ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	4.81319023
2	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	4.40154176
3	myofibril assembly (GO:0030239)	4.10959276
4	nephron tubule morphogenesis (GO:0072078)	3.97794219
5	nephron epithelium morphogenesis (GO:0072088)	3.97794219
6	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.96762338
7	regulation of relaxation of muscle (GO:1901077)	3.84944320
8	establishment of protein localization to Golgi (GO:0072600)	3.82916767
9	interkinetic nuclear migration (GO:0022027)	3.73156756
10	regulation of skeletal muscle contraction (GO:0014819)	3.71030615
11	plasma membrane repair (GO:0001778)	3.69625022
12	renal tubule morphogenesis (GO:0061333)	3.67936549
13	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.62229943
14	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.61564500
15	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.58582339
16	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.41642562
17	nucleus localization (GO:0051647)	3.41424710
18	response to muscle activity (GO:0014850)	3.35568465
19	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.32617124
20	L-fucose catabolic process (GO:0042355)	3.31307111
21	fucose catabolic process (GO:0019317)	3.31307111
22	L-fucose metabolic process (GO:0042354)	3.31307111
23	urinary tract smooth muscle contraction (GO:0014848)	3.22214635
24	regulation of establishment of cell polarity (GO:2000114)	3.15689640
25	protein targeting to Golgi (GO:0000042)	3.07960014
26	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.07200660
27	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.05417968
28	muscle fiber development (GO:0048747)	3.03902589
29	adult heart development (GO:0007512)	3.03282065
30	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.01453250
31	cerebellar Purkinje cell differentiation (GO:0021702)	2.99363718
32	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.99175414
33	positive regulation of catecholamine secretion (GO:0033605)	2.97280580
34	muscle filament sliding (GO:0030049)	2.90810068
35	actin-myosin filament sliding (GO:0033275)	2.90810068
36	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.90652543
37	sulfation (GO:0051923)	2.87226272
38	atrial cardiac muscle cell action potential (GO:0086014)	2.84217031
39	cytoplasmic mRNA processing body assembly (GO:0033962)	2.82349478
40	cardiac myofibril assembly (GO:0055003)	2.82059972
41	tryptophan catabolic process (GO:0006569)	2.81872446
42	indole-containing compound catabolic process (GO:0042436)	2.81872446
43	indolalkylamine catabolic process (GO:0046218)	2.81872446
44	cardiac muscle hypertrophy (GO:0003300)	2.78713218
45	sarcomere organization (GO:0045214)	2.77757665
46	positive regulation of potassium ion transport (GO:0043268)	2.73500176
47	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.73417256
48	cardiac muscle cell action potential (GO:0086001)	2.72964122
49	relaxation of smooth muscle (GO:0044557)	2.71138709
50	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.71102819
51	regulation of cardiac muscle cell differentiation (GO:2000725)	2.70955599
52	membrane depolarization during action potential (GO:0086010)	2.70758019
53	dermatan sulfate biosynthetic process (GO:0030208)	2.69205320
54	regulation of myoblast differentiation (GO:0045661)	2.68983774
55	positive regulation of cation channel activity (GO:2001259)	2.68114157
56	cellular response to zinc ion (GO:0071294)	2.67483546
57	striated muscle hypertrophy (GO:0014897)	2.66939208
58	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.66509444
59	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.65928916
60	response to inactivity (GO:0014854)	2.60723547
61	cyclic nucleotide catabolic process (GO:0009214)	2.60477531
62	actin-mediated cell contraction (GO:0070252)	2.59897542
63	ganglioside metabolic process (GO:0001573)	2.59741624
64	relaxation of muscle (GO:0090075)	2.59148565
65	adrenergic receptor signaling pathway (GO:0071875)	2.58060924
66	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.57527558
67	ventricular cardiac muscle cell action potential (GO:0086005)	2.54727325
68	regulation of female receptivity (GO:0045924)	2.54685512
69	neuromuscular synaptic transmission (GO:0007274)	2.54657625
70	cAMP catabolic process (GO:0006198)	2.54565004
71	inositol metabolic process (GO:0006020)	2.52312937
72	actomyosin structure organization (GO:0031032)	2.52016603
73	cellular response to cadmium ion (GO:0071276)	2.51086513
74	myotube cell development (GO:0014904)	2.50825939
75	regulation of membrane repolarization (GO:0060306)	2.50003353
76	negative regulation of multicellular organism growth (GO:0040015)	2.47107306
77	regulation of potassium ion transmembrane transporter activity (GO:1901016)	2.46578081
78	regulation of energy homeostasis (GO:2000505)	2.46386103
79	establishment of nucleus localization (GO:0040023)	2.45640645
80	ADP metabolic process (GO:0046031)	2.45561160
81	labyrinthine layer development (GO:0060711)	2.45001166
82	smooth muscle contraction (GO:0006939)	2.44326469
83	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.43221750
84	action potential (GO:0001508)	2.41919167
85	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.40445919
86	regulation of translation, ncRNA-mediated (GO:0045974)	2.40445919
87	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.40445919
88	NAD biosynthetic process (GO:0009435)	2.38607395
89	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.38548079
90	tryptophan metabolic process (GO:0006568)	2.38325148
91	glycosphingolipid biosynthetic process (GO:0006688)	2.37955654
92	dermatan sulfate metabolic process (GO:0030205)	2.37766831
93	positive regulation of myoblast differentiation (GO:0045663)	2.36393191
94	cardiac conduction (GO:0061337)	2.36085434
95	peripheral nervous system axon ensheathment (GO:0032292)	2.35809831
96	myelination in peripheral nervous system (GO:0022011)	2.35809831
97	regulation of gene silencing by RNA (GO:0060966)	2.35376859
98	regulation of posttranscriptional gene silencing (GO:0060147)	2.35376859
99	regulation of gene silencing by miRNA (GO:0060964)	2.35376859
100	positive regulation of muscle hypertrophy (GO:0014742)	2.34186712

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.11463986
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.76429808
3	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.80361328
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.77755280
5	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.58055720
6	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.36878645
7	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.26796683
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.25568647
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.24414360
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.15573729
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.15118762
12	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.09351226
13	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.99211444
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.97178846
15	AHR_22903824_ChIP-Seq_MCF-7_Human	1.96432253
16	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.93761060
17	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.89486810
18	EZH2_22144423_ChIP-Seq_EOC_Human	1.85412498
19	P300_19829295_ChIP-Seq_ESCs_Human	1.82535093
20	VDR_22108803_ChIP-Seq_LS180_Human	1.82333547
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.80921775
22	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.78178024
23	STAT3_23295773_ChIP-Seq_U87_Human	1.77926688
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.75373331
25	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.74760384
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.74554578
27	ZNF274_21170338_ChIP-Seq_K562_Hela	1.73534959
28	TP53_16413492_ChIP-PET_HCT116_Human	1.72953341
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.70710674
30	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.70658121
31	AR_21572438_ChIP-Seq_LNCaP_Human	1.69128309
32	FUS_26573619_Chip-Seq_HEK293_Human	1.68933774
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68512086
34	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.63444349
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.62616935
36	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.59424962
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57553109
38	TCF4_23295773_ChIP-Seq_U87_Human	1.57268645
39	EWS_26573619_Chip-Seq_HEK293_Human	1.55567747
40	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.54560262
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.49104551
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48719511
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.48719511
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.47576842
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46817451
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.46817451
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46544053
48	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.46035110
49	DROSHA_22980978_ChIP-Seq_HELA_Human	1.43074253
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42690922
51	RXR_22108803_ChIP-Seq_LS180_Human	1.41048850
52	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.39815206
53	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.38517928
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37345760
55	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.37296998
56	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.37296998
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35051383
58	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.34930516
59	AR_25329375_ChIP-Seq_VCAP_Human	1.34872177
60	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.32589112
61	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.31486974
62	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30063268
63	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.27830624
64	GATA1_22025678_ChIP-Seq_K562_Human	1.25975280
65	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.21239379
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21075016
67	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.18286607
68	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.18240375
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18035993
70	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.16439373
71	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.15975817
72	TP53_18474530_ChIP-ChIP_U2OS_Human	1.13305454
73	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.12411194
74	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11320970
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10574829
76	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.09534897
77	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.09365313
78	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08942872
79	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.08825843
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06661870
81	CJUN_26792858_Chip-Seq_BT549_Human	1.06458332
82	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.05646870
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.05468776
84	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.05355879
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04301010
86	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.03630419
87	CDX2_22108803_ChIP-Seq_LS180_Human	1.03463152
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03245618
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02128698
90	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01726233
91	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.01724116
92	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.01217377
93	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.01200605
94	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.00657888
95	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00443947
96	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00443947
97	KDM2B_26808549_Chip-Seq_REH_Human	1.00161004
98	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00149252
99	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.99786188
100	AR_19668381_ChIP-Seq_PC3_Human	0.98772031

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010386_abnormal_urinary_bladder	3.35319778
2	MP0000749_muscle_degeneration	3.34916412
3	MP0004145_abnormal_muscle_electrophysio	3.24578948
4	MP0004084_abnormal_cardiac_muscle	3.22932388
5	MP0002837_dystrophic_cardiac_calcinosis	2.79564537
6	MP0004036_abnormal_muscle_relaxation	2.69843809
7	MP0004215_abnormal_myocardial_fiber	2.39575461
8	MP0003646_muscle_fatigue	2.29689449
9	MP0005646_abnormal_pituitary_gland	2.28774228
10	MP0009697_abnormal_copulation	2.21346083
11	MP0004043_abnormal_pH_regulation	2.16832304
12	MP0005620_abnormal_muscle_contractility	2.09019705
13	MP0000013_abnormal_adipose_tissue	2.06519163
14	MP0009046_muscle_twitch	2.05449250
15	MP0010368_abnormal_lymphatic_system	2.05421227
16	MP0004484_altered_response_of	1.95811210
17	MP0002108_abnormal_muscle_morphology	1.90339212
18	MP0001501_abnormal_sleep_pattern	1.81192176
19	MP0002876_abnormal_thyroid_physiology	1.80289114
20	MP0000383_abnormal_hair_follicle	1.72628507
21	MP0001485_abnormal_pinna_reflex	1.72608243
22	MP0002127_abnormal_cardiovascular_syste	1.68459429
23	MP0004134_abnormal_chest_morphology	1.66803024
24	MP0003045_fibrosis	1.65987575
25	MP0009780_abnormal_chondrocyte_physiolo	1.64376074
26	MP0008775_abnormal_heart_ventricle	1.59568769
27	MP0003890_abnormal_embryonic-extraembry	1.58598729
28	MP0002638_abnormal_pupillary_reflex	1.57748443
29	MP0006138_congestive_heart_failure	1.57510051
30	MP0003868_abnormal_feces_composition	1.54340613
31	MP0005330_cardiomyopathy	1.52029130
32	MP0000751_myopathy	1.49673221
33	MP0000538_abnormal_urinary_bladder	1.42252801
34	MP0002160_abnormal_reproductive_system	1.42005187
35	MP0004087_abnormal_muscle_fiber	1.41658470
36	MP0005645_abnormal_hypothalamus_physiol	1.39983781
37	MP0001486_abnormal_startle_reflex	1.38651695
38	MP0001661_extended_life_span	1.36001222
39	MP0004130_abnormal_muscle_cell	1.35507486
40	MP0000613_abnormal_salivary_gland	1.34584580
41	MP0003828_pulmonary_edema	1.32534530
42	MP0005187_abnormal_penis_morphology	1.29716371
43	MP0008057_abnormal_DNA_replication	1.27668815
44	MP0002269_muscular_atrophy	1.26727924
45	MP0000747_muscle_weakness	1.25596352
46	MP0002138_abnormal_hepatobiliary_system	1.25340930
47	MP0002272_abnormal_nervous_system	1.24751537
48	MP0002102_abnormal_ear_morphology	1.23581932
49	MP0005369_muscle_phenotype	1.21742215
50	MP0008004_abnormal_stomach_pH	1.20303813
51	MP0005275_abnormal_skin_tensile	1.19771393
52	MP0009250_abnormal_appendicular_skeleto	1.19222694
53	MP0000759_abnormal_skeletal_muscle	1.17941629
54	MP0004085_abnormal_heartbeat	1.17458745
55	MP0008961_abnormal_basal_metabolism	1.16930763
56	MP0001984_abnormal_olfaction	1.16554795
57	MP0004270_analgesia	1.14166292
58	MP0000462_abnormal_digestive_system	1.12776328
59	MP0003880_abnormal_central_pattern	1.12034107
60	MP0002972_abnormal_cardiac_muscle	1.11730165
61	MP0000230_abnormal_systemic_arterial	1.09735843
62	MP0000631_abnormal_neuroendocrine_gland	1.07979365
63	MP0003195_calcinosis	1.06925782
64	MP0002106_abnormal_muscle_physiology	1.06661280
65	MP0005595_abnormal_vascular_smooth	1.06533697
66	MP0003635_abnormal_synaptic_transmissio	1.05667555
67	MP0010678_abnormal_skin_adnexa	1.04635064
68	MP0001502_abnormal_circadian_rhythm	1.04414295
69	MP0001664_abnormal_digestion	1.03651882
70	MP0002064_seizures	1.03147227
71	MP0006072_abnormal_retinal_apoptosis	1.02757834
72	MP0003633_abnormal_nervous_system	1.00119302
73	MP0000733_abnormal_muscle_development	0.99927610
74	MP0003879_abnormal_hair_cell	0.99883894
75	MP0005167_abnormal_blood-brain_barrier	0.99600358
76	MP0008875_abnormal_xenobiotic_pharmacok	0.99121756
77	MP0001879_abnormal_lymphatic_vessel	0.98366652
78	MP0004272_abnormal_basement_membrane	0.97090044
79	MP0004510_myositis	0.93889506
80	MP0002249_abnormal_larynx_morphology	0.92508009
81	MP0006276_abnormal_autonomic_nervous	0.91676864
82	MP0001299_abnormal_eye_distance/	0.90777456
83	MP0003632_abnormal_nervous_system	0.90566304
84	MP0001544_abnormal_cardiovascular_syste	0.89737172
85	MP0005385_cardiovascular_system_phenoty	0.89737172
86	MP0002332_abnormal_exercise_endurance	0.89630375
87	MP0002168_other_aberrant_phenotype	0.89057614
88	MP0009745_abnormal_behavioral_response	0.88285513
89	MP0002063_abnormal_learning/memory/cond	0.87242409
90	MP0005647_abnormal_sex_gland	0.86448673
91	MP0000428_abnormal_craniofacial_morphol	0.84113046
92	MP0005386_behavior/neurological_phenoty	0.83645328
93	MP0004924_abnormal_behavior	0.83645328
94	MP0003631_nervous_system_phenotype	0.82934641
95	MP0003950_abnormal_plasma_membrane	0.82623371
96	MP0005266_abnormal_metabolism	0.82444859
97	MP0000003_abnormal_adipose_tissue	0.82036268
98	MP0009115_abnormal_fat_cell	0.82018248
99	MP0010630_abnormal_cardiac_muscle	0.81902629
100	MP0003937_abnormal_limbs/digits/tail_de	0.81295309

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Clumsiness (HP:0002312)	5.16519882
2	Distal arthrogryposis (HP:0005684)	4.15962156
3	Hyperkalemia (HP:0002153)	4.08200234
4	Right ventricular cardiomyopathy (HP:0011663)	3.96608348
5	Broad-based gait (HP:0002136)	3.89888726
6	Genetic anticipation (HP:0003743)	3.67562572
7	Hyperventilation (HP:0002883)	3.64189038
8	Progressive cerebellar ataxia (HP:0002073)	3.59737643
9	Calf muscle hypertrophy (HP:0008981)	3.56404025
10	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.38504974
11	Abnormality of the calf musculature (HP:0001430)	3.37914397
12	Hyporeflexia of lower limbs (HP:0002600)	3.34903320
13	Muscle fiber inclusion bodies (HP:0100299)	3.25563115
14	Muscle hypertrophy of the lower extremities (HP:0008968)	3.25063150
15	Febrile seizures (HP:0002373)	3.20706270
16	Gaze-evoked nystagmus (HP:0000640)	3.20580919
17	Aortic aneurysm (HP:0004942)	3.19388257
18	Short chin (HP:0000331)	3.13000213
19	Inability to walk (HP:0002540)	2.97911872
20	Atonic seizures (HP:0010819)	2.92425063
21	Bulbous nose (HP:0000414)	2.81874493
22	EMG: myopathic abnormalities (HP:0003458)	2.75041188
23	Widely spaced teeth (HP:0000687)	2.70258435
24	Rimmed vacuoles (HP:0003805)	2.64060151
25	Midline defect of the nose (HP:0004122)	2.63570752
26	Nemaline bodies (HP:0003798)	2.63328379
27	Exercise-induced myalgia (HP:0003738)	2.59046756
28	Sensory axonal neuropathy (HP:0003390)	2.56752671
29	Scapular winging (HP:0003691)	2.54650404
30	Abnormality of the nasal septum (HP:0000419)	2.49928131
31	Poor eye contact (HP:0000817)	2.48750550
32	Progressive inability to walk (HP:0002505)	2.45619567
33	Urethral obstruction (HP:0000796)	2.45582558
34	Abnormality of the columella (HP:0009929)	2.44915554
35	Abnormality of chloride homeostasis (HP:0011422)	2.41533336
36	Postural instability (HP:0002172)	2.41459213
37	Areflexia of lower limbs (HP:0002522)	2.40144859
38	Difficulty running (HP:0009046)	2.39722028
39	Abnormality of the ischium (HP:0003174)	2.34630446
40	Hypothermia (HP:0002045)	2.34006370
41	Sudden death (HP:0001699)	2.29914443
42	Macroorchidism (HP:0000053)	2.28755875
43	Facial diplegia (HP:0001349)	2.27165657
44	Protruding tongue (HP:0010808)	2.24810326
45	Fair hair (HP:0002286)	2.20679328
46	Prolonged QT interval (HP:0001657)	2.18260780
47	Exercise-induced muscle cramps (HP:0003710)	2.16132467
48	Syncope (HP:0001279)	2.15154327
49	Abnormality of the shoulder girdle musculature (HP:0001435)	2.14568763
50	Drooling (HP:0002307)	2.14437455
51	Muscular dystrophy (HP:0003560)	2.13968975
52	Thyroid-stimulating hormone excess (HP:0002925)	2.12800214
53	Frequent falls (HP:0002359)	2.11642723
54	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.11394637
55	Type 1 muscle fiber predominance (HP:0003803)	2.10742191
56	Spontaneous abortion (HP:0005268)	2.09611613
57	Absent speech (HP:0001344)	2.08576086
58	Abnormality of potassium homeostasis (HP:0011042)	2.05312044
59	Ventricular fibrillation (HP:0001663)	2.03525026
60	Pancreatic cysts (HP:0001737)	2.03458303
61	Long clavicles (HP:0000890)	2.01677212
62	Chronic hepatic failure (HP:0100626)	1.96075714
63	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.94290259
64	Bundle branch block (HP:0011710)	1.92463151
65	Generalized hypopigmentation of hair (HP:0011358)	1.91670881
66	Pancreatic fibrosis (HP:0100732)	1.91105447
67	Hypoplastic ischia (HP:0003175)	1.89411110
68	Excessive salivation (HP:0003781)	1.89384961
69	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.85400037
70	Short 4th metacarpal (HP:0010044)	1.85400037
71	Hepatoblastoma (HP:0002884)	1.85317476
72	Tubulointerstitial nephritis (HP:0001970)	1.85027899
73	Focal seizures (HP:0007359)	1.84048921
74	Truncal ataxia (HP:0002078)	1.80754909
75	Cerebellar dysplasia (HP:0007033)	1.80704118
76	Impaired social interactions (HP:0000735)	1.80258686
77	Abnormal social behavior (HP:0012433)	1.80258686
78	Lower limb muscle weakness (HP:0007340)	1.80152556
79	Ankle clonus (HP:0011448)	1.79647797
80	Blue irides (HP:0000635)	1.78230646
81	Ulnar deviation of the wrist (HP:0003049)	1.76765720
82	Proximal amyotrophy (HP:0007126)	1.75156538
83	Dialeptic seizures (HP:0011146)	1.71903769
84	True hermaphroditism (HP:0010459)	1.71359747
85	Overgrowth (HP:0001548)	1.71336062
86	Narrow palate (HP:0000189)	1.69311903
87	Neck muscle weakness (HP:0000467)	1.69114964
88	Impaired vibratory sensation (HP:0002495)	1.68147940
89	Decreased central vision (HP:0007663)	1.66321748
90	Pachygyria (HP:0001302)	1.65010488
91	Attenuation of retinal blood vessels (HP:0007843)	1.63169382
92	Urinary urgency (HP:0000012)	1.63141497
93	Downturned corners of mouth (HP:0002714)	1.62458893
94	Macular degeneration (HP:0000608)	1.60871199
95	Astrocytoma (HP:0009592)	1.60844520
96	Abnormality of the astrocytes (HP:0100707)	1.60844520
97	Steppage gait (HP:0003376)	1.60421910
98	High anterior hairline (HP:0009890)	1.59527564
99	Muscle fiber splitting (HP:0003555)	1.59517921
100	Primary atrial arrhythmia (HP:0001692)	1.59333819

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	5.32065135
2	PINK1	5.28646972
3	FRK	4.10760530
4	INSRR	3.07584155
5	LATS1	2.70603884
6	CASK	2.56092654
7	AKT3	1.97449371
8	MAP3K4	1.89620828
9	PHKG2	1.76313809
10	PHKG1	1.76313809
11	MAP2K7	1.72922401
12	MAP3K9	1.52433911
13	DAPK2	1.51265316
14	TNIK	1.48011296
15	SGK2	1.46694239
16	GRK1	1.45334671
17	MYLK	1.41850233
18	BMPR1B	1.40524744
19	ADRBK2	1.39259392
20	WNK1	1.38562606
21	CDC42BPA	1.38451058
22	MARK3	1.37645185
23	CDK12	1.36061973
24	PIK3CA	1.29125689
25	KIT	1.28456934
26	TIE1	1.28231115
27	TLK1	1.26148911
28	CSNK1A1L	1.26028950
29	ZAK	1.20621025
30	STK38L	1.18968198
31	ACVR1B	1.18043358
32	STK38	1.17630242
33	SGK223	1.14601590
34	SGK494	1.14601590
35	FGFR2	1.07272948
36	DMPK	1.04170387
37	PBK	1.04065438
38	CAMK1G	1.02393082
39	WNK4	1.01847278
40	CAMK1D	1.00975742
41	NLK	1.00203512
42	TEC	0.97154710
43	MAP4K2	0.96872170
44	FLT3	0.93999679
45	STK39	0.90160150
46	CDK3	0.88932801
47	SGK3	0.86824639
48	NEK2	0.85779040
49	MAP3K7	0.84106001
50	FER	0.82848835
51	EPHA4	0.81453590
52	WNK3	0.79212851
53	PTK2B	0.78656020
54	CSNK1G1	0.78392136
55	PAK3	0.74909437
56	CSF1R	0.69036317
57	CSNK1G3	0.67788412
58	TRPM7	0.67629905
59	TAOK3	0.67326583
60	CAMK4	0.66763439
61	BTK	0.65190424
62	CCNB1	0.65081726
63	MAPK13	0.64564556
64	CLK1	0.61138314
65	ROCK1	0.59382378
66	MELK	0.58094399
67	MARK1	0.57302267
68	CSNK1G2	0.56652852
69	LATS2	0.56106715
70	FGFR3	0.55783495
71	PRKAA2	0.55686297
72	ADRBK1	0.54435492
73	SGK1	0.52510378
74	PKN2	0.51517824
75	MET	0.50978180
76	CAMK1	0.50967701
77	PRKAA1	0.49826256
78	PRKG1	0.47692758
79	OXSR1	0.46221458
80	NTRK3	0.46162341
81	MAP2K4	0.44899399
82	MTOR	0.42967171
83	MUSK	0.42668995
84	BCR	0.41601559
85	EGFR	0.41583853
86	CAMK2D	0.41235443
87	RET	0.39572676
88	HCK	0.39471101
89	RPS6KB1	0.38007604
90	TGFBR2	0.37935124
91	PDGFRA	0.37852367
92	RIPK1	0.36654707
93	ABL1	0.36536671
94	PRKCE	0.36387851
95	PDGFRB	0.35747331
96	PRKACB	0.35286527
97	STK3	0.34829756
98	CDK5	0.32711881
99	MAPK11	0.32300386
100	MAPK7	0.31906156

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vascular smooth muscle contraction_Homo sapiens_hsa04270	2.29015496
2	Taste transduction_Homo sapiens_hsa04742	2.21300349
3	Renin secretion_Homo sapiens_hsa04924	2.05448039
4	Circadian entrainment_Homo sapiens_hsa04713	1.96204661
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.95435491
6	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.94337800
7	Insulin secretion_Homo sapiens_hsa04911	1.91849448
8	Salivary secretion_Homo sapiens_hsa04970	1.84529961
9	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.83213656
10	Calcium signaling pathway_Homo sapiens_hsa04020	1.81312049
11	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.78252495
12	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.75229956
13	Circadian rhythm_Homo sapiens_hsa04710	1.67531738
14	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.66473670
15	Asthma_Homo sapiens_hsa05310	1.64952543
16	Nicotine addiction_Homo sapiens_hsa05033	1.52575234
17	Gastric acid secretion_Homo sapiens_hsa04971	1.52485028
18	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.46955748
19	Type II diabetes mellitus_Homo sapiens_hsa04930	1.46827192
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.42294840
21	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.40997119
22	Olfactory transduction_Homo sapiens_hsa04740	1.40472568
23	Glutamatergic synapse_Homo sapiens_hsa04724	1.37924813
24	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.37450836
25	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.30184849
26	Morphine addiction_Homo sapiens_hsa05032	1.30042043
27	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.27206620
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.26618198
29	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.25056532
30	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.24730180
31	GABAergic synapse_Homo sapiens_hsa04727	1.22368574
32	ABC transporters_Homo sapiens_hsa02010	1.19359367
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.16899896
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.13738000
35	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.12744452
36	Cholinergic synapse_Homo sapiens_hsa04725	1.10522666
37	Dopaminergic synapse_Homo sapiens_hsa04728	1.09392603
38	Long-term depression_Homo sapiens_hsa04730	1.05081663
39	Platelet activation_Homo sapiens_hsa04611	1.04721443
40	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.02407719
41	cAMP signaling pathway_Homo sapiens_hsa04024	1.00834315
42	Other glycan degradation_Homo sapiens_hsa00511	0.99748242
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98858397
44	Butanoate metabolism_Homo sapiens_hsa00650	0.97333844
45	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.94918241
46	Tight junction_Homo sapiens_hsa04530	0.93631997
47	Mineral absorption_Homo sapiens_hsa04978	0.93563937
48	Amphetamine addiction_Homo sapiens_hsa05031	0.91962996
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.91404952
50	Lysine degradation_Homo sapiens_hsa00310	0.90791613
51	Graft-versus-host disease_Homo sapiens_hsa05332	0.90710229
52	Propanoate metabolism_Homo sapiens_hsa00640	0.90403866
53	Pancreatic secretion_Homo sapiens_hsa04972	0.90177160
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.90049236
55	Long-term potentiation_Homo sapiens_hsa04720	0.89051653
56	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.89008516
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.87397096
58	ECM-receptor interaction_Homo sapiens_hsa04512	0.85845118
59	Melanoma_Homo sapiens_hsa05218	0.84036200
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.83316019
61	Regulation of autophagy_Homo sapiens_hsa04140	0.82573908
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.80207195
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.79480854
64	Gap junction_Homo sapiens_hsa04540	0.76313302
65	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.74820374
66	Tryptophan metabolism_Homo sapiens_hsa00380	0.74161726
67	Wnt signaling pathway_Homo sapiens_hsa04310	0.71808121
68	Allograft rejection_Homo sapiens_hsa05330	0.71553067
69	Serotonergic synapse_Homo sapiens_hsa04726	0.68802514
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.68513455
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.68067800
72	Insulin resistance_Homo sapiens_hsa04931	0.65245552
73	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62501258
74	Glucagon signaling pathway_Homo sapiens_hsa04922	0.59958518
75	Cocaine addiction_Homo sapiens_hsa05030	0.59847677
76	Adherens junction_Homo sapiens_hsa04520	0.58501052
77	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.58339804
78	Glioma_Homo sapiens_hsa05214	0.58171679
79	Hippo signaling pathway_Homo sapiens_hsa04390	0.57118128
80	Phototransduction_Homo sapiens_hsa04744	0.56870889
81	Melanogenesis_Homo sapiens_hsa04916	0.56707551
82	FoxO signaling pathway_Homo sapiens_hsa04068	0.56191611
83	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.56181471
84	ErbB signaling pathway_Homo sapiens_hsa04012	0.56070507
85	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.55398305
86	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.55382513
87	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.54302437
88	Focal adhesion_Homo sapiens_hsa04510	0.52046943
89	Linoleic acid metabolism_Homo sapiens_hsa00591	0.51826136
90	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.51436112
91	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.47818092
92	Sulfur metabolism_Homo sapiens_hsa00920	0.47182344
93	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.46894909
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46590600
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46447672
96	Alcoholism_Homo sapiens_hsa05034	0.45466315
97	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.45131472
98	MAPK signaling pathway_Homo sapiens_hsa04010	0.45015634
99	Choline metabolism in cancer_Homo sapiens_hsa05231	0.44476029
100	Prostate cancer_Homo sapiens_hsa05215	0.42249546

UHRF2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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