ULBP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.62963057
2Golgi transport vesicle coating (GO:0048200)5.00282042
3COPI coating of Golgi vesicle (GO:0048205)5.00282042
4nuclear pore complex assembly (GO:0051292)4.55305441
5cell adhesion mediated by integrin (GO:0033627)4.53911699
6nuclear pore organization (GO:0006999)4.03417295
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.86506905
8protein retention in ER lumen (GO:0006621)3.83287286
9DNA unwinding involved in DNA replication (GO:0006268)3.80025313
10mitotic metaphase plate congression (GO:0007080)3.75288147
11protein localization to endosome (GO:0036010)3.65565530
12mitotic chromosome condensation (GO:0007076)3.57011861
13pore complex assembly (GO:0046931)3.48016856
14dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.47026509
15protein localization to chromosome, centromeric region (GO:0071459)3.44498513
16desmosome organization (GO:0002934)3.43427177
17skin morphogenesis (GO:0043589)3.43133988
18ribosome assembly (GO:0042255)3.42914128
19protein localization to kinetochore (GO:0034501)3.40628958
20protein maturation by protein folding (GO:0022417)3.37513543
21cell-substrate junction assembly (GO:0007044)3.35611206
22protein complex localization (GO:0031503)3.27244981
23establishment of integrated proviral latency (GO:0075713)3.23915154
24metaphase plate congression (GO:0051310)3.13675748
25cellular protein complex localization (GO:0034629)3.12582207
26regulation of translational fidelity (GO:0006450)3.09384430
27establishment of chromosome localization (GO:0051303)3.06595287
28mitotic sister chromatid segregation (GO:0000070)3.06301715
29mesodermal cell differentiation (GO:0048333)3.04521059
30regulation of translational termination (GO:0006449)3.04405011
31nucleobase-containing small molecule interconversion (GO:0015949)3.04358572
32negative regulation of chondrocyte differentiation (GO:0032331)3.03320098
33positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.00055097
34proline biosynthetic process (GO:0006561)2.97644997
35regulation of transforming growth factor beta2 production (GO:0032909)2.97029613
36regulation of sister chromatid cohesion (GO:0007063)2.96730794
37wound healing, spreading of epidermal cells (GO:0035313)2.93894387
38heterochromatin organization (GO:0070828)2.93825479
39layer formation in cerebral cortex (GO:0021819)2.92310737
40nuclear envelope reassembly (GO:0031468)2.87664885
41mitotic nuclear envelope reassembly (GO:0007084)2.87664885
42substrate-dependent cell migration (GO:0006929)2.87649059
43peptidyl-arginine omega-N-methylation (GO:0035247)2.86056570
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85536207
45sister chromatid segregation (GO:0000819)2.85011495
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.75974486
47* natural killer cell mediated immunity (GO:0002228)2.75787941
48* natural killer cell mediated cytotoxicity (GO:0042267)2.75787941
49ganglion development (GO:0061548)2.73904347
50endodermal cell differentiation (GO:0035987)2.72391580
51mitotic cytokinesis (GO:0000281)2.72116243
52retina vasculature morphogenesis in camera-type eye (GO:0061299)2.69745353
53hippo signaling (GO:0035329)2.65583108
54adherens junction assembly (GO:0034333)2.64210062
55paraxial mesoderm development (GO:0048339)2.64009374
56activation of Rac GTPase activity (GO:0032863)2.62502244
57establishment of viral latency (GO:0019043)2.61378686
58negative regulation of keratinocyte proliferation (GO:0010839)2.61136203
59DNA replication initiation (GO:0006270)2.59822372
60regulation of mitotic spindle organization (GO:0060236)2.57027629
61ventricular cardiac muscle cell development (GO:0055015)2.56503668
62planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56458109
63DNA strand elongation involved in DNA replication (GO:0006271)2.56068266
64barbed-end actin filament capping (GO:0051016)2.55448402
65COPII vesicle coating (GO:0048208)2.55146137
66regulation of spindle organization (GO:0090224)2.53515371
67formation of translation preinitiation complex (GO:0001731)2.53257986
68DNA strand elongation (GO:0022616)2.52698855
69regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52691593
70gap junction assembly (GO:0016264)2.52105356
71protein localization to microtubule (GO:0035372)2.51921373
72nuclear envelope disassembly (GO:0051081)2.51493595
73membrane disassembly (GO:0030397)2.51493595
74mammary gland epithelial cell proliferation (GO:0033598)2.50453074
75muscle cell migration (GO:0014812)2.49076079
76mitotic nuclear envelope disassembly (GO:0007077)2.48953867
77endothelial cell morphogenesis (GO:0001886)2.48927703
78regulation of mammary gland epithelial cell proliferation (GO:0033599)2.48804443
79epithelial cell-cell adhesion (GO:0090136)2.48510474
80wound healing, spreading of cells (GO:0044319)2.46538720
81chromosome condensation (GO:0030261)2.46199153
82morphogenesis of an epithelial sheet (GO:0002011)2.45246693
83regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.41701367
84vesicle coating (GO:0006901)2.40908189
85positive regulation of DNA-dependent DNA replication (GO:2000105)2.40779496
86folic acid-containing compound biosynthetic process (GO:0009396)2.40311312
87L-serine transport (GO:0015825)2.39986204
88double-strand break repair via nonhomologous end joining (GO:0006303)2.37291372
89non-recombinational repair (GO:0000726)2.37291372
90mitotic spindle organization (GO:0007052)2.37133990
91basement membrane organization (GO:0071711)2.35656223
92peptidyl-arginine N-methylation (GO:0035246)2.34612842
93peptidyl-arginine methylation (GO:0018216)2.34612842
94DNA duplex unwinding (GO:0032508)2.34013402
95cell migration involved in sprouting angiogenesis (GO:0002042)2.32982922
96regulation of cardioblast differentiation (GO:0051890)2.32291428
97de novo protein folding (GO:0006458)2.32138355
98cytoskeleton-dependent cytokinesis (GO:0061640)2.32031337
99cellular response to vitamin D (GO:0071305)2.31720049
100spliceosomal tri-snRNP complex assembly (GO:0000244)2.30540233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.49344477
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.66631774
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.76836251
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.14845160
5AR_21909140_ChIP-Seq_LNCAP_Human3.10773818
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.85650631
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84308367
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.76722208
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.74827541
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53068338
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50877159
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42904858
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35615081
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.22716372
15ZNF263_19887448_ChIP-Seq_K562_Human2.21141946
16CLOCK_20551151_ChIP-Seq_293T_Human2.16359900
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15399849
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.08021252
19ZFX_18555785_ChIP-Seq_MESCs_Mouse2.01872159
20MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99756365
21XRN2_22483619_ChIP-Seq_HELA_Human1.96922739
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93801500
23DCP1A_22483619_ChIP-Seq_HELA_Human1.92950673
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92191001
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.89750938
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85700447
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85636502
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.84684315
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83950536
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.79772758
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79385954
32* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.76312105
33* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.76312105
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75496694
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70757259
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65630646
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64326877
38KLF4_18555785_ChIP-Seq_MESCs_Mouse1.64124100
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.61852956
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61213363
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61011130
42ATF3_27146783_Chip-Seq_COLON_Human1.59017335
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58668877
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58511047
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56409578
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54284793
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53995074
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52600540
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51753831
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50913577
51HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.48028219
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47443700
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43698967
54ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.41795307
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39309387
56CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.37678260
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37417559
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36970522
59TTF2_22483619_ChIP-Seq_HELA_Human1.36246351
60* UBF1/2_26484160_Chip-Seq_HMECs_Human1.36067122
61TP53_22127205_ChIP-Seq_IMR90_Human1.34067556
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.33711890
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32827057
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32504227
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31294432
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29281307
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28770424
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27473430
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26236828
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24639180
71TFEB_21752829_ChIP-Seq_HELA_Human1.24086797
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22762065
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22425058
74GABP_19822575_ChIP-Seq_HepG2_Human1.20419958
75TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.19256336
76BRD4_25478319_ChIP-Seq_HGPS_Human1.18799644
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18619477
78SOX17_20123909_ChIP-Seq_XEN_Mouse1.18409027
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18379289
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16713332
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16567520
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.12041856
83ELK1_19687146_ChIP-ChIP_HELA_Human1.11352400
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11208257
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.09389800
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05255014
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05211388
88CHD1_26751641_Chip-Seq_LNCaP_Human1.04382272
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00932300
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00727460
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00016102
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99586659
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99488267
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99303676
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99011034
96RACK7_27058665_Chip-Seq_MCF-7_Human0.97970487
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97489604
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.97156121
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96054076
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94842319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.72967836
2MP0003705_abnormal_hypodermis_morpholog3.66396794
3MP0004272_abnormal_basement_membrane3.50333577
4MP0005623_abnormal_meninges_morphology3.21832073
5MP0010234_abnormal_vibrissa_follicle3.16080824
6MP0003566_abnormal_cell_adhesion3.05978897
7MP0010352_gastrointestinal_tract_polyps2.94201424
8MP0002877_abnormal_melanocyte_morpholog2.68499446
9MP0006054_spinal_hemorrhage2.48150023
10MP0005257_abnormal_intraocular_pressure2.38993641
11MP0009053_abnormal_anal_canal2.24122501
12MP0000537_abnormal_urethra_morphology2.22918868
13MP0010368_abnormal_lymphatic_system2.05072599
14MP0003693_abnormal_embryo_hatching2.02956887
15MP0003111_abnormal_nucleus_morphology2.02790071
16MP0000579_abnormal_nail_morphology2.01640260
17MP0004957_abnormal_blastocyst_morpholog1.95778148
18MP0003941_abnormal_skin_development1.89884061
19MP0010094_abnormal_chromosome_stability1.88823178
20MP0010030_abnormal_orbit_morphology1.88660145
21MP0002060_abnormal_skin_morphology1.87009519
22MP0008932_abnormal_embryonic_tissue1.84018679
23MP0002234_abnormal_pharynx_morphology1.73743523
24MP0003077_abnormal_cell_cycle1.73405832
25MP0000762_abnormal_tongue_morphology1.72575071
26MP0005275_abnormal_skin_tensile1.64131785
27MP0005501_abnormal_skin_physiology1.58603237
28MP0004233_abnormal_muscle_weight1.58220673
29MP0005023_abnormal_wound_healing1.49785009
30MP0000467_abnormal_esophagus_morphology1.49516856
31MP0003950_abnormal_plasma_membrane1.46064595
32MP0003091_abnormal_cell_migration1.46049938
33MP0001849_ear_inflammation1.41505909
34MP0003385_abnormal_body_wall1.38720723
35MP0003315_abnormal_perineum_morphology1.38311813
36MP0002697_abnormal_eye_size1.35727896
37MP0002796_impaired_skin_barrier1.34729934
38MP0000013_abnormal_adipose_tissue1.33685420
39MP0009697_abnormal_copulation1.32106729
40MP0000733_abnormal_muscle_development1.31829664
41MP0000534_abnormal_ureter_morphology1.31536860
42MP0001299_abnormal_eye_distance/1.30758987
43MP0008007_abnormal_cellular_replicative1.30247275
44MP0001730_embryonic_growth_arrest1.27557027
45MP0000350_abnormal_cell_proliferation1.26710517
46MP0001915_intracranial_hemorrhage1.25205882
47MP0003279_aneurysm1.24947031
48MP0010678_abnormal_skin_adnexa1.24614631
49MP0003453_abnormal_keratinocyte_physiol1.18072444
50MP0002098_abnormal_vibrissa_morphology1.15013036
51MP0001216_abnormal_epidermal_layer1.11240708
52MP0002085_abnormal_embryonic_tissue1.10632384
53MP0002896_abnormal_bone_mineralization1.09060611
54MP0002084_abnormal_developmental_patter1.08907700
55MP0004858_abnormal_nervous_system1.08600704
56MP0005451_abnormal_body_composition1.07276180
57MP0001672_abnormal_embryogenesis/_devel1.05966754
58MP0005380_embryogenesis_phenotype1.05966754
59MP0002080_prenatal_lethality1.05557233
60MP0000003_abnormal_adipose_tissue1.05177005
61MP0009250_abnormal_appendicular_skeleto1.03615699
62MP0005197_abnormal_uvea_morphology1.02567284
63MP0002092_abnormal_eye_morphology1.00868361
64MP0005076_abnormal_cell_differentiation0.99926742
65MP0005508_abnormal_skeleton_morphology0.99726298
66MP0010771_integument_phenotype0.98848398
67MP0001243_abnormal_dermal_layer0.98526548
68MP0003984_embryonic_growth_retardation0.98264226
69MP0000767_abnormal_smooth_muscle0.97191629
70MP0009384_cardiac_valve_regurgitation0.96862883
71MP0005621_abnormal_cell_physiology0.96696565
72MP0003942_abnormal_urinary_system0.95672220
73MP0003755_abnormal_palate_morphology0.95669510
74MP0003937_abnormal_limbs/digits/tail_de0.95283155
75MP0002086_abnormal_extraembryonic_tissu0.93943541
76MP0008058_abnormal_DNA_repair0.93349515
77MP0003935_abnormal_craniofacial_develop0.93174302
78MP0004197_abnormal_fetal_growth/weight/0.93067772
79MP0000627_abnormal_mammary_gland0.92918855
80MP0001879_abnormal_lymphatic_vessel0.92326899
81MP0004185_abnormal_adipocyte_glucose0.91578238
82MP0002088_abnormal_embryonic_growth/wei0.91082748
83MP0000428_abnormal_craniofacial_morphol0.89967361
84MP0000358_abnormal_cell_content/0.88412928
85MP0001697_abnormal_embryo_size0.88141782
86MP0002282_abnormal_trachea_morphology0.86745765
87MP0001958_emphysema0.86724635
88MP0002111_abnormal_tail_morphology0.84489575
89MP0000377_abnormal_hair_follicle0.83299124
90MP0005384_cellular_phenotype0.82994111
91MP0002089_abnormal_postnatal_growth/wei0.82788524
92MP0005193_abnormal_anterior_eye0.81570061
93MP0002269_muscular_atrophy0.81471808
94MP0000751_myopathy0.79675397
95MP0000432_abnormal_head_morphology0.78475897
96MP0000749_muscle_degeneration0.78155696
97MP0002114_abnormal_axial_skeleton0.75008803
98MP0001340_abnormal_eyelid_morphology0.74973123
99MP0000516_abnormal_urinary_system0.74266002
100MP0005367_renal/urinary_system_phenotyp0.74266002

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.49816785
2Atrophic scars (HP:0001075)3.88841995
3Protrusio acetabuli (HP:0003179)3.84948989
4Short nail (HP:0001799)3.25756565
5Spinal rigidity (HP:0003306)3.15229290
6Abnormality of dentin (HP:0010299)3.09185285
7Fragile skin (HP:0001030)3.02426390
8Ulnar bowing (HP:0003031)2.94988355
9Abnormality of the umbilical cord (HP:0010881)2.91478555
10Hyperacusis (HP:0010780)2.90663055
11Ankle contracture (HP:0006466)2.86469624
12Follicular hyperkeratosis (HP:0007502)2.80266106
13Insomnia (HP:0100785)2.73209365
14Natal tooth (HP:0000695)2.72622212
15Arterial tortuosity (HP:0005116)2.66670995
16Entropion (HP:0000621)2.60169090
17Upper limb amyotrophy (HP:0009129)2.59873487
18Distal upper limb amyotrophy (HP:0007149)2.59873487
19Vascular tortuosity (HP:0004948)2.58207242
20Abnormality of the distal phalanges of the toes (HP:0010182)2.57468237
21Onycholysis (HP:0001806)2.56094428
22Bladder diverticulum (HP:0000015)2.53910525
23Abnormal umbilical cord blood vessels (HP:0011403)2.51158563
24Single umbilical artery (HP:0001195)2.51158563
25Abnormality of the fetal cardiovascular system (HP:0010948)2.51158563
26Abnormalities of placenta or umbilical cord (HP:0001194)2.48548136
27Pterygium (HP:0001059)2.46607980
28Milia (HP:0001056)2.41351649
29Hand muscle atrophy (HP:0009130)2.39512579
30Aortic dissection (HP:0002647)2.35380752
31Soft skin (HP:0000977)2.34391732
32Fragile nails (HP:0001808)2.33694495
33Distal lower limb amyotrophy (HP:0008944)2.33642470
34Selective tooth agenesis (HP:0001592)2.31240184
35Termporal pattern (HP:0011008)2.31140945
36Insidious onset (HP:0003587)2.31140945
37Vertebral arch anomaly (HP:0008438)2.27289271
38Wormian bones (HP:0002645)2.27150719
39Vertebral compression fractures (HP:0002953)2.26909744
40Achilles tendon contracture (HP:0001771)2.23971836
41Back pain (HP:0003418)2.20915975
42Trismus (HP:0000211)2.16756493
43Elbow flexion contracture (HP:0002987)2.15104323
44Osteolytic defects of the hand bones (HP:0009699)2.14260682
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.14260682
46Short clavicles (HP:0000894)2.12259771
47Tetraparesis (HP:0002273)2.09189727
48Microglossia (HP:0000171)2.09034259
49Deviation of the thumb (HP:0009603)2.07953330
50Broad face (HP:0000283)2.07711317
51Aplasia/Hypoplasia of the clavicles (HP:0006710)2.04558715
52Lower limb amyotrophy (HP:0007210)2.04034887
53Increased connective tissue (HP:0009025)2.03131241
54Syringomyelia (HP:0003396)1.98714635
55Spinal cord lesions (HP:0100561)1.98714635
56Difficulty climbing stairs (HP:0003551)1.96654507
57Generalized amyotrophy (HP:0003700)1.95889637
58Cervical subluxation (HP:0003308)1.94186675
59Advanced eruption of teeth (HP:0006288)1.93069214
60Shallow orbits (HP:0000586)1.91474099
61Genu recurvatum (HP:0002816)1.91281581
62Poikiloderma (HP:0001029)1.91181588
63Proximal placement of thumb (HP:0009623)1.90158689
64High anterior hairline (HP:0009890)1.89089970
65Reduced subcutaneous adipose tissue (HP:0003758)1.88022192
66Shoulder girdle muscle weakness (HP:0003547)1.87214090
67Nail dystrophy (HP:0008404)1.86585352
68Amniotic constriction ring (HP:0009775)1.85960770
69Abnormality of placental membranes (HP:0011409)1.85960770
70Abnormality of the Achilles tendon (HP:0005109)1.84931567
71Abnormality of oral frenula (HP:0000190)1.84804251
72Abnormality of nail color (HP:0100643)1.84313893
73Pili torti (HP:0003777)1.83993661
74Right ventricular cardiomyopathy (HP:0011663)1.80863305
75Abnormality of the hip-girdle musculature (HP:0001445)1.80525618
76Abnormality of the musculature of the pelvis (HP:0001469)1.80525618
77Mildly elevated creatine phosphokinase (HP:0008180)1.79530480
78Plantar hyperkeratosis (HP:0007556)1.77346762
79Abnormality of the phalanges of the hallux (HP:0010057)1.76292118
80Renal duplication (HP:0000075)1.76049403
81Long palpebral fissure (HP:0000637)1.75626225
82Arnold-Chiari malformation (HP:0002308)1.75498420
83Ankyloglossia (HP:0010296)1.74235318
84Limb-girdle muscle weakness (HP:0003325)1.73803641
85Limb-girdle muscle atrophy (HP:0003797)1.73453604
86Elfin facies (HP:0004428)1.73343983
87Aplasia cutis congenita (HP:0001057)1.72988417
88Protruding ear (HP:0000411)1.71823659
89Ridged nail (HP:0001807)1.71563795
90Mitral regurgitation (HP:0001653)1.70825009
91Pelvic girdle muscle weakness (HP:0003749)1.70179928
92Subacute progressive viral hepatitis (HP:0006572)1.69875296
93Bowel diverticulosis (HP:0005222)1.69272760
94Spastic diplegia (HP:0001264)1.68673547
95Thick nail (HP:0001805)1.68507871
96Increased nuchal translucency (HP:0010880)1.67880803
97Patellar dislocation (HP:0002999)1.67500175
98Rough bone trabeculation (HP:0100670)1.67399999
99Bowed forearm bones (HP:0003956)1.67125126
100Bowing of the arm (HP:0006488)1.67125126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R3.80566550
2EPHA23.21755800
3BUB13.04698494
4PBK3.03371457
5MET2.82484547
6LATS22.21502672
7SRPK12.11665104
8PAK42.03345826
9SMG12.00054377
10EIF2AK31.97914546
11SCYL21.95563691
12EPHB21.88779448
13EIF2AK11.85463520
14PDGFRA1.83587677
15LATS11.78152108
16TTK1.77791423
17EEF2K1.77279807
18ARAF1.74916269
19ICK1.74884511
20CDK121.72154436
21NEK11.66632260
22PTK21.64063641
23TESK11.60593570
24ERBB41.59225740
25IRAK31.53326441
26NME21.52850465
27PIM21.51681198
28TRIB31.48929751
29TTN1.47566738
30TSSK61.43491655
31CDC71.38002210
32SIK11.37083006
33LIMK11.34524822
34NTRK11.32045677
35ERBB31.31888985
36MST41.18656129
37CDK71.12031228
38STK101.10379212
39MOS1.09978246
40LMTK21.08141306
41BCR1.07636992
42CDK81.02763206
43PAK21.02105300
44BRSK21.02009516
45STK381.01764848
46TESK20.99147585
47NEK90.97141429
48PLK30.95343556
49CHEK20.90427957
50PLK10.90215708
51AURKA0.89586004
52AURKB0.89343907
53BRSK10.84646151
54MAP3K80.84488084
55BRAF0.82201016
56MELK0.81643902
57WEE10.81068542
58AKT20.79503126
59RPS6KA40.73825315
60RIPK10.71232142
61CSNK1A1L0.70192441
62NEK20.68638152
63TAOK20.68045412
64BRD40.65625738
65MTOR0.64532394
66EIF2AK20.63925158
67KDR0.61704432
68MAP3K90.61162473
69CSNK1G30.60404174
70ABL20.60327992
71STK38L0.59584510
72TRIM280.58689970
73FER0.58409099
74CHEK10.58407467
75MAPKAPK30.56992066
76CLK10.55952326
77ILK0.55400602
78CDK60.54553693
79ROCK20.54147436
80STK40.53520424
81TAF10.53514760
82MYLK0.53462746
83CDK180.52588390
84CDK140.52145210
85CDK150.50054200
86PRKCI0.48490267
87PRKG20.48400823
88CDK11A0.45256971
89CDK90.43207132
90MAP3K100.43065823
91FLT30.43051567
92CSNK1G10.42224321
93PAK60.41000037
94ZAK0.40451137
95ATR0.40101615
96KSR10.38216652
97PDGFRB0.33227903
98RPS6KB20.32871173
99STK30.32421186
100CSNK1G20.31793259

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.68600214
2DNA replication_Homo sapiens_hsa030302.63193270
3ECM-receptor interaction_Homo sapiens_hsa045122.13249226
4Cell cycle_Homo sapiens_hsa041102.12482815
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.05957494
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.00519557
7Adherens junction_Homo sapiens_hsa045201.93847408
8Biosynthesis of amino acids_Homo sapiens_hsa012301.84582574
9Steroid biosynthesis_Homo sapiens_hsa001001.80407725
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78221166
11Bladder cancer_Homo sapiens_hsa052191.77441532
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70588206
13Hippo signaling pathway_Homo sapiens_hsa043901.69125700
14Non-homologous end-joining_Homo sapiens_hsa034501.67507414
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.67366834
16Pentose phosphate pathway_Homo sapiens_hsa000301.67267599
17Central carbon metabolism in cancer_Homo sapiens_hsa052301.63292101
18p53 signaling pathway_Homo sapiens_hsa041151.59726380
19Mismatch repair_Homo sapiens_hsa034301.59199377
20Focal adhesion_Homo sapiens_hsa045101.59026190
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58144325
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.57757517
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55546849
24Small cell lung cancer_Homo sapiens_hsa052221.54609181
25RNA transport_Homo sapiens_hsa030131.52917396
26Thyroid cancer_Homo sapiens_hsa052161.49586930
27Nucleotide excision repair_Homo sapiens_hsa034201.49028859
28Proteoglycans in cancer_Homo sapiens_hsa052051.40295360
29N-Glycan biosynthesis_Homo sapiens_hsa005101.39471852
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36574418
31MicroRNAs in cancer_Homo sapiens_hsa052061.32720625
32Vitamin B6 metabolism_Homo sapiens_hsa007501.31325751
33Spliceosome_Homo sapiens_hsa030401.22015569
34Pyrimidine metabolism_Homo sapiens_hsa002401.18525631
35Chronic myeloid leukemia_Homo sapiens_hsa052201.18178576
36Carbon metabolism_Homo sapiens_hsa012001.16962278
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14800832
38Basal cell carcinoma_Homo sapiens_hsa052171.10630394
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.08981334
40Melanoma_Homo sapiens_hsa052181.08381184
41Base excision repair_Homo sapiens_hsa034101.07469584
42Proteasome_Homo sapiens_hsa030501.03099788
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01568600
44TGF-beta signaling pathway_Homo sapiens_hsa043501.01281383
45Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99883677
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99194767
47Vibrio cholerae infection_Homo sapiens_hsa051100.97309803
48Colorectal cancer_Homo sapiens_hsa052100.94908734
49Pancreatic cancer_Homo sapiens_hsa052120.94055370
50Shigellosis_Homo sapiens_hsa051310.93794463
51Endometrial cancer_Homo sapiens_hsa052130.92576075
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91651832
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90528707
54Galactose metabolism_Homo sapiens_hsa000520.90214785
55Alcoholism_Homo sapiens_hsa050340.88220950
56Viral carcinogenesis_Homo sapiens_hsa052030.87684611
57Axon guidance_Homo sapiens_hsa043600.87025683
58mRNA surveillance pathway_Homo sapiens_hsa030150.86729387
59Pyruvate metabolism_Homo sapiens_hsa006200.86078723
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84792549
61One carbon pool by folate_Homo sapiens_hsa006700.83529685
62Pathways in cancer_Homo sapiens_hsa052000.83254752
63Tight junction_Homo sapiens_hsa045300.82540108
64Hedgehog signaling pathway_Homo sapiens_hsa043400.80676580
65PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80459357
66Apoptosis_Homo sapiens_hsa042100.77744357
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77563617
68Folate biosynthesis_Homo sapiens_hsa007900.73978648
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73514841
70Wnt signaling pathway_Homo sapiens_hsa043100.72318573
71Dilated cardiomyopathy_Homo sapiens_hsa054140.71579653
72Fatty acid elongation_Homo sapiens_hsa000620.71349787
73Basal transcription factors_Homo sapiens_hsa030220.71276017
74Oocyte meiosis_Homo sapiens_hsa041140.68509965
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66159997
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64528017
77Prostate cancer_Homo sapiens_hsa052150.63567603
78Glioma_Homo sapiens_hsa052140.61798321
79Arginine and proline metabolism_Homo sapiens_hsa003300.61327699
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60940789
81Amoebiasis_Homo sapiens_hsa051460.59941299
82Fatty acid biosynthesis_Homo sapiens_hsa000610.59622307
83Sulfur relay system_Homo sapiens_hsa041220.59166377
84Lysine degradation_Homo sapiens_hsa003100.58538955
85ErbB signaling pathway_Homo sapiens_hsa040120.57379775
86Fanconi anemia pathway_Homo sapiens_hsa034600.56367065
87Prion diseases_Homo sapiens_hsa050200.54997443
88Fructose and mannose metabolism_Homo sapiens_hsa000510.53816182
89Notch signaling pathway_Homo sapiens_hsa043300.53701620
90Gap junction_Homo sapiens_hsa045400.52466276
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52390071
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52025223
93Non-small cell lung cancer_Homo sapiens_hsa052230.48421019
94RNA polymerase_Homo sapiens_hsa030200.47973790
95Salmonella infection_Homo sapiens_hsa051320.46472333
96Arginine biosynthesis_Homo sapiens_hsa002200.45039015
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43745590
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43681353
99AMPK signaling pathway_Homo sapiens_hsa041520.42985097
100Sphingolipid metabolism_Homo sapiens_hsa006000.42471477

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