UGT3A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.42893788
2L-phenylalanine catabolic process (GO:0006559)7.42893788
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.19346364
4L-phenylalanine metabolic process (GO:0006558)7.19346364
5aromatic amino acid family catabolic process (GO:0009074)6.95742973
6glyoxylate metabolic process (GO:0046487)6.67561228
7lysine catabolic process (GO:0006554)6.59298509
8lysine metabolic process (GO:0006553)6.59298509
9tryptophan catabolic process (GO:0006569)6.47575610
10indole-containing compound catabolic process (GO:0042436)6.47575610
11indolalkylamine catabolic process (GO:0046218)6.47575610
12cysteine metabolic process (GO:0006534)6.41382799
13urate metabolic process (GO:0046415)6.25053440
14drug transmembrane transport (GO:0006855)6.14760912
15tryptophan metabolic process (GO:0006568)6.10307742
16kynurenine metabolic process (GO:0070189)5.99466950
17homocysteine metabolic process (GO:0050667)5.54881175
18bile acid biosynthetic process (GO:0006699)5.52355470
19serine family amino acid catabolic process (GO:0009071)5.49436037
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.44567762
21sulfur amino acid catabolic process (GO:0000098)5.24275409
22drug catabolic process (GO:0042737)5.18454253
23drug transport (GO:0015893)5.14310924
24establishment of integrated proviral latency (GO:0075713)5.12697080
25amino-acid betaine metabolic process (GO:0006577)5.07995889
26aromatic amino acid family metabolic process (GO:0009072)5.07978155
27urea metabolic process (GO:0019627)4.85933988
28urea cycle (GO:0000050)4.85933988
29alpha-linolenic acid metabolic process (GO:0036109)4.84657577
30exogenous drug catabolic process (GO:0042738)4.83079996
31alpha-amino acid catabolic process (GO:1901606)4.81825317
32chromatin remodeling at centromere (GO:0031055)4.81198878
33serine family amino acid metabolic process (GO:0009069)4.78420112
34cellular ketone body metabolic process (GO:0046950)4.78146180
35CENP-A containing nucleosome assembly (GO:0034080)4.70368807
36short-chain fatty acid metabolic process (GO:0046459)4.69384508
37cellular modified amino acid catabolic process (GO:0042219)4.69200033
38aspartate family amino acid catabolic process (GO:0009068)4.65289294
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.59967536
40glutamate metabolic process (GO:0006536)4.59919499
41bile acid metabolic process (GO:0008206)4.59421336
42indolalkylamine metabolic process (GO:0006586)4.58507573
43cellular amino acid catabolic process (GO:0009063)4.56511463
44nitrogen cycle metabolic process (GO:0071941)4.52770778
45tyrosine metabolic process (GO:0006570)4.46383641
46L-serine metabolic process (GO:0006563)4.43544034
47cellular biogenic amine catabolic process (GO:0042402)4.40521668
48amine catabolic process (GO:0009310)4.40521668
49DNA replication checkpoint (GO:0000076)4.38170293
50IMP biosynthetic process (GO:0006188)4.36705973
51DNA strand elongation involved in DNA replication (GO:0006271)4.36495007
52acetyl-CoA metabolic process (GO:0006084)4.35217833
53benzene-containing compound metabolic process (GO:0042537)4.32890774
54serine family amino acid biosynthetic process (GO:0009070)4.32716940
552-oxoglutarate metabolic process (GO:0006103)4.30030758
56response to mercury ion (GO:0046689)4.28937442
57complement activation, alternative pathway (GO:0006957)4.24272138
58peptidyl-glutamic acid carboxylation (GO:0017187)4.22797782
59protein carboxylation (GO:0018214)4.22797782
60negative regulation of fibrinolysis (GO:0051918)4.19943072
61DNA strand elongation (GO:0022616)4.19280497
62glycine metabolic process (GO:0006544)4.15089483
63ketone body metabolic process (GO:1902224)4.13510571
64protein localization to kinetochore (GO:0034501)4.11688280
65aldehyde catabolic process (GO:0046185)4.08044208
66valine metabolic process (GO:0006573)4.07866360
67cellular glucuronidation (GO:0052695)4.07711315
68regulation of protein activation cascade (GO:2000257)4.06962971
69mitotic metaphase plate congression (GO:0007080)4.06788773
70coenzyme catabolic process (GO:0009109)4.06312843
71organic cation transport (GO:0015695)4.05875884
72fatty acid beta-oxidation (GO:0006635)4.05848291
73organic acid catabolic process (GO:0016054)4.04646582
74carboxylic acid catabolic process (GO:0046395)4.04646582
75phosphate ion transport (GO:0006817)4.03939368
76DNA replication-independent nucleosome assembly (GO:0006336)4.03395110
77DNA replication-independent nucleosome organization (GO:0034724)4.03395110
78high-density lipoprotein particle remodeling (GO:0034375)4.03236068
79histone exchange (GO:0043486)4.01886139
80dicarboxylic acid biosynthetic process (GO:0043650)4.01568561
81regulation of fibrinolysis (GO:0051917)3.99871471
82fatty acid oxidation (GO:0019395)3.98249026
83carnitine metabolic process (GO:0009437)3.97528454
84ethanol oxidation (GO:0006069)3.95239629
85lipid oxidation (GO:0034440)3.90647748
86purine nucleobase biosynthetic process (GO:0009113)3.90283744
87negative regulation of sterol transport (GO:0032372)3.88285279
88negative regulation of cholesterol transport (GO:0032375)3.88285279
89telomere maintenance via semi-conservative replication (GO:0032201)3.86535693
90IMP metabolic process (GO:0046040)3.85481414
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.84073662
92regulation of mitotic spindle checkpoint (GO:1903504)3.84073662
93phosphate ion transmembrane transport (GO:0035435)3.83466151
94glucuronate metabolic process (GO:0019585)3.83112918
95uronic acid metabolic process (GO:0006063)3.83112918
96regulation of complement activation (GO:0030449)3.82547190
97branched-chain amino acid metabolic process (GO:0009081)3.81993927
98pre-miRNA processing (GO:0031054)3.81853342
99monocarboxylic acid catabolic process (GO:0072329)3.79646378
100establishment of viral latency (GO:0019043)3.78574458
101fatty acid catabolic process (GO:0009062)3.74832725
102regulation of triglyceride catabolic process (GO:0010896)3.73341387
103nucleobase biosynthetic process (GO:0046112)3.71705795
104bile acid and bile salt transport (GO:0015721)3.70750034
105drug metabolic process (GO:0017144)3.70086078
106triglyceride homeostasis (GO:0070328)3.69978238
107acylglycerol homeostasis (GO:0055090)3.69978238
108regulation of helicase activity (GO:0051095)3.66609420
109branched-chain amino acid catabolic process (GO:0009083)3.63548732
110quaternary ammonium group transport (GO:0015697)3.62494084
111arginine metabolic process (GO:0006525)3.62237243
112regulation of cholesterol homeostasis (GO:2000188)3.61850550
113tricarboxylic acid metabolic process (GO:0072350)3.61521637
114DNA replication-dependent nucleosome assembly (GO:0006335)3.60347234
115DNA replication-dependent nucleosome organization (GO:0034723)3.60347234
116DNA ligation (GO:0006266)3.58576684
117DNA unwinding involved in DNA replication (GO:0006268)3.55608761
118indole-containing compound metabolic process (GO:0042430)3.54929079
119flavonoid metabolic process (GO:0009812)3.53768129
120negative regulation of chromosome segregation (GO:0051985)3.51987150
121regulation of bile acid biosynthetic process (GO:0070857)3.51923340
122chaperone-mediated protein transport (GO:0072321)3.51382745
123regulation of cholesterol esterification (GO:0010872)3.50968176
124fructose metabolic process (GO:0006000)3.50623444
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.49813733
126negative regulation of mitotic sister chromatid segregation (GO:0033048)3.49813733
127negative regulation of mitotic sister chromatid separation (GO:2000816)3.49813733
128negative regulation of sister chromatid segregation (GO:0033046)3.49813733
129negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.49813733
130protein-lipid complex remodeling (GO:0034368)3.47784194
131macromolecular complex remodeling (GO:0034367)3.47784194
132plasma lipoprotein particle remodeling (GO:0034369)3.47784194
133reverse cholesterol transport (GO:0043691)3.46401224
134heterochromatin organization (GO:0070828)3.43506589
135negative regulation of DNA-dependent DNA replication (GO:2000104)3.43292307
136regulation of posttranscriptional gene silencing (GO:0060147)3.43012534
137regulation of gene silencing by miRNA (GO:0060964)3.43012534
138regulation of gene silencing by RNA (GO:0060966)3.43012534
139metaphase plate congression (GO:0051310)3.41216825
140protein localization to chromosome, centromeric region (GO:0071459)3.40473177
141regulation of nuclear cell cycle DNA replication (GO:0033262)3.39709564
142negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.33662017
143telomere maintenance via recombination (GO:0000722)3.33458931
144mitotic recombination (GO:0006312)3.32082523
145negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31322969
146ribosome assembly (GO:0042255)3.29088346
147protein complex localization (GO:0031503)3.24626925
148mitotic sister chromatid cohesion (GO:0007064)3.23873240
149DNA replication initiation (GO:0006270)3.22947683
150double-strand break repair via nonhomologous end joining (GO:0006303)3.22553410
151non-recombinational repair (GO:0000726)3.22553410
152ATP-dependent chromatin remodeling (GO:0043044)3.22491559
153nuclear pore complex assembly (GO:0051292)3.21933861
154anterior/posterior axis specification, embryo (GO:0008595)3.17332177
155spindle checkpoint (GO:0031577)3.17253057
156mitotic spindle checkpoint (GO:0071174)3.17202963
157regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17136745
158regulation of mitotic metaphase/anaphase transition (GO:0030071)3.17136745
159negative regulation of mRNA processing (GO:0050686)3.16810965
160regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14615392
161negative regulation of RNA splicing (GO:0033119)3.14419518
162proteasome assembly (GO:0043248)3.13739299
163adrenergic receptor signaling pathway (GO:0071875)3.10910551
164DNA damage response, detection of DNA damage (GO:0042769)3.10231237
165regulation of sister chromatid segregation (GO:0033045)3.09811969
166regulation of mitotic sister chromatid separation (GO:0010965)3.09811969
167regulation of mitotic sister chromatid segregation (GO:0033047)3.09811969
168mitotic spindle assembly checkpoint (GO:0007094)3.08977866
169response to X-ray (GO:0010165)3.07349097
170mitotic sister chromatid segregation (GO:0000070)3.07104747
171establishment of protein localization to mitochondrial membrane (GO:0090151)3.06622805
172mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06074514
173spliceosomal snRNP assembly (GO:0000387)3.04223368
174negative regulation of ligase activity (GO:0051352)3.03819074
175negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03819074
176chromatin assembly or disassembly (GO:0006333)3.03502382
177spindle assembly checkpoint (GO:0071173)3.02265251
178formation of translation preinitiation complex (GO:0001731)3.02134194
179regulation of chromosome segregation (GO:0051983)3.00899675
180DNA topological change (GO:0006265)2.99497726
181telomere maintenance via telomere lengthening (GO:0010833)2.97837593
182nuclear pore organization (GO:0006999)2.97221668
183regulation of spindle checkpoint (GO:0090231)2.96055826
184kinetochore organization (GO:0051383)2.95463533
185mitotic nuclear envelope disassembly (GO:0007077)2.94618980
186anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94197341
187folic acid-containing compound biosynthetic process (GO:0009396)2.93982436
188DNA double-strand break processing (GO:0000729)2.93029800
189termination of RNA polymerase II transcription (GO:0006369)2.92928132
190negative regulation of mitosis (GO:0045839)2.91852726
191regulation of translational fidelity (GO:0006450)2.90472889
192sister chromatid segregation (GO:0000819)2.89221354
193transcription elongation from RNA polymerase III promoter (GO:0006385)2.89040128
194termination of RNA polymerase III transcription (GO:0006386)2.89040128
195negative regulation of mRNA metabolic process (GO:1903312)2.87349138
196regulation of centriole replication (GO:0046599)2.87229680
197mitotic G2/M transition checkpoint (GO:0044818)2.85340649
198kinetochore assembly (GO:0051382)2.83987711
199regulation of histone H3-K9 methylation (GO:0051570)2.82442037
200maturation of SSU-rRNA (GO:0030490)2.79938786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.48108194
2RXR_22158963_ChIP-Seq_LIVER_Mouse8.14218088
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.91401843
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.25693633
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.14406445
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.96006813
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.77050941
8MYC_18555785_ChIP-Seq_MESCs_Mouse4.48529471
9* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.23733348
10E2F4_17652178_ChIP-ChIP_JURKAT_Human4.12059510
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97880321
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.80913703
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.60117721
14* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.50239903
15MYC_19079543_ChIP-ChIP_MESCs_Mouse3.22022055
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19653200
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05267183
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.01524118
19MYC_19030024_ChIP-ChIP_MESCs_Mouse3.00996593
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93732174
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.87681187
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78605834
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.75902252
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65209872
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59597381
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.52850707
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.52850707
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.52850707
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42492617
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38233902
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.37209349
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35187932
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32659575
34ETS1_20019798_ChIP-Seq_JURKAT_Human2.27200852
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26023865
36E2F1_21310950_ChIP-Seq_MCF-7_Human2.22214946
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.19737480
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.10187033
39E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09743500
40THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07131262
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05576457
42MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02920952
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00136593
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2803829
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.99069625
46XRN2_22483619_ChIP-Seq_HELA_Human1.97307528
47FOXP3_21729870_ChIP-Seq_TREG_Human1.94788272
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.93075877
49ELK1_19687146_ChIP-ChIP_HELA_Human1.90909999
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90386446
51NANOG_16153702_ChIP-ChIP_HESCs_Human1.88493372
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83912659
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.81822857
54TTF2_22483619_ChIP-Seq_HELA_Human1.79506130
55CLOCK_20551151_ChIP-Seq_293T_Human1.78776602
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74587852
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70836606
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.69271304
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.68834599
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.65860089
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.65090268
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63987417
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63723864
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.63496243
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62137370
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59145096
67VDR_23849224_ChIP-Seq_CD4+_Human1.58957735
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58599105
69HNF4A_19822575_ChIP-Seq_HepG2_Human1.56070626
70DCP1A_22483619_ChIP-Seq_HELA_Human1.54081134
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53541766
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50264423
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49557519
74GABP_19822575_ChIP-Seq_HepG2_Human1.44550027
75NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.43423688
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41033761
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.37481860
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36651742
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.36265004
80MYC_18940864_ChIP-ChIP_HL60_Human1.35313258
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32886068
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32115304
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.31872124
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29156225
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28643645
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28207147
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28080840
88NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23524144
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18964846
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17664908
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15620385
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15042117
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14049332
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11375672
95GATA1_22025678_ChIP-Seq_K562_Human1.11117174
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09429127
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.08953549
98TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08610064
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.07605249
100RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06329436
101HTT_18923047_ChIP-ChIP_STHdh_Human1.05985431
102GATA4_25053715_ChIP-Seq_YYC3_Human1.05480766
103KDM5A_27292631_Chip-Seq_BREAST_Human1.04463647
104SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04172434
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04109446
106SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98441107
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98166112
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.97797084
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96356561
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94788251
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91976030
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91682383
113CDX2_20551321_ChIP-Seq_CACO-2_Human0.91043399
114EWS_26573619_Chip-Seq_HEK293_Human0.90557207
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90451773
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.89740239
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86421450
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86190530
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85528906
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85267386
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84066062
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83487780
123OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83321099
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82677694
125EGR1_19032775_ChIP-ChIP_M12_Human0.82069374
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81821502
127ELF1_17652178_ChIP-ChIP_JURKAT_Human0.80813248
128TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80521079
129AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79705697
130IRF8_22096565_ChIP-ChIP_GC-B_Human0.78554392
131Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78309305
132GATA1_26923725_Chip-Seq_HPCs_Mouse0.77720498
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.76228293
134TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76015298
135STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75164946
136ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75125042
137LXR_22292898_ChIP-Seq_THP-1_Human0.74715034
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74575872
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74334913
140SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72990493
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71262323
142NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71262323
143POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.71084629
144NANOG_18692474_ChIP-Seq_MEFs_Mouse0.70844973
145CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70169235
146BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69992203
147RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69526274
148* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69025644
149FOXO3_23340844_ChIP-Seq_DLD1_Human0.67141988
150GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.66988314
151NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66364402
152AR_21909140_ChIP-Seq_LNCAP_Human0.66196590
153FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.64204930
154ZNF263_19887448_ChIP-Seq_K562_Human0.63569568
155TRIM28_21343339_ChIP-Seq_HEK293_Human0.63180874
156MYC_19915707_ChIP-ChIP_AK7_Human0.62945110
157SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62714984
158ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.62562643
159GATA6_25053715_ChIP-Seq_YYC3_Human0.62519774
160FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62414137
161CEBPB_22108803_ChIP-Seq_LS180_Human0.62347165
162ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61729900
163CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.61489846
164RARA_24833708_ChIP-Seq_LIVER_Mouse0.59936070
165AR_20517297_ChIP-Seq_VCAP_Human0.59886603
166ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57642787
167PPAR_26484153_Chip-Seq_NCI-H1993_Human0.56097056
168ESET_19884257_ChIP-Seq_ESCs_Mouse0.55854203
169CBP_21632823_ChIP-Seq_H3396_Human0.53920766
170STAT1_17558387_ChIP-Seq_HELA_Human0.53811756
171FOXA1_25552417_ChIP-Seq_VCAP_Human0.51731185
172EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.51723619
173TAF2_19829295_ChIP-Seq_ESCs_Human0.51638859
174CDX2_22108803_ChIP-Seq_LS180_Human0.51369311
175SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49758342
176FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.49681963
177RACK7_27058665_Chip-Seq_MCF-7_Human0.49555612
178SOX2_20726797_ChIP-Seq_SW620_Human0.49365116
179PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49354557
180ERG_21242973_ChIP-ChIP_JURKAT_Human0.48719087
181STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.48151373
182RARB_24833708_ChIP-Seq_LIVER_Mouse0.48138461
183GATA2_19941826_ChIP-Seq_K562_Human0.47366196
184FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.47093229
185GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.46896479
186P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.46683147
187ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.46287314
188PIAS1_25552417_ChIP-Seq_VCAP_Human0.46270732
189GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.46109273
190PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46092255
191PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45769203
192TBX20_22080862_ChIP-Seq_HEART_Mouse0.44475316
193TBX20_22328084_ChIP-Seq_HEART_Mouse0.44475316
194SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.43703528
195FOXH1_21741376_ChIP-Seq_EPCs_Human0.42387326
196GATA1_19941826_ChIP-Seq_K562_Human0.41976603
197CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.41882212

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.41532266
2MP0002139_abnormal_hepatobiliary_system7.78815910
3MP0005085_abnormal_gallbladder_physiolo5.61062764
4MP0005365_abnormal_bile_salt5.45552769
5MP0008875_abnormal_xenobiotic_pharmacok4.89229446
6MP0003693_abnormal_embryo_hatching4.09518563
7MP0004957_abnormal_blastocyst_morpholog3.87372546
8MP0005332_abnormal_amino_acid3.83624145
9MP0010094_abnormal_chromosome_stability3.82835909
10MP0003252_abnormal_bile_duct3.82764411
11MP0003111_abnormal_nucleus_morphology3.64788500
12MP0003195_calcinosis3.59578112
13MP0003806_abnormal_nucleotide_metabolis3.56960978
14MP0003890_abnormal_embryonic-extraembry3.51639113
15MP0003941_abnormal_skin_development3.40037114
16MP0004019_abnormal_vitamin_homeostasis3.37083730
17MP0008057_abnormal_DNA_replication3.09953441
18MP0008058_abnormal_DNA_repair3.08704669
19MP0008877_abnormal_DNA_methylation2.92406170
20MP0002138_abnormal_hepatobiliary_system2.90313908
21MP0008932_abnormal_embryonic_tissue2.88172882
22MP0010329_abnormal_lipoprotein_level2.85032471
23MP0003077_abnormal_cell_cycle2.80205781
24MP0004043_abnormal_pH_regulation2.40357613
25MP0009643_abnormal_urine_homeostasis2.32786336
26MP0005083_abnormal_biliary_tract2.28369549
27MP0001666_abnormal_nutrient_absorption2.27536500
28MP0009840_abnormal_foam_cell2.24577549
29MP0008007_abnormal_cellular_replicative2.17759896
30MP0001730_embryonic_growth_arrest2.11504459
31MP0001293_anophthalmia2.02701562
32MP0002102_abnormal_ear_morphology1.99659862
33MP0003191_abnormal_cellular_cholesterol1.98480274
34MP0005499_abnormal_olfactory_system1.94438245
35MP0005394_taste/olfaction_phenotype1.94438245
36MP0006292_abnormal_olfactory_placode1.92263141
37MP0003567_abnormal_fetal_cardiomyocyte1.89691889
38MP0002118_abnormal_lipid_homeostasis1.85869721
39MP0005319_abnormal_enzyme/_coenzyme1.84167282
40MP0009780_abnormal_chondrocyte_physiolo1.83301208
41MP0000609_abnormal_liver_physiology1.81226131
42MP0000350_abnormal_cell_proliferation1.80303376
43MP0001188_hyperpigmentation1.79732134
44MP0005636_abnormal_mineral_homeostasis1.79583583
45MP0005584_abnormal_enzyme/coenzyme_acti1.73407044
46MP0003937_abnormal_limbs/digits/tail_de1.67856295
47MP0010030_abnormal_orbit_morphology1.66849584
48MP0001764_abnormal_homeostasis1.63720465
49MP0001286_abnormal_eye_development1.63171059
50MP0002085_abnormal_embryonic_tissue1.62904826
51MP0005380_embryogenesis_phenotype1.62524353
52MP0001672_abnormal_embryogenesis/_devel1.62524353
53MP0003186_abnormal_redox_activity1.58634611
54MP0001756_abnormal_urination1.58301604
55MP0002084_abnormal_developmental_patter1.58082035
56MP0000049_abnormal_middle_ear1.57436084
57MP0005451_abnormal_body_composition1.55251360
58MP0009379_abnormal_foot_pigmentation1.54027266
59MP0003119_abnormal_digestive_system1.51799177
60MP0009703_decreased_birth_body1.51039529
61MP0004133_heterotaxia1.49549813
62MP0002163_abnormal_gland_morphology1.46794693
63MP0001765_abnormal_ion_homeostasis1.46444738
64MP0003868_abnormal_feces_composition1.45743981
65MP0001697_abnormal_embryo_size1.41194420
66MP0002111_abnormal_tail_morphology1.40841728
67MP0002136_abnormal_kidney_physiology1.39140125
68MP0004197_abnormal_fetal_growth/weight/1.38745013
69MP0002653_abnormal_ependyma_morphology1.34930715
70MP0002233_abnormal_nose_morphology1.34798432
71MP0003984_embryonic_growth_retardation1.33389688
72MP0002088_abnormal_embryonic_growth/wei1.29330675
73MP0002080_prenatal_lethality1.28920183
74MP0002277_abnormal_respiratory_mucosa1.27226006
75MP0002697_abnormal_eye_size1.24767094
76MP0000428_abnormal_craniofacial_morphol1.17830597
77MP0000579_abnormal_nail_morphology1.14173870
78MP0003121_genomic_imprinting1.12042395
79MP0002938_white_spotting1.10781250
80MP0010307_abnormal_tumor_latency1.10190516
81MP0001485_abnormal_pinna_reflex1.09256482
82MP0002932_abnormal_joint_morphology1.08870299
83MP0002876_abnormal_thyroid_physiology1.07183063
84MP0005670_abnormal_white_adipose1.06385713
85MP0005084_abnormal_gallbladder_morpholo1.05697928
86MP0006036_abnormal_mitochondrial_physio1.05386841
87MP0000598_abnormal_liver_morphology1.04854281
88MP0009764_decreased_sensitivity_to1.02702193
89MP0002751_abnormal_autonomic_nervous1.02374111
90MP0005076_abnormal_cell_differentiation1.02084920
91MP0000313_abnormal_cell_death1.00622763
92MP0002396_abnormal_hematopoietic_system0.98876037
93MP0003786_premature_aging0.93637630
94MP0002086_abnormal_extraembryonic_tissu0.90587045
95MP0009642_abnormal_blood_homeostasis0.90208104
96MP0003861_abnormal_nervous_system0.89169677
97MP0005535_abnormal_body_temperature0.88745436
98MP0005058_abnormal_lysosome_morphology0.88735788
99MP0005379_endocrine/exocrine_gland_phen0.88281571
100MP0003123_paternal_imprinting0.86889531
101MP0003136_yellow_coat_color0.85374226
102MP0010352_gastrointestinal_tract_polyps0.85013011
103MP0008469_abnormal_protein_level0.84395441
104MP0003011_delayed_dark_adaptation0.84310432
105MP0005647_abnormal_sex_gland0.84202708
106MP0004185_abnormal_adipocyte_glucose0.83823406
107MP0003705_abnormal_hypodermis_morpholog0.83547060
108MP0002928_abnormal_bile_duct0.82072855
109MP0001145_abnormal_male_reproductive0.81654799
110MP0008789_abnormal_olfactory_epithelium0.81077751
111MP0001177_atelectasis0.80580123
112MP0000604_amyloidosis0.80437722
113MP0003656_abnormal_erythrocyte_physiolo0.80347513
114MP0003755_abnormal_palate_morphology0.80142944
115MP0001661_extended_life_span0.79820016
116MP0009697_abnormal_copulation0.79400154
117MP0000432_abnormal_head_morphology0.79193901
118MP0005408_hypopigmentation0.79105003
119MP0005220_abnormal_exocrine_pancreas0.78443234
120MP0001486_abnormal_startle_reflex0.77401239
121MP0004142_abnormal_muscle_tone0.76566581
122MP0005501_abnormal_skin_physiology0.75995466
123MP0009763_increased_sensitivity_to0.75468719
124MP0002210_abnormal_sex_determination0.74855331
125MP0003122_maternal_imprinting0.74526962
126MP0002116_abnormal_craniofacial_bone0.74433230
127MP0003787_abnormal_imprinting0.74295098
128MP0002078_abnormal_glucose_homeostasis0.72808642
129MP0003385_abnormal_body_wall0.72753507
130MP0000538_abnormal_urinary_bladder0.72678526
131MP0000762_abnormal_tongue_morphology0.72539843
132MP0001929_abnormal_gametogenesis0.72051958
133MP0001727_abnormal_embryo_implantation0.71542075
134MP0001299_abnormal_eye_distance/0.70380020
135MP0002114_abnormal_axial_skeleton0.70356564
136MP0000653_abnormal_sex_gland0.70192288
137MP0000647_abnormal_sebaceous_gland0.68858684
138MP0000230_abnormal_systemic_arterial0.67559207
139MP0005376_homeostasis/metabolism_phenot0.67145781
140MP0002168_other_aberrant_phenotype0.66459018
141MP0009765_abnormal_xenobiotic_induced0.65895872
142MP0009250_abnormal_appendicular_skeleto0.65580893
143MP0000358_abnormal_cell_content/0.64986984
144MP0008961_abnormal_basal_metabolism0.63991736
145MP0001881_abnormal_mammary_gland0.63610057
146MP0003638_abnormal_response/metabolism_0.63540437
147MP0005666_abnormal_adipose_tissue0.61426294
148MP0006035_abnormal_mitochondrial_morpho0.60403120
149MP0002971_abnormal_brown_adipose0.60059505
150MP0003329_amyloid_beta_deposits0.59316957
151MP0005395_other_phenotype0.58489484
152MP0003300_gastrointestinal_ulcer0.56770690
153MP0005377_hearing/vestibular/ear_phenot0.56396423
154MP0003878_abnormal_ear_physiology0.56396423
155MP0002135_abnormal_kidney_morphology0.55163197
156MP0002254_reproductive_system_inflammat0.53356178
157MP0005334_abnormal_fat_pad0.52339905
158MP0001958_emphysema0.51471976
159MP0005266_abnormal_metabolism0.51334042
160MP0003690_abnormal_glial_cell0.50166620
161MP0004130_abnormal_muscle_cell0.50142174
162MP0002796_impaired_skin_barrier0.45962475
163MP0010368_abnormal_lymphatic_system0.45473515
164MP0003953_abnormal_hormone_level0.44546453
165MP0004264_abnormal_extraembryonic_tissu0.43725133
166MP0009053_abnormal_anal_canal0.42786057
167MP0003724_increased_susceptibility_to0.41928521
168MP0004885_abnormal_endolymph0.39951314
169MP0004147_increased_porphyrin_level0.39315381
170MP0009672_abnormal_birth_weight0.38032581
171MP0003959_abnormal_lean_body0.36946290
172MP0008874_decreased_physiological_sensi0.36916123
173MP0010234_abnormal_vibrissa_follicle0.36426353
174MP0005166_decreased_susceptibility_to0.35514659
175MP0003075_altered_response_to0.35406420
176MP0008873_increased_physiological_sensi0.33588552
177MP0008872_abnormal_physiological_respon0.33167855
178MP0005448_abnormal_energy_balance0.29383846
179MP0002837_dystrophic_cardiac_calcinosis0.28542954
180MP0001845_abnormal_inflammatory_respons0.28432529
181MP0002896_abnormal_bone_mineralization0.28298014
182MP0003718_maternal_effect0.28249205
183MP0009384_cardiac_valve_regurgitation0.27471940
184MP0000639_abnormal_adrenal_gland0.25761504
185MP0004782_abnormal_surfactant_physiolog0.25722548
186MP0009115_abnormal_fat_cell0.24467589
187MP0005167_abnormal_blood-brain_barrier0.23709962

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.16910107
2Intrahepatic cholestasis (HP:0001406)5.64722724
3Abnormality of glutamine family amino acid metabolism (HP:0010902)5.29720858
4Gout (HP:0001997)5.19659225
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.14537984
6Hyperglycinuria (HP:0003108)5.12591137
7Deep venous thrombosis (HP:0002625)5.08615759
8Xanthomatosis (HP:0000991)5.03480163
9Abnormality of serine family amino acid metabolism (HP:0010894)4.68753043
10Abnormality of glycine metabolism (HP:0010895)4.68753043
11Ketosis (HP:0001946)4.62368111
12Hyperglycinemia (HP:0002154)4.42919748
13Hyperammonemia (HP:0001987)4.40093448
14Abnormality of aspartate family amino acid metabolism (HP:0010899)4.39447150
15Colon cancer (HP:0003003)4.34816147
16Prolonged partial thromboplastin time (HP:0003645)4.26851073
17Hypobetalipoproteinemia (HP:0003563)4.25292285
18Abnormality of purine metabolism (HP:0004352)4.10509877
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.09453241
20Ketoacidosis (HP:0001993)4.02929288
21Abnormality of the labia minora (HP:0012880)4.01668600
22Proximal tubulopathy (HP:0000114)3.88455489
23Bilateral microphthalmos (HP:0007633)3.85989441
24Abnormality of fatty-acid metabolism (HP:0004359)3.80727351
25Hypokalemic alkalosis (HP:0001949)3.80346642
26Abnormality of nucleobase metabolism (HP:0010932)3.78822754
27Hyperlipoproteinemia (HP:0010980)3.78462920
28Increased circulating renin level (HP:0000848)3.77954393
29Hyperuricemia (HP:0002149)3.75833716
30Increased purine levels (HP:0004368)3.75833716
31Alkalosis (HP:0001948)3.72382559
32Complement deficiency (HP:0004431)3.65732360
33Metabolic alkalosis (HP:0200114)3.53169063
34Delayed CNS myelination (HP:0002188)3.53080891
35Hyperactive renin-angiotensin system (HP:0000841)3.52537813
36Birth length less than 3rd percentile (HP:0003561)3.49768264
37Joint hemorrhage (HP:0005261)3.48809101
38Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47034438
39Chromsome breakage (HP:0040012)3.39926732
40Generalized aminoaciduria (HP:0002909)3.39882491
41Epidermoid cyst (HP:0200040)3.32262531
42Hypoglycemic coma (HP:0001325)3.31675353
43Hypomagnesemia (HP:0002917)3.28552222
44Abnormality of methionine metabolism (HP:0010901)3.27470524
45Fat malabsorption (HP:0002630)3.23148008
46Multiple enchondromatosis (HP:0005701)3.21892083
47Abnormal urine output (HP:0012590)3.19564346
48Hypolipoproteinemia (HP:0010981)3.16476791
49Polyuria (HP:0000103)3.16343873
50Abnormality of pyrimidine metabolism (HP:0004353)3.15448508
51Reticulocytopenia (HP:0001896)3.11988150
52Rhabdomyosarcoma (HP:0002859)3.08157556
53Metabolic acidosis (HP:0001942)3.07722006
54Abnormality of chloride homeostasis (HP:0011422)3.06004355
55Septo-optic dysplasia (HP:0100842)3.03793832
56Vascular calcification (HP:0004934)3.03284260
57Abnormality of the common coagulation pathway (HP:0010990)3.01794600
58Abnormality of serum amino acid levels (HP:0003112)3.00838393
59Dicarboxylic aciduria (HP:0003215)2.96771879
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.96771879
61Abnormal lung lobation (HP:0002101)2.95283231
62Abnormality of renal excretion (HP:0011036)2.95095999
63Nephroblastoma (Wilms tumor) (HP:0002667)2.92828031
64Abnormality of urine glucose concentration (HP:0011016)2.91374956
65Glycosuria (HP:0003076)2.91374956
66Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.89605113
67Meckel diverticulum (HP:0002245)2.87007258
68Embryonal renal neoplasm (HP:0011794)2.85657224
69Lethargy (HP:0001254)2.83883778
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.82349235
71Conjugated hyperbilirubinemia (HP:0002908)2.81649142
72Hypoalphalipoproteinemia (HP:0003233)2.76680828
73Hydroxyprolinuria (HP:0003080)2.74834746
74Abnormality of proline metabolism (HP:0010907)2.74834746
75Short middle phalanx of the 5th finger (HP:0004220)2.73587118
76Abnormality of magnesium homeostasis (HP:0004921)2.71918101
77Hyperbilirubinemia (HP:0002904)2.71868251
78Hepatocellular carcinoma (HP:0001402)2.71665210
79Cardiovascular calcification (HP:0011915)2.69074245
80Aplasia/Hypoplasia of the uvula (HP:0010293)2.68695196
81Abnormality of the ileum (HP:0001549)2.67990682
82Selective tooth agenesis (HP:0001592)2.62197380
83Cortical dysplasia (HP:0002539)2.61254280
84Enlarged kidneys (HP:0000105)2.60647507
85Abnormality of chromosome stability (HP:0003220)2.59281929
86Rickets (HP:0002748)2.58604103
87Vomiting (HP:0002013)2.57594639
88Malnutrition (HP:0004395)2.56869987
89Abnormality of complement system (HP:0005339)2.56847594
90Calcaneovalgus deformity (HP:0001848)2.55238830
91Abnormality of the intrinsic pathway (HP:0010989)2.52840648
92Irritability (HP:0000737)2.50511005
93Ependymoma (HP:0002888)2.47075248
94Neonatal onset (HP:0003623)2.45707355
95Absent radius (HP:0003974)2.44042704
96Spastic diplegia (HP:0001264)2.42472619
97Hypercholesterolemia (HP:0003124)2.42195398
98Polydipsia (HP:0001959)2.41984992
99Abnormal drinking behavior (HP:0030082)2.41984992
100Midline defect of the nose (HP:0004122)2.41776156
101Steatorrhea (HP:0002570)2.40443495
102Nephrolithiasis (HP:0000787)2.38740825
103Renal tubular acidosis (HP:0001947)2.36976874
104Ectopic kidney (HP:0000086)2.36658191
105Unilateral renal agenesis (HP:0000122)2.35126461
106Cerebral edema (HP:0002181)2.34918430
107Aplasia/hypoplasia of the humerus (HP:0006507)2.33341016
108Abnormal enzyme/coenzyme activity (HP:0012379)2.31536197
109Hyperphosphaturia (HP:0003109)2.31256464
110Renal salt wasting (HP:0000127)2.30047845
111Sensorimotor neuropathy (HP:0007141)2.29842471
112Tetany (HP:0001281)2.28725649
113Fused cervical vertebrae (HP:0002949)2.28062470
114Absent forearm bone (HP:0003953)2.24055250
115Aplasia involving forearm bones (HP:0009822)2.24055250
116Skull defect (HP:0001362)2.24000797
117Abnormal hair whorl (HP:0010721)2.23634723
118Abnormality of renin-angiotensin system (HP:0000847)2.23134340
119Hyperaldosteronism (HP:0000859)2.22434265
120Short humerus (HP:0005792)2.22328539
121Acanthocytosis (HP:0001927)2.22076534
122Abnormality of the preputium (HP:0100587)2.21083757
123Stenosis of the external auditory canal (HP:0000402)2.19044643
124Renal agenesis (HP:0000104)2.18508144
125Parakeratosis (HP:0001036)2.17348897
126Aplasia cutis congenita (HP:0001057)2.16571157
127Late onset (HP:0003584)2.16559704
128Triphalangeal thumb (HP:0001199)2.16447196
129Confusion (HP:0001289)2.15573095
130Deformed tarsal bones (HP:0008119)2.14631101
131Bifid tongue (HP:0010297)2.11397688
132Abnormality of alkaline phosphatase activity (HP:0004379)2.10814160
133Systemic lupus erythematosus (HP:0002725)2.10591142
134Small intestinal stenosis (HP:0012848)2.08356708
135Duodenal stenosis (HP:0100867)2.08356708
136Acute encephalopathy (HP:0006846)2.07974382
137Abnormality of the parietal bone (HP:0002696)2.07723801
138Increased nuchal translucency (HP:0010880)2.06628509
139Macrocytic anemia (HP:0001972)2.06352292
140Facial cleft (HP:0002006)2.05632096
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05228164
142Atresia of the external auditory canal (HP:0000413)2.05010046
143Abnormal urine phosphate concentration (HP:0012599)2.04949074
144Hypophosphatemia (HP:0002148)2.04586706
145Pancreatitis (HP:0001733)2.04340516
146Medulloblastoma (HP:0002885)2.03491322
147Absent septum pellucidum (HP:0001331)2.03376134
148Abnormality of the duodenum (HP:0002246)2.02972919
149Myocardial infarction (HP:0001658)2.01479777
150Hypophosphatemic rickets (HP:0004912)2.01086594
151Abnormality of the septum pellucidum (HP:0007375)2.00404391
152Choanal stenosis (HP:0000452)2.00184800
153Esophageal atresia (HP:0002032)2.00067097
154Skin nodule (HP:0200036)1.99656574
155Abnormal umbilical cord blood vessels (HP:0011403)1.99611102
156Single umbilical artery (HP:0001195)1.99611102
157Abnormality of the fetal cardiovascular system (HP:0010948)1.99611102
158Type I transferrin isoform profile (HP:0003642)1.99181853
159Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98118969
160Abnormality of cells of the erythroid lineage (HP:0012130)1.97864716
161Reduced antithrombin III activity (HP:0001976)1.97791352
162Homocystinuria (HP:0002156)1.97203065
163Abnormality of homocysteine metabolism (HP:0010919)1.97203065
164Generalized hypotonia (HP:0001290)1.96369008
165Rectal fistula (HP:0100590)1.96163872
166Rectovaginal fistula (HP:0000143)1.96163872
167Elevated alkaline phosphatase (HP:0003155)1.95321633
168Nausea (HP:0002018)1.94996592
169Maternal diabetes (HP:0009800)1.94845930
170Neoplasm of striated muscle (HP:0009728)1.93752321
171Acute necrotizing encephalopathy (HP:0006965)1.93699766
172Mitral stenosis (HP:0001718)1.93322914
173Preaxial foot polydactyly (HP:0001841)1.92510041
174Abnormal number of erythroid precursors (HP:0012131)1.91792737
175Megaloblastic anemia (HP:0001889)1.89676815
176Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88748900
177Abnormality of the umbilical cord (HP:0010881)1.86838201
178Hypoglycemic seizures (HP:0002173)1.82551342
179Carpal bone hypoplasia (HP:0001498)1.81054193
180Aplasia/Hypoplasia of the breasts (HP:0010311)1.80750052
181Microvesicular hepatic steatosis (HP:0001414)1.80648020
182Pancreatic islet-cell hyperplasia (HP:0004510)1.79974212
183Broad distal phalanx of finger (HP:0009836)1.79432919
184High anterior hairline (HP:0009890)1.78983521
185Partial duplication of thumb phalanx (HP:0009944)1.77489955
186Gastrointestinal atresia (HP:0002589)1.76703302
187Impulsivity (HP:0100710)1.76140453
188Neoplasm of the colon (HP:0100273)1.75371101
189Tracheoesophageal fistula (HP:0002575)1.75170631
190Ectopic anus (HP:0004397)1.74223524
191Agnosia (HP:0010524)1.73560294
192Horseshoe kidney (HP:0000085)1.72373557
193Scrotal hypoplasia (HP:0000046)1.72001461
194Choanal atresia (HP:0000453)1.71479335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.19230679
2WNK35.97683383
3WNK45.70594354
4OXSR15.01350305
5VRK24.27506765
6CDC74.00001466
7BUB13.84401195
8TTK3.71180505
9MKNK23.36864770
10FGFR43.27337735
11TSSK63.08024096
12MKNK13.01967712
13ERN12.76208474
14SRPK12.68003884
15SIK12.60041379
16PBK2.58246389
17NME12.48600976
18STK392.44304038
19PLK32.42147836
20PLK42.35328436
21TAF12.33786470
22ZAK2.31471998
23STK38L2.26965534
24MST1R2.11197450
25INSRR2.10942874
26VRK12.04654949
27ERBB41.99170806
28MST41.80090559
29PLK11.74126467
30STK161.69447303
31NME21.69058251
32NUAK11.67811426
33TRIM281.62977194
34WEE11.58059632
35PDK31.56544095
36PDK41.56544095
37TNIK1.55423469
38PASK1.52423747
39SGK2231.49390981
40SGK4941.49390981
41MAPK111.48053020
42TAOK31.47060657
43MAP2K41.42890899
44DYRK21.40354767
45CHEK21.38418920
46EIF2AK31.34466575
47NEK11.34373378
48BRSK21.33989893
49ALK1.31395470
50PINK11.31258326
51ATR1.30930092
52ABL21.23959255
53PKN21.20940766
54EIF2AK21.18582365
55MAP3K71.17749165
56LATS11.16862168
57BMPR1B1.14667570
58TRIB31.14520684
59SGK31.14108252
60GRK61.13702252
61PTK61.09118667
62DAPK11.08004116
63SGK21.04804574
64SMG11.04307997
65FRK1.04040885
66CDK71.03664410
67NEK21.03134549
68PDK21.02530319
69CDK191.00213622
70ACVR1B0.98772377
71AURKB0.96506621
72DYRK30.96060594
73PIK3CG0.94758671
74PRKAA20.94236642
75TYK20.91974646
76EPHB10.91191943
77CHEK10.89924421
78FLT30.89263477
79NEK90.88204848
80STK380.88088354
81MAP3K30.87862817
82GSK3A0.87548322
83STK40.85431938
84DAPK20.85045739
85JAK20.84053616
86TIE10.83458462
87BRD40.82269534
88ATM0.81786943
89MAP3K140.78923163
90BRSK10.77376865
91PRKAA10.76649817
92PRKCZ0.75770979
93CDK120.75001450
94STK30.74714900
95WNK10.74320697
96EIF2AK10.74094617
97MET0.73733681
98FGFR20.72695677
99DYRK1B0.72485398
100KDR0.71604096
101TGFBR10.70012055
102PAK40.69532593
103MAP2K30.69137975
104FGFR10.68992959
105PTK20.66286501
106TGFBR20.64816916
107MAPK150.64723124
108MAP3K80.64218033
109NLK0.62337860
110CDK20.61658375
111ERBB20.60458315
112CDK40.59466706
113CDK10.59298604
114PDPK10.59079764
115MAPK40.58374873
116PRKACG0.58108126
117CSNK2A10.57666871
118CSNK2A20.55377401
119DYRK1A0.54057185
120CDK30.53160661
121PRKDC0.52679736
122LRRK20.52199187
123AURKA0.52041280
124LATS20.51506988
125RIPK10.51298063
126MAPK120.51136659
127TEC0.50819970
128CSNK1E0.49572015
129TBK10.49353762
130JAK10.48723173
131IRAK30.47405009
132PNCK0.44689231
133MAP3K100.44247394
134STK100.44167910
135MAP3K110.43983342
136DMPK0.43126509
137CSK0.40682748
138RPS6KA40.38243508
139CAMK2G0.38159544
140PDK10.38041000
141CDK90.37465767
142RPS6KB20.36873987
143MAP2K60.36695180
144RPS6KA10.35803850
145IRAK20.33453459
146CLK10.32161207
147DAPK30.31797452
148SGK10.31665071
149PAK30.31380507
150CDK60.31245071
151EPHA40.31118403
152PRKCQ0.30813923
153BRAF0.30788581
154RPS6KL10.30355572
155RPS6KC10.30355572
156CAMK1G0.30082218
157CSNK1G10.28507354
158IGF1R0.28428762
159PRKCG0.24471362
160PRKCA0.23976444
161IRAK10.23545171
162RPS6KA60.23381112
163RPS6KA50.22806109
164FGFR30.22574141
165BCR0.22426967
166PRKCI0.22116938
167CDK180.21882298
168CAMK1D0.21576477
169MTOR0.21413070
170MAPK70.20591197
171MAP3K20.20136562
172BMX0.19793346
173PRKCD0.19095906
174EGFR0.18123900
175FER0.17751843
176MAP2K10.17616015
177CAMK40.17477253
178EPHA30.17210283
179MAP3K50.17042920
180MAP3K60.15830911
181PRKACA0.15728804
182GRK10.15037615
183CSF1R0.14934456

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.36400815
2Mismatch repair_Homo sapiens_hsa034303.95798823
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.80187441
4Proteasome_Homo sapiens_hsa030503.72752129
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.49586305
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16692541
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04835970
8Nitrogen metabolism_Homo sapiens_hsa009103.04399266
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.96074384
10Ribosome_Homo sapiens_hsa030102.84836694
11Non-homologous end-joining_Homo sapiens_hsa034502.83757347
12Base excision repair_Homo sapiens_hsa034102.82714525
13Butanoate metabolism_Homo sapiens_hsa006502.79050679
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.79030881
15RNA polymerase_Homo sapiens_hsa030202.75063977
16Tryptophan metabolism_Homo sapiens_hsa003802.74446058
17Arginine biosynthesis_Homo sapiens_hsa002202.68854070
18Spliceosome_Homo sapiens_hsa030402.66838384
19Homologous recombination_Homo sapiens_hsa034402.62265646
20Fatty acid degradation_Homo sapiens_hsa000712.59023969
21Pentose and glucuronate interconversions_Homo sapiens_hsa000402.56187934
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51905904
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48699550
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46536662
25Propanoate metabolism_Homo sapiens_hsa006402.44394571
26RNA transport_Homo sapiens_hsa030132.43167054
27Peroxisome_Homo sapiens_hsa041462.37914659
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31026732
29Cell cycle_Homo sapiens_hsa041102.23081467
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07053933
31Complement and coagulation cascades_Homo sapiens_hsa046101.98283368
32Nucleotide excision repair_Homo sapiens_hsa034201.94654747
33beta-Alanine metabolism_Homo sapiens_hsa004101.88677820
34Fatty acid metabolism_Homo sapiens_hsa012121.88655263
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.88414549
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85905014
37Fanconi anemia pathway_Homo sapiens_hsa034601.81477718
38PPAR signaling pathway_Homo sapiens_hsa033201.79678948
39Pyruvate metabolism_Homo sapiens_hsa006201.77270546
40RNA degradation_Homo sapiens_hsa030181.76131388
41Protein export_Homo sapiens_hsa030601.71987348
42Histidine metabolism_Homo sapiens_hsa003401.70766416
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69152959
44Bile secretion_Homo sapiens_hsa049761.64916406
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.64428772
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63601512
47Chemical carcinogenesis_Homo sapiens_hsa052041.62477465
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60935104
49Pyrimidine metabolism_Homo sapiens_hsa002401.60880243
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59338363
51Basal transcription factors_Homo sapiens_hsa030221.55783573
52Sulfur metabolism_Homo sapiens_hsa009201.53710888
53Selenocompound metabolism_Homo sapiens_hsa004501.53383997
54Parkinsons disease_Homo sapiens_hsa050121.50024837
55mRNA surveillance pathway_Homo sapiens_hsa030151.49671645
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.48833142
57Phenylalanine metabolism_Homo sapiens_hsa003601.45844557
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44134824
59Retinol metabolism_Homo sapiens_hsa008301.39755227
60Carbon metabolism_Homo sapiens_hsa012001.37427584
61Vitamin digestion and absorption_Homo sapiens_hsa049771.31471479
62Starch and sucrose metabolism_Homo sapiens_hsa005001.29853232
63Caffeine metabolism_Homo sapiens_hsa002321.29209378
64Huntingtons disease_Homo sapiens_hsa050161.28430773
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.24430011
66Biosynthesis of amino acids_Homo sapiens_hsa012301.23367011
67Fatty acid elongation_Homo sapiens_hsa000621.20765672
68Purine metabolism_Homo sapiens_hsa002301.19766289
69Folate biosynthesis_Homo sapiens_hsa007901.18207593
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15953293
71Tyrosine metabolism_Homo sapiens_hsa003501.15697005
72Arginine and proline metabolism_Homo sapiens_hsa003301.15099060
73Staphylococcus aureus infection_Homo sapiens_hsa051501.14338023
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04110632
75Lysine degradation_Homo sapiens_hsa003101.03832296
76Glutathione metabolism_Homo sapiens_hsa004800.99395975
77Thyroid cancer_Homo sapiens_hsa052160.99163418
78Steroid biosynthesis_Homo sapiens_hsa001000.98247605
79ABC transporters_Homo sapiens_hsa020100.95748950
80p53 signaling pathway_Homo sapiens_hsa041150.91275183
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.89770606
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87502214
83Oocyte meiosis_Homo sapiens_hsa041140.83371088
84Sulfur relay system_Homo sapiens_hsa041220.78318025
85Glycerolipid metabolism_Homo sapiens_hsa005610.78226086
86Basal cell carcinoma_Homo sapiens_hsa052170.76544716
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76169482
88Alzheimers disease_Homo sapiens_hsa050100.75835356
89Fat digestion and absorption_Homo sapiens_hsa049750.75131563
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73852630
91Hippo signaling pathway_Homo sapiens_hsa043900.71851681
92Wnt signaling pathway_Homo sapiens_hsa043100.71545306
93TGF-beta signaling pathway_Homo sapiens_hsa043500.67063358
94Pentose phosphate pathway_Homo sapiens_hsa000300.61766947
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61638689
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59204312
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54583012
98Vitamin B6 metabolism_Homo sapiens_hsa007500.53761448
99One carbon pool by folate_Homo sapiens_hsa006700.53542880
100Metabolic pathways_Homo sapiens_hsa011000.51734909
101N-Glycan biosynthesis_Homo sapiens_hsa005100.51734206
102Fructose and mannose metabolism_Homo sapiens_hsa000510.45412853
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41725124
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38585793
105Tight junction_Homo sapiens_hsa045300.38454863
106MicroRNAs in cancer_Homo sapiens_hsa052060.37394645
107Epstein-Barr virus infection_Homo sapiens_hsa051690.36978302
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35645910
109Cardiac muscle contraction_Homo sapiens_hsa042600.34615593
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31347051
111Adherens junction_Homo sapiens_hsa045200.30839683
112Hedgehog signaling pathway_Homo sapiens_hsa043400.30685630
113Bladder cancer_Homo sapiens_hsa052190.29814249
114Colorectal cancer_Homo sapiens_hsa052100.26445718
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25052797
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24745553
117Sphingolipid metabolism_Homo sapiens_hsa006000.24468372
118Fatty acid biosynthesis_Homo sapiens_hsa000610.23051147
119Galactose metabolism_Homo sapiens_hsa000520.20144050
120Insulin resistance_Homo sapiens_hsa049310.19246420
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.18390946
122Collecting duct acid secretion_Homo sapiens_hsa049660.17533153
123Protein digestion and absorption_Homo sapiens_hsa049740.16851843
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15473023
125Mineral absorption_Homo sapiens_hsa049780.14625487
126Systemic lupus erythematosus_Homo sapiens_hsa053220.13547083
127Prostate cancer_Homo sapiens_hsa052150.12882023
128Other glycan degradation_Homo sapiens_hsa005110.11549662
129Renin-angiotensin system_Homo sapiens_hsa046140.10351132
130Prion diseases_Homo sapiens_hsa050200.08914757
131Glucagon signaling pathway_Homo sapiens_hsa049220.05891396
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.05631273
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.04252689
134Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.03471182
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.03148129
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.02120959
137AMPK signaling pathway_Homo sapiens_hsa041520.01574253
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01128489
139Thyroid hormone synthesis_Homo sapiens_hsa049180.00993472
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1735830
141Insulin signaling pathway_Homo sapiens_hsa04910-0.1655454
142Hepatitis C_Homo sapiens_hsa05160-0.1546527
143Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1519549
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1505856
145Regulation of autophagy_Homo sapiens_hsa04140-0.1228398
146Oxidative phosphorylation_Homo sapiens_hsa00190-0.0944637
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0840269
148Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0283899
149Lysosome_Homo sapiens_hsa04142-0.0202560
150Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0171629
151Linoleic acid metabolism_Homo sapiens_hsa00591-0.0102523

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