ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of fibrinolysis (GO:0051917)	8.85204600
2	negative regulation of fibrinolysis (GO:0051918)	8.68904607
3	regulation of protein activation cascade (GO:2000257)	8.11848938
4	epoxygenase P450 pathway (GO:0019373)	7.81254592
5	regulation of complement activation (GO:0030449)	7.77479548
6	complement activation, alternative pathway (GO:0006957)	7.53249717
7	ethanol oxidation (GO:0006069)	7.46503727
8	L-phenylalanine catabolic process (GO:0006559)	7.46037801
9	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.46037801
10	omega-hydroxylase P450 pathway (GO:0097267)	7.33368374
11	exogenous drug catabolic process (GO:0042738)	7.11370302
12	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.88160977
13	L-phenylalanine metabolic process (GO:0006558)	6.88160977
14	protein carboxylation (GO:0018214)	6.83121310
15	peptidyl-glutamic acid carboxylation (GO:0017187)	6.83121310
16	drug catabolic process (GO:0042737)	6.68366068
17	blood coagulation, intrinsic pathway (GO:0007597)	6.63313857
18	glyoxylate metabolic process (GO:0046487)	6.45910322
19	fibrinolysis (GO:0042730)	6.14752418
20	ethanol metabolic process (GO:0006067)	6.09129892
21	cellular glucuronidation (GO:0052695)	5.77988212
22	imidazole-containing compound metabolic process (GO:0052803)	5.70416277
23	intestinal cholesterol absorption (GO:0030299)	5.57931152
24	regulation of plasminogen activation (GO:0010755)	5.47201255
25	uronic acid metabolic process (GO:0006063)	5.45323366
26	glucuronate metabolic process (GO:0019585)	5.45323366
27	urea metabolic process (GO:0019627)	5.45234350
28	aromatic amino acid family catabolic process (GO:0009074)	5.42246627
29	negative regulation of protein activation cascade (GO:2000258)	5.41211252
30	negative regulation of sterol transport (GO:0032372)	5.24557287
31	negative regulation of cholesterol transport (GO:0032375)	5.24557287
32	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.18123485
33	drug metabolic process (GO:0017144)	5.10738441
34	protein activation cascade (GO:0072376)	5.08997628
35	very-low-density lipoprotein particle assembly (GO:0034379)	4.98807653
36	cholesterol efflux (GO:0033344)	4.97009253
37	nitrogen cycle metabolic process (GO:0071941)	4.90785645
38	bile acid biosynthetic process (GO:0006699)	4.85550702
39	protein-lipid complex remodeling (GO:0034368)	4.83466499
40	macromolecular complex remodeling (GO:0034367)	4.83466499
41	plasma lipoprotein particle remodeling (GO:0034369)	4.83466499
42	negative regulation of hemostasis (GO:1900047)	4.83165684
43	negative regulation of blood coagulation (GO:0030195)	4.83165684
44	regulation of apoptotic cell clearance (GO:2000425)	4.77731240
45	bile acid metabolic process (GO:0008206)	4.73452447
46	regulation of humoral immune response (GO:0002920)	4.73108232
47	glutamate metabolic process (GO:0006536)	4.71566072
48	complement activation, classical pathway (GO:0006958)	4.65271117
49	oxidative demethylation (GO:0070989)	4.64742954
50	urea cycle (GO:0000050)	4.64009871
51	serine family amino acid catabolic process (GO:0009071)	4.61723218
52	high-density lipoprotein particle remodeling (GO:0034375)	4.56424240
53	negative regulation of complement activation (GO:0045916)	4.55484502
54	complement activation (GO:0006956)	4.49519865
55	regulation of cholesterol esterification (GO:0010872)	4.46037610
56	plasma lipoprotein particle assembly (GO:0034377)	4.43264242
57	negative regulation of coagulation (GO:0050819)	4.41174050
58	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.40152279
59	glycine metabolic process (GO:0006544)	4.37565632
60	positive regulation of blood coagulation (GO:0030194)	4.33320826
61	positive regulation of hemostasis (GO:1900048)	4.33320826
62	negative regulation of wound healing (GO:0061045)	4.30525966
63	low-density lipoprotein particle remodeling (GO:0034374)	4.28988773
64	bile acid and bile salt transport (GO:0015721)	4.26070654
65	reverse cholesterol transport (GO:0043691)	4.24919199
66	acylglycerol homeostasis (GO:0055090)	4.24649104
67	triglyceride homeostasis (GO:0070328)	4.24649104
68	acute-phase response (GO:0006953)	4.17141278
69	tyrosine metabolic process (GO:0006570)	4.16450671
70	phenylpropanoid metabolic process (GO:0009698)	4.11178297
71	plasma lipoprotein particle organization (GO:0071827)	4.07608229
72	positive regulation of coagulation (GO:0050820)	3.98188352
73	phospholipid efflux (GO:0033700)	3.98121754
74	regulation of triglyceride catabolic process (GO:0010896)	3.97255260
75	protein-lipid complex assembly (GO:0065005)	3.93701565
76	positive regulation of lipoprotein lipase activity (GO:0051006)	3.93435950
77	positive regulation of triglyceride lipase activity (GO:0061365)	3.93435950
78	cytolysis (GO:0019835)	3.86890739
79	plasma lipoprotein particle clearance (GO:0034381)	3.85659438
80	protein-lipid complex subunit organization (GO:0071825)	3.82735011
81	alpha-amino acid catabolic process (GO:1901606)	3.80191103
82	sodium-independent organic anion transport (GO:0043252)	3.79110378
83	amino-acid betaine metabolic process (GO:0006577)	3.74749074
84	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.73359646
85	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.73359646
86	regulation of bile acid biosynthetic process (GO:0070857)	3.69783336
87	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.63840456
88	indole-containing compound catabolic process (GO:0042436)	3.61098917
89	indolalkylamine catabolic process (GO:0046218)	3.61098917
90	tryptophan catabolic process (GO:0006569)	3.61098917
91	flavonoid metabolic process (GO:0009812)	3.60530191
92	aromatic amino acid family metabolic process (GO:0009072)	3.55465105
93	negative regulation of humoral immune response (GO:0002921)	3.55220687
94	negative regulation of lipase activity (GO:0060192)	3.53499574
95	serine family amino acid metabolic process (GO:0009069)	3.52584854
96	drug transmembrane transport (GO:0006855)	3.52198301
97	intestinal absorption (GO:0050892)	3.49582193
98	arginine metabolic process (GO:0006525)	3.49114078
99	lipoprotein metabolic process (GO:0042157)	3.44793855
100	opsonization (GO:0008228)	3.43097790

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	6.87791979
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.23054137
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.78872782
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.73480462
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.77440448
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.43056558
7	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.90352411
8	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.65803324
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.52950888
10	FOXA2_19822575_ChIP-Seq_HepG2_Human	3.39842354
11	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.90086577
12	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.65505864
13	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.26582497
14	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.21185014
15	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.2971889
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.80136790
17	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.72402096
18	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.49198957
19	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.47440042
20	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.44581728
21	GATA4_25053715_ChIP-Seq_YYC3_Human	1.43060523
22	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.39077447
23	CLOCK_20551151_ChIP-Seq_293T_Human	1.28781288
24	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.28760332
25	HTT_18923047_ChIP-ChIP_STHdh_Human	1.26990104
26	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.25501298
27	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.24198831
28	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.23926067
29	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.20254248
30	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.18558383
31	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.16852389
32	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.14052782
33	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.12620624
34	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.07918603
35	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.06572682
36	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.06232025
37	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.02582603
38	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.02093473
39	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.01120466
40	GATA6_25053715_ChIP-Seq_YYC3_Human	1.00826717
41	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.99118474
42	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.97373736
43	ZNF263_19887448_ChIP-Seq_K562_Human	0.93290220
44	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.92531441
45	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.91211321
46	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.90694576
47	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.90459297
48	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.88601219
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88358026
50	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.87756158
51	AR_21909140_ChIP-Seq_LNCAP_Human	0.87266977
52	BCAT_22108803_ChIP-Seq_LS180_Human	0.85437952
53	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.85011924
54	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.84388374
55	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.83245357
56	CEBPB_22108803_ChIP-Seq_LS180_Human	0.80692329
57	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.78119201
58	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.74374474
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.72822361
60	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.72364438
61	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.72351038
62	SOX2_20726797_ChIP-Seq_SW620_Human	0.71752382
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.71070080
64	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.70248529
65	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.70081372
66	TP53_18474530_ChIP-ChIP_U2OS_Human	0.68794386
67	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.68725473
68	CDX2_22108803_ChIP-Seq_LS180_Human	0.67872918
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.67847676
70	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.66116025
71	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.65500175
72	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.65451043
73	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.63613877
74	AR_20517297_ChIP-Seq_VCAP_Human	0.62606497
75	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.62284472
76	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.61655058
77	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.60577516
78	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.58371926
79	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.57988500
80	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.57247040
81	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.56517058
82	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.56343265
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.56289964
84	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.55852490
85	SOX2_21211035_ChIP-Seq_LN229_Human	0.55463177
86	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.55336648
87	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.54796385
88	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.54789239
89	RAC3_21632823_ChIP-Seq_H3396_Human	0.53901424
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.53869881
91	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.52725570
92	MYC_19915707_ChIP-ChIP_AK7_Human	0.52696482
93	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.52651894
94	PU1_27457419_Chip-Seq_LIVER_Mouse	0.52422406
95	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.52305227
96	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.51345388
97	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.50405558
98	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.50345404
99	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.49821465
100	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.49821465

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	9.03010376
2	MP0005360_urolithiasis	6.55996759
3	MP0005085_abnormal_gallbladder_physiolo	5.93240642
4	MP0008875_abnormal_xenobiotic_pharmacok	5.70931564
5	MP0003195_calcinosis	5.57306405
6	MP0005365_abnormal_bile_salt	5.54817980
7	MP0003252_abnormal_bile_duct	4.17278965
8	MP0001666_abnormal_nutrient_absorption	3.77217615
9	MP0010329_abnormal_lipoprotein_level	3.37440636
10	MP0003868_abnormal_feces_composition	3.29535246
11	MP0002138_abnormal_hepatobiliary_system	3.08385792
12	MP0009697_abnormal_copulation	2.47358325
13	MP0005332_abnormal_amino_acid	2.19520874
14	MP0003806_abnormal_nucleotide_metabolis	2.03102819
15	MP0000609_abnormal_liver_physiology	1.93691591
16	MP0003122_maternal_imprinting	1.90961886
17	MP0002876_abnormal_thyroid_physiology	1.85375366
18	MP0010368_abnormal_lymphatic_system	1.84415953
19	MP0005408_hypopigmentation	1.81720003
20	MP0002118_abnormal_lipid_homeostasis	1.75973538
21	MP0002132_abnormal_respiratory_system	1.70770402
22	MP0009840_abnormal_foam_cell	1.61880336
23	MP0001661_extended_life_span	1.58287216
24	MP0003191_abnormal_cellular_cholesterol	1.47180832
25	MP0001764_abnormal_homeostasis	1.43611381
26	MP0003656_abnormal_erythrocyte_physiolo	1.33035648
27	MP0004019_abnormal_vitamin_homeostasis	1.25534484
28	MP0001915_intracranial_hemorrhage	1.23948865
29	MP0000598_abnormal_liver_morphology	1.14081400
30	MP0000566_synostosis	1.07130921
31	MP0005451_abnormal_body_composition	1.05226885
32	MP0005319_abnormal_enzyme/_coenzyme	1.04229975
33	MP0009643_abnormal_urine_homeostasis	0.95910468
34	MP0002089_abnormal_postnatal_growth/wei	0.94587983
35	MP0005584_abnormal_enzyme/coenzyme_acti	0.92396200
36	MP0009642_abnormal_blood_homeostasis	0.87429532
37	MP0002282_abnormal_trachea_morphology	0.86410680
38	MP0005058_abnormal_lysosome_morphology	0.84903000
39	MP0005636_abnormal_mineral_homeostasis	0.83959764
40	MP0005670_abnormal_white_adipose	0.81194164
41	MP0005464_abnormal_platelet_physiology	0.77760012
42	MP0000604_amyloidosis	0.77143664
43	MP0003172_abnormal_lysosome_physiology	0.77004679
44	MP0003011_delayed_dark_adaptation	0.76048997
45	MP0003123_paternal_imprinting	0.74067253
46	MP0009763_increased_sensitivity_to	0.73373360
47	MP0008469_abnormal_protein_level	0.71336612
48	MP0005395_other_phenotype	0.70792314
49	MP0005376_homeostasis/metabolism_phenot	0.70627861
50	MP0002971_abnormal_brown_adipose	0.69623325
51	MP0008872_abnormal_physiological_respon	0.68661045
52	MP0003879_abnormal_hair_cell	0.63554844
53	MP0002168_other_aberrant_phenotype	0.61396078
54	MP0002078_abnormal_glucose_homeostasis	0.61007816
55	MP0000639_abnormal_adrenal_gland	0.59977072
56	MP0005084_abnormal_gallbladder_morpholo	0.57966025
57	MP0004272_abnormal_basement_membrane	0.50553679
58	MP0004782_abnormal_surfactant_physiolog	0.49227058
59	MP0005647_abnormal_sex_gland	0.47781613
60	MP0005448_abnormal_energy_balance	0.47423078
61	MP0003690_abnormal_glial_cell	0.47308339
62	MP0009053_abnormal_anal_canal	0.46518881
63	MP0003186_abnormal_redox_activity	0.46049225
64	MP0005187_abnormal_penis_morphology	0.45749276
65	MP0003183_abnormal_peptide_metabolism	0.45728652
66	MP0005535_abnormal_body_temperature	0.44459806
67	MP0004883_abnormal_blood_vessel	0.43598231
68	MP0005164_abnormal_response_to	0.43358726
69	MP0003638_abnormal_response/metabolism_	0.43111299
70	MP0001756_abnormal_urination	0.42837406
71	MP0005167_abnormal_blood-brain_barrier	0.42407994
72	MP0005023_abnormal_wound_healing	0.41493027
73	MP0003718_maternal_effect	0.40811653
74	MP0003953_abnormal_hormone_level	0.40638443
75	MP0005377_hearing/vestibular/ear_phenot	0.40420862
76	MP0003878_abnormal_ear_physiology	0.40420862
77	MP0004264_abnormal_extraembryonic_tissu	0.39978393
78	MP0002249_abnormal_larynx_morphology	0.39123963
79	MP0005220_abnormal_exocrine_pancreas	0.38984199
80	MP0005334_abnormal_fat_pad	0.38477393
81	MP0006054_spinal_hemorrhage	0.38322008
82	MP0009115_abnormal_fat_cell	0.37675285
83	MP0003567_abnormal_fetal_cardiomyocyte	0.36710468
84	MP0009780_abnormal_chondrocyte_physiolo	0.36040078
85	MP0000249_abnormal_blood_vessel	0.35919011
86	MP0005409_darkened_coat_color	0.35905884
87	MP0004130_abnormal_muscle_cell	0.35638803
88	MP0009785_altered_susceptibility_to	0.33612509
89	MP0002933_joint_inflammation	0.32658832
90	MP0002166_altered_tumor_susceptibility	0.32247900
91	MP0003941_abnormal_skin_development	0.31818874
92	MP0005266_abnormal_metabolism	0.31623260
93	MP0003632_abnormal_nervous_system	0.31420680
94	MP0002136_abnormal_kidney_physiology	0.30585792
95	MP0003115_abnormal_respiratory_system	0.29414460
96	MP0000920_abnormal_myelination	0.28706386
97	MP0009764_decreased_sensitivity_to	0.26833768
98	MP0001324_abnormal_eye_pigmentation	0.26772767
99	MP0003699_abnormal_female_reproductive	0.26193581
100	MP0000371_diluted_coat_color	0.25887200

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	9.77776412
2	Complement deficiency (HP:0004431)	8.92083641
3	Abnormality of monocarboxylic acid metabolism (HP:0010996)	8.30045277
4	Hypobetalipoproteinemia (HP:0003563)	7.32563415
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.26760450
6	Abnormality of complement system (HP:0005339)	6.97673760
7	Conjugated hyperbilirubinemia (HP:0002908)	6.72766828
8	Joint hemorrhage (HP:0005261)	6.53845537
9	Glomerulonephritis (HP:0000099)	5.76569938
10	Abnormality of the common coagulation pathway (HP:0010990)	5.76213483
11	Systemic lupus erythematosus (HP:0002725)	5.58253520
12	Intrahepatic cholestasis (HP:0001406)	4.86178759
13	Xanthomatosis (HP:0000991)	4.81011784
14	Spontaneous abortion (HP:0005268)	4.46084168
15	Hypolipoproteinemia (HP:0010981)	4.44115473
16	Hyperlipoproteinemia (HP:0010980)	4.31562723
17	Hypercholesterolemia (HP:0003124)	3.98113766
18	Recurrent gram-negative bacterial infections (HP:0005420)	3.96064973
19	Abnormality of the intrinsic pathway (HP:0010989)	3.79187673
20	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.76888757
21	Nephritis (HP:0000123)	3.68218938
22	Vascular calcification (HP:0004934)	3.41544207
23	Epidermoid cyst (HP:0200040)	3.29844073
24	Fat malabsorption (HP:0002630)	3.26976656
25	Menorrhagia (HP:0000132)	3.22773591
26	Hemorrhage of the eye (HP:0011885)	3.20393373
27	Mitral stenosis (HP:0001718)	3.11958975
28	Abnormality of pyrimidine metabolism (HP:0004353)	3.09099668
29	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.07681334
30	Gingival bleeding (HP:0000225)	3.05913616
31	Cardiovascular calcification (HP:0011915)	2.99695204
32	Hyperglycinemia (HP:0002154)	2.91799839
33	Hypoalphalipoproteinemia (HP:0003233)	2.87042070
34	Osteomalacia (HP:0002749)	2.84957183
35	Fair hair (HP:0002286)	2.81675414
36	Purpura (HP:0000979)	2.80857351
37	Rickets (HP:0002748)	2.76410000
38	Hypophosphatemic rickets (HP:0004912)	2.70365720
39	Thrombophlebitis (HP:0004418)	2.66307077
40	Arthropathy (HP:0003040)	2.62307470
41	Hyperammonemia (HP:0001987)	2.55786312
42	Abnormality of glycine metabolism (HP:0010895)	2.53318073
43	Abnormality of serine family amino acid metabolism (HP:0010894)	2.53318073
44	Hepatocellular carcinoma (HP:0001402)	2.52622924
45	Delayed CNS myelination (HP:0002188)	2.51775574
46	Generalized aminoaciduria (HP:0002909)	2.50960226
47	Abnormality of methionine metabolism (HP:0010901)	2.46953070
48	Myocardial infarction (HP:0001658)	2.36199343
49	Acanthocytosis (HP:0001927)	2.33159790
50	Hyperbilirubinemia (HP:0002904)	2.28211065
51	Pulmonary embolism (HP:0002204)	2.16579462
52	Hyperglycinuria (HP:0003108)	2.15123458
53	Skin nodule (HP:0200036)	2.07195644
54	Poikilocytosis (HP:0004447)	2.06524448
55	Abnormality of serum amino acid levels (HP:0003112)	2.05666767
56	Steatorrhea (HP:0002570)	2.00264505
57	Deep venous thrombosis (HP:0002625)	11.3843613
58	Abnormal gallbladder physiology (HP:0012438)	1.99620322
59	Cholecystitis (HP:0001082)	1.99620322
60	Abnormal tarsal ossification (HP:0008369)	1.98733055
61	Increased serum pyruvate (HP:0003542)	1.96885796
62	Bifid scrotum (HP:0000048)	1.92942760
63	Abnormality of the Achilles tendon (HP:0005109)	1.91820501
64	Reduced antithrombin III activity (HP:0001976)	1.90177012
65	Abnormality of nucleobase metabolism (HP:0010932)	1.87069597
66	Enlarged kidneys (HP:0000105)	1.86777429
67	Generalized hypopigmentation of hair (HP:0011358)	1.86032466
68	Hyperphosphaturia (HP:0003109)	1.85785936
69	Abnormality of carpal bone ossification (HP:0006257)	1.83909736
70	Blue irides (HP:0000635)	1.82917652
71	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.82114177
72	Joint swelling (HP:0001386)	1.77176521
73	Ketosis (HP:0001946)	1.77086566
74	Cholelithiasis (HP:0001081)	1.77024593
75	Potter facies (HP:0002009)	1.73479284
76	Facial shape deformation (HP:0011334)	1.73479284
77	Abnormality of glycolysis (HP:0004366)	1.73184987
78	Epistaxis (HP:0000421)	1.73119485
79	Esophageal varix (HP:0002040)	1.72912136
80	Abnormality of proline metabolism (HP:0010907)	1.72663758
81	Hydroxyprolinuria (HP:0003080)	1.72663758
82	Neonatal hypoglycemia (HP:0001998)	1.72163242
83	Hypoglycemic coma (HP:0001325)	1.67838141
84	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.67755980
85	Abnormal gallbladder morphology (HP:0012437)	1.67191013
86	Hypochromic anemia (HP:0001931)	1.66722820
87	Abnormality of urine glucose concentration (HP:0011016)	1.63033608
88	Glycosuria (HP:0003076)	1.63033608
89	Elevated alkaline phosphatase (HP:0003155)	1.62136897
90	Broad alveolar ridges (HP:0000187)	1.62085376
91	Pancreatic islet-cell hyperplasia (HP:0004510)	1.60971919
92	Abnormal delivery (HP:0001787)	1.59598926
93	Abnormal urine phosphate concentration (HP:0012599)	1.58985494
94	Increased mean platelet volume (HP:0011877)	1.57804628
95	Abnormality of the nasal septum (HP:0000419)	1.56730062
96	Increased serum ferritin (HP:0003281)	1.56567868
97	Abnormality of vitamin metabolism (HP:0100508)	1.55475396
98	Metabolic acidosis (HP:0001942)	1.53195744
99	Gangrene (HP:0100758)	1.52454392
100	Peritonitis (HP:0002586)	1.52274315

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FGFR4	6.95472389
2	FGFR3	4.79366713
3	BRSK2	3.22466008
4	CDK12	3.22411939
5	ICK	3.15291183
6	PIK3CA	2.84776913
7	WNK4	2.63095385
8	ERN1	2.55211362
9	PRKAA2	2.11399793
10	FGFR2	2.05506696
11	STK38L	2.05467363
12	EPHA2	2.03552233
13	RIPK1	1.98977076
14	AKT3	1.97551423
15	SIK1	1.95348364
16	FGFR1	1.93082375
17	TYRO3	1.77995127
18	TRIB3	1.56742193
19	MAPK11	1.55951042
20	PDGFRA	1.50399545
21	LATS1	1.48671250
22	BRSK1	1.48445118
23	TYK2	1.32033584
24	SIK2	1.30208100
25	PRKACG	1.26570806
26	CAMK1D	1.26506448
27	DYRK1B	1.21668374
28	TGFBR2	1.18687817
29	MAP3K2	1.18162780
30	EIF2AK1	1.17536585
31	WNK1	1.15642621
32	RET	1.13924256
33	PRKAA1	1.10718766
34	NEK9	1.08934981
35	ERBB2	1.07689406
36	DDR2	1.01220484
37	PDPK1	1.00496375
38	MAP3K7	1.00315513
39	STK24	1.00121340
40	MST1R	0.99202297
41	IGF1R	0.99000949
42	SGK494	0.93031019
43	SGK223	0.93031019
44	NTRK3	0.91516420
45	PKN2	0.85581295
46	BCR	0.84961026
47	CSNK1E	0.83279447
48	LATS2	0.82810862
49	SGK2	0.81234993
50	STK39	0.79553761
51	SGK3	0.76915048
52	PRKCG	0.73635327
53	CDK7	0.72644522
54	MAP3K3	0.72530921
55	EPHA4	0.71945946
56	RPS6KB1	0.71846971
57	PDK1	0.71730726
58	SGK1	0.70173693
59	MAPKAPK3	0.68994412
60	CAMK1G	0.67693154
61	CSF1R	0.67492243
62	WEE1	0.62962439
63	MAP2K4	0.62918695
64	PRKCZ	0.60977457
65	BCKDK	0.59058939
66	MAP3K5	0.58114086
67	CSNK1D	0.54449658
68	MST4	0.53558475
69	PRKG1	0.50876059
70	CDK6	0.48247649
71	FGR	0.47867718
72	PIK3CG	0.47209544
73	MTOR	0.46970718
74	CAMKK2	0.46087498
75	FER	0.44909551
76	EPHA3	0.44848755
77	BRD4	0.44637536
78	JAK1	0.44624870
79	NLK	0.44280943
80	CSNK2A1	0.42518740
81	CSNK2A2	0.42464304
82	SRC	0.39755788
83	PRKACA	0.39530889
84	CDC42BPA	0.38780598
85	RPS6KA3	0.37541977
86	MAP2K3	0.36693832
87	MAP3K12	0.36509311
88	ERBB4	0.35753396
89	MATK	0.35645527
90	IRAK3	0.34788536
91	YES1	0.34283485
92	FRK	0.34210472
93	MET	0.33218879
94	JAK2	0.32033537
95	STK38	0.30458634
96	CDK9	0.29263648
97	PRKCB	0.28346408
98	PRKACB	0.27271670
99	SMG1	0.24099574
100	EEF2K	0.23996874

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Complement and coagulation cascades_Homo sapiens_hsa04610	4.41077991
2	Caffeine metabolism_Homo sapiens_hsa00232	3.89388675
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.88073293
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.81763553
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.39838099
6	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.38847837
7	Retinol metabolism_Homo sapiens_hsa00830	3.35474486
8	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.94963329
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.85893467
10	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.83702422
11	Fatty acid degradation_Homo sapiens_hsa00071	2.78297422
12	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.53816289
13	Arginine biosynthesis_Homo sapiens_hsa00220	2.49653811
14	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.46333659
15	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.43935487
16	Tyrosine metabolism_Homo sapiens_hsa00350	2.38095232
17	Histidine metabolism_Homo sapiens_hsa00340	2.31557190
18	Phenylalanine metabolism_Homo sapiens_hsa00360	2.22543707
19	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.98987131
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.91412189
21	Butanoate metabolism_Homo sapiens_hsa00650	1.82329907
22	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.81317084
23	Bile secretion_Homo sapiens_hsa04976	1.69196978
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.68885767
25	PPAR signaling pathway_Homo sapiens_hsa03320	1.53025081
26	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.51088624
27	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.49882273
28	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.42941882
29	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.39482891
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38743758
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.37035079
32	Fat digestion and absorption_Homo sapiens_hsa04975	1.34554434
33	Peroxisome_Homo sapiens_hsa04146	1.21248680
34	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.12507863
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.10254073
36	Fatty acid metabolism_Homo sapiens_hsa01212	1.08103701
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.06936860
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.04517499
39	ABC transporters_Homo sapiens_hsa02010	1.04133458
40	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.01818541
41	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.99513771
42	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.99472790
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.98796058
44	Propanoate metabolism_Homo sapiens_hsa00640	0.96799075
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.96292883
46	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.95730491
47	Prion diseases_Homo sapiens_hsa05020	0.95661036
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.90626839
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.88310739
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.85001011
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82212663
52	One carbon pool by folate_Homo sapiens_hsa00670	0.81199729
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79842855
54	Carbon metabolism_Homo sapiens_hsa01200	0.75133284
55	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.60693373
56	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.60535450
57	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.59075162
58	Lysine degradation_Homo sapiens_hsa00310	0.56372936
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.54841046
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.46743766
61	Metabolic pathways_Homo sapiens_hsa01100	0.40954137
62	Pertussis_Homo sapiens_hsa05133	0.39390548
63	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.37046271
64	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.35254022
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34894973
66	Insulin resistance_Homo sapiens_hsa04931	0.30325706
67	Other glycan degradation_Homo sapiens_hsa00511	0.26001770
68	Fatty acid elongation_Homo sapiens_hsa00062	0.23247323
69	Glucagon signaling pathway_Homo sapiens_hsa04922	0.23103179
70	Sulfur metabolism_Homo sapiens_hsa00920	0.20398580
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.20282608
72	Renin-angiotensin system_Homo sapiens_hsa04614	0.17262589
73	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.14948640
74	Glutathione metabolism_Homo sapiens_hsa00480	0.13768757
75	Pentose phosphate pathway_Homo sapiens_hsa00030	0.11515074
76	Nitrogen metabolism_Homo sapiens_hsa00910	0.09942078
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.09903114
78	Sulfur relay system_Homo sapiens_hsa04122	0.09859109
79	Galactose metabolism_Homo sapiens_hsa00052	0.08427334
80	Mineral absorption_Homo sapiens_hsa04978	0.04373047
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.03655953
82	AMPK signaling pathway_Homo sapiens_hsa04152	0.03411197
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.03273491
84	Circadian rhythm_Homo sapiens_hsa04710	0.00958948
85	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	-0.2156057
86	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	-0.2124049
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.2057764
88	ECM-receptor interaction_Homo sapiens_hsa04512	-0.2054248
89	Serotonergic synapse_Homo sapiens_hsa04726	-0.2051016
90	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1882865
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.1375203
92	Amoebiasis_Homo sapiens_hsa05146	-0.1301848
93	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.0935970
94	Insulin signaling pathway_Homo sapiens_hsa04910	-0.0913202
95	African trypanosomiasis_Homo sapiens_hsa05143	-0.0861920
96	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.0859698
97	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0680437
98	Selenocompound metabolism_Homo sapiens_hsa00450	-0.0470646
99	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.0388752
100	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.0316348

UGT2B27P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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