ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	xenobiotic catabolic process (GO:0042178)	9.66838631
2	response to nitrosative stress (GO:0051409)	8.61955188
3	negative regulation of fatty acid transport (GO:2000192)	8.40452954
4	one-carbon compound transport (GO:0019755)	7.57332878
5	inner ear receptor cell differentiation (GO:0060113)	6.80631455
6	regulation of chemokine secretion (GO:0090196)	6.12998069
7	regulation of phospholipase A2 activity (GO:0032429)	6.12505553
8	mechanoreceptor differentiation (GO:0042490)	6.11028801
9	energy homeostasis (GO:0097009)	6.10891514
10	phenylpropanoid metabolic process (GO:0009698)	6.09059537
11	regulation of cholesterol biosynthetic process (GO:0045540)	5.97044669
12	regulation of skeletal muscle contraction (GO:0014819)	5.74158907
13	Notch signaling involved in heart development (GO:0061314)	5.70547479
14	negative regulation of lipase activity (GO:0060192)	5.27763499
15	L-ascorbic acid metabolic process (GO:0019852)	5.27384474
16	replicative senescence (GO:0090399)	5.03660378
17	auditory receptor cell differentiation (GO:0042491)	4.93897557
18	glutathione derivative metabolic process (GO:1901685)	4.90054640
19	glutathione derivative biosynthetic process (GO:1901687)	4.90054640
20	flavonoid metabolic process (GO:0009812)	4.81363366
21	glutathione metabolic process (GO:0006749)	4.43515621
22	relaxation of cardiac muscle (GO:0055119)	4.40260130
23	regulation of secondary heart field cardioblast proliferation (GO:0003266)	4.38722372
24	regulation of cardioblast proliferation (GO:0003264)	4.38722372
25	regulation of superoxide anion generation (GO:0032928)	4.36702574
26	positive regulation of chemokine secretion (GO:0090197)	4.27064679
27	cell differentiation involved in metanephros development (GO:0072202)	4.21482418
28	positive regulation of icosanoid secretion (GO:0032305)	4.17233912
29	benzene-containing compound metabolic process (GO:0042537)	4.15922028
30	nucleotide transmembrane transport (GO:1901679)	4.15193107
31	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	4.11138384
32	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	4.11049109
33	hormone catabolic process (GO:0042447)	4.09914762
34	aorta morphogenesis (GO:0035909)	4.02695696
35	amyloid precursor protein catabolic process (GO:0042987)	3.96334613
36	renal absorption (GO:0070293)	3.93383468
37	relaxation of muscle (GO:0090075)	3.91654719
38	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	3.88760208
39	pharyngeal system development (GO:0060037)	3.70311040
40	muscle cell migration (GO:0014812)	3.68495064
41	positive regulation of steroid biosynthetic process (GO:0010893)	3.66167691
42	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.58703174
43	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.58703174
44	glomerulus development (GO:0032835)	3.57281806
45	sulfur amino acid catabolic process (GO:0000098)	3.55334224
46	sensory perception of smell (GO:0007608)	3.53773984
47	heterotypic cell-cell adhesion (GO:0034113)	3.51435598
48	regulation of cholesterol metabolic process (GO:0090181)	3.49242510
49	negative regulation of organic acid transport (GO:0032891)	3.47707699
50	heart valve formation (GO:0003188)	3.44692836
51	polyol transport (GO:0015791)	3.41318394
52	positive regulation of fatty acid transport (GO:2000193)	3.37503178
53	hydrogen peroxide biosynthetic process (GO:0050665)	3.33919356
54	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.33211099
55	negative regulation of chondrocyte differentiation (GO:0032331)	3.32534320
56	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	3.32005016
57	removal of superoxide radicals (GO:0019430)	3.28340650
58	cellular response to superoxide (GO:0071451)	3.28340650
59	cellular response to oxygen radical (GO:0071450)	3.28340650
60	outer ear morphogenesis (GO:0042473)	3.25217023
61	L-serine transport (GO:0015825)	3.24133368
62	outflow tract septum morphogenesis (GO:0003148)	3.20820037
63	relaxation of smooth muscle (GO:0044557)	3.17504968
64	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.14764622
65	regulation of icosanoid secretion (GO:0032303)	3.09794972
66	galactose metabolic process (GO:0006012)	3.04381958
67	generation of neurons (GO:0048699)	3.04375077
68	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.02469490
69	sulfation (GO:0051923)	3.01712974
70	neurofilament cytoskeleton organization (GO:0060052)	3.00011627
71	neuronal ion channel clustering (GO:0045161)	2.99221583
72	regulation of superoxide metabolic process (GO:0090322)	2.98569894
73	iron ion import (GO:0097286)	2.96464621
74	reactive oxygen species biosynthetic process (GO:1903409)	2.93830972
75	positive regulation of cholesterol efflux (GO:0010875)	2.91653496
76	proline transport (GO:0015824)	2.91159017
77	artery smooth muscle contraction (GO:0014824)	2.90485519
78	heart valve morphogenesis (GO:0003179)	2.89517319
79	bone remodeling (GO:0046849)	2.82129865
80	positive regulation of actin filament depolymerization (GO:0030836)	2.80190864
81	carnitine metabolic process (GO:0009437)	2.78312833
82	positive regulation of hormone biosynthetic process (GO:0046886)	2.77161692
83	positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)	2.76280467
84	endocardial cushion morphogenesis (GO:0003203)	2.76196625
85	serine transport (GO:0032329)	2.71851584
86	positive regulation of signal transduction by p53 class mediator (GO:1901798)	2.71349710
87	positive regulation of cellular response to oxidative stress (GO:1900409)	2.70207633
88	positive regulation of response to oxidative stress (GO:1902884)	2.70207633
89	hair cell differentiation (GO:0035315)	2.66190860
90	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.63963572
91	xenobiotic metabolic process (GO:0006805)	2.63445243
92	retina homeostasis (GO:0001895)	2.63009844
93	positive regulation of cholesterol transport (GO:0032376)	2.62649152
94	positive regulation of sterol transport (GO:0032373)	2.62649152
95	regulation of branching involved in ureteric bud morphogenesis (GO:0090189)	2.61955199
96	response to superoxide (GO:0000303)	2.60924220
97	prostanoid metabolic process (GO:0006692)	2.60593104
98	uronic acid metabolic process (GO:0006063)	13.4128396
99	glucuronate metabolic process (GO:0019585)	13.4128396
100	cellular glucuronidation (GO:0052695)	12.8957401

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	5.37592254
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.04540316
3	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.39232340
4	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.18576290
5	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.67806733
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.67662635
7	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.65829085
8	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.43845283
9	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.41077337
10	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.34847502
11	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.21294829
12	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.19114061
13	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.15237318
14	CLOCK_20551151_ChIP-Seq_293T_Human	2.11986633
15	AHR_22903824_ChIP-Seq_MCF-7_Human	2.08433765
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.05275232
17	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.82595881
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.75437030
19	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.74348988
20	TP53_18474530_ChIP-ChIP_U2OS_Human	1.71104459
21	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.69775774
22	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.69391390
23	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.68596500
24	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.68596500
25	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.64337247
26	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.59914356
27	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.53052296
28	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52137099
29	ZNF263_19887448_ChIP-Seq_K562_Human	1.51917747
30	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.50325093
31	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.50159030
32	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.47613096
33	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.46390492
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.44022018
35	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.43171567
36	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.43171567
37	AR_21572438_ChIP-Seq_LNCaP_Human	1.42997360
38	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.39733707
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.38135162
40	SOX2_20726797_ChIP-Seq_SW620_Human	1.33967883
41	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.29384739
42	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.26794906
43	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.25210475
44	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.23331554
45	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.22739619
46	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.22739619
47	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.22355467
48	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.21959042
49	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.21889735
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.20737526
51	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.19781976
52	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.18626917
53	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17300528
54	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.17141951
55	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.15780213
56	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.15596045
57	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.14565539
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.09558951
59	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.09072455
60	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.09002761
61	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.08941679
62	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.08656469
63	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.08656469
64	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.08656469
65	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.08417605
66	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.05859358
67	* ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.04817086
68	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03162431
69	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.02746730
70	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.99766412
71	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.98689689
72	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98257796
73	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.97875734
74	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.97534913
75	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.97034123
76	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.94383172
77	GBX2_23144817_ChIP-Seq_PC3_Human	0.92499883
78	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.91412066
79	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.91133817
80	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.90254351
81	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.89555479
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.89399013
83	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.89264620
84	CJUN_26792858_Chip-Seq_BT549_Human	0.88652407
85	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.88098476
86	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.87906485
87	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.87798678
88	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.86474392
89	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.86434407
90	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.85701360
91	* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.85401014
92	KLF5_25053715_ChIP-Seq_YYC3_Human	0.84777298
93	RUNX_20019798_ChIP-Seq_JUKART_Human	0.83767604
94	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.82512089
95	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.81999188
96	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.81442919
97	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.80652118
98	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.80234504
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.80229256
100	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.80034105

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005394_taste/olfaction_phenotype	8.09017802
2	MP0005499_abnormal_olfactory_system	8.09017802
3	MP0008789_abnormal_olfactory_epithelium	6.87690743
4	MP0008875_abnormal_xenobiotic_pharmacok	6.15868405
5	MP0001984_abnormal_olfaction	5.84106849
6	MP0010030_abnormal_orbit_morphology	3.43170252
7	MP0005377_hearing/vestibular/ear_phenot	3.25906698
8	MP0003878_abnormal_ear_physiology	3.25906698
9	MP0002877_abnormal_melanocyte_morpholog	2.88965781
10	MP0003186_abnormal_redox_activity	2.53373549
11	MP0002254_reproductive_system_inflammat	2.52152390
12	MP0002233_abnormal_nose_morphology	2.07155731
13	MP0009053_abnormal_anal_canal	2.02013028
14	MP0001346_abnormal_lacrimal_gland	1.72292539
15	MP0000762_abnormal_tongue_morphology	1.69543375
16	MP0000678_abnormal_parathyroid_gland	1.66210260
17	MP0005365_abnormal_bile_salt	1.62109225
18	MP0000613_abnormal_salivary_gland	1.60365103
19	MP0003279_aneurysm	1.58147518
20	MP0005085_abnormal_gallbladder_physiolo	1.49105553
21	MP0001919_abnormal_reproductive_system	1.31386712
22	MP0003941_abnormal_skin_development	1.28603373
23	MP0006292_abnormal_olfactory_placode	1.24986142
24	MP0009250_abnormal_appendicular_skeleto	1.23946097
25	MP0002132_abnormal_respiratory_system	1.23892280
26	MP0002098_abnormal_vibrissa_morphology	1.23513121
27	MP0000049_abnormal_middle_ear	1.16774124
28	MP0004264_abnormal_extraembryonic_tissu	1.13516919
29	MP0002295_abnormal_pulmonary_circulatio	1.13114519
30	MP0000467_abnormal_esophagus_morphology	1.08899075
31	MP0000534_abnormal_ureter_morphology	1.07911103
32	MP0002009_preneoplasia	1.07887949
33	MP0003828_pulmonary_edema	1.03386813
34	MP0010368_abnormal_lymphatic_system	1.02449652
35	MP0002249_abnormal_larynx_morphology	1.02140369
36	MP0000566_synostosis	1.00948508
37	MP0001958_emphysema	0.93688916
38	MP0005197_abnormal_uvea_morphology	0.91886331
39	MP0003786_premature_aging	0.91610783
40	MP0005388_respiratory_system_phenotype	0.90775973
41	MP0002133_abnormal_respiratory_system	0.90775973
42	MP0005408_hypopigmentation	0.86939965
43	MP0009379_abnormal_foot_pigmentation	0.85782177
44	MP0005248_abnormal_Harderian_gland	0.82325120
45	MP0003937_abnormal_limbs/digits/tail_de	0.81016988
46	MP0002277_abnormal_respiratory_mucosa	0.79411021
47	MP0005389_reproductive_system_phenotype	0.78629170
48	MP0010329_abnormal_lipoprotein_level	0.77999731
49	MP0004043_abnormal_pH_regulation	0.77512818
50	MP0008872_abnormal_physiological_respon	0.74709597
51	MP0005266_abnormal_metabolism	0.74190277
52	MP0002090_abnormal_vision	0.72988843
53	MP0003566_abnormal_cell_adhesion	0.72788052
54	MP0004147_increased_porphyrin_level	0.72767670
55	MP0005647_abnormal_sex_gland	0.72290757
56	MP0001177_atelectasis	0.71789418
57	MP0001849_ear_inflammation	0.71356292
58	MP0002653_abnormal_ependyma_morphology	0.70213494
59	MP0003806_abnormal_nucleotide_metabolis	0.66374622
60	MP0003942_abnormal_urinary_system	0.65265018
61	MP0006072_abnormal_retinal_apoptosis	0.65069760
62	MP0002177_abnormal_outer_ear	0.61559204
63	MP0001851_eye_inflammation	0.60553457
64	MP0003755_abnormal_palate_morphology	0.60454403
65	MP0002928_abnormal_bile_duct	0.58816067
66	MP0001501_abnormal_sleep_pattern	0.57535973
67	MP0003075_altered_response_to	0.57333368
68	MP0001270_distended_abdomen	0.56004631
69	MP0002160_abnormal_reproductive_system	0.55866532
70	MP0000767_abnormal_smooth_muscle	0.55794107
71	MP0000372_irregular_coat_pigmentation	0.54738043
72	MP0002938_white_spotting	0.54704966
73	MP0002127_abnormal_cardiovascular_syste	0.54179965
74	MP0004134_abnormal_chest_morphology	0.53204381
75	MP0000579_abnormal_nail_morphology	0.52942740
76	MP0002168_other_aberrant_phenotype	0.51569571
77	MP0000383_abnormal_hair_follicle	0.51121982
78	MP0003453_abnormal_keratinocyte_physiol	0.48782208
79	MP0004782_abnormal_surfactant_physiolog	0.47528679
80	MP0002405_respiratory_system_inflammati	0.47341574
81	MP0002092_abnormal_eye_morphology	0.47080130
82	MP0005023_abnormal_wound_healing	0.46347009
83	MP0001485_abnormal_pinna_reflex	0.45687804
84	MP0003938_abnormal_ear_development	0.44304690
85	MP0000026_abnormal_inner_ear	0.43317722
86	MP0003385_abnormal_body_wall	0.42928957
87	MP0002751_abnormal_autonomic_nervous	0.41941980
88	MP0003690_abnormal_glial_cell	0.41924515
89	MP0005646_abnormal_pituitary_gland	0.41599435
90	MP0000465_gastrointestinal_hemorrhage	0.41205236
91	MP0001963_abnormal_hearing_physiology	0.40654941
92	MP0003890_abnormal_embryonic-extraembry	0.40556949
93	MP0004233_abnormal_muscle_weight	0.39664119
94	MP0002060_abnormal_skin_morphology	0.37450109
95	MP0005319_abnormal_enzyme/_coenzyme	0.37033209
96	MP0009765_abnormal_xenobiotic_induced	0.36977295
97	MP0005171_absent_coat_pigmentation	0.35747798
98	MP0005508_abnormal_skeleton_morphology	0.34654854
99	MP0001905_abnormal_dopamine_level	0.33635815
100	MP0003252_abnormal_bile_duct	0.33374945

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Potter facies (HP:0002009)	8.23215429
2	Facial shape deformation (HP:0011334)	8.23215429
3	Lip pit (HP:0100267)	6.39308495
4	Renal tubular acidosis (HP:0001947)	5.11867472
5	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	4.74602425
6	Redundant skin (HP:0001582)	4.65619845
7	Periauricular skin pits (HP:0100277)	4.37995598
8	Preauricular pit (HP:0004467)	4.37995598
9	Abnormal hemoglobin (HP:0011902)	4.37572590
10	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	4.30531261
11	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	3.90073408
12	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.85510737
13	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.77972096
14	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.77972096
15	Popliteal pterygium (HP:0009756)	3.61420974
16	Fibular aplasia (HP:0002990)	3.61094077
17	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	3.60565450
18	Humeroradial synostosis (HP:0003041)	3.50790219
19	Synostosis involving the elbow (HP:0003938)	3.50790219
20	Bifid scrotum (HP:0000048)	3.45575185
21	Stomach cancer (HP:0012126)	3.45561496
22	Bronchomalacia (HP:0002780)	3.42235512
23	Papillary thyroid carcinoma (HP:0002895)	3.40742632
24	Aplasia involving bones of the extremities (HP:0009825)	3.34434353
25	Aplasia involving bones of the upper limbs (HP:0009823)	3.34434353
26	Aplasia of the phalanges of the hand (HP:0009802)	3.34434353
27	Abnormality of the distal phalanges of the toes (HP:0010182)	3.31223048
28	Abnormality of the phalanges of the 5th finger (HP:0004213)	3.30884848
29	Abnormality of the middle phalanges of the toes (HP:0010183)	3.23450152
30	Skin pits (HP:0100276)	3.22055847
31	Stenosis of the external auditory canal (HP:0000402)	3.21186938
32	Cupped ear (HP:0000378)	3.19558311
33	Pulmonary artery stenosis (HP:0004415)	3.19244162
34	Renal tubular dysfunction (HP:0000124)	3.11483545
35	Glucose intolerance (HP:0000833)	2.95364359
36	Chorioretinal atrophy (HP:0000533)	2.90658054
37	Down-sloping shoulders (HP:0200021)	2.90618346
38	Renal dysplasia (HP:0000110)	2.85944119
39	Right ventricular cardiomyopathy (HP:0011663)	2.82076501
40	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.81220492
41	Labial hypoplasia (HP:0000066)	2.78556845
42	Renal cortical cysts (HP:0000803)	2.78019124
43	Hypoplasia of the ulna (HP:0003022)	2.74506519
44	Abnormality of the corticospinal tract (HP:0002492)	2.73998734
45	Abnormal tarsal ossification (HP:0008369)	2.71397125
46	Hypoplasia of the uterus (HP:0000013)	2.66906846
47	Vertebral arch anomaly (HP:0008438)	2.64693339
48	Vaginal fistula (HP:0004320)	2.60129447
49	Aplasia/Hypoplasia of the scapulae (HP:0006713)	2.59651203
50	Hypoplastic scapulae (HP:0000882)	2.59651203
51	Ulnar bowing (HP:0003031)	2.57961935
52	Tarsal synostosis (HP:0008368)	2.56759908
53	Hydroureter (HP:0000072)	2.49847029
54	Hemivertebrae (HP:0002937)	2.49801837
55	Hypoplastic female external genitalia (HP:0012815)	2.48455212
56	Split foot (HP:0001839)	2.47050885
57	Synostosis involving bones of the lower limbs (HP:0009138)	2.38839941
58	Synostosis involving bones of the feet (HP:0009140)	2.38839941
59	Abnormality of the renal collecting system (HP:0004742)	2.37481005
60	Urethral obstruction (HP:0000796)	2.37327957
61	Morphological abnormality of the middle ear (HP:0008609)	2.34020112
62	Abnormality of the 2nd finger (HP:0004100)	2.32828838
63	Hypoplastic labia majora (HP:0000059)	2.32373514
64	Progressive sensorineural hearing impairment (HP:0000408)	2.29769529
65	Short hallux (HP:0010109)	2.26434888
66	Absent eyebrow (HP:0002223)	2.23665458
67	Abnormality of the anterior horn cell (HP:0006802)	2.22684767
68	Degeneration of anterior horn cells (HP:0002398)	2.22684767
69	Prolonged neonatal jaundice (HP:0006579)	2.21213379
70	Abnormality of cochlea (HP:0000375)	2.20598726
71	Short middle phalanx of the 5th finger (HP:0004220)	2.19131973
72	Thyroid carcinoma (HP:0002890)	2.16943493
73	Pulmonary hypoplasia (HP:0002089)	2.16473322
74	Submucous cleft hard palate (HP:0000176)	2.15708833
75	Hypercholesterolemia (HP:0003124)	2.15201278
76	Bowed forearm bones (HP:0003956)	2.13294419
77	Bowing of the arm (HP:0006488)	2.13294419
78	Anterior segment dysgenesis (HP:0007700)	2.13195237
79	Aplasia/Hypoplasia of the ulna (HP:0006495)	2.12211079
80	Adactyly (HP:0009776)	2.11844893
81	Abnormality of the labia (HP:0000058)	2.09189856
82	Onycholysis (HP:0001806)	2.06419419
83	Abnormality of the labia majora (HP:0012881)	2.06247284
84	Aplasia/hypoplasia of the uterus (HP:0008684)	2.05795237
85	Pseudobulbar signs (HP:0002200)	2.05160033
86	Absent eyelashes (HP:0000561)	2.04369972
87	Dysphonia (HP:0001618)	2.03925495
88	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.01182556
89	Non-midline cleft lip (HP:0100335)	2.00834463
90	Abnormal glucose tolerance (HP:0001952)	1.99676094
91	Carpal synostosis (HP:0009702)	1.98713006
92	Sleep apnea (HP:0010535)	1.98648209
93	Steatorrhea (HP:0002570)	1.97011994
94	Syncope (HP:0001279)	1.95614672
95	Distal lower limb muscle weakness (HP:0009053)	1.93168212
96	Palpitations (HP:0001962)	1.92425663
97	Fair hair (HP:0002286)	1.92357586
98	Tubulointerstitial nephritis (HP:0001970)	1.89774265
99	Femoral bowing (HP:0002980)	1.89112891
100	Nuclear cataract (HP:0100018)	1.88090009

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K2	4.33198674
2	ZAK	4.08842261
3	MST4	3.86867543
4	MAP3K3	3.77855018
5	ERBB3	3.63407437
6	ADRBK2	3.41581762
7	BMPR2	2.99510742
8	RPS6KB2	2.84383596
9	MAPK15	2.76660983
10	MAP2K2	2.13853231
11	PAK3	1.98839839
12	MAP2K1	1.95312715
13	PBK	1.90552948
14	EPHA2	1.84744963
15	MAP3K14	1.72673751
16	BCKDK	1.70110341
17	CSNK1A1L	1.66373112
18	INSRR	1.53444872
19	NME1	1.51279468
20	HIPK2	1.45354701
21	TNIK	1.43350201
22	EPHB2	1.39576578
23	MAP3K13	1.33496342
24	TESK1	1.31392814
25	CAMKK2	1.28344659
26	CAMK1D	1.28142050
27	BMPR1B	1.27777370
28	MAP2K3	1.21172961
29	EPHB1	1.05260750
30	STK39	0.99345558
31	PRPF4B	0.99023890
32	MAP3K7	0.98240367
33	PRKD3	0.96580437
34	NUAK1	0.94576163
35	MAPKAPK5	0.92895109
36	MAP3K6	0.91883441
37	NLK	0.89467857
38	RIPK4	0.87705272
39	NEK6	0.87337310
40	STK4	0.86597300
41	CAMK1G	0.86041970
42	TRPM7	0.85008928
43	FER	0.83933496
44	CSNK1G3	0.83475946
45	TSSK6	0.83321537
46	CAMKK1	0.81803619
47	CAMK4	0.81491162
48	SGK2	0.80599966
49	CHUK	0.80509873
50	SIK1	0.77175714
51	PDGFRB	0.74643820
52	TRIB3	0.73575091
53	PRKCE	0.73112391
54	SGK223	0.69125337
55	SGK494	0.69125337
56	CASK	0.68312233
57	IKBKB	0.65854994
58	ERBB4	0.65172356
59	CAMK1	0.63910572
60	MAPKAPK3	0.61526807
61	RIPK1	0.61493801
62	STK10	0.61221058
63	MAP2K6	0.60851745
64	ERBB2	0.60820066
65	EPHA3	0.60505878
66	CSNK1G2	0.60218362
67	CDK6	0.60214758
68	CSNK1G1	0.58632380
69	TNK2	0.58632241
70	VRK1	0.55974429
71	PRKCI	0.53175400
72	PDK2	0.50698279
73	PHKG2	0.50333504
74	PHKG1	0.50333504
75	TXK	0.48877140
76	LATS2	0.47754902
77	MAPK7	0.46655272
78	ROCK2	0.45976185
79	SGK3	0.44413085
80	MKNK2	0.43872311
81	LIMK1	0.41696832
82	PRKD1	0.41211687
83	OXSR1	0.39056657
84	CAMK2D	0.38729189
85	CSNK1A1	0.38392738
86	TAOK2	0.37916035
87	STK38L	0.37788552
88	PINK1	0.37008597
89	MST1R	0.35384024
90	CAMK2B	0.33734179
91	MAP3K11	0.32931042
92	TEC	0.28698509
93	WNK1	0.27447991
94	GRK1	0.26988914
95	MARK2	0.24914234
96	ROCK1	0.23144113
97	IKBKE	0.23081134
98	DYRK1A	0.21815469
99	MAP3K1	0.20998605
100	LMTK2	0.19064614

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Pentose and glucuronate interconversions_Homo sapiens_hsa00040	6.16239768
2	* Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	5.53199041
3	* Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	4.83245192
4	* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	4.79277887
5	* Chemical carcinogenesis_Homo sapiens_hsa05204	4.25901936
6	Sulfur metabolism_Homo sapiens_hsa00920	3.91493718
7	* Steroid hormone biosynthesis_Homo sapiens_hsa00140	3.25647614
8	Glutathione metabolism_Homo sapiens_hsa00480	2.85678431
9	Caffeine metabolism_Homo sapiens_hsa00232	2.47392049
10	Butanoate metabolism_Homo sapiens_hsa00650	2.47109826
11	* Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.46735733
12	* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.41973305
13	* Starch and sucrose metabolism_Homo sapiens_hsa00500	2.41392513
14	Sulfur relay system_Homo sapiens_hsa04122	2.40377332
15	* Retinol metabolism_Homo sapiens_hsa00830	2.15043660
16	Galactose metabolism_Homo sapiens_hsa00052	1.66535836
17	ABC transporters_Homo sapiens_hsa02010	1.42302583
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.31655018
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.17308946
20	Mineral absorption_Homo sapiens_hsa04978	1.06754468
21	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.92120576
22	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90494049
23	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.89061138
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85924096
25	Peroxisome_Homo sapiens_hsa04146	0.83396344
26	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.77408965
27	Prion diseases_Homo sapiens_hsa05020	0.73453540
28	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.72219637
29	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67106927
30	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.65062424
31	Tight junction_Homo sapiens_hsa04530	0.63336473
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.59029856
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57243292
34	Circadian rhythm_Homo sapiens_hsa04710	0.57026478
35	Axon guidance_Homo sapiens_hsa04360	0.55620978
36	Gastric acid secretion_Homo sapiens_hsa04971	0.54694325
37	Melanoma_Homo sapiens_hsa05218	0.54193547
38	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52869559
39	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.49785279
40	Notch signaling pathway_Homo sapiens_hsa04330	0.49572519
41	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.48508052
42	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.48172974
43	Phagosome_Homo sapiens_hsa04145	0.46316322
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45785597
45	Olfactory transduction_Homo sapiens_hsa04740	0.38941443
46	Bile secretion_Homo sapiens_hsa04976	0.38192813
47	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.38025717
48	Vibrio cholerae infection_Homo sapiens_hsa05110	0.37766308
49	TNF signaling pathway_Homo sapiens_hsa04668	0.37717631
50	Adherens junction_Homo sapiens_hsa04520	0.36497487
51	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.35828024
52	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.34023419
53	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.33961989
54	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.32881438
55	Cocaine addiction_Homo sapiens_hsa05030	0.30411262
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29153733
57	Renin secretion_Homo sapiens_hsa04924	0.28773785
58	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.28629716
59	Amphetamine addiction_Homo sapiens_hsa05031	0.27451455
60	Phenylalanine metabolism_Homo sapiens_hsa00360	0.26669688
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.24696993
62	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.22709286
63	Prostate cancer_Homo sapiens_hsa05215	0.22313878
64	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.21843402
65	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.20849419
66	Fatty acid degradation_Homo sapiens_hsa00071	0.19978948
67	African trypanosomiasis_Homo sapiens_hsa05143	0.19646970
68	Type II diabetes mellitus_Homo sapiens_hsa04930	0.19163569
69	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.18946210
70	Hepatitis C_Homo sapiens_hsa05160	0.18711679
71	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.18684486
72	Tyrosine metabolism_Homo sapiens_hsa00350	0.18618216
73	Hippo signaling pathway_Homo sapiens_hsa04390	0.17936610
74	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.17500036
75	ECM-receptor interaction_Homo sapiens_hsa04512	0.17392241
76	MAPK signaling pathway_Homo sapiens_hsa04010	0.15287521
77	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.13984134
78	One carbon pool by folate_Homo sapiens_hsa00670	0.13337477
79	Propanoate metabolism_Homo sapiens_hsa00640	0.12933149
80	Histidine metabolism_Homo sapiens_hsa00340	0.12442977
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.12391044
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.12040290
83	Pentose phosphate pathway_Homo sapiens_hsa00030	0.11753119
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.11472583
85	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.11276588
86	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.10998898
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.10559844
88	Rap1 signaling pathway_Homo sapiens_hsa04015	0.10418577
89	PPAR signaling pathway_Homo sapiens_hsa03320	0.09497970
90	Prolactin signaling pathway_Homo sapiens_hsa04917	0.08822037
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.06501378
92	* Metabolic pathways_Homo sapiens_hsa01100	0.06418791
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.05582613
94	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.03931983
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.03385765
96	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.02079683
97	Complement and coagulation cascades_Homo sapiens_hsa04610	0.01999785
98	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.01854911
99	Pertussis_Homo sapiens_hsa05133	0.01509483
100	RNA degradation_Homo sapiens_hsa03018	0.01225791

UGT2A2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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