UGT1A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug catabolic process (GO:0042737)9.61886705
2epoxygenase P450 pathway (GO:0019373)8.65352007
3omega-hydroxylase P450 pathway (GO:0097267)8.41924253
4regulation of fibrinolysis (GO:0051917)8.33195476
5negative regulation of fibrinolysis (GO:0051918)8.13244437
6glyoxylate metabolic process (GO:0046487)8.02332819
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.96638599
8L-phenylalanine catabolic process (GO:0006559)7.96638599
9complement activation, alternative pathway (GO:0006957)7.77568056
10regulation of protein activation cascade (GO:2000257)7.36423588
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.32644378
12L-phenylalanine metabolic process (GO:0006558)7.32644378
13urea metabolic process (GO:0019627)7.08873341
14regulation of complement activation (GO:0030449)6.85003015
15fibrinolysis (GO:0042730)6.72470070
16drug metabolic process (GO:0017144)6.45450694
17nitrogen cycle metabolic process (GO:0071941)6.44816200
18protein carboxylation (GO:0018214)6.37747836
19peptidyl-glutamic acid carboxylation (GO:0017187)6.37747836
20oxidative demethylation (GO:0070989)6.25422296
21bile acid biosynthetic process (GO:0006699)6.23798534
22ethanol oxidation (GO:0006069)6.16605467
23* cellular glucuronidation (GO:0052695)6.08238200
24urea cycle (GO:0000050)5.94047815
25blood coagulation, intrinsic pathway (GO:0007597)5.88468671
26aromatic amino acid family catabolic process (GO:0009074)5.84611418
27* uronic acid metabolic process (GO:0006063)5.77450301
28* glucuronate metabolic process (GO:0019585)5.77450301
29serine family amino acid catabolic process (GO:0009071)5.72977595
30regulation of triglyceride catabolic process (GO:0010896)5.71637239
31phenylpropanoid metabolic process (GO:0009698)5.67437646
32negative regulation of cholesterol transport (GO:0032375)5.62224106
33negative regulation of sterol transport (GO:0032372)5.62224106
34bile acid metabolic process (GO:0008206)5.58456436
35regulation of plasminogen activation (GO:0010755)5.23613713
36glycine metabolic process (GO:0006544)5.18087447
37bile acid and bile salt transport (GO:0015721)5.10141730
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.99032756
39ethanol metabolic process (GO:0006067)4.97714433
40negative regulation of hemostasis (GO:1900047)4.92033274
41negative regulation of blood coagulation (GO:0030195)4.92033274
42protein activation cascade (GO:0072376)4.86027950
43S-adenosylmethionine metabolic process (GO:0046500)4.79644732
44acylglycerol homeostasis (GO:0055090)4.69171193
45triglyceride homeostasis (GO:0070328)4.69171193
46tyrosine metabolic process (GO:0006570)4.67335172
47alkaloid metabolic process (GO:0009820)4.64303461
48amino-acid betaine metabolic process (GO:0006577)4.60464881
49complement activation (GO:0006956)4.55030307
50acute-phase response (GO:0006953)4.53653347
51negative regulation of coagulation (GO:0050819)4.47105133
52complement activation, classical pathway (GO:0006958)4.46972128
53negative regulation of wound healing (GO:0061045)4.43825839
54positive regulation of lipoprotein lipase activity (GO:0051006)4.40860928
55positive regulation of triglyceride lipase activity (GO:0061365)4.40860928
56imidazole-containing compound metabolic process (GO:0052803)4.38704303
57phospholipid efflux (GO:0033700)4.36196239
58regulation of humoral immune response (GO:0002920)4.34257781
59negative regulation of protein activation cascade (GO:2000258)4.31749396
60flavonoid metabolic process (GO:0009812)4.25827126
61hormone catabolic process (GO:0042447)4.22973955
62positive regulation of blood coagulation (GO:0030194)4.16709401
63positive regulation of hemostasis (GO:1900048)4.16709401
64doxorubicin metabolic process (GO:0044598)4.13647896
65daunorubicin metabolic process (GO:0044597)4.13647896
66polyketide metabolic process (GO:0030638)4.13647896
67serine family amino acid metabolic process (GO:0009069)4.12655757
68plasma lipoprotein particle remodeling (GO:0034369)4.10043477
69protein-lipid complex remodeling (GO:0034368)4.10043477
70macromolecular complex remodeling (GO:0034367)4.10043477
71arginine metabolic process (GO:0006525)4.08339389
72opsonization (GO:0008228)4.01260663
73negative regulation of lipase activity (GO:0060192)3.97075900
74tryptophan catabolic process (GO:0006569)3.96142813
75indole-containing compound catabolic process (GO:0042436)3.96142813
76indolalkylamine catabolic process (GO:0046218)3.96142813
77cholesterol efflux (GO:0033344)3.94830660
78heme transport (GO:0015886)3.94566573
79fat-soluble vitamin biosynthetic process (GO:0042362)3.93248424
80high-density lipoprotein particle remodeling (GO:0034375)3.89842694
81cytolysis (GO:0019835)3.89228527
82alpha-amino acid catabolic process (GO:1901606)3.88896499
83killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.87417659
84disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.87417659
85intestinal cholesterol absorption (GO:0030299)3.86356765
86positive regulation of coagulation (GO:0050820)3.84918247
87glutamate metabolic process (GO:0006536)3.82670437
88aromatic amino acid family metabolic process (GO:0009072)3.80070539
89regulation of cholesterol esterification (GO:0010872)3.75488637
90response to mercury ion (GO:0046689)3.75234087
91positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.71770022
92aminoglycoside antibiotic metabolic process (GO:0030647)3.67115167
93steroid catabolic process (GO:0006706)3.65180157
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.63219523
95* xenobiotic metabolic process (GO:0006805)3.59276185
96negative regulation of complement activation (GO:0045916)3.55230818
97serine family amino acid biosynthetic process (GO:0009070)3.51534390
98reverse cholesterol transport (GO:0043691)3.49331296
99cellular ketone body metabolic process (GO:0046950)3.48299730
100exogenous drug catabolic process (GO:0042738)10.2522183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.13834167
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.99084738
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.97121511
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.73863615
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.35167664
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.85456739
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.66774391
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.40055396
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.01842247
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.19159677
11HNF4A_19822575_ChIP-Seq_HepG2_Human2.11109462
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.10342052
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02516659
14FOXA2_19822575_ChIP-Seq_HepG2_Human2.01560149
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4644890
16HTT_18923047_ChIP-ChIP_STHdh_Human1.80357895
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55831771
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55409518
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.54679715
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26878553
21AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16048741
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.15886850
23BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13933879
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10160102
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07688962
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06532219
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05651836
28RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02458989
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96930714
30PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92262246
31IRF8_22096565_ChIP-ChIP_GC-B_Human0.89910535
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89423759
33HNFA_21074721_ChIP-Seq_CACO-2_Human0.86150448
34GATA4_25053715_ChIP-Seq_YYC3_Human0.84917422
35CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84576781
36CBP_21632823_ChIP-Seq_H3396_Human0.81843710
37CDX2_20551321_ChIP-Seq_CACO-2_Human0.79487723
38FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78795214
39ESR2_21235772_ChIP-Seq_MCF-7_Human0.78327812
40PHF8_20622853_ChIP-Seq_HELA_Human0.78026347
41NFE2_27457419_Chip-Seq_LIVER_Mouse0.77544213
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76535094
43CEBPB_22108803_ChIP-Seq_LS180_Human0.75406300
44KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75198537
45AR_20517297_ChIP-Seq_VCAP_Human0.75044878
46SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74676708
47GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.74292359
48SOX2_21211035_ChIP-Seq_LN229_Human0.73745260
49GATA1_22025678_ChIP-Seq_K562_Human0.73173182
50FOXA1_25552417_ChIP-Seq_VCAP_Human0.73072016
51IRF1_19129219_ChIP-ChIP_H3396_Human0.71722938
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.71629023
53BCAT_22108803_ChIP-Seq_LS180_Human0.70079378
54NFYA_21822215_ChIP-Seq_K562_Human0.69867897
55GATA6_25053715_ChIP-Seq_YYC3_Human0.67916479
56GATA6_21074721_ChIP-Seq_CACO-2_Human0.67623806
57LXR_22292898_ChIP-Seq_THP-1_Human0.67031047
58TP53_18474530_ChIP-ChIP_U2OS_Human0.65995775
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64968032
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.64925351
61EZH2_27294783_Chip-Seq_NPCs_Mouse0.63970599
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62611123
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62534969
64SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62252215
65SALL4_18804426_ChIP-ChIP_XEN_Mouse0.59464742
66RAC3_21632823_ChIP-Seq_H3396_Human0.59252090
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.58728653
68CBX2_22325352_ChIP-Seq_293T-Rex_Human0.58211938
69P53_21459846_ChIP-Seq_SAOS-2_Human0.57688606
70PIAS1_25552417_ChIP-Seq_VCAP_Human0.57388544
71SOX2_20726797_ChIP-Seq_SW620_Human0.56127063
72SPI1_20517297_ChIP-Seq_HL60_Human0.54633211
73SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.54428244
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54245593
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.53379593
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53235302
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52578606
78SRY_22984422_ChIP-ChIP_TESTIS_Rat0.52435433
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.52174112
80ETV2_25802403_ChIP-Seq_MESCs_Mouse0.51976242
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.51701363
82PCGF2_27294783_Chip-Seq_NPCs_Mouse0.51089232
83ERG_20517297_ChIP-Seq_VCAP_Human0.51049672
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.51042708
85ETV1_20927104_ChIP-Seq_GIST48_Human0.50962206
86RARG_19884340_ChIP-ChIP_MEFs_Mouse0.50781512
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.50754996
88CLOCK_20551151_ChIP-Seq_293T_Human0.50605551
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.50190706
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.50168500
91NRF2_20460467_ChIP-Seq_MEFs_Mouse0.50091596
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.50091596
93ER_23166858_ChIP-Seq_MCF-7_Human0.48388709
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.47393918
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47175565
96SMC4_20622854_ChIP-Seq_HELA_Human0.47094117
97TAF2_19829295_ChIP-Seq_ESCs_Human0.46852524
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.46210052
99CTCF_20526341_ChIP-Seq_ESCs_Human0.46165118
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.46084640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.93712601
2MP0005085_abnormal_gallbladder_physiolo6.47229666
3MP0005360_urolithiasis6.06678371
4MP0005365_abnormal_bile_salt6.01203020
5MP0008875_abnormal_xenobiotic_pharmacok5.72000303
6MP0003195_calcinosis4.96577236
7MP0002138_abnormal_hepatobiliary_system4.50207869
8MP0003252_abnormal_bile_duct4.24544523
9MP0003868_abnormal_feces_composition3.62299493
10MP0001666_abnormal_nutrient_absorption3.39320398
11MP0009697_abnormal_copulation2.90890212
12MP0010329_abnormal_lipoprotein_level2.72134270
13MP0003806_abnormal_nucleotide_metabolis2.34215895
14MP0009840_abnormal_foam_cell2.31951516
15MP0005332_abnormal_amino_acid2.31611839
16MP0003191_abnormal_cellular_cholesterol2.16064399
17MP0002876_abnormal_thyroid_physiology1.95726081
18MP0000609_abnormal_liver_physiology1.86058279
19MP0002118_abnormal_lipid_homeostasis1.67503875
20MP0001764_abnormal_homeostasis1.59736631
21MP0010368_abnormal_lymphatic_system1.48175316
22MP0004019_abnormal_vitamin_homeostasis1.33548622
23MP0009053_abnormal_anal_canal1.18715564
24MP0005319_abnormal_enzyme/_coenzyme1.17202736
25MP0005408_hypopigmentation1.14692112
26MP0005670_abnormal_white_adipose1.09350526
27MP0001661_extended_life_span1.03736683
28MP0000598_abnormal_liver_morphology1.03621855
29MP0005584_abnormal_enzyme/coenzyme_acti1.03349484
30MP0002132_abnormal_respiratory_system0.97998211
31MP0009643_abnormal_urine_homeostasis0.96244016
32MP0003656_abnormal_erythrocyte_physiolo0.95033750
33MP0005451_abnormal_body_composition0.93219696
34MP0003186_abnormal_redox_activity0.87393512
35MP0009764_decreased_sensitivity_to0.86928192
36MP0001915_intracranial_hemorrhage0.86044545
37MP0009763_increased_sensitivity_to0.85549421
38MP0000604_amyloidosis0.83935141
39MP0005187_abnormal_penis_morphology0.82570662
40MP0009642_abnormal_blood_homeostasis0.81888881
41MP0005376_homeostasis/metabolism_phenot0.79659454
42MP0008469_abnormal_protein_level0.79118959
43MP0002971_abnormal_brown_adipose0.78859560
44MP0005395_other_phenotype0.71002480
45MP0005636_abnormal_mineral_homeostasis0.70410346
46MP0003879_abnormal_hair_cell0.68596695
47MP0003011_delayed_dark_adaptation0.68268217
48MP0002282_abnormal_trachea_morphology0.66097846
49MP0005535_abnormal_body_temperature0.64874887
50MP0005464_abnormal_platelet_physiology0.64032516
51MP0003690_abnormal_glial_cell0.62599412
52MP0008872_abnormal_physiological_respon0.62481751
53MP0002168_other_aberrant_phenotype0.61036046
54MP0003638_abnormal_response/metabolism_0.59207483
55MP0008874_decreased_physiological_sensi0.58406169
56MP0005266_abnormal_metabolism0.56925992
57MP0002249_abnormal_larynx_morphology0.54856512
58MP0002078_abnormal_glucose_homeostasis0.53427895
59MP0005023_abnormal_wound_healing0.51407447
60MP0005334_abnormal_fat_pad0.48828576
61MP0009785_altered_susceptibility_to0.45392766
62MP0006036_abnormal_mitochondrial_physio0.44995776
63MP0005058_abnormal_lysosome_morphology0.41475955
64MP0000249_abnormal_blood_vessel0.40779219
65MP0009765_abnormal_xenobiotic_induced0.39874196
66MP0004130_abnormal_muscle_cell0.39484864
67MP0005166_decreased_susceptibility_to0.38295807
68MP0005164_abnormal_response_to0.35981379
69MP0003075_altered_response_to0.33915949
70MP0004883_abnormal_blood_vessel0.33339077
71MP0000467_abnormal_esophagus_morphology0.32503565
72MP0005448_abnormal_energy_balance0.31755009
73MP0002136_abnormal_kidney_physiology0.31603094
74MP0004782_abnormal_surfactant_physiolog0.29636681
75MP0003718_maternal_effect0.29537975
76MP0008873_increased_physiological_sensi0.27502913
77MP0002332_abnormal_exercise_endurance0.26262475
78MP0003329_amyloid_beta_deposits0.25140100
79MP0001851_eye_inflammation0.24955094
80MP0005647_abnormal_sex_gland0.24798674
81MP0003705_abnormal_hypodermis_morpholog0.24573145
82MP0003959_abnormal_lean_body0.24552276
83MP0005197_abnormal_uvea_morphology0.23267364
84MP0001845_abnormal_inflammatory_respons0.23240407
85MP0003953_abnormal_hormone_level0.23234649
86MP0009115_abnormal_fat_cell0.22799956
87MP0005220_abnormal_exocrine_pancreas0.20346128
88MP0002090_abnormal_vision0.20004414
89MP0002928_abnormal_bile_duct0.19510748
90MP0002970_abnormal_white_adipose0.18941217
91MP0005083_abnormal_biliary_tract0.18925602
92MP0001756_abnormal_urination0.18556293
93MP0005084_abnormal_gallbladder_morpholo0.18272906
94MP0000920_abnormal_myelination0.16394123
95MP0000566_synostosis0.16221469
96MP0005666_abnormal_adipose_tissue0.15903494
97MP0002089_abnormal_postnatal_growth/wei0.15894355
98MP0002128_abnormal_blood_circulation0.15576198
99MP0003632_abnormal_nervous_system0.14984784
100MP0001881_abnormal_mammary_gland0.14567602

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)9.02533914
2Prolonged partial thromboplastin time (HP:0003645)8.93254136
3Abnormality of aromatic amino acid family metabolism (HP:0004338)8.40165301
4Hypobetalipoproteinemia (HP:0003563)8.04803550
5Abnormality of complement system (HP:0005339)7.33905184
6Conjugated hyperbilirubinemia (HP:0002908)6.95105649
7Systemic lupus erythematosus (HP:0002725)6.12414981
8Joint hemorrhage (HP:0005261)6.07915265
9Hyperlipoproteinemia (HP:0010980)5.92066324
10Intrahepatic cholestasis (HP:0001406)5.56848607
11Glomerulonephritis (HP:0000099)5.01170511
12Abnormality of pyrimidine metabolism (HP:0004353)4.97573974
13Xanthomatosis (HP:0000991)4.82623692
14Abnormality of the common coagulation pathway (HP:0010990)4.70999886
15Hypolipoproteinemia (HP:0010981)4.61668565
16Spontaneous abortion (HP:0005268)4.24284694
17Recurrent gram-negative bacterial infections (HP:0005420)4.20741361
18Abnormality of the intrinsic pathway (HP:0010989)3.99290769
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.96386574
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.79162768
21Nephritis (HP:0000123)3.76297946
22Fat malabsorption (HP:0002630)3.68528270
23Hypoalphalipoproteinemia (HP:0003233)3.34100291
24Hyperglycinemia (HP:0002154)3.32104192
25Hyperammonemia (HP:0001987)3.31196822
26Abnormality of methionine metabolism (HP:0010901)3.21660466
27Generalized aminoaciduria (HP:0002909)3.12253611
28Gingival bleeding (HP:0000225)3.03779988
29Rickets (HP:0002748)2.99758260
30Steatorrhea (HP:0002570)2.95825798
31Vascular calcification (HP:0004934)2.90596879
32Delayed CNS myelination (HP:0002188)2.90382776
33Mitral stenosis (HP:0001718)2.89157148
34Hemorrhage of the eye (HP:0011885)2.86985028
35Abnormality of serine family amino acid metabolism (HP:0010894)2.84236487
36Abnormality of glycine metabolism (HP:0010895)2.84236487
37Hypercholesterolemia (HP:0003124)2.82150044
38Abnormality of nucleobase metabolism (HP:0010932)2.71946355
39Hyperbilirubinemia (HP:0002904)2.68029827
40Osteomalacia (HP:0002749)2.67918164
41Reduced antithrombin III activity (HP:0001976)2.67715297
42Abnormality of serum amino acid levels (HP:0003112)2.65651029
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.59426480
44Hyperglycinuria (HP:0003108)2.57836230
45Cardiovascular calcification (HP:0011915)2.57763738
46Epidermoid cyst (HP:0200040)2.55186542
47Thrombophlebitis (HP:0004418)2.50614926
48Purpura (HP:0000979)2.49168435
49Hepatocellular carcinoma (HP:0001402)2.40648762
50Pulmonary embolism (HP:0002204)2.38901762
51Neonatal hypoglycemia (HP:0001998)2.37850128
52Menorrhagia (HP:0000132)2.34888276
53Fair hair (HP:0002286)2.32883389
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.30294247
55Cholelithiasis (HP:0001081)2.19278139
56Cholecystitis (HP:0001082)2.18730322
57Abnormal gallbladder physiology (HP:0012438)2.18730322
58Metabolic acidosis (HP:0001942)2.17982243
59Hyperphosphaturia (HP:0003109)2.13705882
60Abnormality of vitamin metabolism (HP:0100508)2.13093305
61Abnormality of the Achilles tendon (HP:0005109)2.12461440
62Arthropathy (HP:0003040)2.11940338
63Abnormal gallbladder morphology (HP:0012437)2.07316835
64Elevated alkaline phosphatase (HP:0003155)2.04265640
65Irritability (HP:0000737)2.03428254
66Abnormality of monocarboxylic acid metabolism (HP:0010996)10.6807575
67Deep venous thrombosis (HP:0002625)10.2063009
68Glycosuria (HP:0003076)1.99196827
69Abnormality of urine glucose concentration (HP:0011016)1.99196827
70Myocardial infarction (HP:0001658)1.96820749
71Hypochromic microcytic anemia (HP:0004840)1.94909599
72Abnormal enzyme/coenzyme activity (HP:0012379)1.90373327
73Bifid scrotum (HP:0000048)1.89349433
74Ketosis (HP:0001946)1.87559012
75Joint swelling (HP:0001386)1.85640998
76Abnormality of alkaline phosphatase activity (HP:0004379)1.84768763
77Increased mean platelet volume (HP:0011877)1.82250992
78Increased serum ferritin (HP:0003281)1.81498652
79Hypophosphatemic rickets (HP:0004912)1.81010731
80Abnormality of iron homeostasis (HP:0011031)1.80624396
81Gangrene (HP:0100758)1.75998185
82Hydroxyprolinuria (HP:0003080)1.73722902
83Abnormality of proline metabolism (HP:0010907)1.73722902
84Atrioventricular block (HP:0001678)1.72229895
85Abnormal urine phosphate concentration (HP:0012599)1.71980341
86Poikilocytosis (HP:0004447)1.71520461
87Abnormality of purine metabolism (HP:0004352)1.68533696
88Bile duct proliferation (HP:0001408)1.66865388
89Abnormal biliary tract physiology (HP:0012439)1.66865388
90Abnormal platelet volume (HP:0011876)1.64837402
91Abnormality of transition element cation homeostasis (HP:0011030)1.63501286
92Epistaxis (HP:0000421)1.63286890
93Cerebral palsy (HP:0100021)1.62328340
94Lethargy (HP:0001254)1.60905171
95Generalized hypopigmentation of hair (HP:0011358)1.60487463
96Impaired platelet aggregation (HP:0003540)1.55855680
97Abnormal platelet function (HP:0011869)1.55855680
98Alkalosis (HP:0001948)1.55533646
99Abnormality of the gallbladder (HP:0005264)1.52728012
100Skin nodule (HP:0200036)1.51850473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.51001804
2PIK3CG3.78219419
3FGFR43.62225211
4RIPK13.58539664
5TRIB32.77780631
6TYK22.68543624
7SIK12.49652958
8BCKDK2.41949944
9PRKACG2.29940576
10PRPF4B2.26590111
11PIK3CA2.22469000
12MAP3K31.99260005
13EPHA31.95421265
14MST1R1.87008484
15MAP3K121.82351076
16MAP2K41.81072338
17TBK11.80092134
18NTRK31.74762670
19IRAK31.73743351
20ABL21.71245672
21PRKAA21.69548728
22MAPK111.62335796
23NEK91.52399162
24PRKCG1.51456009
25MYLK1.46150106
26FGFR31.37402248
27IGF1R1.36361482
28TAOK31.34313426
29JAK11.32889818
30PDPK11.25858315
31MAP3K21.13627432
32PINK11.12209900
33EPHA41.09485768
34TNK21.09211819
35NLK1.06713319
36ERBB21.05276905
37PRKCZ1.03213460
38PRKG10.97892260
39JAK20.97559765
40MAP3K10.97497051
41SCYL20.93705366
42TAOK20.91731151
43EPHB10.91514732
44FER0.90521221
45MAP3K110.85944485
46PRKACA0.84854178
47PDK10.82676444
48CAMKK20.78584290
49CDK60.78162151
50PKN20.77813666
51PRKAA10.76944504
52ZAP700.74888630
53RET0.72865014
54CSF1R0.72637542
55ERBB40.71951820
56MAP3K60.69688631
57ARAF0.69613190
58MAP2K30.68654511
59CSNK1D0.67364684
60PRKCB0.66883599
61MAP3K50.64268571
62KSR20.63272388
63PRKCA0.63021529
64PDK20.62898903
65ICK0.62160628
66STK380.60746904
67PTK60.59457945
68MET0.57920898
69RPS6KA30.55725171
70MAPK40.55379509
71KDR0.54775865
72CAMK2G0.54684818
73STK160.54382765
74MAPK70.53983606
75INSRR0.53548935
76DYRK1B0.53071408
77MAPKAPK30.52649943
78MAPK120.52565511
79TGFBR20.52361850
80SGK10.52195424
81GSK3A0.50905879
82SRC0.46106165
83TIE10.45186434
84PRKACB0.44306043
85CSNK1E0.40579130
86EIF2AK10.39941483
87CAMKK10.39134981
88SGK30.38346682
89MAP3K130.38167743
90PIM20.37230115
91CSNK2A10.36525200
92CDK40.36420850
93WNK30.35759343
94MAP2K20.34405752
95MTOR0.34249301
96DAPK20.33251677
97CAMK1D0.32773197
98IKBKE0.31576385
99CSNK1A10.31217695
100CSNK2A20.31163609

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.69788777
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.24283965
3Primary bile acid biosynthesis_Homo sapiens_hsa001204.13866004
4Complement and coagulation cascades_Homo sapiens_hsa046103.74346035
5* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.38714834
6* Retinol metabolism_Homo sapiens_hsa008303.36968939
7* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30059203
8* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.89578138
9* Chemical carcinogenesis_Homo sapiens_hsa052042.89139076
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.74757134
11* Steroid hormone biosynthesis_Homo sapiens_hsa001402.62890525
12* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.55432989
13Arginine biosynthesis_Homo sapiens_hsa002202.53341410
14* Drug metabolism - other enzymes_Homo sapiens_hsa009832.52904095
15Phenylalanine metabolism_Homo sapiens_hsa003602.47528170
16Fatty acid degradation_Homo sapiens_hsa000712.34457938
17Tyrosine metabolism_Homo sapiens_hsa003502.23474841
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17703960
19Butanoate metabolism_Homo sapiens_hsa006502.05687669
20Linoleic acid metabolism_Homo sapiens_hsa005911.89825874
21Tryptophan metabolism_Homo sapiens_hsa003801.87771927
22Bile secretion_Homo sapiens_hsa049761.87623852
23Histidine metabolism_Homo sapiens_hsa003401.83145742
24* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61713525
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51792457
26* Starch and sucrose metabolism_Homo sapiens_hsa005001.41893523
27PPAR signaling pathway_Homo sapiens_hsa033201.41558270
28Vitamin B6 metabolism_Homo sapiens_hsa007501.38783442
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37586798
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.37360326
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35716754
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.34167448
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32873681
34Peroxisome_Homo sapiens_hsa041461.32146985
35beta-Alanine metabolism_Homo sapiens_hsa004101.24648674
36Staphylococcus aureus infection_Homo sapiens_hsa051501.18700779
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15581616
38Arachidonic acid metabolism_Homo sapiens_hsa005901.15004262
39Biosynthesis of amino acids_Homo sapiens_hsa012301.13187747
40Pyruvate metabolism_Homo sapiens_hsa006201.07468994
41Prion diseases_Homo sapiens_hsa050201.05940168
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96761084
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94740199
44Arginine and proline metabolism_Homo sapiens_hsa003300.93786784
45Carbon metabolism_Homo sapiens_hsa012000.87522495
46Propanoate metabolism_Homo sapiens_hsa006400.84096665
47Fat digestion and absorption_Homo sapiens_hsa049750.81355307
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78552376
49Fatty acid metabolism_Homo sapiens_hsa012120.77078860
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76551427
51One carbon pool by folate_Homo sapiens_hsa006700.75940614
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75361249
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75055640
54ABC transporters_Homo sapiens_hsa020100.75042568
55Sulfur metabolism_Homo sapiens_hsa009200.57979899
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.53212334
57Sulfur relay system_Homo sapiens_hsa041220.52410057
58Lysine degradation_Homo sapiens_hsa003100.49257522
59* Metabolic pathways_Homo sapiens_hsa011000.42272011
60Pertussis_Homo sapiens_hsa051330.29181957
61Glycerolipid metabolism_Homo sapiens_hsa005610.27173771
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26001072
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25691366
64Fatty acid elongation_Homo sapiens_hsa000620.25338737
65Fructose and mannose metabolism_Homo sapiens_hsa000510.23721664
66Pentose phosphate pathway_Homo sapiens_hsa000300.23606861
67Insulin resistance_Homo sapiens_hsa049310.19940894
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.12623908
69Glucagon signaling pathway_Homo sapiens_hsa049220.10887620
70Vitamin digestion and absorption_Homo sapiens_hsa049770.10855772
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07843995
72Steroid biosynthesis_Homo sapiens_hsa001000.07253565
73Glutathione metabolism_Homo sapiens_hsa004800.06749804
74Systemic lupus erythematosus_Homo sapiens_hsa053220.06092623
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.05839420
76Folate biosynthesis_Homo sapiens_hsa007900.03798047
77Selenocompound metabolism_Homo sapiens_hsa004500.03669286
78Galactose metabolism_Homo sapiens_hsa000520.01908504
79Other glycan degradation_Homo sapiens_hsa005110.00977316
80Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2767432
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.2743844
82Ether lipid metabolism_Homo sapiens_hsa00565-0.2633945
83Circadian rhythm_Homo sapiens_hsa04710-0.2568918
84Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2544508
85N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2411449
86Type II diabetes mellitus_Homo sapiens_hsa04930-0.2368492
87Nitrogen metabolism_Homo sapiens_hsa00910-0.2143716
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.2005467
89Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1747960
90Insulin signaling pathway_Homo sapiens_hsa04910-0.1662108
91Sphingolipid metabolism_Homo sapiens_hsa00600-0.1649631
92African trypanosomiasis_Homo sapiens_hsa05143-0.1107432
93Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1058753
94Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1035043
95Amoebiasis_Homo sapiens_hsa05146-0.0528880
96Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0490012
97Mineral absorption_Homo sapiens_hsa04978-0.0448154
98AMPK signaling pathway_Homo sapiens_hsa04152-0.0222518
99Serotonergic synapse_Homo sapiens_hsa04726-0.0027969
100Renin-angiotensin system_Homo sapiens_hsa04614-0.0018705

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