ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.30051243
2	aggressive behavior (GO:0002118)	4.51544253
3	tryptophan catabolic process (GO:0006569)	4.00482453
4	indole-containing compound catabolic process (GO:0042436)	4.00482453
5	indolalkylamine catabolic process (GO:0046218)	4.00482453
6	tryptophan metabolic process (GO:0006568)	3.86265851
7	cell wall macromolecule catabolic process (GO:0016998)	3.78802903
8	base-excision repair, AP site formation (GO:0006285)	3.68436106
9	ubiquinone biosynthetic process (GO:0006744)	3.59295606
10	DNA deamination (GO:0045006)	3.57857705
11	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.53268003
12	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.49867786
13	ubiquinone metabolic process (GO:0006743)	3.49828667
14	mismatch repair (GO:0006298)	3.49007702
15	purine deoxyribonucleotide catabolic process (GO:0009155)	3.45815817
16	indolalkylamine metabolic process (GO:0006586)	3.42720791
17	cell wall macromolecule metabolic process (GO:0044036)	3.34554716
18	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.31779192
19	DNA catabolic process, exonucleolytic (GO:0000738)	3.27435071
20	regulation of cilium movement (GO:0003352)	3.20070027
21	spermatid development (GO:0007286)	3.16479772
22	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.10697003
23	centriole replication (GO:0007099)	3.09213366
24	sperm motility (GO:0030317)	3.05402035
25	piRNA metabolic process (GO:0034587)	3.05204430
26	deoxyribonucleotide catabolic process (GO:0009264)	3.04198944
27	synapsis (GO:0007129)	3.01822285
28	AMP metabolic process (GO:0046033)	3.00868937
29	organic cation transport (GO:0015695)	3.00504432
30	recombinational repair (GO:0000725)	2.98607124
31	male meiosis (GO:0007140)	2.98401900
32	replication fork processing (GO:0031297)	2.98361774
33	double-strand break repair via homologous recombination (GO:0000724)	2.97929660
34	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97344959
35	histone exchange (GO:0043486)	2.95615268
36	DNA ligation (GO:0006266)	2.94829345
37	positive regulation of catecholamine secretion (GO:0033605)	2.94559705
38	epithelial cilium movement (GO:0003351)	2.92591501
39	quinone biosynthetic process (GO:1901663)	2.91716064
40	purine nucleotide salvage (GO:0032261)	2.86971803
41	inositol phosphate catabolic process (GO:0071545)	2.85909500
42	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.85361911
43	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.84912280
44	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.80950245
45	behavioral response to nicotine (GO:0035095)	2.80628347
46	telomere maintenance via semi-conservative replication (GO:0032201)	2.80613866
47	purine deoxyribonucleotide metabolic process (GO:0009151)	2.80270127
48	platelet dense granule organization (GO:0060155)	2.80170696
49	protein polyglutamylation (GO:0018095)	2.78332462
50	mitochondrial DNA replication (GO:0006264)	2.77057404
51	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.76657821
52	purine-containing compound salvage (GO:0043101)	2.76404464
53	deoxyribose phosphate catabolic process (GO:0046386)	2.76183921
54	chromatin remodeling at centromere (GO:0031055)	2.75364705
55	protein complex biogenesis (GO:0070271)	2.74719849
56	protein deneddylation (GO:0000338)	2.73034636
57	L-methionine salvage (GO:0071267)	2.72023791
58	L-methionine biosynthetic process (GO:0071265)	2.72023791
59	amino acid salvage (GO:0043102)	2.72023791
60	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.71287579
61	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.71012916
62	ADP metabolic process (GO:0046031)	2.70460692
63	telomere maintenance via recombination (GO:0000722)	2.69945605
64	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.68438317
65	chaperone-mediated protein transport (GO:0072321)	2.67878162
66	centriole assembly (GO:0098534)	2.66051750
67	estrogen biosynthetic process (GO:0006703)	2.65966061
68	CENP-A containing nucleosome assembly (GO:0034080)	2.65045015
69	regulation of helicase activity (GO:0051095)	2.64131933
70	adenosine metabolic process (GO:0046085)	2.59664482
71	proteasome assembly (GO:0043248)	2.58917202
72	rRNA catabolic process (GO:0016075)	2.58492041
73	mitotic recombination (GO:0006312)	2.57244312
74	GTP biosynthetic process (GO:0006183)	2.55673539
75	relaxation of smooth muscle (GO:0044557)	2.55420261
76	sperm-egg recognition (GO:0035036)	2.54520249
77	multicellular organism reproduction (GO:0032504)	2.54141041
78	seminiferous tubule development (GO:0072520)	2.53130742
79	negative regulation by host of viral transcription (GO:0043922)	2.53017871
80	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.52708245
81	branched-chain amino acid catabolic process (GO:0009083)	2.51484005
82	positive regulation of antigen processing and presentation (GO:0002579)	2.49472984
83	mannosylation (GO:0097502)	2.47350814
84	kynurenine metabolic process (GO:0070189)	2.47144259
85	fucose catabolic process (GO:0019317)	2.45491648
86	L-fucose metabolic process (GO:0042354)	2.45491648
87	L-fucose catabolic process (GO:0042355)	2.45491648
88	DNA integration (GO:0015074)	2.45263914
89	response to nitrosative stress (GO:0051409)	2.44703919
90	mitochondrial respiratory chain complex assembly (GO:0033108)	2.43977881
91	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.42896414
92	telomere maintenance via telomere lengthening (GO:0010833)	2.42204036
93	GPI anchor metabolic process (GO:0006505)	2.41930682
94	intra-S DNA damage checkpoint (GO:0031573)	2.41928706
95	binding of sperm to zona pellucida (GO:0007339)	2.41590604
96	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.39664855
97	inositol phosphate dephosphorylation (GO:0046855)	2.39664855
98	DNA replication initiation (GO:0006270)	2.38361452
99	DNA methylation involved in gamete generation (GO:0043046)	2.37439297
100	aromatic amino acid family catabolic process (GO:0009074)	2.36505319

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.78272066
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.65919185
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.09273499
4	VDR_22108803_ChIP-Seq_LS180_Human	3.66291415
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.55335150
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.85873552
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.77019874
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.70698666
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.36194676
10	FUS_26573619_Chip-Seq_HEK293_Human	2.33811303
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.33161265
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.29702108
13	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.29375453
14	EWS_26573619_Chip-Seq_HEK293_Human	2.25714934
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.17712355
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.13857204
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.08374683
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.08127426
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.05509773
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.04479641
21	E2F7_22180533_ChIP-Seq_HELA_Human	1.99624396
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.94557620
23	P300_19829295_ChIP-Seq_ESCs_Human	1.90441870
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.85910601
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.84814312
26	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.83920358
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.83109183
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.83109183
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.78251256
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.76308581
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.75331517
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.72203480
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.61714181
34	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.52930637
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.50062884
36	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.46119226
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44354382
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42768169
39	ELK1_19687146_ChIP-ChIP_HELA_Human	1.42406002
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39037240
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39037240
42	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.38543841
43	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.38323162
44	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.36917998
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36766233
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35603601
47	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33853990
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32607241
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32607241
50	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.26465570
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.25136855
52	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.22543994
53	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.22323967
54	AR_25329375_ChIP-Seq_VCAP_Human	1.21038472
55	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.20679990
56	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.19676429
57	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.17975936
58	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.16080230
59	SCL_19346495_ChIP-Seq_HPC-7_Human	1.15939276
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15440407
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15440407
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15226053
63	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15193159
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13463871
65	AR_20517297_ChIP-Seq_VCAP_Human	1.13299165
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11637461
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10234548
68	NCOR_22424771_ChIP-Seq_293T_Human	1.07097268
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06747551
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.06615307
71	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06455336
72	GATA3_26560356_Chip-Seq_TH2_Human	1.06200374
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05500642
74	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.02411262
75	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.01053448
76	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00162061
77	MYB_26560356_Chip-Seq_TH2_Human	1.00078099
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99905318
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99681683
80	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.99153109
81	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.97787025
82	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.97285349
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96322841
84	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.95737451
85	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95293330
86	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93790016
87	STAT3_23295773_ChIP-Seq_U87_Human	0.92727059
88	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.92715800
89	CBP_21632823_ChIP-Seq_H3396_Human	0.91450247
90	TCF4_23295773_ChIP-Seq_U87_Human	0.90957683
91	CIITA_25753668_ChIP-Seq_RAJI_Human	0.90911183
92	ERG_20517297_ChIP-Seq_VCAP_Human	0.90521948
93	CDX2_22108803_ChIP-Seq_LS180_Human	0.89629431
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.88206112
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88009825
96	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.87335983
97	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.87296214
98	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.86625257
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.84750816
100	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.84128038

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.30362459
2	MP0009697_abnormal_copulation	3.42666200
3	MP0005410_abnormal_fertilization	2.97048658
4	MP0008058_abnormal_DNA_repair	2.95130771
5	MP0006292_abnormal_olfactory_placode	2.75421942
6	MP0002160_abnormal_reproductive_system	2.63829152
7	MP0002837_dystrophic_cardiac_calcinosis	2.52328805
8	MP0002132_abnormal_respiratory_system	2.27556037
9	MP0010094_abnormal_chromosome_stability	2.20863540
10	MP0002102_abnormal_ear_morphology	2.20125054
11	MP0001835_abnormal_antigen_presentation	2.18114463
12	MP0005084_abnormal_gallbladder_morpholo	2.14907332
13	MP0010368_abnormal_lymphatic_system	2.04062658
14	MP0001529_abnormal_vocalization	2.00975144
15	MP0001968_abnormal_touch/_nociception	2.00591358
16	MP0003718_maternal_effect	1.98285288
17	MP0003183_abnormal_peptide_metabolism	1.94673604
18	MP0010386_abnormal_urinary_bladder	1.89879502
19	MP0006036_abnormal_mitochondrial_physio	1.89168984
20	MP0000465_gastrointestinal_hemorrhage	1.83079916
21	MP0005646_abnormal_pituitary_gland	1.80839304
22	MP0001764_abnormal_homeostasis	1.76483198
23	MP0008004_abnormal_stomach_pH	1.75168375
24	MP0005645_abnormal_hypothalamus_physiol	1.74178194
25	MP0000569_abnormal_digit_pigmentation	1.71556905
26	MP0002736_abnormal_nociception_after	1.68583822
27	MP0003303_peritoneal_inflammation	1.63648544
28	MP0008877_abnormal_DNA_methylation	1.59058487
29	MP0001929_abnormal_gametogenesis	1.55266692
30	MP0003880_abnormal_central_pattern	1.54509228
31	MP0001905_abnormal_dopamine_level	1.53511983
32	MP0005367_renal/urinary_system_phenotyp	1.51537272
33	MP0000516_abnormal_urinary_system	1.51537272
34	MP0003693_abnormal_embryo_hatching	1.47869080
35	MP0003315_abnormal_perineum_morphology	1.44576209
36	MP0000372_irregular_coat_pigmentation	1.42551901
37	MP0006276_abnormal_autonomic_nervous	1.42006290
38	MP0005389_reproductive_system_phenotype	1.40643798
39	MP0002138_abnormal_hepatobiliary_system	1.38501589
40	MP0008789_abnormal_olfactory_epithelium	1.36448826
41	MP0006035_abnormal_mitochondrial_morpho	1.34273045
42	MP0008872_abnormal_physiological_respon	1.33834081
43	MP0003136_yellow_coat_color	1.30933448
44	MP0005551_abnormal_eye_electrophysiolog	1.28436881
45	MP0003698_abnormal_male_reproductive	1.27464147
46	MP0006072_abnormal_retinal_apoptosis	1.23915242
47	MP0004147_increased_porphyrin_level	1.23865453
48	MP0005075_abnormal_melanosome_morpholog	1.20477779
49	MP0001545_abnormal_hematopoietic_system	1.19571299
50	MP0005397_hematopoietic_system_phenotyp	1.19571299
51	MP0002234_abnormal_pharynx_morphology	1.17657323
52	MP0001664_abnormal_digestion	1.14810815
53	MP0008007_abnormal_cellular_replicative	1.10814706
54	MP0003646_muscle_fatigue	1.09343490
55	MP0002148_abnormal_hypersensitivity_rea	1.08305941
56	MP0009785_altered_susceptibility_to	1.05082838
57	MP0001984_abnormal_olfaction	1.03062036
58	MP0005174_abnormal_tail_pigmentation	0.99247835
59	MP0005253_abnormal_eye_physiology	0.95921180
60	MP0005499_abnormal_olfactory_system	0.95502668
61	MP0005394_taste/olfaction_phenotype	0.95502668
62	MP0003111_abnormal_nucleus_morphology	0.95450970
63	MP0005083_abnormal_biliary_tract	0.94575033
64	MP0004084_abnormal_cardiac_muscle	0.92352530
65	MP0001145_abnormal_male_reproductive	0.91207417
66	MP0000653_abnormal_sex_gland	0.90503837
67	MP0000230_abnormal_systemic_arterial	0.86976028
68	MP0003567_abnormal_fetal_cardiomyocyte	0.85892227
69	MP0003786_premature_aging	0.84962545
70	MP0000538_abnormal_urinary_bladder	0.84884763
71	MP0002210_abnormal_sex_determination	0.84271516
72	MP0005220_abnormal_exocrine_pancreas	0.82855681
73	MP0000681_abnormal_thyroid_gland	0.81296802
74	MP0000015_abnormal_ear_pigmentation	0.80925984
75	MP0004215_abnormal_myocardial_fiber	0.78583947
76	MP0000631_abnormal_neuroendocrine_gland	0.77590158
77	MP0005395_other_phenotype	0.77045980
78	MP0008995_early_reproductive_senescence	0.76723335
79	MP0002751_abnormal_autonomic_nervous	0.76387347
80	MP0003077_abnormal_cell_cycle	0.71091604
81	MP0009764_decreased_sensitivity_to	0.71063805
82	MP0005647_abnormal_sex_gland	0.70120550
83	MP0001486_abnormal_startle_reflex	0.69685427
84	MP0009278_abnormal_bone_marrow	0.68038051
85	MP0001293_anophthalmia	0.67942747
86	MP0005464_abnormal_platelet_physiology	0.66722610
87	MP0000427_abnormal_hair_cycle	0.66511557
88	MP0003186_abnormal_redox_activity	0.66245582
89	MP0004145_abnormal_muscle_electrophysio	0.64978871
90	MP0001501_abnormal_sleep_pattern	0.64810451
91	MP0005319_abnormal_enzyme/_coenzyme	0.64388124
92	MP0002090_abnormal_vision	0.62848194
93	MP0002095_abnormal_skin_pigmentation	0.62155551
94	MP0008875_abnormal_xenobiotic_pharmacok	0.60993401
95	MP0002735_abnormal_chemical_nociception	0.60227895
96	MP0002733_abnormal_thermal_nociception	0.59722336
97	MP0004142_abnormal_muscle_tone	0.57808039
98	MP0004085_abnormal_heartbeat	0.57786398
99	MP0002127_abnormal_cardiovascular_syste	0.57054475
100	MP0002019_abnormal_tumor_incidence	0.56788646

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	3.69834393
2	Reduced antithrombin III activity (HP:0001976)	3.59216455
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.27747543
4	Absent/shortened dynein arms (HP:0200106)	3.27747543
5	Acute lymphatic leukemia (HP:0006721)	3.16507016
6	3-Methylglutaconic aciduria (HP:0003535)	3.14116561
7	Pancreatic cysts (HP:0001737)	3.06350998
8	Pancreatic fibrosis (HP:0100732)	3.01544464
9	True hermaphroditism (HP:0010459)	2.87244948
10	Abnormal protein glycosylation (HP:0012346)	2.83373666
11	Abnormal glycosylation (HP:0012345)	2.83373666
12	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.83373666
13	Abnormal protein N-linked glycosylation (HP:0012347)	2.83373666
14	Abnormality of macular pigmentation (HP:0008002)	2.80713326
15	Lipid accumulation in hepatocytes (HP:0006561)	2.78348121
16	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.75521769
17	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.75521769
18	Abolished electroretinogram (ERG) (HP:0000550)	2.74941231
19	Abnormality of the prostate (HP:0008775)	2.73342617
20	Increased intramyocellular lipid droplets (HP:0012240)	2.57722212
21	Cerebellar dysplasia (HP:0007033)	2.57174153
22	Abnormal mitochondria in muscle tissue (HP:0008316)	2.55441620
23	Increased muscle lipid content (HP:0009058)	2.54712423
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.54045044
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.53601040
26	Acute necrotizing encephalopathy (HP:0006965)	2.51155580
27	Abnormal biliary tract physiology (HP:0012439)	2.50420195
28	Bile duct proliferation (HP:0001408)	2.50420195
29	Tubulointerstitial nephritis (HP:0001970)	2.45355621
30	Mitochondrial inheritance (HP:0001427)	2.44848287
31	Type I transferrin isoform profile (HP:0003642)	2.44737984
32	Abnormality of B cell number (HP:0010975)	2.38112029
33	B lymphocytopenia (HP:0010976)	2.34380593
34	Abnormal respiratory motile cilium morphology (HP:0005938)	2.32266931
35	Abnormal respiratory epithelium morphology (HP:0012253)	2.32266931
36	Abnormal ciliary motility (HP:0012262)	2.32057026
37	Increased hepatocellular lipid droplets (HP:0006565)	2.30711444
38	Medial flaring of the eyebrow (HP:0010747)	2.29405077
39	Abnormal rod and cone electroretinograms (HP:0008323)	2.27609256
40	Increased CSF lactate (HP:0002490)	2.24860228
41	Central scotoma (HP:0000603)	2.23575532
42	Hepatocellular necrosis (HP:0001404)	2.21018436
43	Congenital stationary night blindness (HP:0007642)	2.20002356
44	Hepatic necrosis (HP:0002605)	2.18835586
45	Type II lissencephaly (HP:0007260)	2.18690094
46	Progressive macrocephaly (HP:0004481)	2.18269689
47	Abnormal respiratory motile cilium physiology (HP:0012261)	2.17826664
48	Acute encephalopathy (HP:0006846)	2.16022579
49	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.15731890
50	Renal cortical cysts (HP:0000803)	2.15471284
51	Facial hemangioma (HP:0000329)	2.14335260
52	Hypoplasia of the uterus (HP:0000013)	2.13724635
53	Nephronophthisis (HP:0000090)	2.12309904
54	Abnormality of male internal genitalia (HP:0000022)	2.11672512
55	Abnormality of midbrain morphology (HP:0002418)	2.11079879
56	Molar tooth sign on MRI (HP:0002419)	2.11079879
57	Retinal dysplasia (HP:0007973)	2.10688964
58	Median cleft lip (HP:0000161)	2.07049390
59	Poor head control (HP:0002421)	2.05791272
60	Dyschromatopsia (HP:0007641)	2.03710368
61	Type 2 muscle fiber atrophy (HP:0003554)	2.00678720
62	Sloping forehead (HP:0000340)	1.99754187
63	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.99710833
64	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.99225174
65	Decreased central vision (HP:0007663)	1.98602692
66	Exertional dyspnea (HP:0002875)	1.98338795
67	Amyotrophic lateral sclerosis (HP:0007354)	1.97304690
68	Clubbing of toes (HP:0100760)	1.96442883
69	Ketosis (HP:0001946)	1.96014241
70	Hyperglycinemia (HP:0002154)	1.95827107
71	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.95335813
72	Dicarboxylic aciduria (HP:0003215)	1.95335813
73	Eosinophilia (HP:0001880)	1.94964681
74	Abnormality of the ileum (HP:0001549)	1.94907645
75	Hypothermia (HP:0002045)	1.93859628
76	Abnormality of the renal medulla (HP:0100957)	1.93308783
77	Abnormality of DNA repair (HP:0003254)	1.92681718
78	Postaxial foot polydactyly (HP:0001830)	1.92439848
79	Renal Fanconi syndrome (HP:0001994)	1.92414228
80	Male pseudohermaphroditism (HP:0000037)	1.91254811
81	Myoglobinuria (HP:0002913)	1.91057550
82	Chronic hepatic failure (HP:0100626)	1.90073222
83	Meckel diverticulum (HP:0002245)	1.89525159
84	Abnormality of the renal cortex (HP:0011035)	1.88838186
85	Pancytopenia (HP:0001876)	1.88716669
86	Abnormality of lateral ventricle (HP:0030047)	1.88657895
87	Capillary hemangiomas (HP:0005306)	1.88336430
88	Occipital encephalocele (HP:0002085)	1.87810256
89	Colon cancer (HP:0003003)	1.86947227
90	Abnormality of chromosome stability (HP:0003220)	1.86513271
91	Volvulus (HP:0002580)	1.86202560
92	Thoracic kyphosis (HP:0002942)	1.83737321
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.83274448
94	Abnormality of urine glucose concentration (HP:0011016)	1.81653000
95	Glycosuria (HP:0003076)	1.81653000
96	Cystic liver disease (HP:0006706)	1.79345568
97	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79203265
98	Granulocytopenia (HP:0001913)	1.76548619
99	Chromsome breakage (HP:0040012)	1.75577888
100	Lactic acidosis (HP:0003128)	1.73989967

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.34900398
2	MAP4K2	4.03151225
3	TAOK3	2.87487163
4	ZAK	2.83016953
5	FRK	2.77715634
6	NUAK1	2.67526941
7	BMPR1B	2.54628274
8	CDK19	2.51756591
9	TLK1	2.22732889
10	FLT3	2.15473608
11	TESK2	2.11183999
12	MARK3	2.09960808
13	PLK4	2.09281396
14	BCKDK	2.01274551
15	LATS1	1.85097532
16	ADRBK2	1.73952650
17	EIF2AK3	1.71582627
18	NEK2	1.70924249
19	TXK	1.69122211
20	NEK1	1.52211588
21	PBK	1.38783649
22	TIE1	1.38482354
23	KIT	1.35154535
24	KDR	1.31467267
25	CSNK1G3	1.31101235
26	CDC7	1.27837896
27	WEE1	1.25281095
28	RPS6KA4	1.24094466
29	VRK1	1.23757377
30	WNK4	1.18796692
31	MAPK13	1.18246155
32	RPS6KA5	1.12747553
33	TRIM28	1.12558993
34	CSNK1A1L	1.11627571
35	MKNK1	1.07913793
36	VRK2	1.04953101
37	CDK3	1.04333776
38	ERBB3	1.01397041
39	CDK8	1.00730753
40	BMPR2	1.00398711
41	CSNK1G1	0.98895885
42	PIK3CG	0.95646218
43	OBSCN	0.94069884
44	PRKCQ	0.93547541
45	TGFBR1	0.93451252
46	GRK1	0.91418088
47	CSNK1G2	0.91085493
48	CCNB1	0.89738107
49	CSF1R	0.87115051
50	SRPK1	0.86544836
51	ATR	0.85776544
52	PLK1	0.85337386
53	BUB1	0.83895557
54	TEC	0.83334352
55	MAP3K13	0.80459215
56	INSRR	0.79058123
57	OXSR1	0.77465801
58	PLK3	0.73754851
59	TNIK	0.71866072
60	FES	0.71374226
61	SCYL2	0.71182296
62	ATM	0.67679016
63	MKNK2	0.66153959
64	DYRK2	0.65564720
65	WNK3	0.65073658
66	MAP2K6	0.62579024
67	PTK2B	0.61131182
68	MAP2K7	0.60640048
69	STK16	0.59772052
70	MST4	0.58239725
71	GRK7	0.57766252
72	ACVR1B	0.56243193
73	MAP4K1	0.55894382
74	TNK2	0.55294267
75	PLK2	0.52115048
76	SYK	0.47939891
77	CSNK1A1	0.47641081
78	BTK	0.47248166
79	DYRK3	0.43547858
80	MYLK	0.42667750
81	MAPKAPK5	0.38415743
82	ITK	0.35819809
83	CDK7	0.35609349
84	AURKB	0.35386375
85	STK39	0.34478194
86	NME2	0.33188461
87	EIF2AK2	0.33128093
88	STK3	0.33109000
89	PRKD3	0.33031848
90	STK38L	0.32779026
91	MAP3K12	0.32731410
92	IKBKB	0.32681792
93	CASK	0.31956430
94	DAPK1	0.31336452
95	IGF1R	0.30894931
96	BRSK2	0.30568215
97	PRKG1	0.29964838
98	GRK5	0.29336875
99	MAP2K4	0.27821112
100	PRKCE	0.27774337

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.27059931
2	Homologous recombination_Homo sapiens_hsa03440	2.78306567
3	Protein export_Homo sapiens_hsa03060	2.63833358
4	DNA replication_Homo sapiens_hsa03030	2.50069793
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.49532477
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.36656491
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.35653962
8	Allograft rejection_Homo sapiens_hsa05330	2.31991664
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.29063777
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.20931883
11	Base excision repair_Homo sapiens_hsa03410	2.15347401
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.12550535
13	RNA polymerase_Homo sapiens_hsa03020	2.08553750
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.02695461
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.96806004
16	Proteasome_Homo sapiens_hsa03050	1.94298243
17	RNA degradation_Homo sapiens_hsa03018	1.91301392
18	Mismatch repair_Homo sapiens_hsa03430	1.88997397
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.87767018
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.85679591
21	Phototransduction_Homo sapiens_hsa04744	1.78099717
22	Propanoate metabolism_Homo sapiens_hsa00640	1.77376595
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.71705156
24	Butanoate metabolism_Homo sapiens_hsa00650	1.62870315
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.62003526
26	Fatty acid elongation_Homo sapiens_hsa00062	1.61280364
27	Olfactory transduction_Homo sapiens_hsa04740	1.54542759
28	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.51082861
29	Peroxisome_Homo sapiens_hsa04146	1.45554737
30	Parkinsons disease_Homo sapiens_hsa05012	1.43150808
31	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.41234317
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.38534245
33	Basal transcription factors_Homo sapiens_hsa03022	1.37245492
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.37043590
35	Antigen processing and presentation_Homo sapiens_hsa04612	1.31495656
36	Purine metabolism_Homo sapiens_hsa00230	1.30978362
37	Oxidative phosphorylation_Homo sapiens_hsa00190	1.30145619
38	Rheumatoid arthritis_Homo sapiens_hsa05323	1.27606228
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.26405267
40	Selenocompound metabolism_Homo sapiens_hsa00450	1.23644702
41	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.12641319
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.11001014
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.08713484
44	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.01690200
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01098423
46	Taste transduction_Homo sapiens_hsa04742	0.97928666
47	One carbon pool by folate_Homo sapiens_hsa00670	0.94547986
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92126275
49	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.91304140
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89313290
51	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.88554097
52	Fatty acid degradation_Homo sapiens_hsa00071	0.85863131
53	RNA transport_Homo sapiens_hsa03013	0.85515173
54	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.80444082
55	Regulation of autophagy_Homo sapiens_hsa04140	0.78160643
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.77937831
57	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.76928309
58	Linoleic acid metabolism_Homo sapiens_hsa00591	0.76279144
59	Leishmaniasis_Homo sapiens_hsa05140	0.75735296
60	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.74249873
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73712405
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70964452
63	Spliceosome_Homo sapiens_hsa03040	0.70718673
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.70586990
65	Salivary secretion_Homo sapiens_hsa04970	0.70261363
66	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.68164518
67	Metabolic pathways_Homo sapiens_hsa01100	0.67733602
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66873207
69	Glutathione metabolism_Homo sapiens_hsa00480	0.59594491
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58520046
71	Viral myocarditis_Homo sapiens_hsa05416	0.56960232
72	Herpes simplex infection_Homo sapiens_hsa05168	0.56908755
73	Huntingtons disease_Homo sapiens_hsa05016	0.56669584
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54487421
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53390500
76	Primary immunodeficiency_Homo sapiens_hsa05340	0.53362490
77	Alzheimers disease_Homo sapiens_hsa05010	0.50556146
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50394235
79	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.48969307
80	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45759315
81	Oocyte meiosis_Homo sapiens_hsa04114	0.43665116
82	Phagosome_Homo sapiens_hsa04145	0.43063078
83	Renin secretion_Homo sapiens_hsa04924	0.42940475
84	Folate biosynthesis_Homo sapiens_hsa00790	0.42218080
85	Retinol metabolism_Homo sapiens_hsa00830	0.40795499
86	Alcoholism_Homo sapiens_hsa05034	0.40013190
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.39508879
88	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38859124
89	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.38123119
90	Legionellosis_Homo sapiens_hsa05134	0.37950662
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.37459458
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.36674666
93	African trypanosomiasis_Homo sapiens_hsa05143	0.36364040
94	Cell cycle_Homo sapiens_hsa04110	0.36260138
95	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.35474401
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.35379816
97	Ribosome_Homo sapiens_hsa03010	0.33561512
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32417158
99	p53 signaling pathway_Homo sapiens_hsa04115	0.28505070
100	Steroid biosynthesis_Homo sapiens_hsa00100	0.27945595

ULK4P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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