UGT2B11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cholesterol esterification (GO:0010872)7.55844635
2high-density lipoprotein particle remodeling (GO:0034375)7.44054597
3plasma lipoprotein particle assembly (GO:0034377)7.20469706
4phospholipid efflux (GO:0033700)7.12326152
5reverse cholesterol transport (GO:0043691)6.54112628
6very-low-density lipoprotein particle assembly (GO:0034379)6.48499131
7protein-lipid complex remodeling (GO:0034368)6.16590856
8macromolecular complex remodeling (GO:0034367)6.16590856
9plasma lipoprotein particle remodeling (GO:0034369)6.16590856
10protein-lipid complex assembly (GO:0065005)6.15754510
11regulation of triglyceride catabolic process (GO:0010896)6.15334754
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.04884310
13negative regulation of fibrinolysis (GO:0051918)5.85819495
14positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.84478000
15regulation of protein activation cascade (GO:2000257)5.83854630
16negative regulation of lipase activity (GO:0060192)5.83535191
17complement activation, alternative pathway (GO:0006957)5.68042812
18cholesterol efflux (GO:0033344)5.63226561
19phospholipid homeostasis (GO:0055091)5.40117150
20regulation of fibrinolysis (GO:0051917)5.32735665
21L-phenylalanine catabolic process (GO:0006559)5.30488481
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.30488481
23plasma lipoprotein particle organization (GO:0071827)5.30310646
24regulation of complement activation (GO:0030449)5.22706293
25plasma lipoprotein particle clearance (GO:0034381)5.09272301
26low-density lipoprotein particle remodeling (GO:0034374)4.92112254
27peptidyl-glutamic acid carboxylation (GO:0017187)4.88900331
28protein carboxylation (GO:0018214)4.88900331
29negative regulation of sterol transport (GO:0032372)4.85838245
30negative regulation of cholesterol transport (GO:0032375)4.85838245
31protein-lipid complex subunit organization (GO:0071825)4.84718058
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.58216090
33L-phenylalanine metabolic process (GO:0006558)4.58216090
34negative regulation of glycogen biosynthetic process (GO:0045719)4.41642448
35blood coagulation, intrinsic pathway (GO:0007597)4.36585706
36glyoxylate metabolic process (GO:0046487)4.35018154
37regulation of lipoprotein particle clearance (GO:0010984)4.34802735
38acylglycerol homeostasis (GO:0055090)4.29545370
39triglyceride homeostasis (GO:0070328)4.29545370
40cellular glucuronidation (GO:0052695)4.01278738
41bile acid biosynthetic process (GO:0006699)3.99717629
42aromatic amino acid family catabolic process (GO:0009074)3.98310281
43regulation of lipoprotein metabolic process (GO:0050746)3.89777562
44uronic acid metabolic process (GO:0006063)3.89580914
45glucuronate metabolic process (GO:0019585)3.89580914
46regulation of heterotypic cell-cell adhesion (GO:0034114)3.89556391
47UDP-N-acetylglucosamine metabolic process (GO:0006047)3.88745207
48positive regulation of lipid catabolic process (GO:0050996)3.88507791
49intestinal cholesterol absorption (GO:0030299)3.78354579
50negative regulation of protein activation cascade (GO:2000258)3.78214835
51cholesterol homeostasis (GO:0042632)3.65990500
52positive regulation of lipoprotein lipase activity (GO:0051006)3.62810531
53positive regulation of triglyceride lipase activity (GO:0061365)3.62810531
54heme transport (GO:0015886)3.58922539
55sterol transport (GO:0015918)3.57919191
56cholesterol transport (GO:0030301)3.57919191
57sterol homeostasis (GO:0055092)3.57089566
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.53103775
59fibrinolysis (GO:0042730)3.49575792
60negative regulation of blood coagulation (GO:0030195)3.42103970
61negative regulation of hemostasis (GO:1900047)3.42103970
62lipoprotein metabolic process (GO:0042157)3.39514059
63serine family amino acid catabolic process (GO:0009071)3.35028909
64drug catabolic process (GO:0042737)3.33498749
65response to dietary excess (GO:0002021)3.33312728
66bile acid metabolic process (GO:0008206)3.32927693
67protein activation cascade (GO:0072376)3.30589095
68regulation of humoral immune response (GO:0002920)3.28640396
69negative regulation of glycogen metabolic process (GO:0070874)3.28125822
70hormone catabolic process (GO:0042447)3.27712559
71flavonoid metabolic process (GO:0009812)3.25512704
72urea metabolic process (GO:0019627)3.25355309
73epoxygenase P450 pathway (GO:0019373)3.19458176
74positive regulation of fatty acid biosynthetic process (GO:0045723)3.15541039
75cellular anion homeostasis (GO:0030002)3.14128143
76lipoprotein transport (GO:0042953)3.13949917
77acute-phase response (GO:0006953)3.13654852
78tyrosine metabolic process (GO:0006570)3.12491881
79regulation of sterol transport (GO:0032371)3.09507488
80regulation of cholesterol transport (GO:0032374)3.09507488
81negative regulation of coagulation (GO:0050819)3.09312334
82positive regulation of triglyceride metabolic process (GO:0090208)3.07525389
83drug metabolic process (GO:0017144)3.07213482
84regulation of plasminogen activation (GO:0010755)3.02552243
85lipid homeostasis (GO:0055088)3.01672267
86imidazole-containing compound metabolic process (GO:0052803)3.01049446
87positive regulation of steroid metabolic process (GO:0045940)2.99685496
88bile acid and bile salt transport (GO:0015721)2.98409467
89negative regulation of wound healing (GO:0061045)2.98045404
90water-soluble vitamin biosynthetic process (GO:0042364)2.96734319
91ethanol oxidation (GO:0006069)2.96613114
92xenobiotic catabolic process (GO:0042178)2.96345957
93positive regulation of hemostasis (GO:1900048)2.92320797
94positive regulation of blood coagulation (GO:0030194)2.92320797
95urea cycle (GO:0000050)2.89907282
96regulation of cytokine secretion involved in immune response (GO:0002739)2.85679530
97anion homeostasis (GO:0055081)2.83856673
98nitrogen cycle metabolic process (GO:0071941)2.83438738
99diacylglycerol metabolic process (GO:0046339)2.83362002
100indolalkylamine catabolic process (GO:0046218)2.80818548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.58605494
2EZH2_22144423_ChIP-Seq_EOC_Human4.71929838
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.25325683
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.12201374
5RXR_22158963_ChIP-Seq_LIVER_Mouse4.08972280
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.47257175
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.30860345
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.26760143
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.83459378
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.58671753
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42060681
12* FOXA2_19822575_ChIP-Seq_HepG2_Human2.23647916
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.11802820
14IRF1_19129219_ChIP-ChIP_H3396_Human2.01840621
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.91850797
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71555886
17HNF4A_19822575_ChIP-Seq_HepG2_Human1.66649444
18IGF1R_20145208_ChIP-Seq_DFB_Human1.65676391
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54312328
20DROSHA_22980978_ChIP-Seq_HELA_Human1.43736013
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39495213
22* FOXA1_25552417_ChIP-Seq_VCAP_Human1.38012847
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36125851
24ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28235075
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27581507
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24514738
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24514738
28RUNX_20019798_ChIP-Seq_JUKART_Human1.23095149
29GATA4_25053715_ChIP-Seq_YYC3_Human1.21953594
30AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.20787223
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20019294
32STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.12777001
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11773767
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11159561
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.07744026
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03595799
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00516665
38EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99188785
39RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99188785
40ER_23166858_ChIP-Seq_MCF-7_Human0.99188126
41TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98909238
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98891478
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98000159
44FOXO3_23340844_ChIP-Seq_DLD1_Human0.97514698
45AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96549465
46P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96401840
47TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95117361
48EZH2_27294783_Chip-Seq_ESCs_Mouse0.94984564
49GATA3_21878914_ChIP-Seq_MCF-7_Human0.94854965
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91712434
51PIAS1_25552417_ChIP-Seq_VCAP_Human0.89259841
52GBX2_23144817_ChIP-Seq_PC3_Human0.88336320
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86138358
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85819518
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85447326
56ERA_21632823_ChIP-Seq_H3396_Human0.85349001
57* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85249674
58* FOXA1_25329375_ChIP-Seq_VCAP_Human0.85249674
59KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84924472
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84678909
61EZH2_27304074_Chip-Seq_ESCs_Mouse0.84333344
62ESR1_20079471_ChIP-ChIP_T-47D_Human0.84230881
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83368064
64JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.82495662
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82464464
66MYC_27129775_Chip-Seq_CORNEA_Mouse0.81864781
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81308868
68JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80944821
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80648618
70HTT_18923047_ChIP-ChIP_STHdh_Human0.77735657
71REST_21632747_ChIP-Seq_MESCs_Mouse0.77697342
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77584308
73TP53_18474530_ChIP-ChIP_U2OS_Human0.77002001
74TCF4_23295773_ChIP-Seq_U87_Human0.76877131
75GATA1_26923725_Chip-Seq_HPCs_Mouse0.76640700
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76524665
77RNF2_27304074_Chip-Seq_ESCs_Mouse0.76135563
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75052483
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75024521
80NCOR_22424771_ChIP-Seq_293T_Human0.72852494
81RING1B_27294783_Chip-Seq_ESCs_Mouse0.72474682
82STAT3_23295773_ChIP-Seq_U87_Human0.72417028
83TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71695595
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.70516824
85SCL_19346495_ChIP-Seq_HPC-7_Human0.70310089
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.70115243
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.69759082
88SMRT_27268052_Chip-Seq_Bcells_Human0.69614007
89BCAT_22108803_ChIP-Seq_LS180_Human0.69283267
90SOX2_19829295_ChIP-Seq_ESCs_Human0.69113657
91NANOG_19829295_ChIP-Seq_ESCs_Human0.69113657
92AHR_22903824_ChIP-Seq_MCF-7_Human0.69007880
93MTF2_20144788_ChIP-Seq_MESCs_Mouse0.68777953
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.68774823
95SMAD1_18555785_Chip-Seq_ESCs_Mouse0.68225737
96RXRA_24833708_ChIP-Seq_LIVER_Mouse0.68116617
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.67840332
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67671479
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.67570335
100AR_20517297_ChIP-Seq_VCAP_Human0.67278142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.41373284
2MP0009840_abnormal_foam_cell4.33241988
3MP0005360_urolithiasis4.28221313
4MP0002138_abnormal_hepatobiliary_system4.23958689
5MP0005085_abnormal_gallbladder_physiolo3.94492295
6MP0010329_abnormal_lipoprotein_level3.52492049
7MP0005365_abnormal_bile_salt3.32398339
8MP0003195_calcinosis2.72190848
9MP0001666_abnormal_nutrient_absorption2.71355300
10MP0003191_abnormal_cellular_cholesterol2.52515946
11MP0008875_abnormal_xenobiotic_pharmacok2.52198145
12MP0003122_maternal_imprinting2.45841174
13MP0002876_abnormal_thyroid_physiology2.39984971
14MP0003252_abnormal_bile_duct2.38127625
15MP0005646_abnormal_pituitary_gland2.26355302
16MP0005408_hypopigmentation2.22827411
17MP0004019_abnormal_vitamin_homeostasis2.08607458
18MP0000604_amyloidosis2.05338985
19MP0003567_abnormal_fetal_cardiomyocyte2.04187315
20MP0003868_abnormal_feces_composition1.99348402
21MP0009379_abnormal_foot_pigmentation1.99030380
22MP0004142_abnormal_muscle_tone1.95072026
23MP0005464_abnormal_platelet_physiology1.92806068
24MP0009053_abnormal_anal_canal1.91371649
25MP0006292_abnormal_olfactory_placode1.87694408
26MP0003123_paternal_imprinting1.86500377
27MP0003890_abnormal_embryonic-extraembry1.82469810
28MP0005332_abnormal_amino_acid1.81242691
29MP0002160_abnormal_reproductive_system1.77130697
30MP0003879_abnormal_hair_cell1.56758666
31MP0005379_endocrine/exocrine_gland_phen1.53595221
32MP0008961_abnormal_basal_metabolism1.52117172
33MP0002118_abnormal_lipid_homeostasis1.47884651
34MP0008872_abnormal_physiological_respon1.40489271
35MP0005084_abnormal_gallbladder_morpholo1.38315722
36MP0002837_dystrophic_cardiac_calcinosis1.33371804
37MP0005409_darkened_coat_color1.33343012
38MP0005389_reproductive_system_phenotype1.32545707
39MP0003011_delayed_dark_adaptation1.31944429
40MP0005670_abnormal_white_adipose1.30687442
41MP0000537_abnormal_urethra_morphology1.28702939
42MP0003724_increased_susceptibility_to1.23551369
43MP0004130_abnormal_muscle_cell1.23049298
44MP0002089_abnormal_postnatal_growth/wei1.22143066
45MP0004145_abnormal_muscle_electrophysio1.21190715
46MP0000609_abnormal_liver_physiology1.20358587
47MP0003646_muscle_fatigue1.17222402
48MP0001348_abnormal_lacrimal_gland1.13360029
49MP0003638_abnormal_response/metabolism_1.10568202
50MP0003436_decreased_susceptibility_to1.05374071
51MP0005636_abnormal_mineral_homeostasis1.05307898
52MP0001986_abnormal_taste_sensitivity1.02073806
53MP0003942_abnormal_urinary_system0.99506370
54MP0000685_abnormal_immune_system0.96716254
55MP0002132_abnormal_respiratory_system0.96670436
56MP0004883_abnormal_blood_vessel0.96090360
57MP0001485_abnormal_pinna_reflex0.94211650
58MP0001919_abnormal_reproductive_system0.90498323
59MP0005164_abnormal_response_to0.90408574
60MP0009642_abnormal_blood_homeostasis0.88879228
61MP0005551_abnormal_eye_electrophysiolog0.88576575
62MP0003121_genomic_imprinting0.88493242
63MP0009765_abnormal_xenobiotic_induced0.87321735
64MP0008004_abnormal_stomach_pH0.84258511
65MP0005319_abnormal_enzyme/_coenzyme0.80257936
66MP0009643_abnormal_urine_homeostasis0.78558781
67MP0003632_abnormal_nervous_system0.76705676
68MP0005377_hearing/vestibular/ear_phenot0.75674653
69MP0003878_abnormal_ear_physiology0.75674653
70MP0001764_abnormal_homeostasis0.75477158
71MP0000639_abnormal_adrenal_gland0.74941477
72MP0000598_abnormal_liver_morphology0.74258053
73MP0003315_abnormal_perineum_morphology0.74226787
74MP0005220_abnormal_exocrine_pancreas0.72732691
75MP0005410_abnormal_fertilization0.68401481
76MP0003119_abnormal_digestive_system0.66884173
77MP0008789_abnormal_olfactory_epithelium0.66846875
78MP0005376_homeostasis/metabolism_phenot0.66516869
79MP0003172_abnormal_lysosome_physiology0.65915494
80MP0005448_abnormal_energy_balance0.65630515
81MP0009115_abnormal_fat_cell0.65623636
82MP0002282_abnormal_trachea_morphology0.64386670
83MP0002249_abnormal_larynx_morphology0.63823521
84MP0004133_heterotaxia0.62127786
85MP0001188_hyperpigmentation0.61940554
86MP0004264_abnormal_extraembryonic_tissu0.61257224
87MP0002928_abnormal_bile_duct0.60732892
88MP0005584_abnormal_enzyme/coenzyme_acti0.59975346
89MP0005195_abnormal_posterior_eye0.59502793
90MP0008469_abnormal_protein_level0.59240743
91MP0005187_abnormal_penis_morphology0.57404748
92MP0003953_abnormal_hormone_level0.56258922
93MP0002135_abnormal_kidney_morphology0.55251302
94MP0002557_abnormal_social/conspecific_i0.54378029
95MP0001765_abnormal_ion_homeostasis0.53151081
96MP0001661_extended_life_span0.52304726
97MP0001293_anophthalmia0.51876472
98MP0005499_abnormal_olfactory_system0.49572766
99MP0005394_taste/olfaction_phenotype0.49572766
100MP0001440_abnormal_grooming_behavior0.48913792

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous abortion (HP:0005268)6.74241814
2Deep venous thrombosis (HP:0002625)6.66938316
3Hypobetalipoproteinemia (HP:0003563)6.42577019
4Abnormality of the common coagulation pathway (HP:0010990)5.94224803
5Prolonged partial thromboplastin time (HP:0003645)5.45874458
6Hyperlipoproteinemia (HP:0010980)5.04146418
7Hypolipoproteinemia (HP:0010981)4.87575904
8Complement deficiency (HP:0004431)4.76167211
9Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.67581928
10Osteomalacia (HP:0002749)4.40463986
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.36654622
12Joint hemorrhage (HP:0005261)4.34245351
13Gingival bleeding (HP:0000225)4.29218775
14Xanthomatosis (HP:0000991)4.22495979
15Hypoalphalipoproteinemia (HP:0003233)3.94054037
16Glomerulonephritis (HP:0000099)3.78732678
17Hyperglycinemia (HP:0002154)3.73668360
18Intrahepatic cholestasis (HP:0001406)3.73387101
19Abnormality of complement system (HP:0005339)3.53957255
20Abnormality of the nasal septum (HP:0000419)3.35676155
21Epidermoid cyst (HP:0200040)3.32027586
22Abnormality of the proximal phalanges of the hand (HP:0009834)3.26247684
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.26056812
24Fused cervical vertebrae (HP:0002949)3.16301824
25Conjugated hyperbilirubinemia (HP:0002908)2.96626816
26Retinal atrophy (HP:0001105)2.89422305
27Hypercholesterolemia (HP:0003124)2.88711399
28Fat malabsorption (HP:0002630)2.86334580
29Amyloidosis (HP:0011034)2.80151919
30Menorrhagia (HP:0000132)2.78274598
31Acanthocytosis (HP:0001927)2.77341010
32Abnormality of pyrimidine metabolism (HP:0004353)2.74518981
33Abnormality of the middle phalanges of the toes (HP:0010183)2.61717023
34Decreased subcutaneous fat (HP:0001002)2.58290742
35Hypoplasia of the fovea (HP:0007750)2.51653755
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.51653755
37Bilateral microphthalmos (HP:0007633)2.48610773
38Systemic lupus erythematosus (HP:0002725)2.47927770
39Enlarged kidneys (HP:0000105)2.46585027
40Abnormality of the neuromuscular junction (HP:0003398)2.44000559
41Fatigable weakness (HP:0003473)2.44000559
42Hypoplasia of the uterus (HP:0000013)2.40101223
43Pigmentary retinal degeneration (HP:0001146)2.37594727
44Thrombophlebitis (HP:0004418)2.31786889
45Alveolar cell carcinoma (HP:0006519)2.31714945
46Joint swelling (HP:0001386)2.27962382
47Short hallux (HP:0010109)2.26365817
48Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.23965011
49Nephritis (HP:0000123)2.21808626
50Abnormality of the phalanges of the 5th finger (HP:0004213)2.21277351
51Epistaxis (HP:0000421)2.19851587
52Neoplasm of the tracheobronchial system (HP:0100552)2.19460522
53Vitreoretinal degeneration (HP:0000655)2.19024186
54Glycosuria (HP:0003076)2.15035407
55Abnormality of urine glucose concentration (HP:0011016)2.15035407
56Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14941369
57Abnormality of serine family amino acid metabolism (HP:0010894)2.13484029
58Abnormality of glycine metabolism (HP:0010895)2.13484029
59Aplasia/Hypoplasia of the hallux (HP:0008362)2.04687793
60Recurrent gram-negative bacterial infections (HP:0005420)2.04512445
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.04338746
62Chronic hepatic failure (HP:0100626)2.01117855
63Genetic anticipation (HP:0003743)2.00013014
64Abnormality of subcutaneous fat tissue (HP:0001001)1.99640078
65Morphological abnormality of the middle ear (HP:0008609)1.99266827
66Poikilocytosis (HP:0004447)1.97981582
67Short 1st metacarpal (HP:0010034)1.97753551
68Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.97753551
69Symphalangism affecting the phalanges of the hand (HP:0009773)1.97538823
70Cerebral palsy (HP:0100021)1.94760121
71Hyperammonemia (HP:0001987)1.89715759
72Abnormality of vitamin metabolism (HP:0100508)1.89680905
73Vascular calcification (HP:0004934)1.86604616
74Abnormality of serum amino acid levels (HP:0003112)1.85984597
75Prolonged bleeding time (HP:0003010)1.85795815
76Skin nodule (HP:0200036)1.83600731
77Abnormality of the 1st metacarpal (HP:0010009)1.83375552
78Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81269741
79Abnormal biliary tract physiology (HP:0012439)1.80987439
80Bile duct proliferation (HP:0001408)1.80987439
81Pendular nystagmus (HP:0012043)1.80569734
82Congenital stationary night blindness (HP:0007642)1.80488157
83Synostosis of carpal bones (HP:0005048)1.80081209
84Purpura (HP:0000979)1.79482992
85Stenosis of the external auditory canal (HP:0000402)1.79162671
86Potter facies (HP:0002009)1.77401389
87Facial shape deformation (HP:0011334)1.77401389
88Stomach cancer (HP:0012126)1.76485503
89Aplasia/Hypoplasia of the macula (HP:0008059)1.76161446
90Goiter (HP:0000853)1.75254597
91Abnormality of the fovea (HP:0000493)1.74225273
92Easy fatigability (HP:0003388)1.73629265
93Abnormal delivery (HP:0001787)1.73215036
94Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.73109937
95Renal cortical cysts (HP:0000803)1.71394038
96Abnormality of transition element cation homeostasis (HP:0011030)1.70415091
97Short femoral neck (HP:0100864)1.70088025
98Diastasis recti (HP:0001540)1.68434712
99Synostosis involving the elbow (HP:0003938)1.68020169
100Humeroradial synostosis (HP:0003041)1.68020169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG3.04870614
2FLT32.90630310
3GRK12.88226646
4MAPKAPK32.71802462
5PKN22.70835039
6TNK22.50270747
7FRK2.47843984
8AKT32.29448388
9WNK42.19593928
10PDK22.10211002
11KIT1.90724990
12PLK21.86668302
13WNK31.76080293
14NTRK31.69368423
15STK161.65657908
16DYRK1B1.62314118
17TEC1.56194437
18FES1.55653351
19PIK3CA1.47622594
20ERBB21.43612055
21BTK1.42199769
22WNK11.41967068
23MUSK1.38749376
24PINK11.33706703
25GRK61.32563400
26PRKAA11.28525542
27MAP2K21.26936695
28SGK2231.25966745
29SGK4941.25966745
30FGFR31.25915821
31CSK1.20741480
32ACVR1B1.16323189
33PDPK11.14827191
34SGK21.14358202
35PRKACG1.12311575
36MAP2K31.11077378
37FGFR41.06982724
38PDK11.06802364
39LYN1.05772187
40MAP3K91.00543005
41INSRR0.95676721
42MARK20.94239288
43EEF2K0.93177186
44HCK0.92071830
45RPS6KB10.89891253
46SGK30.88984999
47ABL20.88750085
48RPS6KA60.88313354
49ITK0.86809706
50PAK30.86309545
51MAP3K20.86247735
52MATK0.85755810
53MAPK150.85447566
54IKBKB0.85024610
55CAMK1G0.84244608
56RPS6KA20.84238099
57PRKCG0.83775044
58PRKCQ0.81823945
59PRKAA20.77908466
60RET0.77894130
61SGK10.77676213
62TAOK30.76241676
63CSF1R0.72847763
64EPHB10.69487059
65SYK0.67449274
66LCK0.67122471
67PRKCZ0.66750776
68CAMK1D0.65611049
69RPS6KC10.63174185
70RPS6KL10.63174185
71MAPK110.63043363
72INSR0.62928242
73PRKACA0.62729962
74FYN0.62185362
75FGFR20.62026956
76TYK20.61006502
77TXK0.59662502
78BMPR1B0.56643132
79MAP3K110.56405783
80STK390.55976192
81SIK20.55488405
82MAP2K40.53794454
83JAK20.50263783
84MAP2K60.49626094
85ZAP700.49123837
86PRKCB0.48359888
87MAPK90.48250162
88MAPK30.48247514
89TYRO30.47986223
90BMX0.46917996
91MAPK130.46285610
92RPS6KA30.45124307
93STK110.44130908
94IGF1R0.43497250
95GRK50.43207600
96PRKCA0.42746818
97PRKG10.42185007
98CSNK1E0.41621274
99CDK90.40775384
100MAPK80.40686295

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.18649507
2* Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.04734373
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.97261820
4* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.48831227
5* Pentose and glucuronate interconversions_Homo sapiens_hsa000403.00644903
6* Chemical carcinogenesis_Homo sapiens_hsa052042.93100613
7* Steroid hormone biosynthesis_Homo sapiens_hsa001402.86548305
8Fat digestion and absorption_Homo sapiens_hsa049752.76355940
9* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.68238304
10* Retinol metabolism_Homo sapiens_hsa008302.67993220
11Vitamin digestion and absorption_Homo sapiens_hsa049772.45900013
12Caffeine metabolism_Homo sapiens_hsa002322.27708360
13* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.24710899
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.14797861
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.04688248
16* Drug metabolism - other enzymes_Homo sapiens_hsa009832.03701385
17Sulfur metabolism_Homo sapiens_hsa009201.97833960
18Histidine metabolism_Homo sapiens_hsa003401.95655401
19* Starch and sucrose metabolism_Homo sapiens_hsa005001.89450076
20Fatty acid degradation_Homo sapiens_hsa000711.81672148
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81383978
22PPAR signaling pathway_Homo sapiens_hsa033201.71092473
23Arginine biosynthesis_Homo sapiens_hsa002201.66027398
24Linoleic acid metabolism_Homo sapiens_hsa005911.62004185
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57844554
26Peroxisome_Homo sapiens_hsa041461.53991377
27Tryptophan metabolism_Homo sapiens_hsa003801.48532242
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46099255
29Tyrosine metabolism_Homo sapiens_hsa003501.45771362
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.45544968
31Bile secretion_Homo sapiens_hsa049761.36570632
32Staphylococcus aureus infection_Homo sapiens_hsa051501.35704705
33Butanoate metabolism_Homo sapiens_hsa006501.35479741
34Phenylalanine metabolism_Homo sapiens_hsa003601.25404832
35Nitrogen metabolism_Homo sapiens_hsa009101.18250454
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12567425
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12539463
38Steroid biosynthesis_Homo sapiens_hsa001001.05744945
39Glycerolipid metabolism_Homo sapiens_hsa005611.02712246
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98887966
41Other glycan degradation_Homo sapiens_hsa005110.98234310
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97305046
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94844828
44Arachidonic acid metabolism_Homo sapiens_hsa005900.91801464
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90871425
46Renin-angiotensin system_Homo sapiens_hsa046140.87675262
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.81922444
48Ribosome_Homo sapiens_hsa030100.79953636
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79255474
50ABC transporters_Homo sapiens_hsa020100.77786240
51Fatty acid metabolism_Homo sapiens_hsa012120.74696335
52Arginine and proline metabolism_Homo sapiens_hsa003300.74319699
53Insulin resistance_Homo sapiens_hsa049310.71644206
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70749060
55Sulfur relay system_Homo sapiens_hsa041220.65166972
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64497232
57Dorso-ventral axis formation_Homo sapiens_hsa043200.59455408
58Galactose metabolism_Homo sapiens_hsa000520.59035928
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54941344
60Fatty acid biosynthesis_Homo sapiens_hsa000610.53306997
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.51596247
62African trypanosomiasis_Homo sapiens_hsa051430.48659352
63* Metabolic pathways_Homo sapiens_hsa011000.47887986
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46846206
65beta-Alanine metabolism_Homo sapiens_hsa004100.46333205
66Pyruvate metabolism_Homo sapiens_hsa006200.45717027
67Glutathione metabolism_Homo sapiens_hsa004800.43185245
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.40333379
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38104835
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.34646641
71Prion diseases_Homo sapiens_hsa050200.31904280
72Thyroid hormone synthesis_Homo sapiens_hsa049180.30635263
73Phototransduction_Homo sapiens_hsa047440.29850229
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25831676
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25634215
76Propanoate metabolism_Homo sapiens_hsa006400.25347799
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24244655
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22371812
79Ether lipid metabolism_Homo sapiens_hsa005650.21198797
80Mineral absorption_Homo sapiens_hsa049780.19757161
81Glucagon signaling pathway_Homo sapiens_hsa049220.18184798
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.15811015
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15691489
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15132573
85Platelet activation_Homo sapiens_hsa046110.12021990
86Renin secretion_Homo sapiens_hsa049240.11531934
87Oxidative phosphorylation_Homo sapiens_hsa001900.10224840
88One carbon pool by folate_Homo sapiens_hsa006700.09837915
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.09003811
90Systemic lupus erythematosus_Homo sapiens_hsa053220.08121569
91Lysine degradation_Homo sapiens_hsa003100.07379050
92Serotonergic synapse_Homo sapiens_hsa047260.07047918
93Regulation of autophagy_Homo sapiens_hsa041400.06021146
94Type II diabetes mellitus_Homo sapiens_hsa049300.05357585
95Sphingolipid metabolism_Homo sapiens_hsa006000.05250403
96Hematopoietic cell lineage_Homo sapiens_hsa046400.04758276
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.04524741
98Insulin secretion_Homo sapiens_hsa049110.03837635
99Selenocompound metabolism_Homo sapiens_hsa004500.03531285
100Cardiac muscle contraction_Homo sapiens_hsa042600.02628862

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