ULBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88149563
2positive regulation by symbiont of host defense response (GO:0052509)4.31738822
3modulation by symbiont of host defense response (GO:0052031)4.31738822
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.31738822
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.31738822
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.31738822
7modulation by symbiont of host immune response (GO:0052553)4.31738822
8DNA double-strand break processing (GO:0000729)4.29793983
9neutrophil activation involved in immune response (GO:0002283)4.25079010
10positive regulation of gamma-delta T cell activation (GO:0046645)3.92912399
11protein K11-linked deubiquitination (GO:0035871)3.91714508
12proteasome assembly (GO:0043248)3.91203193
13replication fork processing (GO:0031297)3.84332691
14positive regulation of interferon-alpha production (GO:0032727)3.73703792
15regulation of interferon-alpha production (GO:0032647)3.55336997
16regulation of interferon-beta biosynthetic process (GO:0045357)3.54740618
17antigen processing and presentation of endogenous antigen (GO:0019883)3.48315083
18cullin deneddylation (GO:0010388)3.45906801
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.44513943
20response to peptidoglycan (GO:0032494)3.42761256
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.40500801
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.40500801
23immunoglobulin mediated immune response (GO:0016064)3.38154732
24B cell mediated immunity (GO:0019724)3.34310256
25protein K6-linked ubiquitination (GO:0085020)3.33841741
26regulation of B cell receptor signaling pathway (GO:0050855)3.31336580
27protein prenylation (GO:0018342)3.29964293
28prenylation (GO:0097354)3.29964293
29positive regulation of B cell differentiation (GO:0045579)3.20478302
30protein deneddylation (GO:0000338)3.17312118
31response to pheromone (GO:0019236)3.12541186
32Arp2/3 complex-mediated actin nucleation (GO:0034314)3.11353190
33response to X-ray (GO:0010165)3.10221656
34cellular response to exogenous dsRNA (GO:0071360)3.09789431
35macrophage activation involved in immune response (GO:0002281)3.09216469
36neutrophil activation (GO:0042119)3.03887848
37protein localization to kinetochore (GO:0034501)3.03376505
38cellular response to interferon-beta (GO:0035458)3.01480623
39response to muramyl dipeptide (GO:0032495)3.01381074
40maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99226167
41response to type I interferon (GO:0034340)2.97977803
42regulation of DNA endoreduplication (GO:0032875)2.97833597
43protein heterotetramerization (GO:0051290)2.97465513
44negative regulation of DNA-dependent DNA replication (GO:2000104)2.97223303
45granulocyte activation (GO:0036230)2.96585044
46NIK/NF-kappaB signaling (GO:0038061)2.96183495
47cellular response to type I interferon (GO:0071357)2.96119648
48type I interferon signaling pathway (GO:0060337)2.96119648
49myeloid cell activation involved in immune response (GO:0002275)2.92631932
50DNA unwinding involved in DNA replication (GO:0006268)2.90967540
51nuclear pore complex assembly (GO:0051292)2.90022035
52telomere maintenance via recombination (GO:0000722)2.89902993
53DNA strand elongation involved in DNA replication (GO:0006271)2.89256988
54regulation of B cell differentiation (GO:0045577)2.89222272
55response to host immune response (GO:0052572)2.88213956
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.88213956
57telomere maintenance via semi-conservative replication (GO:0032201)2.85956452
58response to interferon-alpha (GO:0035455)2.85413748
59production of molecular mediator involved in inflammatory response (GO:0002532)2.85170556
60defense response to protozoan (GO:0042832)2.84992159
61mitotic recombination (GO:0006312)2.84289174
62positive regulation of interferon-beta production (GO:0032728)2.84093670
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.83670821
64negative thymic T cell selection (GO:0045060)2.83043079
65behavioral response to ethanol (GO:0048149)2.83033574
66regulation of interleukin-12 biosynthetic process (GO:0045075)2.82011570
67leukocyte aggregation (GO:0070486)2.81596715
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81452999
69cellular response to zinc ion (GO:0071294)2.80717350
70negative regulation of phagocytosis (GO:0050765)2.80059398
71negative regulation of axon guidance (GO:1902668)2.79671707
72recombinational repair (GO:0000725)2.77712848
73double-strand break repair via homologous recombination (GO:0000724)2.76984944
74positive regulation of natural killer cell differentiation (GO:0032825)2.75702925
75positive regulation of antigen processing and presentation (GO:0002579)2.75561776
76DNA strand elongation (GO:0022616)2.75351997
77negative T cell selection (GO:0043383)2.75142083
78myeloid dendritic cell activation (GO:0001773)2.75069555
79positive regulation of defense response to virus by host (GO:0002230)2.74215583
80mast cell activation (GO:0045576)2.73782235
81lactate metabolic process (GO:0006089)2.73691484
82T cell migration (GO:0072678)2.73470419
83respiratory burst (GO:0045730)2.71841823
84signal peptide processing (GO:0006465)2.70745562
85T cell apoptotic process (GO:0070231)2.69140219
86* natural killer cell mediated immunity (GO:0002228)2.68205397
87* natural killer cell mediated cytotoxicity (GO:0042267)2.68205397
88acrosome assembly (GO:0001675)2.67254191
89positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.66000953
90positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.64849366
91platelet dense granule organization (GO:0060155)2.64520943
92positive regulation of alpha-beta T cell proliferation (GO:0046641)2.64453793
93pore complex assembly (GO:0046931)2.64210059
94regulation of T-helper 1 cell differentiation (GO:0045625)2.63800177
95positive regulation of protein autophosphorylation (GO:0031954)2.63754456
96pinocytosis (GO:0006907)2.63547767
97response to host (GO:0075136)2.63418573
98response to host defenses (GO:0052200)2.63418573
99response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.63418573
100intraciliary transport (GO:0042073)2.63396446
101response to protozoan (GO:0001562)2.60629953
102B cell receptor signaling pathway (GO:0050853)2.60446977
103negative regulation of axon extension involved in axon guidance (GO:0048843)2.59453833
104regulation of alpha-beta T cell proliferation (GO:0046640)2.59435942
105double-strand break repair via nonhomologous end joining (GO:0006303)2.59297057
106non-recombinational repair (GO:0000726)2.59297057
107DNA catabolic process, exonucleolytic (GO:0000738)2.59226118
108protein localization to chromosome, centromeric region (GO:0071459)2.58522499
109positive regulation of interleukin-12 production (GO:0032735)2.58169311
110mitotic chromosome condensation (GO:0007076)2.58129680
111negative regulation of interleukin-17 production (GO:0032700)2.57966397
112negative regulation of viral genome replication (GO:0045071)2.57944083
113response to interferon-beta (GO:0035456)2.56914902
114mitotic sister chromatid cohesion (GO:0007064)2.55762453
115regulation of gamma-delta T cell activation (GO:0046643)2.54475000
116cilium morphogenesis (GO:0060271)2.54206329
117nuclear pore organization (GO:0006999)2.53262828
118histone-serine phosphorylation (GO:0035404)2.52877190
119actin nucleation (GO:0045010)2.52475092
120kinetochore organization (GO:0051383)2.51607572
121regulation of centriole replication (GO:0046599)2.51503315
122cellular response to interferon-alpha (GO:0035457)2.50843533
123regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.50385415
124regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.50312112
125dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.50141337
126interferon-gamma-mediated signaling pathway (GO:0060333)2.49322808
127regulation of antigen processing and presentation (GO:0002577)2.48903978
128regulation of dendritic cell antigen processing and presentation (GO:0002604)2.47845809
129negative regulation of B cell proliferation (GO:0030889)2.47699783
130metaphase plate congression (GO:0051310)2.46570722
131kinetochore assembly (GO:0051382)2.46495691
132signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.46387336
133signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.46387336
134signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.46387336
135positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44965727
136regulation of RIG-I signaling pathway (GO:0039535)2.44608549
137DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.44441122
138meiotic chromosome segregation (GO:0045132)2.44260806
139cellular extravasation (GO:0045123)2.43637187
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.43303248
141positive regulation of isotype switching (GO:0045830)2.43112979
142interferon-gamma production (GO:0032609)2.42881103
143respiratory chain complex IV assembly (GO:0008535)2.42715088
144intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.41781018
145signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.41781018
146anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.41264404
147signal transduction involved in cell cycle checkpoint (GO:0072395)2.40372488
148retinal ganglion cell axon guidance (GO:0031290)2.39036030
149negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.38473483
150attachment of spindle microtubules to kinetochore (GO:0008608)2.37746549
151synapsis (GO:0007129)2.37735193
152UDP-N-acetylglucosamine metabolic process (GO:0006047)2.35433764
153negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.34596587
154anterograde synaptic vesicle transport (GO:0048490)2.34542913
155signal transduction involved in DNA integrity checkpoint (GO:0072401)2.34532727
156signal transduction involved in DNA damage checkpoint (GO:0072422)2.34532727
157mitotic metaphase plate congression (GO:0007080)2.34181751
158tRNA aminoacylation (GO:0043039)2.33869346
159amino acid activation (GO:0043038)2.33869346
160histone H2A acetylation (GO:0043968)2.32961655
161regulation of nuclear cell cycle DNA replication (GO:0033262)2.32056024
162cornea development in camera-type eye (GO:0061303)2.31850220
163tRNA aminoacylation for protein translation (GO:0006418)2.30667570
164protein-cofactor linkage (GO:0018065)2.30625376
165histone mRNA metabolic process (GO:0008334)2.30612175
166detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.29647482
167L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.29472574
168regulation of cellular amino acid metabolic process (GO:0006521)2.29250243
169DNA strand renaturation (GO:0000733)2.28913178
170telomere maintenance via telomerase (GO:0007004)2.28719847
171postreplication repair (GO:0006301)2.28425721
172L-serine metabolic process (GO:0006563)2.26376980
173ganglion development (GO:0061548)2.25527797
174nucleotide-excision repair, DNA gap filling (GO:0006297)2.25209464
175resolution of meiotic recombination intermediates (GO:0000712)2.23884291
176spindle checkpoint (GO:0031577)2.23258873
177chromatin remodeling at centromere (GO:0031055)2.22133616
178regulation of cilium movement (GO:0003352)2.21557520
179keratinocyte development (GO:0003334)2.21299339
180CENP-A containing nucleosome assembly (GO:0034080)2.19889600
181branched-chain amino acid catabolic process (GO:0009083)2.19300531
182neural tube formation (GO:0001841)2.18628421
183maturation of 5.8S rRNA (GO:0000460)2.17854776
184regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.17774324
185mannosylation (GO:0097502)2.17154608
186negative regulation of keratinocyte proliferation (GO:0010839)2.15634354
187mitotic sister chromatid segregation (GO:0000070)2.14869390
188ventricular cardiac muscle cell development (GO:0055015)2.14440667
189limb bud formation (GO:0060174)2.14118805
190DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.14079205
191microtubule anchoring (GO:0034453)2.13750126
192double-strand break repair (GO:0006302)2.13725136
193fibroblast migration (GO:0010761)2.13043810
194cilium assembly (GO:0042384)2.12500655
195pseudouridine synthesis (GO:0001522)2.12137434
196regulation of integrin-mediated signaling pathway (GO:2001044)2.11905427
197negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.11866538
198negative regulation of ligase activity (GO:0051352)2.11866538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.99920966
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.97537895
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.45375264
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.83781828
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71825775
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.60196493
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.59056374
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.57346707
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04342216
10SALL1_21062744_ChIP-ChIP_HESCs_Human3.03572101
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92484270
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89644325
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.84147767
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.82377010
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80129737
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.75232274
17GBX2_23144817_ChIP-Seq_PC3_Human2.68101022
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67152702
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.65948025
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58248641
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.57681278
22FUS_26573619_Chip-Seq_HEK293_Human2.52356604
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48808648
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45540628
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40109262
26ZNF274_21170338_ChIP-Seq_K562_Hela2.33626580
27EWS_26573619_Chip-Seq_HEK293_Human2.31990262
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30471443
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23336835
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21692200
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21633674
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14037868
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.11485882
34VDR_22108803_ChIP-Seq_LS180_Human2.09891676
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08290025
36SPI1_23547873_ChIP-Seq_NB4_Human2.07402647
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05844796
38IGF1R_20145208_ChIP-Seq_DFB_Human2.01516326
39MYB_26560356_Chip-Seq_TH2_Human1.96639822
40TAF15_26573619_Chip-Seq_HEK293_Human1.95067262
41P300_19829295_ChIP-Seq_ESCs_Human1.91604260
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86207004
43MYC_22102868_ChIP-Seq_BL_Human1.81411062
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81153636
45SCL_19346495_ChIP-Seq_HPC-7_Human1.80676800
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.76801752
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76473079
48VDR_21846776_ChIP-Seq_THP-1_Human1.74315915
49MYB_26560356_Chip-Seq_TH1_Human1.72756471
50* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69124152
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68833672
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.68589682
53MAF_26560356_Chip-Seq_TH1_Human1.66505719
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.64424787
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63673077
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63609258
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61833583
58ER_23166858_ChIP-Seq_MCF-7_Human1.61035216
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.58577377
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.56278852
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56223554
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.56126265
63VDR_24763502_ChIP-Seq_THP-1_Human1.55328973
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54856457
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54364773
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52729588
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51445554
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50680240
69AR_21909140_ChIP-Seq_LNCAP_Human1.49244689
70SMAD4_21799915_ChIP-Seq_A2780_Human1.49101251
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49034316
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45261581
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43245868
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43212648
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43082105
76ELK1_19687146_ChIP-ChIP_HELA_Human1.40349739
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38693276
78PU_27001747_Chip-Seq_BMDM_Mouse1.38404130
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38383938
80BRD4_25478319_ChIP-Seq_HGPS_Human1.37941929
81TP53_18474530_ChIP-ChIP_U2OS_Human1.37072892
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35917326
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35674274
84CBP_20019798_ChIP-Seq_JUKART_Human1.35151059
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35151059
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33896198
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33493444
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32958770
89UTX_26944678_Chip-Seq_JUKART_Human1.32824652
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31471033
91RUNX_20019798_ChIP-Seq_JUKART_Human1.31189771
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30277475
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30233883
94MYC_18940864_ChIP-ChIP_HL60_Human1.28620359
95STAT3_23295773_ChIP-Seq_U87_Human1.27201953
96ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26376113
97SPI1_23127762_ChIP-Seq_K562_Human1.26325648
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.23748016
99AR_25329375_ChIP-Seq_VCAP_Human1.23206660
100ETS1_20019798_ChIP-Seq_JURKAT_Human1.22868009
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22851672
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22638138
103GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22585021
104TP63_17297297_ChIP-ChIP_HaCaT_Human1.22189016
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22166904
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.21389368
107TFEB_21752829_ChIP-Seq_HELA_Human1.20738658
108CJUN_26792858_Chip-Seq_BT549_Human1.20708575
109ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20462588
110DCP1A_22483619_ChIP-Seq_HELA_Human1.18463992
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17682779
112JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17286056
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17267521
114CDX2_22108803_ChIP-Seq_LS180_Human1.17155232
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16222301
116GATA1_22025678_ChIP-Seq_K562_Human1.14953132
117MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14611366
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14311105
119TP53_16413492_ChIP-PET_HCT116_Human1.13899697
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13371607
121TCF7_22412390_ChIP-Seq_EML_Mouse1.12601635
122MYC_18555785_ChIP-Seq_MESCs_Mouse1.12546619
123WT1_19549856_ChIP-ChIP_CCG9911_Human1.11302062
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11030959
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10505577
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09815660
127SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.09632878
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08944590
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08874655
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08322421
131NANOG_18555785_Chip-Seq_ESCs_Mouse1.07731950
132VDR_23849224_ChIP-Seq_CD4+_Human1.06180274
133GATA3_27048872_Chip-Seq_THYMUS_Human1.06153664
134TCF4_23295773_ChIP-Seq_U87_Human1.06144784
135TCF4_22108803_ChIP-Seq_LS180_Human1.05716509
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05359834
137CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05313858
138NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03909897
139JUN_21703547_ChIP-Seq_K562_Human1.03416235
140NFE2_27457419_Chip-Seq_LIVER_Mouse1.02876216
141OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02800162
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02750932
143NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02750932
144FLI1_21867929_ChIP-Seq_TH2_Mouse1.02331840
145PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00258736
146BCAT_22108803_ChIP-Seq_LS180_Human0.99413647
147POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98740386
148NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98599884
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98258956
150TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97419633
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97342619
152STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94995243
153LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94850148
154GATA3_26560356_Chip-Seq_TH2_Human0.94440242
155E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94361003
156FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92466192
157GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92119947
158FOXP3_21729870_ChIP-Seq_TREG_Human0.89903671
159STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88528511
160MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88500536
161MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86272495
162MAF_26560356_Chip-Seq_TH2_Human0.85709153
163KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85074450
164EST1_17652178_ChIP-ChIP_JURKAT_Human0.84204912
165NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82889902
166CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82184133
167TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81932255
168CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81094834
169CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81028280
170CIITA_25753668_ChIP-Seq_RAJI_Human0.80368037
171RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80337650
172TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79485293
173MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.79470608
174PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78076946
175VDR_24787735_ChIP-Seq_THP-1_Human0.77480596
176PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75948172
177ELK3_25401928_ChIP-Seq_HUVEC_Human0.75276685
178RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75217729
179E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75095666
180KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.74958853
181MYC_19079543_ChIP-ChIP_MESCs_Mouse0.74190229
182SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.74177431
183SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.74177431
184PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74064553
185NOTCH1_21737748_ChIP-Seq_TLL_Human0.72709040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.10505943
2MP0000372_irregular_coat_pigmentation3.20875827
3MP0002102_abnormal_ear_morphology3.08396493
4MP0000685_abnormal_immune_system2.92613812
5MP0009785_altered_susceptibility_to2.92429492
6MP0003436_decreased_susceptibility_to2.85308391
7MP0005000_abnormal_immune_tolerance2.68498177
8MP0002148_abnormal_hypersensitivity_rea2.66602666
9MP0006082_CNS_inflammation2.62094532
10MP0001800_abnormal_humoral_immune2.58218064
11MP0003950_abnormal_plasma_membrane2.55729194
12MP0005387_immune_system_phenotype2.53921441
13MP0001790_abnormal_immune_system2.53921441
14MP0002452_abnormal_antigen_presenting2.50431358
15MP0005671_abnormal_response_to2.50250196
16MP0002419_abnormal_innate_immunity2.50179677
17MP0002396_abnormal_hematopoietic_system2.40974692
18MP0005025_abnormal_response_to2.40770647
19MP0000569_abnormal_digit_pigmentation2.35281660
20MP0002938_white_spotting2.32065521
21MP0002723_abnormal_immune_serum2.31646081
22MP0010094_abnormal_chromosome_stability2.25207659
23MP0001819_abnormal_immune_cell2.23621828
24MP0002420_abnormal_adaptive_immunity2.22708900
25MP0002234_abnormal_pharynx_morphology2.11256951
26MP0005187_abnormal_penis_morphology2.08611638
27MP0002166_altered_tumor_susceptibility2.07326848
28MP0003303_peritoneal_inflammation2.07210208
29MP0010307_abnormal_tumor_latency2.07080290
30MP0002398_abnormal_bone_marrow2.03039537
31MP0002006_tumorigenesis2.01156700
32MP0008057_abnormal_DNA_replication1.98821436
33MP0005464_abnormal_platelet_physiology1.92478965
34MP0009697_abnormal_copulation1.92059582
35MP0003763_abnormal_thymus_physiology1.90194722
36MP0004808_abnormal_hematopoietic_stem1.85554041
37MP0002405_respiratory_system_inflammati1.84614280
38MP0000716_abnormal_immune_system1.82985012
39MP0003937_abnormal_limbs/digits/tail_de1.82519713
40MP0001545_abnormal_hematopoietic_system1.80462376
41MP0005397_hematopoietic_system_phenotyp1.80462376
42MP0009278_abnormal_bone_marrow1.79582988
43MP0004947_skin_inflammation1.78340251
44MP0001853_heart_inflammation1.76848426
45MP0006072_abnormal_retinal_apoptosis1.71929803
46MP0008877_abnormal_DNA_methylation1.71910152
47MP0003724_increased_susceptibility_to1.69321572
48MP0003693_abnormal_embryo_hatching1.68441425
49MP0000689_abnormal_spleen_morphology1.67168724
50MP0010155_abnormal_intestine_physiology1.64669131
51MP0003111_abnormal_nucleus_morphology1.64646687
52MP0003880_abnormal_central_pattern1.64432929
53MP0005171_absent_coat_pigmentation1.63324155
54MP0002722_abnormal_immune_system1.62938088
55MP0005551_abnormal_eye_electrophysiolog1.62416600
56MP0009333_abnormal_splenocyte_physiolog1.62233215
57MP0005408_hypopigmentation1.60661449
58MP0003077_abnormal_cell_cycle1.59600754
59MP0010352_gastrointestinal_tract_polyps1.58466556
60MP0002429_abnormal_blood_cell1.58247752
61MP0003300_gastrointestinal_ulcer1.56597411
62MP0003448_altered_tumor_morphology1.54373338
63MP0001845_abnormal_inflammatory_respons1.52932100
64MP0000490_abnormal_crypts_of1.51580654
65MP0002233_abnormal_nose_morphology1.50000225
66MP0003195_calcinosis1.49245801
67MP0005253_abnormal_eye_physiology1.48189294
68MP0005367_renal/urinary_system_phenotyp1.47732845
69MP0000516_abnormal_urinary_system1.47732845
70MP0000647_abnormal_sebaceous_gland1.47476028
71MP0003755_abnormal_palate_morphology1.47474979
72MP0000858_altered_metastatic_potential1.47295423
73MP0004510_myositis1.46931047
74MP0001533_abnormal_skeleton_physiology1.44520849
75MP0000427_abnormal_hair_cycle1.42292757
76MP0002282_abnormal_trachea_morphology1.41903147
77MP0001984_abnormal_olfaction1.38510194
78MP0001529_abnormal_vocalization1.37716368
79MP0005076_abnormal_cell_differentiation1.34749805
80MP0004272_abnormal_basement_membrane1.33953753
81MP0002751_abnormal_autonomic_nervous1.33683385
82MP0000703_abnormal_thymus_morphology1.32829250
83MP0003172_abnormal_lysosome_physiology1.32548351
84MP0005174_abnormal_tail_pigmentation1.32071476
85MP0006054_spinal_hemorrhage1.31883824
86MP0001293_anophthalmia1.30806396
87MP0003566_abnormal_cell_adhesion1.30391946
88MP0003718_maternal_effect1.29538841
89MP0008007_abnormal_cellular_replicative1.27573942
90MP0005058_abnormal_lysosome_morphology1.26997949
91MP0005310_abnormal_salivary_gland1.24504877
92MP0010030_abnormal_orbit_morphology1.22516523
93MP0009250_abnormal_appendicular_skeleto1.21015571
94MP0001299_abnormal_eye_distance/1.18548984
95MP0003385_abnormal_body_wall1.18462960
96MP0002177_abnormal_outer_ear1.17023293
97MP0010678_abnormal_skin_adnexa1.17008454
98MP0001324_abnormal_eye_pigmentation1.16012430
99MP0008789_abnormal_olfactory_epithelium1.15259976
100MP0000465_gastrointestinal_hemorrhage1.15250239
101MP0002090_abnormal_vision1.15219057
102MP0008469_abnormal_protein_level1.14462789
103MP0001348_abnormal_lacrimal_gland1.13405074
104MP0002019_abnormal_tumor_incidence1.12992994
105MP0003186_abnormal_redox_activity1.10259080
106MP0005248_abnormal_Harderian_gland1.09921809
107MP0000015_abnormal_ear_pigmentation1.09678165
108MP0004957_abnormal_blastocyst_morpholog1.08043084
109MP0003136_yellow_coat_color1.07566142
110MP0003786_premature_aging1.06821865
111MP0004133_heterotaxia1.06471190
112MP0006276_abnormal_autonomic_nervous1.06286556
113MP0009780_abnormal_chondrocyte_physiolo1.05949257
114MP0003943_abnormal_hepatobiliary_system1.05318589
115MP0003941_abnormal_skin_development1.04614492
116MP0001879_abnormal_lymphatic_vessel1.03502050
117MP0002736_abnormal_nociception_after1.02819652
118MP0003091_abnormal_cell_migration1.02802352
119MP0002928_abnormal_bile_duct1.02735420
120MP0001873_stomach_inflammation1.02477275
121MP0009764_decreased_sensitivity_to1.02166448
122MP0005623_abnormal_meninges_morphology1.01560710
123MP0009053_abnormal_anal_canal1.01082802
124MP0002877_abnormal_melanocyte_morpholog1.01008680
125MP0003806_abnormal_nucleotide_metabolis1.00953295
126MP0003121_genomic_imprinting1.00930525
127MP0002933_joint_inflammation1.00271596
128MP0003935_abnormal_craniofacial_develop0.99497938
129MP0005023_abnormal_wound_healing0.98280955
130MP0002160_abnormal_reproductive_system0.98028228
131MP0000538_abnormal_urinary_bladder0.96767268
132MP0008438_abnormal_cutaneous_collagen0.95911612
133MP0000343_altered_response_to0.94836858
134MP0008058_abnormal_DNA_repair0.94744745
135MP0000383_abnormal_hair_follicle0.94509221
136MP0003315_abnormal_perineum_morphology0.93818399
137MP0000350_abnormal_cell_proliferation0.92577271
138MP0000631_abnormal_neuroendocrine_gland0.90370947
139MP0005395_other_phenotype0.90137941
140MP0005391_vision/eye_phenotype0.90032499
141MP0005084_abnormal_gallbladder_morpholo0.89120372
142MP0002998_abnormal_bone_remodeling0.89051315
143MP0000613_abnormal_salivary_gland0.88590251
144MP0003890_abnormal_embryonic-extraembry0.88388126
145MP0005195_abnormal_posterior_eye0.87835043
146MP0000371_diluted_coat_color0.87062615
147MP0009763_increased_sensitivity_to0.86421898
148MP0001915_intracranial_hemorrhage0.86174875
149MP0000778_abnormal_nervous_system0.85821822
150MP0000313_abnormal_cell_death0.85625498
151MP0003705_abnormal_hypodermis_morpholog0.85404789
152MP0005389_reproductive_system_phenotype0.84824278
153MP0002084_abnormal_developmental_patter0.84612817
154MP0010234_abnormal_vibrissa_follicle0.83024814
155MP0001286_abnormal_eye_development0.82983908
156MP0002163_abnormal_gland_morphology0.82808498
157MP0002210_abnormal_sex_determination0.82348695
158MP0003828_pulmonary_edema0.82034532
159MP0005197_abnormal_uvea_morphology0.80550803
160MP0006292_abnormal_olfactory_placode0.80526068
161MP0003119_abnormal_digestive_system0.79821919
162MP0001764_abnormal_homeostasis0.78985357
163MP0002168_other_aberrant_phenotype0.78416182
164MP0000653_abnormal_sex_gland0.77635750
165MP0004134_abnormal_chest_morphology0.77124203
166MP0002075_abnormal_coat/hair_pigmentati0.76558610
167MP0002697_abnormal_eye_size0.76516734
168MP0000358_abnormal_cell_content/0.76033924
169MP0003787_abnormal_imprinting0.75868518
170MP0002085_abnormal_embryonic_tissue0.75817233
171MP0000432_abnormal_head_morphology0.74534557
172MP0005390_skeleton_phenotype0.73473761
173MP0005621_abnormal_cell_physiology0.72946257
174MP0002095_abnormal_skin_pigmentation0.72118063
175MP0003279_aneurysm0.68042389
176MP0003866_abnormal_defecation0.67580678
177MP0000767_abnormal_smooth_muscle0.67144566
178MP0000249_abnormal_blood_vessel0.66360580
179MP0001243_abnormal_dermal_layer0.65010299
180MP0000733_abnormal_muscle_development0.64067868
181MP0003191_abnormal_cellular_cholesterol0.63097040
182MP0003453_abnormal_keratinocyte_physiol0.58800032
183MP0003075_altered_response_to0.55427370
184MP0008932_abnormal_embryonic_tissue0.53416220
185MP0001346_abnormal_lacrimal_gland0.53322352

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.19478770
2Recurrent bacterial skin infections (HP:0005406)4.58885941
3Autoimmune thrombocytopenia (HP:0001973)4.42252115
4Eczematoid dermatitis (HP:0000976)4.19492712
5Elevated erythrocyte sedimentation rate (HP:0003565)4.13705052
6Myositis (HP:0100614)4.10969890
7Recurrent viral infections (HP:0004429)3.77317157
8True hermaphroditism (HP:0010459)3.70954001
9Recurrent fungal infections (HP:0002841)3.54968542
10Optic neuritis (HP:0100653)3.48717927
11Retrobulbar optic neuritis (HP:0100654)3.48717927
12Orchitis (HP:0100796)3.42840104
13Pancreatic fibrosis (HP:0100732)3.35449096
14Mediastinal lymphadenopathy (HP:0100721)3.28255602
15Abnormality of T cell number (HP:0011839)3.26333308
16Pancreatic cysts (HP:0001737)3.23479511
17Osteolytic defects of the hand bones (HP:0009699)3.12832823
18Osteolytic defects of the phalanges of the hand (HP:0009771)3.12832823
19Vasculitis (HP:0002633)3.07040672
20Abnormality of midbrain morphology (HP:0002418)3.07036443
21Molar tooth sign on MRI (HP:0002419)3.07036443
22Eosinophilia (HP:0001880)3.05916672
23Cellulitis (HP:0100658)3.00196490
24Increased IgM level (HP:0003496)2.97101784
25Recurrent skin infections (HP:0001581)2.94286093
26Aplasia/Hypoplasia of the tongue (HP:0010295)2.90662096
27Recurrent gram-negative bacterial infections (HP:0005420)2.87787955
28Syringomyelia (HP:0003396)2.86735941
29Spinal cord lesions (HP:0100561)2.86735941
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.85545157
31Abnormality of macrophages (HP:0004311)2.82256751
32Agnosia (HP:0010524)2.77186913
33Occipital encephalocele (HP:0002085)2.76386203
34T lymphocytopenia (HP:0005403)2.75771167
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.74916359
36Leukocytosis (HP:0001974)2.74661745
37Thrombocytosis (HP:0001894)2.74135368
38Absent frontal sinuses (HP:0002688)2.73011382
39Periodontitis (HP:0000704)2.71903784
40Abnormality of T cells (HP:0002843)2.71825649
41Chronic hepatic failure (HP:0100626)2.70701902
42Granulocytopenia (HP:0001913)2.67734512
43Chromsome breakage (HP:0040012)2.67124048
44Gingivitis (HP:0000230)2.66118603
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.66008977
46Obstructive lung disease (HP:0006536)2.65736581
47Chronic obstructive pulmonary disease (HP:0006510)2.65736581
48Meningitis (HP:0001287)2.63772626
49Basal ganglia calcification (HP:0002135)2.63506282
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.63135507
51IgM deficiency (HP:0002850)2.62369200
52Recurrent bronchitis (HP:0002837)2.60024808
53Abnormality of T cell physiology (HP:0011840)2.59987631
54Chronic otitis media (HP:0000389)2.59820604
55Medial flaring of the eyebrow (HP:0010747)2.59582922
56Osteomyelitis (HP:0002754)2.59294691
57Abnormality of the labia minora (HP:0012880)2.58992810
58IgA deficiency (HP:0002720)2.55228088
59Chronic mucocutaneous candidiasis (HP:0002728)2.54787110
60Recurrent cutaneous fungal infections (HP:0011370)2.54787110
61Increased cerebral lipofuscin (HP:0011813)2.52511593
62Thyroiditis (HP:0100646)2.52028347
63Autoimmune hemolytic anemia (HP:0001890)2.51230110
64Abnormality of eosinophils (HP:0001879)2.50103631
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.48256276
66Prostate neoplasm (HP:0100787)2.47864837
67B lymphocytopenia (HP:0010976)2.47153184
68Abnormality of B cell number (HP:0010975)2.47153184
69IgG deficiency (HP:0004315)2.46868185
70Abnormality of the prostate (HP:0008775)2.45820071
71Stomatitis (HP:0010280)2.44865810
72Bifid tongue (HP:0010297)2.44423878
73Birth length less than 3rd percentile (HP:0003561)2.43511923
74Petechiae (HP:0000967)2.41428385
75Lymphopenia (HP:0001888)2.40484480
76Meckel diverticulum (HP:0002245)2.39930602
77Severe combined immunodeficiency (HP:0004430)2.39321762
78Keratoconjunctivitis sicca (HP:0001097)2.38765462
79Abnormal lung lobation (HP:0002101)2.38302987
80Pustule (HP:0200039)2.37945533
81Combined immunodeficiency (HP:0005387)2.37422561
82Hypergammaglobulinemia (HP:0010702)2.35325448
83Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34957225
84Abnormality of the ileum (HP:0001549)2.34669893
85Recurrent pneumonia (HP:0006532)2.33704209
86Neoplasm of the adrenal cortex (HP:0100641)2.32207944
87Abnormal platelet volume (HP:0011876)2.31323721
88Vacuolated lymphocytes (HP:0001922)2.30652419
89Cystic liver disease (HP:0006706)2.30153327
90Astrocytoma (HP:0009592)2.29797749
91Abnormality of the astrocytes (HP:0100707)2.29797749
92Arterial thrombosis (HP:0004420)2.28324027
93Duodenal stenosis (HP:0100867)2.28110510
94Small intestinal stenosis (HP:0012848)2.28110510
95Small hand (HP:0200055)2.26415384
96Type II lissencephaly (HP:0007260)2.25361238
97Agammaglobulinemia (HP:0004432)2.25193714
98Panhypogammaglobulinemia (HP:0003139)2.24488182
99Recurrent lower respiratory tract infections (HP:0002783)2.21771399
100Sloping forehead (HP:0000340)2.21148585
101Disinhibition (HP:0000734)2.20518847
102Congenital primary aphakia (HP:0007707)2.19703738
103Pulmonary infiltrates (HP:0002113)2.19073823
104Abnormality of chromosome stability (HP:0003220)2.18920177
105Nephronophthisis (HP:0000090)2.18189714
106Abnormality of the fingertips (HP:0001211)2.16121899
107Postaxial foot polydactyly (HP:0001830)2.15030678
108Preaxial hand polydactyly (HP:0001177)2.14215202
109Glioma (HP:0009733)2.14139862
110Short tibia (HP:0005736)2.13987227
111Keratoconjunctivitis (HP:0001096)2.11864963
112Hypoplasia of the thymus (HP:0000778)2.11648308
113Gait imbalance (HP:0002141)2.11570870
114Abnormality of macular pigmentation (HP:0008002)2.10364151
115Anencephaly (HP:0002323)2.09825423
116Lymphoma (HP:0002665)2.08836414
117Sclerocornea (HP:0000647)2.08818734
118Dandy-Walker malformation (HP:0001305)2.08498807
119Microglossia (HP:0000171)2.08416764
120Abnormality of the preputium (HP:0100587)2.07727485
121Genital tract atresia (HP:0001827)2.07697458
122Increased mean platelet volume (HP:0011877)2.05009721
123Encephalitis (HP:0002383)2.02915823
124Interstitial pulmonary disease (HP:0006530)2.01677887
125Leukopenia (HP:0001882)2.01473713
126Astigmatism (HP:0000483)2.00360483
127Abnormality of the duodenum (HP:0002246)1.99675963
128Abnormality of the renal cortex (HP:0011035)1.98999890
129Short middle phalanx of the 5th finger (HP:0004220)1.98817084
130Nephrogenic diabetes insipidus (HP:0009806)1.98398112
131Urticaria (HP:0001025)1.98293741
132Hemoptysis (HP:0002105)1.98077855
133Abnormality of the renal medulla (HP:0100957)1.97744584
134Delayed gross motor development (HP:0002194)1.97590757
135Volvulus (HP:0002580)1.96794485
136Papilledema (HP:0001085)1.96676368
137Myelodysplasia (HP:0002863)1.96171973
138Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.95837018
139Clubbing of toes (HP:0100760)1.94019281
140Prolonged bleeding time (HP:0003010)1.91854823
141Hypochromic anemia (HP:0001931)1.91813865
142Oligodactyly (hands) (HP:0001180)1.90811879
143Thick nail (HP:0001805)1.90193246
144Abnormality of the pleura (HP:0002103)1.89627131
145Skin ulcer (HP:0200042)1.89457210
146Sepsis (HP:0100806)1.89337617
147Spontaneous hematomas (HP:0007420)1.89318299
148Vaginal atresia (HP:0000148)1.88851246
149Poor head control (HP:0002421)1.87530411
150Hypoplastic labia majora (HP:0000059)1.85216687
151Median cleft lip (HP:0000161)1.84907151
152Congenital stationary night blindness (HP:0007642)1.84860492
153Aplasia/Hypoplasia of the fovea (HP:0008060)1.84351002
154Hypoplasia of the fovea (HP:0007750)1.84351002
155Amniotic constriction ring (HP:0009775)1.84285762
156Abnormality of placental membranes (HP:0011409)1.84285762
157Stenosis of the external auditory canal (HP:0000402)1.81711171
158Adrenal hypoplasia (HP:0000835)1.80756724
159Abnormality of methionine metabolism (HP:0010901)1.79364254
160Ectopic kidney (HP:0000086)1.77203506
161Albinism (HP:0001022)1.77006407
162Postaxial hand polydactyly (HP:0001162)1.76869324
163Increased CSF lactate (HP:0002490)1.76816227
164Intestinal atresia (HP:0011100)1.75531348
165Aganglionic megacolon (HP:0002251)1.75458416
166Abnormal biliary tract physiology (HP:0012439)1.73522685
167Bile duct proliferation (HP:0001408)1.73522685
168Triphalangeal thumb (HP:0001199)1.72472525
169Furrowed tongue (HP:0000221)1.71679956
170Labial hypoplasia (HP:0000066)1.71357783
171Hypoplastic female external genitalia (HP:0012815)1.71224992
172Cerebellar dysplasia (HP:0007033)1.71130675
173Male pseudohermaphroditism (HP:0000037)1.71017999
174Acute necrotizing encephalopathy (HP:0006965)1.70275699
175Lissencephaly (HP:0001339)1.69206332
176Acute encephalopathy (HP:0006846)1.67174895
177Renal cortical cysts (HP:0000803)1.66876362
178Abnormality of the anterior horn cell (HP:0006802)1.66317318
179Degeneration of anterior horn cells (HP:0002398)1.66317318
180Gastrointestinal atresia (HP:0002589)1.65265643
181Breast carcinoma (HP:0003002)1.65136060
182Progressive macrocephaly (HP:0004481)1.64923656
183Supernumerary spleens (HP:0009799)1.64762242
184Hyperventilation (HP:0002883)1.64513947
185Oligodactyly (HP:0012165)1.64163576
186Ependymoma (HP:0002888)1.63601042
187Retinal dysplasia (HP:0007973)1.63343342
188Colon cancer (HP:0003003)1.63249404
189Oculomotor apraxia (HP:0000657)1.61409301
190Abnormality of the labia majora (HP:0012881)1.60859608
191Embryonal renal neoplasm (HP:0011794)1.60442190
192Absent speech (HP:0001344)1.59657205
193Gaze-evoked nystagmus (HP:0000640)1.59277564
194Nephroblastoma (Wilms tumor) (HP:0002667)1.59267534
195Abnormality of the fovea (HP:0000493)1.59176938
196Narrow forehead (HP:0000341)1.58377392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.28896396
2MAP3K143.49488820
3MAP4K13.39323263
4TRIM283.17986526
5WNK32.69112996
6EIF2AK32.68485976
7TYK22.41747227
8CDC72.41446102
9KIT2.36024155
10IRAK42.34655060
11TXK2.31545985
12BMPR1B2.22806592
13JAK32.15583795
14TBK12.11379924
15PIM22.06353715
16STK38L1.98953767
17BLK1.98905251
18TNIK1.93096478
19NUAK11.91776634
20NEK91.89104342
21MKNK21.87242119
22PLK31.85032419
23STK101.85022612
24PLK21.78796602
25RPS6KA41.78792224
26CSF1R1.74678674
27PNCK1.71763589
28IKBKE1.70029419
29TEC1.68876175
30NEK11.68091354
31CASK1.67086256
32TRPM71.66758749
33NEK21.65855227
34NME21.63258608
35IKBKB1.59568602
36SIK31.56243720
37MAP3K101.55154109
38RIPK41.54615765
39STK41.53285822
40PIM11.51214826
41SYK1.51043226
42BTK1.50824257
43ZAP701.49540675
44TTN1.48723506
45STK391.48210181
46CDK121.43833099
47JAK11.41179251
48BUB11.36909281
49MAP3K121.36038566
50IRAK31.33231981
51PAK31.33209537
52CDK61.32566589
53MKNK11.31856653
54TSSK61.29947631
55TTK1.29282369
56WEE11.26472203
57SCYL21.26123532
58CHUK1.24058944
59MET1.22829399
60GRK11.21787006
61PBK1.21766728
62LRRK21.21214036
63HCK1.21167230
64ATR1.18018372
65MAP2K31.17963626
66MST1R1.17312238
67STK241.17026615
68TIE11.16982798
69ITK1.15094811
70MAP4K21.14672069
71STK161.13626704
72MAPK131.13191402
73FLT31.12916899
74FER1.11021238
75BRSK21.11015339
76ACVR1B1.10971082
77CDK41.06207817
78CLK11.05168102
79CSNK1G11.03769835
80LYN1.03165075
81CSK1.02231727
82LCK1.02181313
83EIF2AK10.99715238
84MARK10.98854924
85AURKB0.94457812
86ADRBK20.94125519
87PKN20.92794221
88ERN10.91414508
89TAOK30.91311860
90ZAK0.90696947
91OXSR10.90588101
92TLK10.90146949
93EIF2AK20.89963732
94PINK10.89550425
95CSNK1G20.88721982
96WNK40.86516866
97CSNK1G30.86237640
98PLK40.85753040
99MAP3K80.85383742
100CSNK1A1L0.84238067
101CHEK20.83508528
102CDK80.83247101
103EEF2K0.80638134
104TGFBR10.78929795
105STK30.78333090
106MAP3K40.78217134
107MINK10.78209580
108BRSK10.77385720
109TESK20.75705471
110MAP3K130.74548761
111MARK30.72969383
112LATS10.70182532
113FGFR30.70068375
114MUSK0.68449573
115PRKCE0.68370748
116GRK60.67779348
117PLK10.67751580
118LIMK10.67217820
119PDK20.66342911
120TESK10.66142924
121TAF10.64156706
122VRK20.63262247
123DYRK20.62522843
124KDR0.62129706
125MAPKAPK20.61406756
126BMX0.61154332
127ERBB30.60985463
128TGFBR20.58857218
129MYLK0.58457400
130MAPKAPK50.57090694
131FES0.56571985
132YES10.56312539
133EPHA20.55387115
134EPHA40.55354238
135MAP2K70.55340975
136ABL10.54339367
137DYRK30.53903262
138ADRBK10.52568349
139ERBB40.52349638
140AKT30.51794754
141BCR0.51758955
142RPS6KA60.51598011
143ROCK10.51129051
144BRD40.50661636
145INSRR0.50478819
146ATM0.50446401
147MST40.48946116
148PTK2B0.48590829
149RPS6KB20.48410784
150CDK70.48190313
151MATK0.47560300
152EGFR0.47335608
153VRK10.45848390
154CCNB10.45444440
155PRKCQ0.44785349
156PTK60.44565417
157CHEK10.44004687
158SRPK10.43569345
159PAK40.43453030
160JAK20.42987280
161MAP3K50.42499194
162EPHB20.42160244
163DYRK1B0.42068369
164PRKCD0.42032725
165PRKCG0.39678855
166RPS6KC10.39660760
167KSR10.37604169
168MAPKAPK30.35467916
169PRKCI0.34585867
170PKN10.34307809
171FGFR10.33725513
172CSNK2A10.30658740

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.74964614
2DNA replication_Homo sapiens_hsa030302.91513807
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48995670
4Allograft rejection_Homo sapiens_hsa053302.42876319
5Leishmaniasis_Homo sapiens_hsa051402.36085414
6Mismatch repair_Homo sapiens_hsa034302.34124931
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.29654313
8Basal transcription factors_Homo sapiens_hsa030222.28771452
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25771181
10Graft-versus-host disease_Homo sapiens_hsa053322.23600879
11Primary immunodeficiency_Homo sapiens_hsa053402.22445414
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16169143
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.11545993
14Measles_Homo sapiens_hsa051622.10639867
15Selenocompound metabolism_Homo sapiens_hsa004502.04966576
16Propanoate metabolism_Homo sapiens_hsa006402.03052727
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02043905
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98348312
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97757164
20RNA polymerase_Homo sapiens_hsa030201.92941146
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82986772
22Legionellosis_Homo sapiens_hsa051341.80561465
23Base excision repair_Homo sapiens_hsa034101.77609889
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77317596
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76345879
26Homologous recombination_Homo sapiens_hsa034401.71801037
27Antigen processing and presentation_Homo sapiens_hsa046121.71025482
28Osteoclast differentiation_Homo sapiens_hsa043801.69668861
29Herpes simplex infection_Homo sapiens_hsa051681.69170267
30B cell receptor signaling pathway_Homo sapiens_hsa046621.62791596
31Hematopoietic cell lineage_Homo sapiens_hsa046401.62789504
32Non-homologous end-joining_Homo sapiens_hsa034501.60279725
33Influenza A_Homo sapiens_hsa051641.56778340
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55097856
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.54352539
36Steroid biosynthesis_Homo sapiens_hsa001001.53428946
37Apoptosis_Homo sapiens_hsa042101.51895842
38Shigellosis_Homo sapiens_hsa051311.51512419
39p53 signaling pathway_Homo sapiens_hsa041151.51054379
40Pertussis_Homo sapiens_hsa051331.51005643
41Autoimmune thyroid disease_Homo sapiens_hsa053201.50924383
42Viral myocarditis_Homo sapiens_hsa054161.50742818
43* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50244315
44Butanoate metabolism_Homo sapiens_hsa006501.50025863
45Cell cycle_Homo sapiens_hsa041101.47527368
46Tuberculosis_Homo sapiens_hsa051521.45103141
47Malaria_Homo sapiens_hsa051441.43948821
48Fatty acid elongation_Homo sapiens_hsa000621.40221387
49Vitamin B6 metabolism_Homo sapiens_hsa007501.39252538
50Hepatitis B_Homo sapiens_hsa051611.39139403
51Toxoplasmosis_Homo sapiens_hsa051451.38366395
52TNF signaling pathway_Homo sapiens_hsa046681.38279413
53Asthma_Homo sapiens_hsa053101.35313276
54One carbon pool by folate_Homo sapiens_hsa006701.33519618
55Type I diabetes mellitus_Homo sapiens_hsa049401.27863418
56Oxidative phosphorylation_Homo sapiens_hsa001901.26498693
57Phototransduction_Homo sapiens_hsa047441.26441045
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.25345757
59Fanconi anemia pathway_Homo sapiens_hsa034601.24886701
60Salmonella infection_Homo sapiens_hsa051321.20228376
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18090624
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17666535
63Glutathione metabolism_Homo sapiens_hsa004801.17265347
64Systemic lupus erythematosus_Homo sapiens_hsa053221.15460321
65Viral carcinogenesis_Homo sapiens_hsa052031.14873418
66Parkinsons disease_Homo sapiens_hsa050121.13610933
67Staphylococcus aureus infection_Homo sapiens_hsa051501.12491295
68Small cell lung cancer_Homo sapiens_hsa052221.10771272
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10308379
70Nucleotide excision repair_Homo sapiens_hsa034201.09278723
71N-Glycan biosynthesis_Homo sapiens_hsa005101.08053299
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07741729
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07692505
74Chronic myeloid leukemia_Homo sapiens_hsa052201.05047367
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04900516
76Epstein-Barr virus infection_Homo sapiens_hsa051691.00867990
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00730840
78Huntingtons disease_Homo sapiens_hsa050161.00261177
79T cell receptor signaling pathway_Homo sapiens_hsa046600.98775126
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98485170
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98372410
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98122647
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.97658408
84Pyruvate metabolism_Homo sapiens_hsa006200.94910944
85Chemokine signaling pathway_Homo sapiens_hsa040620.93973472
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92798183
87Hedgehog signaling pathway_Homo sapiens_hsa043400.91577038
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91221703
89Lysosome_Homo sapiens_hsa041420.89992201
90Hippo signaling pathway_Homo sapiens_hsa043900.89275524
91Phagosome_Homo sapiens_hsa041450.88219906
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87221878
93Rheumatoid arthritis_Homo sapiens_hsa053230.86975313
94HTLV-I infection_Homo sapiens_hsa051660.86608999
95TGF-beta signaling pathway_Homo sapiens_hsa043500.86004520
96Pancreatic cancer_Homo sapiens_hsa052120.85879525
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85140084
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85043344
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84986023
100Purine metabolism_Homo sapiens_hsa002300.83805505
101MicroRNAs in cancer_Homo sapiens_hsa052060.83373213
102Spliceosome_Homo sapiens_hsa030400.82557687
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81255519
104Hepatitis C_Homo sapiens_hsa051600.81115485
105Platelet activation_Homo sapiens_hsa046110.80942784
106Basal cell carcinoma_Homo sapiens_hsa052170.79446139
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78811377
108Fatty acid metabolism_Homo sapiens_hsa012120.78557208
109Proteasome_Homo sapiens_hsa030500.77588214
110African trypanosomiasis_Homo sapiens_hsa051430.75795745
111Acute myeloid leukemia_Homo sapiens_hsa052210.73467711
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.72148549
113Olfactory transduction_Homo sapiens_hsa047400.71888449
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70938352
115Nitrogen metabolism_Homo sapiens_hsa009100.70634401
116Metabolic pathways_Homo sapiens_hsa011000.69365997
117RNA transport_Homo sapiens_hsa030130.69129165
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66185198
119Oocyte meiosis_Homo sapiens_hsa041140.66129442
120Sphingolipid metabolism_Homo sapiens_hsa006000.65402520
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65160072
122Tryptophan metabolism_Homo sapiens_hsa003800.64072373
123Pyrimidine metabolism_Homo sapiens_hsa002400.63101026
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62791060
125RNA degradation_Homo sapiens_hsa030180.61839570
126Folate biosynthesis_Homo sapiens_hsa007900.58024759
127Peroxisome_Homo sapiens_hsa041460.57691611
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.56182772
129Amoebiasis_Homo sapiens_hsa051460.55710984
130Circadian rhythm_Homo sapiens_hsa047100.54682493
131Alzheimers disease_Homo sapiens_hsa050100.54599899
132Other glycan degradation_Homo sapiens_hsa005110.54284195
133Proteoglycans in cancer_Homo sapiens_hsa052050.53464336
134Ether lipid metabolism_Homo sapiens_hsa005650.52774431
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52268149
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51153710
137Lysine degradation_Homo sapiens_hsa003100.49936744
138Collecting duct acid secretion_Homo sapiens_hsa049660.49470900
139Sulfur metabolism_Homo sapiens_hsa009200.47207298
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47064498
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.45546150
142Arginine and proline metabolism_Homo sapiens_hsa003300.45537892
143Regulation of autophagy_Homo sapiens_hsa041400.45249185
144Fatty acid degradation_Homo sapiens_hsa000710.44081065
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41946845
146HIF-1 signaling pathway_Homo sapiens_hsa040660.41587618
147Prolactin signaling pathway_Homo sapiens_hsa049170.41497784
148Cyanoamino acid metabolism_Homo sapiens_hsa004600.41257288
149Colorectal cancer_Homo sapiens_hsa052100.40828026
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40709677
151Melanoma_Homo sapiens_hsa052180.40474227
152Wnt signaling pathway_Homo sapiens_hsa043100.40104498
153Non-small cell lung cancer_Homo sapiens_hsa052230.39870459
154Nicotine addiction_Homo sapiens_hsa050330.39248417
155Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38642983
156Fatty acid biosynthesis_Homo sapiens_hsa000610.38124792
157Focal adhesion_Homo sapiens_hsa045100.37175498
158Prostate cancer_Homo sapiens_hsa052150.36527010
159beta-Alanine metabolism_Homo sapiens_hsa004100.36446464
160Ribosome_Homo sapiens_hsa030100.35948257
1612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35921608
162Renin-angiotensin system_Homo sapiens_hsa046140.35587297
163Axon guidance_Homo sapiens_hsa043600.34935317
164Tight junction_Homo sapiens_hsa045300.34824513
165FoxO signaling pathway_Homo sapiens_hsa040680.34375861
166Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33145816
167Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33057140
168Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33018375
169Retinol metabolism_Homo sapiens_hsa008300.32547890
170Caffeine metabolism_Homo sapiens_hsa002320.32509274
171Adherens junction_Homo sapiens_hsa045200.32424600
172Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30972803
173ECM-receptor interaction_Homo sapiens_hsa045120.30354024
174Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30324712
175Linoleic acid metabolism_Homo sapiens_hsa005910.29523331
176Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29409247
177Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29375358
178Pathways in cancer_Homo sapiens_hsa052000.26245185
179VEGF signaling pathway_Homo sapiens_hsa043700.25368327
180mRNA surveillance pathway_Homo sapiens_hsa030150.21958076

Most similar genes based on co-expression Upload to Enrichr

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