UNC119

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* detection of light stimulus (GO:0009583)9.64862887
2detection of visible light (GO:0009584)9.62217984
3* visual perception (GO:0007601)8.67027988
4* sensory perception of light stimulus (GO:0050953)8.56270880
5protein-chromophore linkage (GO:0018298)8.47142674
6positive regulation of guanylate cyclase activity (GO:0031284)8.32701230
7regulation of guanylate cyclase activity (GO:0031282)7.41709050
8cellular response to light stimulus (GO:0071482)7.29351499
9retina development in camera-type eye (GO:0060041)7.20797960
10photoreceptor cell differentiation (GO:0046530)6.93662216
11eye photoreceptor cell differentiation (GO:0001754)6.93662216
12* detection of external stimulus (GO:0009581)6.63970439
13* detection of abiotic stimulus (GO:0009582)6.49272255
14positive regulation by symbiont of host defense response (GO:0052509)6.01906151
15modulation by symbiont of host defense response (GO:0052031)6.01906151
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.01906151
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.01906151
18positive regulation by organism of defense response of other organism involved in symbiotic interact6.01906151
19modulation by symbiont of host immune response (GO:0052553)6.01906151
20negative regulation of cell killing (GO:0031342)5.95804005
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.95804005
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.76209862
23regulation of cGMP metabolic process (GO:0030823)5.68597420
24regulation of B cell receptor signaling pathway (GO:0050855)5.52685309
25positive regulation of gamma-delta T cell activation (GO:0046645)5.47604174
26antigen processing and presentation of endogenous antigen (GO:0019883)5.35725782
27detection of other organism (GO:0098543)5.19457495
28detection of bacterium (GO:0016045)5.18288995
29adaptation of signaling pathway (GO:0023058)5.15712536
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.01588590
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.00906618
32positive regulation of cGMP biosynthetic process (GO:0030828)4.89574040
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.75068930
34neutrophil activation involved in immune response (GO:0002283)4.73677685
35response to peptidoglycan (GO:0032494)4.69968620
36respiratory burst (GO:0045730)4.67055510
37cellular response to radiation (GO:0071478)4.61934659
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.53337850
39regulation of cGMP biosynthetic process (GO:0030826)4.53030330
40macrophage activation involved in immune response (GO:0002281)4.53006734
41peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.44200691
42leukocyte aggregation (GO:0070486)4.36200687
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35154178
44positive regulation of cGMP metabolic process (GO:0030825)4.34253841
45immunoglobulin mediated immune response (GO:0016064)4.32159376
46nonmotile primary cilium assembly (GO:0035058)4.21766515
47detection of external biotic stimulus (GO:0098581)4.20376059
48response to host immune response (GO:0052572)4.11388944
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.11388944
50cell morphogenesis involved in neuron differentiation (GO:0048667)4.10587789
51negative regulation of interleukin-12 production (GO:0032695)4.09682678
52regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.01286346
53* sensory perception (GO:0007600)4.00134525
54estrogen biosynthetic process (GO:0006703)3.98330234
55negative regulation of lymphocyte mediated immunity (GO:0002707)3.96226331
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.92927487
57prenylation (GO:0097354)3.89801696
58protein prenylation (GO:0018342)3.89801696
59response to interleukin-15 (GO:0070672)3.89782077
60neutrophil activation (GO:0042119)3.89344160
61regulation of interferon-beta biosynthetic process (GO:0045357)3.87613476
62detection of biotic stimulus (GO:0009595)3.85900956
63neuron development (GO:0048666)3.85641746
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.83475979
65receptor guanylyl cyclase signaling pathway (GO:0007168)3.82859672
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.80054345
67response to host (GO:0075136)3.80054345
68response to host defenses (GO:0052200)3.80054345
69* response to light stimulus (GO:0009416)3.78469300
70cellular extravasation (GO:0045123)3.75057547
71regulation of gamma-delta T cell activation (GO:0046643)3.73388710
72response to muramyl dipeptide (GO:0032495)3.72692940
73regulation of short-term neuronal synaptic plasticity (GO:0048172)3.71632385
74detection of molecule of bacterial origin (GO:0032490)3.70805046
75B cell receptor signaling pathway (GO:0050853)3.70292952
76cellular response to interleukin-15 (GO:0071350)3.69227464
77response to pheromone (GO:0019236)3.68215153
78leukocyte migration involved in inflammatory response (GO:0002523)3.61545121
79granulocyte activation (GO:0036230)3.59458790
80retina homeostasis (GO:0001895)3.52453254
81detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.52174209
82negative regulation of leukocyte mediated immunity (GO:0002704)3.50724956
83defense response to protozoan (GO:0042832)3.49569459
84regulation of mast cell degranulation (GO:0043304)3.47885229
85neutrophil mediated immunity (GO:0002446)3.46165449
86myeloid cell activation involved in immune response (GO:0002275)3.44476293
87interferon-gamma-mediated signaling pathway (GO:0060333)3.43959627
88regulation of voltage-gated calcium channel activity (GO:1901385)3.40745844
89cellular response to type I interferon (GO:0071357)3.40132182
90type I interferon signaling pathway (GO:0060337)3.40132182
91negative regulation of phagocytosis (GO:0050765)3.39897304
92negative thymic T cell selection (GO:0045060)3.37674557
93regulation of B cell differentiation (GO:0045577)3.35218413
94retina layer formation (GO:0010842)3.34296539
95response to type I interferon (GO:0034340)3.34133266
96B cell mediated immunity (GO:0019724)3.33679807
97antigen processing and presentation via MHC class Ib (GO:0002475)3.30784781
98positive regulation of mast cell activation (GO:0033005)3.27946753
99NIK/NF-kappaB signaling (GO:0038061)3.27707496
100positive thymic T cell selection (GO:0045059)3.26871031
101negative regulation of T cell mediated immunity (GO:0002710)3.24940326
102regulation of alpha-beta T cell proliferation (GO:0046640)3.22322613
103protein localization to synapse (GO:0035418)3.21153006
104microglial cell activation (GO:0001774)3.19842797
105synaptic vesicle maturation (GO:0016188)3.17977958
106macrophage activation (GO:0042116)3.17342275
107regulation of T cell tolerance induction (GO:0002664)3.16845094
108response to protozoan (GO:0001562)3.16804802
109negative T cell selection (GO:0043383)3.15749483
110regulation of dendritic cell antigen processing and presentation (GO:0002604)3.14073713
111CDP-diacylglycerol biosynthetic process (GO:0016024)3.11889065
112regulation of myeloid leukocyte mediated immunity (GO:0002886)3.11655676
113regulation of mast cell activation involved in immune response (GO:0033006)3.10514937
114regulation of penile erection (GO:0060405)3.10408666
115T cell migration (GO:0072678)3.09392162
116regulation of T-helper 2 cell differentiation (GO:0045628)3.09183369
117germinal center formation (GO:0002467)3.09090663
118post-embryonic morphogenesis (GO:0009886)3.08553835
119phospholipid translocation (GO:0045332)3.08400390
120lipid translocation (GO:0034204)3.08400390
121regulation of leukocyte degranulation (GO:0043300)3.02555087
122tolerance induction (GO:0002507)3.01966406
123positive regulation of B cell differentiation (GO:0045579)3.00654547
124negative regulation of erythrocyte differentiation (GO:0045647)3.00574497
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.99894803
126myeloid leukocyte mediated immunity (GO:0002444)2.97655728
127positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.97237974
128myeloid dendritic cell differentiation (GO:0043011)2.95934356
129positive regulation of neurotransmitter transport (GO:0051590)2.95548644
130CDP-diacylglycerol metabolic process (GO:0046341)2.95466586
131T cell selection (GO:0045058)2.94812699
132positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94300878
133leukocyte degranulation (GO:0043299)2.92983684
134thymic T cell selection (GO:0045061)2.92971273
135regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92659426
136regulation of natural killer cell mediated immunity (GO:0002715)2.92659426
137negative regulation of alpha-beta T cell activation (GO:0046636)2.92319228
138negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.92206700
139regulation of mast cell activation (GO:0033003)2.91535550
140negative regulation of innate immune response (GO:0045824)2.89615728
141regulation of tolerance induction (GO:0002643)2.88693729
142positive regulation of type 2 immune response (GO:0002830)2.88029657
143regulation of gamma-delta T cell differentiation (GO:0045586)2.86413425
144negative regulation of toll-like receptor signaling pathway (GO:0034122)2.85640299
145sodium ion export (GO:0071436)2.84922917
146myeloid dendritic cell activation (GO:0001773)2.84490373
147retinoid metabolic process (GO:0001523)2.84233644
148Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83772237
149B cell homeostasis (GO:0001782)2.77632614
150regulation of regulated secretory pathway (GO:1903305)2.77146072
151positive regulation of vesicle fusion (GO:0031340)2.73943428
152membrane hyperpolarization (GO:0060081)2.73427626
153cellular potassium ion homeostasis (GO:0030007)2.62247263
154response to histamine (GO:0034776)2.62068406
155regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.60374540
156regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.60374540
157* response to radiation (GO:0009314)2.56697359
158diterpenoid metabolic process (GO:0016101)2.56605129
159behavioral response to ethanol (GO:0048149)2.55595351
160synaptic vesicle docking involved in exocytosis (GO:0016081)2.55039797
161positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.51732976
162negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51150079
163dopamine receptor signaling pathway (GO:0007212)2.48407993
164positive regulation of sodium ion transmembrane transport (GO:1902307)2.47553024
165establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.46452483
166mitochondrion transport along microtubule (GO:0047497)2.46452483
167axoneme assembly (GO:0035082)2.45535226
168negative regulation of cation channel activity (GO:2001258)2.45530485
169retinol metabolic process (GO:0042572)2.37571593
170cellular response to abiotic stimulus (GO:0071214)2.36576671
171positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.31920680
172potassium ion export (GO:0071435)2.31647521
173terpenoid metabolic process (GO:0006721)2.30057950
174potassium ion homeostasis (GO:0055075)2.29986081
175protein heterotetramerization (GO:0051290)2.29713274
176short-term memory (GO:0007614)2.29480877
177positive regulation of gastrulation (GO:2000543)2.26602598
178regulation of synaptic vesicle exocytosis (GO:2000300)2.24932532
179vitamin A metabolic process (GO:0006776)2.24805610
180lactate metabolic process (GO:0006089)2.23164012
181arachidonic acid secretion (GO:0050482)2.21824560
182icosanoid secretion (GO:0032309)2.21824560
183synaptic vesicle exocytosis (GO:0016079)2.17585580
184regulation of transcription regulatory region DNA binding (GO:2000677)2.16799842
185positive regulation of cyclase activity (GO:0031281)2.16197126
186negative regulation of calcium ion transmembrane transport (GO:1903170)2.13812880
187negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.13812880
188chemosensory behavior (GO:0007635)2.13791189
189regulation of rhodopsin mediated signaling pathway (GO:0022400)17.1021736
190rhodopsin mediated signaling pathway (GO:0016056)16.7511265
191retinal cone cell development (GO:0046549)14.1317509
192photoreceptor cell development (GO:0042461)12.8386152
193photoreceptor cell maintenance (GO:0045494)12.1192933
194eye photoreceptor cell development (GO:0042462)12.0240109
195retinal rod cell development (GO:0046548)11.0132134
196detection of light stimulus involved in visual perception (GO:0050908)10.4594142
197detection of light stimulus involved in sensory perception (GO:0050962)10.4594142
198GMP metabolic process (GO:0046037)10.3887487
199* phototransduction (GO:0007602)10.1708556
200phototransduction, visible light (GO:0007603)10.0862080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.33802170
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.84121958
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.77105599
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.58762332
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.18876888
6DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.07921154
7MYC_22102868_ChIP-Seq_BL_Human2.98902615
8VDR_21846776_ChIP-Seq_THP-1_Human2.89129571
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.77252092
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.74916053
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.68787847
12KDM2B_26808549_Chip-Seq_DND41_Human2.59890037
13SPI1_23547873_ChIP-Seq_NB4_Human2.43334053
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40847929
15KDM2B_26808549_Chip-Seq_K562_Human2.37347436
16LXR_22292898_ChIP-Seq_THP-1_Human2.33895955
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32278019
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29840722
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.25197432
20SCL_19346495_ChIP-Seq_HPC-7_Human2.22898758
21KDM2B_26808549_Chip-Seq_JURKAT_Human2.22578431
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.22117760
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20248318
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.20083630
25TCF7_22412390_ChIP-Seq_EML_Mouse2.19417571
26* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11538497
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.11465307
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10483807
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02615440
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.00659119
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99682012
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98493482
33P68_20966046_ChIP-Seq_HELA_Human1.96363578
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94359705
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93157532
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92976920
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.91286333
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.89320747
39SPI1_23127762_ChIP-Seq_K562_Human1.86950341
40UTX_26944678_Chip-Seq_JUKART_Human1.84852403
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.81325742
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81128412
43CREB1_26743006_Chip-Seq_LNCaP_Human1.78256175
44CIITA_25753668_ChIP-Seq_RAJI_Human1.78201169
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76724716
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76340767
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75866601
48MYB_26560356_Chip-Seq_TH2_Human1.75342097
49CTCF_27219007_Chip-Seq_Bcells_Human1.74790185
50* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71352780
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66674408
52* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.66359176
53* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.66060367
54MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.64074897
55* SMC4_20622854_ChIP-Seq_HELA_Human1.62841835
56MYB_26560356_Chip-Seq_TH1_Human1.60905292
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53878890
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52302550
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51783223
60PU.1_20513432_ChIP-Seq_Bcells_Mouse1.50435148
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.48593288
62SA1_27219007_Chip-Seq_Bcells_Human1.48309218
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47566614
64* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47238923
65* BCL6_27268052_Chip-Seq_Bcells_Human1.46662956
66* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43051761
67RUNX_20019798_ChIP-Seq_JUKART_Human1.42911168
68* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41537056
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41221741
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39375790
71* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39324111
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39215751
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.38717453
74CTCF_20526341_ChIP-Seq_ESCs_Human1.38199203
75EGR1_19032775_ChIP-ChIP_M12_Human1.37765525
76E2F1_20622854_ChIP-Seq_HELA_Human1.36212479
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.35271910
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35105877
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34793435
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33430254
81VDR_24763502_ChIP-Seq_THP-1_Human1.31932763
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31861320
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30447985
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29935439
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29348676
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.29138539
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28344138
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.27070691
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25485562
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25464862
91MAF_26560356_Chip-Seq_TH1_Human1.25325526
92TAF2_19829295_ChIP-Seq_ESCs_Human1.24819873
93BCOR_27268052_Chip-Seq_Bcells_Human1.23982186
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23886838
95SMAD4_21741376_ChIP-Seq_ESCs_Human1.23251114
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.22643607
97PHF8_20622854_ChIP-Seq_HELA_Human1.22568749
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22014333
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21516176
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20039578
101LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19882792
102HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19573991
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19489068
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19202256
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18343721
106TET1_21451524_ChIP-Seq_MESCs_Mouse1.18112494
107CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16915690
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16491584
109DROSHA_22980978_ChIP-Seq_HELA_Human1.15241817
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14767186
111YY1_22570637_ChIP-Seq_MALME-3M_Human1.14649524
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14610913
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11983933
114EZH2_27294783_Chip-Seq_ESCs_Mouse1.11591877
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10488511
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10118401
117OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09271877
118SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.08672951
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08237592
120* GATA3_27048872_Chip-Seq_THYMUS_Human1.08158660
121ELK3_25401928_ChIP-Seq_HUVEC_Human1.07425020
122REST_21632747_ChIP-Seq_MESCs_Mouse1.07273078
123RACK7_27058665_Chip-Seq_MCF-7_Human1.06417941
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04185528
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02945939
126RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02246269
127TP63_19390658_ChIP-ChIP_HaCaT_Human1.02218355
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00991178
129* MAF_26560356_Chip-Seq_TH2_Human1.00666233
130* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00222136
131SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00051442
132P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99413600
133* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99388836
134DPY_21335234_ChIP-Seq_ESCs_Mouse0.98554682
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98442058
136CTCF_26484167_Chip-Seq_Bcells_Mouse0.97920507
137NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.96661724
138ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96634180
139* OCT4_19829295_ChIP-Seq_ESCs_Human0.96581117
140HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95837736
141* RUNX1_22412390_ChIP-Seq_EML_Mouse0.95397094
142ZNF263_19887448_ChIP-Seq_K562_Human0.94776802
143HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94522675
144* PU_27001747_Chip-Seq_BMDM_Mouse0.94509132
145E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94441099
146CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94164808
147YY1_21170310_ChIP-Seq_MESCs_Mouse0.93936367
148* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.93271939
149UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91928608
150* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91832583
151PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91648594
152WDR5_24793694_ChIP-Seq_LNCAP_Human0.90846968
153FOXP1_21924763_ChIP-Seq_HESCs_Human0.90761251
154SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87589005
155P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85897840
156NCOR1_26117541_ChIP-Seq_K562_Human0.85667770
157SMAD3_21741376_ChIP-Seq_HESCs_Human0.85375448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.11609797
2MP0005253_abnormal_eye_physiology6.87289044
3MP0006072_abnormal_retinal_apoptosis6.81717697
4MP0003724_increased_susceptibility_to4.09402383
5* MP0005195_abnormal_posterior_eye3.80860669
6MP0005671_abnormal_response_to3.73799269
7MP0008260_abnormal_autophagy3.52519341
8MP0005391_vision/eye_phenotype3.49252135
9* MP0001324_abnormal_eye_pigmentation3.30719412
10MP0001800_abnormal_humoral_immune3.18671353
11MP0000685_abnormal_immune_system3.13421813
12MP0005387_immune_system_phenotype3.04216813
13MP0001790_abnormal_immune_system3.04216813
14MP0005000_abnormal_immune_tolerance2.98475855
15MP0002638_abnormal_pupillary_reflex2.95415288
16MP0002419_abnormal_innate_immunity2.93109936
17MP0003950_abnormal_plasma_membrane2.84559958
18MP0005025_abnormal_response_to2.82311554
19MP0002090_abnormal_vision2.82275850
20MP0009785_altered_susceptibility_to2.74074533
21MP0002723_abnormal_immune_serum2.70885629
22MP0002452_abnormal_antigen_presenting2.62297573
23MP0002420_abnormal_adaptive_immunity2.60974060
24MP0001819_abnormal_immune_cell2.59824056
25MP0002229_neurodegeneration2.49670088
26MP0005423_abnormal_somatic_nervous2.39079311
27MP0002653_abnormal_ependyma_morphology2.34257805
28MP0005451_abnormal_body_composition2.18806823
29MP0003763_abnormal_thymus_physiology2.17269013
30MP0006082_CNS_inflammation2.07951342
31MP0002398_abnormal_bone_marrow2.04728705
32MP0002148_abnormal_hypersensitivity_rea2.01719884
33MP0000716_abnormal_immune_system2.00828487
34MP0003011_delayed_dark_adaptation11.0004356
35MP0002405_respiratory_system_inflammati1.98902647
36MP0003300_gastrointestinal_ulcer1.95962443
37MP0001986_abnormal_taste_sensitivity1.95401820
38MP0002752_abnormal_somatic_nervous1.90430988
39MP0001533_abnormal_skeleton_physiology1.83217436
40MP0001764_abnormal_homeostasis1.79439742
41MP0010155_abnormal_intestine_physiology1.70537153
42MP0000689_abnormal_spleen_morphology1.68509359
43MP0001873_stomach_inflammation1.68355675
44MP0002722_abnormal_immune_system1.66327657
45MP0001845_abnormal_inflammatory_respons1.65770236
46MP0002132_abnormal_respiratory_system1.62874064
47MP0002429_abnormal_blood_cell1.61361693
48MP0003191_abnormal_cellular_cholesterol1.57755113
49MP0006292_abnormal_olfactory_placode1.51844212
50MP0000703_abnormal_thymus_morphology1.50078754
51MP0004947_skin_inflammation1.45430623
52MP0000858_altered_metastatic_potential1.42793995
53MP0004381_abnormal_hair_follicle1.41989995
54MP0002277_abnormal_respiratory_mucosa1.41690531
55MP0003866_abnormal_defecation1.39825584
56MP0003221_abnormal_cardiomyocyte_apopto1.37635549
57MP0002882_abnormal_neuron_morphology1.37204229
58MP0001502_abnormal_circadian_rhythm1.36372517
59MP0005310_abnormal_salivary_gland1.35976914
60MP0005394_taste/olfaction_phenotype1.27625589
61MP0005499_abnormal_olfactory_system1.27625589
62MP0008469_abnormal_protein_level1.26190450
63MP0004510_myositis1.25568780
64MP0005058_abnormal_lysosome_morphology1.25302082
65MP0008789_abnormal_olfactory_epithelium1.23289541
66MP0005197_abnormal_uvea_morphology1.13864153
67MP0009764_decreased_sensitivity_to1.12690035
68MP0000490_abnormal_crypts_of1.03840057
69MP0000465_gastrointestinal_hemorrhage1.03546813
70MP0004885_abnormal_endolymph1.02281014
71MP0001851_eye_inflammation0.99289213
72MP0004233_abnormal_muscle_weight0.96055326
73MP0005075_abnormal_melanosome_morpholog0.95035650
74MP0004019_abnormal_vitamin_homeostasis0.93800336
75MP0002254_reproductive_system_inflammat0.92805605
76MP0004883_abnormal_blood_vessel0.89390312
77MP0003828_pulmonary_edema0.88559469
78MP0002166_altered_tumor_susceptibility0.86815175
79MP0004858_abnormal_nervous_system0.86400461
80MP0010030_abnormal_orbit_morphology0.85040297
81MP0001984_abnormal_olfaction0.84336033
82MP0002998_abnormal_bone_remodeling0.83162355
83MP0001663_abnormal_digestive_system0.79872080
84MP0006035_abnormal_mitochondrial_morpho0.79841548
85MP0003634_abnormal_glial_cell0.78107752
86MP0008874_decreased_physiological_sensi0.76529192
87MP0002396_abnormal_hematopoietic_system0.74604003
88MP0003690_abnormal_glial_cell0.74511557
89MP0005166_decreased_susceptibility_to0.74103334
90MP0009763_increased_sensitivity_to0.74094356
91MP0009765_abnormal_xenobiotic_induced0.73979723
92MP0005397_hematopoietic_system_phenotyp0.73116793
93MP0001545_abnormal_hematopoietic_system0.73116793
94MP0003787_abnormal_imprinting0.72561121
95MP0000604_amyloidosis0.72560374
96MP0005390_skeleton_phenotype0.70977230
97MP0005076_abnormal_cell_differentiation0.69147652
98MP0002127_abnormal_cardiovascular_syste0.68069652
99MP0003329_amyloid_beta_deposits0.66836624
100MP0001286_abnormal_eye_development0.65575483
101MP0003878_abnormal_ear_physiology0.63251182
102MP0005377_hearing/vestibular/ear_phenot0.63251182
103MP0005187_abnormal_penis_morphology0.61676495
104MP0002697_abnormal_eye_size0.61409468
105MP0001853_heart_inflammation0.61288934
106MP0002138_abnormal_hepatobiliary_system0.58810825
107MP0004782_abnormal_surfactant_physiolog0.58663951
108MP0000343_altered_response_to0.57543925
109MP0002019_abnormal_tumor_incidence0.57403279
110MP0001293_anophthalmia0.56243678
111MP0002933_joint_inflammation0.54979084
112MP0003448_altered_tumor_morphology0.54949877
113MP0003303_peritoneal_inflammation0.54425838
114MP0000313_abnormal_cell_death0.52836248
115MP0001849_ear_inflammation0.51829632
116MP0000015_abnormal_ear_pigmentation0.51500153
117MP0000750_abnormal_muscle_regeneration0.51301571
118MP0001915_intracranial_hemorrhage0.50149354
119MP0002234_abnormal_pharynx_morphology0.49925885
120MP0005248_abnormal_Harderian_gland0.48333353
121MP0002272_abnormal_nervous_system0.47843391
122MP0001486_abnormal_startle_reflex0.47458299
123MP0002332_abnormal_exercise_endurance0.47402588
124MP0005193_abnormal_anterior_eye0.46164842
125MP0004859_abnormal_synaptic_plasticity0.46152491
126MP0003880_abnormal_central_pattern0.44241451
127MP0000631_abnormal_neuroendocrine_gland0.42603336
128MP0002909_abnormal_adrenal_gland0.40989407
129MP0003635_abnormal_synaptic_transmissio0.39608148
130MP0002064_seizures0.36797941
131MP0004270_analgesia0.36484250
132MP0002102_abnormal_ear_morphology0.36268455
133MP0001968_abnormal_touch/_nociception0.36079791
134MP0000569_abnormal_digit_pigmentation0.35481117
135MP0003172_abnormal_lysosome_physiology0.34688090
136MP0002067_abnormal_sensory_capabilities0.32050001
137MP0002092_abnormal_eye_morphology0.30829881
138MP0008961_abnormal_basal_metabolism0.30685312
139MP0004811_abnormal_neuron_physiology0.30641492
140MP0001963_abnormal_hearing_physiology0.29531422
141MP0002089_abnormal_postnatal_growth/wei0.29506383
142MP0009046_muscle_twitch0.29207399
143MP0002184_abnormal_innervation0.27519905
144MP0002734_abnormal_mechanical_nocicepti0.27194049
145MP0009278_abnormal_bone_marrow0.26817759
146MP0002152_abnormal_brain_morphology0.26588820
147MP0008995_early_reproductive_senescence0.26485872
148MP0005595_abnormal_vascular_smooth0.25715020
149MP0003436_decreased_susceptibility_to0.25537236
150MP0005376_homeostasis/metabolism_phenot0.24951438
151MP0003638_abnormal_response/metabolism_0.24842285
152MP0002877_abnormal_melanocyte_morpholog0.24586851
153MP0003890_abnormal_embryonic-extraembry0.24047654
154MP0003183_abnormal_peptide_metabolism0.22628540
155MP0009780_abnormal_chondrocyte_physiolo0.21343721
156MP0002063_abnormal_learning/memory/cond0.20299514
157MP0010386_abnormal_urinary_bladder0.19100540
158MP0008569_lethality_at_weaning0.18858431
159MP0002928_abnormal_bile_duct0.18282446
160MP0003075_altered_response_to0.18208804
161MP0004130_abnormal_muscle_cell0.16984495
162MP0005464_abnormal_platelet_physiology0.16800234
163MP0008007_abnormal_cellular_replicative0.16627549
164MP0008004_abnormal_stomach_pH0.16508641
165MP0003943_abnormal_hepatobiliary_system0.16366651
166MP0001835_abnormal_antigen_presentation0.16140183
167MP0009333_abnormal_splenocyte_physiolog0.15665799
168MP0003861_abnormal_nervous_system0.15402167
169MP0004808_abnormal_hematopoietic_stem0.14405996
170MP0005386_behavior/neurological_phenoty0.14273893
171MP0004924_abnormal_behavior0.14273893
172MP0001270_distended_abdomen0.14144294
173MP0001614_abnormal_blood_vessel0.14008212
174MP0003045_fibrosis0.13857142
175MP0002572_abnormal_emotion/affect_behav0.13732605
176MP0002066_abnormal_motor_capabilities/c0.11818482
177MP0000428_abnormal_craniofacial_morphol0.11638949
178MP0000778_abnormal_nervous_system0.11558846
179MP0003633_abnormal_nervous_system0.11489171

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)8.86547017
2Pigmentary retinal degeneration (HP:0001146)8.85701926
3Pendular nystagmus (HP:0012043)8.59010984
4Central scotoma (HP:0000603)8.49124518
5Abolished electroretinogram (ERG) (HP:0000550)7.62463104
6Scotoma (HP:0000575)7.38789484
7Abnormality of macular pigmentation (HP:0008002)7.33568081
8Dyschromatopsia (HP:0007641)7.06304012
9Attenuation of retinal blood vessels (HP:0007843)6.77377519
10Eczematoid dermatitis (HP:0000976)6.73141578
11Decreased central vision (HP:0007663)6.08721370
12Recurrent bacterial skin infections (HP:0005406)5.84758474
13Posterior subcapsular cataract (HP:0007787)5.79992637
14Recurrent abscess formation (HP:0002722)5.72960678
15Type II diabetes mellitus (HP:0005978)5.64351274
16Abnormality of macrophages (HP:0004311)5.54424550
17Severe visual impairment (HP:0001141)5.50588580
18* Photophobia (HP:0000613)5.27029834
19Macular degeneration (HP:0000608)5.24239687
20Increased corneal curvature (HP:0100692)5.23907434
21Keratoconus (HP:0000563)5.23907434
22Mediastinal lymphadenopathy (HP:0100721)4.94100357
23Myositis (HP:0100614)4.91053055
24Vitreoretinal degeneration (HP:0000655)4.90897709
25Cone-rod dystrophy (HP:0000548)4.81550030
26Constricted visual fields (HP:0001133)4.73871278
27Stomatitis (HP:0010280)4.69684327
28Obstructive lung disease (HP:0006536)4.53685310
29Chronic obstructive pulmonary disease (HP:0006510)4.53685310
30Orchitis (HP:0100796)4.53050418
31Gastrointestinal infarctions (HP:0005244)4.43992001
32Recurrent gram-negative bacterial infections (HP:0005420)4.36811851
33Meningitis (HP:0001287)4.36490018
34Elevated erythrocyte sedimentation rate (HP:0003565)4.33427137
35Optic neuritis (HP:0100653)4.28467236
36Retrobulbar optic neuritis (HP:0100654)4.28467236
37Recurrent fungal infections (HP:0002841)4.20756336
38Retinitis pigmentosa (HP:0000510)4.12522013
39Choroideremia (HP:0001139)3.92682425
40Vasculitis (HP:0002633)3.86848531
41Recurrent skin infections (HP:0001581)3.77586986
42Urticaria (HP:0001025)3.67756631
43Recurrent cutaneous fungal infections (HP:0011370)3.62544929
44Chronic mucocutaneous candidiasis (HP:0002728)3.62544929
45Decreased electroretinogram (ERG) amplitude (HP:0000654)3.56040506
46Increased IgM level (HP:0003496)3.55717505
47Cellulitis (HP:0100658)3.48195122
48Chest pain (HP:0100749)3.46388580
49Abnormal delayed hypersensitivity skin test (HP:0002963)3.46133689
50Increased IgE level (HP:0003212)3.45778282
51Encephalitis (HP:0002383)3.43388221
52Gingivitis (HP:0000230)3.39681514
53Subcapsular cataract (HP:0000523)3.37990312
54Progressive visual loss (HP:0000529)3.33237804
55Gastrointestinal stroma tumor (HP:0100723)3.30929128
56* Lymphopenia (HP:0001888)3.19878598
57Recurrent viral infections (HP:0004429)2.97146721
58Keratoconjunctivitis sicca (HP:0001097)2.92335893
59* Abnormality of cells of the lymphoid lineage (HP:0012140)2.89267394
60IgM deficiency (HP:0002850)2.86643685
61Pulmonary infiltrates (HP:0002113)2.85475319
62Panhypogammaglobulinemia (HP:0003139)2.84680412
63Hemoptysis (HP:0002105)2.83343807
64Gastrointestinal inflammation (HP:0004386)2.82693937
65Hypochromic microcytic anemia (HP:0004840)2.79093869
66Inflammation of the large intestine (HP:0002037)2.71056622
67Hypochromic anemia (HP:0001931)2.70628980
68Keratoconjunctivitis (HP:0001096)2.68090252
69Agammaglobulinemia (HP:0004432)2.63867485
70Wide nasal bridge (HP:0000431)2.60168906
71Episodic fever (HP:0001954)2.57341609
72Retinal atrophy (HP:0001105)2.56212440
73Sepsis (HP:0100806)2.55091178
74Anorexia (HP:0002039)2.53431369
75Colitis (HP:0002583)2.48595982
76Spontaneous hematomas (HP:0007420)2.48474353
77Restrictive lung disease (HP:0002091)2.43702035
78T lymphocytopenia (HP:0005403)2.42619653
79Osteomyelitis (HP:0002754)2.41872210
80Arterial thrombosis (HP:0004420)2.40631358
81Leukocytosis (HP:0001974)2.35916779
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.34748081
83Pustule (HP:0200039)2.34303746
84Optic disc pallor (HP:0000543)2.33500495
85Abnormality of T cells (HP:0002843)2.33243653
86Premature loss of primary teeth (HP:0006323)2.32442776
87Amyloidosis (HP:0011034)2.32408241
88Hypergammaglobulinemia (HP:0010702)2.31508455
89Hepatosplenomegaly (HP:0001433)2.29490229
90Abnormality of the pleura (HP:0002103)2.27310029
91Petechiae (HP:0000967)2.26713377
92Recurrent pneumonia (HP:0006532)2.20428136
93Abnormality of T cell number (HP:0011839)2.17110473
94Pulmonary embolism (HP:0002204)2.16254731
95Amaurosis fugax (HP:0100576)2.15777255
96Prolonged bleeding time (HP:0003010)2.15172232
97Peripheral hypomyelination (HP:0007182)2.12534038
98Peritonitis (HP:0002586)2.11548813
99Abnormality of the peritoneum (HP:0002585)2.09846499
100Acute hepatic failure (HP:0006554)2.09007133
101Loss of speech (HP:0002371)2.08864944
102Neuronal loss in central nervous system (HP:0002529)2.08542173
103Papilloma (HP:0012740)2.05056624
104Verrucae (HP:0200043)2.05056624
105Keratitis (HP:0000491)2.04458282
106Hypertensive crisis (HP:0100735)2.03705289
107Recurrent lower respiratory tract infections (HP:0002783)2.02993997
108Gangrene (HP:0100758)2.02018297
109Hypermelanotic macule (HP:0001034)2.01331856
110Abnormality of T cell physiology (HP:0011840)2.00509363
111Congenital stationary night blindness (HP:0007642)13.7109451
112Absent rod-and cone-mediated responses on ERG (HP:0007688)11.1869625
113Bony spicule pigmentary retinopathy (HP:0007737)11.1061514
114Abnormal rod and cone electroretinograms (HP:0008323)10.4665961
115Granulocytopenia (HP:0001913)1.99536574
116Papilledema (HP:0001085)1.99387237
117Emphysema (HP:0002097)1.98051773
118Gingival bleeding (HP:0000225)1.98020503
119Skin rash (HP:0000988)1.97302697
120Epistaxis (HP:0000421)1.94887617
121* Recurrent sinusitis (HP:0011108)1.94226867
122Skin ulcer (HP:0200042)1.92966390
123Glomerulopathy (HP:0100820)1.92894309
124IgG deficiency (HP:0004315)1.91348002
125Viral hepatitis (HP:0006562)1.90488386
126Gait imbalance (HP:0002141)1.89968529
127Polar cataract (HP:0010696)1.88206263
128Ankle clonus (HP:0011448)1.87403970
129Congenital primary aphakia (HP:0007707)1.87173244
130Arthralgia (HP:0002829)1.85160698
131Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.84636272
132Purpura (HP:0000979)1.83864430
133Microcytic anemia (HP:0001935)1.80769303
134Congenital sensorineural hearing impairment (HP:0008527)1.71822002
135Optic atrophy (HP:0000648)1.63891084
136Nephrogenic diabetes insipidus (HP:0009806)1.62356536
137Medial flaring of the eyebrow (HP:0010747)1.49903188
138Horizontal nystagmus (HP:0000666)1.43925883
139True hermaphroditism (HP:0010459)1.40933472
140Vaginal atresia (HP:0000148)1.31948863
141Poor coordination (HP:0002370)1.31916248
142Severe Myopia (HP:0011003)1.28150023
143Genital tract atresia (HP:0001827)1.24284798
144Visual hallucinations (HP:0002367)1.16449558
145Pancreatic fibrosis (HP:0100732)1.16405068
146Abnormality of the fovea (HP:0000493)1.15633687
147Sclerocornea (HP:0000647)1.15624755
148Increased neuronal autofluorescent lipopigment (HP:0002074)1.14531550
149Albinism (HP:0001022)1.14060880
150Increased cerebral lipofuscin (HP:0011813)1.13402849
151Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.11464977
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.08209398
153Aplasia/Hypoplasia of the lens (HP:0008063)1.08167482
154Insomnia (HP:0100785)1.07212995
155Aplasia/Hypoplasia of the fovea (HP:0008060)1.06183622
156Hypoplasia of the fovea (HP:0007750)1.06183622
157Cystic liver disease (HP:0006706)1.04745962
158Retinal detachment (HP:0000541)1.01814280
159Hypermetropia (HP:0000540)1.01154793
160Aplasia/Hypoplasia of the macula (HP:0008059)1.00613023
161Epileptic encephalopathy (HP:0200134)0.96791844
162Chorioretinal coloboma (HP:0000567)0.96452321
163Pancreatic cysts (HP:0001737)0.94648842
164Anophthalmia (HP:0000528)0.92895720
165Abnormal gallbladder physiology (HP:0012438)0.92343677
166Cholecystitis (HP:0001082)0.92343677
167Abnormality of the lower motor neuron (HP:0002366)0.92078673
168Aplasia/Hypoplasia affecting the retina (HP:0008061)0.91814107
169Dysdiadochokinesis (HP:0002075)0.91383084
170Hypoventilation (HP:0002791)0.90743843
171Hyperacusis (HP:0010780)0.89502230
172Cerebellar dysplasia (HP:0007033)0.87062978
173Abdominal situs inversus (HP:0003363)0.86384638
174Abnormality of abdominal situs (HP:0011620)0.86384638
175Supranuclear gaze palsy (HP:0000605)0.85471770
176Decreased testicular size (HP:0008734)0.82115345
177Depression (HP:0000716)0.81687422
178Truncal ataxia (HP:0002078)0.81524256
179Astigmatism (HP:0000483)0.79469037
180Furrowed tongue (HP:0000221)0.78289001
181Elfin facies (HP:0004428)0.78270001
182Left ventricular hypertrophy (HP:0001712)0.76492612
183Macroorchidism (HP:0000053)0.76228140
184Specific learning disability (HP:0001328)0.74762645
185Febrile seizures (HP:0002373)0.74466476
186Hand muscle atrophy (HP:0009130)0.73728558
187Asthma (HP:0002099)0.72291096
188Heterotopia (HP:0002282)0.69889293
189Broad foot (HP:0001769)0.69542963
190Renovascular hypertension (HP:0100817)0.66476976
191Septo-optic dysplasia (HP:0100842)0.66221910
192Molar tooth sign on MRI (HP:0002419)0.65600479
193Abnormality of midbrain morphology (HP:0002418)0.65600479
194Anencephaly (HP:0002323)0.65434312
195Abnormality of the fingertips (HP:0001211)0.65021780
196Progressive cerebellar ataxia (HP:0002073)0.63283065
197Pallor (HP:0000980)0.60086161
198Inappropriate behavior (HP:0000719)0.59823689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK19.62356676
2RIPK44.62381012
3MAP3K103.68299664
4PBK3.34755878
5IRAK43.02416802
6IRAK22.92637577
7PRPF4B2.80136564
8PINK12.47437193
9SIK22.40843572
10PKN22.39885420
11SCYL22.33713241
12MAP2K32.30931190
13TYK22.28986241
14SIK32.28212091
15CSK2.13468969
16GRK62.11547702
17TRIB31.98378007
18SMG11.98089715
19EPHB11.93412649
20CDK121.89093913
21TAOK11.88436949
22FGR1.74571855
23HIPK21.69370905
24MAP3K111.67573130
25ICK1.67189979
26CAMK1G1.58180104
27PAK61.55582898
28CAMK1D1.53389602
29RPS6KA41.51903486
30MAP4K11.51776658
31TESK21.50752478
32HCK1.47947444
33JAK31.46252851
34ZAP701.43086514
35NEK21.40549854
36MAP3K141.34195779
37NEK11.33322643
38TBK11.28695858
39FES1.26254464
40IKBKE1.25297755
41MARK21.22468781
42LYN1.22258685
43JAK21.19928404
44ADRBK11.18195054
45EEF2K1.15494161
46MATK1.12993275
47CSF1R1.09669515
48ERBB21.05251949
49MAP3K31.05236425
50TXK1.03952717
51TAOK31.03566972
52MAP3K11.03471062
53ALK1.02997138
54BRD41.00185543
55CAMKK10.98049698
56LRRK20.96493616
57PRKD30.95425446
58MAP3K130.93438631
59FGFR40.93273269
60PRKCH0.91276327
61LCK0.91095773
62MAPK120.91054598
63JAK10.89116613
64YES10.88460951
65MARK10.87216617
66DYRK1B0.85633802
67CDK90.83102024
68TGFBR10.82356248
69PRKCZ0.80386090
70ITK0.78476870
71EPHA30.78222247
72BCKDK0.78139413
73MAP3K40.76497589
74IRAK10.75079647
75CCNB10.75050183
76TNK20.74548490
77RET0.73644350
78TESK10.73242904
79CSNK1D0.70721050
80IKBKB0.70629052
81BMPR20.70001593
82ARAF0.68831595
83MAP3K50.65764046
84MAPK70.65729385
85ERN10.65580735
86DYRK1A0.64386891
87MINK10.63259736
88PDPK10.62276778
89MARK30.62230351
90BLK0.62109813
91PNCK0.60982053
92RPS6KA20.59689553
93RIPK10.58941793
94PASK0.58602534
95SGK4940.56951536
96SGK2230.56951536
97PRKCB0.56294895
98STK380.55810904
99PRKACG0.51585286
100GRK50.51386090
101BTK0.51318409
102SIK10.50235626
103PTK60.49073625
104KIT0.48570027
105MAPK90.46889175
106CAMK10.46289419
107MAP3K90.44440226
108PRKCQ0.44404306
109RPS6KL10.43490863
110RPS6KC10.43490863
111PRKAA10.42967936
112DYRK30.42636517
113KSR10.42308257
114RPS6KB20.41767410
115MAPK140.41550086
116CDC42BPA0.40641462
117MAP2K60.40022487
118KSR20.39559462
119RPS6KA30.39234178
120PRKD20.38764406
121STK100.38000757
122MAP3K70.37766636
123PIM10.37747275
124RPS6KB10.37370359
125DYRK20.37006812
126GSK3B0.36456834
127CDK40.36324743
128ERBB30.36291178
129PRKDC0.36148945
130SYK0.35656198
131AKT20.34858805
132CDK30.34712962
133MAP2K40.34383723
134SGK30.33826869
135CDK70.33801005
136UHMK10.33362168
137STK110.31970832
138CAMK40.31803284
139CAMKK20.31746656
140RAF10.31434983
141TLK10.30428483
142PRKCD0.30186993
143CDK10.30147182
144MAPK30.29192041
145FGFR10.29037425
146CDK190.28513897
147CDK50.28159278
148TAOK20.27766363
149PDK10.26569321
150MAP2K70.25808976
151FGFR30.24600201
152TGFBR20.24574016
153MAP3K60.23493243
154ILK0.22913553
155FYN0.22108011
156PRKD10.21950729
157CDK20.21910224
158MAPK100.21773631
159CDK11A0.21739217

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.11079747
2Graft-versus-host disease_Homo sapiens_hsa053323.00711784
3Autoimmune thyroid disease_Homo sapiens_hsa053202.76700066
4Primary immunodeficiency_Homo sapiens_hsa053402.58821963
5Type I diabetes mellitus_Homo sapiens_hsa049402.32712846
6Staphylococcus aureus infection_Homo sapiens_hsa051502.29204768
7Viral myocarditis_Homo sapiens_hsa054162.07649824
8Phototransduction_Homo sapiens_hsa0474415.2824062
9Antigen processing and presentation_Homo sapiens_hsa046121.98283365
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93412324
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.93284551
12Synaptic vesicle cycle_Homo sapiens_hsa047211.86858280
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84483051
14Asthma_Homo sapiens_hsa053101.79691332
15T cell receptor signaling pathway_Homo sapiens_hsa046601.65214813
16Measles_Homo sapiens_hsa051621.57654338
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56433469
18Phagosome_Homo sapiens_hsa041451.55817385
19Herpes simplex infection_Homo sapiens_hsa051681.53340709
20Toxoplasmosis_Homo sapiens_hsa051451.52659062
21Influenza A_Homo sapiens_hsa051641.52032896
22Olfactory transduction_Homo sapiens_hsa047401.45840334
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43302839
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.42738637
25Hematopoietic cell lineage_Homo sapiens_hsa046401.39435280
26Rheumatoid arthritis_Homo sapiens_hsa053231.30774914
27Shigellosis_Homo sapiens_hsa051311.28789672
28Legionellosis_Homo sapiens_hsa051341.27957608
29Other glycan degradation_Homo sapiens_hsa005111.25013731
30Salmonella infection_Homo sapiens_hsa051321.24522920
31Epstein-Barr virus infection_Homo sapiens_hsa051691.23243438
32GABAergic synapse_Homo sapiens_hsa047271.23206830
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20941441
34Malaria_Homo sapiens_hsa051441.13459629
35Hepatitis B_Homo sapiens_hsa051611.12093529
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11665200
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09117431
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07842622
39TNF signaling pathway_Homo sapiens_hsa046680.97303401
40Cholinergic synapse_Homo sapiens_hsa047250.96808905
41Regulation of autophagy_Homo sapiens_hsa041400.96568205
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90614365
43Apoptosis_Homo sapiens_hsa042100.90261585
44Hepatitis C_Homo sapiens_hsa051600.89292573
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.87667835
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.85921542
47Pancreatic cancer_Homo sapiens_hsa052120.84979357
48Circadian entrainment_Homo sapiens_hsa047130.83839772
49Viral carcinogenesis_Homo sapiens_hsa052030.83044537
50African trypanosomiasis_Homo sapiens_hsa051430.82503073
51Morphine addiction_Homo sapiens_hsa050320.82348996
52Dopaminergic synapse_Homo sapiens_hsa047280.82322581
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81085336
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80682392
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79996217
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.78033248
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74699450
58mTOR signaling pathway_Homo sapiens_hsa041500.73486103
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.73294686
60HTLV-I infection_Homo sapiens_hsa051660.72546304
61Glutamatergic synapse_Homo sapiens_hsa047240.71704431
62Prolactin signaling pathway_Homo sapiens_hsa049170.71459242
63Collecting duct acid secretion_Homo sapiens_hsa049660.68987269
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68012843
65Circadian rhythm_Homo sapiens_hsa047100.66184930
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65107778
67Fructose and mannose metabolism_Homo sapiens_hsa000510.61795939
68Vibrio cholerae infection_Homo sapiens_hsa051100.59685093
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58116701
70Serotonergic synapse_Homo sapiens_hsa047260.57975775
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56922104
72Systemic lupus erythematosus_Homo sapiens_hsa053220.56559696
73Pertussis_Homo sapiens_hsa051330.56363364
74Retinol metabolism_Homo sapiens_hsa008300.55532553
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55098751
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54665572
77Choline metabolism in cancer_Homo sapiens_hsa052310.54107466
78HIF-1 signaling pathway_Homo sapiens_hsa040660.49249060
79Insulin secretion_Homo sapiens_hsa049110.48916551
80Galactose metabolism_Homo sapiens_hsa000520.48625501
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48571219
82ErbB signaling pathway_Homo sapiens_hsa040120.47100169
83Oxytocin signaling pathway_Homo sapiens_hsa049210.46349389
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46101624
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46053104
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44301623
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43940356
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43389558
89Chemokine signaling pathway_Homo sapiens_hsa040620.42748714
90Inositol phosphate metabolism_Homo sapiens_hsa005620.42010556
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41359864
92mRNA surveillance pathway_Homo sapiens_hsa030150.41028540
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.39440628
94ABC transporters_Homo sapiens_hsa020100.39346706
95Alcoholism_Homo sapiens_hsa050340.39261528
96Notch signaling pathway_Homo sapiens_hsa043300.37677589
97cAMP signaling pathway_Homo sapiens_hsa040240.37440415
98FoxO signaling pathway_Homo sapiens_hsa040680.35497757
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34852992
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34842043
101Nitrogen metabolism_Homo sapiens_hsa009100.34580644
102Purine metabolism_Homo sapiens_hsa002300.34320564
103Renin secretion_Homo sapiens_hsa049240.34167501
104Non-small cell lung cancer_Homo sapiens_hsa052230.33944385
105Rap1 signaling pathway_Homo sapiens_hsa040150.33704113
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33349375
107Chronic myeloid leukemia_Homo sapiens_hsa052200.31686557
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31655761
109N-Glycan biosynthesis_Homo sapiens_hsa005100.31469628
110AMPK signaling pathway_Homo sapiens_hsa041520.31020525
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.30749434
112B cell receptor signaling pathway_Homo sapiens_hsa046620.30428080
113Glucagon signaling pathway_Homo sapiens_hsa049220.29637508
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29432260
115VEGF signaling pathway_Homo sapiens_hsa043700.29376308
116Nicotine addiction_Homo sapiens_hsa050330.28877619
117Type II diabetes mellitus_Homo sapiens_hsa049300.28050184
118Salivary secretion_Homo sapiens_hsa049700.27390393
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27216040
120Long-term potentiation_Homo sapiens_hsa047200.26939520
121Gastric acid secretion_Homo sapiens_hsa049710.26368581
122Colorectal cancer_Homo sapiens_hsa052100.26057111
123Acute myeloid leukemia_Homo sapiens_hsa052210.25850644
124Endometrial cancer_Homo sapiens_hsa052130.25715196
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.25171883
126Cardiac muscle contraction_Homo sapiens_hsa042600.24786982
127Glioma_Homo sapiens_hsa052140.24312372
128Lysosome_Homo sapiens_hsa041420.23522754
129Insulin signaling pathway_Homo sapiens_hsa049100.23357471
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23074442
131Spliceosome_Homo sapiens_hsa030400.22860867
132GnRH signaling pathway_Homo sapiens_hsa049120.22152842
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21433170
134Renal cell carcinoma_Homo sapiens_hsa052110.21343027
135Biosynthesis of amino acids_Homo sapiens_hsa012300.21211697
136Insulin resistance_Homo sapiens_hsa049310.20222419
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20050763
138Cocaine addiction_Homo sapiens_hsa050300.19060801
139Platelet activation_Homo sapiens_hsa046110.18924033
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18556634
141Lysine degradation_Homo sapiens_hsa003100.18525723
142Oocyte meiosis_Homo sapiens_hsa041140.18390722
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.18142852
144Dilated cardiomyopathy_Homo sapiens_hsa054140.17921851
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17718145
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.17670636
147Pentose phosphate pathway_Homo sapiens_hsa000300.17654915
148Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17626186
149MAPK signaling pathway_Homo sapiens_hsa040100.17196453
150Endocytosis_Homo sapiens_hsa041440.15405954
151Osteoclast differentiation_Homo sapiens_hsa043800.15297929
152Glycerolipid metabolism_Homo sapiens_hsa005610.14193323
153Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.14141530
154Estrogen signaling pathway_Homo sapiens_hsa049150.13775162
155Tuberculosis_Homo sapiens_hsa051520.13218667
156Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11833099
157RNA degradation_Homo sapiens_hsa030180.11345452
158AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.11036567
159Leishmaniasis_Homo sapiens_hsa051400.10055080
160Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.09987609

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