UHRF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.96788935
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.69562720
3monoubiquitinated protein deubiquitination (GO:0035520)4.02566791
4histone H3-K36 demethylation (GO:0070544)3.80564314
5positive regulation of granulocyte differentiation (GO:0030854)3.73526081
6definitive hemopoiesis (GO:0060216)3.70556092
7histone H3-K9 modification (GO:0061647)3.55658798
8nuclear pore complex assembly (GO:0051292)3.50045214
9mitotic sister chromatid cohesion (GO:0007064)3.49372416
10positive regulation of gamma-delta T cell activation (GO:0046645)3.46560807
11histone H3-K9 methylation (GO:0051567)3.46305573
12positive T cell selection (GO:0043368)3.45211976
13DNA unwinding involved in DNA replication (GO:0006268)3.37215385
14regulation of DNA endoreduplication (GO:0032875)3.31429624
15regulation of histone H3-K27 methylation (GO:0061085)3.31063067
16mitotic chromosome condensation (GO:0007076)3.30900772
17nuclear pore organization (GO:0006999)3.09675057
18positive regulation of mitotic sister chromatid separation (GO:1901970)3.07123213
19positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.07123213
20positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.07123213
21interkinetic nuclear migration (GO:0022027)3.05524600
22T cell selection (GO:0045058)3.05434220
23positive thymic T cell selection (GO:0045059)3.01987144
24histone lysine demethylation (GO:0070076)2.99841292
25histone demethylation (GO:0016577)2.93523673
26peptidyl-lysine methylation (GO:0018022)2.90756459
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.88128376
28negative regulation of cell killing (GO:0031342)2.88128376
29positive regulation of B cell differentiation (GO:0045579)2.86274484
30negative regulation of DNA-dependent DNA replication (GO:2000104)2.83897399
31germ cell migration (GO:0008354)2.81278534
32T cell migration (GO:0072678)2.79531206
33positive regulation of histone H3-K4 methylation (GO:0051571)2.78656601
34regulation of histone methylation (GO:0031060)2.77675776
35thymic T cell selection (GO:0045061)2.77540759
36positive regulation of DNA-templated transcription, initiation (GO:2000144)2.76917911
37negative regulation of B cell proliferation (GO:0030889)2.76317216
38histone lysine methylation (GO:0034968)2.76182875
39histone H3-K9 demethylation (GO:0033169)2.73432921
40dosage compensation (GO:0007549)2.72747350
41N-terminal protein amino acid acetylation (GO:0006474)2.72737184
42negative regulation of fibroblast apoptotic process (GO:2000270)2.70231612
43regulation of RNA export from nucleus (GO:0046831)2.69809950
44V(D)J recombination (GO:0033151)2.67056305
45histone-serine phosphorylation (GO:0035404)2.66987601
46pore complex assembly (GO:0046931)2.66286902
47B cell proliferation (GO:0042100)2.66281636
48regulation of DNA methylation (GO:0044030)2.65643236
49B cell homeostasis (GO:0001782)2.65374429
50positive regulation of histone methylation (GO:0031062)2.62645639
51negative regulation of erythrocyte differentiation (GO:0045647)2.62332165
52interferon-gamma production (GO:0032609)2.61612620
53histone H3-K4 trimethylation (GO:0080182)2.60492349
54regulation of B cell receptor signaling pathway (GO:0050855)2.59622205
55antigen processing and presentation of endogenous antigen (GO:0019883)2.58242829
56DNA topological change (GO:0006265)2.57936854
57response to muramyl dipeptide (GO:0032495)2.57543828
58sister chromatid cohesion (GO:0007062)2.56589786
59regulation of gamma-delta T cell activation (GO:0046643)2.53970068
60hypotonic response (GO:0006971)2.52285893
61protein dealkylation (GO:0008214)2.51797828
62protein demethylation (GO:0006482)2.51797828
63regulation of gamma-delta T cell differentiation (GO:0045586)2.50739032
64histone mRNA catabolic process (GO:0071044)2.48252899
65regulation of fibroblast apoptotic process (GO:2000269)2.45081754
66tolerance induction (GO:0002507)2.44557657
67DNA geometric change (GO:0032392)2.43437549
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.42905893
69positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.42124282
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.41777559
71DNA duplex unwinding (GO:0032508)2.41691372
72regulation of B cell differentiation (GO:0045577)2.39284549
73cytoplasmic mRNA processing body assembly (GO:0033962)2.38520437
74regulation of thymocyte apoptotic process (GO:0070243)2.37971801
75regulation of granulocyte differentiation (GO:0030852)2.37096985
76negative regulation of histone modification (GO:0031057)2.36013493
77nucleus organization (GO:0006997)2.35101843
78regulation of histone H3-K4 methylation (GO:0051569)2.34944531
79T cell homeostasis (GO:0043029)2.34675168
80peptidyl-lysine trimethylation (GO:0018023)2.33818296
81poly(A)+ mRNA export from nucleus (GO:0016973)2.33365472
82regulation of MHC class I biosynthetic process (GO:0045343)2.33297192
83negative regulation of DNA repair (GO:0045738)2.31263450
84embryonic process involved in female pregnancy (GO:0060136)2.31210014
85cellular extravasation (GO:0045123)2.31096355
86regulation of sister chromatid cohesion (GO:0007063)2.30843824
87alternative mRNA splicing, via spliceosome (GO:0000380)2.30495355
88positive regulation by organism of defense response of other organism involved in symbiotic interact2.30312651
89modulation by symbiont of host immune response (GO:0052553)2.30312651
90positive regulation by symbiont of host defense response (GO:0052509)2.30312651
91modulation by symbiont of host defense response (GO:0052031)2.30312651
92modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30312651
93modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.30312651
94cellular response to ethanol (GO:0071361)2.29865311
95DNA synthesis involved in DNA repair (GO:0000731)2.29610824
96antigen receptor-mediated signaling pathway (GO:0050851)2.29543234
97regulation of nucleobase-containing compound transport (GO:0032239)2.29427031
98positive regulation of developmental pigmentation (GO:0048087)2.28959731
99peptidyl-lysine dimethylation (GO:0018027)2.28913238
100histone H4-K16 acetylation (GO:0043984)2.28718672
101substrate-dependent cell migration (GO:0006929)2.27840884
102SMAD protein complex assembly (GO:0007183)2.27689375
103negative regulation of histone methylation (GO:0031061)2.26958986
104regulation of NFAT protein import into nucleus (GO:0051532)2.26826869
105negative regulation of RNA splicing (GO:0033119)2.26520610
106histone deubiquitination (GO:0016578)2.26032442
107tyrosine phosphorylation of STAT protein (GO:0007260)2.25456571
108kinetochore organization (GO:0051383)2.25135365
109histone H3-K4 methylation (GO:0051568)2.24555493
110peptidyl-threonine phosphorylation (GO:0018107)2.24453332
111negative regulation of T cell mediated immunity (GO:0002710)2.23567083
112lymphocyte homeostasis (GO:0002260)2.23203692
113translesion synthesis (GO:0019985)2.22363715
114negative regulation of chromatin modification (GO:1903309)2.22352460
115regulation of histone H3-K9 methylation (GO:0051570)2.21965251
116negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.21583980
117negative regulation of translation, ncRNA-mediated (GO:0040033)2.21583980
118regulation of translation, ncRNA-mediated (GO:0045974)2.21583980
119neural tube formation (GO:0001841)2.20913127
120embryonic hemopoiesis (GO:0035162)2.19081594
121positive regulation of defense response to virus by host (GO:0002230)2.18635767
122response to interleukin-15 (GO:0070672)2.18613756
123embryonic camera-type eye morphogenesis (GO:0048596)2.17754036
124necroptotic process (GO:0070266)2.16862440
125mRNA stabilization (GO:0048255)2.16825596
126RNA stabilization (GO:0043489)2.16825596
127negative regulation of thymocyte apoptotic process (GO:0070244)2.15743875
128positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.14704310
129neutrophil activation involved in immune response (GO:0002283)2.12660819
130B cell receptor signaling pathway (GO:0050853)2.12460779
131ribosomal small subunit assembly (GO:0000028)2.10812370
132regulation of interleukin-12 biosynthetic process (GO:0045075)2.10350872
133hepatocyte apoptotic process (GO:0097284)2.09672073
134chromatin assembly (GO:0031497)2.09650690
135negative regulation of bone resorption (GO:0045779)2.08730194
136regulation of stem cell maintenance (GO:2000036)2.08699868
137erythrocyte maturation (GO:0043249)2.07393059
138antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.07216209
139antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.07216209
140negative regulation of bone remodeling (GO:0046851)2.06146936
141negative regulation of granulocyte differentiation (GO:0030853)2.04028009
142DNA strand renaturation (GO:0000733)2.03073146
143pre-miRNA processing (GO:0031054)2.02881264
144positive regulation of interferon-alpha production (GO:0032727)2.02802691
145regulation of chromatin silencing (GO:0031935)2.02328166
146negative regulation of phagocytosis (GO:0050765)2.02214544
147phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.01532160
148CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.01374435
149T-helper cell differentiation (GO:0042093)2.01374435
150I-kappaB phosphorylation (GO:0007252)2.01107243
151T cell differentiation in thymus (GO:0033077)2.00848634
152mRNA splice site selection (GO:0006376)2.00631169
153negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.00228470
154mitotic recombination (GO:0006312)1.99764521
155alpha-beta T cell activation (GO:0046631)1.99729649
156negative T cell selection (GO:0043383)1.99359137
157regulation of nuclear cell cycle DNA replication (GO:0033262)1.98791580
158sister chromatid segregation (GO:0000819)1.98694408
159T cell differentiation (GO:0030217)1.96999472
160negative thymic T cell selection (GO:0045060)1.96791180
161necrotic cell death (GO:0070265)1.96367378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.25838636
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.87891790
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.54200693
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.69933465
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.64134150
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.61700874
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.48540171
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.33001681
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10500917
10SCL_19346495_ChIP-Seq_HPC-7_Human2.97317048
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.86383511
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.81274413
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.59805335
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.48109481
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47395564
16MYC_22102868_ChIP-Seq_BL_Human2.24836544
17GATA1_22025678_ChIP-Seq_K562_Human2.20628192
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18579613
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14800777
20* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.08512031
21* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08431003
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.07475860
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06127655
24RUNX_20019798_ChIP-Seq_JUKART_Human2.05889476
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.04257344
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02659714
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.86929899
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83817399
29* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83519745
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.82621290
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81426401
32MYB_26560356_Chip-Seq_TH2_Human1.78621573
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.75823767
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73451699
35MYB_26560356_Chip-Seq_TH1_Human1.72447519
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71134826
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67135923
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64092153
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58570773
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.55373496
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54532608
42TCF7_22412390_ChIP-Seq_EML_Mouse1.54181128
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.51393723
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.49647895
45ELK1_19687146_ChIP-ChIP_HELA_Human1.49335872
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48171442
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45604036
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41097938
49VDR_21846776_ChIP-Seq_THP-1_Human1.39339470
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36198514
51MAF_26560356_Chip-Seq_TH1_Human1.34597358
52* BRD4_25478319_ChIP-Seq_HGPS_Human1.32762545
53EWS_26573619_Chip-Seq_HEK293_Human1.32647924
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32426748
55* SPI1_23547873_ChIP-Seq_NB4_Human1.31232079
56* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29922467
57* VDR_24763502_ChIP-Seq_THP-1_Human1.29319050
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26216916
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25885912
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25135817
61* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21455390
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.21079386
63PU_27001747_Chip-Seq_BMDM_Mouse1.19290714
64* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14977053
65CIITA_25753668_ChIP-Seq_RAJI_Human1.14555010
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13253832
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12253046
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12200093
69VDR_24787735_ChIP-Seq_THP-1_Human1.11609737
70UTX_26944678_Chip-Seq_JUKART_Human1.10180663
71TP53_16413492_ChIP-PET_HCT116_Human1.08456693
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07684675
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07588063
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.07141089
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05421217
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05421217
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05421217
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03476340
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03476340
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01818069
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01731460
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00714540
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00543213
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00120133
85TFEB_21752829_ChIP-Seq_HELA_Human0.99268654
86* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98858565
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98104608
88PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97766647
89* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97462753
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97041940
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95211305
92* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94925759
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94163581
94TCF4_18268006_ChIP-ChIP_LS174T_Human0.93453466
95* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92219596
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91920036
97IGF1R_20145208_ChIP-Seq_DFB_Human0.91444473
98* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91267370
99* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90464908
100* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90433674
101AR_21572438_ChIP-Seq_LNCaP_Human0.90141719
102GATA3_27048872_Chip-Seq_THYMUS_Human0.89746255
103POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89200490
104EZH2_27294783_Chip-Seq_NPCs_Mouse0.88887053
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88347237
106KDM2B_26808549_Chip-Seq_JURKAT_Human0.88202323
107* SPI1_23127762_ChIP-Seq_K562_Human0.87305986
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.84896221
109GATA3_26560356_Chip-Seq_TH2_Human0.84849838
110RXR_22108803_ChIP-Seq_LS180_Human0.84374708
111PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84013036
112GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83874528
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83280928
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83180091
115* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82150825
116TAF15_26573619_Chip-Seq_HEK293_Human0.81890322
117AR_21909140_ChIP-Seq_LNCAP_Human0.80522439
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80409235
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.79991516
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79561969
121FUS_26573619_Chip-Seq_HEK293_Human0.78818753
122MYC_18555785_ChIP-Seq_MESCs_Mouse0.77720021
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76455050
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.76033532
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74522054
126CLOCK_20551151_ChIP-Seq_293T_Human0.73752066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.69367032
2MP0008057_abnormal_DNA_replication2.63996306
3MP0002396_abnormal_hematopoietic_system2.38151265
4MP0001835_abnormal_antigen_presentation2.35715027
5MP0004808_abnormal_hematopoietic_stem2.27491840
6MP0008007_abnormal_cellular_replicative2.05605886
7MP0002166_altered_tumor_susceptibility1.94663737
8MP0005174_abnormal_tail_pigmentation1.91440076
9MP0010094_abnormal_chromosome_stability1.87418073
10MP0003300_gastrointestinal_ulcer1.81067307
11MP0001800_abnormal_humoral_immune1.80693865
12MP0010352_gastrointestinal_tract_polyps1.76980829
13MP0001879_abnormal_lymphatic_vessel1.75886101
14MP0002006_tumorigenesis1.71152466
15MP0002452_abnormal_antigen_presenting1.70481088
16MP0003121_genomic_imprinting1.70131703
17MP0000685_abnormal_immune_system1.67912511
18MP0008877_abnormal_DNA_methylation1.64711271
19MP0010307_abnormal_tumor_latency1.62461741
20MP0002938_white_spotting1.61675810
21MP0002398_abnormal_bone_marrow1.59117342
22MP0005000_abnormal_immune_tolerance1.57623796
23MP0005076_abnormal_cell_differentiation1.55525256
24MP0005671_abnormal_response_to1.55458648
25MP0003763_abnormal_thymus_physiology1.53660167
26MP0002723_abnormal_immune_serum1.52326569
27MP0006054_spinal_hemorrhage1.51312472
28MP0003950_abnormal_plasma_membrane1.51198316
29MP0001790_abnormal_immune_system1.50522735
30MP0005387_immune_system_phenotype1.50522735
31MP0001819_abnormal_immune_cell1.48674877
32MP0002420_abnormal_adaptive_immunity1.48616352
33MP0009278_abnormal_bone_marrow1.47779765
34MP0002009_preneoplasia1.47626465
35MP0003077_abnormal_cell_cycle1.40889289
36MP0008058_abnormal_DNA_repair1.39984224
37MP0000703_abnormal_thymus_morphology1.39469743
38MP0002877_abnormal_melanocyte_morpholog1.39322403
39MP0002419_abnormal_innate_immunity1.38161375
40MP0009785_altered_susceptibility_to1.36903572
41MP0008438_abnormal_cutaneous_collagen1.35442947
42MP0003787_abnormal_imprinting1.34273295
43MP0008260_abnormal_autophagy1.31895381
44MP0001545_abnormal_hematopoietic_system1.31218360
45MP0005397_hematopoietic_system_phenotyp1.31218360
46MP0009697_abnormal_copulation1.29949443
47MP0002405_respiratory_system_inflammati1.29551028
48MP0002148_abnormal_hypersensitivity_rea1.28460217
49MP0002722_abnormal_immune_system1.27869001
50MP0000716_abnormal_immune_system1.27088202
51MP0003122_maternal_imprinting1.26848885
52MP0003436_decreased_susceptibility_to1.25150290
53MP0005621_abnormal_cell_physiology1.24483512
54MP0000689_abnormal_spleen_morphology1.23895904
55MP0010155_abnormal_intestine_physiology1.23237508
56MP0001293_anophthalmia1.21675903
57MP0001851_eye_inflammation1.21293450
58MP0000465_gastrointestinal_hemorrhage1.20692536
59MP0003111_abnormal_nucleus_morphology1.20288219
60MP0005025_abnormal_response_to1.19258812
61MP0000490_abnormal_crypts_of1.15883186
62MP0002933_joint_inflammation1.14388001
63MP0003868_abnormal_feces_composition1.14312062
64MP0003984_embryonic_growth_retardation1.13983291
65MP0003693_abnormal_embryo_hatching1.13950743
66MP0000015_abnormal_ear_pigmentation1.13927265
67MP0009333_abnormal_splenocyte_physiolog1.13679196
68MP0000428_abnormal_craniofacial_morphol1.12351209
69MP0002429_abnormal_blood_cell1.12239471
70MP0005464_abnormal_platelet_physiology1.11397930
71MP0003890_abnormal_embryonic-extraembry1.11284373
72MP0004957_abnormal_blastocyst_morpholog1.10003932
73MP0003724_increased_susceptibility_to1.09738582
74MP0002088_abnormal_embryonic_growth/wei1.09570064
75MP0003943_abnormal_hepatobiliary_system1.09432982
76MP0010368_abnormal_lymphatic_system1.08667293
77MP0005380_embryogenesis_phenotype1.07853513
78MP0001672_abnormal_embryogenesis/_devel1.07853513
79MP0003705_abnormal_hypodermis_morpholog1.07140072
80MP0005409_darkened_coat_color1.05257487
81MP0001915_intracranial_hemorrhage1.03948300
82MP0002928_abnormal_bile_duct1.02992190
83MP0001730_embryonic_growth_arrest1.02563509
84MP0002092_abnormal_eye_morphology1.01366727
85MP0004197_abnormal_fetal_growth/weight/1.01097010
86MP0003303_peritoneal_inflammation1.00789720
87MP0002086_abnormal_extraembryonic_tissu0.99050684
88MP0005310_abnormal_salivary_gland0.98041402
89MP0003828_pulmonary_edema0.97774844
90MP0000537_abnormal_urethra_morphology0.97153772
91MP0003448_altered_tumor_morphology0.96622116
92MP0001853_heart_inflammation0.96569091
93MP0004947_skin_inflammation0.96430831
94MP0002998_abnormal_bone_remodeling0.96104336
95MP0003566_abnormal_cell_adhesion0.94884115
96MP0000858_altered_metastatic_potential0.93287108
97MP0003183_abnormal_peptide_metabolism0.92391614
98MP0002925_abnormal_cardiovascular_devel0.92323551
99MP0003045_fibrosis0.91666928
100MP0000350_abnormal_cell_proliferation0.91095802
101MP0001873_stomach_inflammation0.90349484
102MP0002095_abnormal_skin_pigmentation0.90030549
103MP0000516_abnormal_urinary_system0.89998940
104MP0005367_renal/urinary_system_phenotyp0.89998940
105MP0003221_abnormal_cardiomyocyte_apopto0.89918016
106MP0005503_abnormal_tendon_morphology0.89681585
107MP0003656_abnormal_erythrocyte_physiolo0.89152418
108MP0003091_abnormal_cell_migration0.88812933
109MP0000733_abnormal_muscle_development0.87183044
110MP0009703_decreased_birth_body0.84457219
111MP0000313_abnormal_cell_death0.84010850
112MP0003935_abnormal_craniofacial_develop0.83182895
113MP0002177_abnormal_outer_ear0.82628032
114MP0003279_aneurysm0.82522305
115MP0001845_abnormal_inflammatory_respons0.82097315
116MP0001697_abnormal_embryo_size0.81495958
117MP0003937_abnormal_limbs/digits/tail_de0.81423963
118MP0010678_abnormal_skin_adnexa0.81219092
119MP0002697_abnormal_eye_size0.80997313
120MP0001188_hyperpigmentation0.80882304
121MP0010234_abnormal_vibrissa_follicle0.80765595
122MP0005384_cellular_phenotype0.80238808
123MP0002019_abnormal_tumor_incidence0.79947687
124MP0002138_abnormal_hepatobiliary_system0.79753614
125MP0001784_abnormal_fluid_regulation0.79588650
126MP0000767_abnormal_smooth_muscle0.79141336
127MP0004381_abnormal_hair_follicle0.75121526
128MP0004134_abnormal_chest_morphology0.74928759
129MP0002168_other_aberrant_phenotype0.73764933
130MP0002084_abnormal_developmental_patter0.73353698

Predicted human phenotypes

RankGene SetZ-score
1Syringomyelia (HP:0003396)3.31209712
2Spinal cord lesions (HP:0100561)3.31209712
3Abnormality of the fingertips (HP:0001211)3.22554173
4Heterotopia (HP:0002282)3.18683980
5Subacute progressive viral hepatitis (HP:0006572)2.93579700
6Volvulus (HP:0002580)2.88921074
7Optic neuritis (HP:0100653)2.79206963
8Retrobulbar optic neuritis (HP:0100654)2.79206963
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.76239794
10Short 4th metacarpal (HP:0010044)2.76239794
11Increased density of long bones (HP:0006392)2.72502941
12Colitis (HP:0002583)2.66660595
13Myositis (HP:0100614)2.64169401
14Papillary thyroid carcinoma (HP:0002895)2.59977394
15Acute myeloid leukemia (HP:0004808)2.56672037
16Spontaneous hematomas (HP:0007420)2.54435908
17Orchitis (HP:0100796)2.49951488
18Basal cell carcinoma (HP:0002671)2.42710144
19Chronic mucocutaneous candidiasis (HP:0002728)2.37614013
20Recurrent cutaneous fungal infections (HP:0011370)2.37614013
21Acute lymphatic leukemia (HP:0006721)2.32073888
22Absent frontal sinuses (HP:0002688)2.31732070
23Inflammation of the large intestine (HP:0002037)2.31070236
24Hematochezia (HP:0002573)2.30939906
25Conjunctival telangiectasia (HP:0000524)2.27338398
26Gastrointestinal inflammation (HP:0004386)2.26944023
27Persistence of primary teeth (HP:0006335)2.25219804
28Viral hepatitis (HP:0006562)2.22604217
29Sandal gap (HP:0001852)2.21785059
30Arterial thrombosis (HP:0004420)2.20365853
31Deep palmar crease (HP:0006191)2.19752585
32Recurrent viral infections (HP:0004429)2.15885665
33Deep philtrum (HP:0002002)2.14902928
34Periodontitis (HP:0000704)2.14896114
35Facial hemangioma (HP:0000329)2.12785860
36Chromsome breakage (HP:0040012)2.10334199
37Hypoplasia of the thymus (HP:0000778)2.08378014
38Abnormality of the nasal septum (HP:0000419)2.08132946
39Thyroiditis (HP:0100646)2.07838386
40IgM deficiency (HP:0002850)2.06959358
41Narrow palate (HP:0000189)2.02763284
42Thrombocytosis (HP:0001894)2.01369285
43Abnormal foot bone ossification (HP:0010675)2.00769539
44Long eyelashes (HP:0000527)2.00711493
45Asymmetry of the thorax (HP:0001555)2.00599738
46Lymphopenia (HP:0001888)1.99663345
47Severe combined immunodeficiency (HP:0004430)1.97718805
48Relative macrocephaly (HP:0004482)1.97519320
49Cystic hygroma (HP:0000476)1.97278387
50Autoimmune hemolytic anemia (HP:0001890)1.96595638
51B lymphocytopenia (HP:0010976)1.93693640
52Gastrointestinal stroma tumor (HP:0100723)1.91118093
53T lymphocytopenia (HP:0005403)1.90725265
54Skull defect (HP:0001362)1.89952944
55IgA deficiency (HP:0002720)1.89310614
56Abnormality of B cell number (HP:0010975)1.89270549
57Abnormality of the vasculature of the conjunctiva (HP:0008054)1.88957799
58Abnormality of cells of the lymphoid lineage (HP:0012140)1.88491685
59Cutis marmorata (HP:0000965)1.88166406
60Combined immunodeficiency (HP:0005387)1.87631026
61Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87027008
62Spondylolisthesis (HP:0003302)1.86691590
63Smooth philtrum (HP:0000319)1.86685028
64Ankyloglossia (HP:0010296)1.85612658
65Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84699732
66Granulocytopenia (HP:0001913)1.84622984
67Keratoconjunctivitis sicca (HP:0001097)1.84382858
68Ectopic kidney (HP:0000086)1.84343078
69Overgrowth (HP:0001548)1.83346246
70Elevated erythrocyte sedimentation rate (HP:0003565)1.81795780
7111 pairs of ribs (HP:0000878)1.81572634
72Abnormality of oral frenula (HP:0000190)1.81493048
73Abnormality of T cell number (HP:0011839)1.81269318
74Abnormality of DNA repair (HP:0003254)1.81228724
75Chronic hepatic failure (HP:0100626)1.80645851
76Transitional cell carcinoma of the bladder (HP:0006740)1.80130332
77Neoplasm of the oral cavity (HP:0100649)1.78993924
78Aortic aneurysm (HP:0004942)1.78236030
79Hypoplastic iliac wings (HP:0002866)1.78200754
80Eosinophilia (HP:0001880)1.78015825
81Midline defect of the nose (HP:0004122)1.77252303
82Cellulitis (HP:0100658)1.76859846
83Chronic diarrhea (HP:0002028)1.76509186
84Cafe-au-lait spot (HP:0000957)1.76399896
85Osteomyelitis (HP:0002754)1.75819301
86Thick eyebrow (HP:0000574)1.75256376
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75077149
88Amaurosis fugax (HP:0100576)1.74998400
89Prolonged bleeding time (HP:0003010)1.73925193
90Abnormal number of incisors (HP:0011064)1.73153494
91Prominent nose (HP:0000448)1.72793823
92Bicuspid aortic valve (HP:0001647)1.71531745
93Recurrent bronchitis (HP:0002837)1.71151276
94Broad palm (HP:0001169)1.70908422
95Capillary hemangiomas (HP:0005306)1.70824639
96Recurrent fungal infections (HP:0002841)1.70683948
97Renal duplication (HP:0000075)1.69780956
98Abnormal delayed hypersensitivity skin test (HP:0002963)1.68770103
99Low anterior hairline (HP:0000294)1.67923353
100Thickened helices (HP:0000391)1.67835668
101Myelodysplasia (HP:0002863)1.67471651
102Bladder carcinoma (HP:0002862)1.66790137
103Bladder neoplasm (HP:0009725)1.66790137
104Neoplasm of the tracheobronchial system (HP:0100552)1.66353003
105Abnormality of the 4th metacarpal (HP:0010012)1.66060018
106Vasculitis (HP:0002633)1.66050446
107Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64576189
108Mediastinal lymphadenopathy (HP:0100721)1.64072267
109Portal hypertension (HP:0001409)1.64047398
110High pitched voice (HP:0001620)1.63476534
111Nephroblastoma (Wilms tumor) (HP:0002667)1.63467981
112Verrucae (HP:0200043)1.62581821
113Papilloma (HP:0012740)1.62581821
114Eczematoid dermatitis (HP:0000976)1.62556014
115Obsessive-compulsive behavior (HP:0000722)1.62497929
116Abnormality of the peritoneum (HP:0002585)1.62451265
117Embryonal renal neoplasm (HP:0011794)1.61714702
118Reticulocytopenia (HP:0001896)1.61713369
119Medulloblastoma (HP:0002885)1.61618015
120Abnormal platelet volume (HP:0011876)1.60638093
121Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59990488
122Micronodular cirrhosis (HP:0001413)1.59917485
123Lymphoma (HP:0002665)1.59760247
124Panhypogammaglobulinemia (HP:0003139)1.58555220
125Cubitus valgus (HP:0002967)1.58547506
126Tapered finger (HP:0001182)1.58542207
127Abnormality of the radial head (HP:0003995)1.58215379
128Recurrent abscess formation (HP:0002722)1.58158609
129Abnormality of T cells (HP:0002843)1.57912134
130Keratoconjunctivitis (HP:0001096)1.57709377
131Increased nuchal translucency (HP:0010880)1.57386535
132Large earlobe (HP:0009748)1.57289736
133Meningitis (HP:0001287)1.56574155
134Optic nerve coloboma (HP:0000588)1.56533063
135Truncal obesity (HP:0001956)1.54942057
136Abnormality of the pleura (HP:0002103)1.54564588
137Short middle phalanx of the 5th finger (HP:0004220)1.54045490
138Mesomelia (HP:0003027)1.53997453
139Wide nose (HP:0000445)1.53804507
140Abnormality of the hepatic vasculature (HP:0006707)1.53720978
141IgG deficiency (HP:0004315)1.53272034
142Hyperacusis (HP:0010780)1.52090895
143Dislocated radial head (HP:0003083)1.51461619
144Shallow orbits (HP:0000586)1.50611125
145Abnormality of chromosome stability (HP:0003220)1.49789034
146Cerebral aneurysm (HP:0004944)1.49209290
147Hepatitis (HP:0012115)1.48327307
148Basal ganglia calcification (HP:0002135)1.48275926
149Agnosia (HP:0010524)1.47977869
150Malignant gastrointestinal tract tumors (HP:0006749)1.46837427
151Gastrointestinal carcinoma (HP:0002672)1.46837427
152Premature loss of primary teeth (HP:0006323)1.46752576
153Prostate neoplasm (HP:0100787)1.46491634
154Macroorchidism (HP:0000053)1.45827489
155Agammaglobulinemia (HP:0004432)1.45237517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B2.68612305
2MAP3K102.66129819
3CDK122.63706688
4BRD42.51509523
5JAK32.24249038
6MAP3K142.20787054
7TGFBR12.16041623
8AKT32.12283497
9NUAK12.06997611
10TXK2.03874975
11EEF2K1.98586956
12LATS11.73087292
13IRAK31.72555044
14MAP3K91.67902647
15EIF2AK31.66522999
16MKNK11.65821931
17MAP4K11.64756449
18CDC71.61663992
19TEC1.53499165
20KIT1.53077763
21STK101.51447313
22PKN21.50016098
23PTK61.49932564
24TGFBR21.46221150
25ITK1.44915512
26BTK1.44631273
27CHUK1.43124867
28FLT31.41567945
29RPS6KA41.41031686
30EPHA31.40640765
31ZAK1.40454891
32NEK21.38155417
33STK31.37965781
34FGFR31.35929713
35PASK1.32980623
36ATR1.30401882
37TAOK31.28840998
38RAF11.28157031
39KSR21.27461506
40IRAK41.26964460
41ERBB31.26833994
42CDK61.25724373
43IKBKB1.24866361
44RIPK41.21564228
45TRPM71.20909713
46JAK11.20641176
47FES1.20094808
48YES11.15647688
49WNK11.12804275
50PIM11.11366141
51CDK91.10504515
52RIPK11.09047975
53STK241.05166289
54TYK21.04121189
55ACVR1B1.02664137
56MKNK21.00132434
57RPS6KB20.99782498
58SRPK10.98864637
59BLK0.98279728
60MAP3K70.97070071
61IKBKE0.95125388
62TSSK60.95072582
63CSF1R0.94362974
64FRK0.93210641
65NEK90.91823238
66PDGFRB0.90898178
67PDGFRA0.90105564
68STK40.90058618
69PLK40.89057891
70BRAF0.87998654
71LCK0.87005313
72CAMK1D0.86198927
73KSR10.86140639
74TBK10.85210384
75HCK0.84611923
76EIF2AK20.84074576
77CSK0.81825823
78BMPR20.80578126
79TAF10.80518199
80MARK30.78622424
81HIPK20.78518621
82BMPR1B0.76393030
83CLK10.75335492
84MAPK110.74573352
85SGK20.73200438
86SIK10.72946351
87ATM0.72934306
88SYK0.72904442
89LYN0.72332063
90CAMK1G0.71176807
91TTK0.70960335
92CDK40.70220710
93MAPK70.70095309
94INSRR0.68080485
95SIK20.67851387
96CSNK1A1L0.67653624
97DYRK30.66764708
98BRSK20.66090583
99TTN0.64923980
100RPS6KA50.64502538
101LRRK20.64088099
102MAP2K30.63657316
103ZAP700.62780075
104MAP3K20.60197228
105CHEK10.59349846
106SGK30.59336535
107AURKB0.57834353
108RPS6KB10.57537625
109TIE10.57524046
110NLK0.56565830
111CAMKK20.55960555
112SGK2230.55935871
113SGK4940.55935871
114VRK10.55151114
115GRK60.54781981
116MELK0.52877873
117MTOR0.52317527
118CDK30.52170685
119PNCK0.51805630
120MOS0.50983513
121CDK70.50829306
122CDK80.50700993
123PRKCQ0.50676303
124PIK3CG0.49867488
125MAP3K130.49587447
126SCYL20.49562155
127CDC42BPA0.48662744
128RPS6KA60.47948713
129TRIB30.47726109
130RPS6KL10.47558405
131RPS6KC10.47558405
132PAK20.47502721
133TYRO30.47185004
134PLK30.46571895
135MAP3K80.46248032
136NEK60.46208811
137MAP3K60.44049503
138WEE10.42875113
139IRAK10.42076632

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.33478449
2Measles_Homo sapiens_hsa051621.87481469
3Leishmaniasis_Homo sapiens_hsa051401.84963633
4Osteoclast differentiation_Homo sapiens_hsa043801.80561479
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79812284
6DNA replication_Homo sapiens_hsa030301.71879833
7B cell receptor signaling pathway_Homo sapiens_hsa046621.70706905
8Primary immunodeficiency_Homo sapiens_hsa053401.66105193
9Herpes simplex infection_Homo sapiens_hsa051681.62226141
10Transcriptional misregulation in cancer_Homo sapiens_hsa052021.60319430
11Dorso-ventral axis formation_Homo sapiens_hsa043201.56813011
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55459832
13Systemic lupus erythematosus_Homo sapiens_hsa053221.55366142
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50243451
15Mismatch repair_Homo sapiens_hsa034301.49084916
16TNF signaling pathway_Homo sapiens_hsa046681.48563680
17Chronic myeloid leukemia_Homo sapiens_hsa052201.45972265
18Hematopoietic cell lineage_Homo sapiens_hsa046401.40121521
19Antigen processing and presentation_Homo sapiens_hsa046121.39705567
20Non-homologous end-joining_Homo sapiens_hsa034501.38785553
21MicroRNAs in cancer_Homo sapiens_hsa052061.37453605
22One carbon pool by folate_Homo sapiens_hsa006701.36368429
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35074236
24Small cell lung cancer_Homo sapiens_hsa052221.34743287
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32827383
26Base excision repair_Homo sapiens_hsa034101.32321608
27Allograft rejection_Homo sapiens_hsa053301.32077476
28Toxoplasmosis_Homo sapiens_hsa051451.31799103
29Renal cell carcinoma_Homo sapiens_hsa052111.30085274
30T cell receptor signaling pathway_Homo sapiens_hsa046601.29495832
31Hepatitis B_Homo sapiens_hsa051611.29347862
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26931996
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.26816057
34Cell cycle_Homo sapiens_hsa041101.26371378
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.24686083
36Spliceosome_Homo sapiens_hsa030401.22942297
37Influenza A_Homo sapiens_hsa051641.22615702
38Thyroid cancer_Homo sapiens_hsa052161.19929534
39HTLV-I infection_Homo sapiens_hsa051661.18747376
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17450158
41Colorectal cancer_Homo sapiens_hsa052101.17274351
42Viral carcinogenesis_Homo sapiens_hsa052031.17117552
43Fanconi anemia pathway_Homo sapiens_hsa034601.16278084
44Legionellosis_Homo sapiens_hsa051341.14243417
45mRNA surveillance pathway_Homo sapiens_hsa030151.11912201
46Pancreatic cancer_Homo sapiens_hsa052121.11109576
47Graft-versus-host disease_Homo sapiens_hsa053321.09014792
48Choline metabolism in cancer_Homo sapiens_hsa052311.08484285
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06483534
50ErbB signaling pathway_Homo sapiens_hsa040121.05601262
51Platelet activation_Homo sapiens_hsa046111.05119577
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04238394
53Apoptosis_Homo sapiens_hsa042101.03962138
54Prostate cancer_Homo sapiens_hsa052151.03352027
55Acute myeloid leukemia_Homo sapiens_hsa052211.02539128
56p53 signaling pathway_Homo sapiens_hsa041151.02160657
57Homologous recombination_Homo sapiens_hsa034401.00890682
58Malaria_Homo sapiens_hsa051441.00342829
59Leukocyte transendothelial migration_Homo sapiens_hsa046701.00302408
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99956983
61Viral myocarditis_Homo sapiens_hsa054160.99397411
62Tuberculosis_Homo sapiens_hsa051520.98111890
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97894931
64Lysine degradation_Homo sapiens_hsa003100.97360144
65Adherens junction_Homo sapiens_hsa045200.96340330
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91646193
67Proteoglycans in cancer_Homo sapiens_hsa052050.90647851
68VEGF signaling pathway_Homo sapiens_hsa043700.88858519
69Chemokine signaling pathway_Homo sapiens_hsa040620.87897932
70Nucleotide excision repair_Homo sapiens_hsa034200.87773472
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86994759
72Non-small cell lung cancer_Homo sapiens_hsa052230.86773284
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86393826
74Focal adhesion_Homo sapiens_hsa045100.85717293
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85249633
76Pertussis_Homo sapiens_hsa051330.84878808
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.83131313
78Epstein-Barr virus infection_Homo sapiens_hsa051690.83056671
79FoxO signaling pathway_Homo sapiens_hsa040680.80458725
80Type I diabetes mellitus_Homo sapiens_hsa049400.79250836
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78348198
82RNA degradation_Homo sapiens_hsa030180.77891622
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.76706014
84TGF-beta signaling pathway_Homo sapiens_hsa043500.76583186
85Autoimmune thyroid disease_Homo sapiens_hsa053200.75741359
86Pathways in cancer_Homo sapiens_hsa052000.74699409
87Prolactin signaling pathway_Homo sapiens_hsa049170.74350422
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74181323
89Hepatitis C_Homo sapiens_hsa051600.73839907
90Salmonella infection_Homo sapiens_hsa051320.73209596
91Shigellosis_Homo sapiens_hsa051310.72517105
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71565480
93ECM-receptor interaction_Homo sapiens_hsa045120.70988328
94MAPK signaling pathway_Homo sapiens_hsa040100.68680388
95Notch signaling pathway_Homo sapiens_hsa043300.68521359
96Long-term potentiation_Homo sapiens_hsa047200.66775140
97Endometrial cancer_Homo sapiens_hsa052130.66208767
98Melanoma_Homo sapiens_hsa052180.65957848
99GnRH signaling pathway_Homo sapiens_hsa049120.65799848
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64920724
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64838172
102Glioma_Homo sapiens_hsa052140.64461104
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64165676
104Bladder cancer_Homo sapiens_hsa052190.62763822
105Asthma_Homo sapiens_hsa053100.62393605
106Basal transcription factors_Homo sapiens_hsa030220.61035092
107RNA transport_Homo sapiens_hsa030130.60710198
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.59886769
109Basal cell carcinoma_Homo sapiens_hsa052170.59812933
110Amoebiasis_Homo sapiens_hsa051460.58982506
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57899039
112Estrogen signaling pathway_Homo sapiens_hsa049150.57233035
113Alcoholism_Homo sapiens_hsa050340.57063775
114mTOR signaling pathway_Homo sapiens_hsa041500.56389734
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55940783
116Wnt signaling pathway_Homo sapiens_hsa043100.55169781
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54605025
118Type II diabetes mellitus_Homo sapiens_hsa049300.53669666
119Inositol phosphate metabolism_Homo sapiens_hsa005620.52424378

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