UHRF1BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome organization (GO:0034723)5.74293507
2DNA replication-dependent nucleosome assembly (GO:0006335)5.74293507
3regulation of somitogenesis (GO:0014807)5.15393023
4replicative senescence (GO:0090399)5.12607332
5positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.90713186
6positive regulation of digestive system process (GO:0060456)4.83618615
7positive regulation of prostaglandin secretion (GO:0032308)4.75237472
8regulation of prostaglandin secretion (GO:0032306)4.70024191
9regulation of DNA endoreduplication (GO:0032875)4.44649976
10pre-miRNA processing (GO:0031054)4.43005878
11viral mRNA export from host cell nucleus (GO:0046784)4.13553919
12nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)4.08538533
13positive regulation of fatty acid beta-oxidation (GO:0032000)4.05216412
14alpha-linolenic acid metabolic process (GO:0036109)3.99705152
15sulfation (GO:0051923)3.98569568
16regulation of DNA damage checkpoint (GO:2000001)3.92726731
17negative regulation of DNA repair (GO:0045738)3.89489958
18regulation of fatty acid beta-oxidation (GO:0031998)3.88622238
19monoubiquitinated protein deubiquitination (GO:0035520)3.82267589
20negative regulation of systemic arterial blood pressure (GO:0003085)3.81949290
21regulation of translational fidelity (GO:0006450)3.77181099
22lysine metabolic process (GO:0006553)3.72939721
23lysine catabolic process (GO:0006554)3.72939721
24T cell mediated immunity (GO:0002456)3.72836770
25positive regulation of cardiac muscle cell differentiation (GO:2000727)3.71910397
26interkinetic nuclear migration (GO:0022027)3.66624894
27nuclear pore complex assembly (GO:0051292)3.63540678
28innate immune response in mucosa (GO:0002227)3.62676386
29prenylation (GO:0097354)3.60351078
30protein prenylation (GO:0018342)3.60351078
31positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.59859722
32spleen development (GO:0048536)3.57865747
33cysteine metabolic process (GO:0006534)3.57860450
34glycine metabolic process (GO:0006544)3.52312405
35DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.48277787
36serine family amino acid catabolic process (GO:0009071)3.47881935
37regulation of histone H3-K9 methylation (GO:0051570)3.44141728
38folic acid-containing compound biosynthetic process (GO:0009396)3.41074363
39urea cycle (GO:0000050)3.40214184
40urea metabolic process (GO:0019627)3.40214184
41low-density lipoprotein particle clearance (GO:0034383)3.39512232
42nuclear pore organization (GO:0006999)3.38932163
43negative regulation of fatty acid biosynthetic process (GO:0045717)3.37582286
44dicarboxylic acid biosynthetic process (GO:0043650)3.35074993
45cardiac muscle adaptation (GO:0014887)3.34989623
46cardiac muscle hypertrophy in response to stress (GO:0014898)3.34989623
47muscle hypertrophy in response to stress (GO:0003299)3.34989623
48negative regulation of fibrinolysis (GO:0051918)3.34884065
49L-phenylalanine metabolic process (GO:0006558)3.34175855
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.34175855
51regulation of cholesterol homeostasis (GO:2000188)3.33157703
52histone lysine demethylation (GO:0070076)3.26570774
53heterochromatin organization (GO:0070828)3.25870234
542-oxoglutarate metabolic process (GO:0006103)3.24240826
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.22396144
56L-phenylalanine catabolic process (GO:0006559)3.22396144
57fatty acid homeostasis (GO:0055089)3.21702467
58cardiac muscle hypertrophy (GO:0003300)3.19732279
59nucleosome assembly (GO:0006334)3.19085826
60negative regulation of peptidyl-lysine acetylation (GO:2000757)3.18881657
61positive regulation of cAMP-mediated signaling (GO:0043950)3.18865842
62positive regulation of fatty acid biosynthetic process (GO:0045723)3.18675052
63trophoblast giant cell differentiation (GO:0060707)3.15924707
64fatty acid transmembrane transport (GO:1902001)3.15145750
65histone H3-K36 demethylation (GO:0070544)3.13564055
66regulation of centrosome cycle (GO:0046605)3.13252712
67carnitine shuttle (GO:0006853)3.12322402
68sulfur amino acid catabolic process (GO:0000098)3.11441549
69positive regulation of fatty acid oxidation (GO:0046321)3.11318970
70sister chromatid segregation (GO:0000819)3.11085101
71triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.09690497
72positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.09360604
73adrenergic receptor signaling pathway (GO:0071875)3.08465921
74L-alpha-amino acid transmembrane transport (GO:1902475)3.08061425
75DNA damage response, signal transduction resulting in transcription (GO:0042772)3.06448840
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06056708
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06056708
78positive regulation of mitotic sister chromatid separation (GO:1901970)3.06056708
79somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04469553
80somatic hypermutation of immunoglobulin genes (GO:0016446)3.04469553
81tachykinin receptor signaling pathway (GO:0007217)3.04077385
82histone demethylation (GO:0016577)3.03422661
83homocysteine metabolic process (GO:0050667)3.03297390
84hematopoietic stem cell proliferation (GO:0071425)3.02788503
85positive regulation of muscle hypertrophy (GO:0014742)3.01955524
86positive regulation of cardiac muscle hypertrophy (GO:0010613)3.01955524
87paraxial mesoderm development (GO:0048339)3.01570488
88transcription elongation from RNA polymerase I promoter (GO:0006362)3.00989540
89regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.99986424
90mucosal immune response (GO:0002385)2.98303117
91molting cycle (GO:0042303)2.97968992
92hair cycle (GO:0042633)2.97968992
93striated muscle hypertrophy (GO:0014897)2.97098326
94one-carbon metabolic process (GO:0006730)2.96526206
95fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.95945626
96serine family amino acid metabolic process (GO:0009069)2.94872110
97mitotic sister chromatid segregation (GO:0000070)2.94612529
98replication fork processing (GO:0031297)2.94341445
99nitrogen cycle metabolic process (GO:0071941)2.92976906
100regulation of centriole replication (GO:0046599)2.92230790
101valine metabolic process (GO:0006573)2.91906420
102insulin-like growth factor receptor signaling pathway (GO:0048009)2.91445983
103complement activation, alternative pathway (GO:0006957)2.90085554
104folic acid metabolic process (GO:0046655)2.90068472
105embryonic camera-type eye morphogenesis (GO:0048596)2.89511691
106positive regulation of histone deacetylation (GO:0031065)2.87876108
107amino-acid betaine metabolic process (GO:0006577)2.87712504
108NLS-bearing protein import into nucleus (GO:0006607)2.86600412
109regulation of fibrinolysis (GO:0051917)2.85783800
110kynurenine metabolic process (GO:0070189)2.85750941
111labyrinthine layer development (GO:0060711)2.83885915
112protein K48-linked deubiquitination (GO:0071108)2.83762240
113regulation of protein activation cascade (GO:2000257)2.82874620
114response to UV-C (GO:0010225)2.82581329
115peptidyl-glutamic acid carboxylation (GO:0017187)2.80873121
116protein carboxylation (GO:0018214)2.80873121
117peptidyl-lysine dimethylation (GO:0018027)2.79739237
118macroautophagy (GO:0016236)2.79541823
119positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.79425031
120nucleosome organization (GO:0034728)2.78364741
121regulation of fatty acid oxidation (GO:0046320)2.77200075
122negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.76745635
123positive regulation of SMAD protein import into nucleus (GO:0060391)2.76701287
124hippo signaling (GO:0035329)2.76070421
125positive regulation of protein import into nucleus, translocation (GO:0033160)2.75970467
126mitotic chromosome condensation (GO:0007076)2.75828137
127acetyl-CoA metabolic process (GO:0006084)2.75791686
128organ or tissue specific immune response (GO:0002251)2.75623759
129regulation of chromatin binding (GO:0035561)2.75315773
130positive regulation of DNA-templated transcription, initiation (GO:2000144)2.74965311
131glyoxylate metabolic process (GO:0046487)2.74792034
132negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.74183440
133adult heart development (GO:0007512)2.73019989
134epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.72771061
135chromatin assembly (GO:0031497)2.72023979
136negative regulation of histone methylation (GO:0031061)2.71903127
137embryonic retina morphogenesis in camera-type eye (GO:0060059)2.71536403
138cytoplasmic mRNA processing body assembly (GO:0033962)2.69819679
139morphogenesis of an epithelial sheet (GO:0002011)2.69484541
140regulation of cholesterol storage (GO:0010885)2.69108622
141protein-DNA complex assembly (GO:0065004)2.68850076
142regulation of histone H3-K27 methylation (GO:0061085)2.68381497
143glutamate metabolic process (GO:0006536)2.67953702
144biotin metabolic process (GO:0006768)2.67708922
145regulation of hippo signaling (GO:0035330)2.67202296
146cellular modified amino acid catabolic process (GO:0042219)2.67068855
147serine family amino acid biosynthetic process (GO:0009070)2.66895967
148regulation of complement activation (GO:0030449)2.66776584
149plasma lipoprotein particle clearance (GO:0034381)2.66528773
150positive regulation of lipid catabolic process (GO:0050996)2.65562302
151negative regulation of cholesterol transport (GO:0032375)2.64792248
152negative regulation of sterol transport (GO:0032372)2.64792248
153pore complex assembly (GO:0046931)2.64716113
154aspartate family amino acid catabolic process (GO:0009068)2.64660215
1554-hydroxyproline metabolic process (GO:0019471)2.64149771
156maternal placenta development (GO:0001893)2.63239997
157phospholipid homeostasis (GO:0055091)2.63046235
158negative regulation of fatty acid metabolic process (GO:0045922)2.62609285
159tetrahydrofolate metabolic process (GO:0046653)2.62232033
160aromatic amino acid family catabolic process (GO:0009074)2.61311138
161dorsal/ventral axis specification (GO:0009950)2.61260621
162cell proliferation in forebrain (GO:0021846)2.60723572
163mRNA stabilization (GO:0048255)2.60477015
164RNA stabilization (GO:0043489)2.60477015
165regulation of triglyceride catabolic process (GO:0010896)2.59719572
166protein demethylation (GO:0006482)2.59588275
167protein dealkylation (GO:0008214)2.59588275
168positive regulation of RNA splicing (GO:0033120)2.59579008
169triglyceride homeostasis (GO:0070328)2.59349637
170acylglycerol homeostasis (GO:0055090)2.59349637
171regulation of posttranscriptional gene silencing (GO:0060147)2.59155736
172regulation of gene silencing by miRNA (GO:0060964)2.59155736
173regulation of gene silencing by RNA (GO:0060966)2.59155736
174positive regulation of icosanoid secretion (GO:0032305)2.58655070
175epithelial cell differentiation involved in prostate gland development (GO:0060742)2.58467672
176protein K11-linked deubiquitination (GO:0035871)2.58168901
177regulation of germinal center formation (GO:0002634)2.57030036
178establishment of apical/basal cell polarity (GO:0035089)2.56922624
179midgut development (GO:0007494)2.56850975
180definitive hemopoiesis (GO:0060216)2.56555981
181post-anal tail morphogenesis (GO:0036342)2.56450113
182alpha-amino acid catabolic process (GO:1901606)2.55323848
183mitotic sister chromatid cohesion (GO:0007064)2.54624269
184positive regulation of triglyceride biosynthetic process (GO:0010867)2.54486515
185muscle hypertrophy (GO:0014896)2.54249283
186regulation of RNA export from nucleus (GO:0046831)2.53369545
187negative regulation of cell size (GO:0045792)2.53177207
188DNA integration (GO:0015074)2.52439420
189protein localization to chromosome, centromeric region (GO:0071459)2.51477293
190negative regulation of protein acetylation (GO:1901984)2.51285124
191regulation of gene silencing (GO:0060968)2.50221873
192high-density lipoprotein particle remodeling (GO:0034375)2.47999837
193regulation of sequestering of triglyceride (GO:0010889)2.44002742
194positive regulation of triglyceride metabolic process (GO:0090208)2.42833168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.79787269
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.09903392
3E2F7_22180533_ChIP-Seq_HELA_Human4.87979209
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.72327032
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.62419307
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.47220892
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.41637176
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.41327715
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.00070456
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84610194
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.41015143
12CLOCK_20551151_ChIP-Seq_293T_Human2.29512280
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27265582
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.15944455
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.12424631
16ZNF263_19887448_ChIP-Seq_K562_Human2.09161427
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.07104762
18TP53_16413492_ChIP-PET_HCT116_Human2.04209014
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03110305
20MYC_22102868_ChIP-Seq_BL_Human2.01115566
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.96261631
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.95694554
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95237466
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95190854
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.89354565
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87236630
27GATA1_22025678_ChIP-Seq_K562_Human1.79323572
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.77935884
29AR_21909140_ChIP-Seq_LNCAP_Human1.73386739
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.72579382
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.72579382
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.72579382
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70313120
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68902338
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.60222668
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59740306
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55253948
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55011070
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52174294
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51923938
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50868802
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50696359
43TCF7_22412390_ChIP-Seq_EML_Mouse1.47903973
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47782962
45KDM2B_26808549_Chip-Seq_DND41_Human1.46753564
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46100914
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45781945
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44771641
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43610107
50DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43570317
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43540087
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42079417
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37722078
54GBX2_23144817_ChIP-Seq_PC3_Human1.36901898
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36768041
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36355330
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33369660
58* ATF3_27146783_Chip-Seq_COLON_Human1.33105691
59NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31885489
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31493547
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31383454
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31108265
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30858574
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.30813492
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30025437
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29611643
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29343207
68CREB1_26743006_Chip-Seq_LNCaP_Human1.28269589
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28102518
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.25905169
71GATA1_19941826_ChIP-Seq_K562_Human1.25436088
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.25294615
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.24613513
74TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22051044
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21378719
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21279529
77* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21270981
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.20844727
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20303332
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.20041762
81FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.19537017
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19193773
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18672977
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17912656
85NCOR1_26117541_ChIP-Seq_K562_Human1.17796188
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17131174
87KDM2B_26808549_Chip-Seq_K562_Human1.16830899
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14887187
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14402673
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14034868
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13892873
92RACK7_27058665_Chip-Seq_MCF-7_Human1.13703419
93IRF1_19129219_ChIP-ChIP_H3396_Human1.13655257
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.13204643
95FUS_26573619_Chip-Seq_HEK293_Human1.12556426
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11800731
97CHD1_26751641_Chip-Seq_LNCaP_Human1.11410537
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11173754
99ELK1_19687146_ChIP-ChIP_HELA_Human1.09903385
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09559189
101EZH2_22144423_ChIP-Seq_EOC_Human1.09325074
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08650827
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07819145
104AR_21572438_ChIP-Seq_LNCaP_Human1.07753855
105NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07367197
106FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07326345
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06934723
108EWS_26573619_Chip-Seq_HEK293_Human1.06152430
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05030899
110CIITA_25753668_ChIP-Seq_RAJI_Human1.04684940
111KDM2B_26808549_Chip-Seq_JURKAT_Human1.04391657
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03869221
113MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03436292
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03371294
115MYC_18555785_ChIP-Seq_MESCs_Mouse1.02857929
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01870731
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01308103
118KDM5A_27292631_Chip-Seq_BREAST_Human1.00937579
119NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99662885
120SCL_19346495_ChIP-Seq_HPC-7_Human0.99400181
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.99191764
122STAT3_23295773_ChIP-Seq_U87_Human0.99012434
123HNF4A_19822575_ChIP-Seq_HepG2_Human0.98348761
124LXR_22292898_ChIP-Seq_THP-1_Human0.98100223
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98007628
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97957281
127TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97547431
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96420942
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96180691
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.94460047
131ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92929935
132* AHR_22903824_ChIP-Seq_MCF-7_Human0.92541997
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91457145
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90528975
135FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89562607
136* ARNT_22903824_ChIP-Seq_MCF-7_Human0.85293130
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.84534494
138TAF15_26573619_Chip-Seq_HEK293_Human0.84321945
139VDR_24787735_ChIP-Seq_THP-1_Human0.83492544
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.80783558
141MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.80602373
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79300504
143* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78419239
144* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77650520
145SOX9_26525672_Chip-Seq_HEART_Mouse0.76688379
146GATA2_19941826_ChIP-Seq_K562_Human0.75414706
147ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75086142
148RBPJ_22232070_ChIP-Seq_NCS_Mouse0.71850882
149SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71723783
150MYB_21317192_ChIP-Seq_ERMYB_Mouse0.70853319
151CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.70213819
152PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70077840
153STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.69651906
154HOXB4_20404135_ChIP-ChIP_EML_Mouse0.68494569
155* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.67461148
156ER_23166858_ChIP-Seq_MCF-7_Human0.67275278
157GF1B_26923725_Chip-Seq_HPCs_Mouse0.67202633
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.66493153
159FLI1_21867929_ChIP-Seq_TH2_Mouse0.65920655
160VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.65686277
161MYB_26560356_Chip-Seq_TH1_Human0.64346646
162GATA6_25053715_ChIP-Seq_YYC3_Human0.63388980
163VDR_21846776_ChIP-Seq_THP-1_Human0.63184951
164LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.62571060
165OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.62496787
166SMAD4_21799915_ChIP-Seq_A2780_Human0.60753799
167SMAD3_21741376_ChIP-Seq_EPCs_Human0.60457366
168CTNNB1_20460455_ChIP-Seq_HCT116_Human0.60229938
169GF1_26923725_Chip-Seq_HPCs_Mouse0.60035821
170TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.59932956
171PU_27001747_Chip-Seq_BMDM_Mouse0.59827712
172* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.59521133
173PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.59218650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.81128928
2MP0003705_abnormal_hypodermis_morpholog4.40762116
3MP0002139_abnormal_hepatobiliary_system3.58432044
4MP0002009_preneoplasia3.49118021
5MP0005360_urolithiasis3.25551329
6MP0005365_abnormal_bile_salt3.16053427
7MP0003693_abnormal_embryo_hatching2.85987722
8MP0005085_abnormal_gallbladder_physiolo2.84774585
9MP0002163_abnormal_gland_morphology2.80954552
10MP0003183_abnormal_peptide_metabolism2.76485391
11MP0005670_abnormal_white_adipose2.70225609
12MP0003252_abnormal_bile_duct2.50908578
13MP0010329_abnormal_lipoprotein_level2.27263141
14MP0004185_abnormal_adipocyte_glucose2.18603837
15MP0005171_absent_coat_pigmentation2.15765664
16MP0009697_abnormal_copulation2.15679740
17MP0005666_abnormal_adipose_tissue2.14663826
18MP0010352_gastrointestinal_tract_polyps2.09699839
19MP0003806_abnormal_nucleotide_metabolis2.01266205
20MP0005076_abnormal_cell_differentiation1.97732257
21MP0003123_paternal_imprinting1.97266903
22MP0002138_abnormal_hepatobiliary_system1.97146916
23MP0004130_abnormal_muscle_cell1.86381677
24MP0005379_endocrine/exocrine_gland_phen1.84011995
25MP0010307_abnormal_tumor_latency1.81648746
26MP0005083_abnormal_biliary_tract1.80385307
27MP0002089_abnormal_postnatal_growth/wei1.78610192
28MP0008872_abnormal_physiological_respon1.76697201
29MP0003283_abnormal_digestive_organ1.70713401
30MP0009840_abnormal_foam_cell1.67368463
31MP0004134_abnormal_chest_morphology1.66616279
32MP0010234_abnormal_vibrissa_follicle1.64104427
33MP0000372_irregular_coat_pigmentation1.63146902
34MP0005375_adipose_tissue_phenotype1.57976753
35MP0003111_abnormal_nucleus_morphology1.55570749
36MP0005220_abnormal_exocrine_pancreas1.55145569
37MP0009672_abnormal_birth_weight1.53229524
38MP0008438_abnormal_cutaneous_collagen1.52995031
39MP0004197_abnormal_fetal_growth/weight/1.52898593
40MP0008875_abnormal_xenobiotic_pharmacok1.51224070
41MP0000569_abnormal_digit_pigmentation1.50921938
42MP0001730_embryonic_growth_arrest1.47585279
43MP0000609_abnormal_liver_physiology1.46614086
44MP0002396_abnormal_hematopoietic_system1.43951939
45MP0009053_abnormal_anal_canal1.43008684
46MP0003959_abnormal_lean_body1.42197877
47MP0005409_darkened_coat_color1.42189840
48MP0002269_muscular_atrophy1.40322511
49MP0008961_abnormal_basal_metabolism1.39085343
50MP0002088_abnormal_embryonic_growth/wei1.38273679
51MP0005380_embryogenesis_phenotype1.37900946
52MP0001672_abnormal_embryogenesis/_devel1.37900946
53MP0000383_abnormal_hair_follicle1.36711177
54MP0003984_embryonic_growth_retardation1.36384846
55MP0002084_abnormal_developmental_patter1.35597332
56MP0010368_abnormal_lymphatic_system1.34348043
57MP0003566_abnormal_cell_adhesion1.33607886
58MP0002086_abnormal_extraembryonic_tissu1.33361826
59MP0004233_abnormal_muscle_weight1.32385565
60MP0002160_abnormal_reproductive_system1.31446634
61MP0002653_abnormal_ependyma_morphology1.30667012
62MP0002166_altered_tumor_susceptibility1.29978378
63MP0009703_decreased_birth_body1.27957197
64MP0000537_abnormal_urethra_morphology1.27251894
65MP0003191_abnormal_cellular_cholesterol1.26952501
66MP0001849_ear_inflammation1.24030529
67MP0003937_abnormal_limbs/digits/tail_de1.23482028
68MP0000613_abnormal_salivary_gland1.22299827
69MP0000003_abnormal_adipose_tissue1.21032513
70MP0002118_abnormal_lipid_homeostasis1.20553833
71MP0002877_abnormal_melanocyte_morpholog1.20037164
72MP0004808_abnormal_hematopoietic_stem1.19826616
73MP0008007_abnormal_cellular_replicative1.19401124
74MP0000733_abnormal_muscle_development1.18059864
75MP0001697_abnormal_embryo_size1.17990770
76MP0003890_abnormal_embryonic-extraembry1.17786417
77MP0002085_abnormal_embryonic_tissue1.13721247
78MP0003656_abnormal_erythrocyte_physiolo1.13518589
79MP0005623_abnormal_meninges_morphology1.12644698
80MP0004084_abnormal_cardiac_muscle1.12564214
81MP0004510_myositis1.11709363
82MP0010630_abnormal_cardiac_muscle1.10935620
83MP0001915_intracranial_hemorrhage1.10712588
84MP0004087_abnormal_muscle_fiber1.09381403
85MP0003221_abnormal_cardiomyocyte_apopto1.08550376
86MP0010030_abnormal_orbit_morphology1.05940267
87MP0005023_abnormal_wound_healing1.04530291
88MP0000350_abnormal_cell_proliferation1.03794975
89MP0002006_tumorigenesis1.03371594
90MP0002697_abnormal_eye_size1.03306792
91MP0003567_abnormal_fetal_cardiomyocyte1.03164920
92MP0002971_abnormal_brown_adipose1.03074873
93MP0004272_abnormal_basement_membrane1.02890425
94MP0009764_decreased_sensitivity_to1.02703004
95MP0000313_abnormal_cell_death1.01306387
96MP0002092_abnormal_eye_morphology1.00598079
97MP0003119_abnormal_digestive_system1.00424971
98MP0002075_abnormal_coat/hair_pigmentati1.00165301
99MP0002080_prenatal_lethality1.00126146
100MP0009250_abnormal_appendicular_skeleto0.99754867
101MP0005332_abnormal_amino_acid0.99682203
102MP0000428_abnormal_craniofacial_morphol0.98838782
103MP0008058_abnormal_DNA_repair0.97818330
104MP0010094_abnormal_chromosome_stability0.96301176
105MP0000747_muscle_weakness0.96236666
106MP0000598_abnormal_liver_morphology0.96060773
107MP0005647_abnormal_sex_gland0.95806989
108MP0003077_abnormal_cell_cycle0.95475858
109MP0005451_abnormal_body_composition0.95225222
110MP0005187_abnormal_penis_morphology0.94226297
111MP0002970_abnormal_white_adipose0.94144994
112MP0003115_abnormal_respiratory_system0.93932723
113MP0000358_abnormal_cell_content/0.92510107
114MP0000266_abnormal_heart_morphology0.91570121
115MP0008775_abnormal_heart_ventricle0.90951466
116MP0005334_abnormal_fat_pad0.90537554
117MP0010678_abnormal_skin_adnexa0.89510989
118MP0000749_muscle_degeneration0.89480900
119MP0002925_abnormal_cardiovascular_devel0.87374819
120MP0005389_reproductive_system_phenotype0.86629858
121MP0003646_muscle_fatigue0.86340099
122MP0009115_abnormal_fat_cell0.86244856
123MP0005319_abnormal_enzyme/_coenzyme0.86093404
124MP0003121_genomic_imprinting0.84947985
125MP0004036_abnormal_muscle_relaxation0.81306575
126MP0005257_abnormal_intraocular_pressure0.80996916
127MP0008770_decreased_survivor_rate0.79779217
128MP0001661_extended_life_span0.79496448
129MP0002111_abnormal_tail_morphology0.77755450
130MP0001293_anophthalmia0.76017036
131MP0000759_abnormal_skeletal_muscle0.74454294
132MP0003935_abnormal_craniofacial_develop0.73246213
133MP0002108_abnormal_muscle_morphology0.72033256
134MP0002735_abnormal_chemical_nociception0.72029255
135MP0001216_abnormal_epidermal_layer0.71754166
136MP0004264_abnormal_extraembryonic_tissu0.71312261
137MP0004957_abnormal_blastocyst_morpholog0.71261856
138MP0005330_cardiomyopathy0.71120005
139MP0000534_abnormal_ureter_morphology0.70980186
140MP0003195_calcinosis0.70247028
141MP0003868_abnormal_feces_composition0.69930094
142MP0002837_dystrophic_cardiac_calcinosis0.69409643
143MP0000371_diluted_coat_color0.66102446
144MP0002928_abnormal_bile_duct0.65826653
145MP0003942_abnormal_urinary_system0.65760467
146MP0001286_abnormal_eye_development0.63923530
147MP0002090_abnormal_vision0.63094176
148MP0002114_abnormal_axial_skeleton0.63004099
149MP0005384_cellular_phenotype0.62387020
150MP0001784_abnormal_fluid_regulation0.62104642

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)4.98638046
2Deformed sella turcica (HP:0002681)4.45287546
3Neoplasm of the heart (HP:0100544)4.37717362
4Medulloblastoma (HP:0002885)4.23777039
5Deep venous thrombosis (HP:0002625)4.00814255
6Diastasis recti (HP:0001540)3.87004448
7Abnormality of the parietal bone (HP:0002696)3.82232824
8Vertebral arch anomaly (HP:0008438)3.79911210
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78727529
10Anomalous pulmonary venous return (HP:0010772)3.63477717
11Broad ribs (HP:0000885)3.61881396
12Short phalanx of the thumb (HP:0009660)3.61666060
13Abnormality of the sella turcica (HP:0002679)3.57305440
14Chromsome breakage (HP:0040012)3.41357087
15Flat acetabular roof (HP:0003180)3.37961617
16Ependymoma (HP:0002888)3.30718325
17Abnormality of the pulmonary veins (HP:0011718)3.23412069
18Abnormality of the lumbar spine (HP:0100712)3.15501758
19Cerebral aneurysm (HP:0004944)3.12085553
20Intrahepatic cholestasis (HP:0001406)3.08943606
21Xanthomatosis (HP:0000991)3.03671620
22Carpal bone hypoplasia (HP:0001498)2.95681750
23Astrocytoma (HP:0009592)2.95330277
24Abnormality of the astrocytes (HP:0100707)2.95330277
25Complement deficiency (HP:0004431)2.88730610
26Abnormality of monocarboxylic acid metabolism (HP:0010996)2.88486967
27Thoracolumbar scoliosis (HP:0002944)2.87239703
28Turricephaly (HP:0000262)2.80164180
29Abnormality of chromosome stability (HP:0003220)2.76920625
30Hyperlipoproteinemia (HP:0010980)2.76557453
31Heterotopia (HP:0002282)2.76175381
32Spastic diplegia (HP:0001264)2.74493893
33Calf muscle hypertrophy (HP:0008981)2.72434457
34Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.72236559
35Reticulocytosis (HP:0001923)2.71125427
36Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.70835530
37Hyperacusis (HP:0010780)2.68726183
38Hypoalphalipoproteinemia (HP:0003233)2.68430689
39Abnormality of the distal phalanx of the thumb (HP:0009617)2.68000087
40Abnormality of the lower motor neuron (HP:0002366)2.66990555
41Hyperglycinemia (HP:0002154)2.66258095
42Renovascular hypertension (HP:0100817)2.63282094
43Hypoplasia of the pons (HP:0012110)2.62143616
44Epidermoid cyst (HP:0200040)2.61136651
45Down-sloping shoulders (HP:0200021)2.56645611
46Supernumerary ribs (HP:0005815)2.54322883
47Rough bone trabeculation (HP:0100670)2.53030425
48Vertebral fusion (HP:0002948)2.52875203
49Ketosis (HP:0001946)2.51475577
50Prominent nose (HP:0000448)2.51394782
51Hamartoma (HP:0010566)2.50243215
52Hypobetalipoproteinemia (HP:0003563)2.46716926
53Pseudobulbar signs (HP:0002200)2.44930947
54Abnormality of glycine metabolism (HP:0010895)2.44671499
55Abnormality of serine family amino acid metabolism (HP:0010894)2.44671499
56Muscle hypertrophy of the lower extremities (HP:0008968)2.44606795
57Thickened calvaria (HP:0002684)2.43783118
58Hypolipoproteinemia (HP:0010981)2.43727234
59Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.43488932
60Back pain (HP:0003418)2.43044186
61Elfin facies (HP:0004428)2.42426610
62Shallow orbits (HP:0000586)2.42238381
63Hypoplastic pelvis (HP:0008839)2.41320959
64Premature graying of hair (HP:0002216)2.40338273
65Hemivertebrae (HP:0002937)2.38055390
66Abnormality of the pons (HP:0007361)2.37364918
67Abnormality of the odontoid process (HP:0003310)2.36140291
68Difficulty running (HP:0009046)2.35266639
69Skin pits (HP:0100276)2.34841671
70Renal duplication (HP:0000075)2.34388568
71Abnormality of DNA repair (HP:0003254)2.32598696
72Hyperglycinuria (HP:0003108)2.31733740
73Hand muscle atrophy (HP:0009130)2.31468133
74Supernumerary bones of the axial skeleton (HP:0009144)2.31119387
75Slow saccadic eye movements (HP:0000514)2.30783217
76Macroorchidism (HP:0000053)2.30210898
77Cerebellar dysplasia (HP:0007033)2.28796494
78Skin nodule (HP:0200036)2.28266789
79Abnormality of the preputium (HP:0100587)2.27000306
80Abnormality of sulfur amino acid metabolism (HP:0004339)2.25548943
81Mitral valve prolapse (HP:0001634)2.24963917
82Nephroblastoma (Wilms tumor) (HP:0002667)2.24735393
83Hypoglycemic coma (HP:0001325)2.24460493
84Acute myeloid leukemia (HP:0004808)2.24406172
85Wide intermamillary distance (HP:0006610)2.23890985
86Hyperammonemia (HP:0001987)2.23527782
87Myoglobinuria (HP:0002913)2.23255938
88Upper limb amyotrophy (HP:0009129)2.23009618
89Distal upper limb amyotrophy (HP:0007149)2.23009618
90Thoracic kyphosis (HP:0002942)2.22383089
91Hyporeflexia of lower limbs (HP:0002600)2.21130896
92Glioma (HP:0009733)2.20948028
93Aneurysm (HP:0002617)2.20584425
94Protrusio acetabuli (HP:0003179)2.19485391
95Lymphangioma (HP:0100764)2.17813059
96Death in childhood (HP:0003819)2.17581391
97Embryonal renal neoplasm (HP:0011794)2.16454246
98Poikilocytosis (HP:0004447)2.15824348
99Broad alveolar ridges (HP:0000187)2.15773136
100Abnormality of aromatic amino acid family metabolism (HP:0004338)2.14507839
101Aplasia/Hypoplasia of the uvula (HP:0010293)2.13975027
102Abnormality of the Achilles tendon (HP:0005109)2.13811712
103Abnormal hand bone ossification (HP:0010660)2.13417190
104Short femoral neck (HP:0100864)2.11651872
105Genetic anticipation (HP:0003743)2.07782386
106Papillary thyroid carcinoma (HP:0002895)2.06898489
107Abnormality of the carotid arteries (HP:0005344)2.06736560
108Hypercholesterolemia (HP:0003124)2.06056550
109Increased connective tissue (HP:0009025)2.06036214
110Enlarged penis (HP:0000040)2.05928583
111Bowel diverticulosis (HP:0005222)2.05171270
112Abnormality of the 4th metacarpal (HP:0010012)2.04345218
113Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02937670
114Short 4th metacarpal (HP:0010044)2.02937670
115Abnormality of complement system (HP:0005339)2.02438991
116Aortic regurgitation (HP:0001659)2.02329267
117Global brain atrophy (HP:0002283)2.01920491
118Hemiplegia (HP:0002301)2.01632871
119Insomnia (HP:0100785)2.00537518
120Myocardial infarction (HP:0001658)2.00289402
121Hepatocellular carcinoma (HP:0001402)1.99758254
122Cortical dysplasia (HP:0002539)1.98275020
123Abnormal trabecular bone morphology (HP:0100671)1.97566370
124Meningioma (HP:0002858)1.97487489
125Abnormality of the thoracic spine (HP:0100711)1.93185165
126Hypoplastic iliac wings (HP:0002866)1.93067175
127Abnormal ossification of hand bones (HP:0005921)1.92824792
128Hypopigmentation of the fundus (HP:0007894)1.91621756
129Basal cell carcinoma (HP:0002671)1.91505458
130Curly hair (HP:0002212)1.91452123
131Dysmetric saccades (HP:0000641)1.91092853
132Hyperglycemia (HP:0003074)1.91074730
133Urethral obstruction (HP:0000796)1.90233020
134Ankle contracture (HP:0006466)1.90230619
135Achilles tendon contracture (HP:0001771)1.89855382
136Ectopic kidney (HP:0000086)1.89247662
137Meckel diverticulum (HP:0002245)1.88553130
138Abnormality of the wing of the ilium (HP:0011867)1.88295093
139Pathologic fracture (HP:0002756)1.87077127
140Difficulty climbing stairs (HP:0003551)1.87060268
141Hypochromic microcytic anemia (HP:0004840)1.86309388
142Abnormality of the diencephalon (HP:0010662)1.85240055
143Abnormality of the left ventricular outflow tract (HP:0011103)1.84819501
144Subaortic stenosis (HP:0001682)1.84819501
145Abnormality of the ileum (HP:0001549)1.84254357
146Skull defect (HP:0001362)1.84202040
147Cholelithiasis (HP:0001081)1.83870550
148Cafe-au-lait spot (HP:0000957)1.83232197
149Neoplasm of the oral cavity (HP:0100649)1.82730201
150Esophageal varix (HP:0002040)1.82407004
151Short thumb (HP:0009778)1.82275678
152Ketoacidosis (HP:0001993)1.81710013
153Exercise-induced muscle cramps (HP:0003710)1.80765124
154Abnormality of the epiphyses of the hand (HP:0005924)1.80353095
155Neoplasm of striated muscle (HP:0009728)1.79822892
156Polycythemia (HP:0001901)1.79582395
157Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.79239514
158J-shaped sella turcica (HP:0002680)1.77886529
159Hyperinsulinemic hypoglycemia (HP:0000825)1.76437255
160Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.76027741
161Resting tremor (HP:0002322)1.75947599
162Hamartoma of the eye (HP:0010568)1.75783918
163Myelomeningocele (HP:0002475)1.75556431
164Abnormality of chromosome segregation (HP:0002916)1.75192926
165Sparse lateral eyebrow (HP:0005338)1.74897854
166Overriding aorta (HP:0002623)1.74743797
167Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.74592553
168Cellular immunodeficiency (HP:0005374)1.74416332
169Squamous cell carcinoma (HP:0002860)1.74095777
170Rhabdomyolysis (HP:0003201)1.73202111
171Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.72962875
172Poikiloderma (HP:0001029)1.72675636
173Fibroma (HP:0010614)1.72175657
174Sloping forehead (HP:0000340)1.72128991
175Subacute progressive viral hepatitis (HP:0006572)1.71886336
176Menstrual irregularities (HP:0000858)1.71194927
177Status epilepticus (HP:0002133)1.70520209
178Milia (HP:0001056)1.69606578
179Long toe (HP:0010511)1.68801443
180Bladder diverticulum (HP:0000015)1.67797376
181Fibrous tissue neoplasm (HP:0012316)1.65686147
182EMG: neuropathic changes (HP:0003445)1.65492314
183Broad metatarsal (HP:0001783)1.65141430
184Abnormality of pyrimidine metabolism (HP:0004353)1.64895542
185Aortic aneurysm (HP:0004942)1.64682166
186Increased nuchal translucency (HP:0010880)1.62544674
187Ulnar bowing (HP:0003031)1.61985030
188Subcapsular cataract (HP:0000523)1.61671182
189Malignant gastrointestinal tract tumors (HP:0006749)1.60717637
190Gastrointestinal carcinoma (HP:0002672)1.60717637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K76.08132561
2CDK124.04314765
3TRIB33.94599913
4PKN23.93608537
5ZAK3.72785147
6TLK13.43651055
7BLK2.81581025
8LATS12.81391138
9EEF2K2.61728783
10MAP3K102.57977309
11CAMK1D2.55857464
12SIK12.39187222
13TTN2.11113790
14CAMK1G2.05419162
15ICK2.02144488
16RIPK11.94045663
17VRK11.94016193
18CDC71.89211274
19SCYL21.86164385
20MTOR1.81763217
21NEK11.79549205
22LATS21.78941896
23PDGFRA1.78420815
24BCKDK1.76586283
25ERN11.68479753
26TAF11.60032464
27NEK91.59154123
28NEK21.50183786
29BRSK21.49623214
30PTK61.47942450
31CDK61.32564549
32CDK41.32112823
33SGK21.31122825
34PAK21.30043573
35STK31.29635603
36EIF2AK31.29399618
37BRD41.23885328
38RPS6KA51.23716558
39TTK1.22462275
40FLT31.20951236
41BMX1.13571835
42ALK1.12529903
43GRK71.05977472
44WNK11.05975240
45TGFBR21.01651111
46MAP2K31.00149162
47EPHA20.96310693
48CAMKK20.95302663
49MAP2K40.92255664
50RET0.88054328
51RPS6KB20.86574564
52PAK40.85879803
53PDK30.84554004
54PDK40.84554004
55PRKD30.83846618
56AKT30.82623087
57MELK0.82035854
58DDR20.81088654
59MET0.80278887
60PRKAA10.79516775
61MAP3K20.78830175
62CHEK20.76395893
63PIM10.75735457
64CDK70.75675964
65PLK40.75246394
66PTK20.74635586
67AURKA0.73986297
68FGFR40.73930898
69AKT20.73194342
70FGFR10.72826407
71NEK60.71534100
72TYRO30.70439806
73CHEK10.70378836
74PNCK0.70346203
75STK40.70047968
76SGK4940.68217059
77SGK2230.68217059
78WEE10.68006171
79AURKB0.67139709
80MAP3K40.66856410
81CSNK1D0.65270849
82TAOK10.65072476
83MAP3K80.65006771
84STK380.64702449
85PRKAA20.64450038
86PDGFRB0.64329595
87FRK0.63789447
88EPHA30.62738576
89CDK20.62410000
90CDK90.62010401
91DAPK30.61910551
92PHKG20.61712638
93PHKG10.61712638
94PKN10.61335058
95OBSCN0.60659174
96ERBB20.60583611
97PASK0.60018897
98ACVR1B0.59842624
99ATM0.59237425
100PAK60.59209160
101MAP3K60.58115557
102SGK30.57006805
103ATR0.56975936
104INSRR0.56289108
105MAP3K70.56134471
106MAP3K90.55868078
107EIF2AK10.54843920
108CSNK1E0.53379333
109MAPK110.51992818
110FGFR20.51463803
111EIF2AK20.50719415
112TGFBR10.50375638
113TAOK30.47383296
114DYRK1B0.46677099
115PRKDC0.46606109
116DYRK30.46161726
117ERBB40.45842422
118BMPR20.45802869
119CAMK40.45729333
120PLK10.45540330
121STK100.44854762
122CCNB10.44830147
123BMPR1B0.43875740
124GSK3A0.43853305
125RPS6KB10.43513239
126CDK10.43254229
127JAK20.42788177
128MAPK10.42616255
129IRAK10.42146032
130TNIK0.41906178
131FGFR30.40711887
132PRPF4B0.40497454
133MAP3K30.40174129
134MAPK140.39326511
135SGK10.37786196
136GSK3B0.37651877
137STK38L0.37646206
138PDK20.37358499
139IRAK30.36963632
140CDC42BPA0.36751872
141MAPK100.36246825
142CSNK1A1L0.35441628
143RPS6KA20.34847076
144DMPK0.34831555
145KSR20.33561118
146MATK0.31885790
147CLK10.30383687
148BUB10.28618963
149NLK0.28381397
150KSR10.27379590
151MKNK20.27347222
152RPS6KA40.25707765
153PRKCH0.25499582
154HIPK20.25377911
155CDK80.23560838

Predicted pathways (KEGG)

RankGene SetZ-score
1Alcoholism_Homo sapiens_hsa050345.26269115
2Nitrogen metabolism_Homo sapiens_hsa009103.73362196
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16785239
4Viral carcinogenesis_Homo sapiens_hsa052033.04071996
5Arginine biosynthesis_Homo sapiens_hsa002202.66838188
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.54612663
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43669816
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30155756
9Lysine degradation_Homo sapiens_hsa003102.24760221
10Fatty acid degradation_Homo sapiens_hsa000712.17315656
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.10217050
12PPAR signaling pathway_Homo sapiens_hsa033202.02262177
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.00868962
14One carbon pool by folate_Homo sapiens_hsa006701.91544332
15Propanoate metabolism_Homo sapiens_hsa006401.89034206
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87664777
17Vitamin B6 metabolism_Homo sapiens_hsa007501.82822781
18Fatty acid metabolism_Homo sapiens_hsa012121.82224284
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.82222741
20Biosynthesis of amino acids_Homo sapiens_hsa012301.78418029
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78174901
22Selenocompound metabolism_Homo sapiens_hsa004501.75684814
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70357063
24Complement and coagulation cascades_Homo sapiens_hsa046101.64968386
25Tryptophan metabolism_Homo sapiens_hsa003801.63810577
26Prolactin signaling pathway_Homo sapiens_hsa049171.63201883
27Carbon metabolism_Homo sapiens_hsa012001.61388581
28Fatty acid biosynthesis_Homo sapiens_hsa000611.57518178
29Fanconi anemia pathway_Homo sapiens_hsa034601.52435631
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52428184
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47783705
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43884727
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41278492
34ErbB signaling pathway_Homo sapiens_hsa040121.33098538
35Bile secretion_Homo sapiens_hsa049761.32886393
36Pancreatic cancer_Homo sapiens_hsa052121.30734386
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29668700
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.29339625
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.28578319
40ABC transporters_Homo sapiens_hsa020101.25171745
41Pyruvate metabolism_Homo sapiens_hsa006201.21196272
42mTOR signaling pathway_Homo sapiens_hsa041501.19680898
43Butanoate metabolism_Homo sapiens_hsa006501.19556863
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17474694
45AMPK signaling pathway_Homo sapiens_hsa041521.13767543
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13347348
47Insulin resistance_Homo sapiens_hsa049311.12238985
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11945321
49Dorso-ventral axis formation_Homo sapiens_hsa043201.11829540
50FoxO signaling pathway_Homo sapiens_hsa040681.11124625
51Prostate cancer_Homo sapiens_hsa052151.07222279
52beta-Alanine metabolism_Homo sapiens_hsa004101.05723503
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.03172246
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.02738712
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01264493
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.98254638
57Homologous recombination_Homo sapiens_hsa034400.97436324
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.96651431
59Glioma_Homo sapiens_hsa052140.96648672
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95918164
61GnRH signaling pathway_Homo sapiens_hsa049120.95870232
62Glucagon signaling pathway_Homo sapiens_hsa049220.95704296
63Hepatitis B_Homo sapiens_hsa051610.95432327
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95223359
65B cell receptor signaling pathway_Homo sapiens_hsa046620.95155926
66Starch and sucrose metabolism_Homo sapiens_hsa005000.95033217
67Insulin signaling pathway_Homo sapiens_hsa049100.94337467
68T cell receptor signaling pathway_Homo sapiens_hsa046600.94157225
69Fat digestion and absorption_Homo sapiens_hsa049750.94082970
70Melanoma_Homo sapiens_hsa052180.92562572
71Caffeine metabolism_Homo sapiens_hsa002320.92232105
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90794876
73Pancreatic secretion_Homo sapiens_hsa049720.87957980
74TNF signaling pathway_Homo sapiens_hsa046680.87786649
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86474536
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86156564
77Thyroid cancer_Homo sapiens_hsa052160.85198070
78Renal cell carcinoma_Homo sapiens_hsa052110.85002976
79Peroxisome_Homo sapiens_hsa041460.84789199
80Glycerolipid metabolism_Homo sapiens_hsa005610.84145213
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84108702
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.79730943
83Choline metabolism in cancer_Homo sapiens_hsa052310.77017386
84RNA transport_Homo sapiens_hsa030130.75944530
85Basal cell carcinoma_Homo sapiens_hsa052170.74293866
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74216331
87Nucleotide excision repair_Homo sapiens_hsa034200.74146774
88Adherens junction_Homo sapiens_hsa045200.73032637
89Acute myeloid leukemia_Homo sapiens_hsa052210.72396061
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70893026
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70588794
92Phenylalanine metabolism_Homo sapiens_hsa003600.70533747
93Wnt signaling pathway_Homo sapiens_hsa043100.70061137
94Staphylococcus aureus infection_Homo sapiens_hsa051500.69865029
95Type II diabetes mellitus_Homo sapiens_hsa049300.69069620
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.68434252
97Non-homologous end-joining_Homo sapiens_hsa034500.68396318
98Basal transcription factors_Homo sapiens_hsa030220.66480625
99Chronic myeloid leukemia_Homo sapiens_hsa052200.65898523
100DNA replication_Homo sapiens_hsa030300.64765478
101Hepatitis C_Homo sapiens_hsa051600.64472575
102Pentose phosphate pathway_Homo sapiens_hsa000300.64381621
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63239532
104Circadian rhythm_Homo sapiens_hsa047100.62290085
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61818326
106Hippo signaling pathway_Homo sapiens_hsa043900.61043339
107Influenza A_Homo sapiens_hsa051640.60589758
108Inositol phosphate metabolism_Homo sapiens_hsa005620.60366577
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60245345
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58643303
111Osteoclast differentiation_Homo sapiens_hsa043800.58523301
112MAPK signaling pathway_Homo sapiens_hsa040100.58101910
113mRNA surveillance pathway_Homo sapiens_hsa030150.57409616
114Proteoglycans in cancer_Homo sapiens_hsa052050.56997365
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56993191
116Oocyte meiosis_Homo sapiens_hsa041140.56145160
117Tyrosine metabolism_Homo sapiens_hsa003500.56108509
118MicroRNAs in cancer_Homo sapiens_hsa052060.55513411
119Fructose and mannose metabolism_Homo sapiens_hsa000510.54948753
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54478864
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54058496
122Arginine and proline metabolism_Homo sapiens_hsa003300.53891158
123Chemical carcinogenesis_Homo sapiens_hsa052040.53863857
124Focal adhesion_Homo sapiens_hsa045100.52918013
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52248052
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52175370
127Sulfur relay system_Homo sapiens_hsa041220.52123227
128Thyroid hormone synthesis_Homo sapiens_hsa049180.51074390
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50791688
130Gap junction_Homo sapiens_hsa045400.50770225
131Systemic lupus erythematosus_Homo sapiens_hsa053220.49780379
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49659452
133Small cell lung cancer_Homo sapiens_hsa052220.49225793
134Retinol metabolism_Homo sapiens_hsa008300.48784495
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48782564
136Galactose metabolism_Homo sapiens_hsa000520.48584559
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48546302
138Pathways in cancer_Homo sapiens_hsa052000.48176261
139Endometrial cancer_Homo sapiens_hsa052130.46959154
140HTLV-I infection_Homo sapiens_hsa051660.46949404
141Notch signaling pathway_Homo sapiens_hsa043300.44748549
142Long-term potentiation_Homo sapiens_hsa047200.44364067
143Prion diseases_Homo sapiens_hsa050200.43841994
144p53 signaling pathway_Homo sapiens_hsa041150.43742393
145Maturity onset diabetes of the young_Homo sapiens_hsa049500.43242384
146Herpes simplex infection_Homo sapiens_hsa051680.42195495
147VEGF signaling pathway_Homo sapiens_hsa043700.41389202
148Platelet activation_Homo sapiens_hsa046110.40784076
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.39760668
150Renin secretion_Homo sapiens_hsa049240.39530883
151Apoptosis_Homo sapiens_hsa042100.39204721
152cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39139336
153Cell cycle_Homo sapiens_hsa041100.38979963
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.38826461
155ECM-receptor interaction_Homo sapiens_hsa045120.36194992
156Colorectal cancer_Homo sapiens_hsa052100.34453502
157Bladder cancer_Homo sapiens_hsa052190.34372389
158Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34251745
159Folate biosynthesis_Homo sapiens_hsa007900.33623520
160Hedgehog signaling pathway_Homo sapiens_hsa043400.32947009
161Estrogen signaling pathway_Homo sapiens_hsa049150.32817267
162TGF-beta signaling pathway_Homo sapiens_hsa043500.31654133
163Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30118496
164Non-small cell lung cancer_Homo sapiens_hsa052230.29782071

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