ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	aggressive behavior (GO:0002118)	5.57315366
2	base-excision repair, AP site formation (GO:0006285)	4.56582271
3	hyperosmotic salinity response (GO:0042538)	4.46324109
4	purine deoxyribonucleotide catabolic process (GO:0009155)	4.34064395
5	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.16658705
6	ubiquinone biosynthetic process (GO:0006744)	4.11021344
7	deoxyribonucleotide catabolic process (GO:0009264)	3.98898982
8	ubiquinone metabolic process (GO:0006743)	3.97110398
9	DNA double-strand break processing (GO:0000729)	3.81470858
10	deoxyribose phosphate catabolic process (GO:0046386)	3.67185634
11	centriole replication (GO:0007099)	3.56614193
12	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.55587280
13	grooming behavior (GO:0007625)	3.54256178
14	spermatid development (GO:0007286)	3.53462919
15	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.44405253
16	piRNA metabolic process (GO:0034587)	3.44223042
17	pyrimidine nucleotide catabolic process (GO:0006244)	3.35789383
18	fusion of sperm to egg plasma membrane (GO:0007342)	3.31503335
19	quinone biosynthetic process (GO:1901663)	3.27541788
20	sperm motility (GO:0030317)	3.26449701
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.24668460
22	NADH dehydrogenase complex assembly (GO:0010257)	3.24668460
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.24668460
24	aspartate family amino acid catabolic process (GO:0009068)	3.21270079
25	protein complex biogenesis (GO:0070271)	3.19681366
26	immunoglobulin mediated immune response (GO:0016064)	3.18511262
27	telomere maintenance via semi-conservative replication (GO:0032201)	3.17381903
28	mismatch repair (GO:0006298)	3.15915191
29	pentose metabolic process (GO:0019321)	3.15872508
30	regulation of female receptivity (GO:0045924)	3.13359310
31	mitochondrial respiratory chain complex assembly (GO:0033108)	3.10917717
32	regulation of penile erection (GO:0060405)	3.08616929
33	positive regulation of antigen processing and presentation (GO:0002579)	3.07305478
34	estrogen biosynthetic process (GO:0006703)	3.06712158
35	iron-sulfur cluster assembly (GO:0016226)	3.05857663
36	metallo-sulfur cluster assembly (GO:0031163)	3.05857663
37	tryptophan catabolic process (GO:0006569)	3.04137926
38	indole-containing compound catabolic process (GO:0042436)	3.04137926
39	indolalkylamine catabolic process (GO:0046218)	3.04137926
40	DNA ligation (GO:0006266)	2.98192082
41	mitochondrial RNA metabolic process (GO:0000959)	2.96485355
42	centriole assembly (GO:0098534)	2.95972450
43	purine deoxyribonucleotide metabolic process (GO:0009151)	2.95590755
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.95016373
45	negative regulation of B cell apoptotic process (GO:0002903)	2.94959255
46	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.93747858
47	tryptophan metabolic process (GO:0006568)	2.92152431
48	female mating behavior (GO:0060180)	2.91787308
49	2-deoxyribonucleotide metabolic process (GO:0009394)	2.90189649
50	sperm-egg recognition (GO:0035036)	2.89836515
51	relaxation of smooth muscle (GO:0044557)	2.88806850
52	B cell mediated immunity (GO:0019724)	2.88549877
53	DNA strand elongation involved in DNA replication (GO:0006271)	2.87986277
54	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.86848448
55	binding of sperm to zona pellucida (GO:0007339)	2.85890368
56	cell wall macromolecule catabolic process (GO:0016998)	2.85563227
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.85135222
58	telomere maintenance via recombination (GO:0000722)	2.84924372
59	response to pheromone (GO:0019236)	2.84625735
60	regulation of antigen processing and presentation (GO:0002577)	2.83772385
61	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.83542134
62	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.83117846
63	seminiferous tubule development (GO:0072520)	2.82497210
64	ribosomal small subunit assembly (GO:0000028)	2.80563493
65	base-excision repair (GO:0006284)	2.76060558
66	histone exchange (GO:0043486)	2.75679638
67	DNA replication initiation (GO:0006270)	2.75348811
68	positive regulation of catecholamine secretion (GO:0033605)	2.74974213
69	plasma membrane fusion (GO:0045026)	2.74313539
70	mitotic recombination (GO:0006312)	2.73232079
71	DNA strand elongation (GO:0022616)	2.71998892
72	short-chain fatty acid metabolic process (GO:0046459)	2.69923174
73	multicellular organism reproduction (GO:0032504)	2.68795521
74	DNA deamination (GO:0045006)	2.68181727
75	daunorubicin metabolic process (GO:0044597)	2.67973872
76	polyketide metabolic process (GO:0030638)	2.67973872
77	doxorubicin metabolic process (GO:0044598)	2.67973872
78	quinone metabolic process (GO:1901661)	2.66709697
79	DNA methylation involved in gamete generation (GO:0043046)	2.66651265
80	protein deneddylation (GO:0000338)	2.66584175
81	deoxyribonucleotide metabolic process (GO:0009262)	2.66256981
82	negative regulation of cell cycle G2/M phase transition (GO:1902750)	2.65701359
83	positive regulation of interleukin-17 production (GO:0032740)	2.63226837
84	deoxyribose phosphate metabolic process (GO:0019692)	2.62973473
85	male meiosis (GO:0007140)	2.62720286
86	chaperone-mediated protein transport (GO:0072321)	2.59186482
87	telomere maintenance via telomere lengthening (GO:0010833)	2.58104372
88	purine nucleobase biosynthetic process (GO:0009113)	2.57318684
89	acrosome reaction (GO:0007340)	2.56460940
90	DNA integration (GO:0015074)	2.54653637
91	indolalkylamine metabolic process (GO:0006586)	2.54279481
92	cell wall macromolecule metabolic process (GO:0044036)	2.53379332
93	DNA catabolic process, exonucleolytic (GO:0000738)	2.53333474
94	cilium or flagellum-dependent cell motility (GO:0001539)	2.52903685
95	recombinational repair (GO:0000725)	2.52684077
96	potassium ion export (GO:0071435)	2.51935671
97	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.50923353
98	nucleotide salvage (GO:0043173)	2.50016043
99	GPI anchor biosynthetic process (GO:0006506)	2.49860955
100	chromatin remodeling at centromere (GO:0031055)	2.49630151

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.87941294
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.83616105
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.12911896
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.73590284
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.59139317
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97715632
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.84860192
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.60033458
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.58188434
10	VDR_22108803_ChIP-Seq_LS180_Human	2.56097660
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.44563325
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.40295252
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.27279704
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.24820487
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.15545316
16	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.14157204
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.13383020
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.00973518
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.99507790
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.98170535
21	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.96185753
22	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.93442272
23	FUS_26573619_Chip-Seq_HEK293_Human	1.87085310
24	SCL_19346495_ChIP-Seq_HPC-7_Human	1.86397572
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.76407241
26	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.73218379
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.72443416
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.72007726
29	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.64302969
30	CIITA_25753668_ChIP-Seq_RAJI_Human	1.60131460
31	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.59567272
32	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.59491014
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.51512665
34	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.50364905
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.48909648
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.44899143
37	EWS_26573619_Chip-Seq_HEK293_Human	1.44636916
38	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.40799893
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39359178
40	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.38953689
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38825015
42	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.37737477
43	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.37234218
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.36736887
45	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.36046663
46	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.32264681
47	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.30848867
48	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.27298990
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24419095
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.24419095
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.24331301
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.24032860
53	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.23383998
54	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22930612
55	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.22783580
56	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22600966
57	TAF15_26573619_Chip-Seq_HEK293_Human	1.20595552
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.20069806
59	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.18350141
60	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.17375973
61	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.16606164
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.15997855
63	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.14507293
64	TTF2_22483619_ChIP-Seq_HELA_Human	1.13934942
65	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.12545174
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10620333
67	ER_23166858_ChIP-Seq_MCF-7_Human	1.09691911
68	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.09419081
69	SPI1_23547873_ChIP-Seq_NB4_Human	1.08730513
70	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.07232327
71	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.06650921
72	BCL6_27268052_Chip-Seq_Bcells_Human	1.06547821
73	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.05338367
74	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.04464118
75	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04452490
76	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.04193016
77	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.03425487
78	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03134690
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03101743
80	AR_20517297_ChIP-Seq_VCAP_Human	1.02055846
81	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.01669705
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01453073
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.00832320
84	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00641278
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00641278
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99757063
87	RAC3_21632823_ChIP-Seq_H3396_Human	0.99727293
88	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99605215
89	P300_19829295_ChIP-Seq_ESCs_Human	0.99299625
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.99213345
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.99213345
92	DCP1A_22483619_ChIP-Seq_HELA_Human	0.98720476
93	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.97978363
94	NCOR_22424771_ChIP-Seq_293T_Human	0.97903658
95	GATA3_26560356_Chip-Seq_TH2_Human	0.96550951
96	MYB_26560356_Chip-Seq_TH2_Human	0.95540727
97	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.93423304
98	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.92427454
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.92427128
100	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.92200136

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.80993508
2	MP0003806_abnormal_nucleotide_metabolis	3.64424373
3	MP0008058_abnormal_DNA_repair	2.88443999
4	MP0005645_abnormal_hypothalamus_physiol	2.70106597
5	MP0000465_gastrointestinal_hemorrhage	2.69740872
6	MP0010094_abnormal_chromosome_stability	2.62939089
7	MP0008004_abnormal_stomach_pH	2.58430670
8	MP0003718_maternal_effect	2.54890600
9	MP0005646_abnormal_pituitary_gland	2.45162833
10	MP0002132_abnormal_respiratory_system	2.40864667
11	MP0006292_abnormal_olfactory_placode	2.35247359
12	MP0001835_abnormal_antigen_presentation	2.30644148
13	MP0001529_abnormal_vocalization	2.19461863
14	MP0009278_abnormal_bone_marrow	2.14284701
15	MP0009697_abnormal_copulation	2.11939902
16	MP0002160_abnormal_reproductive_system	2.02167097
17	MP0006036_abnormal_mitochondrial_physio	2.01829418
18	MP0003693_abnormal_embryo_hatching	1.98652257
19	MP0004147_increased_porphyrin_level	1.97383938
20	MP0001764_abnormal_homeostasis	1.95285043
21	MP0001545_abnormal_hematopoietic_system	1.95201682
22	MP0005397_hematopoietic_system_phenotyp	1.95201682
23	MP0006276_abnormal_autonomic_nervous	1.93548679
24	MP0000372_irregular_coat_pigmentation	1.83802237
25	MP0006035_abnormal_mitochondrial_morpho	1.80856433
26	MP0001929_abnormal_gametogenesis	1.73257530
27	MP0003880_abnormal_central_pattern	1.69494917
28	MP0003698_abnormal_male_reproductive	1.65581595
29	MP0010386_abnormal_urinary_bladder	1.65382631
30	MP0002822_catalepsy	1.63939998
31	MP0001905_abnormal_dopamine_level	1.61167746
32	MP0008007_abnormal_cellular_replicative	1.55513155
33	MP0003786_premature_aging	1.55139063
34	MP0008995_early_reproductive_senescence	1.51503898
35	MP0005084_abnormal_gallbladder_morpholo	1.51145262
36	MP0006072_abnormal_retinal_apoptosis	1.50967444
37	MP0003567_abnormal_fetal_cardiomyocyte	1.50371960
38	MP0001968_abnormal_touch/_nociception	1.45024899
39	MP0005075_abnormal_melanosome_morpholog	1.43316674
40	MP0010368_abnormal_lymphatic_system	1.38444132
41	MP0002653_abnormal_ependyma_morphology	1.33746286
42	MP0005464_abnormal_platelet_physiology	1.32555696
43	MP0005670_abnormal_white_adipose	1.32358174
44	MP0002736_abnormal_nociception_after	1.30295989
45	MP0003315_abnormal_perineum_morphology	1.30105901
46	MP0002735_abnormal_chemical_nociception	1.27435395
47	MP0005174_abnormal_tail_pigmentation	1.26973559
48	MP0002102_abnormal_ear_morphology	1.23572267
49	MP0008260_abnormal_autophagy	1.23113442
50	MP0005253_abnormal_eye_physiology	1.19904350
51	MP0002148_abnormal_hypersensitivity_rea	1.18684373
52	MP0002139_abnormal_hepatobiliary_system	1.14901261
53	MP0001984_abnormal_olfaction	1.07556511
54	MP0003077_abnormal_cell_cycle	1.07333964
55	MP0002210_abnormal_sex_determination	1.06611967
56	MP0001145_abnormal_male_reproductive	1.04343196
57	MP0005389_reproductive_system_phenotype	1.03561327
58	MP0000653_abnormal_sex_gland	1.03154672
59	MP0003111_abnormal_nucleus_morphology	1.02361635
60	MP0000358_abnormal_cell_content/	1.01371984
61	MP0002396_abnormal_hematopoietic_system	0.99981824
62	MP0005551_abnormal_eye_electrophysiolog	0.99656497
63	MP0005423_abnormal_somatic_nervous	0.98959362
64	MP0000681_abnormal_thyroid_gland	0.98071862
65	MP0005220_abnormal_exocrine_pancreas	0.98011006
66	MP0001664_abnormal_digestion	0.97432089
67	MP0000015_abnormal_ear_pigmentation	0.95324082
68	MP0002234_abnormal_pharynx_morphology	0.93717156
69	MP0000569_abnormal_digit_pigmentation	0.92616724
70	MP0003878_abnormal_ear_physiology	0.91432245
71	MP0005377_hearing/vestibular/ear_phenot	0.91432245
72	MP0004782_abnormal_surfactant_physiolog	0.86639495
73	MP0008875_abnormal_xenobiotic_pharmacok	0.86031240
74	MP0005647_abnormal_sex_gland	0.85783242
75	MP0008877_abnormal_DNA_methylation	0.85401796
76	MP0008932_abnormal_embryonic_tissue	0.83038937
77	MP0008789_abnormal_olfactory_epithelium	0.82950580
78	MP0004808_abnormal_hematopoietic_stem	0.82445911
79	MP0002095_abnormal_skin_pigmentation	0.81092617
80	MP0003186_abnormal_redox_activity	0.80698364
81	MP0009765_abnormal_xenobiotic_induced	0.80615726
82	MP0003303_peritoneal_inflammation	0.79952683
83	MP0000230_abnormal_systemic_arterial	0.76286545
84	MP0002161_abnormal_fertility/fecundity	0.76240871
85	MP0002090_abnormal_vision	0.75058568
86	MP0002019_abnormal_tumor_incidence	0.74807471
87	MP0003136_yellow_coat_color	0.74738022
88	MP0001501_abnormal_sleep_pattern	0.74467421
89	MP0001293_anophthalmia	0.71204997
90	MP0008872_abnormal_physiological_respon	0.70837216
91	MP0005025_abnormal_response_to	0.69184329
92	MP0008873_increased_physiological_sensi	0.69102563
93	MP0004142_abnormal_muscle_tone	0.68387482
94	MP0001119_abnormal_female_reproductive	0.68336425
95	MP0002009_preneoplasia	0.67186409
96	MP0004957_abnormal_blastocyst_morpholog	0.66915292
97	MP0005535_abnormal_body_temperature	0.66357164
98	MP0009785_altered_susceptibility_to	0.66173669
99	MP0009764_decreased_sensitivity_to	0.65183847
100	MP0003943_abnormal_hepatobiliary_system	0.64606706

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	3.45649301
2	Acute lymphatic leukemia (HP:0006721)	3.45514409
3	Colon cancer (HP:0003003)	3.45486081
4	Hepatocellular necrosis (HP:0001404)	3.25254463
5	Elevated erythrocyte sedimentation rate (HP:0003565)	3.22210726
6	Aplastic anemia (HP:0001915)	3.18173541
7	Increased intramyocellular lipid droplets (HP:0012240)	3.16491282
8	Mitochondrial inheritance (HP:0001427)	3.10635592
9	Increased muscle lipid content (HP:0009058)	3.03746816
10	Lipid accumulation in hepatocytes (HP:0006561)	2.99418670
11	Hepatic necrosis (HP:0002605)	2.97624728
12	Stomach cancer (HP:0012126)	2.88327338
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.87165440
14	Abnormal mitochondria in muscle tissue (HP:0008316)	2.86205915
15	Carpal bone hypoplasia (HP:0001498)	2.85862147
16	Meckel diverticulum (HP:0002245)	2.84024686
17	Abnormality of the ileum (HP:0001549)	2.80057112
18	Abnormality of the prostate (HP:0008775)	2.76165219
19	Hyperglycinemia (HP:0002154)	2.72914839
20	Increased hepatocellular lipid droplets (HP:0006565)	2.70953837
21	3-Methylglutaconic aciduria (HP:0003535)	2.69364049
22	Increased CSF lactate (HP:0002490)	2.65871049
23	Reduced antithrombin III activity (HP:0001976)	2.63277335
24	Acute necrotizing encephalopathy (HP:0006965)	2.61134328
25	Chromsome breakage (HP:0040012)	2.59974829
26	Thrombocytosis (HP:0001894)	2.59256942
27	Abnormality of the preputium (HP:0100587)	2.56416101
28	Medial flaring of the eyebrow (HP:0010747)	2.55822251
29	True hermaphroditism (HP:0010459)	2.51467266
30	Retinal dysplasia (HP:0007973)	2.48435436
31	Pancreatic cysts (HP:0001737)	2.45776716
32	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.44880722
33	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.44880722
34	Renal Fanconi syndrome (HP:0001994)	2.43414078
35	Pancreatic fibrosis (HP:0100732)	2.42806924
36	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.42022072
37	Dicarboxylic aciduria (HP:0003215)	2.42022072
38	Abnormality of male internal genitalia (HP:0000022)	2.39232123
39	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.36545849
40	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.36442841
41	Abnormality of chromosome stability (HP:0003220)	2.36043436
42	Abnormality of DNA repair (HP:0003254)	2.27849523
43	Increased serum lactate (HP:0002151)	2.27748918
44	Increased serum pyruvate (HP:0003542)	2.27002859
45	Attenuation of retinal blood vessels (HP:0007843)	2.24159263
46	Decreased central vision (HP:0007663)	2.23822254
47	Abnormality of macular pigmentation (HP:0008002)	2.23771284
48	Abolished electroretinogram (ERG) (HP:0000550)	2.22323036
49	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.22075871
50	Acute encephalopathy (HP:0006846)	2.21975517
51	Prostate neoplasm (HP:0100787)	2.21229113
52	Microvesicular hepatic steatosis (HP:0001414)	2.21054881
53	Pancytopenia (HP:0001876)	2.20498210
54	Abnormality of B cell number (HP:0010975)	2.20017742
55	Molar tooth sign on MRI (HP:0002419)	2.19742071
56	Abnormality of midbrain morphology (HP:0002418)	2.19742071
57	Absent/shortened dynein arms (HP:0200106)	2.19294719
58	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.19294719
59	Clubbing of toes (HP:0100760)	2.18571806
60	Cerebellar dysplasia (HP:0007033)	2.17793821
61	Lactic acidosis (HP:0003128)	2.15739851
62	Ragged-red muscle fibers (HP:0003200)	2.14556955
63	Type II lissencephaly (HP:0007260)	2.12893073
64	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.12721379
65	Abnormal protein N-linked glycosylation (HP:0012347)	2.12721379
66	Abnormal protein glycosylation (HP:0012346)	2.12721379
67	Abnormal glycosylation (HP:0012345)	2.12721379
68	Congenital primary aphakia (HP:0007707)	2.12714481
69	Exertional dyspnea (HP:0002875)	2.08829381
70	Brushfield spots (HP:0001088)	2.07570854
71	Abnormal ciliary motility (HP:0012262)	2.04372023
72	B lymphocytopenia (HP:0010976)	2.04024992
73	Triphalangeal thumb (HP:0001199)	2.03961893
74	Multiple enchondromatosis (HP:0005701)	2.03824923
75	Myelodysplasia (HP:0002863)	2.03536191
76	Abnormal respiratory epithelium morphology (HP:0012253)	2.01672390
77	Abnormal respiratory motile cilium morphology (HP:0005938)	2.01672390
78	Gait imbalance (HP:0002141)	2.00486353
79	Myoglobinuria (HP:0002913)	1.97354041
80	Panhypogammaglobulinemia (HP:0003139)	1.97218040
81	Progressive macrocephaly (HP:0004481)	1.96706044
82	Abnormal biliary tract physiology (HP:0012439)	1.95812227
83	Bile duct proliferation (HP:0001408)	1.95812227
84	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.94198561
85	Methylmalonic aciduria (HP:0012120)	1.93130533
86	Abnormality of glycolysis (HP:0004366)	1.92094701
87	Cerebral palsy (HP:0100021)	1.92089623
88	Sloping forehead (HP:0000340)	1.91935990
89	Median cleft lip (HP:0000161)	1.90769953
90	Exercise intolerance (HP:0003546)	1.90185579
91	Emotional lability (HP:0000712)	1.89954069
92	Optic disc pallor (HP:0000543)	1.89906210
93	Abnormal respiratory motile cilium physiology (HP:0012261)	1.89393065
94	Neurodegeneration (HP:0002180)	1.87371684
95	Delayed CNS myelination (HP:0002188)	1.86935803
96	Nephrogenic diabetes insipidus (HP:0009806)	1.85858441
97	Type I transferrin isoform profile (HP:0003642)	1.84780283
98	Premature ovarian failure (HP:0008209)	1.84720722
99	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.83226109
100	Bone marrow hypocellularity (HP:0005528)	1.82440161

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	3.42544777
2	ZAK	3.26653458
3	BMPR1B	2.93764508
4	FLT3	2.84393938
5	BCKDK	2.74732567
6	VRK2	2.69053696
7	PLK4	2.53085512
8	TESK2	2.51122792
9	KDR	2.46062335
10	NUAK1	2.44436129
11	NME2	2.32785439
12	CDC7	2.20672778
13	SRPK1	2.12679989
14	KIT	2.03098021
15	RPS6KA4	1.81714496
16	STK16	1.74921382
17	CDK19	1.72525625
18	TAOK3	1.71006321
19	ADRBK2	1.67189587
20	ERN1	1.63811790
21	TEC	1.61789544
22	MARK3	1.60858507
23	VRK1	1.53277456
24	MAP4K2	1.40215784
25	MKNK1	1.38585524
26	CDK8	1.38248748
27	TGFBR1	1.35810325
28	ERBB3	1.35013442
29	TIE1	1.33551776
30	WEE1	1.31508183
31	RPS6KA5	1.29175516
32	INSRR	1.27392223
33	CSNK1G3	1.23575263
34	FRK	1.18234112
35	EIF2AK3	1.16327618
36	LATS1	1.15999069
37	ATR	1.13276126
38	CDK7	1.08715034
39	TNK2	1.01918558
40	CSNK1A1L	0.99919186
41	CDK3	0.96673583
42	TLK1	0.96267848
43	TBK1	0.95819988
44	SCYL2	0.95731305
45	PLK1	0.94040604
46	NEK2	0.92347284
47	CSNK1G2	0.91741993
48	DYRK2	0.90779774
49	CSNK1G1	0.87602564
50	PLK2	0.87518469
51	CCNB1	0.86029266
52	PIM2	0.85330447
53	PTK2B	0.81760984
54	IKBKE	0.79654234
55	CSF1R	0.79496834
56	PBK	0.79342223
57	PRKCQ	0.75755820
58	FES	0.72274650
59	MAP3K5	0.72268811
60	BTK	0.70471427
61	MAP2K3	0.70468853
62	TRIM28	0.67373486
63	MAP3K13	0.65455064
64	TTK	0.65299895
65	ATM	0.65170882
66	ITK	0.64315310
67	CHEK2	0.63525547
68	PLK3	0.63158561
69	NEK1	0.60318642
70	DAPK1	0.58917885
71	MAPK15	0.57949064
72	MAPKAPK5	0.56607982
73	MAP2K7	0.56075205
74	BMPR2	0.55929942
75	SYK	0.52995766
76	MAP4K1	0.52119737
77	WNK3	0.50859616
78	AURKB	0.50513809
79	AKT2	0.50361833
80	MAPK13	0.50228636
81	GRK6	0.49288980
82	GRK1	0.47092197
83	CDK9	0.46725080
84	IKBKB	0.46609208
85	TAF1	0.45717433
86	LYN	0.45052739
87	PIM1	0.43283920
88	ACVR1B	0.42823093
89	PRKD3	0.41423277
90	GRK5	0.40962850
91	CSNK2A1	0.40108188
92	MST4	0.38995200
93	MAP2K6	0.38931689
94	DYRK3	0.38376041
95	MAP3K4	0.36821220
96	TXK	0.36186850
97	CSNK2A2	0.35318553
98	ADRBK1	0.33035269
99	EIF2AK2	0.32776495
100	PIK3CG	0.31953767

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.29610391
2	Asthma_Homo sapiens_hsa05310	3.19087322
3	Base excision repair_Homo sapiens_hsa03410	3.16211941
4	Homologous recombination_Homo sapiens_hsa03440	2.74202072
5	Allograft rejection_Homo sapiens_hsa05330	2.57168057
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.45863758
7	Mismatch repair_Homo sapiens_hsa03430	2.41317582
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.35461744
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.35041468
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.34790817
11	RNA polymerase_Homo sapiens_hsa03020	2.10052622
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.96633625
13	Type I diabetes mellitus_Homo sapiens_hsa04940	1.95641747
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.88598804
15	Protein export_Homo sapiens_hsa03060	1.85261294
16	Pyrimidine metabolism_Homo sapiens_hsa00240	1.80960082
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.77991252
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.75299223
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.65498302
20	Parkinsons disease_Homo sapiens_hsa05012	1.64540681
21	Fatty acid elongation_Homo sapiens_hsa00062	1.63029370
22	Propanoate metabolism_Homo sapiens_hsa00640	1.58883367
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.56670973
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.50782319
25	Butanoate metabolism_Homo sapiens_hsa00650	1.46854695
26	Spliceosome_Homo sapiens_hsa03040	1.46490379
27	Ribosome_Homo sapiens_hsa03010	1.45333871
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.34531266
29	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.33074327
30	Purine metabolism_Homo sapiens_hsa00230	1.32158296
31	Peroxisome_Homo sapiens_hsa04146	1.30891807
32	Regulation of autophagy_Homo sapiens_hsa04140	1.29949538
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.27639159
34	Antigen processing and presentation_Homo sapiens_hsa04612	1.27190385
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.27006828
36	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.25513105
37	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.22515498
38	One carbon pool by folate_Homo sapiens_hsa00670	1.22121923
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.21253050
40	Oxidative phosphorylation_Homo sapiens_hsa00190	1.18984637
41	RNA transport_Homo sapiens_hsa03013	1.11840165
42	Olfactory transduction_Homo sapiens_hsa04740	1.08262554
43	Basal transcription factors_Homo sapiens_hsa03022	1.08067215
44	Proteasome_Homo sapiens_hsa03050	1.07428597
45	RNA degradation_Homo sapiens_hsa03018	1.02781092
46	Glutathione metabolism_Homo sapiens_hsa00480	1.00085255
47	Fatty acid metabolism_Homo sapiens_hsa01212	0.98910394
48	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.97636142
49	Carbon metabolism_Homo sapiens_hsa01200	0.96242728
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96158140
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.96116280
52	Rheumatoid arthritis_Homo sapiens_hsa05323	0.93097501
53	Leishmaniasis_Homo sapiens_hsa05140	0.92541829
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.91911815
55	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.91001343
56	Huntingtons disease_Homo sapiens_hsa05016	0.90252133
57	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.88773252
58	Herpes simplex infection_Homo sapiens_hsa05168	0.86903670
59	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.85562850
60	Viral myocarditis_Homo sapiens_hsa05416	0.84440616
61	Primary immunodeficiency_Homo sapiens_hsa05340	0.80346364
62	Fatty acid degradation_Homo sapiens_hsa00071	0.77389881
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77177993
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.72345475
65	Metabolic pathways_Homo sapiens_hsa01100	0.72283502
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.72210443
67	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.71057316
68	Phototransduction_Homo sapiens_hsa04744	0.70324125
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67842355
70	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.67384807
71	Pentose phosphate pathway_Homo sapiens_hsa00030	0.67003417
72	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.66960276
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.65661208
74	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.64640824
75	Linoleic acid metabolism_Homo sapiens_hsa00591	0.61344626
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.59371652
77	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.59250794
78	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58186554
79	Folate biosynthesis_Homo sapiens_hsa00790	0.56624156
80	Cell cycle_Homo sapiens_hsa04110	0.55528765
81	Arginine biosynthesis_Homo sapiens_hsa00220	0.53783173
82	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.53361243
83	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.51783302
84	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.51674949
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.49726598
86	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47075066
87	Phagosome_Homo sapiens_hsa04145	0.46723070
88	Alzheimers disease_Homo sapiens_hsa05010	0.45186500
89	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.44010537
90	Other glycan degradation_Homo sapiens_hsa00511	0.41676440
91	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.41323171
92	Chemical carcinogenesis_Homo sapiens_hsa05204	0.39115589
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.38720915
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.38492341
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.38111723
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36797727
97	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.35451374
98	Taste transduction_Homo sapiens_hsa04742	0.35377386
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34625616
100	Ether lipid metabolism_Homo sapiens_hsa00565	0.33361721

ULK4P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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