UHMK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.35729928
2nuclear pore complex assembly (GO:0051292)5.87184616
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.84470638
4locomotory exploration behavior (GO:0035641)5.79354938
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.43699334
6glutamate secretion (GO:0014047)5.15107480
7nuclear pore organization (GO:0006999)5.00791068
8synaptic vesicle exocytosis (GO:0016079)4.97424558
9regulation of synaptic vesicle exocytosis (GO:2000300)4.80832767
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.78543667
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.51626149
12proline transport (GO:0015824)4.48887088
13layer formation in cerebral cortex (GO:0021819)4.48819063
14sodium ion export (GO:0071436)4.43898371
15Golgi transport vesicle coating (GO:0048200)4.35622714
16COPI coating of Golgi vesicle (GO:0048205)4.35622714
17vocalization behavior (GO:0071625)4.35388293
18exploration behavior (GO:0035640)4.23898659
19regulation of synaptic vesicle transport (GO:1902803)4.22893505
20neurotransmitter secretion (GO:0007269)4.22689621
21cellular potassium ion homeostasis (GO:0030007)4.20640921
22pore complex assembly (GO:0046931)4.17237825
23hypotonic response (GO:0006971)4.14374928
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.03108125
25regulation of glutamate receptor signaling pathway (GO:1900449)4.02722117
26protein localization to endosome (GO:0036010)4.00444281
27regulation of clathrin-mediated endocytosis (GO:2000369)3.94781408
28activation of protein kinase A activity (GO:0034199)3.94566405
29iron ion import (GO:0097286)3.90391264
30regulation of ARF protein signal transduction (GO:0032012)3.79448549
31regulation of neuronal synaptic plasticity (GO:0048168)3.76339030
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.74424422
33embryonic process involved in female pregnancy (GO:0060136)3.72592648
34mitotic sister chromatid cohesion (GO:0007064)3.72432765
35protein localization to synapse (GO:0035418)3.68844838
36gamma-aminobutyric acid transport (GO:0015812)3.64794558
37regulation of synapse structural plasticity (GO:0051823)3.64145536
38positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.59050582
39COPII vesicle coating (GO:0048208)3.58070891
40regulation of histone H3-K27 methylation (GO:0061085)3.57178725
41vesicle transport along microtubule (GO:0047496)3.56929765
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.48566158
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.43646202
44neurotransmitter transport (GO:0006836)3.40399075
45neuromuscular process controlling balance (GO:0050885)3.36578292
46glycine transport (GO:0015816)3.34086627
47neuron cell-cell adhesion (GO:0007158)3.33621142
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.31640200
49necroptotic process (GO:0070266)3.31471726
50cerebellar Purkinje cell differentiation (GO:0021702)3.31410999
51neuronal action potential propagation (GO:0019227)3.30966967
52dendritic spine morphogenesis (GO:0060997)3.30533779
53vesicle coating (GO:0006901)3.25746741
54dendrite morphogenesis (GO:0048813)3.23124865
55phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.22203408
56neuromuscular process controlling posture (GO:0050884)3.20985126
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18129459
58long-term memory (GO:0007616)3.16980232
59proline biosynthetic process (GO:0006561)3.16739870
60regulation of neurotransmitter levels (GO:0001505)3.15124282
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11425364
62clathrin coat assembly (GO:0048268)3.10601259
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.08971199
64hepatocyte apoptotic process (GO:0097284)3.08965145
65cell communication by electrical coupling (GO:0010644)3.08862820
66organelle transport along microtubule (GO:0072384)3.07930064
67alanine transport (GO:0032328)3.06086751
68regulation of excitatory postsynaptic membrane potential (GO:0060079)3.02254975
69prepulse inhibition (GO:0060134)3.01622136
70synaptic vesicle endocytosis (GO:0048488)3.01269762
71cell adhesion mediated by integrin (GO:0033627)2.99489469
72membrane raft organization (GO:0031579)2.99451386
73synaptic transmission, glutamatergic (GO:0035249)2.99131745
74potassium ion import (GO:0010107)2.98466712
75axon cargo transport (GO:0008088)2.98064092
76positive regulation of membrane potential (GO:0045838)2.97994531
77regulation of synaptic plasticity (GO:0048167)2.97850877
78establishment of nucleus localization (GO:0040023)2.97690243
79neuron-neuron synaptic transmission (GO:0007270)2.97225857
80negative regulation of protein localization to plasma membrane (GO:1903077)2.96804178
81regulation of neurotransmitter secretion (GO:0046928)2.96705717
82regulation of RNA export from nucleus (GO:0046831)2.95125747
83regulation of postsynaptic membrane potential (GO:0060078)2.94279754
84cytoplasmic mRNA processing body assembly (GO:0033962)2.93957868
85glutamate receptor signaling pathway (GO:0007215)2.92687159
86neurotransmitter-gated ion channel clustering (GO:0072578)2.92419424
87cellular sodium ion homeostasis (GO:0006883)2.89131366
88social behavior (GO:0035176)2.87816964
89intraspecies interaction between organisms (GO:0051703)2.87816964
90regulation of response to tumor cell (GO:0002834)2.87793265
91positive regulation of response to tumor cell (GO:0002836)2.87793265
92positive regulation of immune response to tumor cell (GO:0002839)2.87793265
93regulation of immune response to tumor cell (GO:0002837)2.87793265
94regulation of nucleobase-containing compound transport (GO:0032239)2.86939516
95membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86243889
96mating behavior (GO:0007617)2.84543104
97innervation (GO:0060384)2.83945297
98nerve growth factor signaling pathway (GO:0038180)2.83413434
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81326116
100mammary gland epithelial cell proliferation (GO:0033598)2.80611506
101long-term synaptic potentiation (GO:0060291)2.79781513
102regulation of dendritic spine morphogenesis (GO:0061001)2.79622980
103cellular response to ethanol (GO:0071361)2.79318215
104regulation of vesicle fusion (GO:0031338)2.75594823
105protein localization to microtubule (GO:0035372)2.74666033
106positive regulation of synaptic transmission, GABAergic (GO:0032230)2.74568240
107response to auditory stimulus (GO:0010996)2.73590482
108G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.73552785
109regulation of neurotransmitter transport (GO:0051588)2.73086327
110programmed necrotic cell death (GO:0097300)2.71569283
111response to histamine (GO:0034776)2.69794208
112necrotic cell death (GO:0070265)2.68822503
113neuromuscular process (GO:0050905)2.68368611
114membrane depolarization during action potential (GO:0086010)2.67926043
115positive regulation of neurotransmitter transport (GO:0051590)2.67656139
116protein export from nucleus (GO:0006611)2.67643273
117negative regulation of DNA repair (GO:0045738)2.67136656
118regulation of synaptic transmission, glutamatergic (GO:0051966)2.66109986
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.64480584
120neuron recognition (GO:0008038)2.63873004
121negative regulation of fatty acid transport (GO:2000192)2.63757293
122skin morphogenesis (GO:0043589)2.63309219
123positive regulation of gamma-delta T cell activation (GO:0046645)2.63005371
124dopamine receptor signaling pathway (GO:0007212)2.62968900
125regulation of glucose import in response to insulin stimulus (GO:2001273)2.62956954
126peptidyl-threonine modification (GO:0018210)2.62599222
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.61507164
128mitotic chromosome condensation (GO:0007076)2.60701492
129potassium ion homeostasis (GO:0055075)2.60663856
130suckling behavior (GO:0001967)2.60257486
131membrane hyperpolarization (GO:0060081)2.59173204
132cell migration in hindbrain (GO:0021535)2.58685927
133positive regulation of synaptic transmission (GO:0050806)2.58005122
134chemosensory behavior (GO:0007635)2.57392284
135auditory behavior (GO:0031223)2.57021964
136membrane repolarization (GO:0086009)2.55144772
137antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54749862
138activation of Rac GTPase activity (GO:0032863)2.54085280
139protein targeting to Golgi (GO:0000042)2.53606046
140L-amino acid import (GO:0043092)2.52963804
141definitive hemopoiesis (GO:0060216)2.52889601
142negative regulation of erythrocyte differentiation (GO:0045647)2.52835395
143retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52215706
144membrane depolarization (GO:0051899)2.51197790
145axonal fasciculation (GO:0007413)2.51172662
146hemidesmosome assembly (GO:0031581)2.50346837
147peptidyl-threonine phosphorylation (GO:0018107)2.48539461
148megakaryocyte development (GO:0035855)2.47524838
149cell-substrate junction assembly (GO:0007044)2.47453075
150antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.46647128
151response to laminar fluid shear stress (GO:0034616)2.44497677
152regulation of necroptotic process (GO:0060544)2.43713514
153negative regulation of anoikis (GO:2000811)2.42656090
154positive regulation of protein import into nucleus, translocation (GO:0033160)2.40027110
155dosage compensation (GO:0007549)2.36270399
156negative regulation of necroptotic process (GO:0060546)2.33586499
157negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.32896676
158regulation of protein localization to plasma membrane (GO:1903076)2.31053717
159regulation of mitotic spindle organization (GO:0060236)2.28339408
160regulation of early endosome to late endosome transport (GO:2000641)2.27474598
161regulation of spindle organization (GO:0090224)2.27217215
162regulation of anoikis (GO:2000209)2.26798875
163antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.26373148
164positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.25248341
165regulation of transforming growth factor beta1 production (GO:0032908)2.24288932
166negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.23590477
167focal adhesion assembly (GO:0048041)2.23104521
168cell-substrate adherens junction assembly (GO:0007045)2.23104521
169Golgi organization (GO:0007030)2.22472564
170B cell receptor signaling pathway (GO:0050853)2.21927564
171early endosome to late endosome transport (GO:0045022)2.21634417
172desmosome organization (GO:0002934)2.20688727
173membrane protein ectodomain proteolysis (GO:0006509)2.20240597
174cortical actin cytoskeleton organization (GO:0030866)2.18778028
175positive regulation of cellular response to insulin stimulus (GO:1900078)2.18477909
176negative regulation of interleukin-17 production (GO:0032700)2.17578437
177hepatocyte differentiation (GO:0070365)2.16533626
178antigen processing and presentation via MHC class Ib (GO:0002475)2.15948769
179positive regulation of keratinocyte differentiation (GO:0045618)2.15646355
180regulation of type I interferon-mediated signaling pathway (GO:0060338)2.15536881
181histone phosphorylation (GO:0016572)2.15484013
182cellular protein complex localization (GO:0034629)2.15379993
183pinocytosis (GO:0006907)2.12275290
184response to thyroid hormone (GO:0097066)2.12024874
185cellular response to thyroid hormone stimulus (GO:0097067)2.11886343
186regulation of response to interferon-gamma (GO:0060330)2.11564331
187poly(A)+ mRNA export from nucleus (GO:0016973)2.10997534
188histone H3-K36 demethylation (GO:0070544)2.10435988
189viral entry into host cell (GO:0046718)2.10219236
190regulation of transforming growth factor beta2 production (GO:0032909)2.09701894
191regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.08487956
192antigen processing and presentation of endogenous antigen (GO:0019883)2.08314823
193positive regulation of macrophage differentiation (GO:0045651)2.06739656
194positive regulation of receptor recycling (GO:0001921)2.06167707
195stress fiber assembly (GO:0043149)2.05585240
196regulation of establishment of protein localization to plasma membrane (GO:0090003)2.05318559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.02746880
2EZH2_22144423_ChIP-Seq_EOC_Human3.95658549
3GATA1_22025678_ChIP-Seq_K562_Human3.95575952
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.77233150
5E2F7_22180533_ChIP-Seq_HELA_Human3.54761290
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.70698045
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.53261623
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.50788632
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48891026
10DROSHA_22980978_ChIP-Seq_HELA_Human2.44371953
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.43987238
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42079932
13AR_21909140_ChIP-Seq_LNCAP_Human2.40525631
14GBX2_23144817_ChIP-Seq_PC3_Human2.39203815
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39107846
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37113534
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30746882
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26359967
19REST_21632747_ChIP-Seq_MESCs_Mouse2.24703176
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18066677
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16253868
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13871872
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13709166
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13709166
25AR_21572438_ChIP-Seq_LNCaP_Human2.09446174
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07750273
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06703184
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.04277406
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.04277406
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02907958
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99249447
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.98638485
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95095830
34CLOCK_20551151_ChIP-Seq_293T_Human1.89339449
35FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.89124395
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.86764385
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85712689
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85711893
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.83147016
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.82578221
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80129679
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79404809
43MYC_22102868_ChIP-Seq_BL_Human1.76790876
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76162377
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.71200109
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.70577433
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70345406
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69861877
49ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.69413020
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68336381
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66881907
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.66861109
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66435581
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.65394369
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64205781
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.63276136
57KDM2B_26808549_Chip-Seq_K562_Human1.60672291
58TFEB_21752829_ChIP-Seq_HELA_Human1.60345428
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.60016587
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58702293
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.56960169
62* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55134522
63SMAD4_21799915_ChIP-Seq_A2780_Human1.53744458
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51969090
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51880921
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50862749
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50200656
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.49445897
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49107954
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.49081911
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48634039
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48117012
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.46648853
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43243746
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.42509026
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41624586
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41543695
78TCF7_22412390_ChIP-Seq_EML_Mouse1.40965386
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.39700252
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39326563
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39038887
82MYB_26560356_Chip-Seq_TH2_Human1.38707817
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37667983
84MYB_26560356_Chip-Seq_TH1_Human1.37101607
85* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35904415
86BRD4_25478319_ChIP-Seq_HGPS_Human1.35132809
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34672234
88AR_19668381_ChIP-Seq_PC3_Human1.31931388
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30955645
90CHD1_26751641_Chip-Seq_LNCaP_Human1.30693739
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29841064
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.29365056
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28926985
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28759645
95STAT3_23295773_ChIP-Seq_U87_Human1.27440132
96ZNF274_21170338_ChIP-Seq_K562_Hela1.25973704
97AHR_22903824_ChIP-Seq_MCF-7_Human1.25810895
98RXR_22108803_ChIP-Seq_LS180_Human1.25728790
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25592266
100KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25174705
101ERG_21242973_ChIP-ChIP_JURKAT_Human1.24849675
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23839534
103* PU_27001747_Chip-Seq_BMDM_Mouse1.21862915
104TP53_16413492_ChIP-PET_HCT116_Human1.20980362
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20731134
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20526148
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20365831
108* RUNX1_22412390_ChIP-Seq_EML_Mouse1.17732721
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.17476203
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17330314
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17016564
112SCL_19346495_ChIP-Seq_HPC-7_Human1.16865950
113STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16802071
114ZNF263_19887448_ChIP-Seq_K562_Human1.16485493
115ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16260281
116AR_25329375_ChIP-Seq_VCAP_Human1.16187395
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15374399
118DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15320933
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15047485
120RUNX_20019798_ChIP-Seq_JUKART_Human1.14969006
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13614693
122ATF3_27146783_Chip-Seq_COLON_Human1.13418727
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13096691
124ESR1_20079471_ChIP-ChIP_T-47D_Human1.12584843
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12289775
126MAF_26560356_Chip-Seq_TH1_Human1.12117849
127TAF15_26573619_Chip-Seq_HEK293_Human1.11805712
128GATA6_25053715_ChIP-Seq_YYC3_Human1.11193514
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10879919
130KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10785650
131SPI1_23547873_ChIP-Seq_NB4_Human1.10416166
132* KDM2B_26808549_Chip-Seq_DND41_Human1.08204703
133SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08117098
134KDM2B_26808549_Chip-Seq_JURKAT_Human1.07954952
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07484244
136CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06910196
137ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05121030
138RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05037142
139IGF1R_20145208_ChIP-Seq_DFB_Human1.04923927
140SALL1_21062744_ChIP-ChIP_HESCs_Human1.04794494
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04607054
142YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04529223
143UBF1/2_26484160_Chip-Seq_HMECs_Human1.03955831
144EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03873051
145* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02391188
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01664900
147RING1B_27294783_Chip-Seq_ESCs_Mouse1.01204610
148KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00955077
149GATA2_19941826_ChIP-Seq_K562_Human1.00256499
150IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00091270
151TCF4_23295773_ChIP-Seq_U87_Human0.99889559
152* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99617708
153GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99493244
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99171827
155STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98495777
156* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98482075
157TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97824906
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.97792797
159CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97523678
160IRF8_21731497_ChIP-ChIP_J774_Mouse0.97188326
161CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96750903
162P300_19829295_ChIP-Seq_ESCs_Human0.96263280
163GATA1_19941826_ChIP-Seq_K562_Human0.95905680
164NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95820148
165IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95731266
166SMAD3_21741376_ChIP-Seq_EPCs_Human0.94912612
167SMAD3_21741376_ChIP-Seq_ESCs_Human0.94823762
168ESR2_21235772_ChIP-Seq_MCF-7_Human0.94141877
169SPI1_23127762_ChIP-Seq_K562_Human0.94099843
170NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93286915
171FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92975892
172P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92660399
173* RING1B_27294783_Chip-Seq_NPCs_Mouse0.91658557
174PRDM14_20953172_ChIP-Seq_ESCs_Human0.91654263
175* SMAD3_21741376_ChIP-Seq_HESCs_Human0.91604570
176SOX2_20726797_ChIP-Seq_SW620_Human0.91484700
177TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90894162
178STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90804850
179KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90630633
180E2F1_21310950_ChIP-Seq_MCF-7_Human0.89969997
181MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89781408
182ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89139786
183VDR_24763502_ChIP-Seq_THP-1_Human0.88298972
184E2F4_17652178_ChIP-ChIP_JURKAT_Human0.88024754
185FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87855459
186DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87825344
187NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87786011
188TBX20_22328084_ChIP-Seq_HEART_Mouse0.87627261
189BCAT_22108803_ChIP-Seq_LS180_Human0.86989610
190FOXA2_19822575_ChIP-Seq_HepG2_Human0.86979241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.72909331
2MP0003635_abnormal_synaptic_transmissio4.01136493
3MP0004270_analgesia3.86416993
4MP0003880_abnormal_central_pattern3.72004874
5MP0010352_gastrointestinal_tract_polyps3.58461173
6MP0008057_abnormal_DNA_replication3.19110454
7MP0002063_abnormal_learning/memory/cond3.12299051
8MP0001968_abnormal_touch/_nociception3.10441501
9MP0009046_muscle_twitch3.01694856
10MP0009745_abnormal_behavioral_response2.97244423
11MP0002064_seizures2.95475428
12MP0005423_abnormal_somatic_nervous2.92883024
13MP0000569_abnormal_digit_pigmentation2.69486484
14MP0002009_preneoplasia2.65702233
15MP0002734_abnormal_mechanical_nocicepti2.57354294
16MP0005451_abnormal_body_composition2.50705412
17MP0002572_abnormal_emotion/affect_behav2.45163544
18MP0009780_abnormal_chondrocyte_physiolo2.42475224
19MP0003191_abnormal_cellular_cholesterol2.37081989
20MP0002909_abnormal_adrenal_gland2.34305810
21MP0002735_abnormal_chemical_nociception2.29793576
22MP0001486_abnormal_startle_reflex2.28968440
23MP0003329_amyloid_beta_deposits2.26664410
24MP0002166_altered_tumor_susceptibility2.25686057
25MP0002822_catalepsy2.23366386
26MP0002733_abnormal_thermal_nociception2.22375383
27MP0003656_abnormal_erythrocyte_physiolo2.21922239
28MP0003566_abnormal_cell_adhesion2.21683687
29MP0001501_abnormal_sleep_pattern2.19319541
30MP0004858_abnormal_nervous_system2.17302934
31MP0002272_abnormal_nervous_system2.14739928
32MP0002736_abnormal_nociception_after2.08793789
33MP0003763_abnormal_thymus_physiology2.08720429
34MP0004811_abnormal_neuron_physiology1.98057403
35MP0001970_abnormal_pain_threshold1.93419210
36* MP0003091_abnormal_cell_migration1.91454755
37MP0010234_abnormal_vibrissa_follicle1.87885068
38MP0002396_abnormal_hematopoietic_system1.86489927
39MP0004808_abnormal_hematopoietic_stem1.85182514
40MP0008569_lethality_at_weaning1.84350939
41MP0002067_abnormal_sensory_capabilities1.79620413
42MP0004924_abnormal_behavior1.78511524
43MP0005386_behavior/neurological_phenoty1.78511524
44MP0001440_abnormal_grooming_behavior1.77517263
45MP0004885_abnormal_endolymph1.72690593
46MP0002006_tumorigenesis1.69816984
47MP0008961_abnormal_basal_metabolism1.69143110
48MP0005409_darkened_coat_color1.68437987
49MP0003633_abnormal_nervous_system1.57794551
50MP0002184_abnormal_innervation1.54659584
51MP0001835_abnormal_antigen_presentation1.53526816
52MP0000604_amyloidosis1.53413354
53MP0003453_abnormal_keratinocyte_physiol1.52662822
54MP0006276_abnormal_autonomic_nervous1.50167625
55MP0004947_skin_inflammation1.46963081
56MP0002557_abnormal_social/conspecific_i1.46462839
57MP0000778_abnormal_nervous_system1.42607416
58MP0000955_abnormal_spinal_cord1.41954376
59MP0003172_abnormal_lysosome_physiology1.40201691
60MP0005551_abnormal_eye_electrophysiolog1.39273378
61MP0003950_abnormal_plasma_membrane1.38980942
62MP0002882_abnormal_neuron_morphology1.36071944
63MP0003690_abnormal_glial_cell1.34596612
64MP0002066_abnormal_motor_capabilities/c1.31493807
65MP0000858_altered_metastatic_potential1.31423718
66MP0003828_pulmonary_edema1.28866019
67MP0003631_nervous_system_phenotype1.28021394
68MP0003221_abnormal_cardiomyocyte_apopto1.27443404
69MP0003303_peritoneal_inflammation1.25679978
70MP0005464_abnormal_platelet_physiology1.25096328
71MP0003879_abnormal_hair_cell1.24911628
72MP0008260_abnormal_autophagy1.24393790
73MP0010307_abnormal_tumor_latency1.24300869
74MP0000015_abnormal_ear_pigmentation1.23075337
75MP0001851_eye_inflammation1.22779066
76MP0002229_neurodegeneration1.22318606
77MP0005646_abnormal_pituitary_gland1.20678873
78MP0008438_abnormal_cutaneous_collagen1.20575154
79MP0004264_abnormal_extraembryonic_tissu1.20356402
80MP0002060_abnormal_skin_morphology1.19980957
81MP0004130_abnormal_muscle_cell1.19182357
82MP0003787_abnormal_imprinting1.17813285
83* MP0005621_abnormal_cell_physiology1.17212437
84MP0010155_abnormal_intestine_physiology1.16724200
85MP0005408_hypopigmentation1.16662814
86MP0010678_abnormal_skin_adnexa1.16524414
87MP0002090_abnormal_vision1.14118569
88MP0003075_altered_response_to1.12919345
89MP0005666_abnormal_adipose_tissue1.10611052
90MP0005023_abnormal_wound_healing1.10173475
91MP0003300_gastrointestinal_ulcer1.09813766
92MP0005645_abnormal_hypothalamus_physiol1.09320241
93MP0001984_abnormal_olfaction1.07642690
94MP0001873_stomach_inflammation1.07419811
95MP0003634_abnormal_glial_cell1.05903972
96MP0008874_decreased_physiological_sensi1.05903172
97MP0004510_myositis1.04614480
98MP0005535_abnormal_body_temperature1.04542573
99MP0009697_abnormal_copulation1.04278259
100MP0003868_abnormal_feces_composition1.03903643
101MP0005058_abnormal_lysosome_morphology1.03764926
102MP0001216_abnormal_epidermal_layer1.03630962
103MP0003436_decreased_susceptibility_to1.02859917
104MP0001661_extended_life_span1.00926574
105MP0003045_fibrosis1.00726145
106MP0005187_abnormal_penis_morphology0.99333169
107MP0001299_abnormal_eye_distance/0.99322102
108MP0008872_abnormal_physiological_respon0.98685516
109MP0000371_diluted_coat_color0.97915632
110MP0000685_abnormal_immune_system0.97466863
111MP0002152_abnormal_brain_morphology0.97116669
112MP0000350_abnormal_cell_proliferation0.96442811
113MP0002398_abnormal_bone_marrow0.96320573
114MP0000627_abnormal_mammary_gland0.96262164
115MP0002796_impaired_skin_barrier0.95063928
116MP0003632_abnormal_nervous_system0.95007065
117MP0003448_altered_tumor_morphology0.94237883
118MP0000013_abnormal_adipose_tissue0.94186831
119MP0002086_abnormal_extraembryonic_tissu0.91858442
120MP0001853_heart_inflammation0.91649411
121MP0001502_abnormal_circadian_rhythm0.91618617
122MP0001177_atelectasis0.90957744
123MP0000920_abnormal_myelination0.89776350
124MP0005000_abnormal_immune_tolerance0.88964459
125MP0000703_abnormal_thymus_morphology0.88897484
126MP0005167_abnormal_blood-brain_barrier0.88831489
127MP0004957_abnormal_blastocyst_morpholog0.86573199
128MP0000465_gastrointestinal_hemorrhage0.85715850
129MP0001849_ear_inflammation0.84940718
130MP0001800_abnormal_humoral_immune0.84752472
131MP0001915_intracranial_hemorrhage0.84453570
132MP0000733_abnormal_muscle_development0.84160970
133MP0001730_embryonic_growth_arrest0.83273952
134MP0005375_adipose_tissue_phenotype0.83075588
135MP0003122_maternal_imprinting0.82613253
136MP0002419_abnormal_innate_immunity0.82443387
137MP0002452_abnormal_antigen_presenting0.80915602
138* MP0003077_abnormal_cell_cycle0.80810079
139MP0002722_abnormal_immune_system0.79778989
140MP0005623_abnormal_meninges_morphology0.78433112
141MP0002069_abnormal_eating/drinking_beha0.78432384
142MP0002405_respiratory_system_inflammati0.78316730
143MP0005501_abnormal_skin_physiology0.78209681
144MP0003252_abnormal_bile_duct0.77763069
145* MP0005384_cellular_phenotype0.77710817
146MP0000609_abnormal_liver_physiology0.77318258
147MP0002971_abnormal_brown_adipose0.77026689
148MP0003111_abnormal_nucleus_morphology0.76244170
149MP0003984_embryonic_growth_retardation0.76176728
150MP0005387_immune_system_phenotype0.76158140
151MP0001790_abnormal_immune_system0.76158140
152MP0008007_abnormal_cellular_replicative0.75312038
153MP0009115_abnormal_fat_cell0.74618373
154MP0002896_abnormal_bone_mineralization0.74522140
155MP0002420_abnormal_adaptive_immunity0.74052666
156MP0002998_abnormal_bone_remodeling0.73835392
157MP0000689_abnormal_spleen_morphology0.73791687
158MP0001819_abnormal_immune_cell0.72974683
159MP0002088_abnormal_embryonic_growth/wei0.72843410
160MP0002019_abnormal_tumor_incidence0.72296802
161MP0001881_abnormal_mammary_gland0.71056752
162MP0005166_decreased_susceptibility_to0.69327919
163MP0004085_abnormal_heartbeat0.66362275
164MP0001905_abnormal_dopamine_level0.66274301
165MP0001348_abnormal_lacrimal_gland0.64962045
166MP0000747_muscle_weakness0.64644599
167MP0004233_abnormal_muscle_weight0.63532729
168MP0004142_abnormal_muscle_tone0.61974889
169MP0003183_abnormal_peptide_metabolism0.58131267
170MP0005253_abnormal_eye_physiology0.57476328
171MP0004742_abnormal_vestibular_system0.57396910
172MP0004484_altered_response_of0.56593349
173MP0002752_abnormal_somatic_nervous0.55279957
174MP0003283_abnormal_digestive_organ0.53546954
175MP0005076_abnormal_cell_differentiation0.52205283
176MP0000003_abnormal_adipose_tissue0.51091080
177MP0002877_abnormal_melanocyte_morpholog0.48646584
178MP0010769_abnormal_survival0.48410058
179MP0002089_abnormal_postnatal_growth/wei0.47496121
180MP0004185_abnormal_adipocyte_glucose0.47336588
181MP0003705_abnormal_hypodermis_morpholog0.47130953
182MP0003956_abnormal_body_size0.46471403
183MP0001943_abnormal_respiration0.45492210
184MP0000751_myopathy0.45435837
185MP0000639_abnormal_adrenal_gland0.44860862

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.43786201
2Focal motor seizures (HP:0011153)5.15394064
3Focal seizures (HP:0007359)4.59261273
4Visual hallucinations (HP:0002367)4.57821484
5Papilledema (HP:0001085)4.43664198
6Action tremor (HP:0002345)4.19412756
7Supranuclear gaze palsy (HP:0000605)3.90288468
8Osteolytic defects of the hand bones (HP:0009699)3.67748981
9Osteolytic defects of the phalanges of the hand (HP:0009771)3.67748981
10Progressive cerebellar ataxia (HP:0002073)3.59276419
11Mutism (HP:0002300)3.44264928
12Urinary bladder sphincter dysfunction (HP:0002839)3.35759746
13Termporal pattern (HP:0011008)3.32012055
14Insidious onset (HP:0003587)3.32012055
15Epileptic encephalopathy (HP:0200134)3.20989566
16Absence seizures (HP:0002121)3.19816903
17Atonic seizures (HP:0010819)3.14460502
18Postural instability (HP:0002172)3.13658029
19Ankle clonus (HP:0011448)3.11009537
20Truncal ataxia (HP:0002078)3.10412874
21Impaired vibration sensation in the lower limbs (HP:0002166)3.10393158
22Abnormality of oral frenula (HP:0000190)3.08368091
23Generalized tonic-clonic seizures (HP:0002069)3.07150196
24Subacute progressive viral hepatitis (HP:0006572)3.02955512
25Febrile seizures (HP:0002373)3.01226879
26Depression (HP:0000716)3.00880783
27Urinary urgency (HP:0000012)3.00565042
28Spinal cord lesions (HP:0100561)2.95537352
29Syringomyelia (HP:0003396)2.95537352
30Impaired social interactions (HP:0000735)2.89571561
31Abnormal social behavior (HP:0012433)2.89571561
32Poor eye contact (HP:0000817)2.86189067
33Genetic anticipation (HP:0003743)2.83124831
34Macroorchidism (HP:0000053)2.82773279
35Dialeptic seizures (HP:0011146)2.78519215
36Dysmetric saccades (HP:0000641)2.65211819
37Dysdiadochokinesis (HP:0002075)2.64846347
38Drooling (HP:0002307)2.59548365
39Excessive salivation (HP:0003781)2.59548365
40Dysmetria (HP:0001310)2.58928917
41Broad-based gait (HP:0002136)2.58748573
42Abnormal eating behavior (HP:0100738)2.58574277
43Arterial tortuosity (HP:0005116)2.57533024
44Intention tremor (HP:0002080)2.56677806
45Impaired smooth pursuit (HP:0007772)2.55735691
46Cerebral inclusion bodies (HP:0100314)2.53667213
47Abnormality of the lower motor neuron (HP:0002366)2.52985303
48Acute myeloid leukemia (HP:0004808)2.52745740
49Papillary thyroid carcinoma (HP:0002895)2.52254128
50Sparse lateral eyebrow (HP:0005338)2.52239727
51Spastic gait (HP:0002064)2.49887333
52Gaze-evoked nystagmus (HP:0000640)2.47377461
53Hemiplegia (HP:0002301)2.46484137
54Abnormality of the corticospinal tract (HP:0002492)2.45033594
55Inappropriate behavior (HP:0000719)2.41958105
56Slow saccadic eye movements (HP:0000514)2.41006906
57Torticollis (HP:0000473)2.39917764
58Fatigue (HP:0012378)2.38755926
59Abnormality of ocular smooth pursuit (HP:0000617)2.35317226
60Anxiety (HP:0000739)2.34769562
61Deep philtrum (HP:0002002)2.33860994
62Absent frontal sinuses (HP:0002688)2.30923903
63Bradykinesia (HP:0002067)2.30823117
64Agitation (HP:0000713)2.30534346
65Neurofibrillary tangles (HP:0002185)2.29127771
66Pheochromocytoma (HP:0002666)2.28690154
67Flat acetabular roof (HP:0003180)2.27131237
68Megalencephaly (HP:0001355)2.26286197
69Vascular tortuosity (HP:0004948)2.25677605
70Abnormality of binocular vision (HP:0011514)2.25423212
71Diplopia (HP:0000651)2.25423212
72T lymphocytopenia (HP:0005403)2.24891236
73Asymmetry of the thorax (HP:0001555)2.24241200
74Spondylolisthesis (HP:0003302)2.22865545
75Insomnia (HP:0100785)2.22689924
76Eczematoid dermatitis (HP:0000976)2.22186346
77Scanning speech (HP:0002168)2.21841060
78Stereotypic behavior (HP:0000733)2.18680859
79Relative macrocephaly (HP:0004482)2.17122932
80Progressive inability to walk (HP:0002505)2.17016858
81Central scotoma (HP:0000603)2.14998628
82Aqueductal stenosis (HP:0002410)2.14451039
83Ventricular fibrillation (HP:0001663)2.14124865
84Coarse hair (HP:0002208)2.13791450
85Lower limb muscle weakness (HP:0007340)2.13144923
86Pointed chin (HP:0000307)2.09041205
87Apathy (HP:0000741)2.08567622
88Resting tremor (HP:0002322)2.08422273
89Curly hair (HP:0002212)2.07314982
90Neuronal loss in central nervous system (HP:0002529)2.07182609
91Increased mean platelet volume (HP:0011877)2.07180348
92Impaired vibratory sensation (HP:0002495)2.06827454
93Viral hepatitis (HP:0006562)2.06444524
94Short nail (HP:0001799)2.03444513
95Focal dystonia (HP:0004373)2.02659155
96Mitral stenosis (HP:0001718)2.02148733
97Vertebral compression fractures (HP:0002953)2.00686810
98Amyotrophic lateral sclerosis (HP:0007354)1.99585955
99Periodontitis (HP:0000704)1.99471226
100Ankyloglossia (HP:0010296)1.98858961
101Abnormal platelet volume (HP:0011876)1.98287421
102Interstitial pulmonary disease (HP:0006530)1.97828892
103Glucose intolerance (HP:0000833)1.97696357
104Hypercortisolism (HP:0001578)1.95865973
105Hyperventilation (HP:0002883)1.94858949
106Postural tremor (HP:0002174)1.94816103
107Recurrent viral infections (HP:0004429)1.94788091
108Abnormality of T cell number (HP:0011839)1.94378924
109Status epilepticus (HP:0002133)1.93955011
110Tetraparesis (HP:0002273)1.93929025
111Menstrual irregularities (HP:0000858)1.93795557
112Rapidly progressive (HP:0003678)1.93564204
113Annular pancreas (HP:0001734)1.93410044
114Broad face (HP:0000283)1.92720084
115Abnormality of the distal phalanges of the toes (HP:0010182)1.92413609
116Heterotopia (HP:0002282)1.92327242
117Premature rupture of membranes (HP:0001788)1.92098927
118Distal lower limb amyotrophy (HP:0008944)1.91796211
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.90800088
120Neonatal hypoglycemia (HP:0001998)1.90618001
121Dilatation of the ascending aorta (HP:0005111)1.90381037
122Cutaneous melanoma (HP:0012056)1.89178725
123Amblyopia (HP:0000646)1.87962439
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87892307
125Abnormality of the common coagulation pathway (HP:0010990)1.87769583
126Myocardial infarction (HP:0001658)1.87719933
127Chronic diarrhea (HP:0002028)1.86920110
128Craniofacial dystonia (HP:0012179)1.86776458
129Clonus (HP:0002169)1.86587596
130Hammertoe (HP:0001765)1.85041168
131Abnormality of the fingertips (HP:0001211)1.84969788
132Limb dystonia (HP:0002451)1.84337828
133Micronodular cirrhosis (HP:0001413)1.84312643
134Hyperacusis (HP:0010780)1.83770500
135Overgrowth (HP:0001548)1.83206747
136Colitis (HP:0002583)1.83101204
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82928120
138Rigidity (HP:0002063)1.82800352
139Diminished motivation (HP:0000745)1.82582394
140Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.81958494
141Cubitus valgus (HP:0002967)1.81677118
142Tetraplegia (HP:0002445)1.80542001
143Neuroendocrine neoplasm (HP:0100634)1.79970409
144Subaortic stenosis (HP:0001682)1.79961272
145Abnormality of the left ventricular outflow tract (HP:0011103)1.79961272
146Spastic tetraparesis (HP:0001285)1.79117379
147Intellectual disability, profound (HP:0002187)1.78559671
148Neoplasm of the peripheral nervous system (HP:0100007)1.78510231
149Lower limb asymmetry (HP:0100559)1.78233913
150Bundle branch block (HP:0011710)1.77902176
151Polycythemia (HP:0001901)1.77342105
152Abnormality of saccadic eye movements (HP:0000570)1.77167526
153Orthostatic hypotension (HP:0001278)1.77084215
154Epileptiform EEG discharges (HP:0011182)1.76896463
155EEG with generalized epileptiform discharges (HP:0011198)1.76883793
156Abnormal glucose tolerance (HP:0001952)1.76385412
157Hypsarrhythmia (HP:0002521)1.75047274
158Gait ataxia (HP:0002066)1.74739948
159Entropion (HP:0000621)1.74370947
160Lower limb amyotrophy (HP:0007210)1.72947586
161Abnormality of macular pigmentation (HP:0008002)1.72743653
162Gingivitis (HP:0000230)1.72030742
163Aortic aneurysm (HP:0004942)1.71904874
164Autoimmune hemolytic anemia (HP:0001890)1.71803079
165Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.71448970
166Delayed closure of the anterior fontanelle (HP:0001476)1.71119823
167Increased connective tissue (HP:0009025)1.69945001
168Wormian bones (HP:0002645)1.68995829
169Abnormality of the gastric mucosa (HP:0004295)1.67486013
170Reduced subcutaneous adipose tissue (HP:0003758)1.67239292
171Cellulitis (HP:0100658)1.64186955
172Freckling (HP:0001480)1.63200203
173Spontaneous hematomas (HP:0007420)1.62327896
174Vertebral arch anomaly (HP:0008438)1.61115784
175Abnormal foot bone ossification (HP:0010675)1.60956432
176Thickened calvaria (HP:0002684)1.59459108
177Osteomyelitis (HP:0002754)1.59395403
178Thyroid carcinoma (HP:0002890)1.58277932
179Lower limb hyperreflexia (HP:0002395)1.57542584
180Decreased motor nerve conduction velocity (HP:0003431)1.57403243
181Bilateral sensorineural hearing impairment (HP:0008619)1.57233881
182Dislocated radial head (HP:0003083)1.56261621
183Deviation of the thumb (HP:0009603)1.54188244
184Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.52814879
185Sandal gap (HP:0001852)1.52434550
186Gastrointestinal inflammation (HP:0004386)1.51711983
187Bladder neoplasm (HP:0009725)1.51337104
188Bladder carcinoma (HP:0002862)1.51337104
189Germ cell neoplasia (HP:0100728)1.51148202
190Protrusio acetabuli (HP:0003179)1.50904951
191Short chin (HP:0000331)1.50813842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.54944324
2NTRK33.86098291
3PRPF4B3.22121883
4MST1R3.19809572
5MAP3K43.07055242
6MARK13.01659318
7TRPM73.01090722
8KSR22.85074773
9MINK12.70067854
10PAK62.47428760
11CDK122.42257669
12EPHA42.32776926
13MAP3K142.22781588
14BMPR22.19387259
15MAP2K42.15718014
16NEK92.13179146
17MAP3K22.05850670
18CAMKK12.05383151
19LATS22.04208746
20EIF2AK12.00465627
21NTRK11.99006999
22MAP2K71.95061337
23DAPK21.81609191
24PRKD31.79198620
25RET1.74907610
26NTRK21.74081482
27STK381.73880266
28CDK61.67273160
29SCYL21.65881721
30TTN1.65321255
31RIPK41.62043318
32EEF2K1.59733715
33TAOK11.57033672
34IRAK31.54373578
35KSR11.54194734
36MAP3K121.49944181
37ICK1.45309388
38BRD41.40954664
39EIF2AK31.39849933
40MAP2K31.39781161
41CDK51.38449703
42CAMK1G1.36891603
43TYK21.31264524
44MET1.30584839
45ALK1.30300924
46PRKCH1.27855231
47TYRO31.26740234
48MAP3K131.26068666
49SIK21.24324686
50SIK31.20046654
51EPHA21.19277124
52AKT31.18936398
53FGFR41.18411308
54LMTK21.16231458
55SGK31.14564705
56RIPK11.11614023
57YES11.11112234
58MAP3K101.10852667
59MELK1.07911918
60GRK51.06007803
61TRIB31.05866251
62ERBB31.04334080
63JAK31.02742319
64STK111.00829268
65FES1.00357244
66PDK10.99533406
67BRSK20.98305102
68ZAP700.97971758
69MST40.96756135
70WNK10.95599422
71PBK0.95512160
72CAMKK20.93299162
73PAK40.93243170
74STK100.93014240
75PHKG10.92667182
76PHKG20.92667182
77CAMK1D0.92623171
78STK30.92317061
79PAK30.91908424
80CSNK1G20.90991596
81SGK20.89314776
82SGK4940.89171471
83SGK2230.89171471
84MAP3K30.89046481
85SMG10.88189400
86SIK10.87878281
87PDPK10.85769350
88PLK20.85417843
89DAPK10.85328060
90RAF10.84192517
91FGFR20.81709381
92PRKCG0.81651299
93ARAF0.81478615
94MAP3K10.81122010
95EPHB10.80923743
96FRK0.77981652
97ERBB40.76754932
98RPS6KB20.76333126
99PTK20.75862298
100NEK60.75282107
101PKN20.75206614
102NEK10.74084906
103TGFBR20.73727218
104MAPK110.72277831
105PNCK0.70562071
106ERN10.69869759
107CDK140.68432928
108SGK10.67748979
109CSK0.67714938
110MTOR0.67370918
111FGFR30.66495402
112MARK20.66430346
113DMPK0.65768231
114CDK150.65678448
115BLK0.65437952
116CDK180.64932179
117CAMK10.64472603
118MAP3K70.63022323
119PDGFRA0.62841267
120JAK10.62239818
121MAPK130.62061922
122STK390.60887012
123UHMK10.60259771
124TSSK60.60252013
125MAP3K80.59488242
126PDGFRB0.58730958
127MAPK100.56788274
128TEC0.56399447
129PRKCZ0.56357850
130CAMK2A0.55919838
131LATS10.55363152
132PAK20.54867641
133FYN0.54771244
134CDK190.54538357
135PIK3CG0.54483681
136CDK11A0.53128208
137RPS6KA30.52035814
138JAK20.48682380
139BTK0.48677758
140HCK0.48434209
141RPS6KA20.47863559
142RPS6KB10.47503569
143CDK40.47261694
144EIF2AK20.46687200
145BMX0.46306881
146PTK60.46035263
147MAP2K10.45479525
148STK240.44147861
149IRAK40.44113500
150MOS0.42041155
151MAP3K50.40102989
152MAP3K60.40100464
153IRAK10.39713700
154TNK20.39382410
155LRRK20.38389882
156FER0.36936589
157ILK0.36662029
158TTK0.36066881
159STK40.35930130
160OXSR10.34790062
161CDC42BPA0.34095372
162DYRK1A0.33692145
163PRKCB0.33500021
164PRKAA10.33032496
165PTK2B0.31061482
166PINK10.28588663
167CSNK1D0.28275665
168HIPK20.27986086

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.76087166
2Nitrogen metabolism_Homo sapiens_hsa009102.36149985
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32038844
4Olfactory transduction_Homo sapiens_hsa047402.31926507
5Nicotine addiction_Homo sapiens_hsa050332.29571728
6Long-term potentiation_Homo sapiens_hsa047202.19860400
7GABAergic synapse_Homo sapiens_hsa047272.09230790
8Circadian entrainment_Homo sapiens_hsa047132.03063776
9Glutamatergic synapse_Homo sapiens_hsa047241.92109512
10Dopaminergic synapse_Homo sapiens_hsa047281.85433156
11Thyroid cancer_Homo sapiens_hsa052161.85317640
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85293291
13Morphine addiction_Homo sapiens_hsa050321.83812880
14Amphetamine addiction_Homo sapiens_hsa050311.79924733
15Acute myeloid leukemia_Homo sapiens_hsa052211.78373475
16Salivary secretion_Homo sapiens_hsa049701.77320321
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70738231
18Phototransduction_Homo sapiens_hsa047441.70120870
19Cholinergic synapse_Homo sapiens_hsa047251.69197433
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.68320773
21Gastric acid secretion_Homo sapiens_hsa049711.67922721
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64427862
23Insulin secretion_Homo sapiens_hsa049111.59884944
24Measles_Homo sapiens_hsa051621.55684400
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54529574
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51100062
27Small cell lung cancer_Homo sapiens_hsa052221.48732926
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44948212
29Type II diabetes mellitus_Homo sapiens_hsa049301.42960292
30Renin secretion_Homo sapiens_hsa049241.42953079
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42745359
32Glioma_Homo sapiens_hsa052141.41975971
33Hepatitis B_Homo sapiens_hsa051611.39690638
34Prostate cancer_Homo sapiens_hsa052151.36352911
35GnRH signaling pathway_Homo sapiens_hsa049121.36014501
36Oxytocin signaling pathway_Homo sapiens_hsa049211.35637886
37Cocaine addiction_Homo sapiens_hsa050301.33953247
38Dorso-ventral axis formation_Homo sapiens_hsa043201.30418125
39Long-term depression_Homo sapiens_hsa047301.29384841
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23371502
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23146896
42Influenza A_Homo sapiens_hsa051641.22671048
43Estrogen signaling pathway_Homo sapiens_hsa049151.21706820
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21547592
45Toxoplasmosis_Homo sapiens_hsa051451.20991997
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20757659
47Hepatitis C_Homo sapiens_hsa051601.19158311
48Adherens junction_Homo sapiens_hsa045201.17852653
49Gap junction_Homo sapiens_hsa045401.14048811
50Focal adhesion_Homo sapiens_hsa045101.13943247
51Osteoclast differentiation_Homo sapiens_hsa043801.13856568
52ErbB signaling pathway_Homo sapiens_hsa040121.13427713
53Serotonergic synapse_Homo sapiens_hsa047261.11817308
54FoxO signaling pathway_Homo sapiens_hsa040681.11105342
55Other glycan degradation_Homo sapiens_hsa005111.10744356
56mTOR signaling pathway_Homo sapiens_hsa041501.10586187
57Bladder cancer_Homo sapiens_hsa052191.10581639
58cAMP signaling pathway_Homo sapiens_hsa040241.09810947
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.08385959
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.07989411
61Viral carcinogenesis_Homo sapiens_hsa052031.07778872
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07775883
63MicroRNAs in cancer_Homo sapiens_hsa052061.06952083
64Taste transduction_Homo sapiens_hsa047421.02651511
65Neurotrophin signaling pathway_Homo sapiens_hsa047221.01460045
66Leishmaniasis_Homo sapiens_hsa051401.00775663
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00656846
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98567044
69Calcium signaling pathway_Homo sapiens_hsa040200.97862079
70Apoptosis_Homo sapiens_hsa042100.97373582
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.93739155
72Legionellosis_Homo sapiens_hsa051340.93598976
73Shigellosis_Homo sapiens_hsa051310.92954807
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92567390
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91338110
76TNF signaling pathway_Homo sapiens_hsa046680.89680913
77VEGF signaling pathway_Homo sapiens_hsa043700.89485161
78Choline metabolism in cancer_Homo sapiens_hsa052310.87784981
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.87490075
80Endometrial cancer_Homo sapiens_hsa052130.86328177
81Non-small cell lung cancer_Homo sapiens_hsa052230.85673797
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83903458
83Herpes simplex infection_Homo sapiens_hsa051680.83703943
84Bile secretion_Homo sapiens_hsa049760.83189215
85Axon guidance_Homo sapiens_hsa043600.82135511
86Melanogenesis_Homo sapiens_hsa049160.81972085
87Tuberculosis_Homo sapiens_hsa051520.80859660
88Thyroid hormone synthesis_Homo sapiens_hsa049180.80769452
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80191419
90Amoebiasis_Homo sapiens_hsa051460.79712852
91Renal cell carcinoma_Homo sapiens_hsa052110.79240394
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76466065
93Oocyte meiosis_Homo sapiens_hsa041140.76413993
94MAPK signaling pathway_Homo sapiens_hsa040100.75602965
95Endocytosis_Homo sapiens_hsa041440.73855003
96p53 signaling pathway_Homo sapiens_hsa041150.73333516
97HIF-1 signaling pathway_Homo sapiens_hsa040660.72708211
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72068350
99Insulin signaling pathway_Homo sapiens_hsa049100.70290682
100Cell cycle_Homo sapiens_hsa041100.70160433
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.70145962
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.70002645
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69159640
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67674081
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66745300
106HTLV-I infection_Homo sapiens_hsa051660.65347232
107Collecting duct acid secretion_Homo sapiens_hsa049660.65074495
108Prolactin signaling pathway_Homo sapiens_hsa049170.64716451
109Non-homologous end-joining_Homo sapiens_hsa034500.64278780
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63899672
111Pancreatic secretion_Homo sapiens_hsa049720.62976277
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62904882
113Glucagon signaling pathway_Homo sapiens_hsa049220.62650238
114Inositol phosphate metabolism_Homo sapiens_hsa005620.61875584
115Chemokine signaling pathway_Homo sapiens_hsa040620.61342435
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60988438
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60752013
118Arginine biosynthesis_Homo sapiens_hsa002200.60354021
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59938812
120Malaria_Homo sapiens_hsa051440.59872833
121Melanoma_Homo sapiens_hsa052180.59552317
122Rap1 signaling pathway_Homo sapiens_hsa040150.58943183
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58245437
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57878067
125Viral myocarditis_Homo sapiens_hsa054160.57740810
126Sphingolipid metabolism_Homo sapiens_hsa006000.57585790
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57468967
128Ras signaling pathway_Homo sapiens_hsa040140.57323507
129Colorectal cancer_Homo sapiens_hsa052100.56930307
130Salmonella infection_Homo sapiens_hsa051320.56076738
131Pentose phosphate pathway_Homo sapiens_hsa000300.56016735
132Circadian rhythm_Homo sapiens_hsa047100.54801598
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54546422
134Chronic myeloid leukemia_Homo sapiens_hsa052200.53748090
135Pancreatic cancer_Homo sapiens_hsa052120.53643068
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.53379745
137Dilated cardiomyopathy_Homo sapiens_hsa054140.53332742
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53286400
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52671089
140Platelet activation_Homo sapiens_hsa046110.51784678
141Hematopoietic cell lineage_Homo sapiens_hsa046400.51154566
142Vitamin B6 metabolism_Homo sapiens_hsa007500.49647307
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.47937961
144Fatty acid biosynthesis_Homo sapiens_hsa000610.47423001
145Pathways in cancer_Homo sapiens_hsa052000.47155840
146Prion diseases_Homo sapiens_hsa050200.46548893
147B cell receptor signaling pathway_Homo sapiens_hsa046620.46450818
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46256801
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45913810
150Insulin resistance_Homo sapiens_hsa049310.45673735
151T cell receptor signaling pathway_Homo sapiens_hsa046600.44520020
152Type I diabetes mellitus_Homo sapiens_hsa049400.43507740
153AMPK signaling pathway_Homo sapiens_hsa041520.38253309
154Vibrio cholerae infection_Homo sapiens_hsa051100.37733514
155Proteoglycans in cancer_Homo sapiens_hsa052050.37689633

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