UGT1A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.63144359
2epoxygenase P450 pathway (GO:0019373)8.51200553
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.73779962
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.64357091
5L-phenylalanine catabolic process (GO:0006559)7.64357091
6lipoprotein transport (GO:0042953)7.34844901
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.28688557
8L-phenylalanine metabolic process (GO:0006558)7.28688557
9aromatic amino acid family catabolic process (GO:0009074)6.76464830
10fat-soluble vitamin biosynthetic process (GO:0042362)6.71631030
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.56544991
12intestinal absorption (GO:0050892)6.07267400
13alpha-linolenic acid metabolic process (GO:0036109)5.96291189
14tryptophan catabolic process (GO:0006569)5.95834611
15indole-containing compound catabolic process (GO:0042436)5.95834611
16indolalkylamine catabolic process (GO:0046218)5.95834611
17kynurenine metabolic process (GO:0070189)5.83946378
18bile acid biosynthetic process (GO:0006699)5.74144339
19high-density lipoprotein particle remodeling (GO:0034375)5.73436387
20NADH metabolic process (GO:0006734)5.71631146
21regulation of guanylate cyclase activity (GO:0031282)5.70081500
22hormone catabolic process (GO:0042447)5.68528368
23tryptophan metabolic process (GO:0006568)5.63407128
24urea metabolic process (GO:0019627)5.57537683
25urea cycle (GO:0000050)5.57537683
26phenylpropanoid metabolic process (GO:0009698)5.53286057
27glyoxylate metabolic process (GO:0046487)5.48189152
28negative regulation of fibrinolysis (GO:0051918)5.44288462
29sulfur amino acid catabolic process (GO:0000098)5.34360980
30omega-hydroxylase P450 pathway (GO:0097267)5.30142396
31protein carboxylation (GO:0018214)5.27857233
32peptidyl-glutamic acid carboxylation (GO:0017187)5.27857233
33cysteine metabolic process (GO:0006534)5.21679375
34regulation of fibrinolysis (GO:0051917)5.19407293
35nitrogen cycle metabolic process (GO:0071941)5.12285728
36serine family amino acid catabolic process (GO:0009071)5.11907206
37regulation of cholesterol esterification (GO:0010872)5.09585518
38bile acid metabolic process (GO:0008206)5.08731966
39reverse cholesterol transport (GO:0043691)4.93433689
40aromatic amino acid family metabolic process (GO:0009072)4.91177987
41tyrosine metabolic process (GO:0006570)4.87160683
42negative regulation of cholesterol transport (GO:0032375)4.86215634
43negative regulation of sterol transport (GO:0032372)4.86215634
44protein-lipid complex remodeling (GO:0034368)4.84350521
45macromolecular complex remodeling (GO:0034367)4.84350521
46plasma lipoprotein particle remodeling (GO:0034369)4.84350521
47regulation of triglyceride catabolic process (GO:0010896)4.80016077
48phospholipid efflux (GO:0033700)4.74605450
49regulation of protein activation cascade (GO:2000257)4.71790445
50complement activation, alternative pathway (GO:0006957)4.70172376
51homocysteine metabolic process (GO:0050667)4.68841228
52positive regulation of guanylate cyclase activity (GO:0031284)4.68112081
53fructose metabolic process (GO:0006000)4.67258583
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.66993701
55regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.66712777
56endocrine process (GO:0050886)4.66712777
57regulation of systemic arterial blood pressure by hormone (GO:0001990)4.66712777
58alpha-amino acid catabolic process (GO:1901606)4.64169972
59amino-acid betaine metabolic process (GO:0006577)4.63814054
60daunorubicin metabolic process (GO:0044597)4.62593990
61polyketide metabolic process (GO:0030638)4.62593990
62doxorubicin metabolic process (GO:0044598)4.62593990
63triglyceride homeostasis (GO:0070328)4.60808858
64acylglycerol homeostasis (GO:0055090)4.60808858
65cellular ketone body metabolic process (GO:0046950)4.58661608
66bile acid and bile salt transport (GO:0015721)4.50444324
67lysine metabolic process (GO:0006553)4.48418381
68lysine catabolic process (GO:0006554)4.48418381
69plasma lipoprotein particle clearance (GO:0034381)4.47945882
70drug catabolic process (GO:0042737)4.38911712
71glycine metabolic process (GO:0006544)4.35149848
72cellular glucuronidation (GO:0052695)4.34761978
73regulation of complement activation (GO:0030449)4.33447983
74imidazole-containing compound metabolic process (GO:0052803)4.30509025
75alkaloid metabolic process (GO:0009820)4.29568475
76cholesterol efflux (GO:0033344)4.28855639
77cellular amino acid catabolic process (GO:0009063)4.26144032
78coenzyme catabolic process (GO:0009109)4.23437643
79indolalkylamine metabolic process (GO:0006586)4.23386904
80glutamate metabolic process (GO:0006536)4.21119490
81ethanol oxidation (GO:0006069)4.20697993
82cellular biogenic amine catabolic process (GO:0042402)4.18049917
83amine catabolic process (GO:0009310)4.18049917
84low-density lipoprotein particle remodeling (GO:0034374)4.15566054
85benzene-containing compound metabolic process (GO:0042537)4.14497328
86virion attachment to host cell (GO:0019062)4.11485324
87adhesion of symbiont to host cell (GO:0044650)4.11485324
88heme transport (GO:0015886)4.10400037
89plasma lipoprotein particle assembly (GO:0034377)4.09422007
90digestion (GO:0007586)4.09358522
91aminoglycoside antibiotic metabolic process (GO:0030647)4.08816549
92regulation of systemic arterial blood pressure (GO:0003073)4.08567894
93serine family amino acid metabolic process (GO:0009069)4.08293804
94negative regulation of steroid metabolic process (GO:0045939)4.07565351
95glycoside metabolic process (GO:0016137)4.07317255
96fat-soluble vitamin metabolic process (GO:0006775)4.05037820
97lipoprotein metabolic process (GO:0042157)4.04208794
98cellular modified amino acid catabolic process (GO:0042219)4.02010677
99dicarboxylic acid biosynthetic process (GO:0043650)4.01409597
100drug transmembrane transport (GO:0006855)4.00765347
101arginine metabolic process (GO:0006525)3.99901517
102ketone body metabolic process (GO:1902224)3.97004459
103short-chain fatty acid metabolic process (GO:0046459)3.92580884
104aldehyde catabolic process (GO:0046185)3.92564154
105serine family amino acid biosynthetic process (GO:0009070)3.91670663
106negative regulation of lipase activity (GO:0060192)3.90696284
107positive regulation of lipid catabolic process (GO:0050996)3.89651057
108renal system process involved in regulation of blood volume (GO:0001977)3.87387419
109fibrinolysis (GO:0042730)3.86155706
110vitamin A metabolic process (GO:0006776)3.85814244
111glucuronate metabolic process (GO:0019585)3.85639341
112uronic acid metabolic process (GO:0006063)3.85639341
113phospholipid homeostasis (GO:0055091)3.85452081
114peptide hormone processing (GO:0016486)3.81101761
115very-low-density lipoprotein particle assembly (GO:0034379)3.80276737
116drug transport (GO:0015893)3.79726290
117flavonoid metabolic process (GO:0009812)3.78735052
118cholesterol homeostasis (GO:0042632)3.78602231
119drug metabolic process (GO:0017144)3.77130774
120cofactor catabolic process (GO:0051187)3.76993583
121organic acid catabolic process (GO:0016054)3.76765136
122carboxylic acid catabolic process (GO:0046395)3.76765136
123drinking behavior (GO:0042756)3.76312157
124regulation of bile acid biosynthetic process (GO:0070857)3.74428638
125primary alcohol catabolic process (GO:0034310)3.73905878
126positive regulation of triglyceride lipase activity (GO:0061365)3.73487899
127positive regulation of lipoprotein lipase activity (GO:0051006)3.73487899
128acetyl-CoA metabolic process (GO:0006084)3.72438786
129sterol homeostasis (GO:0055092)3.72198141
130vitamin transport (GO:0051180)3.71639231
131blood coagulation, intrinsic pathway (GO:0007597)3.70823868
132protein-lipid complex assembly (GO:0065005)3.67550953
133plasma lipoprotein particle organization (GO:0071827)3.67263751
134vitamin D metabolic process (GO:0042359)3.60668141
135adhesion of symbiont to host (GO:0044406)3.59696450
136vitamin biosynthetic process (GO:0009110)3.59389203
137regulation of cholesterol homeostasis (GO:2000188)3.59314054
138mRNA modification (GO:0016556)3.58978388
139diacylglycerol metabolic process (GO:0046339)3.58142160
140exogenous drug catabolic process (GO:0042738)3.57835196
141positive regulation of fatty acid beta-oxidation (GO:0032000)3.55131170
142nicotinamide nucleotide biosynthetic process (GO:0019359)3.54315587
143pyridine nucleotide biosynthetic process (GO:0019363)3.54315587
144vitamin transmembrane transport (GO:0035461)3.47367401
145glycolipid catabolic process (GO:0019377)3.45270541
146urate metabolic process (GO:0046415)3.44293729
147phenol-containing compound catabolic process (GO:0019336)3.44191049
148regulation of vitamin metabolic process (GO:0030656)3.41816883
149glutamine family amino acid biosynthetic process (GO:0009084)3.41555066
150regulation of cGMP biosynthetic process (GO:0030826)3.39591265
151glycosphingolipid catabolic process (GO:0046479)3.39141304
152sulfate transmembrane transport (GO:1902358)3.38314623
153midgut development (GO:0007494)3.35323877
154citrulline biosynthetic process (GO:0019240)3.33705340
155maintenance of gastrointestinal epithelium (GO:0030277)3.32767006
156oxidative demethylation (GO:0070989)3.25924561
157phosphate ion transmembrane transport (GO:0035435)3.21591036
158quinone metabolic process (GO:1901661)3.21170397
159xenobiotic metabolic process (GO:0006805)3.20179401
160intestinal cholesterol absorption (GO:0030299)3.14204423
161receptor guanylyl cyclase signaling pathway (GO:0007168)3.11712789
162cyclooxygenase pathway (GO:0019371)3.08648374
163peptide catabolic process (GO:0043171)3.07772866
164arachidonic acid metabolic process (GO:0019369)3.01248005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.42602884
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18813930
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.87214679
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.54298614
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28323430
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.10659490
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.95690140
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.98029009
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.97801996
10* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.40252915
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.40196385
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.22812997
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.22521940
14FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.09623198
15* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04378309
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8625700
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97887157
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97711161
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.97012782
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.93783402
21AR_21909140_ChIP-Seq_LNCAP_Human1.86736625
22TCF4_18268006_ChIP-ChIP_LS174T_Human1.78764445
23CLOCK_20551151_ChIP-Seq_293T_Human1.61775031
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.60390189
25HTT_18923047_ChIP-ChIP_STHdh_Human1.57275821
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54022903
27HNF4A_19822575_ChIP-Seq_HepG2_Human1.40751415
28GATA1_22025678_ChIP-Seq_K562_Human1.34821176
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27494004
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26598289
31TP63_23658742_ChIP-Seq_EP156T_Human1.21638683
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20856203
33KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18805939
34ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17718420
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16597855
36RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15496228
37P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13292067
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11257143
39CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10854251
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08015450
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05274049
42KLF5_25053715_ChIP-Seq_YYC3_Human1.04857719
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03475090
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02916285
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01306305
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99625735
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98097626
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95888303
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95865337
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94795023
51SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93587937
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91922320
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91133085
54AHR_22903824_ChIP-Seq_MCF-7_Human0.89316301
55IRF8_22096565_ChIP-ChIP_GC-B_Human0.89078198
56* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88343298
57* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88343298
58AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86820299
59ZNF263_19887448_ChIP-Seq_K562_Human0.86169609
60TP53_18474530_ChIP-ChIP_U2OS_Human0.85519540
61FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85204696
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84784175
63PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83929708
64RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83027986
65* GATA4_25053715_ChIP-Seq_YYC3_Human0.82937247
66CJUN_26792858_Chip-Seq_BT549_Human0.82271900
67RXR_22108803_ChIP-Seq_LS180_Human0.82184833
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81866441
69RUNX1_27514584_Chip-Seq_MCF-7_Human0.81316341
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80650500
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80534040
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79348159
73HNFA_21074721_ChIP-Seq_CACO-2_Human0.76753491
74RACK7_27058665_Chip-Seq_MCF-7_Human0.75909465
75* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75548722
76TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74792889
77SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71912227
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71233029
79JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.70965169
80TCF4_22108803_ChIP-Seq_LS180_Human0.70636206
81* RARA_24833708_ChIP-Seq_LIVER_Mouse0.69930029
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.69342464
83SOX9_24532713_ChIP-Seq_HFSC_Mouse0.69049351
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.68969873
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.68822336
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.68822336
87AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68352987
88SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67724212
89NFYA_21822215_ChIP-Seq_K562_Human0.67676608
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.67105892
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.66861081
92ESR2_21235772_ChIP-Seq_MCF-7_Human0.65318438
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65062376
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65062376
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64266658
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63859655
97RARB_24833708_ChIP-Seq_LIVER_Mouse0.60902212
98* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60050238
99RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59316364
100* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.58977035
101CEBPB_22108803_ChIP-Seq_LS180_Human0.58904691
102LXR_22292898_ChIP-Seq_THP-1_Human0.55795139
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55410419
104FOXA1_25552417_ChIP-Seq_VCAP_Human0.53276158
105EGR1_19032775_ChIP-ChIP_M12_Human0.52991663
106ESET_19884257_ChIP-Seq_ESCs_Mouse0.50595993
107MYC_19915707_ChIP-ChIP_AK7_Human0.50050072
108STAT1_17558387_ChIP-Seq_HELA_Human0.49854474
109CBP_21632823_ChIP-Seq_H3396_Human0.49299393
110AR_20517297_ChIP-Seq_VCAP_Human0.48885689
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48171715
112GATA1_19941826_ChIP-Seq_K562_Human0.48063691
113P53_21459846_ChIP-Seq_SAOS-2_Human0.48059731
114PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47955206
115* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.47675085
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46451042
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.46226558
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.44575237
119TAF15_26573619_Chip-Seq_HEK293_Human0.43940692
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43157611
121GATA2_19941826_ChIP-Seq_K562_Human0.42879653
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42306446
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.42106396
124BCAT_22108803_ChIP-Seq_LS180_Human0.41997370
125* GATA1_19941827_ChIP-Seq_MEL_Mouse0.41548231
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.41547958
127GATA6_25053715_ChIP-Seq_YYC3_Human0.41159143
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40046217
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.39863469
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.39376069
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.38922699
132TAF2_19829295_ChIP-Seq_ESCs_Human0.38034331
133LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.38003513
134* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37235928
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.36778252
136CDX2_22108803_ChIP-Seq_LS180_Human0.36028787
137MYC_27129775_Chip-Seq_CORNEA_Mouse0.35584835
138STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.35434261
139NCOR_22424771_ChIP-Seq_293T_Human0.34506740
140SOX2_20726797_ChIP-Seq_SW620_Human0.34080569
141CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33608898
142* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.33565562
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.33444467
144GATA3_24758297_ChIP-Seq_MCF-7_Human0.32922819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.49239531
2MP0005360_urolithiasis7.45335345
3MP0005085_abnormal_gallbladder_physiolo6.41192035
4MP0005365_abnormal_bile_salt6.15432053
5MP0008875_abnormal_xenobiotic_pharmacok5.44072718
6MP0003183_abnormal_peptide_metabolism4.38123882
7MP0003806_abnormal_nucleotide_metabolis4.07784802
8MP0003252_abnormal_bile_duct3.86131414
9MP0010329_abnormal_lipoprotein_level3.61511971
10MP0009840_abnormal_foam_cell3.42403654
11MP0005083_abnormal_biliary_tract3.20850254
12MP0004147_increased_porphyrin_level3.18613887
13MP0004264_abnormal_extraembryonic_tissu3.17998159
14MP0003195_calcinosis2.82595552
15MP0005332_abnormal_amino_acid2.75182447
16MP0001666_abnormal_nutrient_absorption2.55104100
17MP0009379_abnormal_foot_pigmentation2.48919583
18MP0004019_abnormal_vitamin_homeostasis2.19804370
19MP0003191_abnormal_cellular_cholesterol2.17892900
20MP0000609_abnormal_liver_physiology2.16149649
21MP0002118_abnormal_lipid_homeostasis2.14617959
22MP0010234_abnormal_vibrissa_follicle2.00838707
23MP0002138_abnormal_hepatobiliary_system1.89364930
24MP0003868_abnormal_feces_composition1.87097711
25MP0005319_abnormal_enzyme/_coenzyme1.80594707
26MP0010155_abnormal_intestine_physiology1.74258929
27MP0005451_abnormal_body_composition1.68375028
28MP0001764_abnormal_homeostasis1.64962616
29MP0005409_darkened_coat_color1.64721024
30MP0009697_abnormal_copulation1.59664628
31MP0005584_abnormal_enzyme/coenzyme_acti1.58521920
32MP0001664_abnormal_digestion1.48790027
33MP0003011_delayed_dark_adaptation1.38418780
34MP0003866_abnormal_defecation1.37389369
35MP0003186_abnormal_redox_activity1.26208316
36MP0001765_abnormal_ion_homeostasis1.25346697
37MP0009643_abnormal_urine_homeostasis1.22284517
38MP0003656_abnormal_erythrocyte_physiolo1.21488796
39MP0000538_abnormal_urinary_bladder1.16592540
40MP0000598_abnormal_liver_morphology1.16231128
41MP0002638_abnormal_pupillary_reflex1.13416984
42MP0000604_amyloidosis1.12157270
43MP0000490_abnormal_crypts_of1.10963477
44MP0003705_abnormal_hypodermis_morpholog1.09467684
45MP0010352_gastrointestinal_tract_polyps1.06965503
46MP0005647_abnormal_sex_gland1.04833413
47MP0009764_decreased_sensitivity_to1.03392949
48MP0000477_abnormal_intestine_morphology1.01758973
49MP0009763_increased_sensitivity_to1.00887665
50MP0002254_reproductive_system_inflammat0.96185650
51MP0002098_abnormal_vibrissa_morphology0.95864725
52MP0003879_abnormal_hair_cell0.94723877
53MP0004043_abnormal_pH_regulation0.94501920
54MP0000678_abnormal_parathyroid_gland0.87893461
55MP0005636_abnormal_mineral_homeostasis0.86861084
56MP0009642_abnormal_blood_homeostasis0.86825505
57MP0005408_hypopigmentation0.85688903
58MP0008469_abnormal_protein_level0.85227407
59MP0005670_abnormal_white_adipose0.84964587
60MP0010368_abnormal_lymphatic_system0.82269639
61MP0006036_abnormal_mitochondrial_physio0.81382460
62MP0001501_abnormal_sleep_pattern0.80853793
63MP0002396_abnormal_hematopoietic_system0.80585563
64MP0002078_abnormal_glucose_homeostasis0.80131468
65MP0009765_abnormal_xenobiotic_induced0.79987929
66MP0005376_homeostasis/metabolism_phenot0.78132765
67MP0000462_abnormal_digestive_system0.76029110
68MP0005501_abnormal_skin_physiology0.74866565
69MP0002971_abnormal_brown_adipose0.74839830
70MP0002876_abnormal_thyroid_physiology0.74588903
71MP0000566_synostosis0.74046796
72MP0005084_abnormal_gallbladder_morpholo0.73636239
73MP0005334_abnormal_fat_pad0.72970951
74MP0004130_abnormal_muscle_cell0.70415684
75MP0003690_abnormal_glial_cell0.70207393
76MP0001873_stomach_inflammation0.69010224
77MP0001661_extended_life_span0.68574718
78MP0001188_hyperpigmentation0.67979477
79MP0003329_amyloid_beta_deposits0.66980203
80MP0001663_abnormal_digestive_system0.66836735
81MP0004858_abnormal_nervous_system0.65876181
82MP0009053_abnormal_anal_canal0.65235437
83MP0005535_abnormal_body_temperature0.64915845
84MP0005220_abnormal_exocrine_pancreas0.64585159
85MP0005266_abnormal_metabolism0.63850476
86MP0001756_abnormal_urination0.62273050
87MP0006138_congestive_heart_failure0.60843272
88MP0005448_abnormal_energy_balance0.60779150
89MP0000639_abnormal_adrenal_gland0.60502967
90MP0002938_white_spotting0.60247047
91MP0005381_digestive/alimentary_phenotyp0.56056934
92MP0002822_catalepsy0.55340487
93MP0005464_abnormal_platelet_physiology0.54899353
94MP0006035_abnormal_mitochondrial_morpho0.54111234
95MP0004270_analgesia0.50782097
96MP0010678_abnormal_skin_adnexa0.50296395
97MP0008874_decreased_physiological_sensi0.49276298
98MP0003638_abnormal_response/metabolism_0.48962917
99MP0005395_other_phenotype0.47778171
100MP0008873_increased_physiological_sensi0.46646247
101MP0002136_abnormal_kidney_physiology0.46208464
102MP0003718_maternal_effect0.43880012
103MP0003436_decreased_susceptibility_to0.43543050
104MP0002837_dystrophic_cardiac_calcinosis0.43177444
105MP0003953_abnormal_hormone_level0.42587210
106MP0004782_abnormal_surfactant_physiolog0.42316326
107MP0005248_abnormal_Harderian_gland0.42093182
108MP0008872_abnormal_physiological_respon0.42068371
109MP0003075_altered_response_to0.41796185
110MP0001216_abnormal_epidermal_layer0.41063363
111MP0000537_abnormal_urethra_morphology0.41048974
112MP0002928_abnormal_bile_duct0.40459098
113MP0003724_increased_susceptibility_to0.40382060
114MP0000427_abnormal_hair_cycle0.39082242
115MP0009672_abnormal_birth_weight0.38805779
116MP0005666_abnormal_adipose_tissue0.38087997
117MP0003453_abnormal_keratinocyte_physiol0.36255558
118MP0002135_abnormal_kidney_morphology0.36218196
119MP0001243_abnormal_dermal_layer0.35754948
120MP0009115_abnormal_fat_cell0.34951881
121MP0004947_skin_inflammation0.34682402
122MP0000249_abnormal_blood_vessel0.34155301
123MP0002168_other_aberrant_phenotype0.34026197
124MP0002970_abnormal_white_adipose0.32795474
125MP0001853_heart_inflammation0.32311574
126MP0005023_abnormal_wound_healing0.32105471
127MP0004883_abnormal_blood_vessel0.32011145
128MP0000230_abnormal_systemic_arterial0.31921621
129MP0001485_abnormal_pinna_reflex0.31450264
130MP0002090_abnormal_vision0.31331470
131MP0006082_CNS_inflammation0.30231500
132MP0002796_impaired_skin_barrier0.29514618
133MP0005166_decreased_susceptibility_to0.29281618
134MP0001845_abnormal_inflammatory_respons0.27897941
135MP0001881_abnormal_mammary_gland0.26971170
136MP0005167_abnormal_blood-brain_barrier0.24697583
137MP0000579_abnormal_nail_morphology0.24641208
138MP0005164_abnormal_response_to0.23550580
139MP0005058_abnormal_lysosome_morphology0.23128172
140MP0002060_abnormal_skin_morphology0.22779557
141MP0003300_gastrointestinal_ulcer0.21765945

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.59941388
2Deep venous thrombosis (HP:0002625)7.46345530
3Intrahepatic cholestasis (HP:0001406)7.10208867
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.75322541
5Hypobetalipoproteinemia (HP:0003563)6.68516362
6Prolonged partial thromboplastin time (HP:0003645)6.45012622
7Xanthomatosis (HP:0000991)6.29777607
8Hyperlipoproteinemia (HP:0010980)5.81172223
9Hypolipoproteinemia (HP:0010981)4.90837407
10Joint hemorrhage (HP:0005261)4.78203516
11Abnormality of the vitamin B12 metabolism (HP:0004341)4.69691598
12Hyperammonemia (HP:0001987)4.65795315
13Widely patent fontanelles and sutures (HP:0004492)4.60199914
14Epidermoid cyst (HP:0200040)4.53336312
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.50346367
16Abnormality of methionine metabolism (HP:0010901)4.43883611
17Hyperglycinemia (HP:0002154)4.39015039
18Complement deficiency (HP:0004431)4.37881892
19Abnormality of vitamin B metabolism (HP:0004340)4.36662788
20Ketosis (HP:0001946)4.30407905
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.28940087
22Abnormality of the common coagulation pathway (HP:0010990)4.24629665
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.23259312
24Hypoalphalipoproteinemia (HP:0003233)4.22698803
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.21536660
26Chronic diarrhea (HP:0002028)4.12002906
27Confusion (HP:0001289)4.04249440
28Ileus (HP:0002595)4.00143479
29Hyperglycinuria (HP:0003108)3.99564006
30Abnormality of serine family amino acid metabolism (HP:0010894)3.96684570
31Abnormality of glycine metabolism (HP:0010895)3.96684570
32Hypoglycemic coma (HP:0001325)3.93128914
33Fat malabsorption (HP:0002630)3.92949110
34Abnormality of pyrimidine metabolism (HP:0004353)3.92426837
35Abnormality of urine glucose concentration (HP:0011016)3.87172576
36Glycosuria (HP:0003076)3.87172576
37Hypercholesterolemia (HP:0003124)3.81638842
38Conjugated hyperbilirubinemia (HP:0002908)3.75282731
39Hyperactive renin-angiotensin system (HP:0000841)3.65538616
40Abnormality of the intrinsic pathway (HP:0010989)3.60566234
41Pigmentary retinal degeneration (HP:0001146)3.53786458
42Thin bony cortex (HP:0002753)3.46623229
43Hyperbilirubinemia (HP:0002904)3.46598002
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39823034
45Proximal tubulopathy (HP:0000114)3.38681017
46Abnormality of fatty-acid metabolism (HP:0004359)3.37015470
47Hyperuricemia (HP:0002149)3.28435984
48Increased purine levels (HP:0004368)3.28435984
49Abnormal urine phosphate concentration (HP:0012599)3.20846477
50Abnormality of complement system (HP:0005339)3.18289478
51Wide cranial sutures (HP:0010537)3.17513011
52Abdominal distention (HP:0003270)3.16794262
53Delayed CNS myelination (HP:0002188)3.15669540
54Nephrolithiasis (HP:0000787)3.13072167
55Abnormality of nucleobase metabolism (HP:0010932)3.11748428
56Abnormality of serum amino acid levels (HP:0003112)3.08606987
57Ketoacidosis (HP:0001993)3.08268767
58Megaloblastic anemia (HP:0001889)3.00738098
59Nausea (HP:0002018)2.97096493
60Decreased circulating renin level (HP:0003351)2.97053589
61Facial shape deformation (HP:0011334)2.95859198
62Potter facies (HP:0002009)2.95859198
63Hyperphosphaturia (HP:0003109)2.95468250
64Hypophosphatemia (HP:0002148)2.93631664
65Hepatocellular carcinoma (HP:0001402)2.93134921
66Myocardial infarction (HP:0001658)2.92470470
67Steatorrhea (HP:0002570)2.90302479
68Enlarged epiphyses (HP:0010580)2.83564286
69Focal segmental glomerulosclerosis (HP:0000097)2.81382869
70Metabolic acidosis (HP:0001942)2.81361171
71Skin nodule (HP:0200036)2.79334281
72Spontaneous abortion (HP:0005268)2.77865617
73Hypochromic microcytic anemia (HP:0004840)2.71913024
74Abnormality of purine metabolism (HP:0004352)2.71409224
75Vascular calcification (HP:0004934)2.70077775
76Osteomalacia (HP:0002749)2.66544455
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66271134
78Dicarboxylic aciduria (HP:0003215)2.66271134
79Delayed epiphyseal ossification (HP:0002663)2.64577383
80Acanthocytosis (HP:0001927)2.63863687
81Lethargy (HP:0001254)2.62459299
82Abnormal gallbladder morphology (HP:0012437)2.56413377
83Hypoglycemic seizures (HP:0002173)2.53285901
84Renal tubular dysfunction (HP:0000124)2.53149502
85Spastic diplegia (HP:0001264)2.48693070
86Right ventricular cardiomyopathy (HP:0011663)2.47997951
87Glomerulonephritis (HP:0000099)2.46124641
88Cholelithiasis (HP:0001081)2.45283485
89Cholecystitis (HP:0001082)2.44331184
90Abnormal gallbladder physiology (HP:0012438)2.44331184
91Cerebral edema (HP:0002181)2.43241276
92Mitral stenosis (HP:0001718)2.43061743
93Irritability (HP:0000737)2.40821392
94Metabolic alkalosis (HP:0200114)2.40451255
95Cardiovascular calcification (HP:0011915)2.39766674
96Abnormality of renin-angiotensin system (HP:0000847)2.36651471
97Systemic lupus erythematosus (HP:0002725)2.33153737
98Gout (HP:0001997)2.31322972
99Malnutrition (HP:0004395)2.31180085
100Amyloidosis (HP:0011034)2.28367556
101Renal tubular acidosis (HP:0001947)2.28223420
102Posterior subcapsular cataract (HP:0007787)2.26864432
103Neonatal onset (HP:0003623)2.24407978
104Esophageal varix (HP:0002040)2.23429888
105Menorrhagia (HP:0000132)2.20345126
106Abnormality of the costochondral junction (HP:0000919)2.18670101
107Brushfield spots (HP:0001088)2.18327583
108Glomerulosclerosis (HP:0000096)2.17994258
109Late onset (HP:0003584)2.14714754
110Abnormality of alkaline phosphatase activity (HP:0004379)2.11205371
111Gingival bleeding (HP:0000225)2.10834749
112Pancreatitis (HP:0001733)2.08064999
113Vomiting (HP:0002013)2.08032759
114Subcapsular cataract (HP:0000523)2.08026487
115Poikilocytosis (HP:0004447)2.07236044
116Generalized aminoaciduria (HP:0002909)2.05730928
117Abnormality of the gallbladder (HP:0005264)2.04508982
118Hyperinsulinemic hypoglycemia (HP:0000825)2.04111413
119Enlarged kidneys (HP:0000105)2.03365076
120Sensorimotor neuropathy (HP:0007141)2.01937633
121Opisthotonus (HP:0002179)2.01669476
122Elevated alkaline phosphatase (HP:0003155)2.00692328
123Thrombophlebitis (HP:0004418)2.00153570
124Hypotension (HP:0002615)1.99962363
125Hyperparathyroidism (HP:0000843)1.99696273
126Hydroxyprolinuria (HP:0003080)1.98958827
127Abnormality of proline metabolism (HP:0010907)1.98958827
128Villous atrophy (HP:0011473)1.98404299
129Abnormality of small intestinal villus morphology (HP:0011472)1.98404299
130Hemorrhage of the eye (HP:0011885)1.97234918
131Abnormal cartilage morphology (HP:0002763)1.94874556
132Rickets (HP:0002748)1.94743356
133Alkalosis (HP:0001948)1.94403729
134Renal cortical cysts (HP:0000803)1.89766915
135Cerebral palsy (HP:0100021)1.89270899
136Dehydration (HP:0001944)1.88568273
137Protuberant abdomen (HP:0001538)1.88138612
138Hypophosphatemic rickets (HP:0004912)1.87851213
139Abnormal glucose tolerance (HP:0001952)1.85552279
140Abnormality of iron homeostasis (HP:0011031)1.83987109
141Congenital sensorineural hearing impairment (HP:0008527)1.83078289
142Reticulocytosis (HP:0001923)1.82080384
143Abnormality of transition element cation homeostasis (HP:0011030)1.81338799
144Status epilepticus (HP:0002133)1.80226173
145Flat acetabular roof (HP:0003180)1.79950999
146Abnormality of vitamin metabolism (HP:0100508)1.77902521
147Abnormal enzyme/coenzyme activity (HP:0012379)1.77869777
148Elevated hepatic transaminases (HP:0002910)1.77284135
149Nephritis (HP:0000123)1.75974060
150Recurrent gram-negative bacterial infections (HP:0005420)1.73175145
151Hyperaldosteronism (HP:0000859)1.71916379
152Gingivitis (HP:0000230)1.70358493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.44284370
2BCKDK7.13239334
3SIK14.82767778
4FGFR44.33254861
5ERN13.89957700
6PRKG23.20889023
7EPHA23.14680112
8PKN23.09282322
9TAOK32.99544454
10INSRR2.98578526
11MST42.78111318
12MAP3K22.68839252
13STK392.48800643
14MAP3K122.45627123
15FLT32.42152695
16MAP2K42.28413654
17ERBB42.20316916
18MST1R2.15060454
19PIK3CG1.83914926
20OXSR11.83502240
21TYK21.77667334
22TRIB31.77510582
23AKT31.72194036
24DAPK21.67442922
25MAPK111.57642314
26LATS11.52577962
27ABL21.51279631
28PTK61.48667559
29FRK1.43665033
30STK241.43624971
31TNIK1.42709740
32FGFR21.40890168
33LMTK21.33921924
34KDR1.33024809
35MAP3K71.28568717
36NEK91.27775174
37PRKAA21.27619424
38JAK21.20550831
39CAMK1D1.15281742
40MYLK1.15220576
41EPHB21.12958096
42PINK11.11809305
43MAP3K141.10485403
44TBK11.10368897
45MAP2K31.08792993
46GRK61.06817829
47PDK21.05204867
48PAK41.03848703
49MAPK41.00839087
50JAK11.00625894
51PIM10.99897971
52MAP3K100.94750355
53PRKCZ0.93917218
54TESK20.92070265
55CSK0.88679009
56ERBB20.85919450
57MAP3K30.85871133
58BRSK20.85731157
59MET0.82025459
60PRKACG0.81159808
61IRAK10.79714667
62MAPK120.79524885
63EPHB10.78912848
64CDK60.78673409
65MAPK150.75301539
66STK38L0.74484887
67DYRK1B0.74313723
68MAP2K60.71218069
69MAP3K110.70849934
70TIE10.70792294
71TGFBR20.68916831
72PRKAA10.68676761
73GSK3A0.66488881
74SGK30.64011678
75CSF1R0.60720451
76BMPR20.60596486
77RPS6KB20.60134170
78RIPK10.59121759
79EPHA40.58895124
80CAMK2G0.58762418
81FER0.58302763
82IKBKE0.57211825
83MAPK70.56578293
84NLK0.55927797
85CASK0.55389957
86CAMK2D0.55061306
87PDPK10.54120502
88CSNK1G10.54059578
89PTK20.53908551
90PRKCQ0.53903768
91EPHA30.53860580
92CAMK1G0.53549817
93NEK10.53141635
94IRAK30.52400671
95MAP3K130.52226193
96FGFR30.51881574
97YES10.51620773
98RET0.51146539
99CAMK2B0.48240105
100PRKCD0.47149923
101TAOK20.46419136
102MATK0.45540079
103IGF1R0.45346645
104SGK20.45225914
105MELK0.43041022
106PIM20.42670300
107MAP2K10.41439903
108SCYL20.41400711
109GRK10.41041594
110PDK10.41008644
111PRKCI0.39600739
112MAP3K60.38879185
113SRC0.38807840
114DDR20.38691707
115PBK0.37707349
116CSNK1G20.37598123
117MAP3K50.37557531
118ICK0.37398607
119CDK40.37172659
120PRKCG0.36738309
121FYN0.35369577
122CAMKK10.34487156
123CDC42BPA0.34438774
124MTOR0.34127427
125CSNK1G30.33548290
126CAMK40.32813771
127SGK4940.31849558
128SGK2230.31849558
129TESK10.31273849
130EGFR0.29736412
131MAPKAPK30.29694448
132PDK30.28707259
133PDK40.28707259
134PRKCA0.28093867
135MAPKAPK20.27568505
136NEK60.27355428
137CSNK1A1L0.26284952
138PIK3CA0.25707106
139PRKACA0.25408052
140BCR0.25195506
141IRAK20.25166148
142PRKG10.25118972
143MAP2K20.24566475
144TAOK10.22450376
145AURKB0.22396826
146AKT20.22356792
147MAP3K10.21568017
148PRKCE0.21126161
149FGFR10.20713928
150ABL10.20658983
151PRKCB0.20577256
152CDK90.19934581
153IRAK40.19738089
154BMPR1B0.18506003

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.30558175
2Nitrogen metabolism_Homo sapiens_hsa009103.59981078
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39423180
4* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35664742
5Arginine biosynthesis_Homo sapiens_hsa002203.04586512
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.01731976
7Tryptophan metabolism_Homo sapiens_hsa003802.70016515
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60345437
9Complement and coagulation cascades_Homo sapiens_hsa046102.55836477
10Fatty acid degradation_Homo sapiens_hsa000712.52336529
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47155505
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40707182
13* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19732018
14Butanoate metabolism_Homo sapiens_hsa006502.19598425
15* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16029651
16Peroxisome_Homo sapiens_hsa041462.07113472
17Propanoate metabolism_Homo sapiens_hsa006402.02534277
18* Chemical carcinogenesis_Homo sapiens_hsa052041.97793486
19Protein digestion and absorption_Homo sapiens_hsa049741.96828892
20Histidine metabolism_Homo sapiens_hsa003401.95556892
21* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94575573
22PPAR signaling pathway_Homo sapiens_hsa033201.91916947
23Fatty acid metabolism_Homo sapiens_hsa012121.90944041
24Mineral absorption_Homo sapiens_hsa049781.89422780
25* Steroid hormone biosynthesis_Homo sapiens_hsa001401.83819984
26Caffeine metabolism_Homo sapiens_hsa002321.81473341
27beta-Alanine metabolism_Homo sapiens_hsa004101.75902681
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73649560
29Staphylococcus aureus infection_Homo sapiens_hsa051501.72412246
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70522644
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68284812
32* Drug metabolism - other enzymes_Homo sapiens_hsa009831.66736544
33* Retinol metabolism_Homo sapiens_hsa008301.62799850
34Selenocompound metabolism_Homo sapiens_hsa004501.57626142
35Phenylalanine metabolism_Homo sapiens_hsa003601.56880228
36Bile secretion_Homo sapiens_hsa049761.54025970
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49349703
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49233876
39Pyruvate metabolism_Homo sapiens_hsa006201.46166106
40Fatty acid elongation_Homo sapiens_hsa000621.41860036
41Sulfur metabolism_Homo sapiens_hsa009201.41065644
42Tyrosine metabolism_Homo sapiens_hsa003501.39447347
43Steroid biosynthesis_Homo sapiens_hsa001001.37080716
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.28827524
45ABC transporters_Homo sapiens_hsa020101.22010750
46Biosynthesis of amino acids_Homo sapiens_hsa012301.20459886
47Fat digestion and absorption_Homo sapiens_hsa049751.18411994
48* Starch and sucrose metabolism_Homo sapiens_hsa005001.18314048
49Folate biosynthesis_Homo sapiens_hsa007901.17693452
50Carbon metabolism_Homo sapiens_hsa012001.16361581
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04446624
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.04284970
53Arginine and proline metabolism_Homo sapiens_hsa003300.99936292
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99310822
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.97475297
56Sulfur relay system_Homo sapiens_hsa041220.88216317
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87322930
58Vitamin digestion and absorption_Homo sapiens_hsa049770.85069897
59Lysine degradation_Homo sapiens_hsa003100.84277975
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84095790
61* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80339110
62One carbon pool by folate_Homo sapiens_hsa006700.75286416
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74769419
64Glycerolipid metabolism_Homo sapiens_hsa005610.73799477
65Vitamin B6 metabolism_Homo sapiens_hsa007500.70827182
66Fatty acid biosynthesis_Homo sapiens_hsa000610.66353885
67Glutathione metabolism_Homo sapiens_hsa004800.65170157
68Sphingolipid metabolism_Homo sapiens_hsa006000.62522284
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62089541
70Pentose phosphate pathway_Homo sapiens_hsa000300.60196774
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51580179
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47253152
73* Metabolic pathways_Homo sapiens_hsa011000.46113563
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30410876
75Galactose metabolism_Homo sapiens_hsa000520.27470218
76Pancreatic secretion_Homo sapiens_hsa049720.26695481
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26377946
78Fructose and mannose metabolism_Homo sapiens_hsa000510.26070671
79Linoleic acid metabolism_Homo sapiens_hsa005910.25129976
80Insulin resistance_Homo sapiens_hsa049310.23820999
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.23673349
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.16400818
83Prion diseases_Homo sapiens_hsa050200.13010187
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10732923
85Glucagon signaling pathway_Homo sapiens_hsa049220.10405497
86Serotonergic synapse_Homo sapiens_hsa047260.08874052
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05739174
88Renin secretion_Homo sapiens_hsa049240.04457691
89AMPK signaling pathway_Homo sapiens_hsa041520.02854447
90Tight junction_Homo sapiens_hsa045300.01616405
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2527485
92Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2466296
93Ether lipid metabolism_Homo sapiens_hsa00565-0.2432864
94Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2353831
95Type II diabetes mellitus_Homo sapiens_hsa04930-0.2335333
96Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2301640
97Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2093742
98Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2032502
99Hepatitis C_Homo sapiens_hsa05160-0.2027389
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1803489
101Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1753446
102Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1635846
103Renin-angiotensin system_Homo sapiens_hsa04614-0.1618993
104Pertussis_Homo sapiens_hsa05133-0.1576357
105Regulation of autophagy_Homo sapiens_hsa04140-0.1549336
106Amoebiasis_Homo sapiens_hsa05146-0.1491118
107Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1442780
108African trypanosomiasis_Homo sapiens_hsa05143-0.1339520
109N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1147761
110Thyroid cancer_Homo sapiens_hsa05216-0.1129410
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1114264
112Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.1107040
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0983944
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0871917
115Insulin signaling pathway_Homo sapiens_hsa04910-0.0836350
116Cocaine addiction_Homo sapiens_hsa05030-0.0718062
117Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0550059
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0171909
119Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0030605

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