07915265
9	Hyperlipoproteinemia (HP:0010980)	5.92066324
10	Intrahepatic cholestasis (HP:0001406)	5.56848607
11	Glomerulonephritis (HP:0000099)	5.01170511
12	Abnormality of pyrimidine metabolism (HP:0004353)	4.97573974
13	Xanthomatosis (HP:0000991)	4.82623692
14	Abnormality of the common coagulation pathway (HP:0010990)	4.70999886
15	Hypolipoproteinemia (HP:0010981)	4.61668565
16	Spontaneous abortion (HP:0005268)	4.24284694
17	Recurrent gram-negative bacterial infections (HP:0005420)	4.20741361
18	Abnormality of the intrinsic pathway (HP:0010989)	3.99290769
19	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.96386574
20	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.79162768
21	Nephritis (HP:0000123)	3.76297946
22	Fat malabsorption (HP:0002630)	3.68528270
23	Hypoalphalipoproteinemia (HP:0003233)	3.34100291
24	Hyperglycinemia (HP:0002154)	3.32104192
25	Hyperammonemia (HP:0001987)	3.31196822
26	Abnormality of methionine metabolism (HP:0010901)	3.21660466
27	Generalized aminoaciduria (HP:0002909)	3.12253611
28	Gingival bleeding (HP:0000225)	3.03779988
29	Rickets (HP:0002748)	2.99758260
30	Steatorrhea (HP:0002570)	2.95825798
31	Vascular calcification (HP:0004934)	2.90596879
32	Delayed CNS myelination (HP:0002188)	2.90382776
33	Mitral stenosis (HP:0001718)	2.89157148
34	Hemorrhage of the eye (HP:0011885)	2.86985028
35	Abnormality of serine family amino acid metabolism (HP:0010894)	2.84236487
36	Abnormality of glycine metabolism (HP:0010895)	2.84236487
37	Hypercholesterolemia (HP:0003124)	2.82150044
38	Abnormality of nucleobase metabolism (HP:0010932)	2.71946355
39	Hyperbilirubinemia (HP:0002904)	2.68029827
40	Osteomalacia (HP:0002749)	2.67918164
41	Reduced antithrombin III activity (HP:0001976)	2.67715297
42	Abnormality of serum amino acid levels (HP:0003112)	2.65651029
43	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.59426480
44	Hyperglycinuria (HP:0003108)	2.57836230
45	Cardiovascular calcification (HP:0011915)	2.57763738
46	Epidermoid cyst (HP:0200040)	2.55186542
47	Thrombophlebitis (HP:0004418)	2.50614926
48	Purpura (HP:0000979)	2.49168435
49	Hepatocellular carcinoma (HP:0001402)	2.40648762
50	Pulmonary embolism (HP:0002204)	2.38901762
51	Neonatal hypoglycemia (HP:0001998)	2.37850128
52	Menorrhagia (HP:0000132)	2.34888276
53	Fair hair (HP:0002286)	2.32883389
54	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.30294247
55	Cholelithiasis (HP:0001081)	2.19278139
56	Cholecystitis (HP:0001082)	2.18730322
57	Abnormal gallbladder physiology (HP:0012438)	2.18730322
58	Metabolic acidosis (HP:0001942)	2.17982243
59	Hyperphosphaturia (HP:0003109)	2.13705882
60	Abnormality of vitamin metabolism (HP:0100508)	2.13093305
61	Abnormality of the Achilles tendon (HP:0005109)	2.12461440
62	Arthropathy (HP:0003040)	2.11940338
63	Abnormal gallbladder morphology (HP:0012437)	2.07316835
64	Elevated alkaline phosphatase (HP:0003155)	2.04265640
65	Irritability (HP:0000737)	2.03428254
66	Abnormality of monocarboxylic acid metabolism (HP:0010996)	10.6807575
67	Deep venous thrombosis (HP:0002625)	10.2063009
68	Glycosuria (HP:0003076)	1.99196827
69	Abnormality of urine glucose concentration (HP:0011016)	1.99196827
70	Myocardial infarction (HP:0001658)	1.96820749
71	Hypochromic microcytic anemia (HP:0004840)	1.94909599
72	Abnormal enzyme/coenzyme activity (HP:0012379)	1.90373327
73	Bifid scrotum (HP:0000048)	1.89349433
74	Ketosis (HP:0001946)	1.87559012
75	Joint swelling (HP:0001386)	1.85640998
76	Abnormality of alkaline phosphatase activity (HP:0004379)	1.84768763
77	Increased mean platelet volume (HP:0011877)	1.82250992
78	Increased serum ferritin (HP:0003281)	1.81498652
79	Hypophosphatemic rickets (HP:0004912)	1.81010731
80	Abnormality of iron homeostasis (HP:0011031)	1.80624396
81	Gangrene (HP:0100758)	1.75998185
82	Hydroxyprolinuria (HP:0003080)	1.73722902
83	Abnormality of proline metabolism (HP:0010907)	1.73722902
84	Atrioventricular block (HP:0001678)	1.72229895
85	Abnormal urine phosphate concentration (HP:0012599)	1.71980341
86	Poikilocytosis (HP:0004447)	1.71520461
87	Abnormality of purine metabolism (HP:0004352)	1.68533696
88	Bile duct proliferation (HP:0001408)	1.66865388
89	Abnormal biliary tract physiology (HP:0012439)	1.66865388
90	Abnormal platelet volume (HP:0011876)	1.64837402
91	Abnormality of transition element cation homeostasis (HP:0011030)	1.63501286
92	Epistaxis (HP:0000421)	1.63286890
93	Cerebral palsy (HP:0100021)	1.62328340
94	Lethargy (HP:0001254)	1.60905171
95	Generalized hypopigmentation of hair (HP:0011358)	1.60487463
96	Impaired platelet aggregation (HP:0003540)	1.55855680
97	Abnormal platelet function (HP:0011869)	1.55855680
98	Alkalosis (HP:0001948)	1.55533646
99	Abnormality of the gallbladder (HP:0005264)	1.52728012
100	Skin nodule (HP:0200036)	1.51850473

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	5.51001804
2	PIK3CG	3.78219419
3	FGFR4	3.62225211
4	RIPK1	3.58539664
5	TRIB3	2.77780631
6	TYK2	2.68543624
7	SIK1	2.49652958
8	BCKDK	2.41949944
9	PRKACG	2.29940576
10	PRPF4B	2.26590111
11	PIK3CA	2.22469000
12	MAP3K3	1.99260005
13	EPHA3	1.95421265
14	MST1R	1.87008484
15	MAP3K12	1.82351076
16	MAP2K4	1.81072338
17	TBK1	1.80092134
18	NTRK3	1.74762670
19	IRAK3	1.73743351
20	ABL2	1.71245672
21	PRKAA2	1.69548728
22	MAPK11	1.62335796
23	NEK9	1.52399162
24	PRKCG	1.51456009
25	MYLK	1.46150106
26	FGFR3	1.37402248
27	IGF1R	1.36361482
28	TAOK3	1.34313426
29	JAK1	1.32889818
30	PDPK1	1.25858315
31	MAP3K2	1.13627432
32	PINK1	1.12209900
33	EPHA4	1.09485768
34	TNK2	1.09211819
35	NLK	1.06713319
36	ERBB2	1.05276905
37	PRKCZ	1.03213460
38	PRKG1	0.97892260
39	JAK2	0.97559765
40	MAP3K1	0.97497051
41	SCYL2	0.93705366
42	TAOK2	0.91731151
43	EPHB1	0.91514732
44	FER	0.90521221
45	MAP3K11	0.85944485
46	PRKACA	0.84854178
47	PDK1	0.82676444
48	CAMKK2	0.78584290
49	CDK6	0.78162151
50	PKN2	0.77813666
51	PRKAA1	0.76944504
52	ZAP70	0.74888630
53	RET	0.72865014
54	CSF1R	0.72637542
55	ERBB4	0.71951820
56	MAP3K6	0.69688631
57	ARAF	0.69613190
58	MAP2K3	0.68654511
59	CSNK1D	0.67364684
60	PRKCB	0.66883599
61	MAP3K5	0.64268571
62	KSR2	0.63272388
63	PRKCA	0.63021529
64	PDK2	0.62898903
65	ICK	0.62160628
66	STK38	0.60746904
67	PTK6	0.59457945
68	MET	0.57920898
69	RPS6KA3	0.55725171
70	MAPK4	0.55379509
71	KDR	0.54775865
72	CAMK2G	0.54684818
73	STK16	0.54382765
74	MAPK7	0.53983606
75	INSRR	0.53548935
76	DYRK1B	0.53071408
77	MAPKAPK3	0.52649943
78	MAPK12	0.52565511
79	TGFBR2	0.52361850
80	SGK1	0.52195424
81	GSK3A	0.50905879
82	SRC	0.46106165
83	TIE1	0.45186434
84	PRKACB	0.44306043
85	CSNK1E	0.40579130
86	EIF2AK1	0.39941483
87	CAMKK1	0.39134981
88	SGK3	0.38346682
89	MAP3K13	0.38167743
90	PIM2	0.37230115
91	CSNK2A1	0.36525200
92	CDK4	0.36420850
93	WNK3	0.35759343
94	MAP2K2	0.34405752
95	MTOR	0.34249301
96	DAPK2	0.33251677
97	CAMK1D	0.32773197
98	IKBKE	0.31576385
99	CSNK1A1	0.31217695
100	CSNK2A2	0.31163609

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.69788777
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.24283965
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.13866004
4	Complement and coagulation cascades_Homo sapiens_hsa04610	3.74346035
5	* Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.38714834
6	* Retinol metabolism_Homo sapiens_hsa00830	3.36968939
7	* Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.30059203
8	* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.89578138
9	* Chemical carcinogenesis_Homo sapiens_hsa05204	2.89139076
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.74757134
11	* Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.62890525
12	* Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.55432989
13	Arginine biosynthesis_Homo sapiens_hsa00220	2.53341410
14	* Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.52904095
15	Phenylalanine metabolism_Homo sapiens_hsa00360	2.47528170
16	Fatty acid degradation_Homo sapiens_hsa00071	2.34457938
17	Tyrosine metabolism_Homo sapiens_hsa00350	2.23474841
18	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.17703960
19	Butanoate metabolism_Homo sapiens_hsa00650	2.05687669
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89825874
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.87771927
22	Bile secretion_Homo sapiens_hsa04976	1.87623852
23	Histidine metabolism_Homo sapiens_hsa00340	1.83145742
24	* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.61713525
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51792457
26	* Starch and sucrose metabolism_Homo sapiens_hsa00500	1.41893523
27	PPAR signaling pathway_Homo sapiens_hsa03320	1.41558270
28	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.38783442
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37586798
30	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.37360326
31	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.35716754
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.34167448
33	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.32873681
34	Peroxisome_Homo sapiens_hsa04146	1.32146985
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.24648674
36	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.18700779
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.15581616
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15004262
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.13187747
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.07468994
41	Prion diseases_Homo sapiens_hsa05020	1.05940168
42	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.96761084
43	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.94740199
44	Arginine and proline metabolism_Homo sapiens_hsa00330	0.93786784
45	Carbon metabolism_Homo sapiens_hsa01200	0.87522495
46	Propanoate metabolism_Homo sapiens_hsa00640	0.84096665
47	Fat digestion and absorption_Homo sapiens_hsa04975	0.81355307
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.78552376
49	Fatty acid metabolism_Homo sapiens_hsa01212	0.77078860
50	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.76551427
51	One carbon pool by folate_Homo sapiens_hsa00670	0.75940614
52	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.75361249
53	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.75055640
54	ABC transporters_Homo sapiens_hsa02010	0.75042568
55	Sulfur metabolism_Homo sapiens_hsa00920	0.57979899
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53212334
57	Sulfur relay system_Homo sapiens_hsa04122	0.52410057
58	Lysine degradation_Homo sapiens_hsa00310	0.49257522
59	* Metabolic pathways_Homo sapiens_hsa01100	0.42272011
60	Pertussis_Homo sapiens_hsa05133	0.29181957
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.27173771
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.26001072
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25691366
64	Fatty acid elongation_Homo sapiens_hsa00062	0.25338737
65	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.23721664
66	Pentose phosphate pathway_Homo sapiens_hsa00030	0.23606861
67	Insulin resistance_Homo sapiens_hsa04931	0.19940894
68	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.12623908
69	Glucagon signaling pathway_Homo sapiens_hsa04922	0.10887620
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.10855772
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.07843995
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.07253565
73	Glutathione metabolism_Homo sapiens_hsa00480	0.06749804
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.06092623
75	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.05839420
76	Folate biosynthesis_Homo sapiens_hsa00790	0.03798047
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.03669286
78	Galactose metabolism_Homo sapiens_hsa00052	0.01908504
79	Other glycan degradation_Homo sapiens_hsa00511	0.00977316
80	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.2767432
81	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.2743844
82	Ether lipid metabolism_Homo sapiens_hsa00565	-0.2633945
83	Circadian rhythm_Homo sapiens_hsa04710	-0.2568918
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	-0.2544508
85	N-Glycan biosynthesis_Homo sapiens_hsa00510	-0.2411449
86	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.2368492
87	Nitrogen metabolism_Homo sapiens_hsa00910	-0.2143716
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.2005467
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.1747960
90	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1662108
91	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.1649631
92	African trypanosomiasis_Homo sapiens_hsa05143	-0.1107432
93	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.1058753
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.1035043
95	Amoebiasis_Homo sapiens_hsa05146	-0.0528880
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	-0.0490012
97	Mineral absorption_Homo sapiens_hsa04978	-0.0448154
98	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0222518
99	Serotonergic synapse_Homo sapiens_hsa04726	-0.0027969
100	Renin-angiotensin system_Homo sapiens_hsa04614	-0.0018705

UGT1A4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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