ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	aggressive behavior (GO:0002118)	4.88236144
2	immunoglobulin mediated immune response (GO:0016064)	4.20513790
3	indolalkylamine metabolic process (GO:0006586)	4.08582794
4	indolalkylamine catabolic process (GO:0046218)	3.90042020
5	tryptophan catabolic process (GO:0006569)	3.90042020
6	indole-containing compound catabolic process (GO:0042436)	3.90042020
7	negative regulation of growth of symbiont in host (GO:0044130)	3.68679205
8	negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	3.68679205
9	modulation of growth of symbiont involved in interaction with host (GO:0044144)	3.68679205
10	regulation of growth of symbiont in host (GO:0044126)	3.68679205
11	platelet dense granule organization (GO:0060155)	3.67683460
12	purine-containing compound salvage (GO:0043101)	3.67440169
13	purine nucleotide salvage (GO:0032261)	3.62878889
14	B cell mediated immunity (GO:0019724)	3.59297677
15	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.54683038
16	positive regulation of antigen processing and presentation (GO:0002579)	3.52321889
17	tryptophan metabolic process (GO:0006568)	3.52154330
18	negative regulation of chemokine production (GO:0032682)	3.51720424
19	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.47969572
20	inositol phosphate catabolic process (GO:0071545)	3.41149188
21	purine deoxyribonucleotide catabolic process (GO:0009155)	3.21564362
22	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.19724808
23	DNA double-strand break processing (GO:0000729)	3.17819993
24	hyperosmotic salinity response (GO:0042538)	3.16248274
25	centriole assembly (GO:0098534)	3.14167991
26	regulation of antigen processing and presentation (GO:0002577)	3.11904646
27	response to peptidoglycan (GO:0032494)	3.11560102
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.08593791
29	centriole replication (GO:0007099)	3.03593120
30	regulation of chemokine biosynthetic process (GO:0045073)	3.02448251
31	piRNA metabolic process (GO:0034587)	3.01948787
32	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.97061849
33	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.95423640
34	deoxyribonucleotide catabolic process (GO:0009264)	2.93616466
35	positive regulation of B cell differentiation (GO:0045579)	2.92807616
36	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.91501911
37	regulation of penile erection (GO:0060405)	2.90048328
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.88278850
39	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.88278850
40	NADH dehydrogenase complex assembly (GO:0010257)	2.88278850
41	regulation of dendritic cell antigen processing and presentation (GO:0002604)	2.88091093
42	protein complex biogenesis (GO:0070271)	2.86274484
43	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.85949805
44	inositol phosphate dephosphorylation (GO:0046855)	2.85949805
45	seminiferous tubule development (GO:0072520)	2.85217478
46	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.84235652
47	purine nucleobase biosynthetic process (GO:0009113)	2.82624736
48	DNA deamination (GO:0045006)	2.82298560
49	definitive hemopoiesis (GO:0060216)	2.75560414
50	deoxyribose phosphate catabolic process (GO:0046386)	2.75010943
51	ubiquinone biosynthetic process (GO:0006744)	2.71941558
52	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.70344511
53	mitochondrial respiratory chain complex assembly (GO:0033108)	2.69534920
54	grooming behavior (GO:0007625)	2.68218438
55	aldehyde catabolic process (GO:0046185)	2.66992417
56	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.63819885
57	alkaloid metabolic process (GO:0009820)	2.63156027
58	negative regulation of B cell apoptotic process (GO:0002903)	2.61474491
59	histone H3-K9 methylation (GO:0051567)	2.61098834
60	ATP synthesis coupled proton transport (GO:0015986)	2.59594850
61	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.59594850
62	response to UV-C (GO:0010225)	2.59354249
63	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.56838534
64	proteasome assembly (GO:0043248)	2.56062437
65	relaxation of smooth muscle (GO:0044557)	2.55403905
66	mismatch repair (GO:0006298)	2.54124650
67	poly(A)+ mRNA export from nucleus (GO:0016973)	2.53681621
68	GPI anchor biosynthetic process (GO:0006506)	2.53320020
69	DNA catabolic process, exonucleolytic (GO:0000738)	2.50169849
70	positive regulation of megakaryocyte differentiation (GO:0045654)	2.50096215
71	chaperone-mediated protein transport (GO:0072321)	2.49967090
72	cell wall macromolecule catabolic process (GO:0016998)	2.49406771
73	kynurenine metabolic process (GO:0070189)	2.48671350
74	indole-containing compound metabolic process (GO:0042430)	2.47920577
75	GPI anchor metabolic process (GO:0006505)	2.47355703
76	neutrophil mediated immunity (GO:0002446)	2.46531279
77	mannosylation (GO:0097502)	2.45280027
78	base-excision repair, AP site formation (GO:0006285)	2.44878637
79	positive regulation of interleukin-17 production (GO:0032740)	2.44254552
80	response to pheromone (GO:0019236)	2.43537094
81	adenosine metabolic process (GO:0046085)	2.42394160
82	purine deoxyribonucleotide metabolic process (GO:0009151)	2.41889565
83	regulation of germinal center formation (GO:0002634)	2.41418853
84	cell wall macromolecule metabolic process (GO:0044036)	2.40647693
85	nucleotide salvage (GO:0043173)	2.40193889
86	defense response to protozoan (GO:0042832)	2.37980351
87	response to protozoan (GO:0001562)	2.37943080
88	microglial cell activation (GO:0001774)	2.37242821
89	polyol catabolic process (GO:0046174)	2.37085600
90	DNA ligation (GO:0006266)	2.36777403
91	response to interferon-beta (GO:0035456)	2.36760008
92	positive regulation of protein homodimerization activity (GO:0090073)	2.36013910
93	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	2.35361099
94	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	2.35361099
95	regulation of B cell apoptotic process (GO:0002902)	2.35160807
96	positive regulation of prostaglandin secretion (GO:0032308)	2.33033498
97	DNA methylation involved in gamete generation (GO:0043046)	2.32843711
98	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	2.31519693
99	ubiquinone metabolic process (GO:0006743)	2.31489009
100	positive regulation of type 2 immune response (GO:0002830)	2.31308412

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.77301755
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.70455235
3	VDR_22108803_ChIP-Seq_LS180_Human	3.44739003
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.40729016
5	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.33571421
6	IGF1R_20145208_ChIP-Seq_DFB_Human	3.22615403
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.07183850
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.79668423
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.78681679
10	E2F7_22180533_ChIP-Seq_HELA_Human	2.66524162
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.55974002
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.50913567
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.36849443
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.34945374
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.33514138
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.29682098
17	SCL_19346495_ChIP-Seq_HPC-7_Human	2.28887760
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.23120767
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.05601337
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.97468684
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.89523663
22	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.79520241
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.75410069
24	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.73902598
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.73823240
26	EWS_26573619_Chip-Seq_HEK293_Human	1.70289436
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.68276823
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.65197647
29	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.64949933
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.64546719
31	SPI1_23547873_ChIP-Seq_NB4_Human	1.63895811
32	FUS_26573619_Chip-Seq_HEK293_Human	1.63573549
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.57344353
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.52700662
35	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.51249495
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50026933
37	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.46762149
38	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.45834842
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.45613276
40	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.43619199
41	MYB_26560356_Chip-Seq_TH2_Human	1.42378549
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.41823165
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38987296
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.37819655
45	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36178127
46	CIITA_25753668_ChIP-Seq_RAJI_Human	1.36010275
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.34946173
48	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.31081314
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.30469654
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30225974
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30225974
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.29976408
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.29349586
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29349586
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28212330
56	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.27867551
57	P300_19829295_ChIP-Seq_ESCs_Human	1.26271061
58	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.26180521
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25977686
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25977686
61	GABP_19822575_ChIP-Seq_HepG2_Human	1.25611274
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.25608022
63	GATA3_26560356_Chip-Seq_TH2_Human	1.24087372
64	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.24075026
65	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.20532814
66	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.16944737
67	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.14782603
68	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.13144419
69	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.11536565
70	GATA3_27048872_Chip-Seq_THYMUS_Human	1.10985234
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10957141
72	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10557451
73	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.09772328
74	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.07975519
75	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.07680179
76	AR_20517297_ChIP-Seq_VCAP_Human	1.06294677
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06076633
78	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.05809421
79	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.05312133
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04410412
81	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.03752597
82	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.02086700
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02043136
84	DCP1A_22483619_ChIP-Seq_HELA_Human	1.01672911
85	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.99136670
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98704430
87	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.97790915
88	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.96692016
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96008053
90	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.95898778
91	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95749162
92	NCOR_22424771_ChIP-Seq_293T_Human	0.94066153
93	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.94039456
94	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.93179630
95	TTF2_22483619_ChIP-Seq_HELA_Human	0.92767294
96	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.89081181
97	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.89065433
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.85712951
99	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.84671888
100	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.84269466

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.09279352
2	MP0001835_abnormal_antigen_presentation	3.91673877
3	MP0005645_abnormal_hypothalamus_physiol	2.59819416
4	MP0005397_hematopoietic_system_phenotyp	2.55372388
5	MP0001545_abnormal_hematopoietic_system	2.55372388
6	MP0000569_abnormal_digit_pigmentation	2.41794305
7	MP0008058_abnormal_DNA_repair	2.38731976
8	MP0009278_abnormal_bone_marrow	2.35466806
9	MP0005075_abnormal_melanosome_morpholog	2.33518303
10	MP0006036_abnormal_mitochondrial_physio	2.32801805
11	MP0009697_abnormal_copulation	2.31736962
12	MP0004147_increased_porphyrin_level	2.22541176
13	MP0003880_abnormal_central_pattern	2.22254563
14	MP0002396_abnormal_hematopoietic_system	2.18153060
15	MP0002132_abnormal_respiratory_system	2.12383699
16	MP0005084_abnormal_gallbladder_morpholo	2.06967073
17	MP0006035_abnormal_mitochondrial_morpho	2.06130309
18	MP0005464_abnormal_platelet_physiology	1.94079611
19	MP0005410_abnormal_fertilization	1.90482092
20	MP0005646_abnormal_pituitary_gland	1.89527164
21	MP0000465_gastrointestinal_hemorrhage	1.86874980
22	MP0003172_abnormal_lysosome_physiology	1.86548203
23	MP0010094_abnormal_chromosome_stability	1.85730195
24	MP0001529_abnormal_vocalization	1.83467856
25	MP0006292_abnormal_olfactory_placode	1.78853105
26	MP0002148_abnormal_hypersensitivity_rea	1.73780454
27	MP0005174_abnormal_tail_pigmentation	1.70278571
28	MP0001764_abnormal_homeostasis	1.69357435
29	MP0003718_maternal_effect	1.65639167
30	MP0008007_abnormal_cellular_replicative	1.57330944
31	MP0000015_abnormal_ear_pigmentation	1.56546864
32	MP0009785_altered_susceptibility_to	1.54103155
33	MP0003303_peritoneal_inflammation	1.50709993
34	MP0003183_abnormal_peptide_metabolism	1.49138752
35	MP0008877_abnormal_DNA_methylation	1.36424530
36	MP0002419_abnormal_innate_immunity	1.32182464
37	MP0004808_abnormal_hematopoietic_stem	1.32049345
38	MP0008004_abnormal_stomach_pH	1.29915462
39	MP0001800_abnormal_humoral_immune	1.27942474
40	MP0002837_dystrophic_cardiac_calcinosis	1.26105867
41	MP0005025_abnormal_response_to	1.24610502
42	MP0006072_abnormal_retinal_apoptosis	1.20536013
43	MP0003195_calcinosis	1.19471243
44	MP0002452_abnormal_antigen_presenting	1.19008451
45	MP0005220_abnormal_exocrine_pancreas	1.17390804
46	MP0001819_abnormal_immune_cell	1.15239594
47	MP0002420_abnormal_adaptive_immunity	1.14466150
48	MP0003786_premature_aging	1.13582551
49	MP0009764_decreased_sensitivity_to	1.13038275
50	MP0008872_abnormal_physiological_respon	1.11213547
51	MP0002735_abnormal_chemical_nociception	1.10973437
52	MP0002723_abnormal_immune_serum	1.10776511
53	MP0003186_abnormal_redox_activity	1.10125266
54	MP0000681_abnormal_thyroid_gland	1.07479876
55	MP0000689_abnormal_spleen_morphology	1.06801702
56	MP0002095_abnormal_skin_pigmentation	1.06482118
57	MP0002009_preneoplasia	1.04698438
58	MP0002398_abnormal_bone_marrow	1.04441651
59	MP0005000_abnormal_immune_tolerance	1.03337490
60	MP0001905_abnormal_dopamine_level	1.02969177
61	MP0003724_increased_susceptibility_to	1.00658523
62	MP0006276_abnormal_autonomic_nervous	1.00056637
63	MP0002006_tumorigenesis	0.99279752
64	MP0005535_abnormal_body_temperature	0.94549688
65	MP0001986_abnormal_taste_sensitivity	0.94463001
66	MP0001968_abnormal_touch/_nociception	0.94063862
67	MP0005423_abnormal_somatic_nervous	0.93449576
68	MP0001929_abnormal_gametogenesis	0.93401226
69	MP0004142_abnormal_muscle_tone	0.93323621
70	MP0000372_irregular_coat_pigmentation	0.93229630
71	MP0000716_abnormal_immune_system	0.92772655
72	MP0002722_abnormal_immune_system	0.92694203
73	MP0005551_abnormal_eye_electrophysiolog	0.90847367
74	MP0005671_abnormal_response_to	0.89548370
75	MP0010386_abnormal_urinary_bladder	0.88451293
76	MP0002429_abnormal_blood_cell	0.87017793
77	MP0002090_abnormal_vision	0.86819918
78	MP0002160_abnormal_reproductive_system	0.86565712
79	MP0002139_abnormal_hepatobiliary_system	0.83826460
80	MP0008260_abnormal_autophagy	0.83803122
81	MP0000358_abnormal_cell_content/	0.82548501
82	MP0002019_abnormal_tumor_incidence	0.81378705
83	MP0005253_abnormal_eye_physiology	0.79470186
84	MP0003698_abnormal_male_reproductive	0.78436118
85	MP0000230_abnormal_systemic_arterial	0.78069399
86	MP0009765_abnormal_xenobiotic_induced	0.77939329
87	MP0003787_abnormal_imprinting	0.77521026
88	MP0008469_abnormal_protein_level	0.76291639
89	MP0005058_abnormal_lysosome_morphology	0.75391247
90	MP0001790_abnormal_immune_system	0.74926485
91	MP0005387_immune_system_phenotype	0.74926485
92	MP0003693_abnormal_embryo_hatching	0.74558915
93	MP0008873_increased_physiological_sensi	0.74337180
94	MP0001501_abnormal_sleep_pattern	0.74036948
95	MP0005360_urolithiasis	0.73760898
96	MP0002166_altered_tumor_susceptibility	0.70240763
97	MP0001845_abnormal_inflammatory_respons	0.68340343
98	MP0005647_abnormal_sex_gland	0.66798765
99	MP0008995_early_reproductive_senescence	0.65712381
100	MP0005266_abnormal_metabolism	0.65708101

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute lymphatic leukemia (HP:0006721)	4.19962938
2	Increased intramyocellular lipid droplets (HP:0012240)	3.53070340
3	Lipid accumulation in hepatocytes (HP:0006561)	3.49343473
4	Hepatocellular necrosis (HP:0001404)	3.48497792
5	Increased hepatocellular lipid droplets (HP:0006565)	3.42856232
6	3-Methylglutaconic aciduria (HP:0003535)	3.42208337
7	Hypothermia (HP:0002045)	3.40580030
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.38474812
9	Thrombocytosis (HP:0001894)	3.37404222
10	Hepatic necrosis (HP:0002605)	3.36120014
11	Mitochondrial inheritance (HP:0001427)	3.31264601
12	Acute necrotizing encephalopathy (HP:0006965)	3.29261443
13	Aplastic anemia (HP:0001915)	3.29234327
14	Elevated erythrocyte sedimentation rate (HP:0003565)	3.28618427
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.28530713
16	Increased muscle lipid content (HP:0009058)	3.27758044
17	Renal Fanconi syndrome (HP:0001994)	3.17236127
18	Medial flaring of the eyebrow (HP:0010747)	2.99923900
19	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.97193814
20	Absent/shortened dynein arms (HP:0200106)	2.97193814
21	Exertional dyspnea (HP:0002875)	2.87436840
22	Increased CSF lactate (HP:0002490)	2.86737153
23	Progressive macrocephaly (HP:0004481)	2.86665857
24	Cerebellar dysplasia (HP:0007033)	2.77987036
25	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.76987249
26	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.76987249
27	Acute encephalopathy (HP:0006846)	2.76215863
28	Abnormality of the prostate (HP:0008775)	2.73727074
29	Chronic obstructive pulmonary disease (HP:0006510)	2.57593234
30	Obstructive lung disease (HP:0006536)	2.57593234
31	Type II lissencephaly (HP:0007260)	2.55569494
32	Abnormal pupillary function (HP:0007686)	2.49672798
33	Cerebral palsy (HP:0100021)	2.47234014
34	Abnormality of B cell number (HP:0010975)	2.46403881
35	B lymphocytopenia (HP:0010976)	2.41334239
36	Dicarboxylic aciduria (HP:0003215)	2.31527592
37	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.31527592
38	Median cleft lip (HP:0000161)	2.31055120
39	Pancreatic cysts (HP:0001737)	2.30622949
40	Abnormal respiratory epithelium morphology (HP:0012253)	2.30530864
41	Abnormal respiratory motile cilium morphology (HP:0005938)	2.30530864
42	Type I transferrin isoform profile (HP:0003642)	2.30402166
43	Petechiae (HP:0000967)	2.29078811
44	Multiple enchondromatosis (HP:0005701)	2.27128469
45	Increased serum lactate (HP:0002151)	2.26438478
46	Limb hypertonia (HP:0002509)	2.24994514
47	Abnormality of midbrain morphology (HP:0002418)	2.24585118
48	Molar tooth sign on MRI (HP:0002419)	2.24585118
49	Agammaglobulinemia (HP:0004432)	2.23413499
50	Eosinophilia (HP:0001880)	2.22571405
51	Abnormal ciliary motility (HP:0012262)	2.21416632
52	Abnormality of male internal genitalia (HP:0000022)	2.20958420
53	Abnormal rod and cone electroretinograms (HP:0008323)	2.16074328
54	Lactic acidosis (HP:0003128)	2.15974397
55	Granulocytopenia (HP:0001913)	2.13955584
56	Hyperglycinemia (HP:0002154)	2.13185215
57	True hermaphroditism (HP:0010459)	2.13131930
58	Methylmalonic acidemia (HP:0002912)	2.13032188
59	Abolished electroretinogram (ERG) (HP:0000550)	2.10706812
60	Cerebral edema (HP:0002181)	2.09271429
61	Pancreatic fibrosis (HP:0100732)	2.06963772
62	Stomatitis (HP:0010280)	2.05852228
63	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.05810841
64	Abnormal protein N-linked glycosylation (HP:0012347)	2.05810841
65	Abnormal protein glycosylation (HP:0012346)	2.05810841
66	Abnormal glycosylation (HP:0012345)	2.05810841
67	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.05220851
68	Respiratory difficulties (HP:0002880)	2.04170509
69	Myositis (HP:0100614)	2.03611219
70	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.02276109
71	Methylmalonic aciduria (HP:0012120)	2.00957904
72	Decreased central vision (HP:0007663)	1.97256085
73	Abnormality of DNA repair (HP:0003254)	1.96624794
74	Reduced antithrombin III activity (HP:0001976)	1.95386746
75	Attenuation of retinal blood vessels (HP:0007843)	1.95187182
76	Retinal dysplasia (HP:0007973)	1.94020436
77	Dyschromatopsia (HP:0007641)	1.89976394
78	Abnormality of the pleura (HP:0002103)	1.89391060
79	Type 2 muscle fiber atrophy (HP:0003554)	1.85158675
80	Exercise intolerance (HP:0003546)	1.84076618
81	Congenital primary aphakia (HP:0007707)	1.83057204
82	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.82983127
83	Carpal bone hypoplasia (HP:0001498)	1.82853959
84	Abnormality of renal resorption (HP:0011038)	1.82060635
85	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.81965094
86	Emotional lability (HP:0000712)	1.81856673
87	Renal cortical cysts (HP:0000803)	1.79890298
88	Xerostomia (HP:0000217)	1.79255664
89	Optic disc pallor (HP:0000543)	1.77439460
90	Respiratory failure (HP:0002878)	1.76196070
91	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.76141461
92	Volvulus (HP:0002580)	1.75364000
93	Meningitis (HP:0001287)	1.74826516
94	Hyperglycinuria (HP:0003108)	1.73588188
95	Panhypogammaglobulinemia (HP:0003139)	1.72951701
96	Abnormality of glycolysis (HP:0004366)	1.72468547
97	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.72403769
98	Chromsome breakage (HP:0040012)	1.72143754
99	Abnormality of eosinophils (HP:0001879)	1.69556085
100	Gait imbalance (HP:0002141)	1.68634045

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FLT3	3.81569923
2	TAOK3	3.26546921
3	CDK19	2.98731431
4	BCKDK	2.95254731
5	MAP4K2	2.84065957
6	KIT	2.74577948
7	PINK1	2.47674843
8	BMPR2	2.09366133
9	ZAK	2.03530085
10	CCNB1	2.03487203
11	VRK2	1.95792001
12	FRK	1.92541157
13	TESK2	1.88917579
14	EIF2AK3	1.81098485
15	NUAK1	1.77217296
16	ADRBK2	1.75736609
17	SCYL2	1.73648658
18	BMPR1B	1.73521842
19	TEC	1.70382337
20	MAP4K1	1.68875726
21	CSF1R	1.68709790
22	KDR	1.63581930
23	TLK1	1.52593122
24	MAP3K13	1.44965721
25	PLK4	1.38793969
26	RPS6KA4	1.38166514
27	PBK	1.33808115
28	MAP2K3	1.27606450
29	NME2	1.27460677
30	MKNK1	1.24234652
31	CDC7	1.22235643
32	FES	1.19456872
33	CSNK1G3	1.17701572
34	ACVR1B	1.10332351
35	PIM2	1.09669446
36	TBK1	1.09319008
37	TNK2	1.08986175
38	OXSR1	1.05214613
39	WEE1	1.02908240
40	VRK1	1.02091634
41	MST4	1.01056878
42	ATR	0.99838605
43	CSNK1A1L	0.99328148
44	SRPK1	0.98827406
45	SYK	0.98797895
46	MARK3	0.96758331
47	TXK	0.96686355
48	CSNK1G2	0.96315859
49	IKBKB	0.95306115
50	GRK1	0.95269981
51	TIE1	0.95084004
52	BTK	0.90271597
53	RPS6KA5	0.89784841
54	CDK7	0.85304257
55	CSNK1G1	0.81515329
56	NEK1	0.78736776
57	ITK	0.78444246
58	LYN	0.78280411
59	STK16	0.75858166
60	CDK3	0.74205653
61	PRKCQ	0.72357367
62	TGFBR1	0.72143563
63	MKNK2	0.71841846
64	NEK2	0.71716060
65	PIK3CG	0.71390811
66	EIF2AK2	0.68110322
67	PLK1	0.62634563
68	MAP3K7	0.60910270
69	MAP2K6	0.58941579
70	MAPK13	0.58234033
71	CHEK2	0.55516067
72	ERBB3	0.53102914
73	IKBKE	0.52669470
74	AURKB	0.52397973
75	ATM	0.52297819
76	RIPK4	0.51993246
77	ERN1	0.51506820
78	DAPK1	0.50755507
79	WNK3	0.49840216
80	OBSCN	0.49184416
81	ADRBK1	0.48924752
82	CDK8	0.48624543
83	WNK4	0.47338771
84	LCK	0.45955904
85	INSRR	0.45922678
86	GRK6	0.44307820
87	CSNK2A1	0.42732086
88	BRD4	0.42426660
89	STK39	0.39938313
90	MYLK	0.39847626
91	IGF1R	0.39156922
92	HCK	0.38478976
93	CSNK2A2	0.37619232
94	MAP3K14	0.36874072
95	GRK7	0.36386485
96	CLK1	0.35396553
97	JAK3	0.35270522
98	PTK2B	0.34960676
99	MATK	0.34728984
100	PIM1	0.31861717

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.41929048
2	Allograft rejection_Homo sapiens_hsa05330	3.48278815
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.34698564
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.27984570
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.16898003
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.81876728
7	Protein export_Homo sapiens_hsa03060	2.55713786
8	Base excision repair_Homo sapiens_hsa03410	2.18288909
9	Homologous recombination_Homo sapiens_hsa03440	2.15061398
10	DNA replication_Homo sapiens_hsa03030	2.04898536
11	Antigen processing and presentation_Homo sapiens_hsa04612	1.94203551
12	Non-homologous end-joining_Homo sapiens_hsa03450	1.90799518
13	RNA polymerase_Homo sapiens_hsa03020	1.87204518
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.83856002
15	Rheumatoid arthritis_Homo sapiens_hsa05323	1.80395459
16	Fatty acid elongation_Homo sapiens_hsa00062	1.75706117
17	Leishmaniasis_Homo sapiens_hsa05140	1.74157865
18	Parkinsons disease_Homo sapiens_hsa05012	1.73680812
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.71725661
20	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.69620752
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.60745781
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.59334873
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.49465064
24	Proteasome_Homo sapiens_hsa03050	1.49000588
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.48317992
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.45577386
27	Viral myocarditis_Homo sapiens_hsa05416	1.41233262
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.33632598
29	Ribosome_Homo sapiens_hsa03010	1.33174657
30	Mismatch repair_Homo sapiens_hsa03430	1.32437730
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.29268949
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.27289427
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27249373
34	Peroxisome_Homo sapiens_hsa04146	1.26933895
35	Propanoate metabolism_Homo sapiens_hsa00640	1.22134955
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.21731075
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.19096109
38	Regulation of autophagy_Homo sapiens_hsa04140	1.15470797
39	Herpes simplex infection_Homo sapiens_hsa05168	1.08797700
40	Butanoate metabolism_Homo sapiens_hsa00650	1.08622838
41	Olfactory transduction_Homo sapiens_hsa04740	1.07647531
42	Primary immunodeficiency_Homo sapiens_hsa05340	1.05516574
43	RNA degradation_Homo sapiens_hsa03018	1.05145760
44	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.01757396
45	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.00580992
46	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.99858636
47	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.98750243
48	Purine metabolism_Homo sapiens_hsa00230	0.96045721
49	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.95127116
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.91440477
51	Spliceosome_Homo sapiens_hsa03040	0.91093769
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88970698
53	Basal transcription factors_Homo sapiens_hsa03022	0.87481366
54	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.83089095
55	Huntingtons disease_Homo sapiens_hsa05016	0.81884647
56	African trypanosomiasis_Homo sapiens_hsa05143	0.78487214
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.76159407
58	Phototransduction_Homo sapiens_hsa04744	0.75327240
59	Fatty acid degradation_Homo sapiens_hsa00071	0.71040591
60	RNA transport_Homo sapiens_hsa03013	0.68324960
61	Alzheimers disease_Homo sapiens_hsa05010	0.67954222
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.67667531
63	Tyrosine metabolism_Homo sapiens_hsa00350	0.66413701
64	Influenza A_Homo sapiens_hsa05164	0.66074405
65	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.62382911
66	Tuberculosis_Homo sapiens_hsa05152	0.61476539
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.60920589
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.60194258
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59853803
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58811785
71	Phagosome_Homo sapiens_hsa04145	0.57355327
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.54071820
73	Legionellosis_Homo sapiens_hsa05134	0.53354621
74	Metabolic pathways_Homo sapiens_hsa01100	0.52927435
75	Phenylalanine metabolism_Homo sapiens_hsa00360	0.51135932
76	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.49704848
77	Linoleic acid metabolism_Homo sapiens_hsa00591	0.49679428
78	Toxoplasmosis_Homo sapiens_hsa05145	0.48795620
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.48192552
80	Glutathione metabolism_Homo sapiens_hsa00480	0.47274507
81	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.46911665
82	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.44360555
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43799504
84	Salivary secretion_Homo sapiens_hsa04970	0.43760369
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.43320355
86	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.41771193
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41185373
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40350790
89	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.39741416
90	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.39051153
91	Pentose phosphate pathway_Homo sapiens_hsa00030	0.37966437
92	Carbon metabolism_Homo sapiens_hsa01200	0.37250744
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36905972
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36518921
95	Pertussis_Homo sapiens_hsa05133	0.34305146
96	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33112563
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24753152
98	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.20153070
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.19827294
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.19494003

ULK4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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