UGT2B28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)9.53680905
2regulation of memory T cell differentiation (GO:0043380)6.84871321
3thrombin receptor signaling pathway (GO:0070493)6.29977561
4neutrophil activation involved in immune response (GO:0002283)5.79604335
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.55462738
6blood coagulation, intrinsic pathway (GO:0007597)5.43327309
7regulation of platelet aggregation (GO:0090330)5.10672704
8regulation of Golgi to plasma membrane protein transport (GO:0042996)5.00539921
9negative regulation of norepinephrine secretion (GO:0010700)4.95939263
10regulation of platelet activation (GO:0010543)4.84395467
11low-density lipoprotein particle remodeling (GO:0034374)4.75605864
12regulation of lipoprotein metabolic process (GO:0050746)4.69728713
13dopamine transport (GO:0015872)4.67587382
14negative regulation of heart rate (GO:0010459)4.58967973
15regulation of triglyceride catabolic process (GO:0010896)4.54790958
16adenosine receptor signaling pathway (GO:0001973)4.47639729
17leukocyte migration involved in inflammatory response (GO:0002523)4.45610528
18negative regulation of homotypic cell-cell adhesion (GO:0034111)4.44130347
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.36464929
20L-phenylalanine catabolic process (GO:0006559)4.36464929
21negative regulation of platelet activation (GO:0010544)4.31821313
22regulation of integrin-mediated signaling pathway (GO:2001044)4.09100614
23regulation of interleukin-13 production (GO:0032656)4.08111458
24tyrosine metabolic process (GO:0006570)4.00914549
25negative regulation of protein localization to cell surface (GO:2000009)3.98984042
26positive regulation of endothelial cell differentiation (GO:0045603)3.97652723
27platelet aggregation (GO:0070527)3.89980168
28negative regulation of appetite (GO:0032099)3.89665087
29negative regulation of response to food (GO:0032096)3.89665087
30high-density lipoprotein particle remodeling (GO:0034375)3.88184293
31lipoxygenase pathway (GO:0019372)3.85396116
32negative regulation of thymocyte apoptotic process (GO:0070244)3.82867630
33negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.80048008
34positive regulation of systemic arterial blood pressure (GO:0003084)3.78787194
35regulation of establishment of cell polarity (GO:2000114)3.73359679
36aromatic amino acid family catabolic process (GO:0009074)3.72454688
37bile acid biosynthetic process (GO:0006699)3.69863293
38amine catabolic process (GO:0009310)3.69352545
39cellular biogenic amine catabolic process (GO:0042402)3.69352545
40G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.69028341
41phospholipid homeostasis (GO:0055091)3.60479751
42reverse cholesterol transport (GO:0043691)3.51855825
43L-phenylalanine metabolic process (GO:0006558)3.51715716
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.51715716
45negative regulation of catecholamine secretion (GO:0033604)3.50953636
46cardiolipin metabolic process (GO:0032048)3.48248921
47neutrophil activation (GO:0042119)3.46968790
48cytoplasmic mRNA processing body assembly (GO:0033962)3.45435999
49negative regulation of multicellular organism growth (GO:0040015)3.44955127
50purinergic nucleotide receptor signaling pathway (GO:0035590)3.40478752
51fusion of sperm to egg plasma membrane (GO:0007342)3.40115369
52positive regulation of mast cell activation (GO:0033005)3.37463311
53fibrinolysis (GO:0042730)3.34706641
54ADP metabolic process (GO:0046031)3.27654967
55regulation of metalloenzyme activity (GO:0048552)3.27452229
56negative regulation of type 2 immune response (GO:0002829)3.26409965
57regulation of norepinephrine secretion (GO:0014061)3.26225367
58platelet degranulation (GO:0002576)3.24431075
59monoamine transport (GO:0015844)3.19488631
60negative regulation of blood coagulation (GO:0030195)3.17543045
61negative regulation of hemostasis (GO:1900047)3.17543045
62indole-containing compound catabolic process (GO:0042436)3.15556696
63indolalkylamine catabolic process (GO:0046218)3.15556696
64tryptophan catabolic process (GO:0006569)3.15556696
65sex differentiation (GO:0007548)3.15514668
66benzene-containing compound metabolic process (GO:0042537)3.15221964
67positive regulation of hemostasis (GO:1900048)3.10750512
68positive regulation of blood coagulation (GO:0030194)3.10750512
69regulation of macrophage derived foam cell differentiation (GO:0010743)3.05150961
70regulation of integrin activation (GO:0033623)3.04604613
71polyamine biosynthetic process (GO:0006596)3.03569409
72vesicle targeting (GO:0006903)3.01318852
73regulation of hemostasis (GO:1900046)3.00331199
74regulation of blood coagulation (GO:0030193)3.00331199
75positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.94465468
76positive regulation of fatty acid beta-oxidation (GO:0032000)2.94150084
77megakaryocyte development (GO:0035855)2.93157433
78catecholamine transport (GO:0051937)2.93111145
79fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.92992592
80regulation of endothelial cell differentiation (GO:0045601)2.92525964
81negative regulation of coagulation (GO:0050819)2.91947418
82regulation of establishment or maintenance of cell polarity (GO:0032878)2.91039213
83regulation of female receptivity (GO:0045924)2.90939044
84granulocyte activation (GO:0036230)2.87902430
85beta-amyloid metabolic process (GO:0050435)2.86952849
86positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.86431624
87negative regulation of heart contraction (GO:0045822)2.84079819
88platelet activation (GO:0030168)2.83639198
89regulation of MHC class I biosynthetic process (GO:0045343)2.83096142
90regulation of inositol phosphate biosynthetic process (GO:0010919)2.82705686
91xenobiotic catabolic process (GO:0042178)2.81970158
92regulation of appetite (GO:0032098)2.79721438
93angiogenesis involved in wound healing (GO:0060055)2.79092931
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.76813075
95platelet formation (GO:0030220)2.76718838
96regulation of homotypic cell-cell adhesion (GO:0034110)2.76150708
97regulation of coagulation (GO:0050818)2.73793217
98purinergic receptor signaling pathway (GO:0035587)2.69055258
99termination of G-protein coupled receptor signaling pathway (GO:0038032)2.68498392
100cholesterol catabolic process (GO:0006707)2.68495684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.22969346
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.76952378
3* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.47521108
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.15315909
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73346691
6SCL_19346495_ChIP-Seq_HPC-7_Human2.68043865
7VDR_22108803_ChIP-Seq_LS180_Human2.56777240
8GBX2_23144817_ChIP-Seq_PC3_Human2.55824885
9GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.37789706
10TAF15_26573619_Chip-Seq_HEK293_Human2.34296164
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32964246
12EZH2_22144423_ChIP-Seq_EOC_Human2.24295047
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.21407801
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20685368
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.12897570
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10178999
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03758992
18HTT_18923047_ChIP-ChIP_STHdh_Human2.01402279
19GATA1_19941826_ChIP-Seq_K562_Human1.96766587
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96598544
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.96485121
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88471931
23LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.86528490
24GATA2_19941826_ChIP-Seq_K562_Human1.86307498
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83336904
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73057347
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70941862
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64663216
29ER_23166858_ChIP-Seq_MCF-7_Human1.60590902
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.60551447
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.60311971
32SALL4_22934838_ChIP-ChIP_CD34+_Human1.56095271
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54142100
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54142100
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.52841137
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47686720
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44866704
38* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43603566
39BCAT_22108803_ChIP-Seq_LS180_Human1.42688823
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.40451883
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40064147
42OCT1_27270436_Chip-Seq_PROSTATE_Human1.31988164
43SPI1_23127762_ChIP-Seq_K562_Human1.31454986
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.30636451
45* AR_25329375_ChIP-Seq_VCAP_Human1.29211128
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.27403111
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26887171
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.25313813
49* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25270026
50ELK4_26923725_Chip-Seq_MESODERM_Mouse1.23720051
51GATA4_25053715_ChIP-Seq_YYC3_Human1.22614690
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21662076
53AR_20517297_ChIP-Seq_VCAP_Human1.21121978
54SOX2_19829295_ChIP-Seq_ESCs_Human1.19229656
55NANOG_19829295_ChIP-Seq_ESCs_Human1.19229656
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.18990109
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17153504
58EWS_26573619_Chip-Seq_HEK293_Human1.16429398
59IRF1_19129219_ChIP-ChIP_H3396_Human1.15267307
60ERG_20517297_ChIP-Seq_VCAP_Human1.14858087
61KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.12949131
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10856709
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.10523546
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10031508
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09483130
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09039913
67GATA3_26560356_Chip-Seq_TH2_Human1.08111858
68* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07990705
69* FOXA1_25329375_ChIP-Seq_VCAP_Human1.07990705
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07966781
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07677418
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07534939
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07425798
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07075186
75TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06538716
76CDX2_22108803_ChIP-Seq_LS180_Human1.06531303
77P53_22387025_ChIP-Seq_ESCs_Mouse1.05966890
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.05333752
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.00729059
80IRF8_27001747_Chip-Seq_BMDM_Mouse0.99199658
81FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98531687
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98410736
83GATA1_19941827_ChIP-Seq_MEL_Mouse0.98127435
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98020140
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97922083
86OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97608503
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95775720
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95625015
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95387640
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.95383106
91STAT3_23295773_ChIP-Seq_U87_Human0.94324565
92FLI1_21867929_ChIP-Seq_TH2_Mouse0.94178395
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.93759549
94IGF1R_20145208_ChIP-Seq_DFB_Human0.92154902
95STAT1_17558387_ChIP-Seq_HELA_Human0.91312024
96FUS_26573619_Chip-Seq_HEK293_Human0.90735178
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.90727166
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.90063743
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89884023
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89591534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.73021345
2MP0008004_abnormal_stomach_pH3.84484295
3MP0003724_increased_susceptibility_to3.30005626
4MP0003252_abnormal_bile_duct3.09873093
5MP0003011_delayed_dark_adaptation2.77183215
6MP0002736_abnormal_nociception_after2.72619646
7MP0000465_gastrointestinal_hemorrhage2.38561077
8MP0004130_abnormal_muscle_cell2.35378860
9MP0009697_abnormal_copulation2.27542278
10MP0000230_abnormal_systemic_arterial2.14715455
11MP0004510_myositis2.09867056
12MP0008872_abnormal_physiological_respon1.94521759
13MP0005410_abnormal_fertilization1.91631589
14MP0001835_abnormal_antigen_presentation1.90732755
15MP0001879_abnormal_lymphatic_vessel1.88057653
16MP0001968_abnormal_touch/_nociception1.83439194
17MP0010329_abnormal_lipoprotein_level1.82325450
18MP0005646_abnormal_pituitary_gland1.80557052
19MP0003638_abnormal_response/metabolism_1.79829848
20MP0006036_abnormal_mitochondrial_physio1.78798938
21MP0001545_abnormal_hematopoietic_system1.73431241
22MP0005397_hematopoietic_system_phenotyp1.73431241
23MP0000343_altered_response_to1.73368285
24MP0005085_abnormal_gallbladder_physiolo1.65950451
25MP0004147_increased_porphyrin_level1.64539387
26MP0010386_abnormal_urinary_bladder1.60398278
27MP0005083_abnormal_biliary_tract1.58058224
28MP0009763_increased_sensitivity_to1.56769738
29MP0003566_abnormal_cell_adhesion1.51085423
30MP0001986_abnormal_taste_sensitivity1.50259328
31MP0005671_abnormal_response_to1.49202568
32MP0005084_abnormal_gallbladder_morpholo1.41560535
33MP0003718_maternal_effect1.37837045
34MP0008875_abnormal_xenobiotic_pharmacok1.36687199
35MP0000569_abnormal_digit_pigmentation1.33568388
36MP0009765_abnormal_xenobiotic_induced1.33280791
37MP0002118_abnormal_lipid_homeostasis1.31179741
38MP0002148_abnormal_hypersensitivity_rea1.30746821
39MP0002733_abnormal_thermal_nociception1.29980108
40MP0005365_abnormal_bile_salt1.28003325
41MP0004215_abnormal_myocardial_fiber1.23943659
42MP0010155_abnormal_intestine_physiology1.23619632
43MP0001666_abnormal_nutrient_absorption1.23506290
44MP0002132_abnormal_respiratory_system1.19971540
45MP0000249_abnormal_blood_vessel1.19277044
46MP0003828_pulmonary_edema1.18260604
47MP0005000_abnormal_immune_tolerance1.17807002
48MP0003186_abnormal_redox_activity1.15543178
49MP0006035_abnormal_mitochondrial_morpho1.14856579
50MP0003303_peritoneal_inflammation1.13322665
51MP0009642_abnormal_blood_homeostasis1.11141242
52MP0005647_abnormal_sex_gland1.07328806
53MP0001851_eye_inflammation1.06194359
54MP0002398_abnormal_bone_marrow1.05854018
55MP0005636_abnormal_mineral_homeostasis1.05651684
56MP0005167_abnormal_blood-brain_barrier1.05183785
57MP0002139_abnormal_hepatobiliary_system1.04998205
58MP0008775_abnormal_heart_ventricle1.02828701
59MP0008961_abnormal_basal_metabolism1.02398078
60MP0004019_abnormal_vitamin_homeostasis0.99258416
61MP0000685_abnormal_immune_system0.98603370
62MP0001756_abnormal_urination0.97940665
63MP0001800_abnormal_humoral_immune0.97347922
64MP0001765_abnormal_ion_homeostasis0.97147086
65MP0003879_abnormal_hair_cell0.95836615
66MP0001663_abnormal_digestive_system0.95804487
67MP0004084_abnormal_cardiac_muscle0.94771086
68MP0005448_abnormal_energy_balance0.93324511
69MP0005310_abnormal_salivary_gland0.92697541
70MP0004947_skin_inflammation0.90898098
71MP0003656_abnormal_erythrocyte_physiolo0.90829622
72MP0006138_congestive_heart_failure0.90643748
73MP0000358_abnormal_cell_content/0.86567145
74MP0006276_abnormal_autonomic_nervous0.86551860
75MP0000689_abnormal_spleen_morphology0.86240705
76MP0002723_abnormal_immune_serum0.86223319
77MP0004036_abnormal_muscle_relaxation0.83360766
78MP0001845_abnormal_inflammatory_respons0.83097992
79MP0003866_abnormal_defecation0.81585008
80MP0002452_abnormal_antigen_presenting0.80595673
81MP0009764_decreased_sensitivity_to0.80536162
82MP0004808_abnormal_hematopoietic_stem0.79631086
83MP0005187_abnormal_penis_morphology0.78096559
84MP0000383_abnormal_hair_follicle0.75921340
85MP0002429_abnormal_blood_cell0.74551567
86MP0001970_abnormal_pain_threshold0.72640193
87MP0001664_abnormal_digestion0.72392249
88MP0002722_abnormal_immune_system0.72170294
89MP0005334_abnormal_fat_pad0.71426720
90MP0001764_abnormal_homeostasis0.71134671
91MP0005332_abnormal_amino_acid0.70394167
92MP0002420_abnormal_adaptive_immunity0.70316626
93MP0001819_abnormal_immune_cell0.69882705
94MP0005551_abnormal_eye_electrophysiolog0.69403682
95MP0001533_abnormal_skeleton_physiology0.68615158
96MP0009643_abnormal_urine_homeostasis0.68254390
97MP0003868_abnormal_feces_composition0.67072239
98MP0009840_abnormal_foam_cell0.66957216
99MP0000609_abnormal_liver_physiology0.66874158
100MP0002693_abnormal_pancreas_physiology0.65853379

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)8.72317162
2Menorrhagia (HP:0000132)7.94946761
3Increased mean platelet volume (HP:0011877)7.69062991
4Abnormal platelet volume (HP:0011876)7.25595129
5Petechiae (HP:0000967)6.84005752
6Purpura (HP:0000979)6.36218259
7Epistaxis (HP:0000421)6.34518063
8Gingival bleeding (HP:0000225)6.24212327
9Hyperlipoproteinemia (HP:0010980)6.22284806
10Impaired platelet aggregation (HP:0003540)4.76931150
11Abnormal platelet function (HP:0011869)4.76931150
12Generalized aminoaciduria (HP:0002909)4.66148184
13Genetic anticipation (HP:0003743)4.13646504
14Dyschromatopsia (HP:0007641)3.91435398
15Dysmetric saccades (HP:0000641)3.86258092
16Poikilocytosis (HP:0004447)3.83988728
17Acanthocytosis (HP:0001927)3.83732119
18Renal cortical cysts (HP:0000803)3.65257842
19Spontaneous hematomas (HP:0007420)3.54136213
20Decreased central vision (HP:0007663)3.42874921
21Abnormality of the common coagulation pathway (HP:0010990)3.36832902
22Abnormal pupillary function (HP:0007686)3.34466362
23Abnormality of the prostate (HP:0008775)3.26046177
24Prostate neoplasm (HP:0100787)3.18366702
25Tinnitus (HP:0000360)3.17552057
26Spontaneous abortion (HP:0005268)3.10946145
27Joint hemorrhage (HP:0005261)3.09623910
28Proximal tubulopathy (HP:0000114)2.95012937
29Abnormality of the hepatic vasculature (HP:0006707)2.85581383
30Pendular nystagmus (HP:0012043)2.85531872
31Progressive cerebellar ataxia (HP:0002073)2.84687356
323-Methylglutaconic aciduria (HP:0003535)2.82930275
33Paralysis (HP:0003470)2.78806472
34Action tremor (HP:0002345)2.76728371
35Bruising susceptibility (HP:0000978)2.75119491
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.64507984
37Conjunctival telangiectasia (HP:0000524)2.61860176
38Hyperthyroidism (HP:0000836)2.58688961
39Biliary tract neoplasm (HP:0100574)2.55409118
40Abnormality of the heme biosynthetic pathway (HP:0010472)2.52743397
41Postural tremor (HP:0002174)2.43292965
42Nausea (HP:0002018)2.42462456
43Abnormal auditory evoked potentials (HP:0006958)2.37241995
44Increased density of long bones (HP:0006392)2.34910484
45Congenital, generalized hypertrichosis (HP:0004540)2.27790323
46Hypochromic microcytic anemia (HP:0004840)2.22999574
47Abnormality of the vasculature of the conjunctiva (HP:0008054)2.22873462
48Abnormality of the renal cortex (HP:0011035)2.22445905
49Absence seizures (HP:0002121)2.21217824
50Abnormality of iron homeostasis (HP:0011031)2.20951531
51Abnormal ciliary motility (HP:0012262)2.20145466
52Joint swelling (HP:0001386)2.17468279
53Abnormality of methionine metabolism (HP:0010901)2.17332037
54Xanthomatosis (HP:0000991)2.16440201
55Gaze-evoked nystagmus (HP:0000640)2.15814308
56Abnormality of alanine metabolism (HP:0010916)2.15579391
57Hyperalaninemia (HP:0003348)2.15579391
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15579391
59Severe visual impairment (HP:0001141)2.13757585
60Fair hair (HP:0002286)2.11981645
61Thyroid-stimulating hormone excess (HP:0002925)1.99868058
62Urinary bladder sphincter dysfunction (HP:0002839)1.96835195
63Impaired vibratory sensation (HP:0002495)1.92244792
64Abnormality of fatty-acid metabolism (HP:0004359)1.90994450
65Abnormality of lateral ventricle (HP:0030047)1.90470355
66Abnormality of transition element cation homeostasis (HP:0011030)1.88671113
67Chronic sinusitis (HP:0011109)1.86868135
68Arterial thrombosis (HP:0004420)1.86853688
69Encephalitis (HP:0002383)1.85092607
70Hypophosphatemic rickets (HP:0004912)1.84608098
71Clumsiness (HP:0002312)1.84169624
72Abnormal spermatogenesis (HP:0008669)1.79594919
73Abnormal number of erythroid precursors (HP:0012131)1.79169581
74Male infertility (HP:0003251)1.78449234
75Dynein arm defect of respiratory motile cilia (HP:0012255)1.77459458
76Absent/shortened dynein arms (HP:0200106)1.77459458
77Autoimmune hemolytic anemia (HP:0001890)1.76524138
78Hypobetalipoproteinemia (HP:0003563)1.76389692
79Hepatosplenomegaly (HP:0001433)1.74831365
80Prolonged partial thromboplastin time (HP:0003645)1.74829352
81Arthropathy (HP:0003040)1.73022656
82Renal Fanconi syndrome (HP:0001994)1.69305696
83Abnormal respiratory motile cilium morphology (HP:0005938)1.69300981
84Abnormal respiratory epithelium morphology (HP:0012253)1.69300981
85Postural instability (HP:0002172)1.68990402
86Abnormality of male internal genitalia (HP:0000022)1.68778053
87Increased serum ferritin (HP:0003281)1.66390739
88Increased IgM level (HP:0003496)1.63923443
89Abnormality of cells of the erythroid lineage (HP:0012130)1.62805437
90Slow saccadic eye movements (HP:0000514)1.62530906
91Portal hypertension (HP:0001409)1.59358800
92Abnormal respiratory motile cilium physiology (HP:0012261)1.59207352
93Obstructive lung disease (HP:0006536)1.58719260
94Chronic obstructive pulmonary disease (HP:0006510)1.58719260
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.57980586
96Abnormal biliary tract morphology (HP:0012440)1.57773709
97Tongue fasciculations (HP:0001308)1.54874986
98Abnormality of urine glucose concentration (HP:0011016)1.54077340
99Glycosuria (HP:0003076)1.54077340
100Abnormality of aromatic amino acid family metabolism (HP:0004338)1.52577654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.31854236
2MST44.91591329
3INSRR3.73929155
4RIPK43.56066108
5OXSR13.44998999
6EIF2AK13.07848091
7BMX3.02423619
8MYLK2.78946388
9TEC2.75936985
10PIK3CG2.53312712
11BTK2.47837147
12BMPR22.34958450
13TNK22.23575653
14TAOK32.12776317
15FRK2.04920838
16BMPR1B1.90307313
17PTK2B1.86961303
18ACVR1B1.82390061
19CSF1R1.80916968
20GRK51.67646641
21MAP4K21.57718701
22ILK1.51735475
23TXK1.50403312
24SYK1.46933082
25STK31.46856803
26ADRBK21.42959894
27GRK61.35441381
28BRSK21.26641028
29MUSK1.25718814
30MAPKAPK31.20665907
31GRK11.19850062
32ZAP701.16856124
33CDK81.14287396
34FGR1.12302279
35RPS6KB21.00880730
36VRK10.94328661
37ADRBK10.91722056
38FER0.86588983
39HCK0.85642073
40STK160.85324084
41LYN0.83186462
42DAPK30.82974368
43TLK10.80587926
44ITK0.78842972
45ZAK0.76347663
46IKBKB0.76342414
47RET0.75459248
48FES0.74444699
49PAK10.74064254
50DAPK20.71079820
51PLK20.65979861
52MATK0.65870672
53NUAK10.65613187
54STK240.64032423
55NEK90.63721792
56JAK20.63513310
57PDK10.62745013
58TGFBR10.60377101
59STK390.59780299
60BLK0.56677405
61PDGFRB0.55568154
62MAP3K120.55492392
63LMTK20.55343189
64CAMKK20.54743709
65ERBB20.53747110
66EPHA30.51730620
67WNK40.51522934
68TRPM70.50266330
69PDPK10.49199828
70PAK20.48530293
71MKNK10.48456188
72CDK90.48287660
73PRKACG0.45644442
74MAP3K50.41976482
75MKNK20.39761898
76PIM20.39210337
77IGF1R0.38103447
78LCK0.37823571
79PNCK0.37684141
80MAP2K10.36978353
81PRKCD0.36503698
82PAK30.36204052
83PRKG10.33760702
84IRAK10.33230231
85AURKA0.32861858
86PIK3CA0.31413144
87MAP2K30.27643732
88MARK30.27305996
89MAPK110.26924216
90PRKD10.25976757
91ERBB30.22797270
92HIPK20.21820926
93JAK10.21438089
94STK40.19894881
95PRKCB0.19630821
96PRKAA20.18822221
97PRKCA0.17524336
98PKN10.17111350
99PRKACA0.16947925
100PLK30.16072824

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001205.20057223
2Platelet activation_Homo sapiens_hsa046114.18898041
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.79354715
4Arachidonic acid metabolism_Homo sapiens_hsa005902.89189428
5Linoleic acid metabolism_Homo sapiens_hsa005912.74779977
6* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.65196357
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.54958132
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.51961336
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.48729727
10Caffeine metabolism_Homo sapiens_hsa002322.00852029
11Butanoate metabolism_Homo sapiens_hsa006501.98343172
12* Steroid hormone biosynthesis_Homo sapiens_hsa001401.96067604
13Renin-angiotensin system_Homo sapiens_hsa046141.94452749
14* Retinol metabolism_Homo sapiens_hsa008301.88067091
15* Chemical carcinogenesis_Homo sapiens_hsa052041.87947624
16Nitrogen metabolism_Homo sapiens_hsa009101.78809704
17* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72006173
18* Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58983172
19Complement and coagulation cascades_Homo sapiens_hsa046101.55942400
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48700349
21Hematopoietic cell lineage_Homo sapiens_hsa046401.42957290
22Sulfur metabolism_Homo sapiens_hsa009201.41457624
23Collecting duct acid secretion_Homo sapiens_hsa049661.38646428
24Serotonergic synapse_Homo sapiens_hsa047261.32037165
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31655039
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.30341759
27* Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28477303
28Systemic lupus erythematosus_Homo sapiens_hsa053221.25095868
29Tyrosine metabolism_Homo sapiens_hsa003501.23548848
30Fatty acid biosynthesis_Homo sapiens_hsa000611.23097325
31ECM-receptor interaction_Homo sapiens_hsa045121.19298065
32Ribosome_Homo sapiens_hsa030101.18475117
33Glutathione metabolism_Homo sapiens_hsa004801.15423307
34PPAR signaling pathway_Homo sapiens_hsa033201.08854563
35* Starch and sucrose metabolism_Homo sapiens_hsa005001.07920110
36Peroxisome_Homo sapiens_hsa041461.07202662
37Olfactory transduction_Homo sapiens_hsa047401.05697434
38Chemokine signaling pathway_Homo sapiens_hsa040621.03040080
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99283423
40Tryptophan metabolism_Homo sapiens_hsa003800.89953778
41* Drug metabolism - other enzymes_Homo sapiens_hsa009830.89421503
42* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88308752
43Ether lipid metabolism_Homo sapiens_hsa005650.88155693
44Alcoholism_Homo sapiens_hsa050340.87983216
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87978695
46Gap junction_Homo sapiens_hsa045400.86801195
47Vitamin digestion and absorption_Homo sapiens_hsa049770.86430946
48ABC transporters_Homo sapiens_hsa020100.84812609
49Phototransduction_Homo sapiens_hsa047440.84682706
50Pancreatic secretion_Homo sapiens_hsa049720.83855792
51beta-Alanine metabolism_Homo sapiens_hsa004100.81396667
52Glycerolipid metabolism_Homo sapiens_hsa005610.80833486
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80410837
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78399841
55Parkinsons disease_Homo sapiens_hsa050120.76829902
56Fatty acid degradation_Homo sapiens_hsa000710.74300584
57Regulation of autophagy_Homo sapiens_hsa041400.73391114
58Oxidative phosphorylation_Homo sapiens_hsa001900.72780920
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71657979
60Bile secretion_Homo sapiens_hsa049760.69075339
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69028993
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.66208351
63B cell receptor signaling pathway_Homo sapiens_hsa046620.62435872
64Fat digestion and absorption_Homo sapiens_hsa049750.60880190
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60756060
66Purine metabolism_Homo sapiens_hsa002300.55888938
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51003052
68Basal transcription factors_Homo sapiens_hsa030220.48007481
69Nucleotide excision repair_Homo sapiens_hsa034200.47511944
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46305406
71Long-term depression_Homo sapiens_hsa047300.45803953
72Fatty acid elongation_Homo sapiens_hsa000620.44394666
73Histidine metabolism_Homo sapiens_hsa003400.44375503
74Morphine addiction_Homo sapiens_hsa050320.43601810
75Endocytosis_Homo sapiens_hsa041440.42714397
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.42603997
77One carbon pool by folate_Homo sapiens_hsa006700.42253677
78Staphylococcus aureus infection_Homo sapiens_hsa051500.41000939
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.40982856
80Calcium signaling pathway_Homo sapiens_hsa040200.40561272
81Taste transduction_Homo sapiens_hsa047420.40544550
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40393375
83T cell receptor signaling pathway_Homo sapiens_hsa046600.38636659
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36377070
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.35048789
86Renal cell carcinoma_Homo sapiens_hsa052110.34744539
87Propanoate metabolism_Homo sapiens_hsa006400.33522527
88Choline metabolism in cancer_Homo sapiens_hsa052310.32341169
89* Metabolic pathways_Homo sapiens_hsa011000.31860929
90Melanoma_Homo sapiens_hsa052180.30737426
91Arginine and proline metabolism_Homo sapiens_hsa003300.30346796
92Sphingolipid metabolism_Homo sapiens_hsa006000.29793414
93Sulfur relay system_Homo sapiens_hsa041220.28097354
94Mismatch repair_Homo sapiens_hsa034300.28035773
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.27760913
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27373911
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.25629531
98Renin secretion_Homo sapiens_hsa049240.23838853
99Homologous recombination_Homo sapiens_hsa034400.23724875
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.23632924

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