UGT2B15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycosyltransferase that is invovled in the metabolism and elimination of toxic compounts, both endogenous and of xenobiotic origin. This gene plays a role in the regulation of estrogens and androgens. This locus is present in a cluster of similar genes and pseudogenes on chromosome 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.67942386
2drug catabolic process (GO:0042737)9.15818164
3epoxygenase P450 pathway (GO:0019373)7.90327487
4negative regulation of fibrinolysis (GO:0051918)7.85279765
5regulation of fibrinolysis (GO:0051917)7.81987298
6glyoxylate metabolic process (GO:0046487)7.79613136
7omega-hydroxylase P450 pathway (GO:0097267)7.42407863
8* cellular glucuronidation (GO:0052695)7.38242134
9L-phenylalanine catabolic process (GO:0006559)7.28368408
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.28368408
11* uronic acid metabolic process (GO:0006063)7.05623033
12* glucuronate metabolic process (GO:0019585)7.05623033
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.73849621
14L-phenylalanine metabolic process (GO:0006558)6.73849621
15complement activation, alternative pathway (GO:0006957)6.63996553
16regulation of protein activation cascade (GO:2000257)6.57114758
17urea metabolic process (GO:0019627)6.54866854
18fibrinolysis (GO:0042730)6.45462213
19ethanol oxidation (GO:0006069)6.33622789
20drug metabolic process (GO:0017144)6.15867820
21bile acid biosynthetic process (GO:0006699)6.14478416
22oxidative demethylation (GO:0070989)6.10425462
23regulation of complement activation (GO:0030449)6.09152447
24nitrogen cycle metabolic process (GO:0071941)5.91257958
25bile acid metabolic process (GO:0008206)5.76310059
26phenylpropanoid metabolic process (GO:0009698)5.70244597
27aromatic amino acid family catabolic process (GO:0009074)5.61010487
28negative regulation of cholesterol transport (GO:0032375)5.56850032
29negative regulation of sterol transport (GO:0032372)5.56850032
30bile acid and bile salt transport (GO:0015721)5.52964580
31peptidyl-glutamic acid carboxylation (GO:0017187)5.42637980
32protein carboxylation (GO:0018214)5.42637980
33blood coagulation, intrinsic pathway (GO:0007597)5.41037710
34urea cycle (GO:0000050)5.35439320
35regulation of triglyceride catabolic process (GO:0010896)5.30754894
36serine family amino acid catabolic process (GO:0009071)5.29041676
37ethanol metabolic process (GO:0006067)5.13320996
38alkaloid metabolic process (GO:0009820)5.02928486
39glycine metabolic process (GO:0006544)4.82807902
40negative regulation of blood coagulation (GO:0030195)4.79962475
41negative regulation of hemostasis (GO:1900047)4.79962475
42amino-acid betaine metabolic process (GO:0006577)4.76407912
43regulation of plasminogen activation (GO:0010755)4.63449478
44hormone catabolic process (GO:0042447)4.61151745
45polyketide metabolic process (GO:0030638)4.60868171
46doxorubicin metabolic process (GO:0044598)4.60868171
47daunorubicin metabolic process (GO:0044597)4.60868171
48S-adenosylmethionine metabolic process (GO:0046500)4.56848806
49triglyceride homeostasis (GO:0070328)4.53327198
50acylglycerol homeostasis (GO:0055090)4.53327198
51fat-soluble vitamin biosynthetic process (GO:0042362)4.43554103
52negative regulation of coagulation (GO:0050819)4.42406907
53heme transport (GO:0015886)4.42236411
54phospholipid efflux (GO:0033700)4.32416074
55negative regulation of wound healing (GO:0061045)4.31917999
56arginine metabolic process (GO:0006525)4.31584642
57flavonoid metabolic process (GO:0009812)4.30625060
58protein activation cascade (GO:0072376)4.27132302
59intestinal cholesterol absorption (GO:0030299)4.26452232
60triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.23741494
61tryptophan catabolic process (GO:0006569)4.12247891
62indole-containing compound catabolic process (GO:0042436)4.12247891
63indolalkylamine catabolic process (GO:0046218)4.12247891
64aminoglycoside antibiotic metabolic process (GO:0030647)4.11966033
65primary alcohol catabolic process (GO:0034310)4.03385489
66serine family amino acid metabolic process (GO:0009069)4.00757347
67negative regulation of protein activation cascade (GO:2000258)3.99899507
68tyrosine metabolic process (GO:0006570)3.97552327
69high-density lipoprotein particle remodeling (GO:0034375)3.92361254
70complement activation (GO:0006956)3.90460741
71negative regulation of lipase activity (GO:0060192)3.85783681
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.85032899
73complement activation, classical pathway (GO:0006958)3.84449848
74positive regulation of blood coagulation (GO:0030194)3.80202271
75positive regulation of hemostasis (GO:1900048)3.80202271
76macromolecular complex remodeling (GO:0034367)3.79520907
77plasma lipoprotein particle remodeling (GO:0034369)3.79520907
78protein-lipid complex remodeling (GO:0034368)3.79520907
79regulation of humoral immune response (GO:0002920)3.76946575
80cholesterol efflux (GO:0033344)3.76143693
81cellular ketone body metabolic process (GO:0046950)3.74412961
82acute-phase response (GO:0006953)3.74400353
83* xenobiotic metabolic process (GO:0006805)3.74280744
84drug transmembrane transport (GO:0006855)3.72266912
85aromatic amino acid family metabolic process (GO:0009072)3.71887260
86positive regulation of triglyceride lipase activity (GO:0061365)3.68468205
87positive regulation of lipoprotein lipase activity (GO:0051006)3.68468205
88regulation of cholesterol esterification (GO:0010872)3.68392235
89alpha-amino acid catabolic process (GO:1901606)3.67562511
90steroid catabolic process (GO:0006706)3.63778439
91sodium-independent organic anion transport (GO:0043252)3.53212954
92very-low-density lipoprotein particle assembly (GO:0034379)3.52028434
93positive regulation of coagulation (GO:0050820)3.51034499
94imidazole-containing compound metabolic process (GO:0052803)3.50748284
95response to mercury ion (GO:0046689)3.49577075
96reverse cholesterol transport (GO:0043691)3.46887149
97cysteine metabolic process (GO:0006534)3.45640395
98positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.40886451
99amino acid salvage (GO:0043102)3.40115698
100L-methionine biosynthetic process (GO:0071265)3.40115698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.42034629
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.35444488
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.01206269
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.09815020
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.96920652
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.11176529
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.83582063
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.50285247
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.47558137
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.29436973
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19919780
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14996856
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.12551206
14HNF4A_19822575_ChIP-Seq_HepG2_Human2.02272612
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.83367549
16HTT_18923047_ChIP-ChIP_STHdh_Human1.71534644
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.67007376
18AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.56284867
19IGF1R_20145208_ChIP-Seq_DFB_Human1.55601631
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.52590172
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50997866
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.50578049
23BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.46050518
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28379457
25GATA4_25053715_ChIP-Seq_YYC3_Human1.27809353
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.25116007
27BCAT_22108803_ChIP-Seq_LS180_Human1.21945956
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19931528
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.16653992
30IRF1_19129219_ChIP-ChIP_H3396_Human1.15979311
31* FOXA1_25552417_ChIP-Seq_VCAP_Human1.14752929
32ER_23166858_ChIP-Seq_MCF-7_Human1.14002646
33PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12994425
34AR_20517297_ChIP-Seq_VCAP_Human1.11590536
35* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11091380
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06996903
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01740530
38HNFA_21074721_ChIP-Seq_CACO-2_Human1.00735781
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.00133949
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00119205
41PHF8_20622853_ChIP-Seq_HELA_Human0.98958442
42CEBPB_22108803_ChIP-Seq_LS180_Human0.98672659
43SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98420758
44CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98158614
45FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97683645
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96460142
47PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95413886
48CBP_21632823_ChIP-Seq_H3396_Human0.93819805
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93732729
50ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91710679
51CDX2_22108803_ChIP-Seq_LS180_Human0.90410465
52SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88968836
53CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88688653
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87825237
55NFYA_21822215_ChIP-Seq_K562_Human0.87746267
56KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87546046
57FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86569648
58FOXA1_25329375_ChIP-Seq_VCAP_Human0.86569648
59GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85194461
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85159872
61CBP_20019798_ChIP-Seq_JUKART_Human0.84263213
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84263213
63CRX_20693478_ChIP-Seq_RETINA_Mouse0.83477920
64CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82255902
65GBX2_23144817_ChIP-Seq_PC3_Human0.82185665
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82031012
67GATA6_25053715_ChIP-Seq_YYC3_Human0.81592882
68GATA6_21074721_ChIP-Seq_CACO-2_Human0.81492877
69SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81480200
70SOX2_20726797_ChIP-Seq_SW620_Human0.81189654
71TRIM28_21343339_ChIP-Seq_HEK293_Human0.81162006
72P53_21459846_ChIP-Seq_SAOS-2_Human0.80995596
73VDR_22108803_ChIP-Seq_LS180_Human0.80476129
74SOX2_21211035_ChIP-Seq_LN229_Human0.79175327
75SOX2_19829295_ChIP-Seq_ESCs_Human0.79082572
76NANOG_19829295_ChIP-Seq_ESCs_Human0.79082572
77TP53_18474530_ChIP-ChIP_U2OS_Human0.78961239
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.78533080
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78351659
80CBX2_22325352_ChIP-Seq_293T-Rex_Human0.78254422
81RXRA_24833708_ChIP-Seq_LIVER_Mouse0.77912162
82NCOR_22424771_ChIP-Seq_293T_Human0.77757968
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77374983
84NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76669874
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76669874
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76342224
87TCF4_18268006_ChIP-ChIP_LS174T_Human0.75159303
88ETV1_20927104_ChIP-Seq_GIST48_Human0.75061074
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74478452
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.73954209
91OCT4_21477851_ChIP-Seq_ESCs_Mouse0.73737284
92TAF15_26573619_Chip-Seq_HEK293_Human0.73625492
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73271259
94TAF2_19829295_ChIP-Seq_ESCs_Human0.72448726
95ERG_20517297_ChIP-Seq_VCAP_Human0.72151242
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.70867764
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.70777121
98STAT3_23295773_ChIP-Seq_U87_Human0.70162301
99* TCF4_22108803_ChIP-Seq_LS180_Human0.69336748
100IRF8_22096565_ChIP-ChIP_GC-B_Human0.68296969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005085_abnormal_gallbladder_physiolo6.43790006
2MP0005360_urolithiasis6.08261420
3MP0005365_abnormal_bile_salt6.07481091
4MP0008875_abnormal_xenobiotic_pharmacok5.22019559
5MP0003195_calcinosis4.89056227
6MP0002138_abnormal_hepatobiliary_system4.36224921
7MP0003252_abnormal_bile_duct4.26042651
8MP0001666_abnormal_nutrient_absorption3.63285714
9MP0003868_abnormal_feces_composition3.61864618
10MP0010329_abnormal_lipoprotein_level2.71958904
11MP0009697_abnormal_copulation2.69771616
12MP0002876_abnormal_thyroid_physiology2.60401989
13MP0003806_abnormal_nucleotide_metabolis2.54841374
14MP0009840_abnormal_foam_cell2.41358814
15MP0005332_abnormal_amino_acid2.39219800
16MP0002139_abnormal_hepatobiliary_system10.0044036
17MP0000609_abnormal_liver_physiology1.72618614
18MP0002118_abnormal_lipid_homeostasis1.66987857
19MP0001764_abnormal_homeostasis1.65596501
20MP0004019_abnormal_vitamin_homeostasis1.55610089
21MP0005408_hypopigmentation1.33310582
22MP0005319_abnormal_enzyme/_coenzyme1.20600204
23MP0003191_abnormal_cellular_cholesterol1.12171531
24MP0009643_abnormal_urine_homeostasis1.10711878
25MP0003011_delayed_dark_adaptation1.06424420
26MP0005584_abnormal_enzyme/coenzyme_acti0.97755046
27MP0005636_abnormal_mineral_homeostasis0.93590191
28MP0000598_abnormal_liver_morphology0.89958475
29MP0009053_abnormal_anal_canal0.88339144
30MP0003186_abnormal_redox_activity0.87635271
31MP0001661_extended_life_span0.86392161
32MP0008872_abnormal_physiological_respon0.86261862
33MP0005187_abnormal_penis_morphology0.83946053
34MP0009642_abnormal_blood_homeostasis0.83862296
35MP0010368_abnormal_lymphatic_system0.77130939
36MP0008469_abnormal_protein_level0.74674226
37MP0002132_abnormal_respiratory_system0.74514875
38MP0005376_homeostasis/metabolism_phenot0.73694950
39MP0003638_abnormal_response/metabolism_0.72353836
40MP0005395_other_phenotype0.72012855
41MP0000604_amyloidosis0.71214616
42MP0003879_abnormal_hair_cell0.71155934
43MP0003656_abnormal_erythrocyte_physiolo0.71076641
44MP0005535_abnormal_body_temperature0.66372077
45MP0005670_abnormal_white_adipose0.65266934
46MP0009764_decreased_sensitivity_to0.63734475
47MP0002078_abnormal_glucose_homeostasis0.62731399
48MP0010386_abnormal_urinary_bladder0.61998385
49MP0002971_abnormal_brown_adipose0.59291455
50MP0009763_increased_sensitivity_to0.58995367
51MP0002168_other_aberrant_phenotype0.57548071
52MP0002282_abnormal_trachea_morphology0.54819574
53MP0003959_abnormal_lean_body0.53827318
54MP0006036_abnormal_mitochondrial_physio0.52972651
55MP0000566_synostosis0.52249224
56MP0005266_abnormal_metabolism0.50797798
57MP0002928_abnormal_bile_duct0.50605027
58MP0005448_abnormal_energy_balance0.49618107
59MP0003718_maternal_effect0.48754526
60MP0004043_abnormal_pH_regulation0.48612531
61MP0004142_abnormal_muscle_tone0.48323664
62MP0005451_abnormal_body_composition0.47633043
63MP0005084_abnormal_gallbladder_morpholo0.47198553
64MP0005220_abnormal_exocrine_pancreas0.44696755
65MP0001756_abnormal_urination0.43329440
66MP0005334_abnormal_fat_pad0.43128767
67MP0003953_abnormal_hormone_level0.40681620
68MP0002136_abnormal_kidney_physiology0.39705818
69MP0003690_abnormal_glial_cell0.39553946
70MP0005464_abnormal_platelet_physiology0.39172032
71MP0008874_decreased_physiological_sensi0.38919683
72MP0005647_abnormal_sex_gland0.35848971
73MP0001915_intracranial_hemorrhage0.35556234
74MP0005551_abnormal_eye_electrophysiolog0.35379940
75MP0001944_abnormal_pancreas_morphology0.32439989
76MP0002249_abnormal_larynx_morphology0.32100696
77MP0003878_abnormal_ear_physiology0.31137235
78MP0005377_hearing/vestibular/ear_phenot0.31137235
79MP0002909_abnormal_adrenal_gland0.30993401
80MP0004130_abnormal_muscle_cell0.29920789
81MP0000249_abnormal_blood_vessel0.29776017
82MP0001440_abnormal_grooming_behavior0.29387867
83MP0009785_altered_susceptibility_to0.29286694
84MP0001986_abnormal_taste_sensitivity0.28011504
85MP0005645_abnormal_hypothalamus_physiol0.27659531
86MP0001663_abnormal_digestive_system0.27544453
87MP0002090_abnormal_vision0.25481906
88MP0005164_abnormal_response_to0.24824494
89MP0003183_abnormal_peptide_metabolism0.24084704
90MP0004782_abnormal_surfactant_physiolog0.23920087
91MP0003632_abnormal_nervous_system0.23331744
92MP0005166_decreased_susceptibility_to0.22231133
93MP0001485_abnormal_pinna_reflex0.21128223
94MP0005646_abnormal_pituitary_gland0.21005077
95MP0004924_abnormal_behavior0.20548096
96MP0005386_behavior/neurological_phenoty0.20548096
97MP0005023_abnormal_wound_healing0.19888623
98MP0004883_abnormal_blood_vessel0.19631066
99MP0001845_abnormal_inflammatory_respons0.19323168
100MP0002069_abnormal_eating/drinking_beha0.18172782

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.03015959
2Prolonged partial thromboplastin time (HP:0003645)7.95507586
3Hypobetalipoproteinemia (HP:0003563)7.85784153
4Abnormality of aromatic amino acid family metabolism (HP:0004338)7.78246321
5Complement deficiency (HP:0004431)7.76071673
6Conjugated hyperbilirubinemia (HP:0002908)7.09162969
7Abnormality of complement system (HP:0005339)6.22410894
8Systemic lupus erythematosus (HP:0002725)5.51205165
9Intrahepatic cholestasis (HP:0001406)5.46975576
10Hyperlipoproteinemia (HP:0010980)5.14437679
11Joint hemorrhage (HP:0005261)5.00384878
12Glomerulonephritis (HP:0000099)4.91663464
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.73649587
14Xanthomatosis (HP:0000991)4.70648020
15Abnormality of the common coagulation pathway (HP:0010990)4.46090775
16Fat malabsorption (HP:0002630)4.43779266
17Hypolipoproteinemia (HP:0010981)4.32863098
18Abnormality of pyrimidine metabolism (HP:0004353)4.31515195
19Spontaneous abortion (HP:0005268)3.99343640
20Hyperglycinemia (HP:0002154)3.94347916
21Generalized aminoaciduria (HP:0002909)3.83880994
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.78193727
23Steatorrhea (HP:0002570)3.73683607
24Nephritis (HP:0000123)3.70571239
25Hyperammonemia (HP:0001987)3.58572357
26Rickets (HP:0002748)3.45304819
27Abnormality of glycine metabolism (HP:0010895)3.42443400
28Abnormality of serine family amino acid metabolism (HP:0010894)3.42443400
29Hyperglycinuria (HP:0003108)3.31737465
30Delayed CNS myelination (HP:0002188)3.27179498
31Recurrent gram-negative bacterial infections (HP:0005420)3.23997710
32Abnormality of the intrinsic pathway (HP:0010989)3.21172027
33Vascular calcification (HP:0004934)3.19432288
34Abnormality of serum amino acid levels (HP:0003112)3.08071946
35Abnormality of urine glucose concentration (HP:0011016)2.97804654
36Glycosuria (HP:0003076)2.97804654
37Abnormality of vitamin metabolism (HP:0100508)2.92295521
38Osteomalacia (HP:0002749)2.91547173
39Mitral stenosis (HP:0001718)2.78099424
40Cardiovascular calcification (HP:0011915)2.77730355
41Hyperphosphaturia (HP:0003109)2.76961271
42Fair hair (HP:0002286)2.75867947
43Epidermoid cyst (HP:0200040)2.74276255
44Abnormality of methionine metabolism (HP:0010901)2.71802926
45Hyperbilirubinemia (HP:0002904)2.65902501
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62555822
47Hemorrhage of the eye (HP:0011885)2.62497953
48Gingival bleeding (HP:0000225)2.61938169
49Abnormality of nucleobase metabolism (HP:0010932)2.61197740
50Reduced antithrombin III activity (HP:0001976)2.59070158
51Hypercholesterolemia (HP:0003124)2.58070389
52Metabolic acidosis (HP:0001942)2.53935432
53Hydroxyprolinuria (HP:0003080)2.49287304
54Abnormality of proline metabolism (HP:0010907)2.49287304
55Ketosis (HP:0001946)2.32418120
56Hypoalphalipoproteinemia (HP:0003233)2.26440218
57Irritability (HP:0000737)2.25413304
58Abnormal urine phosphate concentration (HP:0012599)2.24000524
59Arthropathy (HP:0003040)2.22526351
60Alkalosis (HP:0001948)2.21182194
61Bifid scrotum (HP:0000048)2.20456770
62Neonatal hypoglycemia (HP:0001998)2.19835168
63Abnormality of sulfur amino acid metabolism (HP:0004339)2.19765815
64Purpura (HP:0000979)2.15042613
65Thrombophlebitis (HP:0004418)2.13503199
66Abnormal biliary tract physiology (HP:0012439)2.11298218
67Bile duct proliferation (HP:0001408)2.11298218
68Pulmonary embolism (HP:0002204)2.09051488
69Hepatocellular carcinoma (HP:0001402)2.05958534
70Lethargy (HP:0001254)2.02963152
71Abnormality of monocarboxylic acid metabolism (HP:0010996)10.0795186
72Hypophosphatemic rickets (HP:0004912)1.99160150
73Generalized hypopigmentation of hair (HP:0011358)1.98937695
74Hypochromic microcytic anemia (HP:0004840)1.95733202
75Hypoglycemic coma (HP:0001325)1.92440392
76Cerebral edema (HP:0002181)1.89707668
77Proximal tubulopathy (HP:0000114)1.89509279
78Abnormality of fatty-acid metabolism (HP:0004359)1.87759159
79Poikilocytosis (HP:0004447)1.87052669
80Abnormality of purine metabolism (HP:0004352)1.83135573
81Elevated alkaline phosphatase (HP:0003155)1.82114226
82Joint swelling (HP:0001386)1.82042933
83Azoospermia (HP:0000027)1.77724051
84Menorrhagia (HP:0000132)1.77152469
85Pancreatitis (HP:0001733)1.76838298
86Abnormal enzyme/coenzyme activity (HP:0012379)1.76761777
87Ketoacidosis (HP:0001993)1.76516294
88Cerebral palsy (HP:0100021)1.72948840
89Abnormality of transition element cation homeostasis (HP:0011030)1.72184089
90Abnormality of iron homeostasis (HP:0011031)1.70934684
91Abnormality of alkaline phosphatase activity (HP:0004379)1.70472165
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.70429142
93Sensorimotor neuropathy (HP:0007141)1.69011484
94Abnormality of the Achilles tendon (HP:0005109)1.66957955
95Enlarged kidneys (HP:0000105)1.64979280
96Cholelithiasis (HP:0001081)1.59800217
97Abnormal gallbladder morphology (HP:0012437)1.58883623
98Facial shape deformation (HP:0011334)1.57339086
99Potter facies (HP:0002009)1.57339086
100Vomiting (HP:0002013)1.56732510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.62703607
2LMTK23.40405925
3PIK3CA3.11448631
4ACVR1B2.99969986
5PIK3CG2.68533425
6INSRR2.57322792
7GRK12.56634124
8ADRBK22.53012275
9ERN12.52872161
10CASK2.40342084
11PINK12.39230769
12MAP3K122.10327258
13NTRK32.02541692
14MST1R1.93513887
15PRKCG1.89994629
16PRKACG1.89009179
17WNK31.81565557
18PRKAA21.69007118
19CAMKK21.66871968
20FGFR41.59517480
21BMPR1B1.50756800
22BCKDK1.45489802
23EPHA31.42488600
24TYK21.39713153
25PNCK1.38801306
26MAP2K41.38340598
27EPHA41.31924577
28FER1.31522697
29MAP3K21.30125432
30PRKG21.27258827
31PRKCZ1.23141820
32DAPK21.22464025
33NLK1.19043550
34TAOK31.17554362
35WNK41.15108043
36IGF1R1.13546446
37ABL21.12554968
38PAK31.10954359
39STK38L1.10014196
40ERBB21.08531814
41MAPKAPK31.08157466
42STK391.05847397
43MAPK111.03118309
44TBK11.01664002
45RIPK11.00577359
46MYLK0.99473902
47AKT30.99187638
48OXSR10.97557683
49MAP3K30.95745610
50NEK90.95591414
51PRKACA0.93308881
52FGFR30.93292608
53MUSK0.92190457
54PRKCE0.90053538
55SIK10.88293643
56TNK20.87717668
57PRKAA10.87028946
58PRKG10.84440074
59PRKCA0.81709844
60TIE10.80200663
61MET0.79639521
62TNIK0.76132841
63STK160.73217189
64BCR0.71664019
65PTK60.66004449
66CSNK1D0.65124496
67PRKCQ0.64430794
68BRSK20.63180790
69IRAK10.62450474
70MAPK150.62146492
71FGFR20.60927710
72CAMK1D0.60927289
73PDPK10.60280421
74TLK10.59013993
75MAP2K70.58365813
76DYRK20.56959237
77SGK2230.56860345
78SGK4940.56860345
79MAPK130.55629781
80MAP2K60.54907738
81SGK20.53778818
82ERBB40.53492539
83PRKCB0.53053178
84MAP3K40.51354967
85JAK20.49309269
86STK380.49135321
87CSNK1A10.48346361
88CAMK1G0.46470643
89CSNK1E0.45961016
90MAP2K20.45743667
91MAP3K110.44091575
92MAP3K10.43638978
93SGK10.43462893
94MAP2K10.43100921
95RPS6KA30.42581509
96JAK10.41832099
97ADRBK10.41207424
98RET0.36596030
99PRKACB0.36390096
100PDK10.34961059

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.61047040
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.01225065
3* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.81729840
4* Retinol metabolism_Homo sapiens_hsa008303.42413547
5* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.41370248
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31620287
7Complement and coagulation cascades_Homo sapiens_hsa046103.19168805
8* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.00534730
9* Chemical carcinogenesis_Homo sapiens_hsa052043.00459181
10* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.91700984
11* Steroid hormone biosynthesis_Homo sapiens_hsa001402.80041477
12* Drug metabolism - other enzymes_Homo sapiens_hsa009832.69536221
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41646506
14Fatty acid degradation_Homo sapiens_hsa000712.38723314
15Butanoate metabolism_Homo sapiens_hsa006502.36534135
16Arginine biosynthesis_Homo sapiens_hsa002202.27105941
17Phenylalanine metabolism_Homo sapiens_hsa003602.16309603
18Tryptophan metabolism_Homo sapiens_hsa003802.07111669
19Tyrosine metabolism_Homo sapiens_hsa003502.01029806
20Bile secretion_Homo sapiens_hsa049761.96691315
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96188237
22Linoleic acid metabolism_Homo sapiens_hsa005911.96158407
23Histidine metabolism_Homo sapiens_hsa003401.89860459
24* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.82226772
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.66589179
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66462182
27* Starch and sucrose metabolism_Homo sapiens_hsa005001.65722389
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46177384
29Peroxisome_Homo sapiens_hsa041461.44019582
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37824052
31beta-Alanine metabolism_Homo sapiens_hsa004101.36359263
32PPAR signaling pathway_Homo sapiens_hsa033201.33055308
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18010979
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17235502
35Fat digestion and absorption_Homo sapiens_hsa049751.16906460
36Arachidonic acid metabolism_Homo sapiens_hsa005901.11502752
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.09070342
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.05524956
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05328253
40Propanoate metabolism_Homo sapiens_hsa006401.05211646
41Vitamin B6 metabolism_Homo sapiens_hsa007501.04482521
42Arginine and proline metabolism_Homo sapiens_hsa003300.99759739
43Pyruvate metabolism_Homo sapiens_hsa006200.98976852
44Fatty acid metabolism_Homo sapiens_hsa012120.95315600
45Staphylococcus aureus infection_Homo sapiens_hsa051500.95073193
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94706311
47Sulfur metabolism_Homo sapiens_hsa009200.80832000
48ABC transporters_Homo sapiens_hsa020100.79792960
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76670153
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76599116
51Biosynthesis of amino acids_Homo sapiens_hsa012300.75434368
52Carbon metabolism_Homo sapiens_hsa012000.69134289
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65910992
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64709922
55Prion diseases_Homo sapiens_hsa050200.60769455
56One carbon pool by folate_Homo sapiens_hsa006700.60243723
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53391454
58Lysine degradation_Homo sapiens_hsa003100.50637792
59Sulfur relay system_Homo sapiens_hsa041220.50143615
60* Metabolic pathways_Homo sapiens_hsa011000.46867376
61Vitamin digestion and absorption_Homo sapiens_hsa049770.46475503
62Glycerolipid metabolism_Homo sapiens_hsa005610.40744926
63Fatty acid elongation_Homo sapiens_hsa000620.33528576
64Selenocompound metabolism_Homo sapiens_hsa004500.30173101
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24130896
66Steroid biosynthesis_Homo sapiens_hsa001000.22016969
67Glutathione metabolism_Homo sapiens_hsa004800.19347934
68Fructose and mannose metabolism_Homo sapiens_hsa000510.18967983
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17586443
70Mineral absorption_Homo sapiens_hsa049780.17170848
71Renin-angiotensin system_Homo sapiens_hsa046140.14981028
72Pertussis_Homo sapiens_hsa051330.12999743
73Nitrogen metabolism_Homo sapiens_hsa009100.11918088
74Fatty acid biosynthesis_Homo sapiens_hsa000610.10533038
75Insulin resistance_Homo sapiens_hsa049310.10369961
76Serotonergic synapse_Homo sapiens_hsa047260.10223679
77Ether lipid metabolism_Homo sapiens_hsa005650.08267459
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.07101358
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.05020402
80Folate biosynthesis_Homo sapiens_hsa007900.04369493
81Galactose metabolism_Homo sapiens_hsa000520.00962265
82Glucagon signaling pathway_Homo sapiens_hsa049220.00175729
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2132159
84Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2037554
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1767155
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1686777
87African trypanosomiasis_Homo sapiens_hsa05143-0.1679214
88Type II diabetes mellitus_Homo sapiens_hsa04930-0.1663584
89Protein digestion and absorption_Homo sapiens_hsa04974-0.1517570
90Other glycan degradation_Homo sapiens_hsa00511-0.1419943
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.1419287
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1396494
93AMPK signaling pathway_Homo sapiens_hsa04152-0.1174512
94Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1050973
95Pancreatic secretion_Homo sapiens_hsa04972-0.1027800
96Sphingolipid metabolism_Homo sapiens_hsa00600-0.0676163
97Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0293337
98Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0184774
99Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0115989
100Pentose phosphate pathway_Homo sapiens_hsa00030-0.0114026

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