ULK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)8.12172263
2axonemal dynein complex assembly (GO:0070286)7.44994563
3* cilium movement (GO:0003341)7.03727156
4cilium or flagellum-dependent cell motility (GO:0001539)6.99775567
5* epithelial cilium movement (GO:0003351)6.82723866
6centriole assembly (GO:0098534)6.45244247
7sperm motility (GO:0030317)6.27916361
8acrosome reaction (GO:0007340)5.65639230
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.53306249
10GTP biosynthetic process (GO:0006183)5.51073656
11fusion of sperm to egg plasma membrane (GO:0007342)5.31282191
12motile cilium assembly (GO:0044458)5.15327435
13acrosome assembly (GO:0001675)5.05596772
14spermatid development (GO:0007286)4.84850598
15regulation of cilium movement (GO:0003352)4.80042167
16cell wall macromolecule metabolic process (GO:0044036)4.70279749
17cell wall macromolecule catabolic process (GO:0016998)4.70279749
18establishment of protein localization to Golgi (GO:0072600)4.67272958
19multicellular organism reproduction (GO:0032504)4.66833893
20UTP biosynthetic process (GO:0006228)4.56886111
21viral transcription (GO:0019083)4.56592565
22sperm-egg recognition (GO:0035036)4.49069673
23* ventricular system development (GO:0021591)4.43977718
24rRNA methylation (GO:0031167)4.41865673
25protein targeting to Golgi (GO:0000042)4.40960578
26translational termination (GO:0006415)4.32475366
27central nervous system myelination (GO:0022010)4.27291238
28axon ensheathment in central nervous system (GO:0032291)4.27291238
29histone mRNA catabolic process (GO:0071044)4.20546549
30microtubule polymerization or depolymerization (GO:0031109)4.17567567
31ribosomal small subunit biogenesis (GO:0042274)4.14625916
32spermatid nucleus differentiation (GO:0007289)4.14349722
33limb bud formation (GO:0060174)4.14083399
34synapsis (GO:0007129)4.06986688
35axoneme assembly (GO:0035082)4.04563778
36binding of sperm to zona pellucida (GO:0007339)4.03718798
37retrograde transport, vesicle recycling within Golgi (GO:0000301)4.00650339
38rRNA modification (GO:0000154)3.97316654
39microtubule depolymerization (GO:0007019)3.95607150
40UTP metabolic process (GO:0046051)3.92988615
41protein polyglutamylation (GO:0018095)3.90049149
42piRNA metabolic process (GO:0034587)3.89444391
43left/right axis specification (GO:0070986)3.86075788
44plasma membrane fusion (GO:0045026)3.85698005
45retinal cone cell development (GO:0046549)3.85655176
46nucleoside diphosphate phosphorylation (GO:0006165)3.85552881
47histone H3-K36 demethylation (GO:0070544)3.83520204
48cell-cell recognition (GO:0009988)3.75243514
49cotranslational protein targeting to membrane (GO:0006613)3.75031708
50regulation of centriole replication (GO:0046599)3.74958266
51histone H3-K9 demethylation (GO:0033169)3.73652350
52reproduction (GO:0000003)3.72697141
53protein targeting to ER (GO:0045047)3.70860503
54protein localization to cilium (GO:0061512)3.70050435
55single strand break repair (GO:0000012)3.68946952
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.68064679
57intraciliary transport (GO:0042073)3.62815618
58regulation of meiosis I (GO:0060631)3.62304269
59single fertilization (GO:0007338)3.58403393
60male meiosis I (GO:0007141)3.56760207
61left/right pattern formation (GO:0060972)3.55365950
62establishment of protein localization to endoplasmic reticulum (GO:0072599)3.53369701
63male meiosis (GO:0007140)3.53094114
64oocyte development (GO:0048599)3.51417931
65regulation of acrosome reaction (GO:0060046)3.48553376
66cellular protein complex disassembly (GO:0043624)3.45355318
67protein localization to endoplasmic reticulum (GO:0070972)3.42155654
68short-term memory (GO:0007614)3.41281089
69CTP biosynthetic process (GO:0006241)3.38355353
70CTP metabolic process (GO:0046036)3.38355353
71* cilium morphogenesis (GO:0060271)3.37335221
72photoreceptor cell maintenance (GO:0045494)3.37109098
73ribosomal large subunit biogenesis (GO:0042273)3.36424530
74cilium organization (GO:0044782)3.30382941
75protein K63-linked deubiquitination (GO:0070536)3.30188124
76endothelium development (GO:0003158)3.29270955
77viral life cycle (GO:0019058)3.24855247
78guanosine-containing compound biosynthetic process (GO:1901070)3.24756765
79cilium assembly (GO:0042384)3.24411404
80reciprocal meiotic recombination (GO:0007131)3.24204751
81reciprocal DNA recombination (GO:0035825)3.24204751
82phosphatidylethanolamine metabolic process (GO:0046337)3.21449890
83regulation of development, heterochronic (GO:0040034)3.19826393
84DNA methylation involved in gamete generation (GO:0043046)3.19154826
85translational elongation (GO:0006414)3.18187205
86protein localization to Golgi apparatus (GO:0034067)3.11320101
87histone exchange (GO:0043486)3.10043813
88phosphatidylethanolamine biosynthetic process (GO:0006646)3.07710317
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05054103
90replication fork processing (GO:0031297)3.04570732
91spermatogenesis (GO:0007283)3.02327952
92protein K11-linked deubiquitination (GO:0035871)3.02241826
93male gamete generation (GO:0048232)3.01223146
94retinal rod cell development (GO:0046548)3.00934784
95sperm capacitation (GO:0048240)2.99695852
96regulation of timing of cell differentiation (GO:0048505)2.99612927
97DNA ligation (GO:0006266)2.95180141
98protein complex disassembly (GO:0043241)2.94602833
99early endosome to late endosome transport (GO:0045022)2.94020907
100chromosome organization involved in meiosis (GO:0070192)2.93663479
101double-strand break repair via homologous recombination (GO:0000724)2.93017461
102RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90666977
103fertilization (GO:0009566)2.90040673
104postsynaptic membrane organization (GO:0001941)2.89351812
105forebrain neuron development (GO:0021884)2.87853465
106DNA replication-dependent nucleosome organization (GO:0034723)2.87307876
107DNA replication-dependent nucleosome assembly (GO:0006335)2.87307876
108negative regulation of inclusion body assembly (GO:0090084)2.86549048
109recombinational repair (GO:0000725)2.85721438
110DNA packaging (GO:0006323)2.85106628
111lateral sprouting from an epithelium (GO:0060601)2.84590282
112response to pheromone (GO:0019236)2.83690168
113gamete generation (GO:0007276)2.83645694
114pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.83465707
115protein K48-linked deubiquitination (GO:0071108)2.83419986
116regulation of chromatin silencing (GO:0031935)2.83262799
117synaptonemal complex organization (GO:0070193)2.83049850
118negative regulation of DNA-dependent DNA replication (GO:2000104)2.81441908
119negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.81177856
120presynaptic membrane assembly (GO:0097105)2.80406091
121nuclear pore complex assembly (GO:0051292)2.79680504
122seminiferous tubule development (GO:0072520)2.79519759
123nonmotile primary cilium assembly (GO:0035058)2.79100883
124regulation of DNA endoreduplication (GO:0032875)2.78601753
125glucosamine-containing compound catabolic process (GO:1901072)2.77271051
126meiotic cell cycle process (GO:1903046)2.76798120
127photoreceptor cell differentiation (GO:0046530)2.75452758
128eye photoreceptor cell differentiation (GO:0001754)2.75452758
129macromolecular complex disassembly (GO:0032984)2.75314546
130meiotic nuclear division (GO:0007126)2.73394906
131germ cell development (GO:0007281)2.72948731
132DNA deamination (GO:0045006)2.71788971
133cardiovascular system development (GO:0072358)2.69910164
134meiosis I (GO:0007127)2.69404347
135embryonic body morphogenesis (GO:0010172)2.69313651
136centrosome organization (GO:0051297)2.66400153
137cellular component assembly involved in morphogenesis (GO:0010927)2.66234905
138translational initiation (GO:0006413)2.65726380
139positive regulation of protein kinase C signaling (GO:0090037)2.64921525
140peptidyl-histidine modification (GO:0018202)2.64914643
141centrosome duplication (GO:0051298)2.64096626
142pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.63556052
143microtubule severing (GO:0051013)2.63118753
144endocardial cushion morphogenesis (GO:0003203)2.61547160
145cell morphogenesis involved in neuron differentiation (GO:0048667)2.60034173
146cell recognition (GO:0008037)2.59875959
147regulation of microtubule-based movement (GO:0060632)2.59544570
148calcium ion-dependent exocytosis (GO:0017156)2.58730387
149monoubiquitinated protein deubiquitination (GO:0035520)2.58617676
150microtubule organizing center organization (GO:0031023)2.55842383
151meiotic cell cycle (GO:0051321)2.53507198
152cellular process involved in reproduction in multicellular organism (GO:0022412)2.52313911
153somite development (GO:0061053)2.52006879
154organic cation transport (GO:0015695)2.50183047
155indolalkylamine catabolic process (GO:0046218)2.50112095
156regulation of cytokine production involved in inflammatory response (GO:1900015)2.47526050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.40946780
2EZH2_22144423_ChIP-Seq_EOC_Human4.81571470
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.49220118
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.40186038
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.08386615
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.98737445
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.79529467
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64687914
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.61376075
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.56464436
11IGF1R_20145208_ChIP-Seq_DFB_Human2.55775651
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44622175
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.31518924
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.26168445
15TAF15_26573619_Chip-Seq_HEK293_Human2.23181397
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.23006789
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.18976074
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12553319
19RNF2_27304074_Chip-Seq_NSC_Mouse2.12321291
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12178153
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05473353
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01747751
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99992146
24VDR_22108803_ChIP-Seq_LS180_Human1.98374196
25CBP_20019798_ChIP-Seq_JUKART_Human1.96461106
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.96461106
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.94264625
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84300799
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82394920
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80593289
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79828269
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77775284
33* STAT3_23295773_ChIP-Seq_U87_Human1.76332999
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74409157
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73289296
36* EZH2_27294783_Chip-Seq_ESCs_Mouse1.69871363
37FUS_26573619_Chip-Seq_HEK293_Human1.67582469
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67489898
39* GBX2_23144817_ChIP-Seq_PC3_Human1.67130058
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66874443
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64809932
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64093339
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63871464
44* TCF4_23295773_ChIP-Seq_U87_Human1.62991673
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61967037
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61705639
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.61594291
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60670502
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59086440
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59015626
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57325025
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57325025
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57157359
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57000392
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.56396196
56EWS_26573619_Chip-Seq_HEK293_Human1.55725589
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53259682
58AR_25329375_ChIP-Seq_VCAP_Human1.49107230
59P53_22387025_ChIP-Seq_ESCs_Mouse1.49082629
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.45826624
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45026705
62NANOG_19829295_ChIP-Seq_ESCs_Human1.43614351
63SOX2_19829295_ChIP-Seq_ESCs_Human1.43614351
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.43148614
65* BCAT_22108803_ChIP-Seq_LS180_Human1.42534290
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.41665618
67P300_18555785_Chip-Seq_ESCs_Mouse1.41217802
68* P300_19829295_ChIP-Seq_ESCs_Human1.40500602
69* SMAD4_21741376_ChIP-Seq_EPCs_Human1.38511243
70ER_23166858_ChIP-Seq_MCF-7_Human1.38040379
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.37410765
72ZNF274_21170338_ChIP-Seq_K562_Hela1.37173075
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36082157
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33975388
75CDX2_22108803_ChIP-Seq_LS180_Human1.33909529
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.33415916
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33223619
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32613871
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31397409
80* SMAD3_21741376_ChIP-Seq_EPCs_Human1.31155120
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30929322
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.28202765
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.27986602
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27191300
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.26497904
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26168745
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25900689
88SALL4_22934838_ChIP-ChIP_CD34+_Human1.25364236
89RUNX2_22187159_ChIP-Seq_PCA_Human1.25101406
90MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23094159
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23091016
92* TCF4_22108803_ChIP-Seq_LS180_Human1.21872129
93TP53_22573176_ChIP-Seq_HFKS_Human1.21441830
94OCT4_18555785_Chip-Seq_ESCs_Mouse1.20981370
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.20158643
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19667892
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19458295
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19458295
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.18907594
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.18519748
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17003054
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16899924
103SOX2_18555785_Chip-Seq_ESCs_Mouse1.16411442
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15255542
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14124928
106NFYB_21822215_ChIP-Seq_K562_Human1.13989054
107TBL1_22424771_ChIP-Seq_293T_Human1.12898306
108SMAD4_21799915_ChIP-Seq_A2780_Human1.12006349
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11693830
110ZFX_18555785_Chip-Seq_ESCs_Mouse1.11565802
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11198023
112E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11194197
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.11065008
114ETV1_20927104_ChIP-Seq_GIST48_Human1.10804624
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10410421
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10188850
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10188850
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10188850
119KLF4_18555785_Chip-Seq_ESCs_Mouse1.10023608
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09963761
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09756927
122PIAS1_25552417_ChIP-Seq_VCAP_Human1.09694512
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09620534
124ESRRB_18555785_Chip-Seq_ESCs_Mouse1.09395424
125RING1B_27294783_Chip-Seq_ESCs_Mouse1.08509780
126RBPJ_21746931_ChIP-Seq_IB4_Human1.07501004
127PHF8_20622853_ChIP-Seq_HELA_Human1.06989730
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06901770
129E2F7_22180533_ChIP-Seq_HELA_Human1.06799840
130TP53_16413492_ChIP-PET_HCT116_Human1.06729108
131TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06207390
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06150253
133* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05828264
134CRX_20693478_ChIP-Seq_RETINA_Mouse1.05639094
135IRF1_19129219_ChIP-ChIP_H3396_Human1.05558963
136GATA3_26560356_Chip-Seq_TH2_Human1.05539323
137TP53_18474530_ChIP-ChIP_U2OS_Human1.05143000
138CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04881492
139HOXB7_26014856_ChIP-Seq_BT474_Human1.04825515
140KDM2B_26808549_Chip-Seq_REH_Human1.04726608
141RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04555135
142HNFA_21074721_ChIP-Seq_CACO-2_Human1.04528985
143AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04186925
144STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03895176
145PU1_27457419_Chip-Seq_LIVER_Mouse1.03792657
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03714862
147RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03579199
148GATA3_26560356_Chip-Seq_TH1_Human1.03101675
149IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02488227
150FOXA1_25329375_ChIP-Seq_VCAP_Human1.02274324
151FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02274324
152* SMRT_27268052_Chip-Seq_Bcells_Human1.01959844
153MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01360325
154* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01088981
155* ERG_20517297_ChIP-Seq_VCAP_Human1.01072803
156TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00024954
157PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99912566
158FLI1_21867929_ChIP-Seq_TH2_Mouse0.99575969
159* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99128548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.80662087
2MP0005410_abnormal_fertilization5.29923976
3MP0000569_abnormal_digit_pigmentation4.65464536
4MP0003136_yellow_coat_color4.22271710
5MP0008057_abnormal_DNA_replication3.85129121
6MP0003718_maternal_effect3.34419435
7MP0003880_abnormal_central_pattern3.16743677
8MP0000566_synostosis2.79564523
9MP0008058_abnormal_DNA_repair2.74682209
10MP0001188_hyperpigmentation2.51977275
11MP0003941_abnormal_skin_development2.43150334
12MP0010030_abnormal_orbit_morphology2.28695185
13MP0000383_abnormal_hair_follicle2.24898111
14MP0002837_dystrophic_cardiac_calcinosis2.20282730
15MP0000427_abnormal_hair_cycle2.19414526
16MP0004381_abnormal_hair_follicle2.17881927
17MP0000049_abnormal_middle_ear2.16508694
18MP0003698_abnormal_male_reproductive2.15652461
19MP0002102_abnormal_ear_morphology2.12906577
20MP0005171_absent_coat_pigmentation2.09634292
21MP0003878_abnormal_ear_physiology2.00593282
22MP0005377_hearing/vestibular/ear_phenot2.00593282
23MP0006276_abnormal_autonomic_nervous1.99248072
24MP0005423_abnormal_somatic_nervous1.94392289
25MP0010094_abnormal_chromosome_stability1.94245602
26MP0003938_abnormal_ear_development1.92741230
27MP0001929_abnormal_gametogenesis1.92458350
28MP0009250_abnormal_appendicular_skeleto1.86582305
29MP0003195_calcinosis1.84702876
30MP0005083_abnormal_biliary_tract1.84529610
31MP0000372_irregular_coat_pigmentation1.82662606
32MP0005075_abnormal_melanosome_morpholog1.82248429
33MP0006292_abnormal_olfactory_placode1.81222302
34MP0000015_abnormal_ear_pigmentation1.78599691
35MP0003950_abnormal_plasma_membrane1.76792909
36MP0005395_other_phenotype1.76292638
37MP0004742_abnormal_vestibular_system1.74590745
38MP0005670_abnormal_white_adipose1.74394187
39MP0005408_hypopigmentation1.72183897
40MP0003252_abnormal_bile_duct1.71479133
41MP0002249_abnormal_larynx_morphology1.68268220
42MP0005409_darkened_coat_color1.61408219
43MP0005623_abnormal_meninges_morphology1.58111329
44MP0003646_muscle_fatigue1.54717282
45MP0000778_abnormal_nervous_system1.54477920
46MP0002282_abnormal_trachea_morphology1.54303251
47MP0005257_abnormal_intraocular_pressure1.54078724
48MP0010678_abnormal_skin_adnexa1.53400899
49MP0002009_preneoplasia1.49784757
50MP0003385_abnormal_body_wall1.48176400
51MP0005310_abnormal_salivary_gland1.47257880
52MP0001346_abnormal_lacrimal_gland1.46267673
53MP0002210_abnormal_sex_determination1.45357409
54MP0003937_abnormal_limbs/digits/tail_de1.41786652
55MP0008004_abnormal_stomach_pH1.39340032
56MP0001984_abnormal_olfaction1.39032838
57MP0001879_abnormal_lymphatic_vessel1.36976471
58MP0009115_abnormal_fat_cell1.36388869
59MP0000026_abnormal_inner_ear1.34359819
60MP0003786_premature_aging1.33915913
61MP0002254_reproductive_system_inflammat1.33643726
62MP0009697_abnormal_copulation1.33607358
63MP0002277_abnormal_respiratory_mucosa1.31384049
64MP0002160_abnormal_reproductive_system1.30647935
65MP0003755_abnormal_palate_morphology1.30245749
66MP0000631_abnormal_neuroendocrine_gland1.29887972
67MP0005085_abnormal_gallbladder_physiolo1.28330256
68MP0001485_abnormal_pinna_reflex1.28257503
69MP0004043_abnormal_pH_regulation1.28205611
70MP0002751_abnormal_autonomic_nervous1.24528502
71MP0003011_delayed_dark_adaptation1.23983631
72MP0004133_heterotaxia1.21366399
73MP0008932_abnormal_embryonic_tissue1.19709849
74MP0003077_abnormal_cell_cycle1.18022602
75MP0008007_abnormal_cellular_replicative1.17817848
76MP0003315_abnormal_perineum_morphology1.15404156
77MP0000762_abnormal_tongue_morphology1.15144824
78MP0001145_abnormal_male_reproductive1.12245400
79MP0002177_abnormal_outer_ear1.11989516
80MP0008789_abnormal_olfactory_epithelium1.10768674
81MP0002163_abnormal_gland_morphology1.09501916
82MP0006072_abnormal_retinal_apoptosis1.09373692
83MP0000613_abnormal_salivary_gland1.09084789
84MP0000467_abnormal_esophagus_morphology1.08528891
85MP0002095_abnormal_skin_pigmentation1.07592305
86MP0005379_endocrine/exocrine_gland_phen1.06994254
87MP0003890_abnormal_embryonic-extraembry1.06308165
88MP0002928_abnormal_bile_duct1.05141095
89MP0003724_increased_susceptibility_to1.04788005
90MP0008995_early_reproductive_senescence1.03288081
91MP0002138_abnormal_hepatobiliary_system1.02690924
92MP0002161_abnormal_fertility/fecundity1.02675358
93MP0001968_abnormal_touch/_nociception1.02595418
94MP0003806_abnormal_nucleotide_metabolis1.02578780
95MP0008877_abnormal_DNA_methylation1.02275956
96MP0000653_abnormal_sex_gland1.01389262
97MP0002876_abnormal_thyroid_physiology1.01301764
98MP0001919_abnormal_reproductive_system1.01019106
99MP0001486_abnormal_startle_reflex1.00558403
100MP0005084_abnormal_gallbladder_morpholo0.98524754
101MP0005365_abnormal_bile_salt0.98259755
102MP0005646_abnormal_pituitary_gland0.98098193
103MP0002116_abnormal_craniofacial_bone0.97034238
104MP0004142_abnormal_muscle_tone0.96919294
105MP0003045_fibrosis0.96824332
106MP0002638_abnormal_pupillary_reflex0.96611763
107MP0010307_abnormal_tumor_latency0.96396568
108MP0001324_abnormal_eye_pigmentation0.95447270
109MP0002557_abnormal_social/conspecific_i0.94142167
110MP0002938_white_spotting0.93001117
111MP0002736_abnormal_nociception_after0.92390974
112MP0009053_abnormal_anal_canal0.91821399
113MP0005551_abnormal_eye_electrophysiolog0.91100593
114MP0005647_abnormal_sex_gland0.90601314
115MP0005389_reproductive_system_phenotype0.90241978
116MP0002752_abnormal_somatic_nervous0.89394988
117MP0002233_abnormal_nose_morphology0.89064350
118MP0010386_abnormal_urinary_bladder0.88980828
119MP0001501_abnormal_sleep_pattern0.88753525
120MP0001340_abnormal_eyelid_morphology0.88007486
121MP0005220_abnormal_exocrine_pancreas0.87566285
122MP0000647_abnormal_sebaceous_gland0.85814687
123MP0000462_abnormal_digestive_system0.85680900
124MP0001666_abnormal_nutrient_absorption0.85014516
125MP0003699_abnormal_female_reproductive0.84816660
126MP0004957_abnormal_blastocyst_morpholog0.83823896
127MP0001986_abnormal_taste_sensitivity0.82938106
128MP0000428_abnormal_craniofacial_morphol0.82908758
129MP0008875_abnormal_xenobiotic_pharmacok0.82670940
130MP0005391_vision/eye_phenotype0.82321098
131MP0003693_abnormal_embryo_hatching0.82266936
132MP0009384_cardiac_valve_regurgitation0.82155224
133MP0001963_abnormal_hearing_physiology0.81494020
134MP0000432_abnormal_head_morphology0.81343541
135MP0000371_diluted_coat_color0.80636510
136MP0002572_abnormal_emotion/affect_behav0.80616035
137MP0001286_abnormal_eye_development0.80298691
138MP0002168_other_aberrant_phenotype0.79683486
139MP0008872_abnormal_physiological_respon0.78889519
140MP0003861_abnormal_nervous_system0.78697391
141MP0005266_abnormal_metabolism0.78559528
142MP0002796_impaired_skin_barrier0.78451435
143MP0002067_abnormal_sensory_capabilities0.78374125
144MP0009046_muscle_twitch0.78250263
145MP0001440_abnormal_grooming_behavior0.77796891
146MP0005174_abnormal_tail_pigmentation0.77715562
147MP0002132_abnormal_respiratory_system0.77668770
148MP0002693_abnormal_pancreas_physiology0.77186005
149MP0001119_abnormal_female_reproductive0.76206892
150MP0002229_neurodegeneration0.75792826
151MP0001905_abnormal_dopamine_level0.75462734
152MP0005248_abnormal_Harderian_gland0.74615710
153MP0002098_abnormal_vibrissa_morphology0.73285318
154MP0005253_abnormal_eye_physiology0.73223137
155MP0002653_abnormal_ependyma_morphology0.72637362
156MP0001299_abnormal_eye_distance/0.71892845
157MP0005499_abnormal_olfactory_system0.71386037
158MP0005394_taste/olfaction_phenotype0.71386037
159MP0000537_abnormal_urethra_morphology0.71091587
160MP0003935_abnormal_craniofacial_develop0.70799132
161MP0003879_abnormal_hair_cell0.70597668
162MP0002734_abnormal_mechanical_nocicepti0.70546163
163MP0002272_abnormal_nervous_system0.70459001
164MP0003787_abnormal_imprinting0.67574649
165MP0005376_homeostasis/metabolism_phenot0.66147417
166MP0005451_abnormal_body_composition0.65396182
167MP0001764_abnormal_homeostasis0.62787153
168MP0003763_abnormal_thymus_physiology0.61609835
169MP0008961_abnormal_basal_metabolism0.58399260
170MP0001765_abnormal_ion_homeostasis0.58244103

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.81390898
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.23431705
3Absent/shortened dynein arms (HP:0200106)7.23431705
4Abnormal respiratory motile cilium physiology (HP:0012261)6.97237017
5Abnormal ciliary motility (HP:0012262)6.21194711
6Abnormal respiratory motile cilium morphology (HP:0005938)6.05512229
7Abnormal respiratory epithelium morphology (HP:0012253)6.05512229
8Rhinitis (HP:0012384)5.34388965
9Chronic hepatic failure (HP:0100626)4.66627611
10Chronic bronchitis (HP:0004469)4.40365239
11Hyperkalemia (HP:0002153)3.48356056
12True hermaphroditism (HP:0010459)3.37254125
13Severe visual impairment (HP:0001141)3.15263462
14Nephronophthisis (HP:0000090)3.12359933
15Cone-rod dystrophy (HP:0000548)3.09844493
16Medial flaring of the eyebrow (HP:0010747)3.02643461
17Chronic sinusitis (HP:0011109)2.96816805
18Pancreatic cysts (HP:0001737)2.92774233
19Concave nail (HP:0001598)2.91287601
20Bony spicule pigmentary retinopathy (HP:0007737)2.90386593
21Pancreatic fibrosis (HP:0100732)2.88529911
22Bronchiectasis (HP:0002110)2.87683816
23Tubulointerstitial nephritis (HP:0001970)2.74712652
24Decreased circulating renin level (HP:0003351)2.73351495
25Infertility (HP:0000789)2.71302842
26Attenuation of retinal blood vessels (HP:0007843)2.67611470
27Reticulocytopenia (HP:0001896)2.67201698
28Abnormal rod and cone electroretinograms (HP:0008323)2.57138205
29Increased circulating renin level (HP:0000848)2.56969763
30Recurrent bronchitis (HP:0002837)2.55667388
31Aplasia involving bones of the upper limbs (HP:0009823)2.53268366
32Aplasia of the phalanges of the hand (HP:0009802)2.53268366
33Aplasia involving bones of the extremities (HP:0009825)2.53268366
34Abnormality of the renal medulla (HP:0100957)2.52737071
35Dyschromatopsia (HP:0007641)2.52516992
36Abnormality of the renal cortex (HP:0011035)2.51470319
37Molar tooth sign on MRI (HP:0002419)2.50503046
38Abnormality of midbrain morphology (HP:0002418)2.50503046
39Abnormality of macular pigmentation (HP:0008002)2.50025914
40Nephrogenic diabetes insipidus (HP:0009806)2.49935093
41Tubulointerstitial abnormality (HP:0001969)2.48161272
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.47046304
43Congenital, generalized hypertrichosis (HP:0004540)2.44756335
44Anencephaly (HP:0002323)2.41392104
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.39289061
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37911055
47Supernumerary spleens (HP:0009799)2.36789395
48Gaze-evoked nystagmus (HP:0000640)2.36364197
49Intestinal atresia (HP:0011100)2.34443507
50Gait imbalance (HP:0002141)2.32714652
51Congenital primary aphakia (HP:0007707)2.28605656
52Abnormality of the nasal mucosa (HP:0000433)2.26650728
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.26169937
54Recurrent sinusitis (HP:0011108)2.25970877
55Congenital sensorineural hearing impairment (HP:0008527)2.25617141
56Abnormal hemoglobin (HP:0011902)2.21738393
57Morphological abnormality of the middle ear (HP:0008609)2.20925145
58Abnormality of chromosome stability (HP:0003220)2.20672621
59Postaxial foot polydactyly (HP:0001830)2.19831650
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17831200
61Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17257115
62Aplasia/Hypoplasia of the lens (HP:0008063)2.16953305
63Macrocytic anemia (HP:0001972)2.16882642
64Chromsome breakage (HP:0040012)2.16704709
65Increased hepatocellular lipid droplets (HP:0006565)2.16605625
66Hyperactive renin-angiotensin system (HP:0000841)2.14053530
67Fair hair (HP:0002286)2.12422927
68Abnormal drinking behavior (HP:0030082)2.11895091
69Polydipsia (HP:0001959)2.11895091
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11225573
71Abnormality of molar morphology (HP:0011070)2.10784652
72Abnormality of molar (HP:0011077)2.10784652
73Congenital hepatic fibrosis (HP:0002612)2.07819478
74Sclerocornea (HP:0000647)2.06304709
75Atelectasis (HP:0100750)2.04789088
76Progressive external ophthalmoplegia (HP:0000590)2.04704303
77Nasal polyposis (HP:0100582)2.01847596
78Portal hypertension (HP:0001409)1.99258473
79Microvesicular hepatic steatosis (HP:0001414)1.98932298
80Septo-optic dysplasia (HP:0100842)1.97181582
81Male infertility (HP:0003251)1.96131634
82Thyroiditis (HP:0100646)1.95856981
83Chin dimple (HP:0010751)1.95731078
84Short tibia (HP:0005736)1.95475108
85Colon cancer (HP:0003003)1.95430912
86Abnormal biliary tract physiology (HP:0012439)1.94769803
87Bile duct proliferation (HP:0001408)1.94769803
88Papillary thyroid carcinoma (HP:0002895)1.94616913
89Progressive cerebellar ataxia (HP:0002073)1.93480418
90Optic disc pallor (HP:0000543)1.93138087
91Abnormality of the dental root (HP:0006486)1.93006479
92Taurodontia (HP:0000679)1.93006479
93Abnormality of permanent molar morphology (HP:0011071)1.93006479
94Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92972740
95Abnormal spermatogenesis (HP:0008669)1.92689623
96Occipital encephalocele (HP:0002085)1.91983262
97Median cleft lip (HP:0000161)1.91896511
98Bronchitis (HP:0012387)1.90517884
99Abdominal situs inversus (HP:0003363)1.90221598
100Abnormality of abdominal situs (HP:0011620)1.90221598
101Coronal craniosynostosis (HP:0004440)1.89582130
102Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88543095
103Abnormality of the fovea (HP:0000493)1.88523446
104Genital tract atresia (HP:0001827)1.88515047
105Vaginal atresia (HP:0000148)1.87498483
106Abnormality of the ileum (HP:0001549)1.86987263
107Abnormality of renal resorption (HP:0011038)1.86927192
108Aplasia/Hypoplasia of the fovea (HP:0008060)1.86131159
109Hypoplasia of the fovea (HP:0007750)1.86131159
110Down-sloping shoulders (HP:0200021)1.86093298
111Preaxial hand polydactyly (HP:0001177)1.85622630
112Abnormality of potassium homeostasis (HP:0011042)1.84693902
113Renal Fanconi syndrome (HP:0001994)1.84688165
114Male pseudohermaphroditism (HP:0000037)1.84641535
115Pallor (HP:0000980)1.82908997
116Renal dysplasia (HP:0000110)1.82903278
117Clubbing of toes (HP:0100760)1.81961666
118Central scotoma (HP:0000603)1.81662264
119Triphalangeal thumb (HP:0001199)1.81430720
120Abnormality of the dental pulp (HP:0006479)1.80799442
121Volvulus (HP:0002580)1.80758130
122Scotoma (HP:0000575)1.80726657
123Cystic liver disease (HP:0006706)1.80687907
124Sloping forehead (HP:0000340)1.80576819
125Abnormality of the hepatic vasculature (HP:0006707)1.78443440
126Sensory axonal neuropathy (HP:0003390)1.78254171
127Abnormal pupillary function (HP:0007686)1.78005492
128Abnormality of the septum pellucidum (HP:0007375)1.77791448
129Hyperthyroidism (HP:0000836)1.77597346
130Upper limb muscle weakness (HP:0003484)1.76751606
131Microglossia (HP:0000171)1.76458015
132Aplasia/hypoplasia of the uterus (HP:0008684)1.74863906
133Retinal dysplasia (HP:0007973)1.73976937
134Megalencephaly (HP:0001355)1.73496146
135Hypoparathyroidism (HP:0000829)1.70295841
136Maternal diabetes (HP:0009800)1.69814504
137Meckel diverticulum (HP:0002245)1.69226012
138Absent septum pellucidum (HP:0001331)1.68768789
139Aganglionic megacolon (HP:0002251)1.68706261
140Oculomotor apraxia (HP:0000657)1.68596258
141Tubular atrophy (HP:0000092)1.67509696
142Cerebellar dysplasia (HP:0007033)1.67213205
143Duplication of thumb phalanx (HP:0009942)1.67081016
144Holoprosencephaly (HP:0001360)1.66799009
145Sex reversal (HP:0012245)1.66514678
146Abnormal sex determination (HP:0012244)1.66514678
147Widely spaced teeth (HP:0000687)1.65684108
148Lipid accumulation in hepatocytes (HP:0006561)1.65579971
149Abnormality of the axillary hair (HP:0100134)1.65119785
150Abnormality of secondary sexual hair (HP:0009888)1.65119785
151Decreased central vision (HP:0007663)1.64342194
152Resting tremor (HP:0002322)1.64257993
153Abnormality of the preputium (HP:0100587)1.62546275
154Polyuria (HP:0000103)1.61546160
155IgM deficiency (HP:0002850)1.59717227
156Gastrointestinal atresia (HP:0002589)1.59616917
157Photophobia (HP:0000613)1.58633367
158Amelogenesis imperfecta (HP:0000705)1.58330262
159Abolished electroretinogram (ERG) (HP:0000550)1.58149440
160Abnormality of chloride homeostasis (HP:0011422)1.57756809
161Renal cortical cysts (HP:0000803)1.56592038
162Generalized hypopigmentation of hair (HP:0011358)1.54844241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.14260015
2FRK4.76648721
3PLK44.18599642
4CASK3.67266908
5ACVR1B3.12820473
6STK393.10076133
7MKNK22.80023674
8ZAK2.78035252
9MAPK152.71829614
10PNCK2.62004853
11BUB12.38640379
12NUAK12.25373468
13MAP4K22.18011390
14EIF2AK32.10639078
15IRAK12.09792585
16BRD42.06999137
17IRAK22.03169565
18FES2.01673870
19STK38L1.95418355
20WNK41.82893785
21BMPR1B1.81394588
22EIF2AK11.76175515
23NEK21.75956417
24DYRK31.74933467
25PIK3CG1.70826384
26INSRR1.67247910
27TNIK1.61870911
28EPHB21.61309174
29TXK1.61104077
30PRKD31.59191758
31SRPK11.58415699
32MKNK11.54581522
33TESK11.53843228
34LATS11.53778063
35PBK1.53064301
36PDK41.49895917
37PDK31.49895917
38NME11.44348056
39STK161.38134741
40PTK2B1.36571730
41CCNB11.34402487
42PINK11.34080662
43CDK81.32788963
44CAMK1G1.32028889
45BRSK21.30214457
46CAMKK21.28692846
47MARK31.28396789
48NEK91.26582400
49NME21.25955501
50BCR1.25611194
51VRK11.25383954
52CDK91.23881119
53WNK31.23357652
54STK381.19688259
55FER1.16610283
56GRK11.16006724
57TAOK31.15863408
58MAP2K71.15542829
59PKN11.14787044
60MELK1.14638261
61TEC1.14429316
62OXSR11.11616906
63DYRK1B1.10098692
64CDK191.09262337
65MST41.07774738
66MAPK131.05336400
67PDK21.05088253
68DYRK21.04805229
69CDK30.97625597
70PRKD20.95151989
71STK30.92246798
72PLK10.88874112
73NLK0.88836159
74CAMK1D0.88471966
75YES10.88427899
76SGK20.84997205
77PRPF4B0.83716333
78STK40.80021625
79UHMK10.76852405
80ADRBK10.76257151
81FGR0.75215576
82DMPK0.73764290
83PLK30.72495775
84MAPKAPK50.72398745
85CDK120.71551654
86STK110.69465905
87ICK0.69331220
88CAMK2A0.69319870
89GRK70.68668309
90TRPM70.68563102
91RPS6KA50.68463396
92CAMK2B0.68099936
93TRIM280.67182494
94MAP3K20.66520203
95NEK60.64469266
96BLK0.64308702
97WEE10.64036716
98TIE10.63610437
99CDC70.63271628
100ATM0.62147564
101ATR0.61868913
102AURKA0.60099530
103PIM20.58020041
104PLK20.56185926
105VRK20.56140369
106ERBB30.55584891
107CSNK1A1L0.55036005
108TGFBR10.54842245
109IRAK30.52547968
110CLK10.52529237
111CHEK20.52204479
112PRKCE0.51910072
113CDK140.51904208
114IRAK40.51211079
115EIF2AK20.50572530
116MUSK0.50447905
117CAMK2D0.50145397
118DYRK1A0.50077307
119MAP2K20.49864212
120NTRK20.45860122
121PIM10.45743257
122MARK10.45651081
123EPHA40.43696991
124IKBKB0.43429417
125IKBKE0.43231033
126AURKB0.42337718
127CHEK10.41548895
128CSK0.41147638
129SGK2230.40769513
130SGK4940.40769513
131ITK0.40287001
132PRKG10.40114369
133CSNK2A10.40090054
134SGK10.39962829
135MINK10.39951841
136PRKAA20.39339550
137MAP3K40.39025533
138WNK10.38863177
139CSNK1D0.38638083
140SYK0.38422472
141CSNK2A20.38068490
142CHUK0.33971153
143BMPR20.33119081
144ROCK20.32937406
145CSNK1G10.31337724
146MAP2K60.31267513
147PRKCG0.30653866
148CSNK1A10.30515174
149BRAF0.30476099
150TTK0.29101820
151EGFR0.28840119
152ADRBK20.28795824
153PRKCQ0.28783559
154PRKACA0.28454154
155CSNK1G30.28290209
156CDK11A0.28226060

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.10330584
2Oxidative phosphorylation_Homo sapiens_hsa001903.10051522
3Protein export_Homo sapiens_hsa030602.82563157
4Huntingtons disease_Homo sapiens_hsa050162.56999233
5Mismatch repair_Homo sapiens_hsa034302.49112374
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46194000
7Parkinsons disease_Homo sapiens_hsa050122.35652819
8Basal transcription factors_Homo sapiens_hsa030222.28948145
9Fanconi anemia pathway_Homo sapiens_hsa034602.18437885
10Alzheimers disease_Homo sapiens_hsa050102.14119434
11Propanoate metabolism_Homo sapiens_hsa006402.02422223
12Olfactory transduction_Homo sapiens_hsa047402.02221953
13RNA degradation_Homo sapiens_hsa030181.95834050
14Phototransduction_Homo sapiens_hsa047441.95734464
15Homologous recombination_Homo sapiens_hsa034401.81608202
16Butanoate metabolism_Homo sapiens_hsa006501.79594654
17Hedgehog signaling pathway_Homo sapiens_hsa043401.76317011
18DNA replication_Homo sapiens_hsa030301.76024708
19Linoleic acid metabolism_Homo sapiens_hsa005911.75681472
20Sphingolipid metabolism_Homo sapiens_hsa006001.73720993
21Nicotine addiction_Homo sapiens_hsa050331.71473044
22Cardiac muscle contraction_Homo sapiens_hsa042601.69831851
23Fatty acid biosynthesis_Homo sapiens_hsa000611.67277011
24ABC transporters_Homo sapiens_hsa020101.66209866
25Basal cell carcinoma_Homo sapiens_hsa052171.65022648
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64966890
27Ether lipid metabolism_Homo sapiens_hsa005651.63116208
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.59720474
29Dorso-ventral axis formation_Homo sapiens_hsa043201.55893054
30Axon guidance_Homo sapiens_hsa043601.49553398
31Base excision repair_Homo sapiens_hsa034101.47625943
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45363753
33Regulation of autophagy_Homo sapiens_hsa041401.45269192
34Proteasome_Homo sapiens_hsa030501.40906872
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40849384
36Circadian rhythm_Homo sapiens_hsa047101.39877530
37Amphetamine addiction_Homo sapiens_hsa050311.38091995
38Wnt signaling pathway_Homo sapiens_hsa043101.37909895
39Nitrogen metabolism_Homo sapiens_hsa009101.32617758
40Arachidonic acid metabolism_Homo sapiens_hsa005901.32369329
41Glutathione metabolism_Homo sapiens_hsa004801.30914145
42RNA polymerase_Homo sapiens_hsa030201.28676965
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28649695
44Tryptophan metabolism_Homo sapiens_hsa003801.27181643
45Chemical carcinogenesis_Homo sapiens_hsa052041.26171206
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26024229
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24413641
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22512733
49Melanogenesis_Homo sapiens_hsa049161.22343941
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.20523527
51Spliceosome_Homo sapiens_hsa030401.20290347
52Sulfur relay system_Homo sapiens_hsa041221.15072757
53Selenocompound metabolism_Homo sapiens_hsa004501.14110902
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13527382
55Primary immunodeficiency_Homo sapiens_hsa053401.12970564
56Serotonergic synapse_Homo sapiens_hsa047261.11660582
57Renin secretion_Homo sapiens_hsa049241.09192645
58Long-term depression_Homo sapiens_hsa047301.06952325
59Vitamin B6 metabolism_Homo sapiens_hsa007501.06575454
60Cell cycle_Homo sapiens_hsa041101.06476360
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05588365
62Taste transduction_Homo sapiens_hsa047421.04321704
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01712336
64Glutamatergic synapse_Homo sapiens_hsa047240.97310375
65Sulfur metabolism_Homo sapiens_hsa009200.94797131
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93684196
67Fatty acid degradation_Homo sapiens_hsa000710.92930598
68Alcoholism_Homo sapiens_hsa050340.92707413
69Caffeine metabolism_Homo sapiens_hsa002320.91505094
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90872252
71beta-Alanine metabolism_Homo sapiens_hsa004100.89568418
72Cocaine addiction_Homo sapiens_hsa050300.89251944
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87091348
74Peroxisome_Homo sapiens_hsa041460.87074390
75One carbon pool by folate_Homo sapiens_hsa006700.85381940
76Nucleotide excision repair_Homo sapiens_hsa034200.82819778
77Oocyte meiosis_Homo sapiens_hsa041140.77720320
78p53 signaling pathway_Homo sapiens_hsa041150.77698033
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77573154
80Ras signaling pathway_Homo sapiens_hsa040140.77128672
81Systemic lupus erythematosus_Homo sapiens_hsa053220.76808720
82Purine metabolism_Homo sapiens_hsa002300.76055542
83Morphine addiction_Homo sapiens_hsa050320.75355377
84Pyrimidine metabolism_Homo sapiens_hsa002400.75087269
85Mineral absorption_Homo sapiens_hsa049780.74409293
86Melanoma_Homo sapiens_hsa052180.74227703
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68726750
88Type I diabetes mellitus_Homo sapiens_hsa049400.67736016
89Long-term potentiation_Homo sapiens_hsa047200.66891855
90Dopaminergic synapse_Homo sapiens_hsa047280.66842645
91Calcium signaling pathway_Homo sapiens_hsa040200.66575803
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66093664
93mRNA surveillance pathway_Homo sapiens_hsa030150.65328336
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65039169
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.64930414
96Circadian entrainment_Homo sapiens_hsa047130.64532412
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.64171364
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62753890
99Gastric acid secretion_Homo sapiens_hsa049710.62400970
100Gap junction_Homo sapiens_hsa045400.61471466
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60452644
102Non-homologous end-joining_Homo sapiens_hsa034500.59826955
103Prostate cancer_Homo sapiens_hsa052150.59089492
104Collecting duct acid secretion_Homo sapiens_hsa049660.58831692
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58457405
106Glycerolipid metabolism_Homo sapiens_hsa005610.58066298
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.57999136
108Ovarian steroidogenesis_Homo sapiens_hsa049130.54867468
109Fatty acid metabolism_Homo sapiens_hsa012120.54391702
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53863686
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53761634
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.53537719
113Hematopoietic cell lineage_Homo sapiens_hsa046400.52355975
114Insulin secretion_Homo sapiens_hsa049110.52135573
115Tight junction_Homo sapiens_hsa045300.51489764
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51326047
117cAMP signaling pathway_Homo sapiens_hsa040240.50872801
118Hippo signaling pathway_Homo sapiens_hsa043900.50617358
119GABAergic synapse_Homo sapiens_hsa047270.50575455
120Salivary secretion_Homo sapiens_hsa049700.48194386
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47940390
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47922918
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47594133
124Autoimmune thyroid disease_Homo sapiens_hsa053200.46125129
125Graft-versus-host disease_Homo sapiens_hsa053320.44449748
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42639080
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.42501393
128Lysine degradation_Homo sapiens_hsa003100.42200072
129Estrogen signaling pathway_Homo sapiens_hsa049150.42035831
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.41526066
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41463941
132Retinol metabolism_Homo sapiens_hsa008300.41372747
133Antigen processing and presentation_Homo sapiens_hsa046120.40644861
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40420541
135TGF-beta signaling pathway_Homo sapiens_hsa043500.40388971
136Renal cell carcinoma_Homo sapiens_hsa052110.38351831
137Viral carcinogenesis_Homo sapiens_hsa052030.37941366
138Cholinergic synapse_Homo sapiens_hsa047250.37678649
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36838125
140Choline metabolism in cancer_Homo sapiens_hsa052310.36215684
141Renin-angiotensin system_Homo sapiens_hsa046140.34698095
142Fatty acid elongation_Homo sapiens_hsa000620.33975297
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.33883843
144ErbB signaling pathway_Homo sapiens_hsa040120.33630999
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33598822
146Herpes simplex infection_Homo sapiens_hsa051680.32511007
147Allograft rejection_Homo sapiens_hsa053300.32476207
148Rheumatoid arthritis_Homo sapiens_hsa053230.32297631
149Pancreatic secretion_Homo sapiens_hsa049720.31780518
150Pathways in cancer_Homo sapiens_hsa052000.30030705
151Histidine metabolism_Homo sapiens_hsa003400.29754836
152Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28454064
153cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28167519
154Rap1 signaling pathway_Homo sapiens_hsa040150.27319678
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.27027338
156RNA transport_Homo sapiens_hsa030130.26984022
157SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26858646
158Bladder cancer_Homo sapiens_hsa052190.25280835
159Metabolic pathways_Homo sapiens_hsa011000.25002200

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