ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	exogenous drug catabolic process (GO:0042738)	9.23322938
2	drug catabolic process (GO:0042737)	8.84846025
3	negative regulation of fibrinolysis (GO:0051918)	8.41897720
4	complement activation, alternative pathway (GO:0006957)	8.36554411
5	regulation of fibrinolysis (GO:0051917)	8.32115677
6	glyoxylate metabolic process (GO:0046487)	8.12884602
7	regulation of protein activation cascade (GO:2000257)	7.86304771
8	epoxygenase P450 pathway (GO:0019373)	7.80041037
9	L-phenylalanine catabolic process (GO:0006559)	7.58999716
10	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.58999716
11	omega-hydroxylase P450 pathway (GO:0097267)	7.53893144
12	regulation of complement activation (GO:0030449)	7.29342870
13	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.01214946
14	L-phenylalanine metabolic process (GO:0006558)	7.01214946
15	urea metabolic process (GO:0019627)	6.94861325
16	* cellular glucuronidation (GO:0052695)	6.75110606
17	fibrinolysis (GO:0042730)	6.70672516
18	* uronic acid metabolic process (GO:0006063)	6.41433366
19	* glucuronate metabolic process (GO:0019585)	6.41433366
20	nitrogen cycle metabolic process (GO:0071941)	6.32690021
21	protein carboxylation (GO:0018214)	6.18712287
22	peptidyl-glutamic acid carboxylation (GO:0017187)	6.18712287
23	bile acid biosynthetic process (GO:0006699)	6.10797597
24	drug metabolic process (GO:0017144)	6.00521774
25	oxidative demethylation (GO:0070989)	5.95419553
26	blood coagulation, intrinsic pathway (GO:0007597)	5.94165808
27	ethanol oxidation (GO:0006069)	5.86128518
28	urea cycle (GO:0000050)	5.77846961
29	negative regulation of sterol transport (GO:0032372)	5.70484148
30	negative regulation of cholesterol transport (GO:0032375)	5.70484148
31	bile acid metabolic process (GO:0008206)	5.61164496
32	aromatic amino acid family catabolic process (GO:0009074)	5.56752845
33	serine family amino acid catabolic process (GO:0009071)	5.48307939
34	regulation of triglyceride catabolic process (GO:0010896)	5.46517305
35	phenylpropanoid metabolic process (GO:0009698)	5.36623543
36	bile acid and bile salt transport (GO:0015721)	5.27971169
37	glycine metabolic process (GO:0006544)	5.09540461
38	regulation of plasminogen activation (GO:0010755)	5.03135927
39	protein activation cascade (GO:0072376)	5.00453016
40	negative regulation of blood coagulation (GO:0030195)	4.98779923
41	negative regulation of hemostasis (GO:1900047)	4.98779923
42	polyketide metabolic process (GO:0030638)	4.93000448
43	doxorubicin metabolic process (GO:0044598)	4.93000448
44	daunorubicin metabolic process (GO:0044597)	4.93000448
45	ethanol metabolic process (GO:0006067)	4.72473125
46	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.70325961
47	negative regulation of protein activation cascade (GO:2000258)	4.69714032
48	complement activation (GO:0006956)	4.67584974
49	triglyceride homeostasis (GO:0070328)	4.63903800
50	acylglycerol homeostasis (GO:0055090)	4.63903800
51	phospholipid efflux (GO:0033700)	4.61501892
52	amino-acid betaine metabolic process (GO:0006577)	4.59078938
53	regulation of humoral immune response (GO:0002920)	4.58974115
54	negative regulation of wound healing (GO:0061045)	4.55110405
55	S-adenosylmethionine metabolic process (GO:0046500)	4.53559342
56	acute-phase response (GO:0006953)	4.53414089
57	negative regulation of coagulation (GO:0050819)	4.53289164
58	complement activation, classical pathway (GO:0006958)	4.47176118
59	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.41824069
60	alkaloid metabolic process (GO:0009820)	4.41688669
61	aminoglycoside antibiotic metabolic process (GO:0030647)	4.38198800
62	positive regulation of blood coagulation (GO:0030194)	4.23505465
63	positive regulation of hemostasis (GO:1900048)	4.23505465
64	tyrosine metabolic process (GO:0006570)	4.18199169
65	flavonoid metabolic process (GO:0009812)	4.16326634
66	regulation of cholesterol esterification (GO:0010872)	4.15469131
67	positive regulation of triglyceride lipase activity (GO:0061365)	4.15329316
68	positive regulation of lipoprotein lipase activity (GO:0051006)	4.15329316
69	negative regulation of lipase activity (GO:0060192)	4.15107542
70	heme transport (GO:0015886)	4.11192961
71	plasma lipoprotein particle remodeling (GO:0034369)	4.10780020
72	protein-lipid complex remodeling (GO:0034368)	4.10780020
73	macromolecular complex remodeling (GO:0034367)	4.10780020
74	serine family amino acid metabolic process (GO:0009069)	4.10280146
75	high-density lipoprotein particle remodeling (GO:0034375)	4.00251425
76	arginine metabolic process (GO:0006525)	3.99443956
77	intestinal cholesterol absorption (GO:0030299)	3.95823063
78	cholesterol efflux (GO:0033344)	3.95719494
79	primary alcohol catabolic process (GO:0034310)	3.94925168
80	cytolysis (GO:0019835)	3.91696805
81	positive regulation of coagulation (GO:0050820)	3.90712812
82	imidazole-containing compound metabolic process (GO:0052803)	3.85692713
83	response to mercury ion (GO:0046689)	3.78781460
84	fat-soluble vitamin biosynthetic process (GO:0042362)	3.78660313
85	indole-containing compound catabolic process (GO:0042436)	3.76977848
86	indolalkylamine catabolic process (GO:0046218)	3.76977848
87	tryptophan catabolic process (GO:0006569)	3.76977848
88	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.75082458
89	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.75082458
90	opsonization (GO:0008228)	3.72712628
91	regulation of lipoprotein particle clearance (GO:0010984)	3.72353586
92	very-low-density lipoprotein particle assembly (GO:0034379)	3.71986622
93	negative regulation of complement activation (GO:0045916)	3.70710831
94	alpha-amino acid catabolic process (GO:1901606)	3.70505655
95	aromatic amino acid family metabolic process (GO:0009072)	3.62025144
96	sodium-independent organic anion transport (GO:0043252)	3.59813367
97	reverse cholesterol transport (GO:0043691)	3.56445039
98	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.55574844
99	* xenobiotic metabolic process (GO:0006805)	3.54659875
100	drug transmembrane transport (GO:0006855)	3.54255174

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EGR1_23403033_ChIP-Seq_LIVER_Mouse	7.13992919
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.00217948
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.85613233
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.63289088
5	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.90737444
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.88809269
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.30403157
8	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	4.26651747
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	4.09121171
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.41800535
11	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.16689150
12	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.11293783
13	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.10230288
14	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.01273033
15	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.1294378
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.75062772
17	HTT_18923047_ChIP-ChIP_STHdh_Human	1.69947091
18	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.62265001
19	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.40798115
20	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.24578275
21	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.21413527
22	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.20554239
23	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.16930818
24	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14851521
25	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.12538642
26	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.08731502
27	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.06807241
28	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.01991181
29	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.00877698
30	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.97715346
31	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96790498
32	PHF8_20622853_ChIP-Seq_HELA_Human	0.96202221
33	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.95955269
34	GATA4_25053715_ChIP-Seq_YYC3_Human	0.94831550
35	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.92990692
36	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.91423570
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.90890191
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.88844033
39	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.87483362
40	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.86448404
41	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.86389839
42	NFYA_21822215_ChIP-Seq_K562_Human	0.85621223
43	IRF1_19129219_ChIP-ChIP_H3396_Human	0.84850200
44	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.83214062
45	CBP_21632823_ChIP-Seq_H3396_Human	0.82751893
46	GATA1_22025678_ChIP-Seq_K562_Human	0.80913052
47	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.80432668
48	TP53_18474530_ChIP-ChIP_U2OS_Human	0.79030138
49	CEBPB_22108803_ChIP-Seq_LS180_Human	0.78926354
50	BCAT_22108803_ChIP-Seq_LS180_Human	0.77875597
51	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.77144581
52	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.77011015
53	* FOXA1_25552417_ChIP-Seq_VCAP_Human	0.76790048
54	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.75721654
55	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.75072406
56	AR_20517297_ChIP-Seq_VCAP_Human	0.74862026
57	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.74199501
58	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.73561576
59	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.72057961
60	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.71908440
61	GATA6_25053715_ChIP-Seq_YYC3_Human	0.71710065
62	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.71149613
63	SOX2_21211035_ChIP-Seq_LN229_Human	0.70238036
64	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.70049377
65	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.69919373
66	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.69056002
67	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.68643871
68	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.68116332
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.67980513
70	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.67321850
71	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.66815750
72	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.66815750
73	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.66689224
74	ETV1_20927104_ChIP-Seq_GIST48_Human	0.66157845
75	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.66081960
76	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.65100038
77	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.64660063
78	* ER_23166858_ChIP-Seq_MCF-7_Human	0.63768910
79	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.63221331
80	SOX2_20726797_ChIP-Seq_SW620_Human	0.62068429
81	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.61906552
82	NFYB_21822215_ChIP-Seq_K562_Human	0.61134941
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.61018476
84	PU1_27457419_Chip-Seq_LIVER_Mouse	0.59859263
85	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.58470581
86	P53_21459846_ChIP-Seq_SAOS-2_Human	0.58436808
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.57581831
88	CDX2_22108803_ChIP-Seq_LS180_Human	0.56728718
89	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.56708840
90	SPI1_20517297_ChIP-Seq_HL60_Human	0.56152134
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.55977798
92	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.55899117
93	RBPJ_21746931_ChIP-Seq_IB4_Human	0.53632424
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.53520350
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.53520350
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.53147091
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.53048300
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.52662205
99	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.52541337
100	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.52533887

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005085_abnormal_gallbladder_physiolo	6.43753899
2	MP0005365_abnormal_bile_salt	6.07247398
3	MP0005360_urolithiasis	5.91855730
4	MP0008875_abnormal_xenobiotic_pharmacok	5.28807657
5	MP0002138_abnormal_hepatobiliary_system	4.85650112
6	MP0003195_calcinosis	4.84355387
7	MP0003252_abnormal_bile_duct	4.45283836
8	MP0003868_abnormal_feces_composition	3.77731982
9	MP0001666_abnormal_nutrient_absorption	3.30938625
10	MP0009697_abnormal_copulation	3.01063049
11	MP0010329_abnormal_lipoprotein_level	2.68745817
12	MP0009840_abnormal_foam_cell	2.30759525
13	MP0005332_abnormal_amino_acid	2.29677253
14	MP0003806_abnormal_nucleotide_metabolis	2.29318267
15	MP0002876_abnormal_thyroid_physiology	2.23002681
16	MP0002139_abnormal_hepatobiliary_system	10.0522757
17	MP0003191_abnormal_cellular_cholesterol	1.89516922
18	MP0000609_abnormal_liver_physiology	1.86355070
19	MP0002118_abnormal_lipid_homeostasis	1.68880238
20	MP0001764_abnormal_homeostasis	1.67033287
21	MP0010368_abnormal_lymphatic_system	1.34593320
22	MP0005408_hypopigmentation	1.31270845
23	MP0004019_abnormal_vitamin_homeostasis	1.30382349
24	MP0001661_extended_life_span	1.27946458
25	MP0005319_abnormal_enzyme/_coenzyme	1.21551901
26	MP0009053_abnormal_anal_canal	1.09985557
27	MP0000598_abnormal_liver_morphology	1.04213285
28	MP0005584_abnormal_enzyme/coenzyme_acti	1.02531830
29	MP0009643_abnormal_urine_homeostasis	0.96579708
30	MP0003186_abnormal_redox_activity	0.94710143
31	MP0000604_amyloidosis	0.93230525
32	MP0005187_abnormal_penis_morphology	0.92003959
33	MP0003656_abnormal_erythrocyte_physiolo	0.91133520
34	MP0001915_intracranial_hemorrhage	0.84319321
35	MP0009642_abnormal_blood_homeostasis	0.83596300
36	MP0005451_abnormal_body_composition	0.83101220
37	MP0002132_abnormal_respiratory_system	0.82831973
38	MP0008469_abnormal_protein_level	0.82684536
39	MP0005670_abnormal_white_adipose	0.81877109
40	MP0005376_homeostasis/metabolism_phenot	0.81746964
41	MP0009763_increased_sensitivity_to	0.79642518
42	MP0009764_decreased_sensitivity_to	0.76428412
43	MP0002971_abnormal_brown_adipose	0.74235296
44	MP0005395_other_phenotype	0.72208105
45	MP0003011_delayed_dark_adaptation	0.72000937
46	MP0005636_abnormal_mineral_homeostasis	0.71710979
47	MP0005464_abnormal_platelet_physiology	0.70448894
48	MP0003638_abnormal_response/metabolism_	0.67484010
49	MP0003690_abnormal_glial_cell	0.66035740
50	MP0003879_abnormal_hair_cell	0.63578375
51	MP0002168_other_aberrant_phenotype	0.62152381
52	MP0005535_abnormal_body_temperature	0.58104369
53	MP0002078_abnormal_glucose_homeostasis	0.55838025
54	MP0005266_abnormal_metabolism	0.54632294
55	MP0008874_decreased_physiological_sensi	0.52987123
56	MP0005023_abnormal_wound_healing	0.51992284
57	MP0002282_abnormal_trachea_morphology	0.51356798
58	MP0005334_abnormal_fat_pad	0.46763079
59	MP0006036_abnormal_mitochondrial_physio	0.45812745
60	MP0009785_altered_susceptibility_to	0.44584645
61	MP0008872_abnormal_physiological_respon	0.41638278
62	MP0003959_abnormal_lean_body	0.41269073
63	MP0005164_abnormal_response_to	0.40540012
64	MP0000249_abnormal_blood_vessel	0.39932929
65	MP0002249_abnormal_larynx_morphology	0.38785355
66	MP0005058_abnormal_lysosome_morphology	0.37986703
67	MP0004883_abnormal_blood_vessel	0.34643043
68	MP0004130_abnormal_muscle_cell	0.32575299
69	MP0002136_abnormal_kidney_physiology	0.32237982
70	MP0002928_abnormal_bile_duct	0.31484803
71	MP0005647_abnormal_sex_gland	0.31314866
72	MP0009765_abnormal_xenobiotic_induced	0.29504407
73	MP0005220_abnormal_exocrine_pancreas	0.28879802
74	MP0005448_abnormal_energy_balance	0.28554534
75	MP0003953_abnormal_hormone_level	0.26434212
76	MP0005166_decreased_susceptibility_to	0.26288538
77	MP0009115_abnormal_fat_cell	0.25260733
78	MP0005197_abnormal_uvea_morphology	0.24770627
79	MP0003718_maternal_effect	0.24624904
80	MP0000920_abnormal_myelination	0.24304294
81	MP0008873_increased_physiological_sensi	0.24293696
82	MP0001851_eye_inflammation	0.23921252
83	MP0005084_abnormal_gallbladder_morpholo	0.22464314
84	MP0001845_abnormal_inflammatory_respons	0.22295712
85	MP0000467_abnormal_esophagus_morphology	0.21958120
86	MP0001756_abnormal_urination	0.21921039
87	MP0003632_abnormal_nervous_system	0.21759144
88	MP0003075_altered_response_to	0.21159137
89	MP0002090_abnormal_vision	0.20091989
90	MP0003633_abnormal_nervous_system	0.19590483
91	MP0000566_synostosis	0.19514845
92	MP0004142_abnormal_muscle_tone	0.19234926
93	MP0006035_abnormal_mitochondrial_morpho	0.18488833
94	MP0002970_abnormal_white_adipose	0.18140246
95	MP0005645_abnormal_hypothalamus_physiol	0.18072044
96	MP0002128_abnormal_blood_circulation	0.17452583
97	MP0003631_nervous_system_phenotype	0.16806206
98	MP0010386_abnormal_urinary_bladder	0.16511893
99	MP0004782_abnormal_surfactant_physiolog	0.15973123
100	MP0004272_abnormal_basement_membrane	0.15353380

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Complement deficiency (HP:0004431)	9.38638072
2	Prolonged partial thromboplastin time (HP:0003645)	8.51619046
3	Hypobetalipoproteinemia (HP:0003563)	8.02983983
4	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.83247324
5	Abnormality of complement system (HP:0005339)	7.58881123
6	Conjugated hyperbilirubinemia (HP:0002908)	7.31096097
7	Systemic lupus erythematosus (HP:0002725)	5.96850828
8	Glomerulonephritis (HP:0000099)	5.86112463
9	Joint hemorrhage (HP:0005261)	5.78206299
10	Intrahepatic cholestasis (HP:0001406)	5.65527903
11	Abnormality of the common coagulation pathway (HP:0010990)	5.55881564
12	Hyperlipoproteinemia (HP:0010980)	5.26880104
13	Abnormality of pyrimidine metabolism (HP:0004353)	4.90779256
14	Spontaneous abortion (HP:0005268)	4.82014421
15	Xanthomatosis (HP:0000991)	4.73627606
16	Hypolipoproteinemia (HP:0010981)	4.59130236
17	Recurrent gram-negative bacterial infections (HP:0005420)	4.13629636
18	Nephritis (HP:0000123)	4.11112692
19	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.93592367
20	Fat malabsorption (HP:0002630)	3.82010922
21	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.74331413
22	Abnormality of the intrinsic pathway (HP:0010989)	3.66801588
23	Generalized aminoaciduria (HP:0002909)	3.38859212
24	Gingival bleeding (HP:0000225)	3.31405128
25	Hyperammonemia (HP:0001987)	3.29747850
26	Hyperglycinemia (HP:0002154)	3.26175670
27	Rickets (HP:0002748)	3.13761050
28	Steatorrhea (HP:0002570)	3.07593932
29	Osteomalacia (HP:0002749)	2.95833721
30	Abnormality of methionine metabolism (HP:0010901)	2.94213382
31	Hypoalphalipoproteinemia (HP:0003233)	2.90699859
32	Hypercholesterolemia (HP:0003124)	2.85076475
33	Vascular calcification (HP:0004934)	2.83231023
34	Mitral stenosis (HP:0001718)	2.83023694
35	Hyperbilirubinemia (HP:0002904)	2.76978376
36	Delayed CNS myelination (HP:0002188)	2.76963513
37	Abnormality of serine family amino acid metabolism (HP:0010894)	2.72675662
38	Abnormality of glycine metabolism (HP:0010895)	2.72675662
39	Abnormality of nucleobase metabolism (HP:0010932)	2.72674267
40	Hemorrhage of the eye (HP:0011885)	2.64687283
41	Thrombophlebitis (HP:0004418)	2.64191436
42	Reduced antithrombin III activity (HP:0001976)	2.63736133
43	Abnormality of serum amino acid levels (HP:0003112)	2.58852494
44	Purpura (HP:0000979)	2.57879439
45	Epidermoid cyst (HP:0200040)	2.52962675
46	Hepatocellular carcinoma (HP:0001402)	2.51331223
47	Hyperglycinuria (HP:0003108)	2.51050806
48	Cardiovascular calcification (HP:0011915)	2.50364075
49	Abnormal gallbladder physiology (HP:0012438)	2.41247450
50	Cholecystitis (HP:0001082)	2.41247450
51	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.39863470
52	Pulmonary embolism (HP:0002204)	2.38570856
53	Fair hair (HP:0002286)	2.32819737
54	Menorrhagia (HP:0000132)	2.31184417
55	Hyperphosphaturia (HP:0003109)	2.25836009
56	Abnormality of vitamin metabolism (HP:0100508)	2.23724992
57	Cholelithiasis (HP:0001081)	2.20883619
58	Glycosuria (HP:0003076)	2.15455526
59	Abnormality of urine glucose concentration (HP:0011016)	2.15455526
60	Abnormal gallbladder morphology (HP:0012437)	2.10683718
61	Metabolic acidosis (HP:0001942)	2.09457103
62	Arthropathy (HP:0003040)	2.07716612
63	Elevated alkaline phosphatase (HP:0003155)	2.07482936
64	Joint swelling (HP:0001386)	2.07280113
65	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.05557521
66	Abnormality of the Achilles tendon (HP:0005109)	2.00906659
67	Abnormality of monocarboxylic acid metabolism (HP:0010996)	10.2312902
68	Deep venous thrombosis (HP:0002625)	10.0108129
69	Irritability (HP:0000737)	1.99343659
70	Bifid scrotum (HP:0000048)	1.95384533
71	Abnormal enzyme/coenzyme activity (HP:0012379)	1.91658446
72	Abnormal biliary tract physiology (HP:0012439)	1.90673286
73	Bile duct proliferation (HP:0001408)	1.90673286
74	Neonatal hypoglycemia (HP:0001998)	1.86727424
75	Abnormality of alkaline phosphatase activity (HP:0004379)	1.86468550
76	Abnormality of iron homeostasis (HP:0011031)	1.85420359
77	Increased serum ferritin (HP:0003281)	1.83758664
78	Myocardial infarction (HP:0001658)	1.82820705
79	Abnormal urine phosphate concentration (HP:0012599)	1.81983034
80	Gangrene (HP:0100758)	1.81387918
81	Hypochromic microcytic anemia (HP:0004840)	1.81192833
82	Abnormality of proline metabolism (HP:0010907)	1.79145091
83	Hydroxyprolinuria (HP:0003080)	1.79145091
84	Ketosis (HP:0001946)	1.78057381
85	Hypophosphatemic rickets (HP:0004912)	1.78027912
86	Poikilocytosis (HP:0004447)	1.73187540
87	Abnormality of purine metabolism (HP:0004352)	1.72709481
88	Abnormality of transition element cation homeostasis (HP:0011030)	1.70958531
89	Increased mean platelet volume (HP:0011877)	1.68849592
90	Epistaxis (HP:0000421)	1.68297671
91	Cerebral palsy (HP:0100021)	1.67746838
92	Abnormal delivery (HP:0001787)	1.61705607
93	Pancreatitis (HP:0001733)	1.59651731
94	Lethargy (HP:0001254)	1.58296091
95	Generalized hypopigmentation of hair (HP:0011358)	1.58237091
96	Sensorimotor neuropathy (HP:0007141)	1.55281776
97	Abnormality of the gallbladder (HP:0005264)	1.54911020
98	Atrioventricular block (HP:0001678)	1.54786216
99	Abnormality of fatty-acid metabolism (HP:0004359)	1.51066504
100	Alkalosis (HP:0001948)	1.50780868

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIK3CG	5.14602304
2	ERN1	4.60458725
3	FGFR4	3.74429943
4	RIPK1	3.17854255
5	PRKACG	2.30873238
6	TYK2	2.29187077
7	PIK3CA	2.19058782
8	BCKDK	2.10260228
9	EPHA3	2.03852826
10	TBK1	1.95730394
11	FGFR3	1.87095126
12	SIK1	1.79317326
13	PRKAA2	1.78175887
14	MAP3K12	1.76935800
15	MAP3K3	1.75919966
16	MST1R	1.74160973
17	PRKCG	1.74050444
18	IRAK3	1.70215323
19	MAPK11	1.69940374
20	MAP2K4	1.69306884
21	NEK9	1.67585935
22	PINK1	1.56189369
23	TRIB3	1.53978374
24	ABL2	1.52967655
25	FRK	1.52502648
26	PRPF4B	1.51517227
27	NTRK3	1.50067715
28	MYLK	1.49930800
29	IGF1R	1.36588258
30	ERBB4	1.34900381
31	TAOK3	1.32414364
32	MAP3K2	1.25422089
33	JAK1	1.23336606
34	PDPK1	1.17904705
35	NLK	1.12567638
36	CAMKK2	1.07222440
37	MET	1.06998451
38	PRKCZ	1.05437528
39	ICK	1.05356108
40	FER	1.00973496
41	SCYL2	0.99729581
42	PRKG1	0.98710832
43	JAK2	0.95937918
44	PRKAA1	0.93371088
45	ZAP70	0.89352980
46	ERBB2	0.88295730
47	PRKACA	0.87087776
48	TNK2	0.86184605
49	CASK	0.84267780
50	INSRR	0.82185323
51	PDK1	0.81903590
52	MAP3K1	0.81654655
53	CSNK1D	0.81603257
54	EPHA4	0.79240358
55	EIF2AK1	0.76956040
56	STK38	0.72687954
57	ACVR1B	0.71876885
58	PRKCB	0.69616726
59	MAP3K5	0.68097283
60	WNK3	0.67533502
61	CDK6	0.67016463
62	MAP3K6	0.66657707
63	PDK2	0.66625152
64	CSNK1E	0.66471091
65	PRKCA	0.64239102
66	RET	0.63860221
67	MAP2K3	0.61805542
68	RPS6KA3	0.61103581
69	NEK1	0.58906689
70	CSF1R	0.58285917
71	MAP3K11	0.56505963
72	SGK1	0.55666078
73	PRKACB	0.55665922
74	STK16	0.55491484
75	MUSK	0.53774358
76	DAPK2	0.53013648
77	CAMK1D	0.52029629
78	GRK1	0.51010088
79	EPHB1	0.50902317
80	MAPKAPK3	0.49618781
81	TGFBR2	0.49392421
82	CAMKK1	0.49172150
83	GSK3A	0.48452531
84	SRC	0.46593380
85	SGK494	0.45205455
86	SGK223	0.45205455
87	TAOK2	0.43942294
88	PAK3	0.42279320
89	CSNK2A1	0.41572249
90	PRKCE	0.40541616
91	TIE1	0.40063451
92	KSR2	0.40016768
93	CAMK2G	0.39452492
94	BCR	0.39372094
95	DYRK1B	0.38483950
96	PDGFRA	0.38113873
97	PKN2	0.37390589
98	SGK3	0.36564580
99	CSNK2A2	0.36546176
100	MAPK4	0.36057521

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	4.12667571
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.07552218
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.05830225
4	Complement and coagulation cascades_Homo sapiens_hsa04610	3.96058184
5	* Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.66422380
6	* Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.39264819
7	* Retinol metabolism_Homo sapiens_hsa00830	3.37395564
8	* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.89836134
9	* Chemical carcinogenesis_Homo sapiens_hsa05204	2.88762259
10	* Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.86122587
11	* Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.77274004
12	* Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.69173591
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.66362180
14	Arginine biosynthesis_Homo sapiens_hsa00220	2.38840019
15	Phenylalanine metabolism_Homo sapiens_hsa00360	2.33870718
16	Fatty acid degradation_Homo sapiens_hsa00071	2.31524522
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.14398480
18	Butanoate metabolism_Homo sapiens_hsa00650	2.08394376
19	Tyrosine metabolism_Homo sapiens_hsa00350	2.07626685
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.86284816
21	* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.83767621
22	* Bile secretion_Homo sapiens_hsa04976	1.76646198
23	Histidine metabolism_Homo sapiens_hsa00340	1.75001883
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.74476921
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59175194
26	* Starch and sucrose metabolism_Homo sapiens_hsa00500	1.56311935
27	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.47239703
28	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.40130329
29	Peroxisome_Homo sapiens_hsa04146	1.38657671
30	PPAR signaling pathway_Homo sapiens_hsa03320	1.37998281
31	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.36019909
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.32941265
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.30705388
34	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.27352755
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.26986361
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22519587
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.20280490
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.13004861
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.08108998
40	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.05845135
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05513490
42	Prion diseases_Homo sapiens_hsa05020	1.01535088
43	Propanoate metabolism_Homo sapiens_hsa00640	0.95314029
44	Arginine and proline metabolism_Homo sapiens_hsa00330	0.94988360
45	Fatty acid metabolism_Homo sapiens_hsa01212	0.89001882
46	Carbon metabolism_Homo sapiens_hsa01200	0.86682546
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.85630100
48	ABC transporters_Homo sapiens_hsa02010	0.84269866
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.82707614
50	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.80110049
51	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.72752410
52	One carbon pool by folate_Homo sapiens_hsa00670	0.72030420
53	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.70011545
54	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.67067953
55	Sulfur metabolism_Homo sapiens_hsa00920	0.64196134
56	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.64038182
57	Lysine degradation_Homo sapiens_hsa00310	0.53002403
58	Sulfur relay system_Homo sapiens_hsa04122	0.47885319
59	* Metabolic pathways_Homo sapiens_hsa01100	0.42912351
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.32368798
61	Pertussis_Homo sapiens_hsa05133	0.31321112
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30176277
63	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.28565633
64	Fatty acid elongation_Homo sapiens_hsa00062	0.27444554
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.23218221
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.22206206
67	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.21785444
68	Pentose phosphate pathway_Homo sapiens_hsa00030	0.17935863
69	Insulin resistance_Homo sapiens_hsa04931	0.17658703
70	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.17574984
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.14629887
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.13104218
73	Glutathione metabolism_Homo sapiens_hsa00480	0.12076940
74	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.11818424
75	Galactose metabolism_Homo sapiens_hsa00052	0.09724448
76	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.07745283
77	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.06605770
78	Glucagon signaling pathway_Homo sapiens_hsa04922	0.06327527
79	Folate biosynthesis_Homo sapiens_hsa00790	0.04487043
80	Other glycan degradation_Homo sapiens_hsa00511	0.01229448
81	Serotonergic synapse_Homo sapiens_hsa04726	0.00149402
82	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.2625910
83	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.2569306
84	Ether lipid metabolism_Homo sapiens_hsa00565	-0.2392496
85	N-Glycan biosynthesis_Homo sapiens_hsa00510	-0.2256264
86	Circadian rhythm_Homo sapiens_hsa04710	-0.2122756
87	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	-0.1914939
88	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1904309
89	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.1813163
90	African trypanosomiasis_Homo sapiens_hsa05143	-0.1541597
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.1477826
92	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.1398153
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.1396885
94	Nitrogen metabolism_Homo sapiens_hsa00910	-0.1264879
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.1129698
96	Mineral absorption_Homo sapiens_hsa04978	-0.1115260
97	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.0900001
98	Amoebiasis_Homo sapiens_hsa05146	-0.0805251
99	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0499107
100	Renin-angiotensin system_Homo sapiens_hsa04614	-0.0157997

UGT2B4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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