ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cholesterol esterification (GO:0010872)	7.55844635
2	high-density lipoprotein particle remodeling (GO:0034375)	7.44054597
3	plasma lipoprotein particle assembly (GO:0034377)	7.20469706
4	phospholipid efflux (GO:0033700)	7.12326152
5	reverse cholesterol transport (GO:0043691)	6.54112628
6	very-low-density lipoprotein particle assembly (GO:0034379)	6.48499131
7	plasma lipoprotein particle remodeling (GO:0034369)	6.16590856
8	protein-lipid complex remodeling (GO:0034368)	6.16590856
9	macromolecular complex remodeling (GO:0034367)	6.16590856
10	protein-lipid complex assembly (GO:0065005)	6.15754510
11	regulation of triglyceride catabolic process (GO:0010896)	6.15334754
12	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.04884310
13	negative regulation of fibrinolysis (GO:0051918)	5.85819495
14	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	5.84478000
15	regulation of protein activation cascade (GO:2000257)	5.83854630
16	negative regulation of lipase activity (GO:0060192)	5.83535191
17	complement activation, alternative pathway (GO:0006957)	5.68042812
18	cholesterol efflux (GO:0033344)	5.63226561
19	phospholipid homeostasis (GO:0055091)	5.40117150
20	regulation of fibrinolysis (GO:0051917)	5.32735665
21	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.30488481
22	L-phenylalanine catabolic process (GO:0006559)	5.30488481
23	plasma lipoprotein particle organization (GO:0071827)	5.30310646
24	regulation of complement activation (GO:0030449)	5.22706293
25	plasma lipoprotein particle clearance (GO:0034381)	5.09272301
26	low-density lipoprotein particle remodeling (GO:0034374)	4.92112254
27	protein carboxylation (GO:0018214)	4.88900331
28	peptidyl-glutamic acid carboxylation (GO:0017187)	4.88900331
29	negative regulation of sterol transport (GO:0032372)	4.85838245
30	negative regulation of cholesterol transport (GO:0032375)	4.85838245
31	protein-lipid complex subunit organization (GO:0071825)	4.84718058
32	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.58216090
33	L-phenylalanine metabolic process (GO:0006558)	4.58216090
34	negative regulation of glycogen biosynthetic process (GO:0045719)	4.41642448
35	blood coagulation, intrinsic pathway (GO:0007597)	4.36585706
36	glyoxylate metabolic process (GO:0046487)	4.35018154
37	regulation of lipoprotein particle clearance (GO:0010984)	4.34802735
38	triglyceride homeostasis (GO:0070328)	4.29545370
39	acylglycerol homeostasis (GO:0055090)	4.29545370
40	cellular glucuronidation (GO:0052695)	4.01278738
41	bile acid biosynthetic process (GO:0006699)	3.99717629
42	aromatic amino acid family catabolic process (GO:0009074)	3.98310281
43	regulation of lipoprotein metabolic process (GO:0050746)	3.89777562
44	glucuronate metabolic process (GO:0019585)	3.89580914
45	uronic acid metabolic process (GO:0006063)	3.89580914
46	regulation of heterotypic cell-cell adhesion (GO:0034114)	3.89556391
47	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.88745207
48	positive regulation of lipid catabolic process (GO:0050996)	3.88507791
49	intestinal cholesterol absorption (GO:0030299)	3.78354579
50	negative regulation of protein activation cascade (GO:2000258)	3.78214835
51	cholesterol homeostasis (GO:0042632)	3.65990500
52	positive regulation of triglyceride lipase activity (GO:0061365)	3.62810531
53	positive regulation of lipoprotein lipase activity (GO:0051006)	3.62810531
54	heme transport (GO:0015886)	3.58922539
55	cholesterol transport (GO:0030301)	3.57919191
56	sterol transport (GO:0015918)	3.57919191
57	sterol homeostasis (GO:0055092)	3.57089566
58	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.53103775
59	fibrinolysis (GO:0042730)	3.49575792
60	negative regulation of blood coagulation (GO:0030195)	3.42103970
61	negative regulation of hemostasis (GO:1900047)	3.42103970
62	lipoprotein metabolic process (GO:0042157)	3.39514059
63	serine family amino acid catabolic process (GO:0009071)	3.35028909
64	drug catabolic process (GO:0042737)	3.33498749
65	response to dietary excess (GO:0002021)	3.33312728
66	bile acid metabolic process (GO:0008206)	3.32927693
67	protein activation cascade (GO:0072376)	3.30589095
68	regulation of humoral immune response (GO:0002920)	3.28640396
69	negative regulation of glycogen metabolic process (GO:0070874)	3.28125822
70	hormone catabolic process (GO:0042447)	3.27712559
71	flavonoid metabolic process (GO:0009812)	3.25512704
72	urea metabolic process (GO:0019627)	3.25355309
73	epoxygenase P450 pathway (GO:0019373)	3.19458176
74	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.15541039
75	cellular anion homeostasis (GO:0030002)	3.14128143
76	lipoprotein transport (GO:0042953)	3.13949917
77	acute-phase response (GO:0006953)	3.13654852
78	tyrosine metabolic process (GO:0006570)	3.12491881
79	regulation of sterol transport (GO:0032371)	3.09507488
80	regulation of cholesterol transport (GO:0032374)	3.09507488
81	negative regulation of coagulation (GO:0050819)	3.09312334
82	positive regulation of triglyceride metabolic process (GO:0090208)	3.07525389
83	drug metabolic process (GO:0017144)	3.07213482
84	regulation of plasminogen activation (GO:0010755)	3.02552243
85	lipid homeostasis (GO:0055088)	3.01672267
86	imidazole-containing compound metabolic process (GO:0052803)	3.01049446
87	positive regulation of steroid metabolic process (GO:0045940)	2.99685496
88	bile acid and bile salt transport (GO:0015721)	2.98409467
89	negative regulation of wound healing (GO:0061045)	2.98045404
90	water-soluble vitamin biosynthetic process (GO:0042364)	2.96734319
91	ethanol oxidation (GO:0006069)	2.96613114
92	xenobiotic catabolic process (GO:0042178)	2.96345957
93	positive regulation of hemostasis (GO:1900048)	2.92320797
94	positive regulation of blood coagulation (GO:0030194)	2.92320797
95	urea cycle (GO:0000050)	2.89907282
96	regulation of cytokine secretion involved in immune response (GO:0002739)	2.85679530
97	anion homeostasis (GO:0055081)	2.83856673
98	nitrogen cycle metabolic process (GO:0071941)	2.83438738
99	diacylglycerol metabolic process (GO:0046339)	2.83362002
100	indolalkylamine catabolic process (GO:0046218)	2.80818548

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	6.58605494
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.71929838
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.25325683
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	4.12201374
5	RXR_22158963_ChIP-Seq_LIVER_Mouse	4.08972280
6	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.47257175
7	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.30860345
8	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.26760143
9	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.83459378
10	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.58671753
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.42060681
12	* FOXA2_19822575_ChIP-Seq_HepG2_Human	2.23647916
13	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.11802820
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.01840621
15	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.91850797
16	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.71555886
17	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.66649444
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65676391
19	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.54312328
20	DROSHA_22980978_ChIP-Seq_HELA_Human	1.43736013
21	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.39495213
22	* FOXA1_25552417_ChIP-Seq_VCAP_Human	1.38012847
23	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.36125851
24	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28235075
25	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.27581507
26	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24514738
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24514738
28	RUNX_20019798_ChIP-Seq_JUKART_Human	1.23095149
29	GATA4_25053715_ChIP-Seq_YYC3_Human	1.21953594
30	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.20787223
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20019294
32	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.12777001
33	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.11773767
34	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11159561
35	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.07744026
36	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.03595799
37	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.00516665
38	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.99188785
39	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.99188785
40	ER_23166858_ChIP-Seq_MCF-7_Human	0.99188126
41	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.98909238
42	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.98891478
43	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.98000159
44	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.97514698
45	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96549465
46	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.96401840
47	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95117361
48	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.94984564
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94854965
50	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.91712434
51	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.89259841
52	GBX2_23144817_ChIP-Seq_PC3_Human	0.88336320
53	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.86138358
54	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.85819518
55	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85447326
56	ERA_21632823_ChIP-Seq_H3396_Human	0.85349001
57	* FOXA1_25329375_ChIP-Seq_VCAP_Human	0.85249674
58	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.85249674
59	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.84924472
60	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.84678909
61	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.84333344
62	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.84230881
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.83368064
64	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.82495662
65	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.82464464
66	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.81864781
67	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.81308868
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.80944821
69	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.80648618
70	HTT_18923047_ChIP-ChIP_STHdh_Human	0.77735657
71	REST_21632747_ChIP-Seq_MESCs_Mouse	0.77697342
72	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.77584308
73	TP53_18474530_ChIP-ChIP_U2OS_Human	0.77002001
74	TCF4_23295773_ChIP-Seq_U87_Human	0.76877131
75	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.76640700
76	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.76524665
77	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.76135563
78	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.75052483
79	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.75024521
80	NCOR_22424771_ChIP-Seq_293T_Human	0.72852494
81	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.72474682
82	STAT3_23295773_ChIP-Seq_U87_Human	0.72417028
83	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.71695595
84	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.70516824
85	SCL_19346495_ChIP-Seq_HPC-7_Human	0.70310089
86	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.70115243
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.69759082
88	SMRT_27268052_Chip-Seq_Bcells_Human	0.69614007
89	BCAT_22108803_ChIP-Seq_LS180_Human	0.69283267
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.69113657
91	SOX2_19829295_ChIP-Seq_ESCs_Human	0.69113657
92	AHR_22903824_ChIP-Seq_MCF-7_Human	0.69007880
93	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.68777953
94	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.68774823
95	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.68225737
96	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.68116617
97	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.67840332
98	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.67671479
99	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.67570335
100	AR_20517297_ChIP-Seq_VCAP_Human	0.67278142

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	5.41373284
2	MP0009840_abnormal_foam_cell	4.33241988
3	MP0005360_urolithiasis	4.28221313
4	MP0002138_abnormal_hepatobiliary_system	4.23958689
5	MP0005085_abnormal_gallbladder_physiolo	3.94492295
6	MP0010329_abnormal_lipoprotein_level	3.52492049
7	MP0005365_abnormal_bile_salt	3.32398339
8	MP0003195_calcinosis	2.72190848
9	MP0001666_abnormal_nutrient_absorption	2.71355300
10	MP0003191_abnormal_cellular_cholesterol	2.52515946
11	MP0008875_abnormal_xenobiotic_pharmacok	2.52198145
12	MP0003122_maternal_imprinting	2.45841174
13	MP0002876_abnormal_thyroid_physiology	2.39984971
14	MP0003252_abnormal_bile_duct	2.38127625
15	MP0005646_abnormal_pituitary_gland	2.26355302
16	MP0005408_hypopigmentation	2.22827411
17	MP0004019_abnormal_vitamin_homeostasis	2.08607458
18	MP0000604_amyloidosis	2.05338985
19	MP0003567_abnormal_fetal_cardiomyocyte	2.04187315
20	MP0003868_abnormal_feces_composition	1.99348402
21	MP0009379_abnormal_foot_pigmentation	1.99030380
22	MP0004142_abnormal_muscle_tone	1.95072026
23	MP0005464_abnormal_platelet_physiology	1.92806068
24	MP0009053_abnormal_anal_canal	1.91371649
25	MP0006292_abnormal_olfactory_placode	1.87694408
26	MP0003123_paternal_imprinting	1.86500377
27	MP0003890_abnormal_embryonic-extraembry	1.82469810
28	MP0005332_abnormal_amino_acid	1.81242691
29	MP0002160_abnormal_reproductive_system	1.77130697
30	MP0003879_abnormal_hair_cell	1.56758666
31	MP0005379_endocrine/exocrine_gland_phen	1.53595221
32	MP0008961_abnormal_basal_metabolism	1.52117172
33	MP0002118_abnormal_lipid_homeostasis	1.47884651
34	MP0008872_abnormal_physiological_respon	1.40489271
35	MP0005084_abnormal_gallbladder_morpholo	1.38315722
36	MP0002837_dystrophic_cardiac_calcinosis	1.33371804
37	MP0005409_darkened_coat_color	1.33343012
38	MP0005389_reproductive_system_phenotype	1.32545707
39	MP0003011_delayed_dark_adaptation	1.31944429
40	MP0005670_abnormal_white_adipose	1.30687442
41	MP0000537_abnormal_urethra_morphology	1.28702939
42	MP0003724_increased_susceptibility_to	1.23551369
43	MP0004130_abnormal_muscle_cell	1.23049298
44	MP0002089_abnormal_postnatal_growth/wei	1.22143066
45	MP0004145_abnormal_muscle_electrophysio	1.21190715
46	MP0000609_abnormal_liver_physiology	1.20358587
47	MP0003646_muscle_fatigue	1.17222402
48	MP0001348_abnormal_lacrimal_gland	1.13360029
49	MP0003638_abnormal_response/metabolism_	1.10568202
50	MP0003436_decreased_susceptibility_to	1.05374071
51	MP0005636_abnormal_mineral_homeostasis	1.05307898
52	MP0001986_abnormal_taste_sensitivity	1.02073806
53	MP0003942_abnormal_urinary_system	0.99506370
54	MP0000685_abnormal_immune_system	0.96716254
55	MP0002132_abnormal_respiratory_system	0.96670436
56	MP0004883_abnormal_blood_vessel	0.96090360
57	MP0001485_abnormal_pinna_reflex	0.94211650
58	MP0001919_abnormal_reproductive_system	0.90498323
59	MP0005164_abnormal_response_to	0.90408574
60	MP0009642_abnormal_blood_homeostasis	0.88879228
61	MP0005551_abnormal_eye_electrophysiolog	0.88576575
62	MP0003121_genomic_imprinting	0.88493242
63	MP0009765_abnormal_xenobiotic_induced	0.87321735
64	MP0008004_abnormal_stomach_pH	0.84258511
65	MP0005319_abnormal_enzyme/_coenzyme	0.80257936
66	MP0009643_abnormal_urine_homeostasis	0.78558781
67	MP0003632_abnormal_nervous_system	0.76705676
68	MP0003878_abnormal_ear_physiology	0.75674653
69	MP0005377_hearing/vestibular/ear_phenot	0.75674653
70	MP0001764_abnormal_homeostasis	0.75477158
71	MP0000639_abnormal_adrenal_gland	0.74941477
72	MP0000598_abnormal_liver_morphology	0.74258053
73	MP0003315_abnormal_perineum_morphology	0.74226787
74	MP0005220_abnormal_exocrine_pancreas	0.72732691
75	MP0005410_abnormal_fertilization	0.68401481
76	MP0003119_abnormal_digestive_system	0.66884173
77	MP0008789_abnormal_olfactory_epithelium	0.66846875
78	MP0005376_homeostasis/metabolism_phenot	0.66516869
79	MP0003172_abnormal_lysosome_physiology	0.65915494
80	MP0005448_abnormal_energy_balance	0.65630515
81	MP0009115_abnormal_fat_cell	0.65623636
82	MP0002282_abnormal_trachea_morphology	0.64386670
83	MP0002249_abnormal_larynx_morphology	0.63823521
84	MP0004133_heterotaxia	0.62127786
85	MP0001188_hyperpigmentation	0.61940554
86	MP0004264_abnormal_extraembryonic_tissu	0.61257224
87	MP0002928_abnormal_bile_duct	0.60732892
88	MP0005584_abnormal_enzyme/coenzyme_acti	0.59975346
89	MP0005195_abnormal_posterior_eye	0.59502793
90	MP0008469_abnormal_protein_level	0.59240743
91	MP0005187_abnormal_penis_morphology	0.57404748
92	MP0003953_abnormal_hormone_level	0.56258922
93	MP0002135_abnormal_kidney_morphology	0.55251302
94	MP0002557_abnormal_social/conspecific_i	0.54378029
95	MP0001765_abnormal_ion_homeostasis	0.53151081
96	MP0001661_extended_life_span	0.52304726
97	MP0001293_anophthalmia	0.51876472
98	MP0005499_abnormal_olfactory_system	0.49572766
99	MP0005394_taste/olfaction_phenotype	0.49572766
100	MP0001440_abnormal_grooming_behavior	0.48913792

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Spontaneous abortion (HP:0005268)	6.74241814
2	Deep venous thrombosis (HP:0002625)	6.66938316
3	Hypobetalipoproteinemia (HP:0003563)	6.42577019
4	Abnormality of the common coagulation pathway (HP:0010990)	5.94224803
5	Prolonged partial thromboplastin time (HP:0003645)	5.45874458
6	Hyperlipoproteinemia (HP:0010980)	5.04146418
7	Hypolipoproteinemia (HP:0010981)	4.87575904
8	Complement deficiency (HP:0004431)	4.76167211
9	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.67581928
10	Osteomalacia (HP:0002749)	4.40463986
11	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.36654622
12	Joint hemorrhage (HP:0005261)	4.34245351
13	Gingival bleeding (HP:0000225)	4.29218775
14	Xanthomatosis (HP:0000991)	4.22495979
15	Hypoalphalipoproteinemia (HP:0003233)	3.94054037
16	Glomerulonephritis (HP:0000099)	3.78732678
17	Hyperglycinemia (HP:0002154)	3.73668360
18	Intrahepatic cholestasis (HP:0001406)	3.73387101
19	Abnormality of complement system (HP:0005339)	3.53957255
20	Abnormality of the nasal septum (HP:0000419)	3.35676155
21	Epidermoid cyst (HP:0200040)	3.32027586
22	Abnormality of the proximal phalanges of the hand (HP:0009834)	3.26247684
23	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.26056812
24	Fused cervical vertebrae (HP:0002949)	3.16301824
25	Conjugated hyperbilirubinemia (HP:0002908)	2.96626816
26	Retinal atrophy (HP:0001105)	2.89422305
27	Hypercholesterolemia (HP:0003124)	2.88711399
28	Fat malabsorption (HP:0002630)	2.86334580
29	Amyloidosis (HP:0011034)	2.80151919
30	Menorrhagia (HP:0000132)	2.78274598
31	Acanthocytosis (HP:0001927)	2.77341010
32	Abnormality of pyrimidine metabolism (HP:0004353)	2.74518981
33	Abnormality of the middle phalanges of the toes (HP:0010183)	2.61717023
34	Decreased subcutaneous fat (HP:0001002)	2.58290742
35	Hypoplasia of the fovea (HP:0007750)	2.51653755
36	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.51653755
37	Bilateral microphthalmos (HP:0007633)	2.48610773
38	Systemic lupus erythematosus (HP:0002725)	2.47927770
39	Enlarged kidneys (HP:0000105)	2.46585027
40	Fatigable weakness (HP:0003473)	2.44000559
41	Abnormality of the neuromuscular junction (HP:0003398)	2.44000559
42	Hypoplasia of the uterus (HP:0000013)	2.40101223
43	Pigmentary retinal degeneration (HP:0001146)	2.37594727
44	Thrombophlebitis (HP:0004418)	2.31786889
45	Alveolar cell carcinoma (HP:0006519)	2.31714945
46	Joint swelling (HP:0001386)	2.27962382
47	Short hallux (HP:0010109)	2.26365817
48	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.23965011
49	Nephritis (HP:0000123)	2.21808626
50	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.21277351
51	Epistaxis (HP:0000421)	2.19851587
52	Neoplasm of the tracheobronchial system (HP:0100552)	2.19460522
53	Vitreoretinal degeneration (HP:0000655)	2.19024186
54	Abnormality of urine glucose concentration (HP:0011016)	2.15035407
55	Glycosuria (HP:0003076)	2.15035407
56	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.14941369
57	Abnormality of glycine metabolism (HP:0010895)	2.13484029
58	Abnormality of serine family amino acid metabolism (HP:0010894)	2.13484029
59	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.04687793
60	Recurrent gram-negative bacterial infections (HP:0005420)	2.04512445
61	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.04338746
62	Chronic hepatic failure (HP:0100626)	2.01117855
63	Genetic anticipation (HP:0003743)	2.00013014
64	Abnormality of subcutaneous fat tissue (HP:0001001)	1.99640078
65	Morphological abnormality of the middle ear (HP:0008609)	1.99266827
66	Poikilocytosis (HP:0004447)	1.97981582
67	Short 1st metacarpal (HP:0010034)	1.97753551
68	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.97753551
69	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.97538823
70	Cerebral palsy (HP:0100021)	1.94760121
71	Hyperammonemia (HP:0001987)	1.89715759
72	Abnormality of vitamin metabolism (HP:0100508)	1.89680905
73	Vascular calcification (HP:0004934)	1.86604616
74	Abnormality of serum amino acid levels (HP:0003112)	1.85984597
75	Prolonged bleeding time (HP:0003010)	1.85795815
76	Skin nodule (HP:0200036)	1.83600731
77	Abnormality of the 1st metacarpal (HP:0010009)	1.83375552
78	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.81269741
79	Abnormal biliary tract physiology (HP:0012439)	1.80987439
80	Bile duct proliferation (HP:0001408)	1.80987439
81	Pendular nystagmus (HP:0012043)	1.80569734
82	Congenital stationary night blindness (HP:0007642)	1.80488157
83	Synostosis of carpal bones (HP:0005048)	1.80081209
84	Purpura (HP:0000979)	1.79482992
85	Stenosis of the external auditory canal (HP:0000402)	1.79162671
86	Facial shape deformation (HP:0011334)	1.77401389
87	Potter facies (HP:0002009)	1.77401389
88	Stomach cancer (HP:0012126)	1.76485503
89	Aplasia/Hypoplasia of the macula (HP:0008059)	1.76161446
90	Goiter (HP:0000853)	1.75254597
91	Abnormality of the fovea (HP:0000493)	1.74225273
92	Easy fatigability (HP:0003388)	1.73629265
93	Abnormal delivery (HP:0001787)	1.73215036
94	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.73109937
95	Renal cortical cysts (HP:0000803)	1.71394038
96	Abnormality of transition element cation homeostasis (HP:0011030)	1.70415091
97	Short femoral neck (HP:0100864)	1.70088025
98	Diastasis recti (HP:0001540)	1.68434712
99	Synostosis involving the elbow (HP:0003938)	1.68020169
100	Humeroradial synostosis (HP:0003041)	1.68020169

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIK3CG	3.04870614
2	FLT3	2.90630310
3	GRK1	2.88226646
4	MAPKAPK3	2.71802462
5	PKN2	2.70835039
6	TNK2	2.50270747
7	FRK	2.47843984
8	AKT3	2.29448388
9	WNK4	2.19593928
10	PDK2	2.10211002
11	KIT	1.90724990
12	PLK2	1.86668302
13	WNK3	1.76080293
14	NTRK3	1.69368423
15	STK16	1.65657908
16	DYRK1B	1.62314118
17	TEC	1.56194437
18	FES	1.55653351
19	PIK3CA	1.47622594
20	ERBB2	1.43612055
21	BTK	1.42199769
22	WNK1	1.41967068
23	MUSK	1.38749376
24	PINK1	1.33706703
25	GRK6	1.32563400
26	PRKAA1	1.28525542
27	MAP2K2	1.26936695
28	SGK223	1.25966745
29	SGK494	1.25966745
30	FGFR3	1.25915821
31	CSK	1.20741480
32	ACVR1B	1.16323189
33	PDPK1	1.14827191
34	SGK2	1.14358202
35	PRKACG	1.12311575
36	MAP2K3	1.11077378
37	FGFR4	1.06982724
38	PDK1	1.06802364
39	LYN	1.05772187
40	MAP3K9	1.00543005
41	INSRR	0.95676721
42	MARK2	0.94239288
43	EEF2K	0.93177186
44	HCK	0.92071830
45	RPS6KB1	0.89891253
46	SGK3	0.88984999
47	ABL2	0.88750085
48	RPS6KA6	0.88313354
49	ITK	0.86809706
50	PAK3	0.86309545
51	MAP3K2	0.86247735
52	MATK	0.85755810
53	MAPK15	0.85447566
54	IKBKB	0.85024610
55	CAMK1G	0.84244608
56	RPS6KA2	0.84238099
57	PRKCG	0.83775044
58	PRKCQ	0.81823945
59	PRKAA2	0.77908466
60	RET	0.77894130
61	SGK1	0.77676213
62	TAOK3	0.76241676
63	CSF1R	0.72847763
64	EPHB1	0.69487059
65	SYK	0.67449274
66	LCK	0.67122471
67	PRKCZ	0.66750776
68	CAMK1D	0.65611049
69	RPS6KC1	0.63174185
70	RPS6KL1	0.63174185
71	MAPK11	0.63043363
72	INSR	0.62928242
73	PRKACA	0.62729962
74	FYN	0.62185362
75	FGFR2	0.62026956
76	TYK2	0.61006502
77	TXK	0.59662502
78	BMPR1B	0.56643132
79	MAP3K11	0.56405783
80	STK39	0.55976192
81	SIK2	0.55488405
82	MAP2K4	0.53794454
83	JAK2	0.50263783
84	MAP2K6	0.49626094
85	ZAP70	0.49123837
86	PRKCB	0.48359888
87	MAPK9	0.48250162
88	MAPK3	0.48247514
89	TYRO3	0.47986223
90	BMX	0.46917996
91	MAPK13	0.46285610
92	RPS6KA3	0.45124307
93	STK11	0.44130908
94	IGF1R	0.43497250
95	GRK5	0.43207600
96	PRKCA	0.42746818
97	PRKG1	0.42185007
98	CSNK1E	0.41621274
99	CDK9	0.40775384
100	MAPK8	0.40686295

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Complement and coagulation cascades_Homo sapiens_hsa04610	4.18649507
2	* Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	4.04734373
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.97261820
4	* Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.48831227
5	* Pentose and glucuronate interconversions_Homo sapiens_hsa00040	3.00644903
6	* Chemical carcinogenesis_Homo sapiens_hsa05204	2.93100613
7	* Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.86548305
8	Fat digestion and absorption_Homo sapiens_hsa04975	2.76355940
9	* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.68238304
10	* Retinol metabolism_Homo sapiens_hsa00830	2.67993220
11	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.45900013
12	Caffeine metabolism_Homo sapiens_hsa00232	2.27708360
13	* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.24710899
14	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.14797861
15	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	2.04688248
16	* Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.03701385
17	Sulfur metabolism_Homo sapiens_hsa00920	1.97833960
18	Histidine metabolism_Homo sapiens_hsa00340	1.95655401
19	* Starch and sucrose metabolism_Homo sapiens_hsa00500	1.89450076
20	Fatty acid degradation_Homo sapiens_hsa00071	1.81672148
21	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.81383978
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.71092473
23	Arginine biosynthesis_Homo sapiens_hsa00220	1.66027398
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.62004185
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.57844554
26	Peroxisome_Homo sapiens_hsa04146	1.53991377
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.48532242
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.46099255
29	Tyrosine metabolism_Homo sapiens_hsa00350	1.45771362
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.45544968
31	Bile secretion_Homo sapiens_hsa04976	1.36570632
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.35704705
33	Butanoate metabolism_Homo sapiens_hsa00650	1.35479741
34	Phenylalanine metabolism_Homo sapiens_hsa00360	1.25404832
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.18250454
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.12567425
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.12539463
38	Steroid biosynthesis_Homo sapiens_hsa00100	1.05744945
39	Glycerolipid metabolism_Homo sapiens_hsa00561	1.02712246
40	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.98887966
41	Other glycan degradation_Homo sapiens_hsa00511	0.98234310
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.97305046
43	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.94844828
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91801464
45	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.90871425
46	Renin-angiotensin system_Homo sapiens_hsa04614	0.87675262
47	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.81922444
48	Ribosome_Homo sapiens_hsa03010	0.79953636
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.79255474
50	ABC transporters_Homo sapiens_hsa02010	0.77786240
51	Fatty acid metabolism_Homo sapiens_hsa01212	0.74696335
52	Arginine and proline metabolism_Homo sapiens_hsa00330	0.74319699
53	Insulin resistance_Homo sapiens_hsa04931	0.71644206
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.70749060
55	Sulfur relay system_Homo sapiens_hsa04122	0.65166972
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64497232
57	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.59455408
58	Galactose metabolism_Homo sapiens_hsa00052	0.59035928
59	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.54941344
60	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.53306997
61	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.51596247
62	African trypanosomiasis_Homo sapiens_hsa05143	0.48659352
63	* Metabolic pathways_Homo sapiens_hsa01100	0.47887986
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46846206
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46333205
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.45717027
67	Glutathione metabolism_Homo sapiens_hsa00480	0.43185245
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40333379
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.38104835
70	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34646641
71	Prion diseases_Homo sapiens_hsa05020	0.31904280
72	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.30635263
73	Phototransduction_Homo sapiens_hsa04744	0.29850229
74	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.25831676
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.25634215
76	Propanoate metabolism_Homo sapiens_hsa00640	0.25347799
77	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.24244655
78	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.22371812
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.21198797
80	Mineral absorption_Homo sapiens_hsa04978	0.19757161
81	Glucagon signaling pathway_Homo sapiens_hsa04922	0.18184798
82	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.15811015
83	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.15691489
84	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.15132573
85	Platelet activation_Homo sapiens_hsa04611	0.12021990
86	Renin secretion_Homo sapiens_hsa04924	0.11531934
87	Oxidative phosphorylation_Homo sapiens_hsa00190	0.10224840
88	One carbon pool by folate_Homo sapiens_hsa00670	0.09837915
89	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.09003811
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.08121569
91	Lysine degradation_Homo sapiens_hsa00310	0.07379050
92	Serotonergic synapse_Homo sapiens_hsa04726	0.07047918
93	Regulation of autophagy_Homo sapiens_hsa04140	0.06021146
94	Type II diabetes mellitus_Homo sapiens_hsa04930	0.05357585
95	Sphingolipid metabolism_Homo sapiens_hsa00600	0.05250403
96	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.04758276
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.04524741
98	Insulin secretion_Homo sapiens_hsa04911	0.03837635
99	Selenocompound metabolism_Homo sapiens_hsa00450	0.03531285
100	Cardiac muscle contraction_Homo sapiens_hsa04260	0.02628862

UGT2B11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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