

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | epoxygenase P450 pathway (GO:0019373) | 7.51254295 |
| 2 | L-phenylalanine catabolic process (GO:0006559) | 7.43672853 |
| 3 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 7.43672853 |
| 4 | L-phenylalanine metabolic process (GO:0006558) | 7.19115301 |
| 5 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 7.19115301 |
| 6 | aromatic amino acid family catabolic process (GO:0009074) | 7.12885207 |
| 7 | indole-containing compound catabolic process (GO:0042436) | 6.77537826 |
| 8 | indolalkylamine catabolic process (GO:0046218) | 6.77537826 |
| 9 | tryptophan catabolic process (GO:0006569) | 6.77537826 |
| 10 | omega-hydroxylase P450 pathway (GO:0097267) | 6.48578691 |
| 11 | kynurenine metabolic process (GO:0070189) | 6.48013736 |
| 12 | lysine metabolic process (GO:0006553) | 6.43314863 |
| 13 | lysine catabolic process (GO:0006554) | 6.43314863 |
| 14 | glyoxylate metabolic process (GO:0046487) | 6.38249998 |
| 15 | cysteine metabolic process (GO:0006534) | 6.38110078 |
| 16 | tryptophan metabolic process (GO:0006568) | 6.35312985 |
| 17 | fibrinolysis (GO:0042730) | 5.90257771 |
| 18 | bile acid biosynthetic process (GO:0006699) | 5.71115265 |
| 19 | blood coagulation, intrinsic pathway (GO:0007597) | 5.68143458 |
| 20 | oxidative demethylation (GO:0070989) | 5.57961346 |
| 21 | urate metabolic process (GO:0046415) | 5.49642916 |
| 22 | phenylpropanoid metabolic process (GO:0009698) | 5.46034606 |
| 23 | serine family amino acid catabolic process (GO:0009071) | 5.43876477 |
| 24 | drug transmembrane transport (GO:0006855) | 5.37635542 |
| 25 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 5.33093399 |
| 26 | sulfur amino acid catabolic process (GO:0000098) | 5.32854125 |
| 27 | homocysteine metabolic process (GO:0050667) | 5.27330410 |
| 28 | aromatic amino acid family metabolic process (GO:0009072) | 5.19917390 |
| 29 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 5.16382788 |
| 30 | alpha-linolenic acid metabolic process (GO:0036109) | 5.12065449 |
| 31 | amino-acid betaine metabolic process (GO:0006577) | 5.07523967 |
| 32 | cellular ketone body metabolic process (GO:0046950) | 5.00641548 |
| 33 | urea cycle (GO:0000050) | 4.97987319 |
| 34 | urea metabolic process (GO:0019627) | 4.97987319 |
| 35 | alpha-amino acid catabolic process (GO:1901606) | 4.83281028 |
| 36 | bile acid metabolic process (GO:0008206) | 4.82154788 |
| 37 | negative regulation of protein activation cascade (GO:2000258) | 4.80878631 |
| 38 | indolalkylamine metabolic process (GO:0006586) | 4.80562092 |
| 39 | hormone catabolic process (GO:0042447) | 4.73993900 |
| 40 | glutamate metabolic process (GO:0006536) | 4.71411179 |
| 41 | serine family amino acid metabolic process (GO:0009069) | 4.67492872 |
| 42 | amine catabolic process (GO:0009310) | 4.63596560 |
| 43 | cellular biogenic amine catabolic process (GO:0042402) | 4.63596560 |
| 44 | nitrogen cycle metabolic process (GO:0071941) | 4.62981728 |
| 45 | negative regulation of blood coagulation (GO:0030195) | 4.60363936 |
| 46 | negative regulation of hemostasis (GO:1900047) | 4.60363936 |
| 47 | tyrosine metabolic process (GO:0006570) | 4.56958076 |
| 48 | cellular amino acid catabolic process (GO:0009063) | 4.54935038 |
| 49 | flavonoid metabolic process (GO:0009812) | 4.54280508 |
| 50 | drug transport (GO:0015893) | 4.53544850 |
| 51 | short-chain fatty acid metabolic process (GO:0046459) | 4.53480935 |
| 52 | cellular modified amino acid catabolic process (GO:0042219) | 4.53221018 |
| 53 | aspartate family amino acid catabolic process (GO:0009068) | 4.53029109 |
| 54 | peptidyl-glutamic acid carboxylation (GO:0017187) | 4.53018390 |
| 55 | protein carboxylation (GO:0018214) | 4.53018390 |
| 56 | negative regulation of fibrinolysis (GO:0051918) | 4.51742190 |
| 57 | drug catabolic process (GO:0042737) | 4.48961146 |
| 58 | high-density lipoprotein particle remodeling (GO:0034375) | 4.47297648 |
| 59 | protein activation cascade (GO:0072376) | 4.42467729 |
| 60 | complement activation, alternative pathway (GO:0006957) | 4.41683282 |
| 61 | regulation of plasminogen activation (GO:0010755) | 4.41565272 |
| 62 | benzene-containing compound metabolic process (GO:0042537) | 4.41367352 |
| 63 | 2-oxoglutarate metabolic process (GO:0006103) | 4.34448536 |
| 64 | ketone body metabolic process (GO:1902224) | 4.33369760 |
| 65 | regulation of fibrinolysis (GO:0051917) | 4.32361604 |
| 66 | regulation of protein activation cascade (GO:2000257) | 4.31988771 |
| 67 | acetyl-CoA metabolic process (GO:0006084) | 4.30461793 |
| 68 | serine family amino acid biosynthetic process (GO:0009070) | 4.30022439 |
| 69 | negative regulation of wound healing (GO:0061045) | 4.22738791 |
| 70 | glycine metabolic process (GO:0006544) | 4.21628243 |
| 71 | negative regulation of cholesterol transport (GO:0032375) | 4.19204673 |
| 72 | negative regulation of sterol transport (GO:0032372) | 4.19204673 |
| 73 | coenzyme catabolic process (GO:0009109) | 4.18305377 |
| 74 | negative regulation of coagulation (GO:0050819) | 4.17820280 |
| 75 | heme transport (GO:0015886) | 4.17210485 |
| 76 | negative regulation of lipase activity (GO:0060192) | 4.15237390 |
| 77 | positive regulation of triglyceride lipase activity (GO:0061365) | 4.12111606 |
| 78 | positive regulation of lipoprotein lipase activity (GO:0051006) | 4.12111606 |
| 79 | alkaloid metabolic process (GO:0009820) | 4.07940853 |
| 80 | cellular glucuronidation (GO:0052695) | 4.06001110 |
| 81 | regulation of complement activation (GO:0030449) | 4.05695528 |
| 82 | acute-phase response (GO:0006953) | 4.05589909 |
| 83 | ethanol metabolic process (GO:0006067) | 4.04990691 |
| 84 | ethanol oxidation (GO:0006069) | 4.04303621 |
| 85 | regulation of humoral immune response (GO:0002920) | 4.04174814 |
| 86 | aldehyde catabolic process (GO:0046185) | 4.03458671 |
| 87 | organic acid catabolic process (GO:0016054) | 4.02687696 |
| 88 | carboxylic acid catabolic process (GO:0046395) | 4.02687696 |
| 89 | valine metabolic process (GO:0006573) | 4.02098609 |
| 90 | negative regulation of complement activation (GO:0045916) | 4.01472245 |
| 91 | regulation of triglyceride catabolic process (GO:0010896) | 4.01067355 |
| 92 | complement activation (GO:0006956) | 4.00115173 |
| 93 | dicarboxylic acid biosynthetic process (GO:0043650) | 4.00029887 |
| 94 | cholesterol efflux (GO:0033344) | 3.99648907 |
| 95 | acylglycerol homeostasis (GO:0055090) | 3.98979670 |
| 96 | triglyceride homeostasis (GO:0070328) | 3.98979670 |
| 97 | bile acid and bile salt transport (GO:0015721) | 3.98299514 |
| 98 | fatty acid beta-oxidation (GO:0006635) | 3.96849867 |
| 99 | exogenous drug catabolic process (GO:0042738) | 3.96498278 |
| 100 | regulation of lipoprotein particle clearance (GO:0010984) | 3.96385585 |
| 101 | S-adenosylmethionine metabolic process (GO:0046500) | 3.95624347 |
| 102 | carnitine metabolic process (GO:0009437) | 3.95238081 |
| 103 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 3.94079318 |
| 104 | fatty acid oxidation (GO:0019395) | 3.93754569 |
| 105 | response to mercury ion (GO:0046689) | 3.91205405 |
| 106 | regulation of cholesterol esterification (GO:0010872) | 3.90149534 |
| 107 | lipid oxidation (GO:0034440) | 3.86196308 |
| 108 | reverse cholesterol transport (GO:0043691) | 3.85259218 |
| 109 | plasma lipoprotein particle remodeling (GO:0034369) | 3.82384902 |
| 110 | protein-lipid complex remodeling (GO:0034368) | 3.82384902 |
| 111 | macromolecular complex remodeling (GO:0034367) | 3.82384902 |
| 112 | phosphate ion transmembrane transport (GO:0035435) | 3.80288288 |
| 113 | steroid catabolic process (GO:0006706) | 3.79844421 |
| 114 | monocarboxylic acid catabolic process (GO:0072329) | 3.76422666 |
| 115 | complement activation, classical pathway (GO:0006958) | 3.74425644 |
| 116 | uronic acid metabolic process (GO:0006063) | 3.73390897 |
| 117 | glucuronate metabolic process (GO:0019585) | 3.73390897 |
| 118 | arginine metabolic process (GO:0006525) | 3.70874573 |
| 119 | imidazole-containing compound metabolic process (GO:0052803) | 3.70463565 |
| 120 | fatty acid catabolic process (GO:0009062) | 3.69272147 |
| 121 | branched-chain amino acid metabolic process (GO:0009081) | 3.65583916 |
| 122 | regulation of cholesterol homeostasis (GO:2000188) | 3.62627067 |
| 123 | phospholipid efflux (GO:0033700) | 3.61824674 |
| 124 | xenobiotic metabolic process (GO:0006805) | 3.60918614 |
| 125 | xenobiotic catabolic process (GO:0042178) | 3.57548194 |
| 126 | branched-chain amino acid catabolic process (GO:0009083) | 3.56849241 |
| 127 | indole-containing compound metabolic process (GO:0042430) | 3.56148765 |
| 128 | plasma lipoprotein particle clearance (GO:0034381) | 3.55615554 |
| 129 | organic cation transport (GO:0015695) | 3.55210040 |
| 130 | positive regulation of hemostasis (GO:1900048) | 3.50847445 |
| 131 | positive regulation of blood coagulation (GO:0030194) | 3.50847445 |
| 132 | regulation of bile acid biosynthetic process (GO:0070857) | 3.49381230 |
| 133 | drug metabolic process (GO:0017144) | 3.48076847 |
| 134 | phosphate ion transport (GO:0006817) | 3.44277333 |
| 135 | small molecule catabolic process (GO:0044282) | 3.42352515 |
| 136 | pyridine nucleotide biosynthetic process (GO:0019363) | 3.40782387 |
| 137 | nicotinamide nucleotide biosynthetic process (GO:0019359) | 3.40782387 |
| 138 | intestinal cholesterol absorption (GO:0030299) | 3.40558300 |
| 139 | aminoglycoside antibiotic metabolic process (GO:0030647) | 3.39982380 |
| 140 | doxorubicin metabolic process (GO:0044598) | 3.39492142 |
| 141 | daunorubicin metabolic process (GO:0044597) | 3.39492142 |
| 142 | polyketide metabolic process (GO:0030638) | 3.39492142 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 8.21087783 |
| 2 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 7.01478026 |
| 3 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 6.48033470 |
| 4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 6.32565208 |
| 5 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.99113241 |
| 6 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 4.86094903 |
| 7 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 4.52393268 |
| 8 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.87989335 |
| 9 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 3.76284401 |
| 10 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.28021352 |
| 11 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.24887559 |
| 12 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 2.13178759 |
| 13 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 11.3781158 |
| 14 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.62658876 |
| 15 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.59834836 |
| 16 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.53521053 |
| 17 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.52074171 |
| 18 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.41745678 |
| 19 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.40776774 |
| 20 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.35805368 |
| 21 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.33011584 |
| 22 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.32829897 |
| 23 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.31125007 |
| 24 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.26659402 |
| 25 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.23164701 |
| 26 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.22577841 |
| 27 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.22456961 |
| 28 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.21165381 |
| 29 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.19184461 |
| 30 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.18696642 |
| 31 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.15682996 |
| 32 | GATA1_22025678_ChIP-Seq_K562_Human | 1.14739496 |
| 33 | NFYA_21822215_ChIP-Seq_K562_Human | 1.14362834 |
| 34 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.13370608 |
| 35 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.12785718 |
| 36 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.12696250 |
| 37 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.11325818 |
| 38 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.10495274 |
| 39 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.10455237 |
| 40 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.08820298 |
| 41 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.08535358 |
| 42 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.07555389 |
| 43 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 1.04237564 |
| 44 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.01902567 |
| 45 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.00024904 |
| 46 | NFYB_21822215_ChIP-Seq_K562_Human | 0.99257742 |
| 47 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.97883285 |
| 48 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.97759076 |
| 49 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.96836026 |
| 50 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.95201937 |
| 51 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.95201937 |
| 52 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.94021151 |
| 53 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.92867500 |
| 54 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.91520430 |
| 55 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 0.91230980 |
| 56 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.90249348 |
| 57 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.89518562 |
| 58 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.87948839 |
| 59 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.87180910 |
| 60 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.86680408 |
| 61 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.86271768 |
| 62 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.85033873 |
| 63 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.84560474 |
| 64 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.83958517 |
| 65 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.83052323 |
| 66 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.82238671 |
| 67 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.81806576 |
| 68 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.81806576 |
| 69 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.81725777 |
| 70 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.81329198 |
| 71 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.81122870 |
| 72 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.80972530 |
| 73 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.80856065 |
| 74 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.80136761 |
| 75 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.79886359 |
| 76 | ESRRB_18555785_Chip-Seq_ESCs_Mouse | 0.79844994 |
| 77 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.79248670 |
| 78 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.79056104 |
| 79 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.78531316 |
| 80 | * GBX2_23144817_ChIP-Seq_PC3_Human | 0.78032757 |
| 81 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.77899546 |
| 82 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.77744038 |
| 83 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.77653926 |
| 84 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.77377945 |
| 85 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.77123711 |
| 86 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.76227494 |
| 87 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 0.76103310 |
| 88 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.75320644 |
| 89 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.75188687 |
| 90 | ZFX_18555785_Chip-Seq_ESCs_Mouse | 0.75032376 |
| 91 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.74440980 |
| 92 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.73846411 |
| 93 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.73737878 |
| 94 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.73459224 |
| 95 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.72984795 |
| 96 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.72481075 |
| 97 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.71380486 |
| 98 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.70948676 |
| 99 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.70762083 |
| 100 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.70762083 |
| 101 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.70312772 |
| 102 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.69943670 |
| 103 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.69933354 |
| 104 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.69710991 |
| 105 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.69710991 |
| 106 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.68372941 |
| 107 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.68117937 |
| 108 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.65818858 |
| 109 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.65671075 |
| 110 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.64738415 |
| 111 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.64617457 |
| 112 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.64583305 |
| 113 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.63411821 |
| 114 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.61338352 |
| 115 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.59717356 |
| 116 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.59654414 |
| 117 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.59582790 |
| 118 | AR_20517297_ChIP-Seq_VCAP_Human | 0.59496041 |
| 119 | STAT1_17558387_ChIP-Seq_HELA_Human | 0.58612109 |
| 120 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.57879954 |
| 121 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.55882882 |
| 122 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.55513910 |
| 123 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.54862476 |
| 124 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.53557312 |
| 125 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.52707074 |
| 126 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.51779824 |
| 127 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.51712102 |
| 128 | CBP_21632823_ChIP-Seq_H3396_Human | 0.51600109 |
| 129 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.50549999 |
| 130 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.48828300 |
| 131 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.48534995 |
| 132 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.48300940 |
| 133 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.48009147 |
| 134 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.46891758 |
| 135 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.46219185 |
| 136 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.45757654 |
| 137 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.45477295 |
| 138 | GATA2_19941826_ChIP-Seq_K562_Human | 0.45202997 |
| 139 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.45084987 |
| 140 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.44959876 |
| 141 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.44447203 |
| 142 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.44235199 |
| 143 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.43880197 |
| 144 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.43753414 |
| 145 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.43316003 |
| 146 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.42970191 |
| 147 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.42807320 |
| 148 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.42467319 |
| 149 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.42095053 |
| 150 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.41942534 |
| 151 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.41788977 |
| 152 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.41577900 |
| 153 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.41213680 |
| 154 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.41133002 |
| 155 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.41084834 |
| 156 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.40603317 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005360_urolithiasis | 8.38629748 |
| 2 | MP0002139_abnormal_hepatobiliary_system | 7.99380602 |
| 3 | MP0005085_abnormal_gallbladder_physiolo | 5.81053586 |
| 4 | MP0005365_abnormal_bile_salt | 5.68935565 |
| 5 | MP0008875_abnormal_xenobiotic_pharmacok | 4.89213516 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 3.87552457 |
| 7 | MP0003252_abnormal_bile_duct | 3.80637011 |
| 8 | MP0005332_abnormal_amino_acid | 3.62758786 |
| 9 | MP0003195_calcinosis | 3.60298563 |
| 10 | MP0010329_abnormal_lipoprotein_level | 3.08413376 |
| 11 | MP0004019_abnormal_vitamin_homeostasis | 3.03914460 |
| 12 | MP0002138_abnormal_hepatobiliary_system | 2.61271201 |
| 13 | MP0009840_abnormal_foam_cell | 2.54750788 |
| 14 | MP0001666_abnormal_nutrient_absorption | 2.44621708 |
| 15 | MP0005083_abnormal_biliary_tract | 2.42731864 |
| 16 | MP0003191_abnormal_cellular_cholesterol | 2.11715063 |
| 17 | MP0009643_abnormal_urine_homeostasis | 2.07152278 |
| 18 | MP0002118_abnormal_lipid_homeostasis | 1.93510588 |
| 19 | MP0004043_abnormal_pH_regulation | 1.90438596 |
| 20 | MP0000609_abnormal_liver_physiology | 1.88902515 |
| 21 | MP0005319_abnormal_enzyme/_coenzyme | 1.83563048 |
| 22 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.69564910 |
| 23 | MP0001764_abnormal_homeostasis | 1.69358537 |
| 24 | MP0003868_abnormal_feces_composition | 1.62344524 |
| 25 | MP0005451_abnormal_body_composition | 1.60363591 |
| 26 | MP0005636_abnormal_mineral_homeostasis | 1.57617413 |
| 27 | MP0003186_abnormal_redox_activity | 1.46461847 |
| 28 | MP0001756_abnormal_urination | 1.40621293 |
| 29 | MP0003879_abnormal_hair_cell | 1.32285270 |
| 30 | MP0002136_abnormal_kidney_physiology | 1.16071652 |
| 31 | MP0002876_abnormal_thyroid_physiology | 1.13974307 |
| 32 | MP0001765_abnormal_ion_homeostasis | 1.12549578 |
| 33 | MP0005187_abnormal_penis_morphology | 1.10324803 |
| 34 | MP0002132_abnormal_respiratory_system | 1.09553255 |
| 35 | MP0009697_abnormal_copulation | 1.06092320 |
| 36 | MP0000598_abnormal_liver_morphology | 1.05358164 |
| 37 | MP0009764_decreased_sensitivity_to | 1.02704338 |
| 38 | MP0006036_abnormal_mitochondrial_physio | 1.00362473 |
| 39 | MP0005647_abnormal_sex_gland | 0.98071561 |
| 40 | MP0005084_abnormal_gallbladder_morpholo | 0.95127844 |
| 41 | MP0003646_muscle_fatigue | 0.94247823 |
| 42 | MP0003656_abnormal_erythrocyte_physiolo | 0.92091762 |
| 43 | MP0003011_delayed_dark_adaptation | 0.90271397 |
| 44 | MP0009642_abnormal_blood_homeostasis | 0.89494008 |
| 45 | MP0005670_abnormal_white_adipose | 0.87522899 |
| 46 | MP0000604_amyloidosis | 0.86829246 |
| 47 | MP0005535_abnormal_body_temperature | 0.86587521 |
| 48 | MP0008469_abnormal_protein_level | 0.84874881 |
| 49 | MP0003705_abnormal_hypodermis_morpholog | 0.83516632 |
| 50 | MP0004272_abnormal_basement_membrane | 0.82541611 |
| 51 | MP0001661_extended_life_span | 0.81791388 |
| 52 | MP0010386_abnormal_urinary_bladder | 0.79586601 |
| 53 | MP0009763_increased_sensitivity_to | 0.78955102 |
| 54 | MP0005408_hypopigmentation | 0.77916464 |
| 55 | MP0003941_abnormal_skin_development | 0.77098379 |
| 56 | MP0002078_abnormal_glucose_homeostasis | 0.75286634 |
| 57 | MP0004145_abnormal_muscle_electrophysio | 0.75236861 |
| 58 | MP0001915_intracranial_hemorrhage | 0.74211215 |
| 59 | MP0005220_abnormal_exocrine_pancreas | 0.73572241 |
| 60 | MP0002928_abnormal_bile_duct | 0.72177019 |
| 61 | MP0005376_homeostasis/metabolism_phenot | 0.70329922 |
| 62 | MP0005410_abnormal_fertilization | 0.68562294 |
| 63 | MP0009765_abnormal_xenobiotic_induced | 0.67821682 |
| 64 | MP0005058_abnormal_lysosome_morphology | 0.66929822 |
| 65 | MP0000538_abnormal_urinary_bladder | 0.63734554 |
| 66 | MP0006035_abnormal_mitochondrial_morpho | 0.62839633 |
| 67 | MP0002254_reproductive_system_inflammat | 0.62016441 |
| 68 | MP0000230_abnormal_systemic_arterial | 0.61089917 |
| 69 | MP0003638_abnormal_response/metabolism_ | 0.60847086 |
| 70 | MP0002971_abnormal_brown_adipose | 0.59525889 |
| 71 | MP0010368_abnormal_lymphatic_system | 0.59067639 |
| 72 | MP0005395_other_phenotype | 0.58397940 |
| 73 | MP0002168_other_aberrant_phenotype | 0.58074357 |
| 74 | MP0003329_amyloid_beta_deposits | 0.58056677 |
| 75 | MP0005334_abnormal_fat_pad | 0.57752720 |
| 76 | MP0002249_abnormal_larynx_morphology | 0.54165469 |
| 77 | MP0005266_abnormal_metabolism | 0.53169477 |
| 78 | MP0003690_abnormal_glial_cell | 0.52989455 |
| 79 | MP0008961_abnormal_basal_metabolism | 0.52646086 |
| 80 | MP0004130_abnormal_muscle_cell | 0.51183487 |
| 81 | MP0005666_abnormal_adipose_tissue | 0.49935732 |
| 82 | MP0002282_abnormal_trachea_morphology | 0.48947871 |
| 83 | MP0002135_abnormal_kidney_morphology | 0.47126557 |
| 84 | MP0009053_abnormal_anal_canal | 0.46754691 |
| 85 | MP0002090_abnormal_vision | 0.46045035 |
| 86 | MP0003953_abnormal_hormone_level | 0.44408094 |
| 87 | MP0002269_muscular_atrophy | 0.43945975 |
| 88 | MP0002796_impaired_skin_barrier | 0.43484795 |
| 89 | MP0002697_abnormal_eye_size | 0.42106921 |
| 90 | MP0003724_increased_susceptibility_to | 0.41135284 |
| 91 | MP0003950_abnormal_plasma_membrane | 0.39423723 |
| 92 | MP0008874_decreased_physiological_sensi | 0.39151224 |
| 93 | MP0003718_maternal_effect | 0.38760734 |
| 94 | MP0003300_gastrointestinal_ulcer | 0.38431920 |
| 95 | MP0004264_abnormal_extraembryonic_tissu | 0.37370184 |
| 96 | MP0003959_abnormal_lean_body | 0.37227967 |
| 97 | MP0004036_abnormal_muscle_relaxation | 0.37211775 |
| 98 | MP0005166_decreased_susceptibility_to | 0.35690546 |
| 99 | MP0005448_abnormal_energy_balance | 0.35414534 |
| 100 | MP0009672_abnormal_birth_weight | 0.34678983 |
| 101 | MP0003075_altered_response_to | 0.34576164 |
| 102 | MP0008873_increased_physiological_sensi | 0.32998074 |
| 103 | MP0000639_abnormal_adrenal_gland | 0.32749266 |
| 104 | MP0006292_abnormal_olfactory_placode | 0.32522845 |
| 105 | MP0004782_abnormal_surfactant_physiolog | 0.32381633 |
| 106 | MP0005023_abnormal_wound_healing | 0.31807223 |
| 107 | MP0008872_abnormal_physiological_respon | 0.31010729 |
| 108 | MP0006082_CNS_inflammation | 0.30241473 |
| 109 | MP0002837_dystrophic_cardiac_calcinosis | 0.30152834 |
| 110 | MP0003878_abnormal_ear_physiology | 0.30121549 |
| 111 | MP0005377_hearing/vestibular/ear_phenot | 0.30121549 |
| 112 | MP0002332_abnormal_exercise_endurance | 0.29630777 |
| 113 | MP0004147_increased_porphyrin_level | 0.29584722 |
| 114 | MP0010234_abnormal_vibrissa_follicle | 0.29321591 |
| 115 | MP0001845_abnormal_inflammatory_respons | 0.28413289 |
| 116 | MP0002089_abnormal_postnatal_growth/wei | 0.28053429 |
| 117 | MP0005464_abnormal_platelet_physiology | 0.26452379 |
| 118 | MP0000749_muscle_degeneration | 0.26227013 |
| 119 | MP0002822_catalepsy | 0.25429715 |
| 120 | MP0009115_abnormal_fat_cell | 0.25407164 |
| 121 | MP0000751_myopathy | 0.23779283 |
| 122 | MP0005551_abnormal_eye_electrophysiolog | 0.23196476 |
| 123 | MP0003436_decreased_susceptibility_to | 0.22914844 |
| 124 | MP0000747_muscle_weakness | 0.22748388 |
| 125 | MP0002069_abnormal_eating/drinking_beha | 0.22342059 |
| 126 | MP0005167_abnormal_blood-brain_barrier | 0.21305498 |
| 127 | MP0003890_abnormal_embryonic-extraembry | 0.20688090 |
| 128 | MP0004142_abnormal_muscle_tone | 0.20235981 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 6.52202343 |
| 2 | Intrahepatic cholestasis (HP:0001406) | 6.09468609 |
| 3 | Deep venous thrombosis (HP:0002625) | 5.71481972 |
| 4 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 5.46336272 |
| 5 | Xanthomatosis (HP:0000991) | 5.32226614 |
| 6 | Hyperglycinuria (HP:0003108) | 5.15582099 |
| 7 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 5.06536713 |
| 8 | Glomerulonephritis (HP:0000099) | 4.88600100 |
| 9 | Hypobetalipoproteinemia (HP:0003563) | 4.86704231 |
| 10 | Prolonged partial thromboplastin time (HP:0003645) | 4.85680503 |
| 11 | Abnormality of glycine metabolism (HP:0010895) | 4.78964484 |
| 12 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.78964484 |
| 13 | Ketosis (HP:0001946) | 4.71266749 |
| 14 | Hyperglycinemia (HP:0002154) | 4.68798456 |
| 15 | Gout (HP:0001997) | 4.67612479 |
| 16 | Hyperammonemia (HP:0001987) | 4.52300419 |
| 17 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.43739866 |
| 18 | Hyperlipoproteinemia (HP:0010980) | 4.29765065 |
| 19 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.27860716 |
| 20 | Complement deficiency (HP:0004431) | 4.07625124 |
| 21 | Ketoacidosis (HP:0001993) | 4.06766541 |
| 22 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.98292936 |
| 23 | Joint hemorrhage (HP:0005261) | 3.93177269 |
| 24 | Abnormality of purine metabolism (HP:0004352) | 3.89583662 |
| 25 | Osteomalacia (HP:0002749) | 3.79723629 |
| 26 | Reduced antithrombin III activity (HP:0001976) | 3.70107707 |
| 27 | Delayed CNS myelination (HP:0002188) | 3.70029158 |
| 28 | Abnormality of nucleobase metabolism (HP:0010932) | 3.67450423 |
| 29 | Hypolipoproteinemia (HP:0010981) | 3.58936517 |
| 30 | Fat malabsorption (HP:0002630) | 3.56139812 |
| 31 | Hypoglycemic coma (HP:0001325) | 3.54487728 |
| 32 | Abnormality of methionine metabolism (HP:0010901) | 3.51299475 |
| 33 | Hyperuricemia (HP:0002149) | 3.48860050 |
| 34 | Increased purine levels (HP:0004368) | 3.48860050 |
| 35 | Epidermoid cyst (HP:0200040) | 3.48388638 |
| 36 | Proximal tubulopathy (HP:0000114) | 3.43970224 |
| 37 | Nephritis (HP:0000123) | 3.35415761 |
| 38 | Alkalosis (HP:0001948) | 3.32208642 |
| 39 | Abnormality of the common coagulation pathway (HP:0010990) | 3.31909501 |
| 40 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 3.28078071 |
| 41 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.23183945 |
| 42 | Metabolic acidosis (HP:0001942) | 3.16376128 |
| 43 | Hypoalphalipoproteinemia (HP:0003233) | 3.10071569 |
| 44 | Abnormality of serum amino acid levels (HP:0003112) | 3.09886280 |
| 45 | Hypokalemic alkalosis (HP:0001949) | 3.09385311 |
| 46 | Conjugated hyperbilirubinemia (HP:0002908) | 3.04119179 |
| 47 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.03824196 |
| 48 | Dicarboxylic aciduria (HP:0003215) | 3.03824196 |
| 49 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.03521676 |
| 50 | Generalized aminoaciduria (HP:0002909) | 3.02016206 |
| 51 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.01555607 |
| 52 | Vascular calcification (HP:0004934) | 2.96937874 |
| 53 | Hyperactive renin-angiotensin system (HP:0000841) | 2.96196804 |
| 54 | Increased circulating renin level (HP:0000848) | 2.95687959 |
| 55 | Abnormality of complement system (HP:0005339) | 2.88785909 |
| 56 | Hyperbilirubinemia (HP:0002904) | 2.88763657 |
| 57 | Abnormality of the intrinsic pathway (HP:0010989) | 2.86561273 |
| 58 | Metabolic alkalosis (HP:0200114) | 2.85799836 |
| 59 | Lethargy (HP:0001254) | 2.85558725 |
| 60 | Hepatocellular carcinoma (HP:0001402) | 2.78549464 |
| 61 | Steatorrhea (HP:0002570) | 2.74952703 |
| 62 | Hypomagnesemia (HP:0002917) | 2.73344226 |
| 63 | Hypercholesterolemia (HP:0003124) | 2.70217156 |
| 64 | Gingival bleeding (HP:0000225) | 2.69644698 |
| 65 | Cholecystitis (HP:0001082) | 2.68148909 |
| 66 | Abnormal gallbladder physiology (HP:0012438) | 2.68148909 |
| 67 | Malnutrition (HP:0004395) | 2.64184960 |
| 68 | Cardiovascular calcification (HP:0011915) | 2.62735030 |
| 69 | Abnormal urine output (HP:0012590) | 2.60767913 |
| 70 | Abnormality of urine glucose concentration (HP:0011016) | 2.57936389 |
| 71 | Glycosuria (HP:0003076) | 2.57936389 |
| 72 | Vomiting (HP:0002013) | 2.55907307 |
| 73 | Enlarged kidneys (HP:0000105) | 2.55585696 |
| 74 | Abnormality of proline metabolism (HP:0010907) | 2.51895810 |
| 75 | Hydroxyprolinuria (HP:0003080) | 2.51895810 |
| 76 | Polyuria (HP:0000103) | 2.48843960 |
| 77 | Neonatal onset (HP:0003623) | 2.47801763 |
| 78 | Abnormality of chloride homeostasis (HP:0011422) | 2.46691725 |
| 79 | Irritability (HP:0000737) | 2.45912910 |
| 80 | Rickets (HP:0002748) | 2.41373389 |
| 81 | Spastic diplegia (HP:0001264) | 2.41176077 |
| 82 | Cerebral edema (HP:0002181) | 2.41090177 |
| 83 | Retinal atrophy (HP:0001105) | 2.35589089 |
| 84 | Abnormality of renal excretion (HP:0011036) | 2.34256528 |
| 85 | Abnormality of the Achilles tendon (HP:0005109) | 2.33574379 |
| 86 | Myocardial infarction (HP:0001658) | 2.26565150 |
| 87 | Abnormal urine phosphate concentration (HP:0012599) | 2.24985932 |
| 88 | Systemic lupus erythematosus (HP:0002725) | 2.24808265 |
| 89 | Abnormality of magnesium homeostasis (HP:0004921) | 2.24754511 |
| 90 | Sensorimotor neuropathy (HP:0007141) | 2.24295191 |
| 91 | Distal arthrogryposis (HP:0005684) | 2.23457586 |
| 92 | Late onset (HP:0003584) | 2.18153832 |
| 93 | Nephrolithiasis (HP:0000787) | 2.15946089 |
| 94 | Fair hair (HP:0002286) | 2.13886358 |
| 95 | Elevated alkaline phosphatase (HP:0003155) | 2.13675818 |
| 96 | Facial shape deformation (HP:0011334) | 2.12959337 |
| 97 | Potter facies (HP:0002009) | 2.12959337 |
| 98 | Mitral stenosis (HP:0001718) | 2.12641669 |
| 99 | Abnormal enzyme/coenzyme activity (HP:0012379) | 2.12120082 |
| 100 | Hypochromic microcytic anemia (HP:0004840) | 2.11448021 |
| 101 | Pancreatitis (HP:0001733) | 2.09887841 |
| 102 | Skin nodule (HP:0200036) | 2.08952771 |
| 103 | Menorrhagia (HP:0000132) | 2.08884751 |
| 104 | Renal tubular acidosis (HP:0001947) | 2.08201223 |
| 105 | Confusion (HP:0001289) | 2.06438290 |
| 106 | Hypoglycemic seizures (HP:0002173) | 2.06233931 |
| 107 | Arthropathy (HP:0003040) | 2.04585770 |
| 108 | Spontaneous abortion (HP:0005268) | 2.04497600 |
| 109 | Cholelithiasis (HP:0001081) | 2.02834678 |
| 110 | Bile duct proliferation (HP:0001408) | 2.02100565 |
| 111 | Abnormal biliary tract physiology (HP:0012439) | 2.02100565 |
| 112 | Thrombophlebitis (HP:0004418) | 2.00423212 |
| 113 | Hypophosphatemic rickets (HP:0004912) | 1.99427541 |
| 114 | Hyperphosphaturia (HP:0003109) | 1.98227258 |
| 115 | Opisthotonus (HP:0002179) | 1.95100324 |
| 116 | Tetany (HP:0001281) | 1.95054878 |
| 117 | Nausea (HP:0002018) | 1.90826369 |
| 118 | Polydipsia (HP:0001959) | 1.90643134 |
| 119 | Abnormal drinking behavior (HP:0030082) | 1.90643134 |
| 120 | Abnormality of alkaline phosphatase activity (HP:0004379) | 1.90299379 |
| 121 | Abnormality of vitamin metabolism (HP:0100508) | 1.89068300 |
| 122 | Abnormal gallbladder morphology (HP:0012437) | 1.86511980 |
| 123 | Abnormal delivery (HP:0001787) | 1.86368708 |
| 124 | Renal salt wasting (HP:0000127) | 1.86223308 |
| 125 | Nemaline bodies (HP:0003798) | 1.81826311 |
| 126 | Hemorrhage of the eye (HP:0011885) | 1.80760329 |
| 127 | Pulmonary embolism (HP:0002204) | 1.78410787 |
| 128 | Increased serum ferritin (HP:0003281) | 1.75236187 |
| 129 | Muscle fiber inclusion bodies (HP:0100299) | 1.73498169 |
| 130 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.69121624 |
| 131 | Neonatal hypoglycemia (HP:0001998) | 1.67654448 |
| 132 | Atrioventricular block (HP:0001678) | 1.66183094 |
| 133 | Cerebral palsy (HP:0100021) | 1.65922909 |
| 134 | Abnormality of iron homeostasis (HP:0011031) | 1.65893775 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BCKDK | 6.67826806 |
| 2 | WNK3 | 5.79648602 |
| 3 | OBSCN | 5.03438055 |
| 4 | OXSR1 | 4.21061638 |
| 5 | WNK4 | 4.12114589 |
| 6 | FGFR4 | 3.76988707 |
| 7 | SIK1 | 3.19095838 |
| 8 | ERN1 | 3.15881168 |
| 9 | INSRR | 2.36288844 |
| 10 | MUSK | 2.23234983 |
| 11 | MST1R | 2.13545836 |
| 12 | STK38L | 2.09716264 |
| 13 | ERBB4 | 2.06085292 |
| 14 | TAOK3 | 1.94888703 |
| 15 | ACVR1B | 1.79395908 |
| 16 | MAP2K4 | 1.68637440 |
| 17 | PBK | 1.64499936 |
| 18 | MAPK11 | 1.51896993 |
| 19 | STK39 | 1.48694266 |
| 20 | PINK1 | 1.47092281 |
| 21 | PKN2 | 1.43764862 |
| 22 | SGK494 | 1.38889987 |
| 23 | SGK223 | 1.38889987 |
| 24 | PDK4 | 1.36830445 |
| 25 | PDK3 | 1.36830445 |
| 26 | NLK | 1.36715208 |
| 27 | PIK3CA | 1.33685453 |
| 28 | PIK3CG | 1.32241881 |
| 29 | PLK4 | 1.29523375 |
| 30 | ABL2 | 1.25562388 |
| 31 | CASK | 1.25429821 |
| 32 | LATS1 | 1.24381955 |
| 33 | TRIB3 | 1.22931301 |
| 34 | MAP3K7 | 1.17490576 |
| 35 | AKT3 | 1.17132942 |
| 36 | FLT3 | 1.14901586 |
| 37 | SGK3 | 1.14259775 |
| 38 | PTK6 | 1.13417780 |
| 39 | SGK2 | 1.12432357 |
| 40 | GRK6 | 1.09160649 |
| 41 | TYK2 | 1.08111275 |
| 42 | PHKG1 | 1.07538361 |
| 43 | PHKG2 | 1.07538361 |
| 44 | PRKG1 | 1.05669330 |
| 45 | TIE1 | 1.03249035 |
| 46 | NEK1 | 1.02667281 |
| 47 | FRK | 1.02182566 |
| 48 | DAPK2 | 0.99528195 |
| 49 | PRKAA2 | 0.99047052 |
| 50 | PDK2 | 0.98643407 |
| 51 | MYLK | 0.98022798 |
| 52 | MAP3K14 | 0.97823348 |
| 53 | NEK9 | 0.96359471 |
| 54 | JAK2 | 0.96008147 |
| 55 | FGFR2 | 0.90847627 |
| 56 | MAP3K12 | 0.88323272 |
| 57 | TNIK | 0.87580914 |
| 58 | MAP2K3 | 0.85133501 |
| 59 | MAP3K3 | 0.83972887 |
| 60 | PRKCZ | 0.83670992 |
| 61 | GSK3A | 0.82615300 |
| 62 | PRKAA1 | 0.80592405 |
| 63 | KDR | 0.80112422 |
| 64 | EPHB1 | 0.78865353 |
| 65 | BMPR1B | 0.75638736 |
| 66 | PRKACB | 0.75148541 |
| 67 | MET | 0.74324461 |
| 68 | CSNK1D | 0.73976945 |
| 69 | MAPK15 | 0.72261648 |
| 70 | FER | 0.71802943 |
| 71 | DYRK1B | 0.70603898 |
| 72 | NTRK3 | 0.70556084 |
| 73 | STK38 | 0.69142728 |
| 74 | IRAK3 | 0.68982328 |
| 75 | MAPK4 | 0.65843362 |
| 76 | MAP3K9 | 0.65224407 |
| 77 | TGFBR2 | 0.64902145 |
| 78 | TTN | 0.64281398 |
| 79 | NEK6 | 0.64105494 |
| 80 | NUAK1 | 0.63876948 |
| 81 | PRKACG | 0.63639232 |
| 82 | PTK2 | 0.62972728 |
| 83 | TBK1 | 0.62439381 |
| 84 | ZAK | 0.62122876 |
| 85 | PDPK1 | 0.61966107 |
| 86 | MAPK12 | 0.61899425 |
| 87 | PRKCE | 0.61729989 |
| 88 | PRKCB | 0.61206291 |
| 89 | ERBB2 | 0.61108816 |
| 90 | JAK1 | 0.60381499 |
| 91 | MAP3K11 | 0.56989098 |
| 92 | MAP3K10 | 0.56015692 |
| 93 | MAP2K6 | 0.55983169 |
| 94 | RPS6KA3 | 0.55748615 |
| 95 | CDK4 | 0.55038540 |
| 96 | TNK2 | 0.52293523 |
| 97 | MAPKAPK3 | 0.51332891 |
| 98 | CSNK1A1 | 0.51165936 |
| 99 | AKT2 | 0.51091089 |
| 100 | DAPK3 | 0.50084437 |
| 101 | CSK | 0.48181944 |
| 102 | MELK | 0.47119229 |
| 103 | RIPK1 | 0.43546216 |
| 104 | STK3 | 0.43370245 |
| 105 | CDK6 | 0.42836868 |
| 106 | CAMK2G | 0.42318038 |
| 107 | IRAK2 | 0.41173619 |
| 108 | PDK1 | 0.41046325 |
| 109 | EPHA4 | 0.39587634 |
| 110 | PKN1 | 0.39490578 |
| 111 | PRKCQ | 0.38676852 |
| 112 | CSNK2A1 | 0.37716321 |
| 113 | CSNK1E | 0.37636833 |
| 114 | FGFR1 | 0.37501324 |
| 115 | MAP4K2 | 0.36420940 |
| 116 | STK16 | 0.35784275 |
| 117 | ARAF | 0.35664407 |
| 118 | WNK1 | 0.34427981 |
| 119 | MAP2K2 | 0.34253619 |
| 120 | IGF1R | 0.34046434 |
| 121 | MAPK7 | 0.32332080 |
| 122 | CSNK2A2 | 0.32206600 |
| 123 | CSNK1G1 | 0.30025483 |
| 124 | LRRK2 | 0.29810197 |
| 125 | GRK1 | 0.28406695 |
| 126 | IRAK1 | 0.28354930 |
| 127 | MAP3K13 | 0.28217630 |
| 128 | PRKCG | 0.27755309 |
| 129 | FGFR3 | 0.27311216 |
| 130 | PAK3 | 0.26803815 |
| 131 | CAMK1D | 0.26585543 |
| 132 | SGK1 | 0.26351737 |
| 133 | CSF1R | 0.25718683 |
| 134 | PRKCA | 0.25508718 |
| 135 | CAMK4 | 0.24886906 |
| 136 | IKBKE | 0.23776324 |
| 137 | MAP3K6 | 0.23715833 |
| 138 | MAP3K5 | 0.23679581 |
| 139 | MTOR | 0.21153642 |
| 140 | TAOK2 | 0.20823877 |
| 141 | EPHA3 | 0.20699882 |
| 142 | MAP2K1 | 0.20648447 |
| 143 | PRKCD | 0.19144073 |
| 144 | EGFR | 0.19129489 |
| 145 | PRKACA | 0.17379497 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.99044913 |
| 2 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.40798662 |
| 3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.04933655 |
| 4 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.03902019 |
| 5 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.96370543 |
| 6 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.80108095 |
| 7 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.79430691 |
| 8 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.76948818 |
| 9 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.70251039 |
| 10 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.61504490 |
| 11 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.59588653 |
| 12 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.51210519 |
| 13 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.43319430 |
| 14 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.37425863 |
| 15 | Peroxisome_Homo sapiens_hsa04146 | 2.35091911 |
| 16 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.30100217 |
| 17 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.14231691 |
| 18 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.11493197 |
| 19 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.91448863 |
| 20 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.90708799 |
| 21 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.90103082 |
| 22 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.84058020 |
| 23 | Histidine metabolism_Homo sapiens_hsa00340 | 1.76827186 |
| 24 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.71532450 |
| 25 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.71064115 |
| 26 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.71025385 |
| 27 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.69378462 |
| 28 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.68738526 |
| 29 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.65554394 |
| 30 | Bile secretion_Homo sapiens_hsa04976 | 1.65306609 |
| 31 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.59259505 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.56401112 |
| 33 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.55334337 |
| 34 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.51214698 |
| 35 | Retinol metabolism_Homo sapiens_hsa00830 | 1.49987919 |
| 36 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.44778828 |
| 37 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.41938852 |
| 38 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.38564272 |
| 39 | Carbon metabolism_Homo sapiens_hsa01200 | 1.31762409 |
| 40 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.30635490 |
| 41 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.26852602 |
| 42 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.25871973 |
| 43 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.25804012 |
| 44 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.25661497 |
| 45 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.25408104 |
| 46 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.25392569 |
| 47 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.24163907 |
| 48 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.17884349 |
| 49 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.16068381 |
| 50 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.09221077 |
| 51 | Lysine degradation_Homo sapiens_hsa00310 | 1.02976889 |
| 52 | ABC transporters_Homo sapiens_hsa02010 | 1.01877020 |
| 53 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.95570274 |
| 54 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.92216869 |
| 55 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.92205025 |
| 56 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.91090739 |
| 57 | Sulfur relay system_Homo sapiens_hsa04122 | 0.86786935 |
| 58 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.84801577 |
| 59 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.81119010 |
| 60 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.79677534 |
| 61 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.79134036 |
| 62 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.75714851 |
| 63 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.72841016 |
| 64 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.60775905 |
| 65 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.57639231 |
| 66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.51356550 |
| 67 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.40313878 |
| 68 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.29766939 |
| 69 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.23728141 |
| 70 | Galactose metabolism_Homo sapiens_hsa00052 | 0.20977478 |
| 71 | Insulin resistance_Homo sapiens_hsa04931 | 0.18928175 |
| 72 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.18310962 |
| 73 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.16532269 |
| 74 | Prion diseases_Homo sapiens_hsa05020 | 0.15664543 |
| 75 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.15292232 |
| 76 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.08644254 |
| 77 | Pertussis_Homo sapiens_hsa05133 | 0.06318660 |
| 78 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.05934670 |
| 79 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.04844916 |
| 80 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.04788485 |
| 81 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.03853712 |
| 82 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.03811309 |
| 83 | Mineral absorption_Homo sapiens_hsa04978 | 0.00016464 |
| 84 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | -0.1840960 |
| 85 | ECM-receptor interaction_Homo sapiens_hsa04512 | -0.1811059 |
| 86 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | -0.1806801 |
| 87 | Oxidative phosphorylation_Homo sapiens_hsa00190 | -0.1793342 |
| 88 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.1714898 |
| 89 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.1684758 |
| 90 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | -0.1670971 |
| 91 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.1537891 |
| 92 | Hepatitis C_Homo sapiens_hsa05160 | -0.1502626 |
| 93 | Circadian rhythm_Homo sapiens_hsa04710 | -0.1467516 |
| 94 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | -0.1435728 |
| 95 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | -0.1397801 |
| 96 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.1357066 |
| 97 | Ether lipid metabolism_Homo sapiens_hsa00565 | -0.1334581 |
| 98 | Amoebiasis_Homo sapiens_hsa05146 | -0.1230232 |
| 99 | Regulation of autophagy_Homo sapiens_hsa04140 | -0.1210954 |
| 100 | Lysosome_Homo sapiens_hsa04142 | -0.0837149 |
| 101 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | -0.0777211 |
| 102 | Collecting duct acid secretion_Homo sapiens_hsa04966 | -0.0719290 |
| 103 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | -0.0510944 |
| 104 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.0484394 |
| 105 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | -0.0459633 |
| 106 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | -0.0126802 |
| 107 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | -0.0102046 |
| 108 | AMPK signaling pathway_Homo sapiens_hsa04152 | -0.0068314 |
| 109 | Other glycan degradation_Homo sapiens_hsa00511 | -0.0062674 |
| 110 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.0017308 |
| 111 | Serotonergic synapse_Homo sapiens_hsa04726 | -0.0010124 |

