ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of fibrinolysis (GO:0051918)	9.02378852
2	regulation of fibrinolysis (GO:0051917)	8.95944279
3	regulation of protein activation cascade (GO:2000257)	8.07388517
4	regulation of complement activation (GO:0030449)	7.75076450
5	L-phenylalanine catabolic process (GO:0006559)	7.68350853
6	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.68350853
7	complement activation, alternative pathway (GO:0006957)	7.66370712
8	epoxygenase P450 pathway (GO:0019373)	7.30298356
9	exogenous drug catabolic process (GO:0042738)	7.15703652
10	protein carboxylation (GO:0018214)	7.13140750
11	peptidyl-glutamic acid carboxylation (GO:0017187)	7.13140750
12	ethanol oxidation (GO:0006069)	7.09787896
13	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.09323441
14	L-phenylalanine metabolic process (GO:0006558)	7.09323441
15	omega-hydroxylase P450 pathway (GO:0097267)	6.88461991
16	blood coagulation, intrinsic pathway (GO:0007597)	6.63642405
17	drug catabolic process (GO:0042737)	6.59254937
18	glyoxylate metabolic process (GO:0046487)	6.48705788
19	fibrinolysis (GO:0042730)	6.13714527
20	ethanol metabolic process (GO:0006067)	5.74177433
21	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.66362087
22	regulation of plasminogen activation (GO:0010755)	5.62782511
23	very-low-density lipoprotein particle assembly (GO:0034379)	5.56605516
24	negative regulation of sterol transport (GO:0032372)	5.55511002
25	negative regulation of cholesterol transport (GO:0032375)	5.55511002
26	aromatic amino acid family catabolic process (GO:0009074)	5.35687169
27	urea metabolic process (GO:0019627)	5.33768227
28	intestinal cholesterol absorption (GO:0030299)	5.32813287
29	plasma lipoprotein particle remodeling (GO:0034369)	5.29305604
30	protein-lipid complex remodeling (GO:0034368)	5.29305604
31	macromolecular complex remodeling (GO:0034367)	5.29305604
32	cholesterol efflux (GO:0033344)	5.28915598
33	cellular glucuronidation (GO:0052695)	5.21793958
34	imidazole-containing compound metabolic process (GO:0052803)	5.15993949
35	protein activation cascade (GO:0072376)	5.14730806
36	negative regulation of protein activation cascade (GO:2000258)	5.09698718
37	plasma lipoprotein particle assembly (GO:0034377)	5.00765690
38	high-density lipoprotein particle remodeling (GO:0034375)	4.95089579
39	regulation of cholesterol esterification (GO:0010872)	4.94606471
40	glucuronate metabolic process (GO:0019585)	4.92515778
41	uronic acid metabolic process (GO:0006063)	4.92515778
42	negative regulation of blood coagulation (GO:0030195)	4.85646771
43	negative regulation of hemostasis (GO:1900047)	4.85646771
44	drug metabolic process (GO:0017144)	4.83293165
45	nitrogen cycle metabolic process (GO:0071941)	4.82835691
46	low-density lipoprotein particle remodeling (GO:0034374)	4.76546341
47	regulation of humoral immune response (GO:0002920)	4.72706857
48	complement activation, classical pathway (GO:0006958)	4.72493664
49	bile acid biosynthetic process (GO:0006699)	4.72266839
50	serine family amino acid catabolic process (GO:0009071)	4.67439370
51	regulation of apoptotic cell clearance (GO:2000425)	4.65225871
52	bile acid metabolic process (GO:0008206)	4.58354019
53	urea cycle (GO:0000050)	4.56546430
54	glutamate metabolic process (GO:0006536)	4.56469679
55	complement activation (GO:0006956)	4.56090107
56	reverse cholesterol transport (GO:0043691)	4.53102695
57	positive regulation of blood coagulation (GO:0030194)	4.49311220
58	positive regulation of hemostasis (GO:1900048)	4.49311220
59	acute-phase response (GO:0006953)	4.46506591
60	plasma lipoprotein particle organization (GO:0071827)	4.45609464
61	protein-lipid complex assembly (GO:0065005)	4.44483370
62	negative regulation of coagulation (GO:0050819)	4.43377159
63	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.39756230
64	triglyceride homeostasis (GO:0070328)	4.37813307
65	acylglycerol homeostasis (GO:0055090)	4.37813307
66	positive regulation of lipoprotein lipase activity (GO:0051006)	4.37188394
67	positive regulation of triglyceride lipase activity (GO:0061365)	4.37188394
68	phospholipid efflux (GO:0033700)	4.35140722
69	oxidative demethylation (GO:0070989)	4.31793227
70	negative regulation of wound healing (GO:0061045)	4.30285396
71	glycine metabolic process (GO:0006544)	4.27023081
72	plasma lipoprotein particle clearance (GO:0034381)	4.26918855
73	negative regulation of complement activation (GO:0045916)	4.22503963
74	tyrosine metabolic process (GO:0006570)	4.19589685
75	protein-lipid complex subunit organization (GO:0071825)	4.18252818
76	cytolysis (GO:0019835)	4.13775350
77	positive regulation of coagulation (GO:0050820)	4.11460878
78	bile acid and bile salt transport (GO:0015721)	4.09796114
79	regulation of triglyceride catabolic process (GO:0010896)	4.06590868
80	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	4.00505911
81	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	4.00505911
82	negative regulation of lipase activity (GO:0060192)	3.84537677
83	phenylpropanoid metabolic process (GO:0009698)	3.84280207
84	alpha-amino acid catabolic process (GO:1901606)	3.68786560
85	opsonization (GO:0008228)	3.67132653
86	lipoprotein metabolic process (GO:0042157)	3.59203602
87	regulation of bile acid biosynthetic process (GO:0070857)	3.53669597
88	amino-acid betaine metabolic process (GO:0006577)	3.52988298
89	sodium-independent organic anion transport (GO:0043252)	3.49204925
90	serine family amino acid metabolic process (GO:0009069)	3.45079358
91	aromatic amino acid family metabolic process (GO:0009072)	3.43718536
92	proline metabolic process (GO:0006560)	3.43395809
93	intestinal absorption (GO:0050892)	3.41293895
94	cholesterol homeostasis (GO:0042632)	3.41163605
95	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.40103893
96	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.39719234
97	sterol transport (GO:0015918)	3.38403818
98	cholesterol transport (GO:0030301)	3.38403818
99	sterol homeostasis (GO:0055092)	3.36535839
100	S-adenosylmethionine metabolic process (GO:0046500)	3.34450649

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	6.99953476
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.04268866
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.92376681
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.80909263
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.79407644
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.68195237
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.07802244
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.96767514
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.73652905
10	* FOXA2_19822575_ChIP-Seq_HepG2_Human	3.53782734
11	* HNF4A_19822575_ChIP-Seq_HepG2_Human	2.96101833
12	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.74725845
13	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.29900941
14	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.7919059
15	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.98066760
16	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.80201034
17	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.72197248
18	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50865653
19	CLOCK_20551151_ChIP-Seq_293T_Human	1.45397367
20	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.34680873
21	GATA4_25053715_ChIP-Seq_YYC3_Human	1.31953274
22	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.28783993
23	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.27235019
24	HTT_18923047_ChIP-ChIP_STHdh_Human	1.24316748
25	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.17815538
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.14635140
27	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.14031481
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.10783844
29	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.07994289
30	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.07964587
31	ZNF263_19887448_ChIP-Seq_K562_Human	1.05331475
32	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.04571761
33	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.02543986
34	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.01894844
35	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.01545274
36	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.00546947
37	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.99859646
38	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.99805450
39	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.99589151
40	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.99371825
41	GATA6_25053715_ChIP-Seq_YYC3_Human	0.94987831
42	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.92844683
43	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.92377219
44	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.91025639
45	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.89699416
46	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.89379717
47	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.89195844
48	AR_21909140_ChIP-Seq_LNCAP_Human	0.84968773
49	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.80499656
50	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.80407410
51	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.78515517
52	* FOXA1_25552417_ChIP-Seq_VCAP_Human	0.78288874
53	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.77418836
54	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.76780574
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.75349758
56	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.75113211
57	CEBPB_22108803_ChIP-Seq_LS180_Human	0.73061244
58	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.71469440
59	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.71092751
60	SOX2_20726797_ChIP-Seq_SW620_Human	0.68850881
61	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.66534206
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.63963056
63	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.63778523
64	SOX2_21211035_ChIP-Seq_LN229_Human	0.63684079
65	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.63548091
66	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.63138792
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.63049254
68	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.62242759
69	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.61230448
70	LXR_22292898_ChIP-Seq_THP-1_Human	0.60782626
71	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.60583405
72	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.59797619
73	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.59211874
74	RAC3_21632823_ChIP-Seq_H3396_Human	0.58963895
75	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.57036218
76	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.55150646
77	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.54903047
78	TP53_16413492_ChIP-PET_HCT116_Human	0.54429845
79	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.54212907
80	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.54146349
81	MYC_19915707_ChIP-ChIP_AK7_Human	0.53030515
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.52981335
83	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.52468743
84	TP53_18474530_ChIP-ChIP_U2OS_Human	0.52383384
85	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.52286191
86	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.51702011
87	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.50947997
88	AR_20517297_ChIP-Seq_VCAP_Human	0.50824247
89	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.50081196
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.49597409
91	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.49337657
92	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.49221487
93	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.48548405
94	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.48499847
95	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.48124573
96	PU1_27457419_Chip-Seq_LIVER_Mouse	0.47353589
97	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.47126705
98	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.46785222
99	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.46516654
100	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.46242642

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	9.28835749
2	MP0005360_urolithiasis	6.27504960
3	MP0005085_abnormal_gallbladder_physiolo	5.76112178
4	MP0005365_abnormal_bile_salt	5.62541507
5	MP0008875_abnormal_xenobiotic_pharmacok	5.56824495
6	MP0003195_calcinosis	5.10347446
7	MP0003252_abnormal_bile_duct	3.92805773
8	MP0001666_abnormal_nutrient_absorption	3.79100805
9	MP0010329_abnormal_lipoprotein_level	3.51828132
10	MP0003868_abnormal_feces_composition	3.20948738
11	MP0002138_abnormal_hepatobiliary_system	2.83556863
12	MP0009697_abnormal_copulation	2.33014765
13	MP0005332_abnormal_amino_acid	2.24535153
14	MP0003122_maternal_imprinting	2.22776006
15	MP0010368_abnormal_lymphatic_system	2.10708419
16	MP0003806_abnormal_nucleotide_metabolis	2.05314243
17	MP0000609_abnormal_liver_physiology	1.98927253
18	MP0005408_hypopigmentation	1.84495407
19	MP0003191_abnormal_cellular_cholesterol	1.84030874
20	MP0002118_abnormal_lipid_homeostasis	1.80866841
21	MP0009840_abnormal_foam_cell	1.77365899
22	MP0002132_abnormal_respiratory_system	1.65721610
23	MP0002876_abnormal_thyroid_physiology	1.59682585
24	MP0001915_intracranial_hemorrhage	1.47485044
25	MP0005451_abnormal_body_composition	1.42406124
26	MP0001764_abnormal_homeostasis	1.39526287
27	MP0001661_extended_life_span	1.35127051
28	MP0003656_abnormal_erythrocyte_physiolo	1.30287402
29	MP0004019_abnormal_vitamin_homeostasis	1.17235573
30	MP0000598_abnormal_liver_morphology	1.17208554
31	MP0005319_abnormal_enzyme/_coenzyme	1.08941157
32	MP0000566_synostosis	1.07594741
33	MP0002089_abnormal_postnatal_growth/wei	1.01723729
34	MP0005058_abnormal_lysosome_morphology	1.01466867
35	MP0000604_amyloidosis	0.94282816
36	MP0005584_abnormal_enzyme/coenzyme_acti	0.94005900
37	MP0003123_paternal_imprinting	0.93609502
38	MP0009643_abnormal_urine_homeostasis	0.92425454
39	MP0005670_abnormal_white_adipose	0.92290426
40	MP0009642_abnormal_blood_homeostasis	0.91678144
41	MP0005464_abnormal_platelet_physiology	0.89813579
42	MP0003172_abnormal_lysosome_physiology	0.88421207
43	MP0005636_abnormal_mineral_homeostasis	0.87445945
44	MP0002282_abnormal_trachea_morphology	0.80790819
45	MP0002971_abnormal_brown_adipose	0.76117532
46	MP0009763_increased_sensitivity_to	0.75617143
47	MP0008469_abnormal_protein_level	0.74886103
48	MP0005376_homeostasis/metabolism_phenot	0.73162232
49	MP0003690_abnormal_glial_cell	0.66525890
50	MP0002078_abnormal_glucose_homeostasis	0.65953235
51	MP0003011_delayed_dark_adaptation	0.62549792
52	MP0005084_abnormal_gallbladder_morpholo	0.61500172
53	MP0005409_darkened_coat_color	0.60682215
54	MP0000639_abnormal_adrenal_gland	0.60555780
55	MP0003879_abnormal_hair_cell	0.59860637
56	MP0004272_abnormal_basement_membrane	0.57920618
57	MP0009053_abnormal_anal_canal	0.57535818
58	MP0005395_other_phenotype	0.54775376
59	MP0006054_spinal_hemorrhage	0.49283722
60	MP0005164_abnormal_response_to	0.48828017
61	MP0005220_abnormal_exocrine_pancreas	0.47657473
62	MP0002168_other_aberrant_phenotype	0.47627057
63	MP0005023_abnormal_wound_healing	0.47080255
64	MP0004883_abnormal_blood_vessel	0.46732765
65	MP0005167_abnormal_blood-brain_barrier	0.45420978
66	MP0009780_abnormal_chondrocyte_physiolo	0.45252077
67	MP0003638_abnormal_response/metabolism_	0.44069903
68	MP0005448_abnormal_energy_balance	0.43894435
69	MP0005334_abnormal_fat_pad	0.43291007
70	MP0009115_abnormal_fat_cell	0.43113188
71	MP0003186_abnormal_redox_activity	0.41906539
72	MP0003121_genomic_imprinting	0.41716858
73	MP0008872_abnormal_physiological_respon	0.41010154
74	MP0003953_abnormal_hormone_level	0.40264405
75	MP0005187_abnormal_penis_morphology	0.39043789
76	MP0003183_abnormal_peptide_metabolism	0.38607453
77	MP0002249_abnormal_larynx_morphology	0.38226374
78	MP0002933_joint_inflammation	0.38172175
79	MP0003632_abnormal_nervous_system	0.38132585
80	MP0001756_abnormal_urination	0.37846081
81	MP0005257_abnormal_intraocular_pressure	0.36947261
82	MP0000920_abnormal_myelination	0.36352090
83	MP0000249_abnormal_blood_vessel	0.35996969
84	MP0005535_abnormal_body_temperature	0.35670543
85	MP0003878_abnormal_ear_physiology	0.34790396
86	MP0005377_hearing/vestibular/ear_phenot	0.34790396
87	MP0003075_altered_response_to	0.34662931
88	MP0003567_abnormal_fetal_cardiomyocyte	0.33665089
89	MP0003329_amyloid_beta_deposits	0.32306610
90	MP0005266_abnormal_metabolism	0.31959755
91	MP0009764_decreased_sensitivity_to	0.31401666
92	MP0003941_abnormal_skin_development	0.30956520
93	MP0002909_abnormal_adrenal_gland	0.30650660
94	MP0001324_abnormal_eye_pigmentation	0.30230940
95	MP0004130_abnormal_muscle_cell	0.30071018
96	MP0002128_abnormal_blood_circulation	0.29382430
97	MP0003950_abnormal_plasma_membrane	0.28910599
98	MP0003115_abnormal_respiratory_system	0.28331848
99	MP0003633_abnormal_nervous_system	0.27829039
100	MP0002697_abnormal_eye_size	0.27701215

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	9.56514535
2	Complement deficiency (HP:0004431)	9.00244299
3	Abnormality of monocarboxylic acid metabolism (HP:0010996)	7.86365749
4	Hypobetalipoproteinemia (HP:0003563)	7.78489456
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.49578529
6	Abnormality of complement system (HP:0005339)	7.06667192
7	Joint hemorrhage (HP:0005261)	6.75593762
8	Conjugated hyperbilirubinemia (HP:0002908)	5.99802912
9	Systemic lupus erythematosus (HP:0002725)	5.67882325
10	Abnormality of the common coagulation pathway (HP:0010990)	5.62867247
11	Glomerulonephritis (HP:0000099)	5.51803236
12	Xanthomatosis (HP:0000991)	4.95426016
13	Hypolipoproteinemia (HP:0010981)	4.65944973
14	Hyperlipoproteinemia (HP:0010980)	4.47537996
15	Intrahepatic cholestasis (HP:0001406)	4.47182866
16	Spontaneous abortion (HP:0005268)	4.45072706
17	Recurrent gram-negative bacterial infections (HP:0005420)	4.09782132
18	Hypercholesterolemia (HP:0003124)	3.89790957
19	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.88170863
20	Abnormality of the intrinsic pathway (HP:0010989)	3.80806795
21	Nephritis (HP:0000123)	3.53237640
22	Epidermoid cyst (HP:0200040)	3.35618233
23	Menorrhagia (HP:0000132)	3.32317828
24	Hemorrhage of the eye (HP:0011885)	3.30229824
25	Fat malabsorption (HP:0002630)	3.23589250
26	Vascular calcification (HP:0004934)	3.18011416
27	Gingival bleeding (HP:0000225)	3.15458542
28	Hypoalphalipoproteinemia (HP:0003233)	3.08640743
29	Abnormality of pyrimidine metabolism (HP:0004353)	3.06566137
30	Mitral stenosis (HP:0001718)	2.97353647
31	Purpura (HP:0000979)	2.93449776
32	Hyperglycinemia (HP:0002154)	2.88821456
33	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.80464753
34	Cardiovascular calcification (HP:0011915)	2.79351122
35	Osteomalacia (HP:0002749)	2.75020510
36	Thrombophlebitis (HP:0004418)	2.72980389
37	Rickets (HP:0002748)	2.66393334
38	Abnormality of methionine metabolism (HP:0010901)	2.66157446
39	Acanthocytosis (HP:0001927)	2.64948526
40	Generalized aminoaciduria (HP:0002909)	2.53983185
41	Hepatocellular carcinoma (HP:0001402)	2.51720612
42	Hyperammonemia (HP:0001987)	2.48708705
43	Abnormality of glycine metabolism (HP:0010895)	2.46211306
44	Abnormality of serine family amino acid metabolism (HP:0010894)	2.46211306
45	Arthropathy (HP:0003040)	2.43701832
46	Hypophosphatemic rickets (HP:0004912)	2.40518273
47	Delayed CNS myelination (HP:0002188)	2.36776182
48	Abnormal tarsal ossification (HP:0008369)	2.34281154
49	Fair hair (HP:0002286)	2.32072483
50	Myocardial infarction (HP:0001658)	2.27964836
51	Pulmonary embolism (HP:0002204)	2.21586295
52	Abnormality of carpal bone ossification (HP:0006257)	2.19510797
53	Hyperglycinuria (HP:0003108)	2.16608514
54	Skin nodule (HP:0200036)	2.15561025
55	Hyperbilirubinemia (HP:0002904)	2.11340473
56	Poikilocytosis (HP:0004447)	2.07702767
57	Steatorrhea (HP:0002570)	2.02832002
58	Deep venous thrombosis (HP:0002625)	11.5767624
59	Enlarged kidneys (HP:0000105)	1.94210054
60	Increased serum pyruvate (HP:0003542)	1.93917982
61	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.91557252
62	Abnormality of serum amino acid levels (HP:0003112)	1.91520180
63	Abnormality of the Achilles tendon (HP:0005109)	1.90856478
64	Abnormality of nucleobase metabolism (HP:0010932)	1.87850036
65	Bifid scrotum (HP:0000048)	1.87329234
66	Hypoglycemic coma (HP:0001325)	1.86078990
67	Cholecystitis (HP:0001082)	1.85470051
68	Abnormal gallbladder physiology (HP:0012438)	1.85470051
69	Epistaxis (HP:0000421)	1.80480395
70	Reduced antithrombin III activity (HP:0001976)	1.77221306
71	Joint swelling (HP:0001386)	1.76583805
72	Flat acetabular roof (HP:0003180)	1.75404860
73	Pancreatic islet-cell hyperplasia (HP:0004510)	1.74807627
74	Hyperphosphaturia (HP:0003109)	1.73894319
75	Facial shape deformation (HP:0011334)	1.73043586
76	Potter facies (HP:0002009)	1.73043586
77	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.72667382
78	Abnormality of glycolysis (HP:0004366)	1.70838147
79	Cholelithiasis (HP:0001081)	1.64851646
80	Ketosis (HP:0001946)	1.63549219
81	Small epiphyses (HP:0010585)	1.62878926
82	Broad alveolar ridges (HP:0000187)	1.62877942
83	Hydroxyprolinuria (HP:0003080)	1.62761402
84	Abnormality of proline metabolism (HP:0010907)	1.62761402
85	Esophageal varix (HP:0002040)	1.60964190
86	Abnormal hand bone ossification (HP:0010660)	1.59978478
87	Abnormal gallbladder morphology (HP:0012437)	1.57028579
88	Abnormal ossification of hand bones (HP:0005921)	1.57017450
89	Glycosuria (HP:0003076)	1.56997830
90	Abnormality of urine glucose concentration (HP:0011016)	1.56997830
91	Neonatal hypoglycemia (HP:0001998)	1.56617654
92	Gangrene (HP:0100758)	1.56140565
93	Abnormality of the lumbar spine (HP:0100712)	1.55118788
94	Increased mean platelet volume (HP:0011877)	1.54412868
95	Abnormal delivery (HP:0001787)	1.54190850
96	Elevated alkaline phosphatase (HP:0003155)	1.52969331
97	Peritonitis (HP:0002586)	1.52536689
98	Increased serum ferritin (HP:0003281)	1.52226612
99	Blue irides (HP:0000635)	1.51088563
100	Abnormality of vitamin metabolism (HP:0100508)	1.50237354

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FGFR4	7.17532046
2	FGFR3	5.15905048
3	ICK	3.37693567
4	ERN1	3.14898540
5	PIK3CA	3.10350138
6	CDK12	2.83804154
7	WNK4	2.72500313
8	RIPK1	2.48261339
9	FGFR2	2.25374870
10	TRIB3	2.19787586
11	TYRO3	2.12753884
12	AKT3	2.03306510
13	FGFR1	1.98453219
14	PDGFRA	1.87594079
15	PRKAA2	1.72900727
16	LATS1	1.70675735
17	TYK2	1.62008542
18	SIK1	1.57521165
19	TGFBR2	1.54977481
20	RET	1.53604199
21	MAPK11	1.53325811
22	PKN2	1.51939253
23	EIF2AK1	1.37830200
24	DYRK1B	1.37320687
25	WNK1	1.35441853
26	NEK9	1.34779680
27	PDPK1	1.32384875
28	SIK2	1.29004061
29	PRKACG	1.19206602
30	MAP3K2	1.17837732
31	ERBB2	1.17452177
32	SGK223	1.05312092
33	SGK494	1.05312092
34	PDK1	1.03798986
35	NTRK3	0.99389063
36	EEF2K	0.96480027
37	DDR2	0.96176856
38	EPHA4	0.88557647
39	SGK3	0.87828296
40	IGF1R	0.83180402
41	BCR	0.82113856
42	EPHA3	0.80237280
43	CSF1R	0.79801061
44	SGK1	0.79059694
45	CSNK1E	0.78748855
46	MAP2K4	0.78578132
47	SGK2	0.77964248
48	MAPKAPK3	0.77879495
49	RPS6KB1	0.75507607
50	PRKAA1	0.74654273
51	BCKDK	0.74327957
52	CDK7	0.73234205
53	IRAK3	0.70582572
54	FGR	0.70407154
55	LATS2	0.69336404
56	PRKCZ	0.66618724
57	CAMK1D	0.66275407
58	CDC42BPA	0.64429459
59	MST1R	0.62074037
60	PRKCG	0.61952576
61	MAP3K3	0.61456808
62	BRSK2	0.61110278
63	MAP3K5	0.60435535
64	CDK6	0.59708858
65	KSR2	0.56287865
66	PRKG1	0.56075449
67	CSNK1D	0.55058918
68	NLK	0.53005526
69	MAP3K1	0.52979025
70	MAP2K3	0.52079746
71	BRD4	0.51104788
72	SRC	0.50525870
73	JAK1	0.48470280
74	PIK3CG	0.47283319
75	MAP3K7	0.45401452
76	RPS6KA3	0.45310937
77	NEK1	0.45117041
78	SCYL2	0.42423825
79	MATK	0.40693293
80	MTOR	0.39929562
81	CDK4	0.38997494
82	CSNK2A2	0.38978151
83	BRSK1	0.38595334
84	JAK2	0.37990147
85	PRKACA	0.36184058
86	CSNK2A1	0.36078559
87	NEK2	0.34663870
88	MAP2K6	0.33710395
89	STK39	0.33546084
90	PTK6	0.33290282
91	MAP3K6	0.30752507
92	PRKCB	0.30663014
93	PRKACB	0.29859061
94	YES1	0.29485268
95	CAMKK2	0.29428666
96	NTRK2	0.29077003
97	FER	0.28680433
98	MET	0.26938861
99	MAPK3	0.26246530
100	PDGFRB	0.25969608

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Complement and coagulation cascades_Homo sapiens_hsa04610	4.70776850
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.44979871
3	Caffeine metabolism_Homo sapiens_hsa00232	3.82354555
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.52978328
5	* Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.11387840
6	* Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.10938208
7	* Retinol metabolism_Homo sapiens_hsa00830	3.02488647
8	Fatty acid degradation_Homo sapiens_hsa00071	2.86614776
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.62320201
10	* Chemical carcinogenesis_Homo sapiens_hsa05204	2.62102722
11	Arginine biosynthesis_Homo sapiens_hsa00220	2.62018791
12	* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.58018049
13	Tyrosine metabolism_Homo sapiens_hsa00350	2.47391338
14	Phenylalanine metabolism_Homo sapiens_hsa00360	2.47078791
15	* Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.40338336
16	Histidine metabolism_Homo sapiens_hsa00340	2.26126380
17	* Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.21580463
18	* Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.10531183
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.02172381
20	Butanoate metabolism_Homo sapiens_hsa00650	1.86125977
21	Bile secretion_Homo sapiens_hsa04976	1.72015106
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.64223201
23	PPAR signaling pathway_Homo sapiens_hsa03320	1.63322616
24	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.58884629
25	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.58561598
26	* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.51494606
27	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.51224799
28	* Starch and sucrose metabolism_Homo sapiens_hsa00500	1.51048481
29	Fat digestion and absorption_Homo sapiens_hsa04975	1.41876244
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.41795082
31	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.41350182
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.36559549
33	Peroxisome_Homo sapiens_hsa04146	1.28625876
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.26282228
35	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.19930846
36	Prion diseases_Homo sapiens_hsa05020	1.19510798
37	Fatty acid metabolism_Homo sapiens_hsa01212	1.19095126
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.13318282
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.13196992
40	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.11865801
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.10046740
42	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.06653163
43	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.05424682
44	Arginine and proline metabolism_Homo sapiens_hsa00330	1.04303204
45	Pyruvate metabolism_Homo sapiens_hsa00620	1.02622197
46	Propanoate metabolism_Homo sapiens_hsa00640	1.02385106
47	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.02133398
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.98827186
49	ABC transporters_Homo sapiens_hsa02010	0.97084684
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.88467179
51	Carbon metabolism_Homo sapiens_hsa01200	0.86415450
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.84640125
53	One carbon pool by folate_Homo sapiens_hsa00670	0.84573795
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82522398
55	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.72174965
56	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.71458450
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.61264837
58	Lysine degradation_Homo sapiens_hsa00310	0.61028870
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.59331480
60	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.47559072
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42398933
62	Pertussis_Homo sapiens_hsa05133	0.42295835
63	* Metabolic pathways_Homo sapiens_hsa01100	0.41123681
64	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.40708448
65	Other glycan degradation_Homo sapiens_hsa00511	0.39149596
66	Insulin resistance_Homo sapiens_hsa04931	0.33824876
67	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.33401271
68	Fatty acid elongation_Homo sapiens_hsa00062	0.30120630
69	Glucagon signaling pathway_Homo sapiens_hsa04922	0.27524012
70	Renin-angiotensin system_Homo sapiens_hsa04614	0.25297323
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25011060
72	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.22459731
73	Sulfur relay system_Homo sapiens_hsa04122	0.20822858
74	Sulfur metabolism_Homo sapiens_hsa00920	0.18298623
75	Pentose phosphate pathway_Homo sapiens_hsa00030	0.14737107
76	Galactose metabolism_Homo sapiens_hsa00052	0.13783244
77	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.08741807
78	Glutathione metabolism_Homo sapiens_hsa00480	0.08722448
79	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.06450584
80	AMPK signaling pathway_Homo sapiens_hsa04152	0.06280713
81	Mineral absorption_Homo sapiens_hsa04978	0.05294764
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.04538744
83	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.02347178
84	Nitrogen metabolism_Homo sapiens_hsa00910	0.02218905
85	Selenocompound metabolism_Homo sapiens_hsa00450	0.00802633
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.2396930
87	Serotonergic synapse_Homo sapiens_hsa04726	-0.2053180
88	ECM-receptor interaction_Homo sapiens_hsa04512	-0.1555298
89	Circadian rhythm_Homo sapiens_hsa04710	-0.1523981
90	Folate biosynthesis_Homo sapiens_hsa00790	-0.1497959
91	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1374871
92	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	-0.1185868
93	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.1094790
94	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.1085971
95	Amoebiasis_Homo sapiens_hsa05146	-0.0636185
96	African trypanosomiasis_Homo sapiens_hsa05143	-0.0510296
97	Insulin signaling pathway_Homo sapiens_hsa04910	-0.0411908
98	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0362372
99	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.0335701
100	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.0221065

UGT2B10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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