ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	doxorubicin metabolic process (GO:0044598)	9.95518140
2	daunorubicin metabolic process (GO:0044597)	9.95518140
3	polyketide metabolic process (GO:0030638)	9.95518140
4	aminoglycoside antibiotic metabolic process (GO:0030647)	8.90194580
5	* cellular glucuronidation (GO:0052695)	8.15311779
6	* glucuronate metabolic process (GO:0019585)	7.64614235
7	* uronic acid metabolic process (GO:0006063)	7.64614235
8	exogenous drug catabolic process (GO:0042738)	7.41922671
9	negative regulation of fibrinolysis (GO:0051918)	7.04716128
10	drug catabolic process (GO:0042737)	6.77069724
11	regulation of fibrinolysis (GO:0051917)	6.68135512
12	epoxygenase P450 pathway (GO:0019373)	6.68086585
13	L-phenylalanine catabolic process (GO:0006559)	6.64450092
14	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.64450092
15	L-phenylalanine metabolic process (GO:0006558)	6.54056472
16	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.54056472
17	regulation of protein activation cascade (GO:2000257)	6.39994093
18	urea metabolic process (GO:0019627)	6.34360558
19	complement activation, alternative pathway (GO:0006957)	6.19445612
20	omega-hydroxylase P450 pathway (GO:0097267)	6.10978724
21	glyoxylate metabolic process (GO:0046487)	6.04464167
22	regulation of complement activation (GO:0030449)	5.95429791
23	flavonoid metabolic process (GO:0009812)	5.90391190
24	nitrogen cycle metabolic process (GO:0071941)	5.71556890
25	fibrinolysis (GO:0042730)	5.67387243
26	primary alcohol catabolic process (GO:0034310)	5.44225177
27	urea cycle (GO:0000050)	5.41627926
28	drug metabolic process (GO:0017144)	5.25437730
29	phenylpropanoid metabolic process (GO:0009698)	5.05463892
30	glycoside metabolic process (GO:0016137)	5.00526209
31	bile acid and bile salt transport (GO:0015721)	4.93296067
32	bile acid metabolic process (GO:0008206)	4.90915731
33	protein carboxylation (GO:0018214)	4.83621080
34	peptidyl-glutamic acid carboxylation (GO:0017187)	4.83621080
35	intestinal cholesterol absorption (GO:0030299)	4.81183439
36	ethanol oxidation (GO:0006069)	4.80272788
37	bile acid biosynthetic process (GO:0006699)	4.72560938
38	negative regulation of cholesterol transport (GO:0032375)	4.67603394
39	negative regulation of sterol transport (GO:0032372)	4.67603394
40	aromatic amino acid family catabolic process (GO:0009074)	4.60442412
41	drug transmembrane transport (GO:0006855)	4.58561783
42	blood coagulation, intrinsic pathway (GO:0007597)	4.53050686
43	amino-acid betaine metabolic process (GO:0006577)	4.42249535
44	retinal metabolic process (GO:0042574)	4.29209878
45	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.28019588
46	hormone catabolic process (GO:0042447)	4.27215871
47	negative regulation of hemostasis (GO:1900047)	4.26192317
48	negative regulation of blood coagulation (GO:0030195)	4.26192317
49	xenobiotic catabolic process (GO:0042178)	4.15471771
50	serine family amino acid catabolic process (GO:0009071)	4.12249137
51	regulation of plasminogen activation (GO:0010755)	4.07104217
52	negative regulation of lipase activity (GO:0060192)	4.06651257
53	oxidative demethylation (GO:0070989)	4.04884056
54	glycine metabolic process (GO:0006544)	4.01932926
55	ethanol metabolic process (GO:0006067)	4.00501694
56	negative regulation of coagulation (GO:0050819)	3.92694657
57	protein activation cascade (GO:0072376)	3.91984228
58	quinone metabolic process (GO:1901661)	3.90900587
59	negative regulation of wound healing (GO:0061045)	3.90027493
60	progesterone metabolic process (GO:0042448)	3.85901524
61	drug transport (GO:0015893)	3.82598083
62	phospholipid efflux (GO:0033700)	3.77313412
63	negative regulation of protein activation cascade (GO:2000258)	3.75543567
64	cysteine metabolic process (GO:0006534)	3.69814409
65	complement activation, classical pathway (GO:0006958)	3.66398944
66	acute-phase response (GO:0006953)	3.66138197
67	regulation of humoral immune response (GO:0002920)	3.64912157
68	complement activation (GO:0006956)	3.62692425
69	response to mercury ion (GO:0046689)	3.62465194
70	S-adenosylmethionine metabolic process (GO:0046500)	3.61119985
71	positive regulation of hemostasis (GO:1900048)	3.57513691
72	positive regulation of blood coagulation (GO:0030194)	3.57513691
73	regulation of triglyceride catabolic process (GO:0010896)	3.54376770
74	heme transport (GO:0015886)	3.53097160
75	acylglycerol homeostasis (GO:0055090)	3.50963801
76	triglyceride homeostasis (GO:0070328)	3.50963801
77	phosphate ion transmembrane transport (GO:0035435)	3.49879054
78	serine family amino acid metabolic process (GO:0009069)	3.49440505
79	* xenobiotic metabolic process (GO:0006805)	3.47574218
80	tyrosine metabolic process (GO:0006570)	3.45717969
81	coenzyme catabolic process (GO:0009109)	3.44011578
82	cellular aldehyde metabolic process (GO:0006081)	3.42641723
83	arginine metabolic process (GO:0006525)	3.40897429
84	C21-steroid hormone metabolic process (GO:0008207)	3.34920109
85	retinoic acid metabolic process (GO:0042573)	3.34202726
86	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.33979539
87	regulation of cholesterol esterification (GO:0010872)	3.33478464
88	positive regulation of coagulation (GO:0050820)	3.32257977
89	citrulline biosynthetic process (GO:0019240)	3.31803907
90	cofactor catabolic process (GO:0051187)	3.29060120
91	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.26844079
92	very-low-density lipoprotein particle assembly (GO:0034379)	3.25476060
93	primary alcohol metabolic process (GO:0034308)	3.25015350
94	glutamate metabolic process (GO:0006536)	3.22552672
95	response to nitrosative stress (GO:0051409)	3.21890829
96	urate metabolic process (GO:0046415)	3.18784840
97	negative regulation of fatty acid metabolic process (GO:0045922)	3.13761950
98	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.13412233
99	regulation of apoptotic cell clearance (GO:2000425)	3.13380943
100	high-density lipoprotein particle remodeling (GO:0034375)	3.12574548

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	8.40747745
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	5.48745898
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	4.74653701
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	4.60261185
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.39650059
6	LXR_22158963_ChIP-Seq_LIVER_Mouse	4.37206950
7	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.91671697
8	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.77269891
9	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.64876090
10	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.53648360
11	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.18198807
12	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.84615542
13	* SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.60234290
14	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.48881643
15	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.36799474
16	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.26660825
17	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.23228225
18	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.21000770
19	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.09946033
20	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.04374732
21	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.97561945
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.96981648
23	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.88597367
24	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.85581797
25	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.85129250
26	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.84389916
27	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.78893781
28	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.77364155
29	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.75849486
30	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.72120626
31	GATA6_25053715_ChIP-Seq_YYC3_Human	1.69197900
32	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.66471672
33	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.58033172
34	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.57929074
35	* SOX2_20726797_ChIP-Seq_SW620_Human	1.50416082
36	* RACK7_27058665_Chip-Seq_MCF-7_Human	1.47812426
37	* GATA4_25053715_ChIP-Seq_YYC3_Human	1.47275403
38	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.46522303
39	* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.46250514
40	* SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.44378927
41	* SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.44378927
42	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.39829397
43	CLOCK_20551151_ChIP-Seq_293T_Human	1.39633503
44	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.38630807
45	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.33117292
46	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.28505299
47	ZNF263_19887448_ChIP-Seq_K562_Human	1.28155589
48	LXR_22292898_ChIP-Seq_THP-1_Human	1.26206308
49	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.22605820
50	* GATA3_24758297_ChIP-Seq_MCF-7_Human	1.22523098
51	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.19011327
52	AR_21909140_ChIP-Seq_LNCAP_Human	1.17092982
53	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.16290090
54	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.13353855
55	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.09459577
56	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.09370333
57	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.08208169
58	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.06726316
59	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.02533718
60	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.02302926
61	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.01878807
62	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.99890187
63	SMC4_20622854_ChIP-Seq_HELA_Human	0.96930877
64	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.96634520
65	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.95149896
66	AHR_22903824_ChIP-Seq_MCF-7_Human	0.90739026
67	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.90493475
68	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.89895606
69	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.89181936
70	ATF3_27146783_Chip-Seq_COLON_Human	0.88505614
71	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.88397532
72	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.82397085
73	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.79148814
74	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.78842153
75	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.78110178
76	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.77120585
77	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.75255754
78	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.74137929
79	CJUN_26792858_Chip-Seq_BT549_Human	0.73714431
80	KLF5_25053715_ChIP-Seq_YYC3_Human	0.73280493
81	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.71804146
82	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.70765722
83	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.70324755
84	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.69707001
85	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.68996008
86	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.68942061
87	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.68527782
88	TP53_18474530_ChIP-ChIP_U2OS_Human	0.68127277
89	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.67441851
90	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.64119482
91	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.64048144
92	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.63172458
93	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.63040515
94	* TP63_22573176_ChIP-Seq_HFKS_Human	0.61726369
95	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.61617499
96	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.60898271
97	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.59017120
98	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.58597541
99	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.58281313
100	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.57960625

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.87114647
2	MP0005365_abnormal_bile_salt	5.65459511
3	MP0008875_abnormal_xenobiotic_pharmacok	5.61819698
4	MP0005085_abnormal_gallbladder_physiolo	5.49019719
5	MP0005360_urolithiasis	5.21586274
6	MP0002138_abnormal_hepatobiliary_system	4.39345379
7	MP0003252_abnormal_bile_duct	4.21104123
8	MP0003195_calcinosis	3.26810104
9	MP0003868_abnormal_feces_composition	3.17760460
10	MP0001666_abnormal_nutrient_absorption	3.08483281
11	MP0003806_abnormal_nucleotide_metabolis	2.74196613
12	MP0005332_abnormal_amino_acid	2.43984219
13	MP0003191_abnormal_cellular_cholesterol	2.18042608
14	MP0009840_abnormal_foam_cell	2.16523034
15	MP0010329_abnormal_lipoprotein_level	2.15205781
16	MP0009697_abnormal_copulation	2.00870044
17	MP0009053_abnormal_anal_canal	1.90965663
18	MP0000609_abnormal_liver_physiology	1.71558655
19	MP0004019_abnormal_vitamin_homeostasis	1.71530462
20	MP0010234_abnormal_vibrissa_follicle	1.64076749
21	MP0005451_abnormal_body_composition	1.60439493
22	MP0003705_abnormal_hypodermis_morpholog	1.44190053
23	MP0002118_abnormal_lipid_homeostasis	1.43880887
24	MP0005408_hypopigmentation	1.40104866
25	MP0009643_abnormal_urine_homeostasis	1.33496529
26	MP0005023_abnormal_wound_healing	1.27571136
27	MP0005319_abnormal_enzyme/_coenzyme	1.20862627
28	MP0001661_extended_life_span	1.20068377
29	MP0005584_abnormal_enzyme/coenzyme_acti	1.14094215
30	MP0010386_abnormal_urinary_bladder	1.10950538
31	MP0003186_abnormal_redox_activity	1.10192233
32	MP0002796_impaired_skin_barrier	1.10012602
33	MP0002876_abnormal_thyroid_physiology	1.06538431
34	MP0001764_abnormal_homeostasis	1.05177528
35	MP0000467_abnormal_esophagus_morphology	1.04993010
36	MP0003566_abnormal_cell_adhesion	1.02419080
37	MP0003656_abnormal_erythrocyte_physiolo	0.96368986
38	MP0003453_abnormal_keratinocyte_physiol	0.95822383
39	MP0003879_abnormal_hair_cell	0.94438024
40	MP0010368_abnormal_lymphatic_system	0.91226458
41	MP0000598_abnormal_liver_morphology	0.90878907
42	MP0001756_abnormal_urination	0.90226864
43	MP0003638_abnormal_response/metabolism_	0.89792229
44	MP0005058_abnormal_lysosome_morphology	0.89451659
45	MP0004782_abnormal_surfactant_physiolog	0.87756463
46	MP0001348_abnormal_lacrimal_gland	0.86081975
47	MP0000566_synostosis	0.85414587
48	MP0005670_abnormal_white_adipose	0.76599014
49	MP0004272_abnormal_basement_membrane	0.74792340
50	MP0009642_abnormal_blood_homeostasis	0.74588117
51	MP0002136_abnormal_kidney_physiology	0.72088524
52	MP0002098_abnormal_vibrissa_morphology	0.71790662
53	MP0005501_abnormal_skin_physiology	0.71190127
54	MP0001915_intracranial_hemorrhage	0.70861411
55	MP0001851_eye_inflammation	0.70169845
56	MP0005376_homeostasis/metabolism_phenot	0.69322527
57	MP0010678_abnormal_skin_adnexa	0.69066010
58	MP0004264_abnormal_extraembryonic_tissu	0.68908157
59	MP0005636_abnormal_mineral_homeostasis	0.68906718
60	MP0002249_abnormal_larynx_morphology	0.68412470
61	MP0008469_abnormal_protein_level	0.66728236
62	MP0003941_abnormal_skin_development	0.64515693
63	MP0005164_abnormal_response_to	0.62251969
64	MP0009763_increased_sensitivity_to	0.61108021
65	MP0002060_abnormal_skin_morphology	0.59434581
66	MP0003690_abnormal_glial_cell	0.59423754
67	MP0002909_abnormal_adrenal_gland	0.59138055
68	MP0005187_abnormal_penis_morphology	0.58540161
69	MP0003878_abnormal_ear_physiology	0.57460493
70	MP0005377_hearing/vestibular/ear_phenot	0.57460493
71	MP0000003_abnormal_adipose_tissue	0.57024536
72	MP0000604_amyloidosis	0.56469772
73	MP0005076_abnormal_cell_differentiation	0.56422378
74	MP0005464_abnormal_platelet_physiology	0.56310764
75	MP0005395_other_phenotype	0.56148911
76	MP0002168_other_aberrant_phenotype	0.55569698
77	MP0000858_altered_metastatic_potential	0.55046162
78	MP0001216_abnormal_epidermal_layer	0.54765255
79	MP0000579_abnormal_nail_morphology	0.54203024
80	MP0002971_abnormal_brown_adipose	0.53785312
81	MP0005197_abnormal_uvea_morphology	0.53263778
82	MP0002132_abnormal_respiratory_system	0.52150506
83	MP0003011_delayed_dark_adaptation	0.51955101
84	MP0000627_abnormal_mammary_gland	0.51663399
85	MP0000516_abnormal_urinary_system	0.50941575
86	MP0005367_renal/urinary_system_phenotyp	0.50941575
87	MP0009780_abnormal_chondrocyte_physiolo	0.50724493
88	MP0002928_abnormal_bile_duct	0.49561210
89	MP0008874_decreased_physiological_sensi	0.47590978
90	MP0003183_abnormal_peptide_metabolism	0.47239540
91	MP0000534_abnormal_ureter_morphology	0.46700607
92	MP0005248_abnormal_Harderian_gland	0.45169941
93	MP0005257_abnormal_intraocular_pressure	0.44931940
94	MP0001881_abnormal_mammary_gland	0.43493078
95	MP0005409_darkened_coat_color	0.42958944
96	MP0002697_abnormal_eye_size	0.42819856
97	MP0004233_abnormal_muscle_weight	0.42763942
98	MP0001849_ear_inflammation	0.39612958
99	MP0000249_abnormal_blood_vessel	0.39525499
100	MP0005083_abnormal_biliary_tract	0.38811385

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of monocarboxylic acid metabolism (HP:0010996)	9.69822034
2	Deep venous thrombosis (HP:0002625)	8.20533469
3	Complement deficiency (HP:0004431)	7.64783226
4	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.02452575
5	Hypobetalipoproteinemia (HP:0003563)	6.94893842
6	Conjugated hyperbilirubinemia (HP:0002908)	6.93852806
7	Prolonged partial thromboplastin time (HP:0003645)	6.69204661
8	Abnormality of complement system (HP:0005339)	6.48828433
9	Abnormality of the common coagulation pathway (HP:0010990)	5.41995279
10	Intrahepatic cholestasis (HP:0001406)	5.14531665
11	Systemic lupus erythematosus (HP:0002725)	5.11349894
12	Glomerulonephritis (HP:0000099)	5.06283725
13	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.22376733
14	Joint hemorrhage (HP:0005261)	4.18467917
15	Spontaneous abortion (HP:0005268)	4.13738107
16	Hypolipoproteinemia (HP:0010981)	4.10358057
17	Abnormality of pyrimidine metabolism (HP:0004353)	4.09692310
18	Fat malabsorption (HP:0002630)	4.08277256
19	Nephritis (HP:0000123)	4.02608151
20	Xanthomatosis (HP:0000991)	3.84519895
21	Rickets (HP:0002748)	3.58012221
22	Vascular calcification (HP:0004934)	3.45429922
23	Steatorrhea (HP:0002570)	3.42015739
24	Hyperlipoproteinemia (HP:0010980)	3.38811763
25	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.30244845
26	Mitral stenosis (HP:0001718)	3.16574626
27	Abnormality of the intrinsic pathway (HP:0010989)	3.13369045
28	Hyperammonemia (HP:0001987)	3.10286767
29	Generalized aminoaciduria (HP:0002909)	3.05812477
30	Hypercholesterolemia (HP:0003124)	3.04856050
31	Cardiovascular calcification (HP:0011915)	3.01659012
32	Hemorrhage of the eye (HP:0011885)	2.98554954
33	Focal segmental glomerulosclerosis (HP:0000097)	2.93291397
34	Hyperbilirubinemia (HP:0002904)	2.83296281
35	Recurrent gram-negative bacterial infections (HP:0005420)	2.81393696
36	Osteomalacia (HP:0002749)	2.76079211
37	Gingival bleeding (HP:0000225)	2.75843650
38	Abnormality of nucleobase metabolism (HP:0010932)	2.69641552
39	Abnormality of the Achilles tendon (HP:0005109)	2.66091687
40	Abnormality of methionine metabolism (HP:0010901)	2.60609500
41	Hepatocellular carcinoma (HP:0001402)	2.58341787
42	Glomerulosclerosis (HP:0000096)	2.58004636
43	Abnormality of proline metabolism (HP:0010907)	2.39413593
44	Hydroxyprolinuria (HP:0003080)	2.39413593
45	Gout (HP:0001997)	2.37233172
46	Abnormal gallbladder physiology (HP:0012438)	2.36120014
47	Cholecystitis (HP:0001082)	2.36120014
48	Hypoalphalipoproteinemia (HP:0003233)	2.31564111
49	Facial shape deformation (HP:0011334)	2.27279338
50	Potter facies (HP:0002009)	2.27279338
51	Purpura (HP:0000979)	2.26432591
52	Abnormality of vitamin metabolism (HP:0100508)	2.25452895
53	Increased serum ferritin (HP:0003281)	2.24173280
54	Hyperglycinuria (HP:0003108)	2.23985240
55	Cerebral palsy (HP:0100021)	2.16136527
56	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.14815698
57	Bifid scrotum (HP:0000048)	2.13941775
58	Cholelithiasis (HP:0001081)	2.13660713
59	Abnormality of glycine metabolism (HP:0010895)	2.11361266
60	Abnormality of serine family amino acid metabolism (HP:0010894)	2.11361266
61	Back pain (HP:0003418)	2.11276586
62	Elevated alkaline phosphatase (HP:0003155)	2.10540882
63	Hyperglycinemia (HP:0002154)	2.10007708
64	Reduced antithrombin III activity (HP:0001976)	2.07617324
65	Abnormal enzyme/coenzyme activity (HP:0012379)	2.05667368
66	Abnormality of purine metabolism (HP:0004352)	2.05451622
67	Menorrhagia (HP:0000132)	2.04165633
68	Abnormality of alkaline phosphatase activity (HP:0004379)	2.02150828
69	Joint swelling (HP:0001386)	1.99208506
70	Increased mean platelet volume (HP:0011877)	1.99102755
71	Reticulocytosis (HP:0001923)	1.98237778
72	Nuclear cataract (HP:0100018)	1.96637265
73	Abnormal gallbladder morphology (HP:0012437)	1.96265856
74	Abnormality of iron homeostasis (HP:0011031)	1.95821876
75	Thrombophlebitis (HP:0004418)	1.92446307
76	Hyperphosphaturia (HP:0003109)	1.91957054
77	Abnormality of urine glucose concentration (HP:0011016)	1.91639151
78	Glycosuria (HP:0003076)	1.91639151
79	Delayed CNS myelination (HP:0002188)	1.91415659
80	Abnormality of serum amino acid levels (HP:0003112)	1.84708490
81	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.77899360
82	Epidermoid cyst (HP:0200040)	1.77862856
83	Esophageal varix (HP:0002040)	1.77201934
84	Abnormal urine phosphate concentration (HP:0012599)	1.74469507
85	Abnormality of transition element cation homeostasis (HP:0011030)	1.73740478
86	Abdominal distention (HP:0003270)	1.73463648
87	Hypophosphatemic rickets (HP:0004912)	1.73183375
88	Metabolic acidosis (HP:0001942)	1.70935626
89	Abnormality of the gastric mucosa (HP:0004295)	1.70106301
90	Sex reversal (HP:0012245)	1.69798355
91	Abnormal sex determination (HP:0012244)	1.69798355
92	Abnormal platelet volume (HP:0011876)	1.69523111
93	Irritability (HP:0000737)	1.69031847
94	Myocardial infarction (HP:0001658)	1.68931169
95	Increased purine levels (HP:0004368)	1.66675163
96	Hyperuricemia (HP:0002149)	1.66675163
97	Abnormality of fatty-acid metabolism (HP:0004359)	1.66335423
98	Polygenic inheritance (HP:0010982)	1.65005326
99	Abnormal hair laboratory examination (HP:0003328)	1.63429132
100	Periodontitis (HP:0000704)	1.62614527

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	6.24326500
2	IRAK3	4.59502600
3	EPHA2	4.51818291
4	MET	3.29702890
5	ERN1	2.75628440
6	MAP3K2	2.64441095
7	ERBB4	2.53482137
8	SIK1	2.45900898
9	SMG1	2.44095599
10	RIPK1	2.31564071
11	TRIB3	2.27280388
12	MAP3K3	2.26239652
13	MAP3K12	2.11745771
14	STK38	1.80918246
15	FGFR4	1.79260906
16	SCYL2	1.74206949
17	PTK2	1.67107081
18	RPS6KB2	1.67080620
19	PAK4	1.66471471
20	PBK	1.66029151
21	MAP3K9	1.63554547
22	MAP2K6	1.63382913
23	LATS1	1.55046357
24	LATS2	1.44339363
25	MAPKAPK3	1.40487649
26	EIF2AK1	1.27919733
27	ICK	1.27134884
28	TESK1	1.24957014
29	PDGFRA	1.23794076
30	EPHB1	1.23762025
31	ARAF	1.22496818
32	TBK1	1.11117303
33	NTRK1	1.10418717
34	PTK6	1.01539765
35	NEK1	0.99899645
36	PIK3CA	0.96507862
37	IRAK2	0.95168696
38	MYLK	0.91054324
39	NME2	0.83548955
40	CAMK2G	0.81907402
41	MAPK11	0.81811390
42	CDK8	0.81214594
43	FER	0.78697844
44	CDK9	0.78548282
45	NEK9	0.76839670
46	TTN	0.76581700
47	PDPK1	0.74688717
48	PKN2	0.73329840
49	IRAK1	0.72765031
50	STK38L	0.71409487
51	PRKAA2	0.70852254
52	MAP3K6	0.70776178
53	MAP3K1	0.70482520
54	PIK3CG	0.69936089
55	KSR2	0.68289052
56	MAP3K13	0.64862676
57	NEK6	0.64040202
58	CDK12	0.63165543
59	MAP2K2	0.61424163
60	MTOR	0.60516853
61	BRSK2	0.59874870
62	ABL2	0.58735632
63	MAP2K1	0.58317846
64	TYK2	0.55823908
65	FGFR3	0.55727282
66	CAMK2B	0.55375680
67	MST4	0.52870007
68	PRKCI	0.52785127
69	TRPM7	0.52745328
70	IGF1R	0.52416354
71	LRRK2	0.49227630
72	PRKG2	0.47433203
73	CDK6	0.46865452
74	IRAK4	0.46432206
75	EPHA3	0.45794219
76	MAP3K8	0.44881054
77	MAP2K4	0.44542780
78	CSF1R	0.43159412
79	FLT3	0.41898097
80	MELK	0.38112544
81	PRKACG	0.37887442
82	MAPK15	0.37825483
83	MAP3K7	0.37655781
84	PRKCZ	0.34255922
85	BCKDK	0.33865279
86	DAPK1	0.33701799
87	ERBB2	0.33506730
88	CDK7	0.30150894
89	ZAP70	0.30084023
90	CAMK2D	0.28030478
91	JAK1	0.27859016
92	RET	0.27055136
93	BMX	0.26463365
94	MUSK	0.26028029
95	CDK4	0.25284944
96	SRC	0.24176953
97	YES1	0.23857062
98	LMTK2	0.22795807
99	SGK3	0.22379719
100	GSK3A	0.22201001

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	4.44983824
2	* Pentose and glucuronate interconversions_Homo sapiens_hsa00040	3.79716346
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.46649641
4	* Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.46593227
5	Caffeine metabolism_Homo sapiens_hsa00232	3.35577574
6	* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.34508278
7	* Steroid hormone biosynthesis_Homo sapiens_hsa00140	3.26145097
8	* Retinol metabolism_Homo sapiens_hsa00830	3.23666060
9	Complement and coagulation cascades_Homo sapiens_hsa04610	3.21848121
10	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.19780020
11	* Chemical carcinogenesis_Homo sapiens_hsa05204	3.17646208
12	* Drug metabolism - other enzymes_Homo sapiens_hsa00983	3.10308489
13	Phenylalanine metabolism_Homo sapiens_hsa00360	2.48838003
14	* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.23987579
15	Arginine biosynthesis_Homo sapiens_hsa00220	2.21070686
16	Tyrosine metabolism_Homo sapiens_hsa00350	2.04707198
17	Fatty acid degradation_Homo sapiens_hsa00071	2.04259733
18	Histidine metabolism_Homo sapiens_hsa00340	2.03698471
19	* Starch and sucrose metabolism_Homo sapiens_hsa00500	2.02544193
20	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.98354849
21	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.96573227
22	Bile secretion_Homo sapiens_hsa04976	1.83810439
23	Butanoate metabolism_Homo sapiens_hsa00650	1.83425676
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.75147623
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.74445436
26	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.43697033
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38566053
28	beta-Alanine metabolism_Homo sapiens_hsa00410	1.38558365
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.35032993
30	PPAR signaling pathway_Homo sapiens_hsa03320	1.20035723
31	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.19491332
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.18412545
33	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.16737371
34	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.07465052
35	Carbon metabolism_Homo sapiens_hsa01200	1.07267684
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.06364546
37	Peroxisome_Homo sapiens_hsa04146	1.05200414
38	Arginine and proline metabolism_Homo sapiens_hsa00330	0.99864628
39	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.99335061
40	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.98722931
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.96004729
42	Pyruvate metabolism_Homo sapiens_hsa00620	0.93520170
43	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.89876516
44	Pentose phosphate pathway_Homo sapiens_hsa00030	0.86041017
45	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.85357841
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.84175475
47	Fatty acid metabolism_Homo sapiens_hsa01212	0.82307358
48	Galactose metabolism_Homo sapiens_hsa00052	0.81019277
49	ABC transporters_Homo sapiens_hsa02010	0.77692426
50	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.76589564
51	Glutathione metabolism_Homo sapiens_hsa00480	0.75848962
52	Prion diseases_Homo sapiens_hsa05020	0.74249667
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.72904828
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72332869
55	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.70079496
56	Propanoate metabolism_Homo sapiens_hsa00640	0.67947524
57	One carbon pool by folate_Homo sapiens_hsa00670	0.59692696
58	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.59376914
59	Lysine degradation_Homo sapiens_hsa00310	0.53643477
60	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.47070951
61	* Metabolic pathways_Homo sapiens_hsa01100	0.41012502
62	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.38609140
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38101481
64	Sulfur metabolism_Homo sapiens_hsa00920	0.33235233
65	Folate biosynthesis_Homo sapiens_hsa00790	0.28495749
66	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.27663707
67	Sulfur relay system_Homo sapiens_hsa04122	0.22431647
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.21800793
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.21474304
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.17974621
71	Fatty acid elongation_Homo sapiens_hsa00062	0.17717770
72	Other glycan degradation_Homo sapiens_hsa00511	0.16028561
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.15936921
74	Pertussis_Homo sapiens_hsa05133	0.15928648
75	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.11711688
76	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.10943107
77	Insulin resistance_Homo sapiens_hsa04931	0.09696061
78	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.09144873
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.08781092
80	Sphingolipid metabolism_Homo sapiens_hsa00600	0.08308741
81	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.06798442
82	Thyroid cancer_Homo sapiens_hsa05216	0.06445272
83	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.04531863
84	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.03430875
85	Renin-angiotensin system_Homo sapiens_hsa04614	0.02468609
86	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.00710377
87	ECM-receptor interaction_Homo sapiens_hsa04512	0.00149533
88	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.1407453
89	Hepatitis C_Homo sapiens_hsa05160	-0.1288016
90	Renal cell carcinoma_Homo sapiens_hsa05211	-0.1269910
91	Nitrogen metabolism_Homo sapiens_hsa00910	-0.1165000
92	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1156346
93	Ether lipid metabolism_Homo sapiens_hsa00565	-0.1156050
94	Small cell lung cancer_Homo sapiens_hsa05222	-0.1144300
95	Bladder cancer_Homo sapiens_hsa05219	-0.0740331
96	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0399731
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.0263984
98	Amoebiasis_Homo sapiens_hsa05146	-0.0238234
99	Glucagon signaling pathway_Homo sapiens_hsa04922	-0.0213111
100	Steroid biosynthesis_Homo sapiens_hsa00100	-0.0205885

UGT1A6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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