ULK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.28820235
2behavioral response to nicotine (GO:0035095)4.17980333
3nucleobase catabolic process (GO:0046113)3.73730785
4central nervous system myelination (GO:0022010)3.60147344
5axon ensheathment in central nervous system (GO:0032291)3.60147344
6synaptic vesicle maturation (GO:0016188)3.48373762
7vocalization behavior (GO:0071625)3.35715301
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.34096937
9layer formation in cerebral cortex (GO:0021819)3.32737427
10locomotory exploration behavior (GO:0035641)3.31815840
11G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.31026549
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.29043301
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.25766659
14dendrite morphogenesis (GO:0048813)3.22401809
15regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.21180992
16neurotransmitter-gated ion channel clustering (GO:0072578)3.20067051
17neuronal ion channel clustering (GO:0045161)3.18215578
18piRNA metabolic process (GO:0034587)3.14441176
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.13041497
20regulation of synapse structural plasticity (GO:0051823)3.11239254
21neuron cell-cell adhesion (GO:0007158)3.08784111
22gamma-aminobutyric acid transport (GO:0015812)3.07463286
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07148571
24regulation of glutamate receptor signaling pathway (GO:1900449)3.02365281
25dendritic spine morphogenesis (GO:0060997)3.01488125
26glutamate secretion (GO:0014047)2.97952571
27synaptic vesicle exocytosis (GO:0016079)2.92475402
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88129521
29protein localization to synapse (GO:0035418)2.87557557
30regulation of synaptic vesicle exocytosis (GO:2000300)2.85594562
31neuron recognition (GO:0008038)2.83570225
32neuromuscular synaptic transmission (GO:0007274)2.82435228
33startle response (GO:0001964)2.80855838
34positive regulation of synapse assembly (GO:0051965)2.79443312
35adult walking behavior (GO:0007628)2.79200472
36short-term memory (GO:0007614)2.78904445
37multicellular organismal signaling (GO:0035637)2.78643892
38central nervous system neuron axonogenesis (GO:0021955)2.77849265
39exploration behavior (GO:0035640)2.77522445
40synaptic vesicle docking involved in exocytosis (GO:0016081)2.77477690
41cellular ketone body metabolic process (GO:0046950)2.77364777
42regulation of membrane repolarization (GO:0060306)2.75941190
43alpha-linolenic acid metabolic process (GO:0036109)2.75872797
44axonal fasciculation (GO:0007413)2.72335287
45neuron maturation (GO:0042551)2.68597769
46response to pheromone (GO:0019236)2.68396094
47negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68167458
48positive regulation of meiosis (GO:0045836)2.67450673
49L-phenylalanine catabolic process (GO:0006559)2.67014122
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.67014122
51neuronal action potential (GO:0019228)2.66597461
52mechanosensory behavior (GO:0007638)2.65064023
53regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61678507
54regulation of synaptic vesicle transport (GO:1902803)2.61210768
55regulation of neuronal synaptic plasticity (GO:0048168)2.60633099
56nonmotile primary cilium assembly (GO:0035058)2.59112350
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.57080500
58ionotropic glutamate receptor signaling pathway (GO:0035235)2.56387726
59neurotransmitter secretion (GO:0007269)2.56276366
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53809915
61positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.53728256
62proline transport (GO:0015824)2.52977239
63adult behavior (GO:0030534)2.51682700
64behavioral response to ethanol (GO:0048149)2.49996927
65cerebellar Purkinje cell differentiation (GO:0021702)2.49860455
66DNA methylation involved in gamete generation (GO:0043046)2.49442096
67neurofilament cytoskeleton organization (GO:0060052)2.48108074
68regulation of dendritic spine morphogenesis (GO:0061001)2.47151996
69regulation of neurotransmitter secretion (GO:0046928)2.45147356
70positive regulation of meiotic cell cycle (GO:0051446)2.44609360
71activation of protein kinase A activity (GO:0034199)2.44587784
72cochlea development (GO:0090102)2.43971299
73regulation of synapse assembly (GO:0051963)2.43640651
74regulation of respiratory system process (GO:0044065)2.43472645
75retinal cone cell development (GO:0046549)2.43107886
76serotonin metabolic process (GO:0042428)2.42902742
77regulation of calcium ion-dependent exocytosis (GO:0017158)2.42629065
78positive regulation of action potential (GO:0045760)2.42358422
79positive regulation of dendritic spine development (GO:0060999)2.41528554
80action potential (GO:0001508)2.41253105
81synaptic transmission (GO:0007268)2.40896683
82behavioral defense response (GO:0002209)2.39038060
83behavioral fear response (GO:0001662)2.39038060
84positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.38978907
85central nervous system projection neuron axonogenesis (GO:0021952)2.38840175
86long-term memory (GO:0007616)2.38273220
87ketone body metabolic process (GO:1902224)2.37626946
88neuronal action potential propagation (GO:0019227)2.36863560
89presynaptic membrane assembly (GO:0097105)2.34708006
90L-phenylalanine metabolic process (GO:0006558)2.33114984
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.33114984
92nerve growth factor signaling pathway (GO:0038180)2.31693027
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.27689814
94regulation of dendritic spine development (GO:0060998)2.27484359
95glutamate receptor signaling pathway (GO:0007215)2.26536732
96establishment of mitochondrion localization (GO:0051654)2.26507225
97synaptic transmission, glutamatergic (GO:0035249)2.25993337
98cerebral cortex radially oriented cell migration (GO:0021799)2.25814429
99regulation of excitatory postsynaptic membrane potential (GO:0060079)2.25515718
100cell migration in hindbrain (GO:0021535)2.23744595
101auditory behavior (GO:0031223)2.22983794
102aromatic amino acid family catabolic process (GO:0009074)2.22820637
103regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.21881593
104bile acid biosynthetic process (GO:0006699)2.20181484
105membrane depolarization during action potential (GO:0086010)2.19430510
106neuron-neuron synaptic transmission (GO:0007270)2.18756171
107negative regulation of synaptic transmission, GABAergic (GO:0032229)2.18392176
108regulation of synaptic transmission, glutamatergic (GO:0051966)2.17482195
109presynaptic membrane organization (GO:0097090)2.17323783
110clathrin coat assembly (GO:0048268)2.17245010
111fatty acid transmembrane transport (GO:1902001)2.16791686
112response to auditory stimulus (GO:0010996)2.16558287
113establishment of nucleus localization (GO:0040023)2.16411148
114regulation of postsynaptic membrane potential (GO:0060078)2.15457437
115cerebellar granule cell differentiation (GO:0021707)2.15186398
116fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.13275938
117dicarboxylic acid biosynthetic process (GO:0043650)2.12971071
118carnitine shuttle (GO:0006853)2.12600637
119positive regulation of synapse maturation (GO:0090129)2.12004712
120* axon extension (GO:0048675)2.11698932
121complement activation, alternative pathway (GO:0006957)2.11013957
122alanine transport (GO:0032328)2.08672094
123transmission of nerve impulse (GO:0019226)2.08571852
124organelle transport along microtubule (GO:0072384)2.08419862
125regulation of ARF protein signal transduction (GO:0032012)2.08204884
126regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.07013689
127neuromuscular process controlling balance (GO:0050885)2.05813977
128establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.04186317
129mitochondrion transport along microtubule (GO:0047497)2.04186317
130calcium ion-dependent exocytosis (GO:0017156)2.04066545
131neurotransmitter transport (GO:0006836)2.03919475
132regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.03884132
133postsynaptic membrane organization (GO:0001941)2.03601338
134triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.03287649
135negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.02956645
136regulation of female receptivity (GO:0045924)2.02772432
137synapse assembly (GO:0007416)2.02706223
138response to methylmercury (GO:0051597)2.02647470
139positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.02413050
140synapse organization (GO:0050808)2.02354839
141membrane depolarization (GO:0051899)2.01847650
142glutamate metabolic process (GO:0006536)1.98901119
143regulation of synaptic plasticity (GO:0048167)1.98852130
144L-amino acid import (GO:0043092)1.98078672

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.81017514
2GBX2_23144817_ChIP-Seq_PC3_Human2.88093877
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25607517
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23645868
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09029055
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05134254
7DROSHA_22980978_ChIP-Seq_HELA_Human2.01725597
8RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98903984
9EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98903984
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95553901
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93096120
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92628046
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87980626
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86737827
15AR_21572438_ChIP-Seq_LNCaP_Human1.83130965
16EZH2_27304074_Chip-Seq_ESCs_Mouse1.80749364
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76653659
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74260716
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.72996191
20REST_21632747_ChIP-Seq_MESCs_Mouse1.69772863
21RNF2_27304074_Chip-Seq_NSC_Mouse1.68066420
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66362781
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65722921
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.65129378
25VDR_22108803_ChIP-Seq_LS180_Human1.64916513
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61293313
27IGF1R_20145208_ChIP-Seq_DFB_Human1.60053220
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.57844885
29TAF15_26573619_Chip-Seq_HEK293_Human1.57428204
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48259507
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46740843
32* RARB_27405468_Chip-Seq_BRAIN_Mouse1.45752996
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.42283731
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41215554
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40400015
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39871897
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37938743
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37482859
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37423049
40FUS_26573619_Chip-Seq_HEK293_Human1.36951390
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36723021
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35801871
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34227464
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33405313
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.33219734
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.32702158
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32326792
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30059754
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.28478126
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27812408
51P300_19829295_ChIP-Seq_ESCs_Human1.27665023
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27576251
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27145475
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.26193657
55* RXR_22158963_ChIP-Seq_LIVER_Mouse1.26164801
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.25905444
57ZNF274_21170338_ChIP-Seq_K562_Hela1.25035278
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24683471
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24222547
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.24157991
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.22110982
62AHR_22903824_ChIP-Seq_MCF-7_Human1.18498423
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17910766
64* STAT3_23295773_ChIP-Seq_U87_Human1.16316682
65AR_25329375_ChIP-Seq_VCAP_Human1.15684726
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15357656
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14332475
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.14228619
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14226387
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13563162
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12794136
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12531661
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.10900545
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10892385
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10763114
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.10098542
77LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08673634
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08151513
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08005719
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07544110
81BCAT_22108803_ChIP-Seq_LS180_Human1.04906672
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.04099774
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03073620
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03073620
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02740014
86TCF4_23295773_ChIP-Seq_U87_Human1.02449598
87AR_19668381_ChIP-Seq_PC3_Human1.01838933
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01711723
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.01579494
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00857284
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00837629
92TP53_16413492_ChIP-PET_HCT116_Human1.00636162
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.99769081
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99689949
95RING1B_27294783_Chip-Seq_NPCs_Mouse0.99118035
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99040646
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98415626
98ER_23166858_ChIP-Seq_MCF-7_Human0.98232813
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.97878312
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97793562
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97595838
102TP53_18474530_ChIP-ChIP_U2OS_Human0.97290569
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97219837
104* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96860614
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96608778
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96011025
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95551387
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95359070
109P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95221156
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94943726
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94943726
112FLI1_21867929_ChIP-Seq_TH2_Mouse0.94781391
113RING1B_27294783_Chip-Seq_ESCs_Mouse0.94420378
114FOXA2_19822575_ChIP-Seq_HepG2_Human0.91169158
115RUNX2_22187159_ChIP-Seq_PCA_Human0.90763453
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90279483
117SMAD4_21741376_ChIP-Seq_EPCs_Human0.90206936
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89610037
119CBP_20019798_ChIP-Seq_JUKART_Human0.89277815
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89277815
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.89171492
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89162725
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87233064
124PRDM14_20953172_ChIP-Seq_ESCs_Human0.86694698

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.39187827
2MP0004270_analgesia3.30787240
3MP0002139_abnormal_hepatobiliary_system2.90556505
4MP0003635_abnormal_synaptic_transmissio2.90272365
5MP0003880_abnormal_central_pattern2.73987385
6MP0002063_abnormal_learning/memory/cond2.45116424
7MP0005360_urolithiasis2.35521291
8MP0005423_abnormal_somatic_nervous2.31142972
9MP0005085_abnormal_gallbladder_physiolo2.28593190
10MP0009745_abnormal_behavioral_response2.27156938
11MP0002064_seizures2.18514580
12MP0002822_catalepsy2.16952259
13MP0009780_abnormal_chondrocyte_physiolo2.15085280
14MP0001486_abnormal_startle_reflex2.08488855
15MP0002837_dystrophic_cardiac_calcinosis2.07373741
16MP0004130_abnormal_muscle_cell2.06515606
17MP0005365_abnormal_bile_salt2.02054871
18MP0002734_abnormal_mechanical_nocicepti1.95186380
19MP0001968_abnormal_touch/_nociception1.94020109
20MP0003329_amyloid_beta_deposits1.93003021
21MP0000778_abnormal_nervous_system1.92984523
22* MP0002572_abnormal_emotion/affect_behav1.92847501
23MP0009046_muscle_twitch1.86964189
24MP0000751_myopathy1.86931810
25MP0003690_abnormal_glial_cell1.80519191
26MP0008877_abnormal_DNA_methylation1.79830889
27MP0002102_abnormal_ear_morphology1.77003320
28MP0002735_abnormal_chemical_nociception1.73189752
29MP0002272_abnormal_nervous_system1.71527033
30MP0004885_abnormal_endolymph1.69173305
31MP0008875_abnormal_xenobiotic_pharmacok1.60846218
32MP0003787_abnormal_imprinting1.59295615
33MP0000920_abnormal_myelination1.58808019
34MP0001440_abnormal_grooming_behavior1.57421138
35MP0004924_abnormal_behavior1.54179507
36MP0005386_behavior/neurological_phenoty1.54179507
37MP0005410_abnormal_fertilization1.50572973
38MP0003633_abnormal_nervous_system1.46697590
39MP0010329_abnormal_lipoprotein_level1.44855368
40MP0002653_abnormal_ependyma_morphology1.44410613
41MP0002067_abnormal_sensory_capabilities1.42756663
42MP0004145_abnormal_muscle_electrophysio1.41087262
43MP0000566_synostosis1.40694364
44MP0003252_abnormal_bile_duct1.40567294
45MP0002638_abnormal_pupillary_reflex1.39763177
46MP0002909_abnormal_adrenal_gland1.38975825
47MP0000569_abnormal_digit_pigmentation1.38963072
48MP0003136_yellow_coat_color1.35924539
49MP0002733_abnormal_thermal_nociception1.35219918
50MP0008569_lethality_at_weaning1.34871737
51MP0002736_abnormal_nociception_after1.34805747
52MP0000604_amyloidosis1.29913599
53MP0004811_abnormal_neuron_physiology1.27621398
54MP0006276_abnormal_autonomic_nervous1.26233138
55MP0002557_abnormal_social/conspecific_i1.26019944
56MP0004858_abnormal_nervous_system1.24881808
57MP0001970_abnormal_pain_threshold1.24537291
58MP0000955_abnormal_spinal_cord1.24314292
59MP0001501_abnormal_sleep_pattern1.22941358
60MP0002184_abnormal_innervation1.22372818
61MP0004133_heterotaxia1.22160285
62MP0001984_abnormal_olfaction1.20618430
63MP0000631_abnormal_neuroendocrine_gland1.19290927
64MP0002752_abnormal_somatic_nervous1.18187931
65MP0003631_nervous_system_phenotype1.17508663
66MP0003283_abnormal_digestive_organ1.14843854
67MP0003122_maternal_imprinting1.14300420
68MP0000026_abnormal_inner_ear1.13222484
69* MP0005535_abnormal_body_temperature1.11743294
70MP0002118_abnormal_lipid_homeostasis1.11542444
71MP0001299_abnormal_eye_distance/1.11315834
72MP0002066_abnormal_motor_capabilities/c1.11124435
73MP0001485_abnormal_pinna_reflex1.09501032
74MP0001986_abnormal_taste_sensitivity1.08381629
75MP0004085_abnormal_heartbeat1.06330134
76MP0003634_abnormal_glial_cell1.05061952
77MP0001529_abnormal_vocalization1.04257732
78MP0002882_abnormal_neuron_morphology1.03890050
79MP0001963_abnormal_hearing_physiology1.03434496
80MP0003879_abnormal_hair_cell1.02687389
81MP0004036_abnormal_muscle_relaxation1.01023879
82MP0004215_abnormal_myocardial_fiber1.00566982
83MP0001188_hyperpigmentation0.99322931
84MP0000747_muscle_weakness0.98047399
85MP0005620_abnormal_muscle_contractility0.97599984
86MP0010030_abnormal_orbit_morphology0.97551449
87MP0003191_abnormal_cellular_cholesterol0.94932092
88MP0005646_abnormal_pituitary_gland0.93011102
89MP0000013_abnormal_adipose_tissue0.92611219
90MP0001177_atelectasis0.92314681
91MP0006292_abnormal_olfactory_placode0.91730729
92MP0003890_abnormal_embryonic-extraembry0.90984496
93MP0002090_abnormal_vision0.90479752
94MP0004484_altered_response_of0.90440247
95MP0002229_neurodegeneration0.90422577
96MP0000749_muscle_degeneration0.89527384
97MP0008874_decreased_physiological_sensi0.89512384
98MP0003646_muscle_fatigue0.88721638
99MP0000049_abnormal_middle_ear0.86704308
100MP0004742_abnormal_vestibular_system0.86616541
101MP0010368_abnormal_lymphatic_system0.86501128
102MP0003075_altered_response_to0.85654869
103MP0001905_abnormal_dopamine_level0.85187467
104MP0005187_abnormal_penis_morphology0.84537432
105MP0003632_abnormal_nervous_system0.84526338
106MP0005174_abnormal_tail_pigmentation0.83985556
107MP0003861_abnormal_nervous_system0.83976177
108MP0003137_abnormal_impulse_conducting0.83889126
109MP0005332_abnormal_amino_acid0.83052312
110MP0005584_abnormal_enzyme/coenzyme_acti0.82445209
111MP0003698_abnormal_male_reproductive0.82115356
112MP0003868_abnormal_feces_composition0.81642482
113MP0003121_genomic_imprinting0.81173719
114MP0002152_abnormal_brain_morphology0.80853945
115MP0005645_abnormal_hypothalamus_physiol0.79334765
116MP0005195_abnormal_posterior_eye0.79075642
117MP0004142_abnormal_muscle_tone0.76640892
118MP0005253_abnormal_eye_physiology0.75698691
119MP0005409_darkened_coat_color0.75138830
120MP0002160_abnormal_reproductive_system0.74454908
121MP0004087_abnormal_muscle_fiber0.73742098
122MP0002069_abnormal_eating/drinking_beha0.73253504
123MP0005503_abnormal_tendon_morphology0.72679989
124MP0003938_abnormal_ear_development0.72658156
125MP0010386_abnormal_urinary_bladder0.72020752
126MP0003195_calcinosis0.70875636
127MP0005248_abnormal_Harderian_gland0.70597123
128MP0000015_abnormal_ear_pigmentation0.68915196
129MP0002972_abnormal_cardiac_muscle0.68905240
130MP0005499_abnormal_olfactory_system0.68637991
131MP0005394_taste/olfaction_phenotype0.68637991
132MP0005670_abnormal_white_adipose0.67982589
133MP0002938_white_spotting0.67110809
134MP0005623_abnormal_meninges_morphology0.66520843
135MP0003119_abnormal_digestive_system0.65868893
136MP0001502_abnormal_circadian_rhythm0.65761525
137MP0005083_abnormal_biliary_tract0.63833903
138MP0005666_abnormal_adipose_tissue0.63790660
139MP0002078_abnormal_glucose_homeostasis0.63262159
140MP0005551_abnormal_eye_electrophysiolog0.63072605

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.96816393
2Neurofibrillary tangles (HP:0002185)3.82383140
3Hyperventilation (HP:0002883)3.76234861
4Myokymia (HP:0002411)3.69965709
5Cerebral inclusion bodies (HP:0100314)3.43200403
6Abnormality of the corticospinal tract (HP:0002492)3.24126510
7Complement deficiency (HP:0004431)3.22161812
8Focal seizures (HP:0007359)3.21494089
9Nephronophthisis (HP:0000090)3.17787611
10Supranuclear gaze palsy (HP:0000605)3.17318718
11Deep venous thrombosis (HP:0002625)3.15870570
12Molar tooth sign on MRI (HP:0002419)3.09654095
13Abnormality of midbrain morphology (HP:0002418)3.09654095
14Exercise-induced myalgia (HP:0003738)3.08089168
15Termporal pattern (HP:0011008)3.05064883
16Insidious onset (HP:0003587)3.05064883
17Gait imbalance (HP:0002141)3.03336990
18Action tremor (HP:0002345)2.90001289
19Visual hallucinations (HP:0002367)2.84570316
20Pancreatic fibrosis (HP:0100732)2.81215617
21Degeneration of the lateral corticospinal tracts (HP:0002314)2.75616885
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.75616885
23Ankle clonus (HP:0011448)2.73538464
24Medial flaring of the eyebrow (HP:0010747)2.72295194
25Genetic anticipation (HP:0003743)2.72042184
26Poor eye contact (HP:0000817)2.68500058
27Abnormality of the renal medulla (HP:0100957)2.68271803
28Impaired vibration sensation in the lower limbs (HP:0002166)2.65988896
29Mutism (HP:0002300)2.65391863
30Broad-based gait (HP:0002136)2.63805654
31Epileptic encephalopathy (HP:0200134)2.62867370
32True hermaphroditism (HP:0010459)2.59078407
33Urinary urgency (HP:0000012)2.58826046
34Abnormal social behavior (HP:0012433)2.58101919
35Impaired social interactions (HP:0000735)2.58101919
36Intention tremor (HP:0002080)2.56468128
37Epidermoid cyst (HP:0200040)2.55421356
38Type II lissencephaly (HP:0007260)2.52401042
39Generalized tonic-clonic seizures (HP:0002069)2.50933820
40Excessive salivation (HP:0003781)2.50643368
41Drooling (HP:0002307)2.50643368
42Abnormal respiratory motile cilium morphology (HP:0005938)2.48261523
43Abnormal respiratory epithelium morphology (HP:0012253)2.48261523
44Torticollis (HP:0000473)2.47882195
45Urinary bladder sphincter dysfunction (HP:0002839)2.47601708
46Pancreatic cysts (HP:0001737)2.45943201
47Chronic hepatic failure (HP:0100626)2.43813824
48Abnormal ciliary motility (HP:0012262)2.42924735
49Congenital primary aphakia (HP:0007707)2.40031968
50Spastic gait (HP:0002064)2.37950342
51Hyperlipoproteinemia (HP:0010980)2.35309627
52Fetal akinesia sequence (HP:0001989)2.34877635
53Postural instability (HP:0002172)2.34099198
54Progressive cerebellar ataxia (HP:0002073)2.32856191
55Abnormality of the lower motor neuron (HP:0002366)2.32796391
56Intrahepatic cholestasis (HP:0001406)2.32571401
57Atonic seizures (HP:0010819)2.32344140
58Lower limb muscle weakness (HP:0007340)2.27358648
59Dysdiadochokinesis (HP:0002075)2.26976264
60Nephrogenic diabetes insipidus (HP:0009806)2.26337940
61Prolonged QT interval (HP:0001657)2.22678485
62Xanthomatosis (HP:0000991)2.21536217
63Dysmetria (HP:0001310)2.20933827
64Inability to walk (HP:0002540)2.20805082
65Abnormality of aromatic amino acid family metabolism (HP:0004338)2.20081842
66Difficulty running (HP:0009046)2.20076600
67Hyporeflexia of lower limbs (HP:0002600)2.19911899
68Ketosis (HP:0001946)2.18862669
69Prolonged partial thromboplastin time (HP:0003645)2.18561043
70Genital tract atresia (HP:0001827)2.17332413
71Anxiety (HP:0000739)2.13579128
72Hemiparesis (HP:0001269)2.13375721
73Scanning speech (HP:0002168)2.12786339
74Pheochromocytoma (HP:0002666)2.12677253
75Depression (HP:0000716)2.12548339
76Absence seizures (HP:0002121)2.12453426
77Vaginal atresia (HP:0000148)2.12085995
78Protruding tongue (HP:0010808)2.10660882
79Amyotrophic lateral sclerosis (HP:0007354)2.10482331
80Blue irides (HP:0000635)2.09997696
81Focal dystonia (HP:0004373)2.09663017
82Papilledema (HP:0001085)2.08694322
83Poor coordination (HP:0002370)2.06611888
84Oligodactyly (hands) (HP:0001180)2.06258086
85Absent/shortened dynein arms (HP:0200106)2.04903992
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.04903992
87Anterior segment dysgenesis (HP:0007700)2.04853546
88Abnormal respiratory motile cilium physiology (HP:0012261)2.04512968
89Sudden death (HP:0001699)2.03516660
90Ketoacidosis (HP:0001993)2.03222915
91Lissencephaly (HP:0001339)2.03172811
92Retinal dysplasia (HP:0007973)2.02545151
93Craniofacial dystonia (HP:0012179)2.02401393
94Inappropriate behavior (HP:0000719)2.02222143
95Congenital stationary night blindness (HP:0007642)2.01134416
96Abnormal eating behavior (HP:0100738)2.00830247
97Muscle hypertrophy of the lower extremities (HP:0008968)2.00741210
98Abnormal EKG (HP:0003115)1.97013965
99Febrile seizures (HP:0002373)1.96465168
100Systemic lupus erythematosus (HP:0002725)1.96123295
101Aplasia/Hypoplasia of the tibia (HP:0005772)1.95969918
102Impaired vibratory sensation (HP:0002495)1.95470737
103Dialeptic seizures (HP:0011146)1.94811058
104Pachygyria (HP:0001302)1.94509860
105Sleep apnea (HP:0010535)1.94134611
106Akinesia (HP:0002304)1.93010148
107Specific learning disability (HP:0001328)1.92183834
108Megalencephaly (HP:0001355)1.92050912
109Calf muscle hypertrophy (HP:0008981)1.91476030
110Truncal ataxia (HP:0002078)1.90530128
111Progressive inability to walk (HP:0002505)1.90347140
112Morphological abnormality of the pyramidal tract (HP:0002062)1.89550183
113Spastic tetraplegia (HP:0002510)1.89302953
114Abnormality of complement system (HP:0005339)1.88471106
115Abnormality of binocular vision (HP:0011514)1.87356197
116Diplopia (HP:0000651)1.87356197
117Amblyopia (HP:0000646)1.87027234
118Hemiplegia (HP:0002301)1.86927960
119Polyphagia (HP:0002591)1.86129222
120Cystic liver disease (HP:0006706)1.84389519
121Gaze-evoked nystagmus (HP:0000640)1.84093186
122Increased corneal curvature (HP:0100692)1.83769120
123Keratoconus (HP:0000563)1.83769120
124Epileptiform EEG discharges (HP:0011182)1.82672107
125Cerebral hemorrhage (HP:0001342)1.82263032
126EEG with generalized epileptiform discharges (HP:0011198)1.81987674
127Agitation (HP:0000713)1.80538181
128Hypoalphalipoproteinemia (HP:0003233)1.80516895
129Hypsarrhythmia (HP:0002521)1.80041269
130Abnormal drinking behavior (HP:0030082)1.79848280
131Polydipsia (HP:0001959)1.79848280
132Shawl scrotum (HP:0000049)1.79701561
133Neuronal loss in central nervous system (HP:0002529)1.79310057
134Decreased central vision (HP:0007663)1.78927616
135Aplasia/Hypoplasia of the lens (HP:0008063)1.78917826
136Limb dystonia (HP:0002451)1.78354244
137Anencephaly (HP:0002323)1.77799328
138Spastic tetraparesis (HP:0001285)1.77065063
139Macroorchidism (HP:0000053)1.76531357
140Exotropia (HP:0000577)1.75480457
141Syncope (HP:0001279)1.74977612
142Postaxial hand polydactyly (HP:0001162)1.73996800
143Fair hair (HP:0002286)1.73918325
144Neuroendocrine neoplasm (HP:0100634)1.71592312
145Short tibia (HP:0005736)1.70780644
146Onion bulb formation (HP:0003383)1.69684314
147Generalized myoclonic seizures (HP:0002123)1.69580853
148Absent speech (HP:0001344)1.68688570
149Status epilepticus (HP:0002133)1.68594898
150Increased variability in muscle fiber diameter (HP:0003557)1.68516693
151Widely spaced teeth (HP:0000687)1.68117216
152Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.68095390
153Neoplasm of the adrenal cortex (HP:0100641)1.67023027
154Obstructive sleep apnea (HP:0002870)1.66833011
155Abnormality of the calf musculature (HP:0001430)1.64598089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.52514178
2EPHA42.79092578
3MAP3K42.28456705
4NTRK32.26644186
5PHKG22.20014656
6PHKG12.20014656
7DAPK22.01222466
8MAP3K91.93051273
9PRKD31.89568903
10MINK11.85175178
11MAP2K41.82139466
12PAK61.79146066
13MAP2K71.76526163
14CASK1.63789061
15MAPK131.61883055
16NTRK21.58683765
17NTRK11.50170203
18PDK31.42321642
19PDK41.42321642
20PKN11.37371075
21PDK21.35188895
22CDK191.34970091
23CAMK1G1.34364330
24FGFR21.31875614
25CAMKK11.31252057
26ADRBK21.29739574
27TNIK1.27222261
28WNK31.26025203
29SIK21.25963268
30CDK51.23962903
31KSR21.22159487
32STK391.17249977
33PINK11.12823614
34SGK2231.12471778
35SGK4941.12471778
36MAPK151.12467882
37BMPR1B1.12261683
38ERBB31.11272070
39MAPK121.11013724
40INSRR1.10946021
41KSR11.07080584
42RET1.06565367
43TYRO31.04050560
44PRKCH1.03557024
45PTK2B1.03494755
46CSNK1G21.03288913
47PAK31.02588025
48PLK20.99069979
49CAMK40.96478363
50SGK30.92802191
51SGK20.92069199
52GRK50.91274691
53EPHB20.90769273
54STK110.90656082
55OXSR10.87313436
56SIK10.86983456
57MARK20.86859049
58PRPF4B0.86575686
59RIPK10.86054167
60TGFBR20.85105890
61ICK0.84401334
62GRK10.83330396
63CAMK2A0.83273112
64DMPK0.82106621
65PDK10.79973777
66PRKCG0.79353559
67ACVR1B0.79146840
68BCR0.79113774
69STK380.78283807
70MAP3K20.77739526
71WNK10.77357374
72TRIB30.76420968
73UHMK10.75199405
74LMTK20.72001189
75PDPK10.71943483
76DYRK20.71800615
77OBSCN0.70455074
78PRKCZ0.70200167
79CAMK1D0.70170283
80TTN0.68868181
81CSNK1A1L0.68562916
82LATS20.67876515
83TAOK30.67769458
84RPS6KA20.64723527
85MAP3K70.63867910
86TNK20.63306883
87SGK10.63306047
88WNK40.61894064
89PRKCE0.60834987
90ADRBK10.59833760
91RIPK40.58184998
92CSNK1G30.57772713
93FES0.57694189
94EPHB10.57667794
95PKN20.57579618
96CAMK2B0.57251848
97GRK70.55994986
98MAP4K20.54822724
99PRKAA10.51826900
100PRKACA0.51737328
101ROCK10.51302900
102DYRK1A0.51006680
103FYN0.50854213
104PIK3CA0.49801761
105PNCK0.49534654
106CAMK10.48985053
107PRKG10.48888673
108MAP3K60.48665851
109CAMKK20.48110912
110NEK60.47369064
111PRKD10.47063615
112CDK30.46861912
113EPHA30.46791058
114PDGFRA0.45690089
115FRK0.43856615
116CSNK1G10.43377459
117DYRK1B0.42892203
118CDK150.42845468
119RPS6KA30.40179233
120CAMK2G0.39867637
121MAPKAPK50.38674015
122DYRK30.37247305
123CAMK2D0.36957699
124PDGFRB0.36710720
125ERBB20.36091296
126PRKCQ0.35456762
127RPS6KB10.35449605
128PRKACB0.33791133
129PRKCA0.32310161
130STK38L0.32134708
131CSNK1D0.31409687
132CDK11A0.31112871

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.70906014
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.05561424
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99135713
4Phototransduction_Homo sapiens_hsa047441.91335923
5Butanoate metabolism_Homo sapiens_hsa006501.83477009
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.81349932
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67258049
8GABAergic synapse_Homo sapiens_hsa047271.59817986
9Circadian entrainment_Homo sapiens_hsa047131.59495060
10Nicotine addiction_Homo sapiens_hsa050331.56258000
11Olfactory transduction_Homo sapiens_hsa047401.55906940
12Glutamatergic synapse_Homo sapiens_hsa047241.50824428
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50102697
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45648537
15Arginine biosynthesis_Homo sapiens_hsa002201.44323647
16Propanoate metabolism_Homo sapiens_hsa006401.40924452
17Renin secretion_Homo sapiens_hsa049241.38781876
18Fatty acid metabolism_Homo sapiens_hsa012121.38490511
19Fatty acid degradation_Homo sapiens_hsa000711.37382042
20Morphine addiction_Homo sapiens_hsa050321.36943163
21Long-term potentiation_Homo sapiens_hsa047201.33767601
22Synaptic vesicle cycle_Homo sapiens_hsa047211.30466732
23PPAR signaling pathway_Homo sapiens_hsa033201.25920500
24Amphetamine addiction_Homo sapiens_hsa050311.25816059
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22359147
26Dopaminergic synapse_Homo sapiens_hsa047281.22043372
27Salivary secretion_Homo sapiens_hsa049701.21611412
28Axon guidance_Homo sapiens_hsa043601.19707393
29Cholinergic synapse_Homo sapiens_hsa047251.19572216
30Bile secretion_Homo sapiens_hsa049761.17251641
31Complement and coagulation cascades_Homo sapiens_hsa046101.16422745
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14145425
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12584083
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12511524
35Insulin secretion_Homo sapiens_hsa049111.11565375
36Gastric acid secretion_Homo sapiens_hsa049711.09193369
37Linoleic acid metabolism_Homo sapiens_hsa005911.09169479
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07478457
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07448400
40Oxytocin signaling pathway_Homo sapiens_hsa049211.05383273
41Fatty acid biosynthesis_Homo sapiens_hsa000611.05274550
42Tryptophan metabolism_Homo sapiens_hsa003801.05175988
43Type II diabetes mellitus_Homo sapiens_hsa049301.02329849
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02239979
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99659069
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98787312
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96812940
48Hedgehog signaling pathway_Homo sapiens_hsa043400.94275754
49MAPK signaling pathway_Homo sapiens_hsa040100.93420799
50Fatty acid elongation_Homo sapiens_hsa000620.93265306
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93134792
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92813269
53Cocaine addiction_Homo sapiens_hsa050300.90207935
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90099922
55Serotonergic synapse_Homo sapiens_hsa047260.89821729
56Calcium signaling pathway_Homo sapiens_hsa040200.88549985
57Circadian rhythm_Homo sapiens_hsa047100.87331137
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86734490
59Taste transduction_Homo sapiens_hsa047420.85486486
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85441678
61Long-term depression_Homo sapiens_hsa047300.85342380
62Ether lipid metabolism_Homo sapiens_hsa005650.85141695
63cAMP signaling pathway_Homo sapiens_hsa040240.83426621
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82705529
65Dilated cardiomyopathy_Homo sapiens_hsa054140.80537823
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78736038
67Collecting duct acid secretion_Homo sapiens_hsa049660.78483369
68GnRH signaling pathway_Homo sapiens_hsa049120.78243406
69Dorso-ventral axis formation_Homo sapiens_hsa043200.75317121
70Glucagon signaling pathway_Homo sapiens_hsa049220.74736773
71Peroxisome_Homo sapiens_hsa041460.74492167
72Estrogen signaling pathway_Homo sapiens_hsa049150.73783961
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73564301
74Staphylococcus aureus infection_Homo sapiens_hsa051500.72509307
75Glioma_Homo sapiens_hsa052140.71766802
76Gap junction_Homo sapiens_hsa045400.71459022
77* Regulation of autophagy_Homo sapiens_hsa041400.71425197
78Rap1 signaling pathway_Homo sapiens_hsa040150.69632171
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.68523109
80Pyruvate metabolism_Homo sapiens_hsa006200.68486155
81Prion diseases_Homo sapiens_hsa050200.68473103
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68161843
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67416202
84ErbB signaling pathway_Homo sapiens_hsa040120.66715372
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66619933
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65266398
87beta-Alanine metabolism_Homo sapiens_hsa004100.64600306
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64329457
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63119715
90Basal cell carcinoma_Homo sapiens_hsa052170.63037133
91Hippo signaling pathway_Homo sapiens_hsa043900.62997931
92ABC transporters_Homo sapiens_hsa020100.62354521
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62335712
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61696596
95Steroid biosynthesis_Homo sapiens_hsa001000.61288125
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60465321
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.58745512
98Oocyte meiosis_Homo sapiens_hsa041140.58163431
99Pancreatic secretion_Homo sapiens_hsa049720.57942603
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57705708
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.57595213
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56984899
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56732759
104Starch and sucrose metabolism_Homo sapiens_hsa005000.56640692
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56458655
106Renal cell carcinoma_Homo sapiens_hsa052110.56379546
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.56267083
108Insulin signaling pathway_Homo sapiens_hsa049100.55900867
109Sulfur metabolism_Homo sapiens_hsa009200.54520410
110Insulin resistance_Homo sapiens_hsa049310.54149054
111AMPK signaling pathway_Homo sapiens_hsa041520.52703587
112Glycerolipid metabolism_Homo sapiens_hsa005610.52477865
113Melanogenesis_Homo sapiens_hsa049160.52184646
114Histidine metabolism_Homo sapiens_hsa003400.50114408
115Wnt signaling pathway_Homo sapiens_hsa043100.49809105
116Chemical carcinogenesis_Homo sapiens_hsa052040.48031598
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.47924050
118Endometrial cancer_Homo sapiens_hsa052130.46099307
119Cardiac muscle contraction_Homo sapiens_hsa042600.46045845
120Basal transcription factors_Homo sapiens_hsa030220.45988008
121Thyroid hormone synthesis_Homo sapiens_hsa049180.44117987
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43875787
123Ovarian steroidogenesis_Homo sapiens_hsa049130.43287321
124Choline metabolism in cancer_Homo sapiens_hsa052310.42209499
125* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41508816
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41468190
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40946524
128Ras signaling pathway_Homo sapiens_hsa040140.40652816
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39869751
130VEGF signaling pathway_Homo sapiens_hsa043700.39834351
131Inositol phosphate metabolism_Homo sapiens_hsa005620.39787421
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.39430464
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37102187
134Tight junction_Homo sapiens_hsa045300.34967464

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