ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	daunorubicin metabolic process (GO:0044597)	8.25548297
2	polyketide metabolic process (GO:0030638)	8.25548297
3	doxorubicin metabolic process (GO:0044598)	8.25548297
4	aminoglycoside antibiotic metabolic process (GO:0030647)	7.31675693
5	primary alcohol catabolic process (GO:0034310)	5.87740909
6	keratinization (GO:0031424)	5.13372515
7	tachykinin receptor signaling pathway (GO:0007217)	5.01159402
8	coenzyme catabolic process (GO:0009109)	4.91002089
9	establishment of skin barrier (GO:0061436)	4.88617566
10	desmosome organization (GO:0002934)	4.73883228
11	* flavonoid metabolic process (GO:0009812)	4.54148241
12	keratinocyte differentiation (GO:0030216)	4.46618009
13	fat-soluble vitamin catabolic process (GO:0042363)	4.45603803
14	vitamin catabolic process (GO:0009111)	4.45603803
15	quinone metabolic process (GO:1901661)	4.43247175
16	lateral sprouting from an epithelium (GO:0060601)	4.26127525
17	smooth muscle tissue development (GO:0048745)	4.19921594
18	transepithelial transport (GO:0070633)	4.13187173
19	intestinal epithelial cell development (GO:0060576)	4.10098971
20	* cellular glucuronidation (GO:0052695)	4.09046179
21	positive regulation of digestive system process (GO:0060456)	4.08391226
22	keratinocyte proliferation (GO:0043616)	4.02967059
23	* uronic acid metabolic process (GO:0006063)	3.94983064
24	* glucuronate metabolic process (GO:0019585)	3.94983064
25	regulation of water loss via skin (GO:0033561)	3.79865420
26	positive regulation of amino acid transport (GO:0051957)	3.76318667
27	cofactor catabolic process (GO:0051187)	3.70011041
28	keratinocyte development (GO:0003334)	3.69019651
29	establishment of tissue polarity (GO:0007164)	3.66692415
30	establishment of planar polarity (GO:0001736)	3.66692415
31	response to nitrosative stress (GO:0051409)	3.65509266
32	response to pheromone (GO:0019236)	3.58118878
33	xenobiotic catabolic process (GO:0042178)	3.55474334
34	regulation of keratinocyte proliferation (GO:0010837)	3.55101497
35	peptide cross-linking (GO:0018149)	3.47909728
36	dopamine transport (GO:0015872)	3.35612663
37	epidermal cell differentiation (GO:0009913)	3.34475305
38	retinal metabolic process (GO:0042574)	3.30894797
39	negative regulation of keratinocyte proliferation (GO:0010839)	3.28136914
40	neural tube formation (GO:0001841)	3.26223564
41	indole-containing compound catabolic process (GO:0042436)	3.25571741
42	indolalkylamine catabolic process (GO:0046218)	3.25571741
43	tryptophan catabolic process (GO:0006569)	3.25571741
44	kynurenine metabolic process (GO:0070189)	3.24408822
45	glycoside metabolic process (GO:0016137)	3.23292898
46	detection of light stimulus involved in visual perception (GO:0050908)	3.22946454
47	detection of light stimulus involved in sensory perception (GO:0050962)	3.22946454
48	* retinoic acid metabolic process (GO:0042573)	3.22246815
49	polarized epithelial cell differentiation (GO:0030859)	3.21212530
50	sympathetic nervous system development (GO:0048485)	3.20047341
51	ethanol oxidation (GO:0006069)	3.16812483
52	indolalkylamine metabolic process (GO:0006586)	3.13310328
53	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.07716144
54	negative regulation of neurotransmitter transport (GO:0051589)	3.01095627
55	benzene-containing compound metabolic process (GO:0042537)	3.00499910
56	tryptophan metabolic process (GO:0006568)	2.99805362
57	negative regulation of neurotransmitter secretion (GO:0046929)	2.99268616
58	DNA double-strand break processing (GO:0000729)	2.99224703
59	L-fucose catabolic process (GO:0042355)	2.96008624
60	fucose catabolic process (GO:0019317)	2.96008624
61	L-fucose metabolic process (GO:0042354)	2.96008624
62	platelet dense granule organization (GO:0060155)	2.94270081
63	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.94173981
64	ethanol metabolic process (GO:0006067)	2.92045952
65	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.88917268
66	regulation of mesoderm development (GO:2000380)	2.87385486
67	branched-chain amino acid catabolic process (GO:0009083)	2.86588803
68	complement activation, classical pathway (GO:0006958)	2.86089410
69	regulation of memory T cell differentiation (GO:0043380)	2.84482182
70	protein K11-linked deubiquitination (GO:0035871)	2.83659770
71	cellular ketone metabolic process (GO:0042180)	2.83442715
72	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.81480450
73	molting cycle (GO:0042303)	2.81178072
74	hair cycle (GO:0042633)	2.81178072
75	negative regulation of epidermal cell differentiation (GO:0045605)	2.78533956
76	regulation of phospholipase A2 activity (GO:0032429)	2.73577640
77	negative regulation of amino acid transport (GO:0051956)	2.71071055
78	cysteine metabolic process (GO:0006534)	2.70480338
79	primary alcohol metabolic process (GO:0034308)	2.69384268
80	cellular response to ethanol (GO:0071361)	2.68129766
81	cellular ketone body metabolic process (GO:0046950)	2.64626704
82	retinol metabolic process (GO:0042572)	2.63422268
83	organ formation (GO:0048645)	2.62951535
84	progesterone metabolic process (GO:0042448)	2.60643296
85	drug transmembrane transport (GO:0006855)	2.60412230
86	photoreceptor cell maintenance (GO:0045494)	2.59806679
87	positive regulation of glomerulus development (GO:0090193)	2.58490003
88	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.57139294
89	water-soluble vitamin biosynthetic process (GO:0042364)	2.56763771
90	magnesium ion transport (GO:0015693)	2.53249161
91	positive regulation of neurological system process (GO:0031646)	2.53138429
92	early endosome to late endosome transport (GO:0045022)	2.51279977
93	cornea development in camera-type eye (GO:0061303)	2.50727307
94	negative regulation of cell aging (GO:0090344)	2.48944538
95	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.47641545
96	genitalia morphogenesis (GO:0035112)	2.46770365
97	Sertoli cell development (GO:0060009)	2.44943996
98	* drug metabolic process (GO:0017144)	2.43637536
99	hair follicle morphogenesis (GO:0031069)	2.40050034
100	positive regulation of action potential (GO:0045760)	2.39537026

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.09900371
2	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.95987831
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.81097372
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.71329827
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.63819651
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.50865096
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.44852867
8	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.33744833
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31982949
10	FUS_26573619_Chip-Seq_HEK293_Human	2.30285413
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.27143077
12	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.19147006
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.16325734
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.16237848
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08761666
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.07752496
17	P300_19829295_ChIP-Seq_ESCs_Human	2.07524404
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.97108744
19	EWS_26573619_Chip-Seq_HEK293_Human	1.92108864
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88329327
21	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.84270738
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.76210394
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.75524516
24	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.74996854
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.71372214
26	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.71219476
27	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.70987287
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.68673734
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68673734
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65900338
31	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62192542
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.61536399
33	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.61013447
34	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.60647253
35	AR_25329375_ChIP-Seq_VCAP_Human	1.60430856
36	CJUN_26792858_Chip-Seq_BT549_Human	1.58994514
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.58527701
38	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.56891571
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56527091
40	STAT3_23295773_ChIP-Seq_U87_Human	1.54676280
41	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.54655251
42	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.54438445
43	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.54438445
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.54120946
45	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.52847894
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49591292
47	TP53_18474530_ChIP-ChIP_U2OS_Human	1.47745508
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.47632025
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47072427
50	P53_22387025_ChIP-Seq_ESCs_Mouse	1.45988775
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.45921473
52	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.43449247
53	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.42576754
54	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.42363942
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41358120
56	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.40871582
57	CDX2_22108803_ChIP-Seq_LS180_Human	1.40278525
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39230317
59	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.38100977
60	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.37324021
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37239238
62	TCF4_23295773_ChIP-Seq_U87_Human	1.36375736
63	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.35753998
64	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.35010777
65	AHR_22903824_ChIP-Seq_MCF-7_Human	1.32397241
66	P300_18555785_Chip-Seq_ESCs_Mouse	1.31632947
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30306421
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30306421
69	* SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.29176927
70	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.29137358
71	TP63_23658742_ChIP-Seq_EP156T_Human	1.28395802
72	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.28208022
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27408225
74	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.26153924
75	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.26024471
76	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24821068
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22841481
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22282115
79	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.21250265
80	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21017009
81	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20086909
82	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.18392449
83	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.17785878
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17692879
85	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.16901068
86	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.12046411
87	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.11947590
88	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.07825626
89	HTT_18923047_ChIP-ChIP_STHdh_Human	1.06540601
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06195282
91	KDM2B_26808549_Chip-Seq_REH_Human	1.06100949
92	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.06002413
93	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05640073
94	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05559281
95	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05559281
96	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.05289148
97	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.05034595
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04681392
99	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04284414
100	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.03841924

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000383_abnormal_hair_follicle	4.23138193
2	MP0002139_abnormal_hepatobiliary_system	4.01475873
3	MP0002138_abnormal_hepatobiliary_system	3.72882934
4	MP0010678_abnormal_skin_adnexa	3.65969442
5	MP0010386_abnormal_urinary_bladder	3.42712845
6	MP0003195_calcinosis	3.38943258
7	MP0004043_abnormal_pH_regulation	3.24898654
8	MP0000427_abnormal_hair_cycle	3.14609875
9	MP0000579_abnormal_nail_morphology	3.06895525
10	MP0002796_impaired_skin_barrier	2.92127100
11	MP0005275_abnormal_skin_tensile	2.83303326
12	MP0008875_abnormal_xenobiotic_pharmacok	2.66151689
13	MP0002234_abnormal_pharynx_morphology	2.55934056
14	MP0003252_abnormal_bile_duct	2.48049687
15	MP0004885_abnormal_endolymph	2.08279585
16	MP0010234_abnormal_vibrissa_follicle	2.04894008
17	MP0002095_abnormal_skin_pigmentation	1.97320564
18	MP0000569_abnormal_digit_pigmentation	1.83007360
19	MP0005085_abnormal_gallbladder_physiolo	1.72614086
20	MP0005551_abnormal_eye_electrophysiolog	1.72499799
21	MP0001216_abnormal_epidermal_layer	1.68219901
22	MP0009697_abnormal_copulation	1.65447041
23	MP0000647_abnormal_sebaceous_gland	1.57187166
24	MP0000467_abnormal_esophagus_morphology	1.56393291
25	MP0005365_abnormal_bile_salt	1.55071196
26	MP0000372_irregular_coat_pigmentation	1.50601598
27	MP0008872_abnormal_physiological_respon	1.46208712
28	MP0003880_abnormal_central_pattern	1.44745252
29	MP0002098_abnormal_vibrissa_morphology	1.41986694
30	MP0005253_abnormal_eye_physiology	1.38512612
31	MP0003011_delayed_dark_adaptation	1.37349027
32	MP0005501_abnormal_skin_physiology	1.37232164
33	MP0004215_abnormal_myocardial_fiber	1.34570424
34	MP0005075_abnormal_melanosome_morpholog	1.33515594
35	MP0006072_abnormal_retinal_apoptosis	1.31627755
36	MP0004019_abnormal_vitamin_homeostasis	1.31542265
37	MP0005379_endocrine/exocrine_gland_phen	1.29107305
38	MP0000762_abnormal_tongue_morphology	1.28945219
39	MP0003283_abnormal_digestive_organ	1.26543295
40	MP0000371_diluted_coat_color	1.25729798
41	MP0010771_integument_phenotype	1.23532731
42	MP0001501_abnormal_sleep_pattern	1.19860982
43	MP0000613_abnormal_salivary_gland	1.19772779
44	MP0006292_abnormal_olfactory_placode	1.17826370
45	MP0002638_abnormal_pupillary_reflex	1.16647846
46	MP0000631_abnormal_neuroendocrine_gland	1.13176700
47	MP0001485_abnormal_pinna_reflex	1.10465000
48	MP0000377_abnormal_hair_follicle	1.09490105
49	MP0004782_abnormal_surfactant_physiolog	1.08157892
50	MP0002876_abnormal_thyroid_physiology	1.06879554
51	MP0008877_abnormal_DNA_methylation	1.04556982
52	MP0009046_muscle_twitch	1.04521506
53	MP0003943_abnormal_hepatobiliary_system	1.02354411
54	MP0008961_abnormal_basal_metabolism	0.97864607
55	MP0006276_abnormal_autonomic_nervous	0.97066085
56	MP0002233_abnormal_nose_morphology	0.96373524
57	MP0002909_abnormal_adrenal_gland	0.95870312
58	MP0000566_synostosis	0.94814432
59	MP0004147_increased_porphyrin_level	0.93025542
60	MP0001270_distended_abdomen	0.92877861
61	MP0002102_abnormal_ear_morphology	0.92358792
62	MP0003937_abnormal_limbs/digits/tail_de	0.91460674
63	MP0001879_abnormal_lymphatic_vessel	0.91402671
64	MP0003045_fibrosis	0.91130740
65	MP0005646_abnormal_pituitary_gland	0.90414815
66	MP0002928_abnormal_bile_duct	0.90268543
67	MP0001661_extended_life_span	0.88770438
68	MP0001764_abnormal_homeostasis	0.88172845
69	MP0005332_abnormal_amino_acid	0.86851136
70	MP0005248_abnormal_Harderian_gland	0.86783094
71	MP0005645_abnormal_hypothalamus_physiol	0.86016234
72	MP0000678_abnormal_parathyroid_gland	0.85405946
73	MP0000013_abnormal_adipose_tissue	0.84879077
74	MP0003755_abnormal_palate_morphology	0.84677106
75	MP0000367_abnormal_coat/_hair	0.84517875
76	MP0008775_abnormal_heart_ventricle	0.81265889
77	MP0004134_abnormal_chest_morphology	0.80818392
78	MP0003878_abnormal_ear_physiology	0.80750272
79	MP0005377_hearing/vestibular/ear_phenot	0.80750272
80	MP0002168_other_aberrant_phenotype	0.80521504
81	MP0005084_abnormal_gallbladder_morpholo	0.78481148
82	MP0001191_abnormal_skin_condition	0.77226374
83	MP0004484_altered_response_of	0.77059544
84	MP0003186_abnormal_redox_activity	0.75273863
85	MP0001756_abnormal_urination	0.74436206
86	MP0003453_abnormal_keratinocyte_physiol	0.73991666
87	MP0001324_abnormal_eye_pigmentation	0.73266050
88	MP0008057_abnormal_DNA_replication	0.73212515
89	MP0002751_abnormal_autonomic_nervous	0.73210943
90	MP0003868_abnormal_feces_composition	0.70580109
91	MP0003656_abnormal_erythrocyte_physiolo	0.70043164
92	MP0002938_white_spotting	0.67883153
93	MP0002163_abnormal_gland_morphology	0.67529892
94	MP0000049_abnormal_middle_ear	0.67430103
95	MP0001666_abnormal_nutrient_absorption	0.64026363
96	MP0005636_abnormal_mineral_homeostasis	0.62249855
97	MP0002693_abnormal_pancreas_physiology	0.61891513
98	MP0005174_abnormal_tail_pigmentation	0.61770435
99	MP0005395_other_phenotype	0.60722619
100	MP0009745_abnormal_behavioral_response	0.60496394

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Alopecia of scalp (HP:0002293)	4.92103848
2	Abnormality of the axillary hair (HP:0100134)	4.74785390
3	Abnormality of secondary sexual hair (HP:0009888)	4.74785390
4	Thick nail (HP:0001805)	4.62732647
5	Palmar hyperkeratosis (HP:0010765)	4.00291797
6	Abnormality of nail color (HP:0100643)	3.98851852
7	Palmoplantar hyperkeratosis (HP:0000972)	3.96301506
8	Hypoplastic labia majora (HP:0000059)	3.76913357
9	Prostate neoplasm (HP:0100787)	3.71717648
10	Oral leukoplakia (HP:0002745)	3.63079212
11	Abnormal hair laboratory examination (HP:0003328)	3.61146200
12	Fair hair (HP:0002286)	3.42436326
13	Abnormality of the labia majora (HP:0012881)	3.39235368
14	Abnormality of the renal collecting system (HP:0004742)	3.29619549
15	Erythroderma (HP:0001019)	3.29381059
16	Pancreatic cysts (HP:0001737)	3.22972193
17	Plantar hyperkeratosis (HP:0007556)	3.05227831
18	Corneal erosion (HP:0200020)	3.03099764
19	Duplicated collecting system (HP:0000081)	2.98613749
20	Abnormality of macular pigmentation (HP:0008002)	2.96385759
21	Generalized hypopigmentation of hair (HP:0011358)	2.95395017
22	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.91391901
23	Abnormality of the renal cortex (HP:0011035)	2.87612240
24	Follicular hyperkeratosis (HP:0007502)	2.85956077
25	Absent eyelashes (HP:0000561)	2.84745804
26	Erythema (HP:0010783)	2.83035574
27	Hyperventilation (HP:0002883)	2.80625337
28	Oligodontia (HP:0000677)	2.79860456
29	Congenital stationary night blindness (HP:0007642)	2.79853351
30	Pili torti (HP:0003777)	2.79516858
31	Hypotrichosis (HP:0001006)	2.79296379
32	Aplasia/hypoplasia of the uterus (HP:0008684)	2.73178611
33	Furrowed tongue (HP:0000221)	2.70288863
34	Slow-growing hair (HP:0002217)	2.67492911
35	Abnormality of hair growth rate (HP:0011363)	2.67492911
36	Widely spaced teeth (HP:0000687)	2.66280099
37	Septate vagina (HP:0001153)	2.65167135
38	Labial hypoplasia (HP:0000066)	2.61857921
39	Split foot (HP:0001839)	2.61209408
40	Woolly hair (HP:0002224)	2.60178629
41	Sparse eyelashes (HP:0000653)	2.55082687
42	Hypoplasia of the uterus (HP:0000013)	2.52208192
43	Anhidrosis (HP:0000970)	2.48067798
44	Depressed nasal tip (HP:0000437)	2.44383418
45	Blepharitis (HP:0000498)	2.42876148
46	Pancreatic fibrosis (HP:0100732)	2.40276644
47	True hermaphroditism (HP:0010459)	2.36179328
48	Conical tooth (HP:0000698)	2.36153156
49	Absent hair (HP:0002298)	2.35917250
50	Brittle hair (HP:0002299)	2.35426946
51	Abnormal sex determination (HP:0012244)	2.34445537
52	Sex reversal (HP:0012245)	2.34445537
53	Medial flaring of the eyebrow (HP:0010747)	2.33246230
54	Abnormality of the renal medulla (HP:0100957)	2.29499377
55	Hypoplastic female external genitalia (HP:0012815)	2.28340254
56	Metaphyseal dysplasia (HP:0100255)	2.23837205
57	Hypoplastic nipples (HP:0002557)	2.23203970
58	Abnormality of midbrain morphology (HP:0002418)	2.21425697
59	Molar tooth sign on MRI (HP:0002419)	2.21425697
60	Abnormality of the prostate (HP:0008775)	2.13866985
61	Congenital, generalized hypertrichosis (HP:0004540)	2.13634535
62	Renal cortical cysts (HP:0000803)	2.11706619
63	Chorioretinal atrophy (HP:0000533)	2.10814566
64	Nephronophthisis (HP:0000090)	2.10756241
65	Thyroiditis (HP:0100646)	2.03234529
66	Conjugated hyperbilirubinemia (HP:0002908)	2.02524497
67	Decreased central vision (HP:0007663)	2.01746049
68	Renal dysplasia (HP:0000110)	2.00881944
69	Sparse scalp hair (HP:0002209)	1.96494326
70	Ketosis (HP:0001946)	1.94487303
71	Lip pit (HP:0100267)	1.92201167
72	Attenuation of retinal blood vessels (HP:0007843)	1.91411267
73	Selective tooth agenesis (HP:0001592)	1.91094855
74	Abnormality of the nasal septum (HP:0000419)	1.88664747
75	Conjunctival hamartoma (HP:0100780)	1.88424611
76	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.84837956
77	Tubular atrophy (HP:0000092)	1.84252229
78	Gaze-evoked nystagmus (HP:0000640)	1.84009949
79	Nail dystrophy (HP:0008404)	1.83478632
80	Fine hair (HP:0002213)	1.80935064
81	Congenital primary aphakia (HP:0007707)	1.80805411
82	Breast hypoplasia (HP:0003187)	1.79868778
83	Abnormality of the labia (HP:0000058)	1.79525320
84	Right ventricular cardiomyopathy (HP:0011663)	1.79221018
85	Blue irides (HP:0000635)	1.78199628
86	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.72969156
87	Cystic liver disease (HP:0006706)	1.72796921
88	Neoplasm of the lung (HP:0100526)	1.71811380
89	Onycholysis (HP:0001806)	1.71746337
90	Hypothermia (HP:0002045)	1.71667404
91	Nephrogenic diabetes insipidus (HP:0009806)	1.71263935
92	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.71174875
93	Hypoplasia of the fovea (HP:0007750)	1.71174875
94	Increased corneal curvature (HP:0100692)	1.71052170
95	Keratoconus (HP:0000563)	1.71052170
96	Gait imbalance (HP:0002141)	1.70358941
97	Hypohidrosis (HP:0000966)	1.66410235
98	Proximal tubulopathy (HP:0000114)	1.65896273
99	Congenital ichthyosiform erythroderma (HP:0007431)	1.64948925
100	Generalized hypopigmentation (HP:0007513)	1.64149875

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.95168813
2	BCKDK	4.54910409
3	TGFBR1	3.35635179
4	EIF2AK3	2.95793942
5	MAP4K2	2.70615282
6	MST4	2.51933328
7	GRK1	2.37481448
8	PINK1	2.20289896
9	ZAK	2.18013268
10	ERBB3	2.13268626
11	ADRBK2	1.96735946
12	NUAK1	1.93385424
13	BMPR1B	1.92974922
14	CASK	1.92399236
15	ACVR1B	1.85669657
16	STK38L	1.77177570
17	STK39	1.63353790
18	IRAK1	1.60641376
19	MAP2K7	1.58790751
20	FER	1.53819509
21	MAP3K4	1.49693531
22	MAP3K12	1.48625213
23	WNK3	1.47390542
24	BRSK2	1.46084816
25	STK24	1.41099226
26	EIF2AK1	1.38829746
27	MAPK13	1.37850255
28	MAPKAPK3	1.37000069
29	BCR	1.36821887
30	AKT3	1.36483012
31	TRIM28	1.35679399
32	INSRR	1.34062197
33	PIK3CA	1.28091836
34	* PRKCE	1.25485599
35	SIK3	1.25145928
36	EPHA3	1.22080719
37	NLK	1.22040500
38	OXSR1	1.18876865
39	MST1R	1.17717296
40	CSNK1A1L	1.15405686
41	CSNK1G1	1.12838146
42	CSNK1G3	1.05425189
43	LMTK2	1.01806733
44	IKBKB	1.00537970
45	CSNK1G2	0.97862455
46	TXK	0.94649550
47	EPHA4	0.88557809
48	MAP3K2	0.85993246
49	WNK4	0.85329319
50	RPS6KA4	0.84246361
51	LATS1	0.80301196
52	TRPM7	0.79373025
53	NEK6	0.78696580
54	STK3	0.71147344
55	TAOK3	0.66189279
56	MET	0.62522287
57	TLK1	0.61813235
58	EPHA2	0.61489906
59	BMPR2	0.61405035
60	PRKG2	0.60448909
61	DYRK3	0.59171085
62	CAMKK2	0.57412406
63	PAK3	0.54753405
64	NTRK3	0.52060261
65	CSNK1A1	0.51863108
66	ABL1	0.51767256
67	MAPKAPK5	0.48671325
68	PLK2	0.48062379
69	SRPK1	0.47466690
70	ADRBK1	0.46799772
71	MKNK2	0.46373244
72	TNIK	0.45756627
73	PRKCQ	0.45402705
74	KIT	0.44029938
75	PIK3CG	0.40386682
76	FGFR3	0.40314891
77	PHKG1	0.39985636
78	PHKG2	0.39985636
79	ROCK1	0.39094592
80	SGK223	0.36289879
81	SGK494	0.36289879
82	IKBKE	0.35929166
83	FLT3	0.35883263
84	IRAK2	0.34523809
85	EIF2AK2	0.33961573
86	SGK2	0.33587659
87	CSNK1D	0.33553096
88	PBK	0.33495386
89	PDK2	0.33221581
90	MKNK1	0.32297589
91	PRKD2	0.31266400
92	RPS6KA5	0.30139965
93	ERBB4	0.30088151
94	CAMK2A	0.29326533
95	MAPK7	0.28834655
96	FGFR2	0.28716520
97	CDK19	0.28470233
98	MATK	0.27872369
99	ATM	0.27602309
100	CAMK2D	0.26189047

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.51826058
2	* Pentose and glucuronate interconversions_Homo sapiens_hsa00040	3.42116495
3	* Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.98432893
4	* Retinol metabolism_Homo sapiens_hsa00830	2.61735713
5	Phototransduction_Homo sapiens_hsa04744	2.55733100
6	* Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.51980049
7	* Chemical carcinogenesis_Homo sapiens_hsa05204	2.48441763
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.42342179
9	Propanoate metabolism_Homo sapiens_hsa00640	2.40039826
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.39507605
11	* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.19478027
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.16723388
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.06355493
14	Nitrogen metabolism_Homo sapiens_hsa00910	2.05042585
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.04390154
16	Butanoate metabolism_Homo sapiens_hsa00650	2.01978530
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.96840981
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.96518445
19	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.95947620
20	Circadian rhythm_Homo sapiens_hsa04710	1.92486292
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86403310
22	ABC transporters_Homo sapiens_hsa02010	1.75507466
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.73310849
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.72573183
25	Sulfur metabolism_Homo sapiens_hsa00920	1.72168313
26	* Starch and sucrose metabolism_Homo sapiens_hsa00500	1.58033707
27	Protein export_Homo sapiens_hsa03060	1.54684412
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.47870548
29	* Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.47430187
30	Nicotine addiction_Homo sapiens_hsa05033	1.46575047
31	Caffeine metabolism_Homo sapiens_hsa00232	1.46346343
32	Histidine metabolism_Homo sapiens_hsa00340	1.42293602
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32901520
34	* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.32507028
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.25853211
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22698064
37	Glutathione metabolism_Homo sapiens_hsa00480	1.21067995
38	Peroxisome_Homo sapiens_hsa04146	1.20799148
39	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.09344981
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.09134349
41	Glycerolipid metabolism_Homo sapiens_hsa00561	1.07910271
42	Sphingolipid metabolism_Homo sapiens_hsa00600	0.99070212
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98980901
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.96793638
45	Salivary secretion_Homo sapiens_hsa04970	0.93525970
46	Serotonergic synapse_Homo sapiens_hsa04726	0.91662185
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.90363911
48	Olfactory transduction_Homo sapiens_hsa04740	0.85240894
49	Basal transcription factors_Homo sapiens_hsa03022	0.84187432
50	Homologous recombination_Homo sapiens_hsa03440	0.81153540
51	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80921829
52	Galactose metabolism_Homo sapiens_hsa00052	0.76275400
53	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75484337
54	Regulation of autophagy_Homo sapiens_hsa04140	0.75346902
55	RNA degradation_Homo sapiens_hsa03018	0.73880409
56	Fatty acid degradation_Homo sapiens_hsa00071	0.72477885
57	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.70351312
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.68191556
59	Asthma_Homo sapiens_hsa05310	0.67365905
60	Renin secretion_Homo sapiens_hsa04924	0.65919538
61	Insulin secretion_Homo sapiens_hsa04911	0.64503048
62	Sulfur relay system_Homo sapiens_hsa04122	0.62577539
63	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61021516
64	Taste transduction_Homo sapiens_hsa04742	0.60916674
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60384094
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59052133
67	* Metabolic pathways_Homo sapiens_hsa01100	0.57834562
68	Tyrosine metabolism_Homo sapiens_hsa00350	0.56980692
69	Complement and coagulation cascades_Homo sapiens_hsa04610	0.55210691
70	Mineral absorption_Homo sapiens_hsa04978	0.54965720
71	Morphine addiction_Homo sapiens_hsa05032	0.53587074
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52925568
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52515498
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52243943
75	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.51868812
76	Long-term depression_Homo sapiens_hsa04730	0.51690654
77	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.51340587
78	Bile secretion_Homo sapiens_hsa04976	0.50237799
79	GABAergic synapse_Homo sapiens_hsa04727	0.48040098
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45115780
81	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.43620153
82	Folate biosynthesis_Homo sapiens_hsa00790	0.43288451
83	Primary immunodeficiency_Homo sapiens_hsa05340	0.40927321
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40368148
85	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40082172
86	Fatty acid elongation_Homo sapiens_hsa00062	0.35873197
87	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.34120494
88	Proteasome_Homo sapiens_hsa03050	0.33544404
89	Pancreatic secretion_Homo sapiens_hsa04972	0.33373653
90	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.32028733
91	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.29730127
92	Circadian entrainment_Homo sapiens_hsa04713	0.26813215
93	Lysine degradation_Homo sapiens_hsa00310	0.25829836
94	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.24385545
95	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.22904785
96	Phenylalanine metabolism_Homo sapiens_hsa00360	0.22753608
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.21860308
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.21400510
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.20962163
100	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.20123725

UGT1A7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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