ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	angiotensin maturation (GO:0002003)	8.08459022
2	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	7.65360333
3	L-phenylalanine catabolic process (GO:0006559)	7.61313562
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.61313562
5	L-phenylalanine metabolic process (GO:0006558)	7.26658024
6	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.26658024
7	intestinal absorption (GO:0050892)	6.94136043
8	aromatic amino acid family catabolic process (GO:0009074)	6.91092576
9	epoxygenase P450 pathway (GO:0019373)	6.73096426
10	lipoprotein transport (GO:0042953)	6.64791937
11	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.27566460
12	tryptophan catabolic process (GO:0006569)	6.27486383
13	indole-containing compound catabolic process (GO:0042436)	6.27486383
14	indolalkylamine catabolic process (GO:0046218)	6.27486383
15	kynurenine metabolic process (GO:0070189)	6.11903583
16	bile acid biosynthetic process (GO:0006699)	6.09804565
17	tryptophan metabolic process (GO:0006568)	5.90174472
18	urea cycle (GO:0000050)	5.81182310
19	urea metabolic process (GO:0019627)	5.81182310
20	glyoxylate metabolic process (GO:0046487)	5.74539374
21	alpha-linolenic acid metabolic process (GO:0036109)	5.56021786
22	negative regulation of fibrinolysis (GO:0051918)	5.48767913
23	high-density lipoprotein particle remodeling (GO:0034375)	5.47718558
24	complement activation, alternative pathway (GO:0006957)	5.46876359
25	cysteine metabolic process (GO:0006534)	5.39848926
26	fat-soluble vitamin biosynthetic process (GO:0042362)	5.39020014
27	sulfur amino acid catabolic process (GO:0000098)	5.38042774
28	regulation of protein activation cascade (GO:2000257)	5.36010289
29	nitrogen cycle metabolic process (GO:0071941)	5.34301989
30	peptidyl-glutamic acid carboxylation (GO:0017187)	5.33493492
31	protein carboxylation (GO:0018214)	5.33493492
32	regulation of fibrinolysis (GO:0051917)	5.31327826
33	bile acid metabolic process (GO:0008206)	5.19200085
34	serine family amino acid catabolic process (GO:0009071)	5.14698149
35	regulation of complement activation (GO:0030449)	5.03707163
36	intestinal cholesterol absorption (GO:0030299)	5.01863725
37	aromatic amino acid family metabolic process (GO:0009072)	5.01788701
38	homocysteine metabolic process (GO:0050667)	4.94646552
39	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.90135236
40	regulation of triglyceride catabolic process (GO:0010896)	4.86299744
41	endocrine process (GO:0050886)	4.83018955
42	regulation of systemic arterial blood pressure by hormone (GO:0001990)	4.83018955
43	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	4.83018955
44	tyrosine metabolic process (GO:0006570)	4.82172160
45	regulation of cholesterol esterification (GO:0010872)	4.77731286
46	reverse cholesterol transport (GO:0043691)	4.75369240
47	NADH metabolic process (GO:0006734)	4.74429095
48	* uronic acid metabolic process (GO:0006063)	4.70417102
49	* glucuronate metabolic process (GO:0019585)	4.70417102
50	plasma lipoprotein particle remodeling (GO:0034369)	4.69901697
51	protein-lipid complex remodeling (GO:0034368)	4.69901697
52	macromolecular complex remodeling (GO:0034367)	4.69901697
53	alpha-amino acid catabolic process (GO:1901606)	4.69732441
54	lysine catabolic process (GO:0006554)	4.67541968
55	lysine metabolic process (GO:0006553)	4.67541968
56	amino-acid betaine metabolic process (GO:0006577)	4.61210546
57	triglyceride homeostasis (GO:0070328)	4.59233902
58	acylglycerol homeostasis (GO:0055090)	4.59233902
59	hormone catabolic process (GO:0042447)	4.56717522
60	negative regulation of sterol transport (GO:0032372)	4.55321582
61	negative regulation of cholesterol transport (GO:0032375)	4.55321582
62	drug metabolic process (GO:0017144)	4.54118867
63	bile acid and bile salt transport (GO:0015721)	4.51749123
64	diacylglycerol metabolic process (GO:0046339)	4.49853103
65	phospholipid efflux (GO:0033700)	4.49620191
66	coenzyme catabolic process (GO:0009109)	4.48642452
67	glycine metabolic process (GO:0006544)	4.47504377
68	indolalkylamine metabolic process (GO:0006586)	4.44812463
69	regulation of guanylate cyclase activity (GO:0031282)	4.41208637
70	imidazole-containing compound metabolic process (GO:0052803)	4.38939823
71	cellular ketone body metabolic process (GO:0046950)	4.38750185
72	lipoprotein metabolic process (GO:0042157)	4.37663018
73	amine catabolic process (GO:0009310)	4.35555119
74	cellular biogenic amine catabolic process (GO:0042402)	4.35555119
75	cellular amino acid catabolic process (GO:0009063)	4.31787285
76	plasma lipoprotein particle clearance (GO:0034381)	4.30143975
77	glutamate metabolic process (GO:0006536)	4.25987308
78	serine family amino acid metabolic process (GO:0009069)	4.22709928
79	ethanol oxidation (GO:0006069)	4.18809429
80	cholesterol efflux (GO:0033344)	4.18287159
81	benzene-containing compound metabolic process (GO:0042537)	4.16635181
82	regulation of systemic arterial blood pressure (GO:0003073)	4.08937596
83	cellular modified amino acid catabolic process (GO:0042219)	4.07758455
84	fructose metabolic process (GO:0006000)	4.07708288
85	arginine metabolic process (GO:0006525)	4.07045214
86	dicarboxylic acid biosynthetic process (GO:0043650)	4.05482283
87	serine family amino acid biosynthetic process (GO:0009070)	4.03928724
88	aldehyde catabolic process (GO:0046185)	4.01758161
89	low-density lipoprotein particle remodeling (GO:0034374)	4.00484349
90	drug catabolic process (GO:0042737)	3.98215210
91	plasma lipoprotein particle assembly (GO:0034377)	3.96129891
92	fibrinolysis (GO:0042730)	3.93213358
93	protein-lipid complex subunit organization (GO:0071825)	3.90744988
94	drug transmembrane transport (GO:0006855)	3.89685332
95	regulation of bile acid biosynthetic process (GO:0070857)	3.86258293
96	cofactor catabolic process (GO:0051187)	3.83428842
97	exogenous drug catabolic process (GO:0042738)	3.82909458
98	cytolysis (GO:0019835)	3.81761989
99	complement activation, classical pathway (GO:0006958)	3.81568930
100	ketone body metabolic process (GO:1902224)	3.79778591
101	very-low-density lipoprotein particle assembly (GO:0034379)	3.79168265
102	blood coagulation, intrinsic pathway (GO:0007597)	3.78971482
103	complement activation (GO:0006956)	3.78240835
104	organic acid catabolic process (GO:0016054)	3.76976749
105	carboxylic acid catabolic process (GO:0046395)	3.76976749
106	cholesterol homeostasis (GO:0042632)	3.76098103
107	acetyl-CoA metabolic process (GO:0006084)	3.75991728
108	drinking behavior (GO:0042756)	3.75887744
109	positive regulation of lipoprotein lipase activity (GO:0051006)	3.74642817
110	positive regulation of triglyceride lipase activity (GO:0061365)	3.74642817
111	positive regulation of lipid catabolic process (GO:0050996)	3.74392137
112	omega-hydroxylase P450 pathway (GO:0097267)	3.72720897
113	protein activation cascade (GO:0072376)	3.72450569
114	phospholipid homeostasis (GO:0055091)	3.71176191
115	sterol homeostasis (GO:0055092)	3.69892525
116	* cellular glucuronidation (GO:0052695)	3.69655109
117	digestion (GO:0007586)	3.68930255
118	negative regulation of lipase activity (GO:0060192)	3.68605864
119	short-chain fatty acid metabolic process (GO:0046459)	3.68486221
120	drug transport (GO:0015893)	3.67371470
121	regulation of cholesterol homeostasis (GO:2000188)	3.61768805
122	NAD biosynthetic process (GO:0009435)	3.58275233
123	flavonoid metabolic process (GO:0009812)	3.57806620
124	plasma lipoprotein particle organization (GO:0071827)	3.56965559
125	protein-lipid complex assembly (GO:0065005)	3.55631235
126	pyridine nucleotide biosynthetic process (GO:0019363)	3.54830080
127	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.54830080
128	glutamine family amino acid biosynthetic process (GO:0009084)	3.53373597
129	maintenance of gastrointestinal epithelium (GO:0030277)	3.52683679
130	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.52572388
131	positive regulation of guanylate cyclase activity (GO:0031284)	3.46584411
132	vitamin transmembrane transport (GO:0035461)	3.43134514
133	urate metabolic process (GO:0046415)	3.37159585
134	peptide hormone processing (GO:0016486)	3.31714357
135	transepithelial transport (GO:0070633)	3.28956342
136	transcytosis (GO:0045056)	3.27621091
137	sulfate transmembrane transport (GO:1902358)	3.26160219
138	regulation of cholesterol metabolic process (GO:0090181)	3.25112251
139	renal system process involved in regulation of blood volume (GO:0001977)	3.24597421
140	peptide catabolic process (GO:0043171)	3.22303269
141	proline metabolic process (GO:0006560)	3.22151607
142	glycolipid catabolic process (GO:0019377)	3.21999052
143	digestive system process (GO:0022600)	3.20450814
144	regulation of apoptotic cell clearance (GO:2000425)	3.18815332
145	L-ascorbic acid metabolic process (GO:0019852)	3.17038385
146	proline biosynthetic process (GO:0006561)	3.10285917
147	vitamin transport (GO:0051180)	3.09859302
148	glycosphingolipid catabolic process (GO:0046479)	3.08255183
149	lipid homeostasis (GO:0055088)	3.08190416
150	heme transport (GO:0015886)	3.07378742
151	modified amino acid transport (GO:0072337)	3.07185907
152	vitamin biosynthetic process (GO:0009110)	3.04550535
153	ethanol metabolic process (GO:0006067)	3.03017737
154	mRNA modification (GO:0016556)	3.01307675
155	regulation of cellular extravasation (GO:0002691)	2.98152011
156	fat-soluble vitamin metabolic process (GO:0006775)	2.97611788

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	8.39545464
2	PPARA_22158963_ChIP-Seq_LIVER_Mouse	7.19608823
3	* EGR1_23403033_ChIP-Seq_LIVER_Mouse	7.07640295
4	* LXR_22158963_ChIP-Seq_LIVER_Mouse	6.50352406
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.30149983
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	5.08049651
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.74518755
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	4.05631925
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.98952473
10	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.50896775
11	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.44481088
12	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.27616609
13	SOX2_20726797_ChIP-Seq_SW620_Human	2.23139813
14	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.11435851
15	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.08763738
16	TCF4_18268006_ChIP-ChIP_LS174T_Human	2.03622098
17	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.9461409
18	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.99018755
19	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.93415232
20	HTT_18923047_ChIP-ChIP_STHdh_Human	1.61595646
21	* FOXA2_19822575_ChIP-Seq_HepG2_Human	1.58628137
22	CLOCK_20551151_ChIP-Seq_293T_Human	1.55499065
23	AR_21909140_ChIP-Seq_LNCAP_Human	1.48002782
24	GATA1_22025678_ChIP-Seq_K562_Human	1.44378365
25	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.40425788
26	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.35384172
27	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.27789969
28	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.24224586
29	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.19232290
30	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.19221170
31	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.19121731
32	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.18894590
33	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.09563717
34	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.01992435
35	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.99941748
36	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.99778826
37	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.98238042
38	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.96796686
39	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.96433213
40	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.95423936
41	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.94941917
42	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.93919448
43	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.92665639
44	RXR_22108803_ChIP-Seq_LS180_Human	0.90563584
45	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.90044121
46	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.86777945
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.86461885
48	GATA4_25053715_ChIP-Seq_YYC3_Human	0.83911982
49	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.83907645
50	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.83331507
51	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.81890531
52	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.81418581
53	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.81335816
54	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.79928201
55	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.79028414
56	TP63_23658742_ChIP-Seq_EP156T_Human	0.78807350
57	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.78670298
58	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.78312177
59	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.76491219
60	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.75116565
61	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.74978049
62	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.74633307
63	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.74388354
64	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.73934994
65	ZNF263_19887448_ChIP-Seq_K562_Human	0.73759038
66	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.73738902
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.73421005
68	* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.73209217
69	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.72567034
70	CJUN_26792858_Chip-Seq_BT549_Human	0.70757968
71	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.70497469
72	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.69736278
73	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.69333311
74	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.67659477
75	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.67659477
76	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.67613199
77	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.67344336
78	KLF5_25053715_ChIP-Seq_YYC3_Human	0.66602420
79	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.66575104
80	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.66268187
81	RACK7_27058665_Chip-Seq_MCF-7_Human	0.66046319
82	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.65328457
83	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.65028993
84	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.64546537
85	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.63895395
86	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.63549112
87	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.63385257
88	TP53_18474530_ChIP-ChIP_U2OS_Human	0.62108083
89	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.61974560
90	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.61700241
91	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.60162866
92	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.59965745
93	TP53_16413492_ChIP-PET_HCT116_Human	0.59897957
94	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.59380733
95	* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.59200342
96	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.56874151
97	EGR1_19032775_ChIP-ChIP_M12_Human	0.55927329
98	* CEBPB_22108803_ChIP-Seq_LS180_Human	0.54998701
99	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.54181708
100	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.53665372
101	TAF15_26573619_Chip-Seq_HEK293_Human	0.53629730
102	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.53437295
103	AR_20517297_ChIP-Seq_VCAP_Human	0.53176214
104	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.52923270
105	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.51561420
106	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.51516679
107	MYC_19915707_ChIP-ChIP_AK7_Human	0.51489817
108	STAT1_17558387_ChIP-Seq_HELA_Human	0.50211920
109	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.50198017
110	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.49960954
111	CBP_21632823_ChIP-Seq_H3396_Human	0.49677709
112	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.49318770
113	LXR_22292898_ChIP-Seq_THP-1_Human	0.48440753
114	P53_21459846_ChIP-Seq_SAOS-2_Human	0.46682177
115	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.45654350
116	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.44906197
117	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.43507526
118	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.43343621
119	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.43281621
120	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.43242639
121	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.42707671
122	BCAT_22108803_ChIP-Seq_LS180_Human	0.42401694
123	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.41193669
124	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.41080058
125	TAF2_19829295_ChIP-Seq_ESCs_Human	0.40652810
126	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.40499162
127	GATA1_19941826_ChIP-Seq_K562_Human	0.39096393
128	GATA2_19941826_ChIP-Seq_K562_Human	0.38813155
129	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.38761123
130	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.38696137
131	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.38650011
132	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.38602402
133	* GATA6_25053715_ChIP-Seq_YYC3_Human	0.38444174
134	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.36448970
135	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.36117478
136	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.36061294
137	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.35965054
138	NCOR_22424771_ChIP-Seq_293T_Human	0.35252337
139	SPI1_26923725_Chip-Seq_HPCs_Mouse	0.34787304
140	ERG_20517297_ChIP-Seq_VCAP_Human	0.34590064
141	CDX2_22108803_ChIP-Seq_LS180_Human	0.34481453
142	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.34002892

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.32721610
2	MP0005360_urolithiasis	7.71623384
3	MP0005085_abnormal_gallbladder_physiolo	6.52936567
4	MP0005365_abnormal_bile_salt	6.16776736
5	MP0008875_abnormal_xenobiotic_pharmacok	5.21181842
6	MP0003806_abnormal_nucleotide_metabolis	4.30695691
7	MP0003252_abnormal_bile_duct	3.98376023
8	MP0003183_abnormal_peptide_metabolism	3.59529565
9	MP0010329_abnormal_lipoprotein_level	3.57265600
10	MP0009840_abnormal_foam_cell	3.20866931
11	MP0004264_abnormal_extraembryonic_tissu	3.04341030
12	MP0005083_abnormal_biliary_tract	3.02494907
13	MP0003195_calcinosis	2.78307318
14	MP0005332_abnormal_amino_acid	2.75222543
15	MP0001666_abnormal_nutrient_absorption	2.67846419
16	MP0004147_increased_porphyrin_level	2.65276205
17	MP0004019_abnormal_vitamin_homeostasis	2.14616141
18	MP0000609_abnormal_liver_physiology	2.14405420
19	MP0003191_abnormal_cellular_cholesterol	2.12979067
20	MP0002118_abnormal_lipid_homeostasis	2.08755960
21	MP0003868_abnormal_feces_composition	1.96455393
22	MP0002138_abnormal_hepatobiliary_system	1.94090637
23	MP0005409_darkened_coat_color	1.85579511
24	MP0005319_abnormal_enzyme/_coenzyme	1.82545822
25	MP0001764_abnormal_homeostasis	1.70045871
26	MP0009697_abnormal_copulation	1.65409323
27	MP0005584_abnormal_enzyme/coenzyme_acti	1.55660253
28	MP0010155_abnormal_intestine_physiology	1.53750281
29	MP0001664_abnormal_digestion	1.47335468
30	MP0003866_abnormal_defecation	1.47195085
31	MP0005451_abnormal_body_composition	1.39663713
32	MP0009379_abnormal_foot_pigmentation	1.36832896
33	MP0003011_delayed_dark_adaptation	1.31076445
34	MP0003186_abnormal_redox_activity	1.25774284
35	MP0004043_abnormal_pH_regulation	1.23568157
36	MP0009643_abnormal_urine_homeostasis	1.21576227
37	MP0003656_abnormal_erythrocyte_physiolo	1.21147760
38	MP0001765_abnormal_ion_homeostasis	1.20373147
39	MP0000598_abnormal_liver_morphology	1.16364900
40	MP0005647_abnormal_sex_gland	1.13256775
41	MP0003705_abnormal_hypodermis_morpholog	1.13199741
42	MP0000566_synostosis	1.10909811
43	MP0000477_abnormal_intestine_morphology	1.08490504
44	MP0000538_abnormal_urinary_bladder	1.08431468
45	MP0009764_decreased_sensitivity_to	1.04064444
46	MP0000604_amyloidosis	1.02041056
47	MP0003879_abnormal_hair_cell	1.02021366
48	MP0002254_reproductive_system_inflammat	1.00327539
49	MP0009763_increased_sensitivity_to	1.00302439
50	MP0010352_gastrointestinal_tract_polyps	0.92717876
51	MP0010368_abnormal_lymphatic_system	0.89589325
52	MP0005636_abnormal_mineral_homeostasis	0.89187590
53	MP0003122_maternal_imprinting	0.88956934
54	MP0003300_gastrointestinal_ulcer	0.87632417
55	MP0008469_abnormal_protein_level	0.87053472
56	MP0002089_abnormal_postnatal_growth/wei	0.86096706
57	MP0005408_hypopigmentation	0.85637230
58	MP0009642_abnormal_blood_homeostasis	0.85551567
59	MP0000490_abnormal_crypts_of	0.83677228
60	MP0005058_abnormal_lysosome_morphology	0.83520316
61	MP0006036_abnormal_mitochondrial_physio	0.80694594
62	MP0005084_abnormal_gallbladder_morpholo	0.80162162
63	MP0005376_homeostasis/metabolism_phenot	0.79898872
64	MP0005670_abnormal_white_adipose	0.79037479
65	MP0009765_abnormal_xenobiotic_induced	0.78338056
66	MP0002876_abnormal_thyroid_physiology	0.77283944
67	MP0002078_abnormal_glucose_homeostasis	0.76354443
68	MP0001873_stomach_inflammation	0.73609631
69	MP0005220_abnormal_exocrine_pancreas	0.72595656
70	MP0006054_spinal_hemorrhage	0.72046168
71	MP0002971_abnormal_brown_adipose	0.70387759
72	MP0009780_abnormal_chondrocyte_physiolo	0.69806653
73	MP0004270_analgesia	0.69607991
74	MP0004130_abnormal_muscle_cell	0.69070647
75	MP0000678_abnormal_parathyroid_gland	0.68427410
76	MP0005334_abnormal_fat_pad	0.68182775
77	MP0005535_abnormal_body_temperature	0.67516800
78	MP0005266_abnormal_metabolism	0.66881306
79	MP0000462_abnormal_digestive_system	0.66200127
80	MP0003690_abnormal_glial_cell	0.66006554
81	MP0009053_abnormal_anal_canal	0.65107949
82	MP0001663_abnormal_digestive_system	0.63339016
83	MP0001661_extended_life_span	0.63291128
84	MP0008004_abnormal_stomach_pH	0.62136539
85	MP0003329_amyloid_beta_deposits	0.59910915
86	MP0000639_abnormal_adrenal_gland	0.58021730
87	MP0001501_abnormal_sleep_pattern	0.56378155
88	MP0002166_altered_tumor_susceptibility	0.55475181
89	MP0005448_abnormal_energy_balance	0.55441306
90	MP0001756_abnormal_urination	0.55357239
91	MP0006035_abnormal_mitochondrial_morpho	0.55158515
92	MP0002822_catalepsy	0.51830822
93	MP0005381_digestive/alimentary_phenotyp	0.50494154
94	MP0002396_abnormal_hematopoietic_system	0.48830691
95	MP0005464_abnormal_platelet_physiology	0.47791362
96	MP0002098_abnormal_vibrissa_morphology	0.47453050
97	MP0002928_abnormal_bile_duct	0.46812808
98	MP0003718_maternal_effect	0.46656326
99	MP0003638_abnormal_response/metabolism_	0.45766032
100	MP0005395_other_phenotype	0.45319128
101	MP0008874_decreased_physiological_sensi	0.45296827
102	MP0008873_increased_physiological_sensi	0.45230141
103	MP0009785_altered_susceptibility_to	0.44812876
104	MP0002136_abnormal_kidney_physiology	0.43118768
105	MP0002896_abnormal_bone_mineralization	0.43081952
106	MP0004381_abnormal_hair_follicle	0.42688055
107	MP0004782_abnormal_surfactant_physiolog	0.42396120
108	MP0005248_abnormal_Harderian_gland	0.40575907
109	MP0003724_increased_susceptibility_to	0.40293082
110	MP0004272_abnormal_basement_membrane	0.40002146
111	MP0003436_decreased_susceptibility_to	0.39809876
112	MP0003953_abnormal_hormone_level	0.39670877
113	MP0002837_dystrophic_cardiac_calcinosis	0.39284780
114	MP0006138_congestive_heart_failure	0.39279028
115	MP0005166_decreased_susceptibility_to	0.39131358
116	MP0008872_abnormal_physiological_respon	0.39053837
117	MP0001188_hyperpigmentation	0.38851553
118	MP0003075_altered_response_to	0.38573606
119	MP0002135_abnormal_kidney_morphology	0.37500665
120	MP0000579_abnormal_nail_morphology	0.37385100
121	MP0009672_abnormal_birth_weight	0.36409934
122	MP0005666_abnormal_adipose_tissue	0.35863092
123	MP0009384_cardiac_valve_regurgitation	0.35391146
124	MP0002796_impaired_skin_barrier	0.33914257
125	MP0003941_abnormal_skin_development	0.33073857
126	MP0010386_abnormal_urinary_bladder	0.32827613
127	MP0009115_abnormal_fat_cell	0.32152745
128	MP0000230_abnormal_systemic_arterial	0.31855964
129	MP0006082_CNS_inflammation	0.30267364
130	MP0001243_abnormal_dermal_layer	0.29996516
131	MP0000249_abnormal_blood_vessel	0.29884569
132	MP0002970_abnormal_white_adipose	0.28851250
133	MP0001853_heart_inflammation	0.28833620
134	MP0001881_abnormal_mammary_gland	0.28350630
135	MP0002168_other_aberrant_phenotype	0.27226800
136	MP0001845_abnormal_inflammatory_respons	0.26649482
137	MP0004883_abnormal_blood_vessel	0.26249135
138	MP0002090_abnormal_vision	0.25572929
139	MP0002060_abnormal_skin_morphology	0.25310732
140	MP0002132_abnormal_respiratory_system	0.23524314
141	MP0010234_abnormal_vibrissa_follicle	0.23027442

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intrahepatic cholestasis (HP:0001406)	7.49021866
2	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.42017558
3	Deep venous thrombosis (HP:0002625)	7.40370439
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.77583014
5	Hypobetalipoproteinemia (HP:0003563)	6.56951055
6	Prolonged partial thromboplastin time (HP:0003645)	6.55806362
7	Xanthomatosis (HP:0000991)	6.32661894
8	Hyperlipoproteinemia (HP:0010980)	5.53912590
9	Complement deficiency (HP:0004431)	5.51060439
10	Hypolipoproteinemia (HP:0010981)	4.80226703
11	Joint hemorrhage (HP:0005261)	4.72152778
12	Epidermoid cyst (HP:0200040)	4.67118096
13	Hyperammonemia (HP:0001987)	4.63597826
14	Hyperglycinemia (HP:0002154)	4.44819777
15	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.40222898
16	Abnormality of the common coagulation pathway (HP:0010990)	4.36498974
17	Abnormality of methionine metabolism (HP:0010901)	4.31288451
18	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.28641006
19	Fat malabsorption (HP:0002630)	4.26918651
20	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.26569374
21	Ketosis (HP:0001946)	4.23488915
22	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.18548796
23	Hypoalphalipoproteinemia (HP:0003233)	4.08008887
24	Abnormality of complement system (HP:0005339)	4.02225738
25	Abnormality of the vitamin B12 metabolism (HP:0004341)	4.01928132
26	Ileus (HP:0002595)	3.98310799
27	Hyperglycinuria (HP:0003108)	3.95738696
28	Abnormality of serine family amino acid metabolism (HP:0010894)	3.93920516
29	Abnormality of glycine metabolism (HP:0010895)	3.93920516
30	Abnormality of pyrimidine metabolism (HP:0004353)	3.91421092
31	Conjugated hyperbilirubinemia (HP:0002908)	3.85208290
32	Widely patent fontanelles and sutures (HP:0004492)	3.83666669
33	Hypoglycemic coma (HP:0001325)	3.79842111
34	Abnormality of vitamin B metabolism (HP:0004340)	3.78792227
35	Abnormality of the intrinsic pathway (HP:0010989)	3.76748528
36	Hypercholesterolemia (HP:0003124)	3.67679718
37	Pigmentary retinal degeneration (HP:0001146)	3.67316480
38	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.38197457
39	Hyperbilirubinemia (HP:0002904)	3.36822319
40	Chronic diarrhea (HP:0002028)	3.33551934
41	Abnormality of fatty-acid metabolism (HP:0004359)	3.30628846
42	Facial shape deformation (HP:0011334)	3.24037018
43	Potter facies (HP:0002009)	3.24037018
44	Glycosuria (HP:0003076)	3.23216054
45	Abnormality of urine glucose concentration (HP:0011016)	3.23216054
46	Steatorrhea (HP:0002570)	3.21048824
47	Flat acetabular roof (HP:0003180)	3.13055767
48	Abnormality of serum amino acid levels (HP:0003112)	3.12242354
49	Delayed CNS myelination (HP:0002188)	3.11063377
50	Abnormality of nucleobase metabolism (HP:0010932)	3.08555923
51	Proximal tubulopathy (HP:0000114)	3.06956992
52	Confusion (HP:0001289)	3.01977012
53	Ketoacidosis (HP:0001993)	3.00407922
54	Hepatocellular carcinoma (HP:0001402)	2.97617427
55	Hyperactive renin-angiotensin system (HP:0000841)	2.97155954
56	Myocardial infarction (HP:0001658)	2.95052292
57	Hypochromic microcytic anemia (HP:0004840)	2.93780775
58	Skin nodule (HP:0200036)	2.88205291
59	Wide cranial sutures (HP:0010537)	2.83809741
60	Spontaneous abortion (HP:0005268)	2.83282955
61	Megaloblastic anemia (HP:0001889)	2.80443744
62	Abnormal tarsal ossification (HP:0008369)	2.77520197
63	Metabolic acidosis (HP:0001942)	2.76009107
64	Systemic lupus erythematosus (HP:0002725)	2.75585888
65	Acanthocytosis (HP:0001927)	2.69246042
66	Abnormality of purine metabolism (HP:0004352)	2.67123338
67	Lethargy (HP:0001254)	2.61668516
68	Metabolic alkalosis (HP:0200114)	2.56464574
69	Vascular calcification (HP:0004934)	2.54477785
70	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.54457636
71	Dicarboxylic aciduria (HP:0003215)	2.54457636
72	Abnormality of carpal bone ossification (HP:0006257)	2.51835681
73	Right ventricular cardiomyopathy (HP:0011663)	2.51084967
74	Spastic diplegia (HP:0001264)	2.49973088
75	Thin bony cortex (HP:0002753)	2.49757299
76	Nephrolithiasis (HP:0000787)	2.49156700
77	Abnormal gallbladder morphology (HP:0012437)	2.48977969
78	Abdominal distention (HP:0003270)	2.47847572
79	Nausea (HP:0002018)	2.46801493
80	Abnormal urine phosphate concentration (HP:0012599)	2.45929661
81	Cerebral edema (HP:0002181)	2.44808009
82	Recurrent gram-negative bacterial infections (HP:0005420)	2.43746969
83	Hypoglycemic seizures (HP:0002173)	2.43327705
84	Hyperphosphaturia (HP:0003109)	2.42751097
85	Cholelithiasis (HP:0001081)	2.41601580
86	Hypophosphatemia (HP:0002148)	2.41025249
87	Gout (HP:0001997)	2.39628830
88	Mitral stenosis (HP:0001718)	2.39424580
89	Glomerulonephritis (HP:0000099)	2.39150385
90	Neonatal onset (HP:0003623)	2.38258804
91	Abnormal gallbladder physiology (HP:0012438)	2.36635797
92	Cholecystitis (HP:0001082)	2.36635797
93	Irritability (HP:0000737)	2.35838541
94	Focal segmental glomerulosclerosis (HP:0000097)	2.30067661
95	Malnutrition (HP:0004395)	2.28218931
96	Hypotension (HP:0002615)	2.25614089
97	Cardiovascular calcification (HP:0011915)	2.25410615
98	Increased purine levels (HP:0004368)	2.21754699
99	Hyperuricemia (HP:0002149)	2.21754699
100	Osteomalacia (HP:0002749)	2.18348307
101	Esophageal varix (HP:0002040)	2.17089144
102	Sensorimotor neuropathy (HP:0007141)	2.14951529
103	Amyloidosis (HP:0011034)	2.14301330
104	Pancreatitis (HP:0001733)	2.13131643
105	Brushfield spots (HP:0001088)	2.11837650
106	Menorrhagia (HP:0000132)	2.09763596
107	Gingival bleeding (HP:0000225)	2.09576793
108	Late onset (HP:0003584)	2.08309486
109	Enlarged kidneys (HP:0000105)	2.06673688
110	Abnormality of renin-angiotensin system (HP:0000847)	2.06173544
111	Poikilocytosis (HP:0004447)	2.04854688
112	Vomiting (HP:0002013)	2.04702009
113	Decreased circulating renin level (HP:0003351)	2.03346044
114	Abnormality of the gallbladder (HP:0005264)	2.02218814
115	Opisthotonus (HP:0002179)	2.01392109
116	Generalized aminoaciduria (HP:0002909)	1.99909480
117	Thrombophlebitis (HP:0004418)	1.99313548
118	Glomerulosclerosis (HP:0000096)	1.98836639
119	Metaphyseal irregularity (HP:0003025)	1.98661374
120	Hyperinsulinemic hypoglycemia (HP:0000825)	1.97041694
121	Hemorrhage of the eye (HP:0011885)	1.95251322
122	Rickets (HP:0002748)	1.93180603
123	Abnormal hand bone ossification (HP:0010660)	1.93140471
124	Delayed epiphyseal ossification (HP:0002663)	1.91536458
125	Abnormal cartilage morphology (HP:0002763)	1.90029327
126	Abnormality of proline metabolism (HP:0010907)	1.89331801
127	Hydroxyprolinuria (HP:0003080)	1.89331801
128	Renal cortical cysts (HP:0000803)	1.86444331
129	Abnormality of iron homeostasis (HP:0011031)	1.85696602
130	Abnormality of transition element cation homeostasis (HP:0011030)	1.84382510
131	Abnormal enzyme/coenzyme activity (HP:0012379)	1.83887907
132	Alkalosis (HP:0001948)	1.83364083
133	Abnormal ossification of hand bones (HP:0005921)	1.83048128
134	Enlarged epiphyses (HP:0010580)	1.82160892
135	Hypophosphatemic rickets (HP:0004912)	1.81385847
136	Abnormality of vitamin metabolism (HP:0100508)	1.80996368
137	Elevated hepatic transaminases (HP:0002910)	1.80984008
138	Renal tubular acidosis (HP:0001947)	1.80922357
139	Abnormal foot bone ossification (HP:0010675)	1.80463547
140	Renal tubular dysfunction (HP:0000124)	1.79619652
141	Status epilepticus (HP:0002133)	1.78642011
142	Rectal prolapse (HP:0002035)	1.76430286
143	Hyperglycemia (HP:0003074)	1.75156067
144	Abnormality of alkaline phosphatase activity (HP:0004379)	1.73235624
145	Abnormality of small intestinal villus morphology (HP:0011472)	1.72923771
146	Nephritis (HP:0000123)	1.70796596

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	7.09508529
2	ACVR1B	6.52729940
3	SIK1	4.58331479
4	FGFR4	4.47220610
5	ERN1	4.15075895
6	STK39	3.67205917
7	TAOK3	3.14807940
8	ERBB4	3.12762880
9	INSRR	3.00864937
10	LMTK2	2.90815490
11	EPHA2	2.88370832
12	PRKG2	2.82484901
13	MAP2K4	2.36495160
14	OXSR1	2.35572266
15	PKN2	2.28548685
16	MST1R	2.27084562
17	FLT3	1.95761446
18	MAPK11	1.94693550
19	PDK2	1.91684400
20	PIK3CG	1.75908913
21	LATS1	1.69847307
22	TYK2	1.66707300
23	FRK	1.66102771
24	MAP3K12	1.65441992
25	TRIB3	1.61564715
26	WNK4	1.54692066
27	ABL2	1.51258059
28	PTK6	1.46658508
29	FGFR2	1.46309851
30	DAPK2	1.44977638
31	NEK9	1.37741353
32	DDR2	1.30607874
33	MAP3K7	1.27043622
34	KDR	1.24688972
35	JAK2	1.23976009
36	PDGFRA	1.21324141
37	GRK6	1.15932490
38	STK24	1.15593308
39	PRKAA2	1.15099588
40	PINK1	1.13354150
41	MAP3K10	1.09670887
42	ERBB2	1.08680800
43	TBK1	1.06829514
44	NLK	1.04709918
45	MAP3K14	1.04348591
46	MAP2K3	1.02859583
47	MAPK4	1.01000440
48	JAK1	1.00036841
49	MYLK	0.97285876
50	PRKCZ	0.94104269
51	MET	0.90139621
52	STK38L	0.88041316
53	MAPK15	0.87996772
54	MAP3K1	0.86928143
55	MAP3K3	0.86853082
56	MATK	0.85935061
57	FGFR1	0.84917298
58	TESK2	0.83498647
59	CDK6	0.83230762
60	MST4	0.81590195
61	MAPK12	0.77794037
62	FER	0.76222291
63	EPHB1	0.76040403
64	PRKACG	0.75799165
65	TYRO3	0.74961298
66	CAMK2G	0.74578297
67	MAP3K11	0.73874527
68	TNIK	0.73438992
69	MAP2K6	0.73301886
70	TIE1	0.71273294
71	RIPK1	0.70059634
72	IRAK3	0.69583361
73	CSK	0.69423378
74	EPHA3	0.68152870
75	CDC42BPA	0.68031614
76	PRKAA1	0.66756100
77	GSK3A	0.66207090
78	CAMK1D	0.66150664
79	DYRK1B	0.65725022
80	SGK3	0.63594442
81	CASK	0.61108965
82	CDK12	0.60978572
83	BCR	0.60966674
84	YES1	0.58976928
85	MAPK7	0.58619271
86	FGFR3	0.57333624
87	CSF1R	0.55970639
88	IKBKE	0.55327464
89	PRKCQ	0.54619118
90	EEF2K	0.53828804
91	PTK2	0.52967300
92	CSNK1G1	0.52588085
93	SRC	0.51947011
94	TGFBR2	0.51663772
95	PDPK1	0.50381383
96	EPHA4	0.50081133
97	GRK1	0.47554127
98	TAOK2	0.46962531
99	IGF1R	0.45993915
100	MAP3K5	0.45372440
101	SGK2	0.45353782
102	PKN1	0.45113791
103	PBK	0.43989299
104	RET	0.43649363
105	MAP2K1	0.42424954
106	MAP3K13	0.42418705
107	CDK4	0.40192585
108	PRKCG	0.38340643
109	MAPKAPK3	0.36369022
110	ICK	0.36123157
111	MAP3K6	0.35113780
112	EGFR	0.35007439
113	MELK	0.34680610
114	WNK1	0.33650089
115	RPS6KB1	0.33095174
116	BRSK2	0.32709985
117	CSNK1G2	0.32606451
118	MTOR	0.32143263
119	NEK6	0.31815310
120	PDK1	0.31609786
121	CAMK4	0.30976789
122	SGK223	0.30744072
123	SGK494	0.30744072
124	PIM1	0.30618121
125	ITK	0.30274500
126	IRAK2	0.29312027
127	FYN	0.28892147
128	CSNK1G3	0.28845156
129	PIK3CA	0.27922866
130	PRKCA	0.27049936
131	BMPR2	0.26734945
132	PRKG1	0.26680164
133	PRKCD	0.25675253
134	FGR	0.25653065
135	SGK1	0.25172173
136	MAP3K2	0.25140541
137	AKT3	0.24991840
138	PDK3	0.24168154
139	PDK4	0.24168154
140	IRAK1	0.24022963
141	LATS2	0.23966273
142	MAP2K2	0.23601694
143	EPHB2	0.23499285
144	ABL1	0.22925463
145	STK3	0.21478893
146	CSNK1E	0.20352240
147	CAMK2D	0.20217996
148	KSR2	0.19901014

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.65284819
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.66275552
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.41608591
4	* Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.17796002
5	Arginine biosynthesis_Homo sapiens_hsa00220	3.13291502
6	Complement and coagulation cascades_Homo sapiens_hsa04610	2.75501208
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.74361107
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.66315282
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.62884075
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.55254048
11	Fatty acid degradation_Homo sapiens_hsa00071	2.48987572
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.38727338
13	Butanoate metabolism_Homo sapiens_hsa00650	2.14873865
14	Peroxisome_Homo sapiens_hsa04146	2.09956535
15	Protein digestion and absorption_Homo sapiens_hsa04974	2.09735117
16	* Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.08330402
17	* Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.07808113
18	Mineral absorption_Homo sapiens_hsa04978	2.04425255
19	Histidine metabolism_Homo sapiens_hsa00340	1.93977160
20	Propanoate metabolism_Homo sapiens_hsa00640	1.92533338
21	Caffeine metabolism_Homo sapiens_hsa00232	1.89916024
22	* Chemical carcinogenesis_Homo sapiens_hsa05204	1.88650791
23	PPAR signaling pathway_Homo sapiens_hsa03320	1.86875807
24	* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.86141440
25	* Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.86098041
26	Fatty acid metabolism_Homo sapiens_hsa01212	1.77583332
27	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.76776945
28	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.73153372
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.72319556
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.71286444
31	* Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.64664727
32	* Retinol metabolism_Homo sapiens_hsa00830	1.61290341
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.60930663
34	Phenylalanine metabolism_Homo sapiens_hsa00360	1.58982012
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.55206141
36	Bile secretion_Homo sapiens_hsa04976	1.53449037
37	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.52444626
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.50056013
39	Tyrosine metabolism_Homo sapiens_hsa00350	1.45861520
40	Sulfur metabolism_Homo sapiens_hsa00920	1.40189158
41	Pyruvate metabolism_Homo sapiens_hsa00620	1.36271971
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.32719937
43	Fatty acid elongation_Homo sapiens_hsa00062	1.31557776
44	Folate biosynthesis_Homo sapiens_hsa00790	1.24906572
45	ABC transporters_Homo sapiens_hsa02010	1.22120972
46	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.21935536
47	Fat digestion and absorption_Homo sapiens_hsa04975	1.21676234
48	Steroid biosynthesis_Homo sapiens_hsa00100	1.20719696
49	* Starch and sucrose metabolism_Homo sapiens_hsa00500	1.19783805
50	Carbon metabolism_Homo sapiens_hsa01200	1.13406623
51	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.08423278
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03221591
53	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.99664106
54	Arginine and proline metabolism_Homo sapiens_hsa00330	0.97485638
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.95705510
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.93621398
57	Sulfur relay system_Homo sapiens_hsa04122	0.93396217
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.89514672
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.87928204
60	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.85786241
61	Lysine degradation_Homo sapiens_hsa00310	0.81534337
62	* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.77354916
63	Pancreatic secretion_Homo sapiens_hsa04972	0.76255574
64	One carbon pool by folate_Homo sapiens_hsa00670	0.75486745
65	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.71306517
66	Sphingolipid metabolism_Homo sapiens_hsa00600	0.71098718
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68294516
68	Glutathione metabolism_Homo sapiens_hsa00480	0.67489915
69	Other glycan degradation_Homo sapiens_hsa00511	0.65245872
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58971606
71	Pentose phosphate pathway_Homo sapiens_hsa00030	0.57734408
72	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54333012
73	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.48836844
74	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.47131347
75	* Metabolic pathways_Homo sapiens_hsa01100	0.46394526
76	Prion diseases_Homo sapiens_hsa05020	0.40949569
77	Galactose metabolism_Homo sapiens_hsa00052	0.29323823
78	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.24992136
79	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.23571210
80	Insulin resistance_Homo sapiens_hsa04931	0.23155265
81	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.22524560
82	Linoleic acid metabolism_Homo sapiens_hsa00591	0.22344938
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.21500478
84	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.21426313
85	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.18710504
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.16059115
87	Pertussis_Homo sapiens_hsa05133	0.15465747
88	Renin secretion_Homo sapiens_hsa04924	0.11447987
89	Glucagon signaling pathway_Homo sapiens_hsa04922	0.09248133
90	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.08071093
91	Tight junction_Homo sapiens_hsa04530	0.02954485
92	AMPK signaling pathway_Homo sapiens_hsa04152	0.01489658
93	Ether lipid metabolism_Homo sapiens_hsa00565	-0.2501469
94	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	-0.2456422
95	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	-0.2378722
96	Amoebiasis_Homo sapiens_hsa05146	-0.2209372
97	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.2110261
98	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.2014535
99	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.1886993
100	Hepatitis C_Homo sapiens_hsa05160	-0.1790214
101	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.1727169
102	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.1649966
103	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.1636587
104	African trypanosomiasis_Homo sapiens_hsa05143	-0.1472750
105	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1463017
106	Regulation of autophagy_Homo sapiens_hsa04140	-0.1366719
107	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.1342999
108	Renin-angiotensin system_Homo sapiens_hsa04614	-0.1266979
109	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.1041349
110	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1027883
111	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0696468
112	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0678670
113	Leukocyte transendothelial migration_Homo sapiens_hsa04670	-0.0591556
114	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0421651
115	Intestinal immune network for IgA production_Homo sapiens_hsa04672	-0.0367024

UGT2A3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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