UNC13A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.30601233
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.07516937
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.00101121
4* regulation of short-term neuronal synaptic plasticity (GO:0048172)5.98952861
5* synaptic vesicle maturation (GO:0016188)5.81945056
6vocalization behavior (GO:0071625)5.67922398
7synaptic vesicle exocytosis (GO:0016079)5.52634353
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.42711994
9glutamate secretion (GO:0014047)5.39426154
10regulation of synaptic vesicle exocytosis (GO:2000300)5.20912942
11regulation of glutamate receptor signaling pathway (GO:1900449)5.10147561
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.86781163
13protein localization to synapse (GO:0035418)4.86680238
14exploration behavior (GO:0035640)4.80015755
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.70917195
16regulation of synaptic vesicle transport (GO:1902803)4.62304229
17layer formation in cerebral cortex (GO:0021819)4.62131426
18* regulation of neuronal synaptic plasticity (GO:0048168)4.59498877
19regulation of synapse structural plasticity (GO:0051823)4.57260992
20cerebellar granule cell differentiation (GO:0021707)4.55033368
21neuronal action potential propagation (GO:0019227)4.49650752
22* neurotransmitter secretion (GO:0007269)4.45118194
23* synaptic vesicle docking involved in exocytosis (GO:0016081)4.42796861
24dendritic spine morphogenesis (GO:0060997)4.40316206
25neuron cell-cell adhesion (GO:0007158)4.36003594
26regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.27335851
27neurotransmitter-gated ion channel clustering (GO:0072578)4.23076704
28glutamate receptor signaling pathway (GO:0007215)4.20488205
29* synaptic transmission, glutamatergic (GO:0035249)4.19697297
30gamma-aminobutyric acid transport (GO:0015812)4.16545471
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.12331525
32amino acid import (GO:0043090)4.11701239
33long-term memory (GO:0007616)4.10604597
34positive regulation of membrane potential (GO:0045838)4.08148138
35proline transport (GO:0015824)3.99279292
36cellular potassium ion homeostasis (GO:0030007)3.99071342
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.94991361
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93438490
39negative regulation of dendrite morphogenesis (GO:0050774)3.91853957
40* neuron-neuron synaptic transmission (GO:0007270)3.89912442
41potassium ion homeostasis (GO:0055075)3.87393844
42regulation of dendritic spine morphogenesis (GO:0061001)3.83649408
43positive regulation of synapse maturation (GO:0090129)3.83076419
44sodium ion export (GO:0071436)3.78612509
45neuromuscular process controlling balance (GO:0050885)3.77260993
46regulation of postsynaptic membrane potential (GO:0060078)3.76561292
47presynaptic membrane organization (GO:0097090)3.72220121
48presynaptic membrane assembly (GO:0097105)3.72011363
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.70066880
50activation of protein kinase A activity (GO:0034199)3.64688008
51potassium ion import (GO:0010107)3.64129650
52* regulation of synaptic plasticity (GO:0048167)3.63497026
53regulation of voltage-gated calcium channel activity (GO:1901385)3.58021620
54transmission of nerve impulse (GO:0019226)3.55344134
55* neurotransmitter transport (GO:0006836)3.53615017
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.53609125
57auditory behavior (GO:0031223)3.53171385
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.50539683
59neuron recognition (GO:0008038)3.49958704
60dendrite morphogenesis (GO:0048813)3.48228949
61cerebellar Purkinje cell differentiation (GO:0021702)3.48202304
62synaptic vesicle endocytosis (GO:0048488)3.47274637
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.40476731
64neuromuscular synaptic transmission (GO:0007274)3.40040874
65G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.37524605
66* regulation of neurotransmitter secretion (GO:0046928)3.37072765
67prepulse inhibition (GO:0060134)3.36563099
68postsynaptic membrane organization (GO:0001941)3.35429951
69regulation of vesicle fusion (GO:0031338)3.34758100
70glycine transport (GO:0015816)3.31867595
71long-term synaptic potentiation (GO:0060291)3.30205206
72response to auditory stimulus (GO:0010996)3.30024547
73central nervous system myelination (GO:0022010)3.29830317
74axon ensheathment in central nervous system (GO:0032291)3.29830317
75regulation of ARF protein signal transduction (GO:0032012)3.29592361
76neuromuscular process controlling posture (GO:0050884)3.29373026
77cell communication by electrical coupling (GO:0010644)3.28805779
78* regulation of neurotransmitter levels (GO:0001505)3.28470685
79membrane depolarization during action potential (GO:0086010)3.28462347
80neuronal ion channel clustering (GO:0045161)3.27488657
81axonal fasciculation (GO:0007413)3.27076776
82cellular sodium ion homeostasis (GO:0006883)3.26328708
83membrane depolarization (GO:0051899)3.24603872
84positive regulation of dendritic spine development (GO:0060999)3.24413301
85dendritic spine organization (GO:0097061)3.23520126
86positive regulation of dendritic spine morphogenesis (GO:0061003)3.21724869
87membrane hyperpolarization (GO:0060081)3.20989609
88regulation of dendritic spine development (GO:0060998)3.20010933
89vesicle transport along microtubule (GO:0047496)3.17266137
90gamma-aminobutyric acid signaling pathway (GO:0007214)3.16049758
91* regulation of synaptic transmission, glutamatergic (GO:0051966)3.15890007
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15742021
93acidic amino acid transport (GO:0015800)3.12767984
94* regulation of neurotransmitter transport (GO:0051588)3.12251125
95learning (GO:0007612)3.11531763
96neurotransmitter uptake (GO:0001504)3.11510822
97chemosensory behavior (GO:0007635)3.11008910
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10748540
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08667151
100detection of calcium ion (GO:0005513)3.08489931
101neuromuscular process (GO:0050905)3.08401470
102* positive regulation of neurotransmitter transport (GO:0051590)3.07997428
103serotonin metabolic process (GO:0042428)3.06481378
104synapse assembly (GO:0007416)3.05294338
105cell differentiation in hindbrain (GO:0021533)3.04743771
106social behavior (GO:0035176)3.04584811
107intraspecies interaction between organisms (GO:0051703)3.04584811
108negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04559576
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04111814
110establishment of synaptic vesicle localization (GO:0097480)3.03363057
111cell migration in hindbrain (GO:0021535)3.01670355
112behavioral defense response (GO:0002209)2.98711708
113behavioral fear response (GO:0001662)2.98711708
114* regulation of synaptic transmission (GO:0050804)2.98640597
115regulation of calcium ion-dependent exocytosis (GO:0017158)2.96302812
116negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95841869
117L-amino acid import (GO:0043092)2.93782830
118* synaptic transmission (GO:0007268)2.92114910
119regulation of synapse maturation (GO:0090128)2.91709977
120cerebellar Purkinje cell layer development (GO:0021680)2.91114074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.16488549
2GBX2_23144817_ChIP-Seq_PC3_Human3.23270375
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11720187
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07355157
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01216863
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.92656898
7REST_21632747_ChIP-Seq_MESCs_Mouse2.90458705
8* DROSHA_22980978_ChIP-Seq_HELA_Human2.78242880
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76974404
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76974404
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68818306
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58809460
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57152575
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54440624
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.48806797
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46208779
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42947056
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.36545505
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33927696
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.33477788
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26942824
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.24916836
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.22990772
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19961032
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.15181684
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12066499
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11171951
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96462167
29AR_21572438_ChIP-Seq_LNCaP_Human1.76111609
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75251243
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.73083136
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58266715
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54630841
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54447099
35SMAD4_21799915_ChIP-Seq_A2780_Human1.49046619
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43310502
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39791442
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39138169
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.38756305
40ZNF274_21170338_ChIP-Seq_K562_Hela1.38500927
41KDM2B_26808549_Chip-Seq_K562_Human1.36091942
42SOX2_21211035_ChIP-Seq_LN229_Gbm1.30002964
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28179239
44AR_19668381_ChIP-Seq_PC3_Human1.25305445
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25217153
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24194903
47* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22738403
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22713334
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22226598
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22117477
51* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20064146
52RING1B_27294783_Chip-Seq_NPCs_Mouse1.19665125
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.19589681
54TAF15_26573619_Chip-Seq_HEK293_Human1.19333073
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17748609
56STAT3_23295773_ChIP-Seq_U87_Human1.17735891
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15172627
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.15145016
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12705360
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12337933
61AR_25329375_ChIP-Seq_VCAP_Human1.12174735
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12018651
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.10122927
64P300_19829295_ChIP-Seq_ESCs_Human1.07686500
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07168006
66YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05965413
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05211115
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04516742
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03486739
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02940185
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02592078
72* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02290598
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02089378
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99918855
75* TCF4_23295773_ChIP-Seq_U87_Human0.99823096
76ARNT_22903824_ChIP-Seq_MCF-7_Human0.99273536
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99055545
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99055545
79TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98635465
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98394487
81CBX2_27304074_Chip-Seq_ESCs_Mouse0.98146747
82AHR_22903824_ChIP-Seq_MCF-7_Human0.98136314
83* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98100790
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96386823
85SMAD3_21741376_ChIP-Seq_ESCs_Human0.95624788
86SMAD3_21741376_ChIP-Seq_HESCs_Human0.95308898
87SMAD4_21741376_ChIP-Seq_HESCs_Human0.94904546
88CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94234982
89PIAS1_25552417_ChIP-Seq_VCAP_Human0.93981639
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93737328
91IGF1R_20145208_ChIP-Seq_DFB_Human0.92972816
92TET1_21490601_ChIP-Seq_MESCs_Mouse0.92073553
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91624457
94CTCF_27219007_Chip-Seq_Bcells_Human0.91335365
95TP53_16413492_ChIP-PET_HCT116_Human0.91201691
96* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90972860
97CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90112701
98DPY_21335234_ChIP-Seq_ESCs_Mouse0.90026060
99RNF2_27304074_Chip-Seq_NSC_Mouse0.87704905
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86976124
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86649974
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86532646
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86484222
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86331788
105BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85589512
106RUNX2_22187159_ChIP-Seq_PCA_Human0.85585611
107SOX9_26525672_Chip-Seq_HEART_Mouse0.85235663
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84807794
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84662435
110* PRDM14_20953172_ChIP-Seq_ESCs_Human0.84052483
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83786814
112RXR_22108803_ChIP-Seq_LS180_Human0.83431851
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82120053
114KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81800624
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79835222
116* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77528870
117OCT4_19829295_ChIP-Seq_ESCs_Human0.77016241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.24516011
2MP0003880_abnormal_central_pattern4.50991430
3* MP0003635_abnormal_synaptic_transmissio4.28982182
4MP0004270_analgesia4.00132066
5MP0009745_abnormal_behavioral_response3.44430104
6MP0002063_abnormal_learning/memory/cond3.43766661
7MP0002064_seizures3.15828440
8MP0002822_catalepsy3.15480632
9MP0005423_abnormal_somatic_nervous3.09005536
10MP0009046_muscle_twitch3.08447666
11MP0001968_abnormal_touch/_nociception2.97421763
12MP0002572_abnormal_emotion/affect_behav2.80499112
13MP0002734_abnormal_mechanical_nocicepti2.74191149
14MP0001486_abnormal_startle_reflex2.59702714
15MP0002272_abnormal_nervous_system2.57883773
16MP0002735_abnormal_chemical_nociception2.23137768
17MP0001501_abnormal_sleep_pattern2.22398242
18MP0002736_abnormal_nociception_after2.15614556
19MP0009780_abnormal_chondrocyte_physiolo2.15043201
20MP0002733_abnormal_thermal_nociception2.05427843
21MP0002909_abnormal_adrenal_gland2.05006550
22MP0008569_lethality_at_weaning2.02589147
23MP0001440_abnormal_grooming_behavior2.02425477
24MP0001970_abnormal_pain_threshold1.97556321
25MP0004858_abnormal_nervous_system1.93711693
26MP0002067_abnormal_sensory_capabilities1.89786203
27* MP0004811_abnormal_neuron_physiology1.87089546
28MP0002184_abnormal_innervation1.82220600
29MP0003329_amyloid_beta_deposits1.80628396
30MP0002557_abnormal_social/conspecific_i1.79526527
31MP0000778_abnormal_nervous_system1.77886711
32MP0003123_paternal_imprinting1.77697122
33MP0004924_abnormal_behavior1.70603620
34MP0005386_behavior/neurological_phenoty1.70603620
35MP0003879_abnormal_hair_cell1.70139983
36MP0000955_abnormal_spinal_cord1.65096136
37MP0004885_abnormal_endolymph1.52865555
38MP0005646_abnormal_pituitary_gland1.52616045
39MP0003787_abnormal_imprinting1.48559732
40* MP0002882_abnormal_neuron_morphology1.45301385
41* MP0002066_abnormal_motor_capabilities/c1.42289650
42MP0003633_abnormal_nervous_system1.40640951
43MP0001984_abnormal_olfaction1.36174474
44MP0005645_abnormal_hypothalamus_physiol1.34660021
45MP0000569_abnormal_digit_pigmentation1.32249238
46MP0006276_abnormal_autonomic_nervous1.30993348
47MP0008877_abnormal_DNA_methylation1.30731269
48MP0001502_abnormal_circadian_rhythm1.24668879
49MP0003631_nervous_system_phenotype1.16211963
50MP0003283_abnormal_digestive_organ1.15916557
51MP0002152_abnormal_brain_morphology1.13995699
52MP0004142_abnormal_muscle_tone1.07836388
53MP0008961_abnormal_basal_metabolism1.04234922
54MP0002229_neurodegeneration1.00237304
55MP0003075_altered_response_to0.99916413
56MP0003121_genomic_imprinting0.99863244
57MP0001905_abnormal_dopamine_level0.99523045
58MP0001529_abnormal_vocalization0.99414327
59MP0008872_abnormal_physiological_respon0.98055055
60MP0001188_hyperpigmentation0.95350965
61MP0001177_atelectasis0.94531192
62* MP0002069_abnormal_eating/drinking_beha0.94160546
63MP0005551_abnormal_eye_electrophysiolog0.93986158
64MP0004145_abnormal_muscle_electrophysio0.93669017
65MP0008874_decreased_physiological_sensi0.92196655
66MP0003122_maternal_imprinting0.90236628
67MP0000013_abnormal_adipose_tissue0.85544365
68MP0004085_abnormal_heartbeat0.82784634
69MP0003634_abnormal_glial_cell0.82263808
70MP0010386_abnormal_urinary_bladder0.82219191
71MP0003690_abnormal_glial_cell0.81683394
72MP0003632_abnormal_nervous_system0.81293573
73MP0000751_myopathy0.80224389
74MP0005535_abnormal_body_temperature0.78926645
75MP0004742_abnormal_vestibular_system0.78458680
76MP0000920_abnormal_myelination0.78173316
77MP0000631_abnormal_neuroendocrine_gland0.77236882
78MP0000604_amyloidosis0.77153548
79MP0005499_abnormal_olfactory_system0.77093227
80MP0005394_taste/olfaction_phenotype0.77093227
81MP0002090_abnormal_vision0.76077100
82MP0004147_increased_porphyrin_level0.75792644
83MP0003172_abnormal_lysosome_physiology0.75285400
84MP0001348_abnormal_lacrimal_gland0.74409533
85MP0002752_abnormal_somatic_nervous0.71754938
86MP0004510_myositis0.71527404
87MP0001963_abnormal_hearing_physiology0.70744935
88MP0005167_abnormal_blood-brain_barrier0.66312816
89MP0002638_abnormal_pupillary_reflex0.66056865
90MP0005409_darkened_coat_color0.64287240
91MP0004043_abnormal_pH_regulation0.61676755
92MP0004233_abnormal_muscle_weight0.61661846
93MP0003137_abnormal_impulse_conducting0.61482130
94MP0001485_abnormal_pinna_reflex0.59794765
95MP0003861_abnormal_nervous_system0.59618492
96MP0001346_abnormal_lacrimal_gland0.58905215
97MP0001299_abnormal_eye_distance/0.58472676
98MP0005623_abnormal_meninges_morphology0.56682960
99MP0004215_abnormal_myocardial_fiber0.56597757
100MP0005187_abnormal_penis_morphology0.56573057
101MP0001986_abnormal_taste_sensitivity0.55718250
102MP0001664_abnormal_digestion0.55589381
103* MP0010769_abnormal_survival0.55008406
104* MP0001943_abnormal_respiration0.53237856
105MP0000579_abnormal_nail_morphology0.52879965
106* MP0010770_preweaning_lethality0.51539287
107* MP0002082_postnatal_lethality0.51539287
108* MP0010768_mortality/aging0.51436794
109MP0003956_abnormal_body_size0.51352086
110MP0004484_altered_response_of0.51123902
111MP0004130_abnormal_muscle_cell0.47143483
112MP0003938_abnormal_ear_development0.46719524
113MP0001731_abnormal_postnatal_growth0.45582314
114MP0000026_abnormal_inner_ear0.45158729

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.40970389
2Focal motor seizures (HP:0011153)7.33595899
3Focal seizures (HP:0007359)5.76512063
4Visual hallucinations (HP:0002367)5.40097376
5Epileptic encephalopathy (HP:0200134)4.69731147
6Progressive cerebellar ataxia (HP:0002073)4.38335774
7Action tremor (HP:0002345)4.27404930
8Febrile seizures (HP:0002373)4.17661376
9Atonic seizures (HP:0010819)4.02624414
10Absence seizures (HP:0002121)3.89488498
11Supranuclear gaze palsy (HP:0000605)3.86595224
12Ankle clonus (HP:0011448)3.76767741
13Generalized tonic-clonic seizures (HP:0002069)3.76088213
14Poor eye contact (HP:0000817)3.64861593
15Broad-based gait (HP:0002136)3.62310932
16Papilledema (HP:0001085)3.58616204
17Dialeptic seizures (HP:0011146)3.56132180
18Gaze-evoked nystagmus (HP:0000640)3.49316392
19Impaired vibration sensation in the lower limbs (HP:0002166)3.45085548
20Depression (HP:0000716)3.41258231
21Mutism (HP:0002300)3.37166574
22Urinary bladder sphincter dysfunction (HP:0002839)3.30089807
23Abnormal social behavior (HP:0012433)3.26963149
24Impaired social interactions (HP:0000735)3.26963149
25Dysdiadochokinesis (HP:0002075)3.22212038
26Dysmetria (HP:0001310)3.12124782
27Abnormality of the lower motor neuron (HP:0002366)3.07867176
28Genetic anticipation (HP:0003743)3.07164211
29Postural instability (HP:0002172)3.06686809
30Anxiety (HP:0000739)3.05640558
31Impaired smooth pursuit (HP:0007772)2.98610217
32Truncal ataxia (HP:0002078)2.96854079
33Tetraplegia (HP:0002445)2.91155575
34Amblyopia (HP:0000646)2.87967917
35Torticollis (HP:0000473)2.83199867
36Abnormal eating behavior (HP:0100738)2.81120423
37Cerebral hypomyelination (HP:0006808)2.78803662
38Hemiparesis (HP:0001269)2.78368666
39Akinesia (HP:0002304)2.76723954
40Urinary urgency (HP:0000012)2.75987761
41Spastic gait (HP:0002064)2.73371352
42Abnormality of binocular vision (HP:0011514)2.71630890
43Diplopia (HP:0000651)2.71630890
44Intention tremor (HP:0002080)2.69249940
45Hemiplegia (HP:0002301)2.68706546
46Stereotypic behavior (HP:0000733)2.63618462
47Hyperventilation (HP:0002883)2.63036315
48Abnormality of ocular smooth pursuit (HP:0000617)2.60869204
49Focal dystonia (HP:0004373)2.60759805
50Scanning speech (HP:0002168)2.60551201
51Excessive salivation (HP:0003781)2.60493325
52Drooling (HP:0002307)2.60493325
53Neurofibrillary tangles (HP:0002185)2.55326024
54Megalencephaly (HP:0001355)2.54340035
55Bradykinesia (HP:0002067)2.52780283
56Ventricular fibrillation (HP:0001663)2.50926523
57Epileptiform EEG discharges (HP:0011182)2.50206691
58Sleep apnea (HP:0010535)2.50004632
59Cerebral inclusion bodies (HP:0100314)2.44560904
60EEG with generalized epileptiform discharges (HP:0011198)2.44481067
61Insomnia (HP:0100785)2.41628122
62Annular pancreas (HP:0001734)2.41283732
63Spastic tetraparesis (HP:0001285)2.36756581
64Dysmetric saccades (HP:0000641)2.36673669
65Hypsarrhythmia (HP:0002521)2.36029063
66Pointed chin (HP:0000307)2.35648269
67Impaired vibratory sensation (HP:0002495)2.34397025
68Progressive inability to walk (HP:0002505)2.33363044
69Abnormality of the corticospinal tract (HP:0002492)2.32375803
70Agitation (HP:0000713)2.31204688
71Craniofacial dystonia (HP:0012179)2.30812535
72Obstructive sleep apnea (HP:0002870)2.28482769
73Delusions (HP:0000746)2.27418156
74Termporal pattern (HP:0011008)2.23410280
75Insidious onset (HP:0003587)2.23410280
76Lower limb muscle weakness (HP:0007340)2.22911290
77Status epilepticus (HP:0002133)2.18517185
78Limb dystonia (HP:0002451)2.17257606
79Absent speech (HP:0001344)2.17197611
80Amyotrophic lateral sclerosis (HP:0007354)2.15494898
81Clonus (HP:0002169)2.11401838
82Fetal akinesia sequence (HP:0001989)2.08909801
83Inappropriate behavior (HP:0000719)2.06632301
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05590092
85Bundle branch block (HP:0011710)2.05544263
86Neuronal loss in central nervous system (HP:0002529)2.04307002
87Peripheral hypomyelination (HP:0007182)2.02605427
88Morphological abnormality of the pyramidal tract (HP:0002062)2.01855707
89Generalized myoclonic seizures (HP:0002123)1.99736712
90Bronchomalacia (HP:0002780)1.99651037
91Choreoathetosis (HP:0001266)1.99318125
92Apathy (HP:0000741)1.98861746
93Pheochromocytoma (HP:0002666)1.97222570
94Lower limb amyotrophy (HP:0007210)1.96839791
95Gait ataxia (HP:0002066)1.95682445
96Incomplete penetrance (HP:0003829)1.90363786
97Abnormal EKG (HP:0003115)1.89313485
98CNS hypomyelination (HP:0003429)1.88870544
99Increased circulating renin level (HP:0000848)1.88830964
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.88772313
101Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88772313
102Inability to walk (HP:0002540)1.85370680
103Abnormality of saccadic eye movements (HP:0000570)1.83931321
104Ankyloglossia (HP:0010296)1.83411628
105Polyphagia (HP:0002591)1.82988874
106Resting tremor (HP:0002322)1.80220418
107Lower limb asymmetry (HP:0100559)1.80046959
108Turricephaly (HP:0000262)1.79945421
109Rigidity (HP:0002063)1.79683529
110Blue irides (HP:0000635)1.78317455
111Spastic tetraplegia (HP:0002510)1.77446721
112Aqueductal stenosis (HP:0002410)1.76574026
113Rapidly progressive (HP:0003678)1.75474518
114Intellectual disability, profound (HP:0002187)1.73034880
115Diminished motivation (HP:0000745)1.72850907
116Psychosis (HP:0000709)1.70725278
117Paraplegia (HP:0010550)1.68042141
118Muscular hypotonia of the trunk (HP:0008936)1.63776668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.51840678
2NTRK34.51679781
3MAP3K94.11701677
4MARK13.63712444
5MAP3K42.86093009
6DAPK22.86003563
7MINK12.77784985
8PAK62.48428683
9PRKD32.47748138
10MAP2K72.29180555
11KSR22.20500150
12NTRK22.17052459
13CAMKK12.13525759
14NTRK11.98212360
15MAP2K41.69598311
16RIPK41.66744551
17CDK51.64111545
18DAPK11.63301706
19KSR11.57778519
20TNIK1.50947387
21SIK21.48619492
22STK381.47965044
23PRPF4B1.38785329
24MAP3K21.33227217
25FES1.30819510
26MAPK131.29006322
27TAOK11.26761380
28MAP3K121.25639747
29CAMK1D1.24000013
30UHMK11.23025862
31TYRO31.22524358
32GRK51.17993006
33PRKCG1.17420733
34CAMKK21.15670413
35PNCK1.13992578
36CDK191.12721636
37CASK1.09112683
38PLK21.09106191
39CAMK11.05707167
40PHKG21.04921541
41PHKG11.04921541
42ALK1.01433776
43STK111.01265659
44MAP3K130.98319600
45ARAF0.97993249
46RET0.96419038
47PRKCH0.94660156
48LATS20.93467546
49CDK150.90279093
50CDK180.89864036
51CAMK2A0.87789452
52FGFR20.86449861
53CDK140.85733297
54MARK20.85646045
55SGK4940.84295047
56SGK2230.84295047
57RIPK10.82215968
58RAF10.78958801
59CDK11A0.78557805
60PAK30.73104527
61PINK10.72855677
62DYRK1A0.72820840
63CSNK1G20.69831952
64SGK10.69693367
65CAMK2B0.68437511
66PDK10.68258398
67SGK20.68134543
68SGK30.67757244
69CDC42BPA0.65644809
70MAP3K10.64250665
71PKN10.62828144
72PDPK10.62000859
73SCYL20.60803804
74LMTK20.59849041
75CAMK1G0.57880624
76PTK2B0.57439338
77BRAF0.57238278
78BRSK10.54841669
79RPS6KA30.54167805
80PRKCZ0.53304894
81CAMK40.51761696
82MAPK120.50474044
83BMPR20.50276907
84FYN0.49888896
85MAP3K70.49384608
86TNK20.48349837
87DYRK20.47432217
88NEK60.47028648
89MAPK100.46805666
90NEK10.46143280
91DAPK30.45278733
92OXSR10.44248765
93CSNK1E0.43765005
94WNK10.40459249
95DMPK0.40093517
96RPS6KA20.39457841
97PRKCE0.38955792
98CSNK1D0.37668746
99CAMK2D0.37416145
100ROCK20.36227406
101FER0.36051860
102MAP2K10.34591267
103GSK3B0.33885200
104PRKCB0.33848767
105CSNK1G30.33416530
106MAP3K60.33058024
107PRKCA0.32897571
108CAMK2G0.32125660
109ERBB20.31665011
110CCNB10.31645427
111LIMK10.30798670
112PRKDC0.29999161
113ICK0.29491232
114WNK30.29479158
115MAP2K60.29094901
116PRKD20.28362367
117MAPK80.28340460
118CSNK1A10.27413621
119PRKG10.27147205

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.45900602
2* Synaptic vesicle cycle_Homo sapiens_hsa047213.06609057
3Olfactory transduction_Homo sapiens_hsa047402.79659662
4Circadian entrainment_Homo sapiens_hsa047132.78008441
5Long-term potentiation_Homo sapiens_hsa047202.69893220
6GABAergic synapse_Homo sapiens_hsa047272.65447963
7Glutamatergic synapse_Homo sapiens_hsa047242.64303730
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56993269
9Morphine addiction_Homo sapiens_hsa050322.48408267
10Amphetamine addiction_Homo sapiens_hsa050312.46181938
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29410429
12Dopaminergic synapse_Homo sapiens_hsa047282.19997873
13Salivary secretion_Homo sapiens_hsa049702.15845981
14Insulin secretion_Homo sapiens_hsa049112.14893121
15Cholinergic synapse_Homo sapiens_hsa047252.02781337
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.95795591
17Gastric acid secretion_Homo sapiens_hsa049711.90920410
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72714516
19Cocaine addiction_Homo sapiens_hsa050301.71438743
20Long-term depression_Homo sapiens_hsa047301.69995577
21Oxytocin signaling pathway_Homo sapiens_hsa049211.67682470
22Taste transduction_Homo sapiens_hsa047421.63219558
23Renin secretion_Homo sapiens_hsa049241.62277339
24Vitamin B6 metabolism_Homo sapiens_hsa007501.62227617
25Serotonergic synapse_Homo sapiens_hsa047261.56475137
26Calcium signaling pathway_Homo sapiens_hsa040201.55068459
27GnRH signaling pathway_Homo sapiens_hsa049121.51749343
28Type II diabetes mellitus_Homo sapiens_hsa049301.46464047
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45174485
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41475536
31Gap junction_Homo sapiens_hsa045401.36414007
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32055078
33cAMP signaling pathway_Homo sapiens_hsa040241.31422887
34Glioma_Homo sapiens_hsa052141.26962409
35Estrogen signaling pathway_Homo sapiens_hsa049151.23006173
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21122901
37Nitrogen metabolism_Homo sapiens_hsa009101.18095975
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16442157
39Axon guidance_Homo sapiens_hsa043601.13347398
40ErbB signaling pathway_Homo sapiens_hsa040121.11507924
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06749632
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04845835
43Melanogenesis_Homo sapiens_hsa049161.04099511
44Collecting duct acid secretion_Homo sapiens_hsa049660.96049566
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.94391388
46Pancreatic secretion_Homo sapiens_hsa049720.91427846
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.91172426
48Oocyte meiosis_Homo sapiens_hsa041140.89949608
49Dorso-ventral axis formation_Homo sapiens_hsa043200.89577069
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88623508
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86059643
52Phototransduction_Homo sapiens_hsa047440.84380845
53Thyroid hormone synthesis_Homo sapiens_hsa049180.80567459
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79781323
55Fatty acid biosynthesis_Homo sapiens_hsa000610.79259309
56Choline metabolism in cancer_Homo sapiens_hsa052310.78745129
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76754265
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.76290460
59Cardiac muscle contraction_Homo sapiens_hsa042600.75463863
60MAPK signaling pathway_Homo sapiens_hsa040100.73650159
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72487781
62VEGF signaling pathway_Homo sapiens_hsa043700.72200978
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70865970
64Dilated cardiomyopathy_Homo sapiens_hsa054140.70434378
65Vibrio cholerae infection_Homo sapiens_hsa051100.68332073
66mTOR signaling pathway_Homo sapiens_hsa041500.67836031
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64428125
68Ras signaling pathway_Homo sapiens_hsa040140.60933439
69Endometrial cancer_Homo sapiens_hsa052130.60861991
70Rap1 signaling pathway_Homo sapiens_hsa040150.60058947
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59707937
72Type I diabetes mellitus_Homo sapiens_hsa049400.58824160
73Alcoholism_Homo sapiens_hsa050340.58772662
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.58066600
75Glucagon signaling pathway_Homo sapiens_hsa049220.57465764
76Non-small cell lung cancer_Homo sapiens_hsa052230.56791877
77Endocytosis_Homo sapiens_hsa041440.55992369
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53892892
79Inositol phosphate metabolism_Homo sapiens_hsa005620.52245343
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51837506
81Bile secretion_Homo sapiens_hsa049760.50869353
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50089227
83Renal cell carcinoma_Homo sapiens_hsa052110.49565085
84Circadian rhythm_Homo sapiens_hsa047100.48893215
85Insulin signaling pathway_Homo sapiens_hsa049100.46753343
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46608510
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46136328
88Tight junction_Homo sapiens_hsa045300.45886598
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43985317
90Chemokine signaling pathway_Homo sapiens_hsa040620.43043918
91Wnt signaling pathway_Homo sapiens_hsa043100.42447020
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40798481
93Prion diseases_Homo sapiens_hsa050200.39787048
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37777646
95Hippo signaling pathway_Homo sapiens_hsa043900.35755083
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35258402
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35230389
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35141318
99Ovarian steroidogenesis_Homo sapiens_hsa049130.34573575
100Arginine and proline metabolism_Homo sapiens_hsa003300.34468995
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34041680
102Prolactin signaling pathway_Homo sapiens_hsa049170.32786684
103Colorectal cancer_Homo sapiens_hsa052100.32547866
104Arginine biosynthesis_Homo sapiens_hsa002200.32382135
105AMPK signaling pathway_Homo sapiens_hsa041520.31458151
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.29530606
107African trypanosomiasis_Homo sapiens_hsa051430.28344597
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28082716
109Alzheimers disease_Homo sapiens_hsa050100.27621946
110Platelet activation_Homo sapiens_hsa046110.27100620
111beta-Alanine metabolism_Homo sapiens_hsa004100.25734678
112Butanoate metabolism_Homo sapiens_hsa006500.25473631
113Mineral absorption_Homo sapiens_hsa049780.24517838
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.24058829
115Regulation of autophagy_Homo sapiens_hsa041400.15481495

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »