UMOD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.66791052
2aminoglycoside antibiotic metabolic process (GO:0030647)9.38077328
3cardiovascular system development (GO:0072358)9.25320680
4lysine metabolic process (GO:0006553)9.08426875
5lysine catabolic process (GO:0006554)9.08426875
6drug transport (GO:0015893)8.27783900
7organic cation transport (GO:0015695)8.17437208
8phosphate ion transport (GO:0006817)7.94465906
9response to water (GO:0009415)7.87903853
10response to mercury ion (GO:0046689)7.36580230
11positive regulation of catenin import into nucleus (GO:0035413)7.15249028
12response to lead ion (GO:0010288)7.11830597
13renal absorption (GO:0070293)6.92708330
14activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)6.87255604
15positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)6.87179522
16* excretion (GO:0007588)6.85990552
17positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc6.85541365
18phosphate ion transmembrane transport (GO:0035435)6.75429907
19quaternary ammonium group transport (GO:0015697)6.52121579
20cysteine metabolic process (GO:0006534)6.42695521
21negative regulation of sterol transport (GO:0032372)6.28315114
22negative regulation of cholesterol transport (GO:0032375)6.28315114
23glyoxylate metabolic process (GO:0046487)6.24134091
24mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)6.22413653
25response to thyroid hormone (GO:0097066)6.17319798
26* metanephric epithelium development (GO:0072207)6.11762044
27aspartate family amino acid catabolic process (GO:0009068)6.04134381
28regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)6.01378711
29negative regulation of metanephros development (GO:0072217)5.94870641
30nephron tubule formation (GO:0072079)5.88057587
31tricarboxylic acid metabolic process (GO:0072350)5.87736621
32regulation of apoptotic process involved in morphogenesis (GO:1902337)5.72208471
33response to magnesium ion (GO:0032026)5.68938992
34vitamin D metabolic process (GO:0042359)5.58957870
35short-chain fatty acid metabolic process (GO:0046459)5.48868668
36regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.47165592
37hyperosmotic response (GO:0006972)5.45513778
38nonribosomal peptide biosynthetic process (GO:0019184)5.45216899
39drug catabolic process (GO:0042737)5.42511051
40sodium-independent organic anion transport (GO:0043252)5.41646307
41polyol transport (GO:0015791)5.39100507
42response to copper ion (GO:0046688)5.33925130
43inositol metabolic process (GO:0006020)5.28377779
44valine metabolic process (GO:0006573)5.25270761
45branched-chain amino acid metabolic process (GO:0009081)5.21155575
462-oxoglutarate metabolic process (GO:0006103)5.20636337
47homocysteine metabolic process (GO:0050667)5.20588727
48toxin transport (GO:1901998)5.17568906
49tryptophan catabolic process (GO:0006569)5.01739519
50indole-containing compound catabolic process (GO:0042436)5.01739519
51indolalkylamine catabolic process (GO:0046218)5.01739519
52amino-acid betaine transport (GO:0015838)4.95566910
53carnitine transport (GO:0015879)4.95566910
54response to vitamin A (GO:0033189)4.92989334
55exogenous drug catabolic process (GO:0042738)4.92068407
56glutathione biosynthetic process (GO:0006750)4.91687269
57cellular response to ammonium ion (GO:0071242)4.91490132
58aromatic amino acid family catabolic process (GO:0009074)4.91288400
59bone remodeling (GO:0046849)4.85539175
60* nephron tubule development (GO:0072080)4.85368117
61modified amino acid transport (GO:0072337)4.83232309
62negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.81100828
63pattern specification involved in kidney development (GO:0061004)4.78790712
64regulation of protein localization to cell surface (GO:2000008)4.73941618
65tryptophan metabolic process (GO:0006568)4.71573042
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.65352354
67L-phenylalanine metabolic process (GO:0006558)4.65352354
68trivalent inorganic anion homeostasis (GO:0072506)4.64428686
69phosphate ion homeostasis (GO:0055062)4.64428686
70renal system process (GO:0003014)4.58735640
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.56483015
72L-phenylalanine catabolic process (GO:0006559)4.56483015
73mammary gland alveolus development (GO:0060749)4.47581875
74amino-acid betaine metabolic process (GO:0006577)4.45074017
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.40941275
76acetyl-CoA metabolic process (GO:0006084)4.40636163
77branched-chain amino acid catabolic process (GO:0009083)4.39979099
78fatty acid beta-oxidation (GO:0006635)4.37789025
79positive regulation of peptidyl-threonine phosphorylation (GO:0010800)4.37265412
80cellular ketone body metabolic process (GO:0046950)4.35323864
81cellular modified amino acid catabolic process (GO:0042219)4.35265361
82ERK1 and ERK2 cascade (GO:0070371)4.32507275
83* renal tubule development (GO:0061326)4.31422879
84serine family amino acid catabolic process (GO:0009071)4.26464568
85glycoside metabolic process (GO:0016137)4.26358007
86kynurenine metabolic process (GO:0070189)4.25091372
87serine family amino acid metabolic process (GO:0009069)4.24646134
88fructose metabolic process (GO:0006000)4.23750610
89proline metabolic process (GO:0006560)4.21716318
90protein depolymerization (GO:0051261)4.20521866
91response to salt stress (GO:0009651)4.18522624
92glutamate metabolic process (GO:0006536)4.16981800
93carnitine metabolic process (GO:0009437)4.16805021
94regulation of fever generation (GO:0031620)4.08522575
95glomerular visceral epithelial cell development (GO:0072015)4.07469505
96fatty acid oxidation (GO:0019395)4.06941896
97response to phenylpropanoid (GO:0080184)4.05887256
98regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:24.00854304
99lipid oxidation (GO:0034440)3.99260435
100positive regulation of heat generation (GO:0031652)3.95243316
101* nephron epithelium development (GO:0072009)3.94386931
102peptide biosynthetic process (GO:0043043)3.91184110
103regulation of potassium ion transmembrane transporter activity (GO:1901016)3.88736060
104NADH metabolic process (GO:0006734)3.85052619
105cell differentiation involved in metanephros development (GO:0072202)3.84434953
106urogenital system development (GO:0001655)3.82946441
107L-methionine biosynthetic process (GO:0071265)3.82004032
108amino acid salvage (GO:0043102)3.82004032
109L-methionine salvage (GO:0071267)3.82004032
110beta-amyloid metabolic process (GO:0050435)3.78848599
111S-adenosylmethionine metabolic process (GO:0046500)3.78539977
112regulation of cholesterol efflux (GO:0010874)3.77698334
113ketone body metabolic process (GO:1902224)3.74393770
114regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.73958806
115positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.72017871
116* metanephric nephron tubule development (GO:0072234)3.67070895
117* metanephric tubule development (GO:0072170)3.67070895
118regulation of mesenchymal cell apoptotic process (GO:2001053)3.66131673
119peptide catabolic process (GO:0043171)3.65087438
120response to growth hormone (GO:0060416)3.64342503
121cellular amino acid catabolic process (GO:0009063)3.62628462
122vitamin transport (GO:0051180)3.60903935
123aromatic amino acid family metabolic process (GO:0009072)3.60527047
124fatty acid catabolic process (GO:0009062)3.58572398
125glomerular epithelial cell development (GO:0072310)3.57650600
126indole-containing compound metabolic process (GO:0042430)3.56356152
127mesonephros development (GO:0001823)3.55757129
128alpha-amino acid catabolic process (GO:1901606)3.54653758
129positive regulation of ERBB signaling pathway (GO:1901186)3.52067553
130indolalkylamine metabolic process (GO:0006586)3.49487352
131sodium ion transport (GO:0006814)3.47933389
132nephron epithelium morphogenesis (GO:0072088)3.45709479
133nephron tubule morphogenesis (GO:0072078)3.45709479
134biotin metabolic process (GO:0006768)3.45302113
135regulation of stem cell maintenance (GO:2000036)3.44669243
136tricarboxylic acid cycle (GO:0006099)3.44617113
137glutathione derivative biosynthetic process (GO:1901687)3.44529008
138glutathione derivative metabolic process (GO:1901685)3.44529008
139surfactant homeostasis (GO:0043129)3.43685552
140regulation of anion transport (GO:0044070)3.43576694
141regulation of catenin import into nucleus (GO:0035412)3.42682469
142* metanephric nephron epithelium development (GO:0072243)3.39183071
143succinate metabolic process (GO:0006105)3.38328036
144collecting duct development (GO:0072044)3.38244618
145cellular response to vitamin D (GO:0071305)3.38034360
146glutathione metabolic process (GO:0006749)3.37939969
147sulfur compound transport (GO:0072348)3.37145201
148response to lithium ion (GO:0010226)3.36145407
149regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.34933701
150monocarboxylic acid catabolic process (GO:0072329)3.34428633
151inorganic anion transport (GO:0015698)3.34378506
152transepithelial transport (GO:0070633)3.34322341
153regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.33131586
154response to parathyroid hormone (GO:0071107)3.32342870
155organic acid catabolic process (GO:0016054)3.32329723
156carboxylic acid catabolic process (GO:0046395)3.32329723
157serine family amino acid biosynthetic process (GO:0009070)3.32094208
158negative regulation of kidney development (GO:0090185)3.31841005
159oxaloacetate metabolic process (GO:0006107)3.29944526
160dicarboxylic acid metabolic process (GO:0043648)3.28812035
161cell volume homeostasis (GO:0006884)3.24948774
162chloride transmembrane transport (GO:1902476)3.24512191
163sulfur amino acid catabolic process (GO:0000098)3.24071726
164oligosaccharide catabolic process (GO:0009313)3.23076433
165regulation of heat generation (GO:0031650)3.18130476
166regulation of calcium ion import (GO:0090279)3.17446061
167glycine metabolic process (GO:0006544)3.16828018
168inorganic anion transmembrane transport (GO:0098661)3.13586127
169mesenchymal to epithelial transition (GO:0060231)3.10204780
170regulation of potassium ion transmembrane transport (GO:1901379)3.09164252
171positive regulation of metanephros development (GO:0072216)3.02921952
172actin filament depolymerization (GO:0030042)11.4912383
173urate metabolic process (GO:0046415)10.0878909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.88851759
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.83788397
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.34803434
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.00869247
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.70659776
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.66668191
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.80054799
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.65709755
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.65581297
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.63144976
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.61502238
12CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.60592408
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60059751
14CLOCK_20551151_ChIP-Seq_293T_Human2.49236345
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.48332239
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.47629258
17VDR_22108803_ChIP-Seq_LS180_Human2.32665088
18AR_21909140_ChIP-Seq_LNCAP_Human2.27032789
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.10970545
20TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.10602197
21KLF4_18555785_Chip-Seq_ESCs_Mouse2.05820510
22CDX2_20551321_ChIP-Seq_CACO-2_Human2.01258290
23P53_22127205_ChIP-Seq_FIBROBLAST_Human1.90830638
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88663845
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.87219172
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84102434
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81729085
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79344901
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77670471
30E2F1_18555785_Chip-Seq_ESCs_Mouse1.76022612
31NANOG_18555785_Chip-Seq_ESCs_Mouse1.70883002
32NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.68879679
33EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.66240009
34GATA4_25053715_ChIP-Seq_YYC3_Human1.64202620
35OCT4_18555785_Chip-Seq_ESCs_Mouse1.63685606
36STAT3_18555785_Chip-Seq_ESCs_Mouse1.60937194
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57864820
38GATA1_22025678_ChIP-Seq_K562_Human1.55701717
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.55527516
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.54417361
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51358131
42DROSHA_22980978_ChIP-Seq_HELA_Human1.49757516
43SMAD4_21799915_ChIP-Seq_A2780_Human1.49136559
44LXR_22292898_ChIP-Seq_THP-1_Human1.45724307
45ZFX_18555785_Chip-Seq_ESCs_Mouse1.45631838
46P300_18555785_Chip-Seq_ESCs_Mouse1.45614558
47HNF4A_19822575_ChIP-Seq_HepG2_Human1.45393791
48CBP_21632823_ChIP-Seq_H3396_Human1.45314659
49SUZ12_18555785_Chip-Seq_ESCs_Mouse1.44939961
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43652002
51P53_22387025_ChIP-Seq_ESCs_Mouse1.41791825
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40894611
53EGR1_19032775_ChIP-ChIP_M12_Human1.37586956
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36866234
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.36363225
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34633353
57TCF4_22108803_ChIP-Seq_LS180_Human1.31084158
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30818721
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30742636
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30088526
61SOX2_18555785_Chip-Seq_ESCs_Mouse1.29644567
62RACK7_27058665_Chip-Seq_MCF-7_Human1.29629027
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29426819
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29244816
65PU1_27457419_Chip-Seq_LIVER_Mouse1.29026962
66ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28233708
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.28161527
68RUNX1_27457419_Chip-Seq_LIVER_Mouse1.27326792
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26381279
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26281069
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26056368
72GATA6_25053715_ChIP-Seq_YYC3_Human1.24554674
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24214511
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22385523
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.22043789
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21946557
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.21248926
78SMAD3_21741376_ChIP-Seq_HESCs_Human1.20982620
79TBX20_22080862_ChIP-Seq_HEART_Mouse1.20410823
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.20410823
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.19987299
82GBX2_23144817_ChIP-Seq_PC3_Human1.19783684
83PHF8_20622853_ChIP-Seq_HELA_Human1.18226150
84RXR_22108803_ChIP-Seq_LS180_Human1.17709182
85KDM2B_26808549_Chip-Seq_REH_Human1.17696219
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17218700
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15040146
88CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12654936
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11963396
90TBL1_22424771_ChIP-Seq_293T_Human1.11861897
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11342495
92SOX2_20726797_ChIP-Seq_SW620_Human1.10554832
93NFYA_21822215_ChIP-Seq_K562_Human1.09491372
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09007003
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.08674644
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08150558
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07657019
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.07203800
99PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07119715
100TAF15_26573619_Chip-Seq_HEK293_Human1.07078650
101SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07075867
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06696208
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06213210
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05351796
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04668245
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04420442
107EP300_21415370_ChIP-Seq_HL-1_Mouse1.04146265
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03880499
109SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03614771
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02994626
111NMYC_18555785_Chip-Seq_ESCs_Mouse1.02923817
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02713126
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.02335734
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01998160
115GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00805124
116CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00201005
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98868602
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.98745766
119RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98361227
120EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98361227
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.97612420
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96209535
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.93149434
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90806816
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90278355
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89915042
127P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89713113
128VDR_24787735_ChIP-Seq_THP-1_Human0.88688756
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88182458
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86183471
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85861811
132NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85378348
133CDX2_22108803_ChIP-Seq_LS180_Human0.84800993
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83269057
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82478882
136SOX11_22085726_ChIP-Seq_ESNs_Mouse0.81321807
137TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80193208
138GATA2_19941826_ChIP-Seq_K562_Human0.80113187
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79510053
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78615196
141TP63_23658742_ChIP-Seq_EP156T_Human0.78001378
142RAC3_21632823_ChIP-Seq_H3396_Human0.77794479
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76877439
144MTF2_20144788_ChIP-Seq_MESCs_Mouse0.76811032
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76426477
146MYC_19915707_ChIP-ChIP_AK7_Human0.76158085
147CREB1_26743006_Chip-Seq_LNCaP_Human0.75895165
148SMC4_20622854_ChIP-Seq_HELA_Human0.75501632
149P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75346933
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75240367
151NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.73729820
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73598187
153EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73583373
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72632870
155NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72632870
156AHR_22903824_ChIP-Seq_MCF-7_Human0.70961698
157CJUN_26792858_Chip-Seq_BT549_Human0.69725038
158CSB_26484114_Chip-Seq_FIBROBLAST_Human0.69371805
159GATA1_19941826_ChIP-Seq_K562_Human0.68988694
160ARNT_22903824_ChIP-Seq_MCF-7_Human0.68846221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation7.72937175
2MP0005360_urolithiasis7.48025854
3MP0003195_calcinosis5.60756144
4MP0004019_abnormal_vitamin_homeostasis4.76393552
5* MP0005332_abnormal_amino_acid4.58920046
6* MP0009643_abnormal_urine_homeostasis4.05681252
7MP0002139_abnormal_hepatobiliary_system3.91984046
8* MP0001765_abnormal_ion_homeostasis3.77718899
9MP0002138_abnormal_hepatobiliary_system3.68101495
10* MP0001756_abnormal_urination3.53437975
11* MP0002136_abnormal_kidney_physiology3.10990951
12* MP0005636_abnormal_mineral_homeostasis3.04380157
13MP0003878_abnormal_ear_physiology2.78689381
14MP0005377_hearing/vestibular/ear_phenot2.78689381
15MP0008875_abnormal_xenobiotic_pharmacok2.55495726
16MP0001958_emphysema2.48803707
17MP0003252_abnormal_bile_duct2.45008900
18MP0005365_abnormal_bile_salt2.20475930
19MP0004885_abnormal_endolymph1.94404449
20MP0000538_abnormal_urinary_bladder1.87549574
21MP0005085_abnormal_gallbladder_physiolo1.85912748
22MP0005058_abnormal_lysosome_morphology1.75433094
23MP0003186_abnormal_redox_activity1.59937151
24MP0005584_abnormal_enzyme/coenzyme_acti1.57283858
25MP0003300_gastrointestinal_ulcer1.47462072
26MP0000230_abnormal_systemic_arterial1.44863998
27MP0002168_other_aberrant_phenotype1.44834473
28MP0005451_abnormal_body_composition1.37496500
29MP0002928_abnormal_bile_duct1.28355523
30MP0005319_abnormal_enzyme/_coenzyme1.26296852
31MP0002876_abnormal_thyroid_physiology1.24550021
32MP0006036_abnormal_mitochondrial_physio1.22550092
33MP0003045_fibrosis1.22514439
34MP0003283_abnormal_digestive_organ1.21896594
35* MP0002135_abnormal_kidney_morphology1.18222531
36MP0005084_abnormal_gallbladder_morpholo1.15159554
37MP0003806_abnormal_nucleotide_metabolis1.11933066
38MP0003191_abnormal_cellular_cholesterol1.02312078
39MP0010234_abnormal_vibrissa_follicle0.98082860
40MP0001764_abnormal_homeostasis0.96268509
41MP0005670_abnormal_white_adipose0.95446550
42MP0002896_abnormal_bone_mineralization0.93686246
43MP0005666_abnormal_adipose_tissue0.91401869
44MP0009672_abnormal_birth_weight0.91280343
45MP0001666_abnormal_nutrient_absorption0.90035923
46MP0004147_increased_porphyrin_level0.85599640
47MP0003638_abnormal_response/metabolism_0.85057045
48MP0004264_abnormal_extraembryonic_tissu0.82409501
49MP0001661_extended_life_span0.82154723
50MP0003646_muscle_fatigue0.79686577
51MP0005395_other_phenotype0.76820683
52* MP0005535_abnormal_body_temperature0.76684512
53MP0002089_abnormal_postnatal_growth/wei0.74829407
54* MP0002118_abnormal_lipid_homeostasis0.71902236
55* MP0009642_abnormal_blood_homeostasis0.71782599
56MP0005220_abnormal_exocrine_pancreas0.69694056
57MP0003183_abnormal_peptide_metabolism0.69607276
58MP0001191_abnormal_skin_condition0.67110578
59MP0000534_abnormal_ureter_morphology0.65722086
60MP0010386_abnormal_urinary_bladder0.63874371
61MP0004272_abnormal_basement_membrane0.61703969
62MP0002796_impaired_skin_barrier0.60735935
63MP0009764_decreased_sensitivity_to0.59795187
64MP0000747_muscle_weakness0.59683015
65MP0003943_abnormal_hepatobiliary_system0.59043365
66MP0010329_abnormal_lipoprotein_level0.58207166
67MP0003172_abnormal_lysosome_physiology0.58022490
68MP0005165_increased_susceptibility_to0.57288533
69MP0000609_abnormal_liver_physiology0.55026385
70MP0004742_abnormal_vestibular_system0.53550632
71MP0003938_abnormal_ear_development0.52598201
72MP0008469_abnormal_protein_level0.50249528
73MP0002971_abnormal_brown_adipose0.49847859
74MP0003329_amyloid_beta_deposits0.48963083
75MP0002069_abnormal_eating/drinking_beha0.48657226
76MP0003315_abnormal_perineum_morphology0.47835311
77MP0001485_abnormal_pinna_reflex0.47707977
78MP0004484_altered_response_of0.45635232
79MP0001270_distended_abdomen0.45219418
80MP0002078_abnormal_glucose_homeostasis0.45055269
81MP0000371_diluted_coat_color0.44555043
82MP0000598_abnormal_liver_morphology0.43776040
83MP0002998_abnormal_bone_remodeling0.42997443
84MP0005167_abnormal_blood-brain_barrier0.42710123
85MP0005501_abnormal_skin_physiology0.42166276
86MP0003953_abnormal_hormone_level0.41806967
87MP0002115_abnormal_skeleton_extremities0.41661119
88MP0003879_abnormal_hair_cell0.41053726
89MP0006035_abnormal_mitochondrial_morpho0.40703044
90MP0009703_decreased_birth_body0.40290498
91MP0001731_abnormal_postnatal_growth0.39945207
92MP0005375_adipose_tissue_phenotype0.38857205
93MP0005408_hypopigmentation0.37842942
94MP0003221_abnormal_cardiomyocyte_apopto0.37302390
95MP0001944_abnormal_pancreas_morphology0.36563192
96MP0004233_abnormal_muscle_weight0.36511319
97MP0004858_abnormal_nervous_system0.35817695
98MP0002098_abnormal_vibrissa_morphology0.35440182
99* MP0003795_abnormal_bone_structure0.35125290
100MP0000026_abnormal_inner_ear0.34836491
101MP0003941_abnormal_skin_development0.34636018
102MP0008004_abnormal_stomach_pH0.32871212
103MP0008872_abnormal_physiological_respon0.31819441
104MP0001963_abnormal_hearing_physiology0.31597477
105MP0000678_abnormal_parathyroid_gland0.31344716
106MP0003075_altered_response_to0.30439587
107MP0002972_abnormal_cardiac_muscle0.30332779
108MP0001663_abnormal_digestive_system0.29619080
109MP0008775_abnormal_heart_ventricle0.29418687
110MP0001177_atelectasis0.29245929
111MP0000163_abnormal_cartilage_morphology0.29208942
112MP0000631_abnormal_neuroendocrine_gland0.28849898
113MP0001727_abnormal_embryo_implantation0.28563933
114MP0010368_abnormal_lymphatic_system0.28033547
115MP0001664_abnormal_digestion0.27799570
116MP0002108_abnormal_muscle_morphology0.26791168
117MP0004215_abnormal_myocardial_fiber0.24985481
118MP0001784_abnormal_fluid_regulation0.23441821
119MP0010770_preweaning_lethality0.22920844
120MP0002082_postnatal_lethality0.22920844
121MP0000566_synostosis0.21813151
122MP0010769_abnormal_survival0.18119925
123MP0008874_decreased_physiological_sensi0.17931130
124MP0010768_mortality/aging0.16135093
125MP0003137_abnormal_impulse_conducting0.15728076
126MP0000681_abnormal_thyroid_gland0.15230783
127MP0003011_delayed_dark_adaptation0.15112926
128MP0000013_abnormal_adipose_tissue0.12937391
129MP0000762_abnormal_tongue_morphology0.12005916
130MP0005409_darkened_coat_color0.11361214
131MP0009780_abnormal_chondrocyte_physiolo0.10768928
132MP0003942_abnormal_urinary_system0.10519168
133MP0000467_abnormal_esophagus_morphology0.06997015
134MP0000367_abnormal_coat/_hair0.06367132
135MP0002113_abnormal_skeleton_development0.05425298
136MP0001346_abnormal_lacrimal_gland0.05415261

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)9.28040558
2Hypokalemic alkalosis (HP:0001949)9.00102691
3Metabolic alkalosis (HP:0200114)8.89043156
4Hypomagnesemia (HP:0002917)8.23295120
5Hyperactive renin-angiotensin system (HP:0000841)7.93577162
6Polyuria (HP:0000103)7.70193817
7Abnormality of chloride homeostasis (HP:0011422)7.42825309
8Abnormal urine output (HP:0012590)7.20913517
9Abnormality of magnesium homeostasis (HP:0004921)6.98797647
10Abnormality of renal excretion (HP:0011036)6.62837898
11Polydipsia (HP:0001959)6.21582142
12Abnormal drinking behavior (HP:0030082)6.21582142
13Tetany (HP:0001281)6.12106850
14Renal salt wasting (HP:0000127)5.87205025
15Hyperaldosteronism (HP:0000859)5.78211347
16Abnormality of renin-angiotensin system (HP:0000847)5.60382424
17Alkalosis (HP:0001948)5.57511339
18Proximal tubulopathy (HP:0000114)4.66670012
19Hypokalemia (HP:0002900)4.44881476
20Hyperglycinuria (HP:0003108)4.26532399
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.17851296
22Hypercalciuria (HP:0002150)4.10137172
23* Gout (HP:0001997)3.80674684
24Abnormality of potassium homeostasis (HP:0011042)3.67591981
25Abnormality of glycine metabolism (HP:0010895)3.50442343
26Abnormality of serine family amino acid metabolism (HP:0010894)3.50442343
27Ketoacidosis (HP:0001993)3.47852329
28* Hyperuricemia (HP:0002149)3.46060931
29* Increased purine levels (HP:0004368)3.46060931
30Renal tubular acidosis (HP:0001947)3.39718531
31Large eyes (HP:0001090)3.36082544
32Generalized aminoaciduria (HP:0002909)3.29155307
33Abnormality of fatty-acid metabolism (HP:0004359)3.14809361
34* Abnormality of purine metabolism (HP:0004352)3.13276198
35Nephrocalcinosis (HP:0000121)3.00788412
36Abnormality of urine glucose concentration (HP:0011016)3.00114965
37Glycosuria (HP:0003076)3.00114965
38Abnormality of sodium homeostasis (HP:0010931)2.98478298
39Ketosis (HP:0001946)2.91196202
40Hyponatremia (HP:0002902)2.78511005
41Adrenal overactivity (HP:0002717)2.71919449
42Hyperphosphaturia (HP:0003109)2.68615938
43Dehydration (HP:0001944)2.64851540
44Abnormality of proline metabolism (HP:0010907)2.62900274
45Hydroxyprolinuria (HP:0003080)2.62900274
46Abnormal urine phosphate concentration (HP:0012599)2.55276807
47Delayed epiphyseal ossification (HP:0002663)2.51844063
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.47554367
49Chondrocalcinosis (HP:0000934)2.47117969
50Nephrolithiasis (HP:0000787)2.46972084
51Hyperglycinemia (HP:0002154)2.40653681
52Delayed CNS myelination (HP:0002188)2.36853636
53Abnormality of Sharpey fibers (HP:0100685)2.32597732
54* Abnormality of nucleobase metabolism (HP:0010932)2.26164058
55Hypophosphatemia (HP:0002148)2.22878639
56Vomiting (HP:0002013)2.21311988
57Vascular calcification (HP:0004934)2.16640543
58Metaphyseal cupping (HP:0003021)2.13137423
59Tubulointerstitial fibrosis (HP:0005576)2.11914267
60Potter facies (HP:0002009)2.11646790
61Facial shape deformation (HP:0011334)2.11646790
62Hyperammonemia (HP:0001987)2.11370160
63Rickets (HP:0002748)2.06989292
64Renal tubular dysfunction (HP:0000124)2.05240881
65Generalized muscle weakness (HP:0003324)2.05202057
66Metabolic acidosis (HP:0001942)2.04204113
67Dicarboxylic aciduria (HP:0003215)2.03573452
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03573452
69Widely patent fontanelles and sutures (HP:0004492)2.03531875
70Decreased circulating renin level (HP:0003351)2.00384245
71Hypotension (HP:0002615)1.98903116
72Vacuolated lymphocytes (HP:0001922)1.98437465
73Enlarged kidneys (HP:0000105)1.96674388
74Abnormality of renal resorption (HP:0011038)1.94000947
75Cardiovascular calcification (HP:0011915)1.92927001
76Abnormality of sulfur amino acid metabolism (HP:0004339)1.89975336
77Glomerulosclerosis (HP:0000096)1.84284775
78Confusion (HP:0001289)1.81454653
79Malnutrition (HP:0004395)1.81167900
80Bilateral sensorineural hearing impairment (HP:0008619)1.80757329
81Lethargy (HP:0001254)1.77531652
82Abnormality of aromatic amino acid family metabolism (HP:0004338)1.73651695
83Thin bony cortex (HP:0002753)1.71769336
84Abnormal platelet function (HP:0011869)1.70779532
85Impaired platelet aggregation (HP:0003540)1.70779532
86Lymphangioma (HP:0100764)1.70020578
87Abnormal enzyme/coenzyme activity (HP:0012379)1.69435969
88Methylmalonic aciduria (HP:0012120)1.69073171
89Neonatal onset (HP:0003623)1.66642357
90Abnormality of alkaline phosphatase activity (HP:0004379)1.64260021
91Abnormal tarsal ossification (HP:0008369)1.64087834
92Bicornuate uterus (HP:0000813)1.62586199
93Hyperkalemia (HP:0002153)1.57688143
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.57269926
95Irritability (HP:0000737)1.56864639
96Nausea (HP:0002018)1.53183838
97Focal segmental glomerulosclerosis (HP:0000097)1.51216485
98Nephrogenic diabetes insipidus (HP:0009806)1.48531550
99Tachypnea (HP:0002789)1.46705088
100Abnormality of the costochondral junction (HP:0000919)1.45953691
101Premature birth (HP:0001622)1.45113594
102Abnormality of serum amino acid levels (HP:0003112)1.39995548
103Abnormal eating behavior (HP:0100738)1.39864379
104Metaphyseal dysplasia (HP:0100255)1.39485065
105Abnormality of the renal cortex (HP:0011035)1.38750426
106Metaphyseal irregularity (HP:0003025)1.38180311
107Osteopenia (HP:0000938)1.34774767
108Paresthesia (HP:0003401)1.30068433
109Hypothermia (HP:0002045)1.26427330
110Intellectual disability, moderate (HP:0002342)1.10250896
111Tubulointerstitial abnormality (HP:0001969)1.10214177
112Elevated alkaline phosphatase (HP:0003155)1.09837198
113Abnormality of calcium-phosphate metabolism (HP:0100530)1.06568161
114Polyhydramnios (HP:0001561)1.05697566
115Small for gestational age (HP:0001518)1.05194016
116Neonatal death (HP:0003811)1.03373084
117Thyroid-stimulating hormone excess (HP:0002925)0.93129419
118Persistence of primary teeth (HP:0006335)0.87919698
119Osteomalacia (HP:0002749)0.78278602
120Hyperphosphatemia (HP:0002905)0.76166764
121Hypophosphatemic rickets (HP:0004912)0.76161187
122Abnormality of the fingertips (HP:0001211)0.75411803
123Enlarged epiphyses (HP:0010580)0.74971753
124Abnormality of macular pigmentation (HP:0008002)0.74622086
125Esophageal varix (HP:0002040)0.71524291
126Abnormal foot bone ossification (HP:0010675)0.64655885
127Amelogenesis imperfecta (HP:0000705)0.64263794
128Pancreatic cysts (HP:0001737)0.63614644
129Stage 5 chronic kidney disease (HP:0003774)0.62619337
130* Tubular atrophy (HP:0000092)0.61059041
131Choanal stenosis (HP:0000452)0.58968191
132Visceral angiomatosis (HP:0100761)0.58825131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK39.24167215
2WNK48.85390417
3OXSR18.15719158
4STK394.68314577
5BCKDK2.15634620
6STK38L1.82174947
7WNK11.80143893
8SGK2231.77274252
9SGK4941.77274252
10PDK31.60262776
11PDK41.60262776
12NEK11.46859141
13PDK21.29273941
14SGK21.25424267
15SGK31.13255763
16MST40.96955660
17STK380.93842819
18TIE10.88817614
19MST1R0.88308291
20LRRK20.79091753
21TGFBR20.69531056
22FGFR40.63983074
23EPHB10.58909968
24GSK3A0.55907842
25PINK10.55270492
26SGK10.53139497
27MAP3K70.49725509
28ERN10.45869702
29GRK60.45813443
30PRKAA10.44031345
31MAP3K30.42536810
32PAK40.41432618
33PTK20.39344899
34PTK60.34892218
35ABL20.33630388
36PDPK10.33363955
37DYRK1B0.32202439
38TRIB30.30166324
39FER0.29705662
40PAK30.27798859
41PRKD20.26693114
42PRKAA20.25513337
43STK100.25285991
44MET0.24062531
45MYLK0.23936473
46MAPK110.23928460
47RIPK10.23518489
48INSRR0.23074977
49PRKCI0.22844314
50PIK3CG0.21480178
51PTK2B0.21376675
52NTRK10.21049858
53PDK10.20636323
54MAPK150.19415346
55PRKCZ0.19111397
56PRKCH0.16818127
57PRKCD0.16005105
58LATS10.15918185
59MAP3K20.15868077
60KDR0.15075901
61MAP3K140.13836136
62PRKACG0.13322644
63FRK0.12685316
64EPHB20.12190106
65STK110.11955625
66MAP2K30.11425823
67TGFBR10.10713717
68JAK20.10015838
69AKT20.09936043
70BMX0.09090688
71SCYL20.08245064
72PRKACA0.07692328
73MINK10.07686197
74PRKCA0.07476205
75ERBB40.06955547
76NME20.06143731
77NLK0.05659590
78IRAK20.05582772
79ROCK10.05086455
80EPHA30.04969873
81TESK10.04269338
82MAPK120.04159072
83CSNK1A10.03629970
84PDGFRA0.03356544
85FGFR30.03338637
86PRKCB0.02969683
87PIM10.02518757
88SRC0.02293572
89AKT30.02248635
90MAP3K110.01517848
91CSNK1A1L0.01346555
92PRKD30.01013556
93KSR20.00669321
94BRSK20.00644352
95INSR0.00439116
96RET0.00236721
97EPHA40.00101222
98BTK-0.0878783
99AURKB-0.0859066
100PRKACB-0.0848090
101MAP3K1-0.0837103
102ADRBK2-0.0825285
103CAMK2B-0.0818625
104DMPK-0.0804106
105MAPK3-0.0794247
106CSF1R-0.0782563
107PRKG1-0.0776820
108FYN-0.0774843
109MELK-0.0719797
110KSR1-0.0712806
111PIK3CA-0.0711115
112LATS2-0.0659036
113MAPK8-0.0652262
114JAK1-0.0600718
115MAPK10-0.0595191
116ROCK2-0.0584001
117PRKCE-0.0562639
118NTRK3-0.0474100
119NEK9-0.0436258
120ABL1-0.0413680
121FGFR2-0.0411102
122CDC42BPA-0.0394405
123PRKD1-0.0385990
124PKN2-0.0382109
125CAMK4-0.0348427
126BCR-0.0346915
127MAP2K4-0.0343237
128DAPK2-0.0306469
129RPS6KA3-0.0277332
130GRK1-0.0266935
131PRKCG-0.0241960
132IRAK1-0.0236329
133MARK3-0.0223115
134CSK-0.0214582
135PRKCQ-0.0204254
136TRPM7-0.0171148
137MTOR-0.0148884
138YES1-0.0148493
139CAMKK2-0.0067450
140IGF1R-0.0061565
141STK3-0.0039282

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.76561144
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.60724174
3Butanoate metabolism_Homo sapiens_hsa006503.53440493
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.32685636
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.29045808
6Propanoate metabolism_Homo sapiens_hsa006403.28042108
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.27575804
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.25312032
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.89664237
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.67541459
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.49384477
12Collecting duct acid secretion_Homo sapiens_hsa049662.38066996
13Peroxisome_Homo sapiens_hsa041462.37574567
14Fatty acid degradation_Homo sapiens_hsa000712.35910722
15Pyruvate metabolism_Homo sapiens_hsa006202.26694276
16Tryptophan metabolism_Homo sapiens_hsa003802.22000806
17Vitamin digestion and absorption_Homo sapiens_hsa049772.08481493
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97807777
19Bile secretion_Homo sapiens_hsa049761.83942323
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82191359
21beta-Alanine metabolism_Homo sapiens_hsa004101.81317782
22Carbon metabolism_Homo sapiens_hsa012001.75730788
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75039032
24Fatty acid metabolism_Homo sapiens_hsa012121.73328444
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71589683
26Sulfur metabolism_Homo sapiens_hsa009201.67271176
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.60887603
28Glutathione metabolism_Homo sapiens_hsa004801.60229349
29Endometrial cancer_Homo sapiens_hsa052131.56722192
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40763311
31Protein digestion and absorption_Homo sapiens_hsa049741.40292087
32Non-small cell lung cancer_Homo sapiens_hsa052231.38682148
33Mineral absorption_Homo sapiens_hsa049781.35848614
34Lysine degradation_Homo sapiens_hsa003101.35670290
35Arginine biosynthesis_Homo sapiens_hsa002201.27211697
36Pancreatic cancer_Homo sapiens_hsa052121.26602467
37PPAR signaling pathway_Homo sapiens_hsa033201.26456672
38Arginine and proline metabolism_Homo sapiens_hsa003301.25041750
39Nitrogen metabolism_Homo sapiens_hsa009101.22761774
40Other glycan degradation_Homo sapiens_hsa005111.21233131
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12852940
42Biosynthesis of amino acids_Homo sapiens_hsa012301.12226494
43Glioma_Homo sapiens_hsa052141.08805026
44Melanoma_Homo sapiens_hsa052181.07703865
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05313993
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00946539
47Selenocompound metabolism_Homo sapiens_hsa004500.99259832
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93486596
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.92980753
50Renin-angiotensin system_Homo sapiens_hsa046140.90911730
51Starch and sucrose metabolism_Homo sapiens_hsa005000.89853046
52Oxidative phosphorylation_Homo sapiens_hsa001900.88881574
53FoxO signaling pathway_Homo sapiens_hsa040680.83417584
54Phenylalanine metabolism_Homo sapiens_hsa003600.82850149
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82526219
56Folate biosynthesis_Homo sapiens_hsa007900.81307368
57Fructose and mannose metabolism_Homo sapiens_hsa000510.81138421
58Glycerolipid metabolism_Homo sapiens_hsa005610.80656348
59Vitamin B6 metabolism_Homo sapiens_hsa007500.80329288
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.77144616
61Histidine metabolism_Homo sapiens_hsa003400.77089729
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73808040
63Fatty acid elongation_Homo sapiens_hsa000620.71917929
64Gap junction_Homo sapiens_hsa045400.70700224
65Prostate cancer_Homo sapiens_hsa052150.70031663
66ErbB signaling pathway_Homo sapiens_hsa040120.68363457
67Lysosome_Homo sapiens_hsa041420.64198812
68Gastric acid secretion_Homo sapiens_hsa049710.63688643
69Thyroid hormone synthesis_Homo sapiens_hsa049180.62352173
70Pentose phosphate pathway_Homo sapiens_hsa000300.56569957
71Chemical carcinogenesis_Homo sapiens_hsa052040.54471320
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54438376
73HIF-1 signaling pathway_Homo sapiens_hsa040660.52736037
74Parkinsons disease_Homo sapiens_hsa050120.51032400
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50228775
76Thyroid cancer_Homo sapiens_hsa052160.50222656
77Metabolic pathways_Homo sapiens_hsa011000.49796975
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45200383
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.44025217
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.39789776
81Focal adhesion_Homo sapiens_hsa045100.39769104
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.39423775
83Vibrio cholerae infection_Homo sapiens_hsa051100.38001578
84Complement and coagulation cascades_Homo sapiens_hsa046100.36064286
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.34050881
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33062553
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.28961934
88Synaptic vesicle cycle_Homo sapiens_hsa047210.27745295
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27721869
90Cardiac muscle contraction_Homo sapiens_hsa042600.26819160
91Retinol metabolism_Homo sapiens_hsa008300.26622698
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24910101
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24709533
94ABC transporters_Homo sapiens_hsa020100.24597273
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21818261
96Rap1 signaling pathway_Homo sapiens_hsa040150.21781329
97Alzheimers disease_Homo sapiens_hsa050100.21288781
98Tyrosine metabolism_Homo sapiens_hsa003500.20851756
99Choline metabolism in cancer_Homo sapiens_hsa052310.18951489
100Circadian rhythm_Homo sapiens_hsa047100.18822667
101Sulfur relay system_Homo sapiens_hsa041220.17748436
102Arachidonic acid metabolism_Homo sapiens_hsa005900.17287742
103Steroid biosynthesis_Homo sapiens_hsa001000.17035676
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16922088
105Tight junction_Homo sapiens_hsa045300.14085439
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13719052
107Pathways in cancer_Homo sapiens_hsa052000.12823544
108Insulin resistance_Homo sapiens_hsa049310.11230398
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.10978192
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09989385
111Sphingolipid metabolism_Homo sapiens_hsa006000.08746945
112Bladder cancer_Homo sapiens_hsa052190.08427477
113Rheumatoid arthritis_Homo sapiens_hsa053230.08374637
114Huntingtons disease_Homo sapiens_hsa050160.05991926
115Inositol phosphate metabolism_Homo sapiens_hsa005620.04865374
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.03797523
117Endocytosis_Homo sapiens_hsa041440.03287741
118Pancreatic secretion_Homo sapiens_hsa049720.02698328
119Ras signaling pathway_Homo sapiens_hsa040140.02215103
120Galactose metabolism_Homo sapiens_hsa000520.02017249
121Hepatitis C_Homo sapiens_hsa051600.01837931
122AMPK signaling pathway_Homo sapiens_hsa041520.00639162
123Glucagon signaling pathway_Homo sapiens_hsa04922-0.0324919
124ECM-receptor interaction_Homo sapiens_hsa04512-0.0249193
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0188621
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0098464

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »